MCID: BLR031
MIFTS: 36

Biliary Tract Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Biliary Tract Benign Neoplasm

MalaCards integrated aliases for Biliary Tract Benign Neoplasm:

Name: Biliary Tract Benign Neoplasm 12 15
Neoplasm of Extrahepatic Bile Ducts 12
Tumor of the Extrahepatic Bile Duct 12
Extrahepatic Bile Duct Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050625
NCIt 51 C4441
UMLS 74 C0345913

Summaries for Biliary Tract Benign Neoplasm

Disease Ontology : 12 A hepatobiliary benign neoplasm located in the biliary tract.

MalaCards based summary : Biliary Tract Benign Neoplasm, also known as neoplasm of extrahepatic bile ducts, is related to gallbladder adenoma and bile duct adenoma. An important gene associated with Biliary Tract Benign Neoplasm is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Human cytomegalovirus infection and Endometrial cancer. Affiliated tissues include the biliary tract, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Biliary Tract Benign Neoplasm

Diseases related to Biliary Tract Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 266)
# Related Disease Score Top Affiliating Genes
1 gallbladder adenoma 31.8 CDKN2A HRAS
2 bile duct adenoma 31.8 CDKN2A KRT7 MUC1
3 biliary papillomatosis 30.3 HRAS KRAS KRT7 MUC1 MUC6 TP53
4 cholangiocarcinoma 29.8 CDKN2A KRAS KRT7 MUC1 TP53
5 gallbladder lipoma 11.3
6 extrahepatic bile duct lipoma 11.3
7 bile duct cystadenoma 11.3
8 adenocarcinoma of the gallbladder and extrahepatic biliary tract 10.5
9 squamous cell carcinoma of gallbladder and extrahepatic biliary tract 10.5
10 neuroendocrine tumor 10.4
11 ovarian mucinous neoplasm 10.3 KRT7 MUC6
12 eccrine sweat gland neoplasm 10.3 KRT7 TP53
13 acinar cell carcinoma 10.3 KRT7 TP53
14 germ cell and embryonal cancer 10.3 KRT7 TP53
15 pleomorphic carcinoma 10.3 KRT7 TP53
16 colorectal cancer 1 10.3 MUC1 MUC6
17 granulosa cell tumor of the ovary 10.3 KRT7 TP53
18 hidradenocarcinoma 10.3 KRT7 TP53
19 mixed ductal-endocrine carcinoma 10.3 MUC1 MUC6
20 ethmoid sinusitis 10.3 MUC1 MUC6
21 papilloma of choroid plexus 10.3 MUC1 TP53
22 epstein-barr virus-associated gastric carcinoma 10.3 CDKN2A MUC6
23 suppressor of tumorigenicity 3 10.3 CDKN2A TP53
24 rhabdoid tumor predisposition syndrome 1 10.3 MUC1 TP53
25 pre-malignant neoplasm 10.3 CDKN2A TP53
26 tongue disease 10.3 CDKN2A TP53
27 anogenital venereal wart 10.3 CDKN2A TP53
28 penile cancer 10.3 CDKN2A TP53
29 megaesophagus 10.3 CDKN2A TP53
30 squamous cell papilloma 10.3 CDKN2A TP53
31 penile disease 10.3 CDKN2A TP53
32 supratentorial cancer 10.3 CDKN2A TP53
33 cervix disease 10.3 CDKN2A TP53
34 cervix carcinoma 10.3 CDKN2A TP53
35 cellular schwannoma 10.3 CDKN2A TP53
36 central nervous system lymphoma 10.3 CDKN2A TP53
37 optic nerve neoplasm 10.3 CDKN2A TP53
38 carcinoid syndrome 10.3
39 cerebrum cancer 10.3 CDKN2A TP53
40 verrucous carcinoma 10.2 CDKN2A TP53
41 sarcomatoid renal cell carcinoma 10.2 MUC1 TP53
42 retinal cancer 10.2 CDKN2A TP53
43 optic nerve glioma 10.2 MUC1 TP53
44 anal squamous cell carcinoma 10.2 CDKN2A TP53
45 gastric adenosquamous carcinoma 10.2 CDKN2A TP53
46 esophageal disease 10.2 CDKN2A TP53
47 cerebral primitive neuroectodermal tumor 10.2 MUC1 TP53
48 cervix small cell carcinoma 10.2 CDKN2A TP53
49 juvenile pilocytic astrocytoma 10.2 CDKN2A TP53
50 laryngeal disease 10.2 CDKN2A TP53

Graphical network of the top 20 diseases related to Biliary Tract Benign Neoplasm:



Diseases related to Biliary Tract Benign Neoplasm

Symptoms & Phenotypes for Biliary Tract Benign Neoplasm

GenomeRNAi Phenotypes related to Biliary Tract Benign Neoplasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 HRAS KRAS MUC1
2 Decreased viability GR00106-A-0 9.47 KRAS
3 Decreased viability GR00221-A-1 9.47 HRAS KRAS
4 Decreased viability GR00221-A-2 9.47 HRAS KRAS
5 Decreased viability GR00221-A-3 9.47 HRAS
6 Decreased viability GR00301-A 9.47 KRAS
7 Decreased viability GR00381-A-1 9.47 KRAS
8 Decreased viability GR00402-S-2 9.47 HRAS KRAS MUC1

MGI Mouse Phenotypes related to Biliary Tract Benign Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 CDKN2A HRAS KRAS TP53

Drugs & Therapeutics for Biliary Tract Benign Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Winged Perimeter Versus Traditional Plastic Biliary Stent for Malignant Bile Duct Obstruction Completed NCT01514214 Not Applicable
2 Process Optimization of Preoperative Biliary Drainage in Patients With Malignant Obstructive Jaundice Not yet recruiting NCT03527875 Not Applicable

Search NIH Clinical Center for Biliary Tract Benign Neoplasm

Genetic Tests for Biliary Tract Benign Neoplasm

Anatomical Context for Biliary Tract Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Biliary Tract Benign Neoplasm:

20
The Biliary Tract

Publications for Biliary Tract Benign Neoplasm

Articles related to Biliary Tract Benign Neoplasm:

# Title Authors Year
1
Neuroendocrine tumor of the extrahepatic bile duct: A case report. ( 28915429 )
2017
2
Primary non-functioning neuroendocrine tumor of the extrahepatic bile duct. ( 27128160 )
2016
3
Carcinoid tumor of the extrahepatic bile duct in an adolescent: prolonged disease-free survival after surgical resection. ( 23768505 )
2014
4
Neuroendocrine tumor of the extrahepatic bile duct: a tumor in an unusual site visualized by cholangioscopy. ( 24150737 )
2013
5
Carcinoid tumor of the extrahepatic bile duct: report of a case. ( 26181459 )
2013
6
Non-functioning well-differentiated neuroendocrine tumor of the extrahepatic bile duct: an unusual suspect? ( 17897922 )
2007

Variations for Biliary Tract Benign Neoplasm

Expression for Biliary Tract Benign Neoplasm

Search GEO for disease gene expression data for Biliary Tract Benign Neoplasm.

Pathways for Biliary Tract Benign Neoplasm

Pathways related to Biliary Tract Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 CDKN2A HRAS KRAS TP53
2
Show member pathways
12.66 CDKN2A HRAS KRAS TP53
3 12.61 CDKN2A HRAS KRAS TP53
4
Show member pathways
12.57 CDKN2A HRAS KRAS TP53
5
Show member pathways
12.52 CDKN2A HRAS KRAS TP53
6
Show member pathways
12.45 CDKN2A HRAS KRAS TP53
7
Show member pathways
12.42 HRAS KRAS TP53
8
Show member pathways
12.41 HRAS KRAS TP53
9
Show member pathways
12.33 HRAS KRAS TP53
10
Show member pathways
12.28 HRAS KRAS TP53
11 12.25 CDKN2A HRAS KRAS TP53
12 12.13 HRAS KRAS TP53
13
Show member pathways
12.12 HRAS KRAS MUC1 MUC6
14
Show member pathways
12.09 HRAS KRAS TP53
15
Show member pathways
12.05 HRAS KRAS TP53
16 12.01 CDKN2A HRAS KRAS TP53
17
Show member pathways
12 HRAS KRAS TP53
18
Show member pathways
11.96 HRAS KRAS TP53
19 11.95 HRAS KRAS TP53
20
Show member pathways
11.95 HRAS KRAS TP53
21 11.93 CDKN2A HRAS KRAS TP53
22
Show member pathways
11.86 HRAS KRAS TP53
23 11.79 HRAS KRAS TP53
24 11.76 HRAS KRAS TP53
25 11.76 CDKN2A HRAS KRAS TP53
26 11.71 CDKN2A HRAS TP53
27 11.52 CDKN2A HRAS KRAS TP53
28 11.45 HRAS KRAS TP53
29 11.42 HRAS KRAS TP53
30 11.41 HRAS KRAS TP53
31 11.38 HRAS KRAS
32 11.34 HRAS TP53
33 11.33 HRAS KRAS
34 11.3 CDKN2A HRAS KRAS TP53
35 11.22 HRAS KRAS
36 11.18 CDKN2A TP53
37 11.15 HRAS KRAS
38 11.15 HRAS KRAS
39
Show member pathways
11.13 HRAS KRAS
40 11.09 HRAS KRAS TP53
41
Show member pathways
11.08 HRAS KRAS
42 11.02 HRAS KRAS
43 10.99 HRAS KRAS
44 10.98 CDKN2A TP53
45
Show member pathways
10.98 CDKN2A TP53
46 10.93 HRAS KRAS
47 10.79 CDKN2A HRAS KRAS TP53
48 10.69 HRAS KRAS

GO Terms for Biliary Tract Benign Neoplasm

Biological processes related to Biliary Tract Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.71 KRAS MUC1 TP53
2 cell cycle arrest GO:0007050 9.58 CDKN2A HRAS TP53
3 positive regulation of gene expression GO:0010628 9.56 CDKN2A HRAS KRAS TP53
4 intrinsic apoptotic signaling pathway GO:0097193 9.52 HRAS TP53
5 cell aging GO:0007569 9.51 HRAS TP53
6 cellular response to gamma radiation GO:0071480 9.49 HRAS TP53
7 cellular senescence GO:0090398 9.48 CDKN2A HRAS
8 regulation of long-term neuronal synaptic plasticity GO:0048169 9.46 HRAS KRAS
9 positive regulation of cellular senescence GO:2000774 9.43 CDKN2A KRAS
10 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.37 MUC1 TP53
11 replicative senescence GO:0090399 9.32 CDKN2A TP53
12 Ras protein signal transduction GO:0007265 9.26 CDKN2A HRAS KRAS TP53
13 response to isolation stress GO:0035900 9.16 HRAS KRAS
14 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.92 HRAS KRAS MUC1 MUC6

Molecular functions related to Biliary Tract Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53

Sources for Biliary Tract Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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