Biliary Tract Disease

Categories: Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Biliary Tract Disease

MalaCards integrated aliases for Biliary Tract Disease:

Name: Biliary Tract Disease 12 15 17
Biliary Tract Diseases 43 71
Biliary Tract Abnormality 29


External Ids:

Disease Ontology 12 DOID:9741
ICD9CM 34 576.9
MeSH 43 D001660
SNOMED-CT 67 5235004
ICD10 32 K83.8 K83.9
UMLS 71 C0005424

Summaries for Biliary Tract Disease

MalaCards based summary : Biliary Tract Disease, also known as biliary tract diseases, is related to cholangitis and cholelithiasis, and has symptoms including digestive system symptom An important gene associated with Biliary Tract Disease is NR1H4 (Nuclear Receptor Subfamily 1 Group H Member 4), and among its related pathways/superpathways are MicroRNAs in cancer and Nuclear Receptor transcription pathway. The drugs Propofol and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and pancreas.

Related Diseases for Biliary Tract Disease

Diseases in the Biliary Tract Disease family:

Rare Biliary Tract Disease

Diseases related to Biliary Tract Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 262)
# Related Disease Score Top Affiliating Genes
1 cholangitis 32.0 NR1I2 NR1H4 MIR222 GPT ABCB4 ABCB11
2 cholelithiasis 31.9 NR1H4 GPT ABCB4
3 choledocholithiasis 31.9 MIR222 GPT ABCB4
4 cholestasis 31.5 NR1I3 NR1I2 NR1H4 NR1H2 GPT ABCC4
5 sclerosing cholangitis 31.5 NR1I2 NR1H4 MIR483 MIR222 GPT ABCB4
6 liver disease 31.4 NR1I2 NR1H4 GPT ABCB4 ABCB11
7 biliary atresia 31.4 NR1H4 GPT ABCB4 ABCB11
8 gallbladder disease 31.3 NR1H4 MIR222 MIR199A1 MIR145 GPT ABCB4
9 cholangitis, primary sclerosing 31.3 NR1I2 NR1H4 MIR483 MIR222 MIR145 GPT
10 primary biliary cirrhosis 31.2 NR1I3 NR1I2 NR1H4 MIR483 MIR150 GPT
11 bile duct cysts 31.0 GPT ABCB4 ABCB11
12 extrahepatic cholestasis 31.0 NR1H4 GPT ABCB4 ABCB11
13 suppurative cholangitis 30.9 GPT ABCB4
14 bile duct cancer 30.9 MIR483 MIR31 MIR199A1 MIR150 GPT
15 alcohol use disorder 30.7 MIR199A1 H2AC18 GPT CCR6
16 pancreas disease 30.7 MIR486-1 MIR483 MIR31 MIR199A1 MIR196A1 MIR150
17 pancreatic cancer 30.6 MIR483 MIR222 MIR199A1 MIR196A1 MIR150 MIR148A
18 bladder disease 30.5 MIR486-1 MIR31 MIR199A1 MIR196A1 MIR150 MIR145
19 gastrointestinal system disease 30.5 MIR486-1 MIR483 MIR31 MIR29A MIR222 MIR199A1
20 bile duct disease 30.4 NR1I2 NR1H4 MIR486-1 MIR483 MIR31 MIR29A
21 hepatocellular carcinoma 30.1 NR1H4 MIR483 MIR31 MIR29A MIR222 MIR199A1
22 genetic biliary tract disease 12.4
23 rare biliary tract disease 12.4
24 cholestasis, progressive familial intrahepatic, 5 10.8 NR1I3 NR1H4 ABCB11
25 familial intrahepatic cholestasis 10.8 NR1H4 ABCB4 ABCB11
26 atp8b1 deficiency 10.8 NR1H4 ABCB11
27 autosomal dominant non-syndromic intellectual disability 3 10.8 NR1I2 ABCB4 ABCB11
28 bile acid synthesis defect, congenital, 2 10.8 NR1I3 NR1I2 NR1H4 ABCB11
29 cholestasis, progressive familial intrahepatic, 2 10.7 NR1H4 ABCC4 ABCB4 ABCB11
30 cholestasis, benign recurrent intrahepatic, 2 10.7 NR1H4 ABCB4 ABCB11
31 cholestasis, progressive familial intrahepatic, 3 10.7 NR1H4 ABCB4 ABCB11
32 hepatic vascular disease 10.7 NR1H4 MIR199A1 GPT CCR6
33 progressive familial intrahepatic cholestasis 10.7 NR1H4 ABCC4 ABCB4 ABCB11
34 cerebrotendinous xanthomatosis 10.7 NR1I2 NR1H4 NR1H2
35 common bile duct disease 10.7 MIR222 GPT ABCB4
36 acute porphyria 10.7 NR1I3 NR1I2 NR1H2
37 parenteral nutrition-associated cholestasis 10.7 GPT ABCB4
38 cholestasis, progressive familial intrahepatic, 1 10.7 NR1H4 ABCB4 ABCB11
39 cecal disease 10.7 H2AC18 GPT CCR6
40 ovarian serous carcinoma 10.7 MIR29A MIR199A1 MIR145
41 bone resorption disease 10.7 MIR222 MIR199A1 H2AC18 CCR6
42 bilirubin metabolic disorder 10.7 NR1I3 GPT ABCC4 ABCB4 ABCB11
43 ampulla of vater adenocarcinoma 10.7 MIR222 MIR196A1 MIR145
44 intestinal benign neoplasm 10.7 MIR31 MIR199A1 H2AC18 CCR6
45 skeletal muscle cancer 10.7 MIR486-1 MIR199A1 MIR196A1 H2AC18
46 muscle cancer 10.7 MIR486-1 MIR199A1 MIR196A1 H2AC18
47 splenic disease 10.7 H2AC18 GPT CCR6
48 lipid storage disease 10.7 NR1H4 MIR199A1 H2AC18 GPT CCR6
49 inherited metabolic disorder 10.7 NR1H4 MIR199A1 H2AC18 GPT CCR6
50 lymphatic system disease 10.7 MIR483 MIR150 H2AC18 CCR6

Comorbidity relations with Biliary Tract Disease via Phenotypic Disease Network (PDN):

Acute Cystitis Acute Pancreatitis

Graphical network of the top 20 diseases related to Biliary Tract Disease:

Diseases related to Biliary Tract Disease

Symptoms & Phenotypes for Biliary Tract Disease

UMLS symptoms related to Biliary Tract Disease:

digestive system symptom

Drugs & Therapeutics for Biliary Tract Disease

Drugs for Biliary Tract Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Remifentanil Approved Phase 4 132875-61-7 60815
Acetaminophen Approved Phase 4 103-90-2 1983
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
6 Hypnotics and Sedatives Phase 4
7 Anesthetics Phase 4
8 Anesthetics, General Phase 4
9 Anesthetics, Intravenous Phase 4
10 Central Nervous System Depressants Phase 4
11 Narcotics Phase 4
12 Analgesics, Opioid Phase 4
13 Analgesics Phase 4
Trioxsalen Approved Phase 2, Phase 3 3902-71-4 5585
Tamoxifen Approved Phase 3 10540-29-1 2733526
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
Octreotide Approved, Investigational Phase 3 83150-76-9 383414 6400441
Sodium citrate Approved, Investigational Phase 3 68-04-2
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
21 Hematoporphyrin Derivative Phase 2, Phase 3
22 Photosensitizing Agents Phase 2, Phase 3
23 Dihematoporphyrin Ether Phase 2, Phase 3
24 Immunosuppressive Agents Phase 3
25 Immunologic Factors Phase 3
26 Gastrointestinal Agents Phase 3
27 Antibiotics, Antitubercular Phase 3
28 Anti-Bacterial Agents Phase 3
29 Estrogens Phase 3
30 Alkylating Agents Phase 3
31 Selective Estrogen Receptor Modulators Phase 3
32 Hormone Antagonists Phase 3
33 Citrate Phase 3
34 Topoisomerase Inhibitors Phase 3
Liposomal doxorubicin Phase 3 31703
36 Antirheumatic Agents Phase 3
37 Estrogen Receptor Antagonists Phase 3
38 Estrogen Antagonists Phase 3
39 Antineoplastic Agents, Hormonal Phase 3
40 Estrogen Receptor Modulators Phase 3
41 Hormones Phase 3
42 Hematinics Phase 3
43 Liver Extracts Phase 3
44 Pharmaceutical Solutions Phase 3
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
Fluorouracil Approved Phase 2 51-21-8 3385
leucovorin Approved Phase 2 58-05-9 6006 143
Gemcitabine Approved Phase 2 95058-81-4 60750
Ursodeoxycholic acid Approved, Investigational Phase 2 128-13-2 31401
50 Vasodilator Agents Phase 2

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 A Clinical Registry to Assess Performance and Clinical Utility of the SpyGlass Direct Visualization System Completed NCT00751998 Phase 4
2 Alfentanil vs Remifentanil in Patient-controlled Sedation During ERCP.A Randomized Double-blind Study Completed NCT01350037 Phase 4 alfentanil;remifentanil
3 A Randomized Controlled Trial Comparing Endoscopic Biliary Radiofrequency Ablation With Photodynamic Therapy for Inoperable Cholangiocarcinoma Unknown status NCT01739465 Phase 2, Phase 3
4 Effect of Saline Irrigation to Decrease Rate of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
5 An Expertise-based Randomized Controlled Trial Comparing Minilaparotomy Cholecystectomy and Laparoscopic Cholecystectomy Completed NCT00370344 Phase 2, Phase 3
6 A Clinical Trial to Evaluate the Benefit of Adding Octreotide (SMS 201-995 PA LAR) to Tamoxifen Alone or to Tamoxifen and Chemotherapy in Patients With Axillary Node-Negative, Estrogen-Receptor-Positive, Primary Invasive Breast Cancer Completed NCT00002967 Phase 3 cyclophosphamide;doxorubicin hydrochloride;octreotide pamoate;tamoxifen citrate
7 MRX-502: Randomized Double-blind Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety of Maralixibat in the Treatment of Subjects With Progressive Familial Intrahepatic Cholestasis (PFIC) - MARCH-PFIC Recruiting NCT03905330 Phase 3 Maralixibat
8 A Multicenter Randomized Controlled Trial to Compare the Efficacy of End-ischemic Dual Hypothermic Oxygenated Perfusion With Standard Static Cold Storage of Liver Grafts Donated After Circulatory Death in Preventing Biliary Complications Recruiting NCT02584283 Phase 3 Glutathione
9 An Open-label Extension Study to Evaluate the Long-term Safety and Efficacy of Maralixibat in the Treatment of Subjects With Progressive Familial Intrahepatic Cholestasis (PFIC) Not yet recruiting NCT04185363 Phase 3 Maralixibat
10 Treatment of Suspected Cholelithiasis With Nitroglycerin: a Randomized, Prospective Double-blind Trial Unknown status NCT01715220 Phase 2 sublingual nitroglycerine
11 Effect of a Fatty Meal on Cannulation at Endoscopic Retrograde Cholangiopancreatography Completed NCT00124202 Phase 1, Phase 2
12 Prospective Phase II Randomized Trial-Weekly Gemcitabine Plus High-Dose 5-Fluorouracil/ Leucovorin in the Treatment of Advanced or Metastatic Carcinoma of the Biliary Tract Completed NCT00201305 Phase 2 Gemcitabine+5FU+Leucovorin
13 Transvaginal Natural Orifice Translumenal and Endoscopic Surgery (NOTES) Cholecystectomy vs. Laparoscopic Cholecystectomy: Phase I/II Clinical Trial Completed NCT00710502 Phase 1, Phase 2
14 A Phase 2, Randomized, Double-Blind Study of HTD1801 vs Ursodeoxycholic Acid (UDCA) in Adolescents With Primary Sclerosing Cholangitis (PSC) Not yet recruiting NCT03678480 Phase 2 HTD1801;Ursodeoxycholic Acid
15 MRX-800: A Long-Term Safety Study of Maralixibat, an Apical Sodium Dependent Bile Acid Transporter Inhibitor (ASBTi), in the Treatment of Cholestatic Liver Disease in Subjects Who Previously Participated in a Maralixibat Study Not yet recruiting NCT04168385 Phase 2 Maralixibat
16 A Phase 2, Randomized, Double Blind, Placebo Controlled, Multiple Center Study to Evaluate the Safety, Tolerability, and Efficacy of Seladelpar Administered for 24 Weeks in Adult Patients With Primary Sclerosing Cholangitis (PSC) Suspended NCT04024813 Phase 2 Seladelpar;Placebo to match Seladelpar
17 Safety and Efficacy Study of IL-10 (Tenovil TM) in the Prevention of Post-ERCP Acute Pancreatitis (Study P02580)(TERMINATED) Terminated NCT00040131 Phase 2 IL-10
18 A Network on the Quality of ERCP, on the Organization of the Endoscopic Units and on the Training of the Endoscopists in Italy Unknown status NCT02971579
19 Comparison Between Continuous Infusion and Intermittent Bolus Injection of Propofol for Deep Sedation During Endoscopic Retrograde Cholangiopancreatography: a Prospective Randomized Controlled Study Unknown status NCT01900938 Midazolam;Propofol
20 Zhujiang Hospital of the Southern Medical University Unknown status NCT03074708
21 An Evaluation of the Utility of the ExSpiron Respiratory Variation Monitor During Upper GI Endoscopy Unknown status NCT02310230
22 Prospective Evaluation of the Clinical Utility of Endoscopic Retrograde Cholangiopancreatography (ERCP) Guided Cholangiopancreatoscopy With the SpyGlass DS. Completed NCT02524418
23 Clinical Registry of Cholangioscopy Using the SpyGlass™ Direct Visualization System Throughout China Completed NCT02287194
24 A Multicenter Randomized Trial Comparing the Use of Touch and no Touch Guide-wire Techniques for Deep Biliary Cannulation: the TNT Study Completed NCT01954602
25 Endoscopic Treatment of Benign Biliary Strictures and Cystic Duct Leakages With a Novel Biodegradable Polydioxanone Biliary Stent Completed NCT02353286
26 Biodegradable Stent Implantation in Biliary Benign Strictures. Spanish Register. Completed NCT04115696
27 Use of Serum Proteome on the Early Diagnosis of Malignant Biliary-Pancreatic Disease Completed NCT00559598
28 Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method in Patients With High Risk of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Multicenter Randomized Controlled Trial Completed NCT02916199
29 Safety and Efficacy of n-3 Fatty Acid-based Parenteral Nutrition in Patients With Obstructive Jaundice: A Propensity-matched Study Completed NCT03376945 trail cohort;control cohort
30 The Role of Antibiotic Treatment in Patients With Acute Mild Cholecystitis - A Prospective Randomized Controlled Trial Completed NCT00557453 Antibiotic treatment;No antibiotics
31 Sahlgrenska EUS ERCP Study Recruiting NCT03504293
32 Comparison of Standard Endotracheal Intubation [SEI] and Endoscope Assisted Endotracheal Intubation [EAE] Recruiting NCT03879720
33 A Prospective Study: Magnetic Compression Anastomosis for Recanalization of Biliary Stricture Recruiting NCT04170933
34 Gastrointestinal Microbiomes in Patients of Recurrent Common Bile Duct Stones After Endoscopic Sphincterotomy(EST) Recruiting NCT03102281
35 CO2 Cholangiography as an Alternative to Iodinated Contrast in Endoscopic Retrograde Cholangiopancreatography Recruiting NCT02611453
36 Is Needle Knife Fistulotomy An Effective First Step Strategy For All ERCPs? Recruiting NCT03698266
37 Assessment of Cholangio-pancreatoscopy for the Diagnosis and the Treatment of Biliary and Pancreatic Diseases Trial " EASYSPY " Active, not recruiting NCT03190343
38 Endoscopic Ultrasound Guided Rendezvous or Direct Interventions Versus Advanced ERCP Techniques for Biliary Access and Therapy Active, not recruiting NCT01678326
40 Prospective Observational Study of Primary Sclerosing Cholangitis (PSC) in Children Not yet recruiting NCT04181138
41 Endo-biliary Laser Excision of Biliary Stenoses: Initial Experience and Feasibility Withdrawn NCT02118493
42 Evaluation of Surgical Risk in Elderly Patients Submitted to Elective Surgery: Comparative Study of Elective Vascular, Digestive and Biliary Surgery Withdrawn NCT00672698

Search NIH Clinical Center for Biliary Tract Disease

Cochrane evidence based reviews: biliary tract diseases

Genetic Tests for Biliary Tract Disease

Genetic tests related to Biliary Tract Disease:

# Genetic test Affiliating Genes
1 Biliary Tract Abnormality 29

Anatomical Context for Biliary Tract Disease

MalaCards organs/tissues related to Biliary Tract Disease:

Liver, Testes, Pancreas, Bone, Kidney, Thyroid, Breast

Publications for Biliary Tract Disease

Articles related to Biliary Tract Disease:

(show top 50) (show all 1605)
# Title Authors PMID Year
Imaging of Acute Hepatobiliary Dysfunction. 61
31731902 2020
A retrospective study of pyogenic liver abscess caused primarily by Klebsiella pneumoniae vs. non-Klebsiella pneumoniae: CT and clinical differentiation. 61
31894381 2020
16S rDNA microbiome composition pattern analysis as a diagnostic biomarker for biliary tract cancer. 61
31980025 2020
[Surgical treatment of malignant biliary tract diseases]. 61
31701167 2020
Features of Marfan syndrome not listed in the Ghent nosology - the dark side of the disease. 61
31829751 2019
[Research progress in endoscopic retrograde cholangiopancreatography-mediated photodynamic therapy for cholangiocarcinoma]. 61
31919323 2019
Protective role of melatonin in early-stage and end-stage liver cirrhosis. 61
31475778 2019
Associations between ambient temperature and hepatobiliary and renal hospitalizations in California, 1999 to 2009. 61
31323396 2019
Activated cholangiocytes release macrophage-polarizing extracellular vesicles bearing the DAMP S100A11. 61
31365294 2019
Nal-IRI with 5-fluorouracil (5-FU) and leucovorin or gemcitabine plus cisplatin in advanced biliary tract cancer - the NIFE trial (AIO-YMO HEP-0315) an open label, non-comparative, randomized, multicenter phase II study. 61
31646981 2019
31460590 2019
[A consensus statement on the standardized application of antibacterial agents in biliary tract surgery (2019)]. 61
31269607 2019
Preoperative endoscopic retrograde cholangio-pancreatography (ERCP) is a risk factor for surgical site infections after laparoscopic cholecystectomy. 61
30473225 2019
The association between apolipoprotein E and gallstone disease: an updated meta-analysis. 61
31200656 2019
Development of a biliary multi-hole self-expandable metallic stent for bile tract diseases: A case report. 61
31236396 2019
[The new classifications of biliary tract diseases based on actual anatomy]. 61
31142064 2019
Biliary Tract Disease in Girls and Young Women With Rett Syndrome. 61
30664568 2019
Prognosis of liver abscess with no identified organism. 61
31151426 2019
[Clinical characteristics in patients with hypervirulent Klebsiella pneumoniae infection and its capsular serotypes and multilocus sequence typing]. 61
31060144 2019
[Differential diagnoses of biliary tract diseases : Computed tomography and magnetic resonance imaging]. 61
30820619 2019
A cohort study of age and sex specific risk of pyogenic liver abscess incidence in patients with type 2 diabetes mellitus. 61
31027123 2019
[Percutaneous biliary and gallbladder interventions]. 61
30806733 2019
Re-admission patterns in England and the Netherlands: a comparison based on administrative data of all hospitals. 61
30445564 2019
Predictors of Clostridioides difficile recurrence across a national cohort of veterans in outpatient, acute, and long-term care settings. 61
31361830 2019
Recurrent retroperitoneal abscess after biliary tract surgery in an elderly patient: a minimally invasive nonsurgical approach and its consequences: a case report. 61
30798788 2019
How Would You Treat This Patient With Gallstone Pancreatitis?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. 61
30716756 2019
Epidemiology of Pediatric Acute Pancreatitis in Taiwan: A Nationwide Population-based Study. 61
30358742 2019
Complications of Solid Organ Transplantation: Cardiovascular, Neurologic, Renal, and Gastrointestinal. 61
30447778 2019
Hematopoietic Stem Cell Transplantation for Combined Immunodeficiencies, on Behalf of IEWP-EBMT. 61
32039114 2019
Efficacy and safety of Yinchen Sini decoction in treating biliary atresia patients after Kasai portoenterostomy: A systematic review and meta-analysis protocol. 61
30633169 2019
Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018. 61
30315778 2019
Perspective for evaluation of microrna in plasma and bile for differential diagnosis of obstructive biliary tract disease. 61
31398176 2019
The microbiota of the bilio-pancreatic system: a cohort, STROBE-compliant study. 61
31354308 2019
Gallbladder agenesis with hepatic impairment: a case report. 61
30454006 2018
The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer. 61
30451962 2018
Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review. 61
30015401 2018
Burden of gastrointestinal and liver diseases in India, 1990-2016. 61
30306342 2018
Fitz-Hugh-Curtis syndrome in a man positive for Chlamydia trachomatis. 61
29417387 2018
Safety and efficacy of n-3 fatty acid-based parenteral nutrition in patients with obstructive jaundice: a propensity-matched study. 61
30006616 2018
[Analysis of related factors for hepatic alveolar echinococcosis and gallbladder complications of children in Qinghai Province]. 61
30891975 2018
The diagnostic value of five serum tumor markers for patients with cholangiocarcinoma. 61
29438681 2018
How the biliary tree maintains immune tolerance? 61
28844953 2018
Outcome of elective cholecystectomy for the treatment of gallbladder disease in dogs. 61
29595398 2018
Novel ex vivo training model for freehand insertion using a double-bending peroral direct cholangioscope. 61
28688125 2018
Isolation of Extracellular RNA from Bile. 61
29388136 2018
[Síndrome de Fitz-Hugh-Curtis en un paciente varón anciano. Caso y revisión de la literatura]. 61
30226491 2018
Metastatic Pancreatic Adenocarcinoma Presenting as a Klatskin Tumor. 61
30568968 2018
Characterization of biofilms in biliary stents and potential factors involved in occlusion. 61
29358888 2018
Cholangioscopy in the digital era. 61
30505969 2018
Newly Diagnosed Idiopathic Liver Abscess: Colonoscopy Required! 61
29038677 2017

Variations for Biliary Tract Disease

Expression for Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for Biliary Tract Disease

GO Terms for Biliary Tract Disease

Cellular components related to Biliary Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 MIR486-1 MIR31 MIR29A MIR222 MIR199A1 MIR150
2 intercellular canaliculus GO:0046581 8.96 ABCB4 ABCB11
3 RNA polymerase II transcription factor complex GO:0090575 8.92 NR1I3 NR1I2 NR1H4 NR1H2

Biological processes related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.91 NR1I3 NR1I2 NR1H4 NR1H2 ABCB4
2 cellular response to lipopolysaccharide GO:0071222 9.76 NR1I3 NR1I2 NR1H4 NR1H2
3 transcription initiation from RNA polymerase II promoter GO:0006367 9.73 NR1I3 NR1I2 NR1H4 NR1H2
4 steroid hormone mediated signaling pathway GO:0043401 9.67 NR1I3 NR1I2 NR1H4 NR1H2
5 cholesterol homeostasis GO:0042632 9.65 NR1I3 NR1I2 NR1H4 NR1H2 MIR148A
6 miRNA mediated inhibition of translation GO:0035278 9.63 MIR483 MIR31 MIR29A MIR222 MIR148A MIR145
7 intracellular receptor signaling pathway GO:0030522 9.62 NR1I3 NR1I2 NR1H4 NR1H2
8 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.52 MIR199A1 MIR148A
9 xenobiotic transport GO:0042908 9.49 NR1I2 ABCC4
10 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.48 MIR31 MIR222
11 lipid homeostasis GO:0055088 9.43 NR1I3 NR1I2 NR1H4 NR1H2 MIR148A ABCB4
12 positive regulation of cholesterol transport GO:0032376 9.4 NR1H2 ABCB4
13 gene silencing by miRNA GO:0035195 9.28 MIR483 MIR31 MIR29A MIR222 MIR199A1 MIR196A1

Molecular functions related to Biliary Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.77 NR1I3 NR1I2 NR1H4 NR1H2 CCR6
2 transcription regulatory region sequence-specific DNA binding GO:0000976 9.62 NR1I3 NR1I2 NR1H4 NR1H2
3 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.58 ABCC4 ABCB4 ABCB11
4 nuclear receptor transcription coactivator activity GO:0030374 9.56 NR1I3 NR1I2 NR1H4 NR1H2
5 steroid hormone receptor activity GO:0003707 9.46 NR1I3 NR1I2 NR1H4 NR1H2
6 retinoid X receptor binding GO:0046965 9.43 NR1H4 NR1H2
7 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.28 MIR483 MIR31 MIR29A MIR222 MIR199A1 MIR196A1
8 nuclear receptor activity GO:0004879 9.26 NR1I3 NR1I2 NR1H4 NR1H2

Sources for Biliary Tract Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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