Biliary Tract Disease

Categories: Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Biliary Tract Disease

MalaCards integrated aliases for Biliary Tract Disease:

Name: Biliary Tract Disease 12 15 17
Biliary Tract Diseases 44 70
Anomaly of the Biliary Tract 6
Biliary Tract Abnormality 29


External Ids:

Disease Ontology 12 DOID:9741
ICD9CM 34 576.9
MeSH 44 D001660
SNOMED-CT 67 5235004
ICD10 32 K83.8 K83.9
UMLS 70 C0005424

Summaries for Biliary Tract Disease

MalaCards based summary : Biliary Tract Disease, also known as biliary tract diseases, is related to cholangitis and cholelithiasis, and has symptoms including digestive system symptom An important gene associated with Biliary Tract Disease is C12orf60 (Chromosome 12 Open Reading Frame 60), and among its related pathways/superpathways are MicroRNAs in cancer and Nuclear Receptor transcription pathway. The drugs Propofol and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and small intestine.

Related Diseases for Biliary Tract Disease

Diseases in the Biliary Tract Disease family:

Rare Biliary Tract Disease

Diseases related to Biliary Tract Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 278)
# Related Disease Score Top Affiliating Genes
1 cholangitis 31.8 NR1I2 NR1H4 MIR222 GPT ABCB4 ABCB11
2 cholelithiasis 31.7 NR1H4 GPT ABCB4
3 sclerosing cholangitis 31.5 NR1I2 NR1H4 MIR222 GPT ABCB4 ABCB11
4 cholestasis 31.4 NR1I3 NR1I2 NR1H4 NR1H2 GPT ABCC4
5 cholangitis, primary sclerosing 31.4 NR1I2 NR1H4 MIR222 MIR199A1 GPT CCR6
6 primary biliary cholangitis 31.3 NR1I3 NR1I2 NR1H4 MIR483 MIR17 MIR150
7 biliary atresia 31.3 NR1H4 GPT ABCB4 ABCB11
8 gallbladder disease 31.1 SERPINA3 NR1H4 MIR483 MIR199A1 MIR196A1 MIR17
9 extrahepatic cholestasis 31.0 NR1H4 GPT ABCB4 ABCB11
10 bile duct disease 31.0 SERPINA3 NR1I2 NR1H4 MIR483 MIR29A MIR222
11 bile duct cysts 30.9 GPT ABCB4 ABCB11
12 gastrointestinal system disease 30.9 SERPINA3 MIR483 MIR29A MIR222 MIR199A1 MIR196A1
13 bile duct cancer 30.9 MIR199A1 MIR17 MIR145 GPT
14 suppurative cholangitis 30.8 GPT ABCB4
15 bladder disease 30.7 MIR199A1 MIR196A1 MIR17 MIR150 MIR145 CCR6
16 bilirubin metabolic disorder 30.7 NR1I3 NR1I2 NR1H4 GPT ABCC4 ABCB4
17 liver disease 30.7 SERPINA3 NR1I2 NR1H4 GPT ABCB4 ABCB11
18 disease by infectious agent 30.7 SERPINA3 MIR199A1 MIR196A1 MIR17 MIR150 GPT
19 non-alcoholic fatty liver disease 30.7 NR1H4 MIR199A1 MIR17 GPT ABCB11
20 pancreas disease 30.7 SERPINA3 MIR483 MIR199A1 MIR196A1 MIR17 MIR150
21 acute cystitis 30.7 SERPINA3 GPT CCR6
22 cholecystolithiasis 30.5 GPT ABCB4
23 alcohol use disorder 30.4 MIR199A1 GPT CCR6
24 genetic biliary tract disease 11.2
25 rare biliary tract disease 11.2
26 bile acid synthesis defect, congenital, 2 10.6 NR1I3 NR1I2 NR1H4 ABCB11
27 cholestasis, progressive familial intrahepatic, 5 10.6 NR1I3 NR1H4 ABCB4 ABCB11
28 cholestasis, intrahepatic, of pregnancy, 1 10.6 NR1I3 NR1I2 NR1H4 ABCB4 ABCB11
29 cholecystitis 10.6
30 cholestasis, progressive familial intrahepatic, 3 10.6 NR1H4 ABCC4 ABCB4 ABCB11
31 cholestasis, progressive familial intrahepatic, 2 10.6 NR1H4 ABCC4 ABCB4 ABCB11
32 hepatic vascular disease 10.6 NR1H4 MIR199A1 GPT CCR6 ABCB4
33 familial intrahepatic cholestasis 10.6 NR1H4 ABCB4 ABCB11
34 intrahepatic cholestasis of pregnancy 10.6 NR1I3 NR1I2 NR1H4 GPT ABCB4 ABCB11
35 cholestasis, benign recurrent intrahepatic, 1 10.6 NR1I2 NR1H4 ABCC4 ABCB4 ABCB11
36 progressive familial intrahepatic cholestasis 10.6 NR1H4 ABCC4 ABCB4 ABCB11
37 cholestasis, progressive familial intrahepatic, 4 10.6 NR1H4 ABCB4 ABCB11
38 cholestasis, benign recurrent intrahepatic, 2 10.6 NR1H4 ABCB4 ABCB11
39 common bile duct disease 10.6 MIR222 GPT ABCB4 ABCB11
40 lipid storage disease 10.6 SERPINA3 NR1H4 MIR199A1 GPT CCR6
41 autoimmune disease of gastrointestinal tract 10.6 SERPINA3 NR1H4 MIR199A1 MIR196A1 MIR150 GPT
42 intestinal benign neoplasm 10.6 SERPINA3 MIR199A1 MIR196A1 MIR17 MIR145 CCR6
43 acute porphyria 10.6 NR1I3 NR1I2 NR1H2
44 bone resorption disease 10.6 SERPINA3 MIR222 MIR199A1 MIR196A1 CCR6
45 lymph node disease 10.6 SERPINA3 MIR483 MIR145 CCR6
46 cerebrotendinous xanthomatosis 10.6 NR1I2 NR1H4 NR1H2
47 coronavirus infectious disease 10.6 SERPINA3 MIR17 GPT CCR6
48 atp8b1 deficiency 10.6 NR1H4 ABCB11
49 leukocyte disease 10.6 SERPINA3 MIR199A1 MIR196A1 MIR17 GPT CCR6
50 lysosomal storage disease 10.6 SERPINA3 NR1H4 MIR199A1 GPT CCR6

Comorbidity relations with Biliary Tract Disease via Phenotypic Disease Network (PDN):

Acute Cystitis Acute Pancreatitis

Graphical network of the top 20 diseases related to Biliary Tract Disease:

Diseases related to Biliary Tract Disease

Symptoms & Phenotypes for Biliary Tract Disease

UMLS symptoms related to Biliary Tract Disease:

digestive system symptom

Drugs & Therapeutics for Biliary Tract Disease

Drugs for Biliary Tract Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Acetaminophen Approved Phase 4 103-90-2 1983
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
Remifentanil Approved Phase 4 132875-61-7 60815
6 Anesthetics Phase 4
7 Hypnotics and Sedatives Phase 4
8 Anesthetics, General Phase 4
9 Anesthetics, Intravenous Phase 4
10 Narcotics Phase 4
11 Analgesics Phase 4
12 Analgesics, Opioid Phase 4
13 Liver Extracts Phase 3
14 Pharmaceutical Solutions Phase 3
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
Gemcitabine Approved Phase 2 95058-81-4 60750
Fluorouracil Approved Phase 2 51-21-8 3385
leucovorin Approved Phase 2 58-05-9 6006
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
20 Vasodilator Agents Phase 2
21 Vitamin B9 Phase 2
22 Nutrients Phase 2
23 Trace Elements Phase 2
24 Micronutrients Phase 2
25 Anti-Infective Agents Phase 2
26 Vitamin B Complex Phase 2
27 Vitamins Phase 2
28 Immunosuppressive Agents Phase 2
29 Folate Phase 2
30 Immunologic Factors Phase 2
31 Antiviral Agents Phase 2
32 Antidotes Phase 2
33 Antimetabolites Phase 2
34 Protective Agents Phase 2
Midazolam Approved, Illicit 59467-70-8 4192
Succinylcholine Approved 306-40-1 5314
37 Neurotransmitter Agents
38 Psychotropic Drugs
39 GABA Modulators
40 Anti-Anxiety Agents
41 Ulipristal acetate 126784-99-4

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 A Clinical Registry to Assess Performance and Clinical Utility of the SpyGlass Direct Visualization System Completed NCT00751998 Phase 4
2 Alfentanil vs Remifentanil in Patient-controlled Sedation During ERCP.A Randomized Double-blind Study Completed NCT01350037 Phase 4 alfentanil;remifentanil
3 An Expertise-based Randomized Controlled Trial Comparing Minilaparotomy Cholecystectomy and Laparoscopic Cholecystectomy Completed NCT00370344 Phase 2, Phase 3
4 A Multicenter Randomized Controlled Trial to Compare the Efficacy of End-ischemic Dual Hypothermic Oxygenated Perfusion With Standard Static Cold Storage of Liver Grafts Donated After Circulatory Death in Preventing Biliary Complications Completed NCT02584283 Phase 3 Glutathione
5 Treatment of Suspected Cholelithiasis With Nitroglycerin: a Randomized, Prospective Double-blind Trial Unknown status NCT01715220 Phase 2 sublingual nitroglycerine
6 Prospective Phase II Randomized Trial-Weekly Gemcitabine Plus High-Dose 5-Fluorouracil/ Leucovorin in the Treatment of Advanced or Metastatic Carcinoma of the Biliary Tract Completed NCT00201305 Phase 2 Gemcitabine+5FU+Leucovorin
7 Effect of a Fatty Meal on Cannulation at Endoscopic Retrograde Cholangiopancreatography Completed NCT00124202 Phase 1, Phase 2
8 A Phase 2 Open Label, Proof of Concept Study of HTD1801 (BUDCA) in Adult Subjects With Primary Biliary Cholangitis (PBC) and an Inadequate Response to Standard Therapy - PRONTO-PBC Recruiting NCT04604652 Phase 2 HTD1801 (BUDCA)
9 Safety and Efficacy Study of IL-10 (Tenovil TM) in the Prevention of Post-ERCP Acute Pancreatitis (Study P02580)(TERMINATED) Terminated NCT00040131 Phase 2 IL-10
10 A Phase 2, Randomized, Double-Blind Study of HTD1801 vs Ursodeoxycholic Acid (UDCA) in Adolescents With Primary Sclerosing Cholangitis (PSC) Withdrawn NCT03678480 Phase 2 HTD1801;Ursodeoxycholic Acid
11 An Evaluation of the Utility of the ExSpiron Respiratory Variation Monitor During Upper GI Endoscopy Unknown status NCT02310230
12 Comparison Between Continuous Infusion and Intermittent Bolus Injection of Propofol for Deep Sedation During Endoscopic Retrograde Cholangiopancreatography: a Prospective Randomized Controlled Study Unknown status NCT01900938 Midazolam;Propofol
13 Zhujiang Hospital of the Southern Medical University Unknown status NCT03074708
14 Assessment of Cholangio-pancreatoscopy for the Diagnosis and the Treatment of Biliary and Pancreatic Diseases Trial " EASYSPY " Unknown status NCT03190343
15 Clinical Registry of Cholangioscopy Using the SpyGlass™ Direct Visualization System Throughout China Completed NCT02287194
16 A Network on the Quality of ERCP, on the Organization of the Endoscopic Units and on the Training of the Endoscopists in Italy Completed NCT02971579
17 Endoscopic Treatment of Benign Biliary Strictures and Cystic Duct Leakages With a Novel Biodegradable Polydioxanone Biliary Stent Completed NCT02353286
18 A Multicenter Randomized Trial Comparing the Use of Touch and no Touch Guide-wire Techniques for Deep Biliary Cannulation: the TNT Study Completed NCT01954602
19 Prospective Evaluation of the Clinical Utility of Endoscopic Retrograde Cholangiopancreatography (ERCP) Guided Cholangiopancreatoscopy With the SpyGlass DS. Completed NCT02524418
20 Is Needle Knife Fistulotomy An Effective First Step Strategy For All ERCPs? Completed NCT03698266
21 Sahlgrenska EUS ERCP Study Completed NCT03504293
22 Endoscopic Ultrasound Guided Rendezvous or Direct Interventions Versus Advanced ERCP Techniques for Biliary Access and Therapy Completed NCT01678326
23 Biodegradable Stent Implantation in Biliary Benign Strictures. Spanish Register. Completed NCT04115696
24 Comparison of Standard Endotracheal Intubation [SEI] and Endoscope Assisted Endotracheal Intubation [EAE] Recruiting NCT03879720
25 A Prospective Study: Magnetic Compression Anastomosis for Recanalization of Biliary Stricture Recruiting NCT04170933
26 Fistulotomy as the Primary Cannulation Technique for All Patients Undergoing ERCP: A Randomized, Controlled Trial Recruiting NCT04559867
27 Prospective Evaluation of Biliary Tissue Sampling With ERCP Recruiting NCT04572711
28 Analysis of Biliary Microbiota in Hepatobiliopancreatic Diseases Compared to Healthy People [MICROBILIO] Not yet recruiting NCT04391426
29 Endo-biliary Laser Excision of Biliary Stenoses: Initial Experience and Feasibility Withdrawn NCT02118493
30 Evaluation of Surgical Risk in Elderly Patients Submitted to Elective Surgery: Comparative Study of Elective Vascular, Digestive and Biliary Surgery Withdrawn NCT00672698

Search NIH Clinical Center for Biliary Tract Disease

Cochrane evidence based reviews: biliary tract diseases

Genetic Tests for Biliary Tract Disease

Genetic tests related to Biliary Tract Disease:

# Genetic test Affiliating Genes
1 Biliary Tract Abnormality 29

Anatomical Context for Biliary Tract Disease

MalaCards organs/tissues related to Biliary Tract Disease:

Pancreas, Liver, Small Intestine, Eye, Spleen, Prostate

Publications for Biliary Tract Disease

Articles related to Biliary Tract Disease:

(show top 50) (show all 1640)
# Title Authors PMID Year
A case of idiopathic retroperitoneal fibrosis presenting as gallbladder carcinoma. 61
33765983 2021
The Differential Diagnosis of Intrahepatic Ductular Reaction in Medical Liver Biopsy. 61
33480600 2021
Developments in research on interstitial Cajal-like cells in the biliary tract. 61
32933347 2021
Laparoscopic SpyGlass cholangioscopy evaluation during bilioenteric anastomosis for hepatolithiasis, a case report. 61
33340982 2021
Bile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario. 61
33796547 2021
Epidemiological, Clinical, Microbiological, and Risk Factors of Pyogenic Liver Abscess: An 18-years Retrospective Single-Center Analysis. 61
33552413 2021
A Comparison of Osseous and Extraosseous Ewing Sarcoma. 61
33546529 2021
Etiology of Acute Recurrent Pancreatitis in Vietnamese Children: an Initial Report. 61
33603274 2020
Roles of Adipokines in Digestive Diseases: Markers of Inflammation, Metabolic Alteration and Disease Progression. 61
33167521 2020
Autoimmune Liver Disease in Patients With Sickle Cell Disease. 61
33181587 2020
Comparative analysis of epidemiology, etiology, and outcomes between elderly and young and middle-aged acute pancreatitis patients: a retrospective, single-center study. 61
33177384 2020
Management of pyogenic liver abscess: a South Australian experience. 61
32455495 2020
Multislice Computed Tomographic Manifestation of Transient Hepatic Attenuation Difference in the Left Lobe of the Liver: A Retrospective Study. 61
32715380 2020
Biochemical profile and gene expression of Clarias gariepinus as a signature of heavy metal stress. 61
32380399 2020
A retrospective study of pyogenic liver abscess caused primarily by Klebsiella pneumoniae vs. non-Klebsiella pneumoniae: CT and clinical differentiation. 61
31894381 2020
The Role of the Intestine in the Pathogenesis of Primary Sclerosing Cholangitis: Evidence and Therapeutic Implications. 61
32394535 2020
Liver Matrix in Benign and Malignant Biliary Tract Disease. 61
32162285 2020
Analysis of the clinical characteristics of 202 patients with liver abscess associated with diabetes mellitus and biliary tract disease. 61
32865074 2020
Patient Length of Stay Under the Two-Midnight Rule: Assessing the Accuracy of Providers' Predictions. 61
32639321 2020
The increased recurrence rate of liver abscess caused by extended-spectrum β-lactamase-producing Klebsiella pneumoniae. 61
32062726 2020
Comparison of the clinical characteristics and outcomes of bloodstream infections caused by Raoultella species and Klebsiella pneumoniae. 61
32362190 2020
A single-center analysis of primary nephrotic syndrome with acute pancreatitis in children. 61
32629733 2020
Treatment of hyperlipidemic acute pancreatitis with modified Dachengqi decoction combining with conventional therapy based on "six-hollow-organs to be unblocked" theory. 61
32692216 2020
Biliary disease and cholecystectomy after initiation of elexacaftor/ivacaftor/tezacaftor in adults with cystic fibrosis. 61
32736949 2020
Pyogenic Liver Abscess or Liver Cyst Infection after Colonoscopic Polypectomy. 61
32448861 2020
Applying Data Mining to Investigate Cancer Risk in Patients with Pyogenic Liver Abscess. 61
32455870 2020
Clinical and microbiological characteristics of patients with biliary disease. 61
32327912 2020
The role of bilirubin to albumin ratio as a predictor for mortality in critically ill patients without existing liver or biliary tract disease. 61
32131578 2020
16S rDNA microbiome composition pattern analysis as a diagnostic biomarker for biliary tract cancer. 61
31980025 2020
[Surgical treatment of malignant biliary tract diseases]. 61
31701167 2020
Risk of biliary tract disease in living liver donors: A population-based cohort study. 61
32226025 2020
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma. 61
33414994 2020
Imaging of Acute Hepatobiliary Dysfunction. 61
31731902 2020
Features of Marfan syndrome not listed in the Ghent nosology - the dark side of the disease. 61
31829751 2019
[Research progress in endoscopic retrograde cholangiopancreatography-mediated photodynamic therapy for cholangiocarcinoma]. 61
31919323 2019
Protective role of melatonin in early-stage and end-stage liver cirrhosis. 61
31475778 2019
Associations between ambient temperature and hepatobiliary and renal hospitalizations in California, 1999 to 2009. 61
31323396 2019
Activated cholangiocytes release macrophage-polarizing extracellular vesicles bearing the DAMP S100A11. 61
31365294 2019
Nal-IRI with 5-fluorouracil (5-FU) and leucovorin or gemcitabine plus cisplatin in advanced biliary tract cancer - the NIFE trial (AIO-YMO HEP-0315) an open label, non-comparative, randomized, multicenter phase II study. 61
31646981 2019
31460590 2019
[A consensus statement on the standardized application of antibacterial agents in biliary tract surgery (2019)]. 61
31269607 2019
Preoperative endoscopic retrograde cholangio-pancreatography (ERCP) is a risk factor for surgical site infections after laparoscopic cholecystectomy. 61
30473225 2019
The association between apolipoprotein E and gallstone disease: an updated meta-analysis. 61
31200656 2019
Development of a biliary multi-hole self-expandable metallic stent for bile tract diseases: A case report. 61
31236396 2019
[The new classifications of biliary tract diseases based on actual anatomy]. 61
31142064 2019
Biliary Tract Disease in Girls and Young Women With Rett Syndrome. 61
30664568 2019
Prognosis of liver abscess with no identified organism. 61
31151426 2019
[Clinical characteristics in patients with hypervirulent Klebsiella pneumoniae infection and its capsular serotypes and multilocus sequence typing]. 61
31060144 2019
[Differential diagnoses of biliary tract diseases : Computed tomography and magnetic resonance imaging]. 61
30820619 2019
[Percutaneous biliary and gallbladder interventions]. 61
30806733 2019

Variations for Biliary Tract Disease

ClinVar genetic disease variations for Biliary Tract Disease:

# Gene Name Type Significance ClinVarId dbSNP ID Position
1 C12orf60 , GUCY2C NM_004963.4(GUCY2C):c.410T>C (p.Leu137Ser) SNV Pathogenic 375380 rs1057519441 GRCh37: 12:14836177-14836177
GRCh38: 12:14683243-14683243

Expression for Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for Biliary Tract Disease

GO Terms for Biliary Tract Disease

Cellular components related to Biliary Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intercellular canaliculus GO:0046581 8.62 ABCB4 ABCB11

Biological processes related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.76 NR1I3 NR1I2 NR1H4 NR1H2
2 cholesterol homeostasis GO:0042632 9.69 NR1H4 NR1H2 ABCB11
3 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.61 MIR483 MIR199A1 MIR196A1
4 lipid homeostasis GO:0055088 9.58 NR1H2 ABCB4 ABCB11
5 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.54 MIR199A1 MIR17
6 bile acid metabolic process GO:0008206 9.52 NR1H4 ABCB11
7 bile acid signaling pathway GO:0038183 9.49 NR1H4 ABCC4
8 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.48 MIR199A1 MIR17
9 intracellular receptor signaling pathway GO:0030522 9.46 NR1I3 NR1I2 NR1H4 NR1H2
10 xenobiotic transport GO:0042908 9.43 NR1I2 ABCC4 ABCB11
11 cellular response to bile acid GO:1903413 9.37 NR1H4 ABCB4
12 miRNA mediated inhibition of translation GO:0035278 9.35 MIR483 MIR29A MIR222 MIR17 MIR145
13 positive regulation of cholesterol transport GO:0032376 9.32 NR1H2 ABCB4
14 gene silencing by miRNA GO:0035195 9.23 MIR483 MIR29A MIR222 MIR199A1 MIR196A1 MIR17

Molecular functions related to Biliary Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.33 ABCC4 ABCB4 ABCB11
2 retinoid X receptor binding GO:0046965 9.26 NR1H4 NR1H2
3 nuclear receptor activity GO:0004879 9.26 NR1I3 NR1I2 NR1H4 NR1H2
4 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.23 MIR483 MIR29A MIR222 MIR199A1 MIR196A1 MIR17

Sources for Biliary Tract Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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