MCID: BLR006
MIFTS: 51

Biliary Tract Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Biliary Tract Disease

MalaCards integrated aliases for Biliary Tract Disease:

Name: Biliary Tract Disease 12 15
Biliary Tract Diseases 44 73
Biliary Tract Abnormality 29

Classifications:



External Ids:

Disease Ontology 12 DOID:9741
ICD10 33 K83.9 K83.8
ICD9CM 35 576.9
MeSH 44 D001660
SNOMED-CT 68 5235004
UMLS 73 C0005424

Summaries for Biliary Tract Disease

MalaCards based summary : Biliary Tract Disease, also known as biliary tract diseases, is related to obstructive jaundice and cholecystitis, and has symptoms including digestive system symptom An important gene associated with Biliary Tract Disease is NR1H4 (Nuclear Receptor Subfamily 1 Group H Member 4), and among its related pathways/superpathways are Synthesis of bile acids and bile salts and NRF2 pathway. The drugs Vancomycin and Nefopam have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Biliary Tract Disease

Diseases related to Biliary Tract Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 obstructive jaundice 30.5 ALB GGT1 SLC25A13
2 cholecystitis 30.5 ABCB4 ALB CCK
3 cholangitis 30.3 ABCB11 ABCB4 ALB GGT1
4 cholelithiasis 30.1 ABCB4 ALB CCK CYP7A1 NR1H4
5 sclerosing cholangitis 30.0 ABCB11 ABCB4 ALB GGT1 NR1H4 NR1I2
6 cholangitis, primary sclerosing 29.8 ABCB4 ALB GGT1 KRT19 NR1I2
7 autosomal dominant non-syndromic intellectual disability 2 10.3 NR1I2 NR1I3
8 autosomal dominant non-syndromic intellectual disability 3 10.3 NR1I2 NR1I3
9 cholestasis, progressive familial intrahepatic, 5 10.3 NR1H4 NR1I2 NR1I3
10 atp8b1 deficiency 10.3 ABCB11 ATP8B1 NR1H4
11 cholestasis, progressive familial intrahepatic, 4 10.3 ABCB11 ABCB4 ATP8B1
12 cerebrotendinous xanthomatosis 10.3 CYP7A1 NR1H4 NR1I2
13 cholestasis, progressive familial intrahepatic, 3 10.3 ABCB11 ABCB4 ATP8B1
14 alagille syndrome 1 10.3 ABCB11 ABCB4 ATP8B1
15 cholestasis, benign recurrent intrahepatic, 1 10.3 ABCB11 ATP8B1 SLC10A1
16 cyclosporiasis 10.3 GGT1 GGT2
17 hyperbilirubinemia, rotor type 10.3 ABCC2 ALB
18 intrahepatic bile duct adenoma 10.3 KRT19 KRT7
19 cholecystolithiasis 10.3 ABCB4 CCK
20 anal gland adenocarcinoma 10.2 KRT19 KRT7
21 proliferating trichilemmal cyst 10.2 KRT19 KRT7
22 anus adenocarcinoma 10.2 KRT19 KRT7
23 algoneurodystrophy 10.2 GGT1 GGT2
24 cholestasis, progressive familial intrahepatic, 2 10.2 ABCB11 ABCB4 ATP8B1 NR1H4
25 renal pelvis adenocarcinoma 10.2 KRT19 KRT7
26 periampullary adenoma 10.2 GGT1 GGT2
27 dubin-johnson syndrome 10.2 ABCC2 ABCC3 ABCC4
28 cholestasis, progressive familial intrahepatic, 1 10.2 ABCB11 ABCB4 ATP8B1 NR1H4
29 pancreatic cystadenocarcinoma 10.2 GGT1 GGT2
30 cutaneous adenocystic carcinoma 10.2 KRT19 KRT7
31 ethmoid sinus cancer 10.2 GGT1 GGT2
32 ethmoid sinus adenocarcinoma 10.2 GGT1 GGT2
33 bladder carcinoma in situ 10.2 KRT19 KRT7
34 hepatic tuberculosis 10.2 ALB GGT1 GGT2
35 malignant leydig cell tumor 10.2 KRT19 KRT7
36 common bile duct disease 10.2 CCK GGT2
37 corneal abscess 10.2 KRT19 KRT7
38 gastrointestinal system cancer 10.2 ALB KRT19 KRT7
39 nasal cavity adenocarcinoma 10.2 CCK KRT7
40 progressive familial intrahepatic cholestasis 10.2 ABCB11 ABCB4 ABCC2 ATP8B1 NR1H4
41 eccrine adenocarcinoma 10.2 KRT19 KRT7
42 bilirubin metabolic disorder 10.2 ABCC2 ALB GGT1 NR1I3
43 colloid carcinoma of the pancreas 10.2 GGT1 GGT2 KRT19
44 autoimmune disease of urogenital tract 10.1 ABCB4 ALB GGT1 GGT2
45 biliary atresia 10.1 ALB ATP8B1 KRT7 NR1H4 SLC10A1
46 cholestasis, benign recurrent intrahepatic, 2 10.1 ABCB11 ATP8B1
47 anal canal adenocarcinoma 10.1 KRT19 KRT7
48 pancreatitis 10.1
49 chondroid lipoma 10.1 KRT19 KRT7
50 bile duct adenocarcinoma 10.1 ANXA8L1 KRT19 KRT7 PRRT2

Comorbidity relations with Biliary Tract Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Pancreatitis

Graphical network of the top 20 diseases related to Biliary Tract Disease:



Diseases related to Biliary Tract Disease

Symptoms & Phenotypes for Biliary Tract Disease

UMLS symptoms related to Biliary Tract Disease:


digestive system symptom

GenomeRNAi Phenotypes related to Biliary Tract Disease according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.66 ABCC3
2 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.66 GGT2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.66 ABCC3 GGT1 GGT2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.66 GGT2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.66 ABCB11 ABCC3 GGT1 GGT2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.66 ABCC3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.66 GGT1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.66 ABCC3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.66 ABCC3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.66 ABCC3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.66 ABCB11
12 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.66 GGT2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.66 ABCB11
14 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.66 GGT1 GGT2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.66 ABCB11
16 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.66 ABCB11

MGI Mouse Phenotypes related to Biliary Tract Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALB
2 behavior/neurological MP:0005386 9.96 ABCB11 ABCC3 ABCC4 CCK CYP7A1 GGT1
3 liver/biliary system MP:0005370 9.7 ABCB11 ABCB4 ABCC2 ABCC3 ALB ATP8B1
4 renal/urinary system MP:0005367 9.17 ABCC2 ABCC4 ALB CCK GGT1 KRT7

Drugs & Therapeutics for Biliary Tract Disease

Drugs for Biliary Tract Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 519)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vancomycin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1404-90-6 14969 441141
2 Nefopam Approved, Investigational Phase 4 13669-70-0
3
Ketamine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 6740-88-1 3821
4
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
5
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613
6
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 2078-54-8 4943
7 tannic acid Approved Phase 4,Phase 2,Not Applicable
8
Benzocaine Approved, Investigational Phase 4,Phase 2,Not Applicable 94-09-7, 1994-09-7 2337
9
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
10
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
11
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
12
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
13 Pinaverium Approved Phase 4,Not Applicable 59995-65-2
14
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
15
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
16
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 175805 71273
17
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
18
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
19
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
20
Etomidate Approved Phase 4 33125-97-2 667484 36339
21
Isoflurane Approved, Vet_approved Phase 4,Not Applicable 26675-46-7 3763
22
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
23
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
24
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
25
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 53608-75-6
26
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 128-13-2 31401
27
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
28
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
29
Acetaminophen Approved Phase 4 103-90-2 1983
30
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
31
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
32
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
33
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
34
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
35
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
36
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
37
Pseudoephedrine Approved Phase 4,Not Applicable 90-82-4 7028
38
Neostigmine Approved, Vet_approved Phase 4,Not Applicable 59-99-4 4456
39
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
40
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
41
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
42
Ephedrine Approved Phase 4,Not Applicable 299-42-3 9294
43
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
44
Ondansetron Approved Phase 4 99614-02-5 4595
45
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 54677470 5281106
46
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 443-48-1 4173
47
Secretin Approved Phase 4 108153-74-8
48
Abatacept Approved Phase 4 332348-12-6 10237
49
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
50
Tigecycline Approved Phase 4,Phase 1 220620-09-7 5282044

Interventional clinical trials:

(show top 50) (show all 1072)
# Name Status NCT ID Phase Drugs
1 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Unknown status NCT02605213 Phase 4 Vancomycin;Placebo
2 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
3 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Unknown status NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
4 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
5 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
6 The Discovery of the Double Sphincter in Gallbladder Unknown status NCT01998451 Phase 4 Tauroursodeoxycholic acid
7 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
8 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
9 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
10 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
11 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
12 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
13 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
14 Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
15 Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery Unknown status NCT02174575 Phase 4 Sevoflurane;Desflurane
16 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline;Ademethionine
17 Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis Unknown status NCT01998620 Phase 4 Ademetionine 2;Ademetionine 1;Ademetionine 3
18 Additional Effects of Perioperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy Unknown status NCT01969110 Phase 4
19 Effects of Preoperative Immunonutrition in Patients Undergoing Hepatectomy Unknown status NCT01256047 Phase 4
20 Cyclooxygenase-2 Inhibitor for Adjuvant Anticancer Effect in Patients With Biliary-pancreas Cancer Unknown status NCT01111591 Phase 4 Cox2 inhibitor (Celecoxib)
21 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
22 Spy II Clinical Registry Completed NCT00751998 Phase 4
23 Alfentanil Versus Remifentanil in Patient-controlled Sedation During Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT01350037 Phase 4 alfentanil;remifentanil
24 Effect IV Ibuprofen and Inflammatory Responses Completed NCT01938040 Phase 4 ibuprofen
25 The Usefulness of Endoscopic Ultrasound-guided Biliary Drainage With a Newly Designed Hybrid Metallic Stent Completed NCT01862198 Phase 4
26 A Study Comparing the Use of Deep or Standard Neuromuscular Blockade in Combination With Low or Standard Insufflation Pressures in Participants Undergoing Laparoscopic Cholecystectomy (P07982) Completed NCT01728584 Phase 4 Rocuronium;Sugammadex
27 Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. Completed NCT01709422 Phase 4 Propofol;Midazolam;Meperidine
28 Cocktail Sedation Containing Propofol Versus Conventional Sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT01540084 Phase 4 propofol
29 Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy Completed NCT01833819 Phase 4 Dexmedetomidine and lidocaine;Remifentanil
30 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
31 Vitamin C Efficacy in Reducing Post Operative Pain Completed NCT01322061 Phase 4 Ascorbic Acid
32 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
33 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
34 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
35 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
36 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
37 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
38 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
39 Clinical Study About the Role of COX-2 Inhibitor in Liver Cirrhosis With Biliary Atresia Completed NCT02298218 Phase 4 Meloxicam
40 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
41 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
42 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
43 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
44 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
45 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4 Rowachol;Placebo
46 Radiofrequency Ablation for Malignant Biliary Obstruction Completed NCT01758341 Phase 4
47 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
48 A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
49 Preventing Cholestasis Using SMOFLipid® Completed NCT01585935 Phase 4 SMOFLIPID;INTRALIPID
50 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4

Search NIH Clinical Center for Biliary Tract Disease

Cochrane evidence based reviews: biliary tract diseases

Genetic Tests for Biliary Tract Disease

Genetic tests related to Biliary Tract Disease:

# Genetic test Affiliating Genes
1 Biliary Tract Abnormality 29

Anatomical Context for Biliary Tract Disease

MalaCards organs/tissues related to Biliary Tract Disease:

41
Liver, Testes, Bone, Lung, Kidney, Testis, Thymus

Publications for Biliary Tract Disease

Articles related to Biliary Tract Disease:

(show top 50) (show all 342)
# Title Authors Year
1
Colonization, resistance to bile, and virulence properties of Escherichia coli strains: Unusual characteristics associated with biliary tract diseases. ( 28867623 )
2017
2
Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures: Retrospective Cohort Analysis of a US Population. ( 26706861 )
2016
3
Single-incision laparoscopic surgery for biliary tract disease. ( 26811621 )
2016
4
Risk and Surveillance of Cancers in Primary Biliary Tract Disease. ( 27413366 )
2016
5
Primary Sclerosing Cholangitis as a Premalignant Biliary Tract Disease: Surveillance and Management. ( 26051390 )
2015
6
Type II diabetes mellitus is associated with a reduced risk of cholangiocarcinoma in patients with biliary tract diseases. ( 25348605 )
2015
7
MicroRNAs and benign biliary tract diseases. ( 25632932 )
2015
8
Asbestos fibers in the gallbladder of patients affected by benign biliary tract diseases. ( 25856690 )
2015
9
Current status of peroral cholangioscopy in biliary tract diseases. ( 25992189 )
2015
10
Novel Serum Biomarkers to Differentiate Cholangiocarcinoma from Benign Biliary Tract Diseases Using a Proteomic Approach. ( 26060332 )
2015
11
Recurrent pyogenic cholangitis as a differential diagnosis in biliary tract diseases. ( 26367025 )
2015
12
Advanced Imaging Technology in Biliary Tract Diseases:Narrow-Band Imaging of the Bile Duct. ( 26668795 )
2015
13
Body mass index and biliary tract disease: a systematic review and meta-analysis of prospective studies. ( 24721739 )
2014
14
Ketamine abuse, biliary tract disease, and secondary sclerosing cholangitis. ( 23695896 )
2013
15
Impact of an acute care surgery model with a dedicated daytime operating room on outcomes and timeliness of care in patients with biliary tract disease. ( 23756774 )
2013
16
Cholangioscopy using a new type of cholangioscope for the diagnosis of biliary tract disease: a case series. ( 22814962 )
2012
17
Prognostic relevance of circulating CK19 mRNA in advanced malignant biliary tract diseases. ( 22253524 )
2012
18
Role of intraoperative flexible Choledochoscopy in calculous biliary tract disease. ( 22828544 )
2012
19
Transgastric endoscopic retrograde cholangiopancreatography for the management of biliary tract disease after Roux-en-Y gastric bypass treatment for obesity. ( 22460551 )
2012
20
Endoscopic diagnosis of biliary tract disease. ( 22343346 )
2012
21
Novel biopsy forceps for diagnosis of biliary tract diseases during endoscopic retrograde cholangiopancreatography: a prospective comparative study with 90° adjustable and conventional biopsy forceps. ( 22094996 )
2012
22
Lack of association between Helicobacter pylori infection and biliary tract diseases. ( 23484417 )
2012
23
A stunning year for advances in biliary tract disease. ( 21423005 )
2011
24
Imaging of biliary tract disease. ( 21940525 )
2011
25
Peroral cholangioscopy for diagnosis and therapy of biliary tract disease using an ultra-slim gastroscope. ( 21823068 )
2011
26
Covered self-expandable metal stents for benign biliary tract diseases. ( 21248636 )
2011
27
Successful off-label use of enteral stents in uncommon complicated biliary tract diseases. ( 21457820 )
2011
28
Serum NGAL to Clinically Distinguish Cholangiocarcinoma from Benign Biliary Tract Diseases. ( 21994874 )
2011
29
Management of biliary tract disease during pregnancy. ( 20193902 )
2010
30
Vascular factors, angiogenesis and biliary tract disease. ( 20061944 )
2010
31
Endoscopic retrograde cholangiopancreatography in pancreatic and biliary tract disease in Korean children. ( 20101777 )
2010
32
The role of international classification of diseases in assessment of patients with biliary tract disease. ( 19745312 )
2009
33
Farnesoid X receptor agonists in biliary tract disease. ( 19300246 )
2009
34
Minimally invasive management of acute biliary tract disease during pregnancy. ( 19606252 )
2009
35
Chlamydia infection as risk factor for pediatric biliary tract disease. ( 18334886 )
2008
36
Double-balloon enteroscopy application in biliary tract disease-its therapeutic and diagnostic functions. ( 18561917 )
2008
37
Management of biliary tract disease during pregnancy: a decision analysis. ( 17713817 )
2008
38
Novel endoscopic approaches for assessing biliary tract diseases. ( 18408465 )
2008
39
Genetics of biliary tract diseases: new insights into gallstone disease and biliary tract cancers. ( 18408466 )
2008
40
Peroral cholangioscopic diagnosis of biliary-tract diseases by using narrow-band imaging (with videos). ( 17905015 )
2007
41
Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathy. ( 17063088 )
2006
42
Endoscopic treatment of biliary tract disease prior to orthotopic liver transplantation. ( 16539874 )
2006
43
Biliary tract disease as a risk factor for Plesiomonas shigelloides bacteraemia: a nine-year experience in a Hong Kong hospital and review of the literature. ( 15782626 )
2005
44
A bile based study of Clonorchis sinensis infections in patients with biliary tract diseases in Ulsan, Korea. ( 16385655 )
2005
45
Bacteriuria in patients with gallbladder and biliary tract diseases. ( 16295397 )
2004
46
Medical versus surgical management of biliary tract disease in pregnancy. ( 15619495 )
2004
47
Reoperation for benign biliary tract diseases in 149 cases: causes and prevention. ( 15138123 )
2004
48
C-reactive protein in patients with gallbladder and biliary tract diseases. ( 15471320 )
2004
49
Helicobacter pylori and the risk of benign and malignant biliary tract disease. ( 12879485 )
2003
50
Gallbladder and biliary tract disease in the intensive care unit. ( 12610852 )
2003

Variations for Biliary Tract Disease

Expression for Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for Biliary Tract Disease

Pathways related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 ABCB11 ABCC3 ALB CYP7A1 NR1H4 SLC10A1
2 11.93 ABCC2 ABCC3 ABCC4 GGT1 GGT2
3
Show member pathways
11.9 ABCB11 ABCB4 ABCC2 SLC10A1
4
Show member pathways
11.7 NR1H4 NR1I2 NR1I3
5
Show member pathways
11.67 ABCB11 ABCC2 ABCC4
6
Show member pathways
11.62 ABCC2 ABCC3 ABCC4
7 11.61 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 CYP7A1
8
Show member pathways
11.51 ABCC2 NR1I2 NR1I3
9 11.18 ABCC2 ABCC3 NR1I3
10 11.14 ABCC2 ABCC3 ABCC4
11 11.01 ABCC2 ABCC3 ABCC4
12 10.95 GGT1 GGT2
13 10.93 ABCB11 ABCB4 CYP7A1 NR1H4 SLC10A1
14
Show member pathways
10.91 ABCC2 ABCC3 ABCC4
15 10.84 ABCC2 ABCC3 ABCC4
16 10.84 ABCB11 ABCC2 ABCC3 ABCC4 CYP7A1 NR1H4
17 10.77 ABCB11 ABCB4 ABCC2 ABCC3 CYP7A1 NR1H4
18 10.76 ABCC3 NR1I2
19 10.69 ABCC2 NR1I2
20 10.54 ABCC2 ABCC3

GO Terms for Biliary Tract Disease

Cellular components related to Biliary Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.7 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 SLC10A1
2 RNA polymerase II transcription factor complex GO:0090575 9.13 NR1H4 NR1I2 NR1I3
3 intercellular canaliculus GO:0046581 8.8 ABCB11 ABCB4 ABCC2

Biological processes related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.8 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 SLC10A1
2 steroid hormone mediated signaling pathway GO:0043401 9.63 NR1H4 NR1I2 NR1I3
3 intracellular receptor signaling pathway GO:0030522 9.58 NR1H4 NR1I2 NR1I3
4 glutamate metabolic process GO:0006536 9.57 GGT1 GGT2
5 zymogen activation GO:0031638 9.56 GGT1 GGT2
6 bile acid metabolic process GO:0008206 9.55 ATP8B1 NR1H4
7 glutathione catabolic process GO:0006751 9.54 GGT1 GGT2
8 leukotriene D4 biosynthetic process GO:1901750 9.52 GGT1 GGT2
9 cysteine biosynthetic process GO:0019344 9.51 GGT1 GGT2
10 drug transmembrane transport GO:0006855 9.5 ABCB4 ABCC2 ATP8B1
11 xenobiotic transport GO:0042908 9.49 ABCB4 NR1I2
12 regulation of immune system process GO:0002682 9.48 GGT1 GGT2
13 regulation of bile acid biosynthetic process GO:0070857 9.43 CYP7A1 NR1H4
14 peptide modification GO:0031179 9.37 GGT1 GGT2
15 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.33 ABCC2 ABCC3 ABCC4
16 canalicular bile acid transport GO:0015722 9.13 ABCB11 ABCC2 ABCC3
17 bile acid and bile salt transport GO:0015721 9.02 ABCB11 ABCC3 ATP8B1 NR1H4 SLC10A1

Molecular functions related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.72 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4
2 transmembrane transporter activity GO:0022857 9.7 ABCC2 ABCC3 SLC25A13
3 transcription regulatory region sequence-specific DNA binding GO:0000976 9.67 NR1H4 NR1I2 NR1I3
4 nuclear receptor transcription coactivator activity GO:0030374 9.63 NR1H4 NR1I2 NR1I3
5 steroid hormone receptor activity GO:0003707 9.61 NR1H4 NR1I2 NR1I3
6 nuclear receptor activity GO:0004879 9.54 NR1H4 NR1I2 NR1I3
7 organic anion transmembrane transporter activity GO:0008514 9.51 ABCC2 ABCC3
8 glutathione hydrolase activity GO:0036374 9.48 GGT1 GGT2
9 peptidyltransferase activity GO:0000048 9.4 GGT1 GGT2
10 ATPase-coupled anion transmembrane transporter activity GO:0043225 9.33 ABCC2 ABCC3 ABCC4
11 bile acid-exporting ATPase activity GO:0015432 9.26 ABCB11 ABCC3
12 thyroid hormone receptor activity GO:0004887 9.13 NR1H4 NR1I2 NR1I3
13 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.02 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4

Sources for Biliary Tract Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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