MCID: BLR031
MIFTS: 30

Biliary Tract Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Biliary Tract Benign Neoplasm

MalaCards integrated aliases for Biliary Tract Benign Neoplasm:

Name: Biliary Tract Benign Neoplasm 12 15
Neoplasm of Extrahepatic Bile Ducts 12
Tumor of the Extrahepatic Bile Duct 12
Extrahepatic Bile Duct Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050625
NCIt 50 C4441
SNOMED-CT 67 126855001
UMLS 70 C0345913

Summaries for Biliary Tract Benign Neoplasm

Disease Ontology : 12 A hepatobiliary benign neoplasm located in the biliary tract.

MalaCards based summary : Biliary Tract Benign Neoplasm, also known as neoplasm of extrahepatic bile ducts, is related to gallbladder benign neoplasm and bile duct adenoma. An important gene associated with Biliary Tract Benign Neoplasm is KRT7 (Keratin 7), and among its related pathways/superpathways are VEGF Signaling and Diseases of glycosylation. Affiliated tissues include biliary tract and breast, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Biliary Tract Benign Neoplasm

Diseases related to Biliary Tract Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 507)
# Related Disease Score Top Affiliating Genes
1 gallbladder benign neoplasm 31.9 KRT7 KRAS HRAS
2 bile duct adenoma 31.6 TP53 NCAM1 MUC1 KRT7 KRT19
3 ampulla of vater benign neoplasm 31.5 SYP KRAS HRAS
4 biliary papillomatosis 31.3 MUC6 MUC5AC MUC1 KRT7 FAM47A CEACAM5
5 neuroendocrine tumor 30.1 SYP NCAM1 KRT19 HRAS
6 intrahepatic cholangiocarcinoma 29.5 TP53 MUC5AC MUC1 KRT7 KRT19 KRAS
7 cholangiocarcinoma 28.8 TP53 NCAM1 MUC5AC MUC1 KRT7 KRT19
8 extrahepatic bile duct lipoma 11.2
9 bile duct cystadenoma 11.2
10 proliferating trichilemmal cyst 10.4 KRT7 KRT19
11 anal gland adenocarcinoma 10.4 MUC5AC KRT7
12 anus adenocarcinoma 10.4 MUC5AC KRT7
13 intrahepatic gall duct cancer 10.4 KRT7 KRT19
14 apocrine adenocarcinoma 10.4 MUC1 KRT7
15 cervical mucinous adenocarcinoma 10.4 MUC6 KRT7
16 squamous cell bile duct carcinoma 10.4 KRT7 KRT19
17 pulmonary artery leiomyosarcoma 10.4 KRT7 KRT19
18 scrotum paget's disease 10.4 MUC1 KRT7
19 gallbladder signet ring cell adenocarcinoma 10.4 MUC1 KRT7
20 ovarian seromucinous carcinoma 10.4 TP53 KRT7
21 breast hemangioma 10.4 TP53 KRT7
22 necrotizing sialometaplasia 10.3 TP53 KRT7
23 leukoplakia of penis 10.3 KRT7 CEACAM5
24 papillary transitional carcinoma 10.3 TP53 KRT7
25 urethral villous adenoma 10.3 KRT7 CEACAM5
26 large cell acanthoma 10.3 TP53 KRT7
27 colloid carcinoma of the pancreas 10.3 MUC5AC MUC1
28 ureter adenocarcinoma 10.3 KRT7 CEACAM5
29 gastric tubular adenocarcinoma 10.3 MUC6 MUC5AC
30 malignant acrospiroma 10.3 KRT7 CEACAM5
31 anal paget's disease 10.3 KRT7 CEACAM5
32 cutaneous mucoepidermoid carcinoma 10.3 KRT7 CEACAM5
33 external ear carcinoma 10.3 KRT7 CEACAM5
34 vulva adenocarcinoma 10.3 KRT7 CEACAM5
35 vulval paget's disease 10.3 KRT7 CEACAM5
36 female urethral cancer 10.3 KRT7 CEACAM5
37 eccrine adenocarcinoma 10.3 KRT7 CEACAM5
38 adenoid squamous cell carcinoma 10.3 KRT7 KRT19
39 mucinous ovarian cystadenoma 10.3 KRT7 CEACAM5
40 uterus leiomyosarcoma 10.3 KRT7 KRT19
41 carcinoid syndrome 10.3
42 conjunctival degeneration 10.3 TP53 MUC5AC
43 adenoid basal cell carcinoma 10.3 KRT7 CEACAM5
44 basosquamous carcinoma 10.3 TP53 MUC6
45 parachordoma 10.3 MUC1 KRT7
46 malignant syringoma 10.3 KRT7 CEACAM5
47 bladder clear cell adenocarcinoma 10.3 TP53 KRT7
48 mucoepidermoid esophageal carcinoma 10.3 TP53 CEACAM5
49 uterine corpus sarcoma 10.3 KRT7 KRT19
50 gastric diffuse adenocarcinoma 10.3 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Biliary Tract Benign Neoplasm:



Diseases related to Biliary Tract Benign Neoplasm

Symptoms & Phenotypes for Biliary Tract Benign Neoplasm

GenomeRNAi Phenotypes related to Biliary Tract Benign Neoplasm according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.89 HRAS KRAS MUC1 NCAM1
2 Decreased viability GR00055-A-2 9.89 HRAS KRAS MUC1
3 Decreased viability GR00055-A-3 9.89 KRAS
4 Decreased viability GR00106-A-0 9.89 KRAS
5 Decreased viability GR00221-A-1 9.89 HRAS KRAS
6 Decreased viability GR00221-A-2 9.89 HRAS KRAS
7 Decreased viability GR00221-A-3 9.89 HRAS
8 Decreased viability GR00249-S 9.89 MUC1
9 Decreased viability GR00301-A 9.89 KRAS
10 Decreased viability GR00381-A-1 9.89 KRAS
11 Reduced mammosphere formation GR00396-S 9.1 AFP HRAS KRAS KRT7 MUC5AC NCAM1

Drugs & Therapeutics for Biliary Tract Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Biliary Tract Benign Neoplasm

Genetic Tests for Biliary Tract Benign Neoplasm

Anatomical Context for Biliary Tract Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Biliary Tract Benign Neoplasm:

19
Biliary Tract

MalaCards organs/tissues related to Biliary Tract Benign Neoplasm:

40
Breast

Publications for Biliary Tract Benign Neoplasm

Articles related to Biliary Tract Benign Neoplasm:

# Title Authors PMID Year
1
Application of multiple Roux-en-Y hepaticojejunostomy reconstruction by formation of bile hilar duct lake in the operation of hilar cholangiocarcinoma. 61
31970171 2020
2
Primary non-functioning neuroendocrine tumor of the extrahepatic bile duct. 61
27128160 2017
3
Neuroendocrine tumor of the extrahepatic bile duct: A case report. 61
28915429 2017
4
Metastatic breast cancer mimicking a hilar cholangiocarcinoma: case report and review of the literature. 61
25515643 2014
5
Carcinoid tumor of the extrahepatic bile duct in an adolescent: prolonged disease-free survival after surgical resection. 61
23768505 2014
6
Preoperative biliary drainage in hilar cholangiocarcinoma: When and how? 61
24634710 2014
7
Carcinoid tumor of the extrahepatic bile duct: report of a case. 61
26181459 2013
8
Neuroendocrine tumor of the extrahepatic bile duct: a tumor in an unusual site visualized by cholangioscopy. 61
24150737 2013
9
Non-functioning well-differentiated neuroendocrine tumor of the extrahepatic bile duct: an unusual suspect? 61
17897922 2007
10
[BENIGN TUMOR OF THE EXTRAHEPATIC BILE DUCT]. 61
14325010 1965

Variations for Biliary Tract Benign Neoplasm

Expression for Biliary Tract Benign Neoplasm

Search GEO for disease gene expression data for Biliary Tract Benign Neoplasm.

Pathways for Biliary Tract Benign Neoplasm

Pathways related to Biliary Tract Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.13 TP53 MUC1 KRAS HRAS
2
Show member pathways
11.9 MUC6 MUC5AC MUC1
3 11.84 NCAM1 KRT19 AFP
4 11.79 NCAM1 MUC1 CEACAM5
5 11.77 TP53 KRAS HRAS
6 11.75 TP53 KRAS HRAS
7 11.71 TP53 KRAS HRAS
8 11.68 TP53 KRAS HRAS
9
Show member pathways
11.65 MUC6 MUC5AC MUC1
10
Show member pathways
11.43 MUC6 MUC5AC MUC1 KRAS HRAS
11 11.36 TP53 KRAS HRAS
12 11.28 TP53 KRAS HRAS
13 11.16 TP53 KRAS HRAS
14 10.85 KRAS HRAS
15 10.72 NCAM1 MUC1 CEACAM5
16 10.52 KRAS HRAS

GO Terms for Biliary Tract Benign Neoplasm

Cellular components related to Biliary Tract Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC6 MUC5AC MUC1

Biological processes related to Biliary Tract Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.5 TP53 KRAS HRAS
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.4 TP53 MUC1
3 response to isolation stress GO:0035900 9.37 KRAS HRAS
4 O-glycan processing GO:0016266 9.33 MUC6 MUC5AC MUC1
5 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.26 TP53 MUC1
6 regulation of long-term neuronal synaptic plasticity GO:0048169 9.13 SYP KRAS HRAS
7 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.02 MUC6 MUC5AC MUC1 KRAS HRAS

Sources for Biliary Tract Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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