MCID: BLR006
MIFTS: 49

Biliary Tract Disease

Categories: Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Biliary Tract Disease

MalaCards integrated aliases for Biliary Tract Disease:

Name: Biliary Tract Disease 12 15 17
Biliary Tract Diseases 44 72
Biliary Tract Abnormality 29

Classifications:



External Ids:

Disease Ontology 12 DOID:9741
ICD9CM 35 576.9
MeSH 44 D001660
SNOMED-CT 68 5235004
ICD10 33 K83.8 K83.9
UMLS 72 C0005424

Summaries for Biliary Tract Disease

MalaCards based summary : Biliary Tract Disease, also known as biliary tract diseases, is related to cholecystitis and choledocholithiasis, and has symptoms including digestive system symptom An important gene associated with Biliary Tract Disease is NR1H4 (Nuclear Receptor Subfamily 1 Group H Member 4), and among its related pathways/superpathways are Metabolism and Synthesis of bile acids and bile salts. The drugs Fentanyl and Propofol have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and pancreas, and related phenotypes are homeostasis/metabolism and liver/biliary system

Related Diseases for Biliary Tract Disease

Diseases in the Biliary Tract Disease family:

Rare Biliary Tract Disease

Diseases related to Biliary Tract Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 cholecystitis 31.9 GPT ALB ABCB4
2 choledocholithiasis 31.8 GPT ALB ABCB4
3 cholelithiasis 31.5 NR1H4 GPT CYP7A1 ALB ABCB4
4 cholangitis 31.4 GPT GGT1 ALB ABCB4 ABCB11
5 obstructive jaundice 31.3 SLC25A13 GPT GGT1 ALB
6 sclerosing cholangitis 30.9 NR1I2 NR1H4 GGT1 ALB ABCB4 ABCB11
7 viral hepatitis 30.7 GPT GGT1 ALB
8 biliary atresia 30.7 SLC10A1 NR1H4 KRT7 GPT ATP8B1 ALB
9 cholangitis, primary sclerosing 30.6 NR1I2 KRT19 GPT GGT1 ALB ABCB4
10 gastrointestinal system disease 30.5 NR1I2 GGT2 GGT1 ALB
11 bile duct cancer 30.4 PRRT2 KRT7 KRT19 ABCC2
12 liver disease 30.4 SLC25A13 NR1H4 GPT GGT1 ATP8B1 ALB
13 extrahepatic cholestasis 30.0 GPT GGT1 CYP7A1 ABCC3 ABCC2 ABCB4
14 cholestasis 29.1 SLC25A13 SLC10A1 NR1I3 NR1I2 NR1H4 GPT
15 bile duct disease 27.3 SLC25A13 SLC10A1 PRRT2 NR1I2 NR1H4 KRT7
16 genetic biliary tract disease 12.4
17 rare biliary tract disease 12.4
18 autosomal dominant non-syndromic intellectual disability 3 10.8 NR1I3 NR1I2
19 cholestasis, progressive familial intrahepatic, 5 10.8 NR1I3 NR1I2 NR1H4
20 autosomal dominant non-syndromic intellectual disability 2 10.8 NR1I3 NR1I2
21 atp8b1 deficiency 10.8 NR1H4 ATP8B1 ABCB11
22 cholestasis, progressive familial intrahepatic, 4 10.7 ATP8B1 ABCB4 ABCB11
23 cholestasis, progressive familial intrahepatic, 3 10.7 ATP8B1 ABCB4 ABCB11
24 alagille syndrome 1 10.7 ATP8B1 ABCB4 ABCB11
25 cerebrotendinous xanthomatosis 10.7 NR1I2 NR1H4 CYP7A1
26 cholestasis, benign recurrent intrahepatic, 1 10.7 SLC10A1 ATP8B1 ABCB11
27 cyclosporiasis 10.7 GGT2 GGT1
28 intrahepatic bile duct adenoma 10.6 KRT7 KRT19
29 proliferating trichilemmal cyst 10.6 KRT7 KRT19
30 algoneurodystrophy 10.6 GGT2 GGT1
31 anal gland adenocarcinoma 10.6 KRT7 KRT19
32 anus adenocarcinoma 10.6 KRT7 KRT19
33 cholestasis, progressive familial intrahepatic, 2 10.6 NR1H4 ATP8B1 ABCB4 ABCB11
34 cholestasis, progressive familial intrahepatic, 1 10.6 NR1H4 ATP8B1 ABCB4 ABCB11
35 hyperbilirubinemia, rotor type 10.6 ALB ABCC2
36 renal pelvis adenocarcinoma 10.6 KRT7 KRT19
37 periampullary adenoma 10.6 GGT2 GGT1
38 dubin-johnson syndrome 10.6 ABCC4 ABCC3 ABCC2
39 hepatic encephalopathy 10.6 SLC25A13 GPT ALB
40 cutaneous adenocystic carcinoma 10.6 KRT7 KRT19
41 pancreatic cystadenocarcinoma 10.6 GGT2 GGT1
42 kwashiorkor 10.6 GPT ALB
43 ethmoid sinus adenocarcinoma 10.6 GGT2 GGT1
44 ethmoid sinus cancer 10.6 GGT2 GGT1
45 bladder carcinoma in situ 10.5 KRT7 KRT19
46 hepatic coma 10.5 GPT ALB
47 malignant leydig cell tumor 10.5 KRT7 KRT19
48 bile duct adenocarcinoma 10.5 PRRT2 KRT7 KRT19
49 eccrine adenocarcinoma 10.5 KRT7 KRT19
50 corneal abscess 10.5 KRT7 KRT19

Comorbidity relations with Biliary Tract Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Pancreatitis

Graphical network of the top 20 diseases related to Biliary Tract Disease:



Diseases related to Biliary Tract Disease

Symptoms & Phenotypes for Biliary Tract Disease

UMLS symptoms related to Biliary Tract Disease:


digestive system symptom

MGI Mouse Phenotypes related to Biliary Tract Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALB
2 liver/biliary system MP:0005370 9.36 ABCB11 ABCB4 ABCC2 ABCC3 ALB ATP8B1

Drugs & Therapeutics for Biliary Tract Disease

Drugs for Biliary Tract Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Acetaminophen Approved Phase 4 103-90-2 1983
4
Remifentanil Approved Phase 4 132875-61-7 60815
5
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
6 Peripheral Nervous System Agents Phase 4
7 Anesthetics Phase 4
8 Central Nervous System Depressants Phase 4
9 Hypnotics and Sedatives Phase 4
10 Anesthetics, General Phase 4
11 Anesthetics, Intravenous Phase 4
12 Narcotics Phase 4
13 Analgesics Phase 4
14 Analgesics, Opioid Phase 4
15
Trioxsalen Approved Phase 2, Phase 3 3902-71-4 5585
16
Sodium citrate Approved, Investigational Phase 3 68-04-2
17
Tamoxifen Approved Phase 3 10540-29-1 2733526
18
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
19
Octreotide Approved, Investigational Phase 3 83150-76-9 383414 6400441
20
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
21
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
22 Dihematoporphyrin Ether Phase 2, Phase 3
23 Hematoporphyrin Derivative Phase 2, Phase 3
24 Photosensitizing Agents Phase 2, Phase 3
25 Immunologic Factors Phase 3
26 Immunosuppressive Agents Phase 3
27 Gastrointestinal Agents Phase 3
28 Hormones Phase 3
29 Estrogens Phase 3
30 Alkylating Agents Phase 3
31 Selective Estrogen Receptor Modulators Phase 3
32
Liposomal doxorubicin Phase 3 31703
33 Citrate Phase 3
34 Antibiotics, Antitubercular Phase 3
35 Anti-Bacterial Agents Phase 3
36 Estrogen Receptor Modulators Phase 3
37 Hormone Antagonists Phase 3
38 Antineoplastic Agents, Hormonal Phase 3
39 Estrogen Receptor Antagonists Phase 3
40 Topoisomerase Inhibitors Phase 3
41 Antirheumatic Agents Phase 3
42 Estrogen Antagonists Phase 3
43 Antineoplastic Agents, Alkylating Phase 3
44 Bone Density Conservation Agents Phase 3
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
46 Pharmaceutical Solutions Phase 3
47 Liver Extracts Phase 3
48 Hematinics Phase 3
49
Gemcitabine Approved Phase 2 95058-81-4 60750
50
Fluorouracil Approved Phase 2 51-21-8 3385

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 A Clinical Registry to Assess Performance and Clinical Utility of the SpyGlass Direct Visualization System Completed NCT00751998 Phase 4
2 Alfentanil vs Remifentanil in Patient-controlled Sedation During ERCP.A Randomized Double-blind Study Completed NCT01350037 Phase 4 alfentanil;remifentanil
3 A Randomized Controlled Trial Comparing Endoscopic Biliary Radiofrequency Ablation With Photodynamic Therapy for Inoperable Cholangiocarcinoma Unknown status NCT01739465 Phase 2, Phase 3
4 Effect of Saline Irrigation to Decrease Rate of Residual Common Bile Duct Stones Unknown status NCT01425177 Phase 3
5 An Expertise-based Randomized Controlled Trial Comparing Minilaparotomy Cholecystectomy and Laparoscopic Cholecystectomy Completed NCT00370344 Phase 2, Phase 3
6 A Clinical Trial to Evaluate the Benefit of Adding Octreotide (SMS 201-995 PA LAR) to Tamoxifen Alone or to Tamoxifen and Chemotherapy in Patients With Axillary Node-Negative, Estrogen-Receptor-Positive, Primary Invasive Breast Cancer Completed NCT00002967 Phase 3 cyclophosphamide;doxorubicin hydrochloride;octreotide pamoate;tamoxifen citrate
7 MRX-502: Randomized Double-blind Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety of Maralixibat in the Treatment of Subjects With Progressive Familial Intrahepatic Cholestasis (PFIC) - MARCH-PFIC Recruiting NCT03905330 Phase 3 Maralixibat
8 A Multicenter Randomized Controlled Trial to Compare the Efficacy of End-ischemic Dual Hypothermic Oxygenated Perfusion With Standard Static Cold Storage of Liver Grafts Donated After Circulatory Death in Preventing Biliary Complications Recruiting NCT02584283 Phase 3 Glutathione
9 Effect of a Fatty Meal on Cannulation at Endoscopic Retrograde Cholangiopancreatography Completed NCT00124202 Phase 1, Phase 2
10 Prospective Phase II Randomized Trial-Weekly Gemcitabine Plus High-Dose 5-Fluorouracil/ Leucovorin in the Treatment of Advanced or Metastatic Carcinoma of the Biliary Tract Completed NCT00201305 Phase 2 Gemcitabine+5FU+Leucovorin
11 Transvaginal Natural Orifice Translumenal and Endoscopic Surgery (NOTES) Cholecystectomy vs. Laparoscopic Cholecystectomy: Phase I/II Clinical Trial Completed NCT00710502 Phase 1, Phase 2
12 Treatment of Suspected Cholelithiasis With Nitroglycerin: a Randomized, Prospective Double-blind Trial Recruiting NCT01715220 Phase 2 sublingual nitroglycerine
13 A Phase 2, Randomized, Double-Blind Study of HTD1801 vs Ursodeoxycholic Acid (UDCA) in Adolescents With Primary Sclerosing Cholangitis (PSC) Not yet recruiting NCT03678480 Phase 2 HTD1801;Ursodeoxycholic Acid
14 A Phase 2, Randomized, Double Blind, Placebo Controlled, Multiple Center Study to Evaluate the Safety, Tolerability, and Efficacy of Seladelpar Administered for 24 Weeks in Adult Patients With Primary Sclerosing Cholangitis (PSC) Not yet recruiting NCT04024813 Phase 2 Seladelpar;Placebo to match Seladelpar
15 Safety and Efficacy Study of IL-10 (Tenovil TM) in the Prevention of Post-ERCP Acute Pancreatitis (Study P02580)(TERMINATED) Terminated NCT00040131 Phase 2 IL-10
16 A Network on the Quality of ERCP, on the Organization of the Endoscopic Units and on the Training of the Endoscopists in Italy Unknown status NCT02971579
17 Comparison Between Continuous Infusion and Intermittent Bolus Injection of Propofol for Deep Sedation During Endoscopic Retrograde Cholangiopancreatography: a Prospective Randomized Controlled Study Unknown status NCT01900938 Midazolam;Propofol
18 Zhujiang Hospital of the Southern Medical University Unknown status NCT03074708
19 An Evaluation of the Utility of the ExSpiron Respiratory Variation Monitor During Upper GI Endoscopy Unknown status NCT02310230
20 Prospective Evaluation of the Clinical Utility of Endoscopic Retrograde Cholangiopancreatography (ERCP) Guided Cholangiopancreatoscopy With the SpyGlass DS. Completed NCT02524418
21 Clinical Registry of Cholangioscopy Using the SpyGlass™ Direct Visualization System Throughout China Completed NCT02287194
22 A Multicenter Randomized Trial Comparing the Use of Touch and no Touch Guide-wire Techniques for Deep Biliary Cannulation: the TNT Study Completed NCT01954602
23 Endoscopic Treatment of Benign Biliary Strictures and Cystic Duct Leakages With a Novel Biodegradable Polydioxanone Biliary Stent Completed NCT02353286
24 Use of Serum Proteome on the Early Diagnosis of Malignant Biliary-Pancreatic Disease Completed NCT00559598
25 Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method in Patients With High Risk of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Multicenter Randomized Controlled Trial Completed NCT02916199
26 Safety and Efficacy of n-3 Fatty Acid-based Parenteral Nutrition in Patients With Obstructive Jaundice: A Propensity-matched Study Completed NCT03376945 trail cohort;control cohort
27 The Role of Antibiotic Treatment in Patients With Acute Mild Cholecystitis - A Prospective Randomized Controlled Trial Completed NCT00557453 Antibiotic treatment;No antibiotics
28 Sahlgrenska EUS ERCP Study Recruiting NCT03504293
29 Gastrointestinal Microbiomes in Patients of Recurrent Common Bile Duct Stones After Endoscopic Sphincterotomy(EST) Recruiting NCT03102281
30 CO2 Cholangiography as an Alternative to Iodinated Contrast in Endoscopic Retrograde Cholangiopancreatography Recruiting NCT02611453
31 Is Needle Knife Fistulotomy An Effective First Step Strategy For All ERCPs? Recruiting NCT03698266
32 Comparison of Standard Endotracheal Intubation [SEI] and Endoscope Assisted Endotracheal Intubation [EAE] Active, not recruiting NCT03879720
33 Assessment of Cholangio-pancreatoscopy for the Diagnosis and the Treatment of Biliary and Pancreatic Diseases Trial " EASYSPY " Active, not recruiting NCT03190343
34 Endoscopic Ultrasound Guided Rendezvous or Direct Interventions Versus Advanced ERCP Techniques for Biliary Access and Therapy Active, not recruiting NCT01678326
35 COMPLICATIONS OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY- AN INDIAN PERSPECTIVE Active, not recruiting NCT04062617
36 Endo-biliary Laser Excision of Biliary Stenoses: Initial Experience and Feasibility Withdrawn NCT02118493
37 Evaluation of Surgical Risk in Elderly Patients Submitted to Elective Surgery: Comparative Study of Elective Vascular, Digestive and Biliary Surgery Withdrawn NCT00672698

Search NIH Clinical Center for Biliary Tract Disease

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Pinaverium

Cochrane evidence based reviews: biliary tract diseases

Genetic Tests for Biliary Tract Disease

Genetic tests related to Biliary Tract Disease:

# Genetic test Affiliating Genes
1 Biliary Tract Abnormality 29

Anatomical Context for Biliary Tract Disease

MalaCards organs/tissues related to Biliary Tract Disease:

41
Liver, Testes, Pancreas, Heart, Bone, Breast, Kidney

Publications for Biliary Tract Disease

Articles related to Biliary Tract Disease:

(show top 50) (show all 1595)
# Title Authors PMID Year
1
Preoperative endoscopic retrograde cholangio-pancreatography (ERCP) is a risk factor for surgical site infections after laparoscopic cholecystectomy. 38
30473225 2019
2
Activated cholangiocytes release macrophage-polarizing extracellular vesicles bearing the DAMP S100A11. 38
31365294 2019
3
[A consensus statement on the standardized application of antibacterial agents in biliary tract surgery (2019)]. 38
31269607 2019
4
Associations between ambient temperature and hepatobiliary and renal hospitalizations in California, 1999 to 2009. 38
31323396 2019
5
The association between apolipoprotein E and gallstone disease: an updated meta-analysis. 38
31200656 2019
6
Development of a biliary multi-hole self-expandable metallic stent for bile tract diseases: A case report. 38
31236396 2019
7
[The new classifications of biliary tract diseases based on actual anatomy]. 38
31142064 2019
8
Biliary Tract Disease in Girls and Young Women With Rett Syndrome. 38
30664568 2019
9
Prognosis of liver abscess with no identified organism. 38
31151426 2019
10
[Clinical characteristics in patients with hypervirulent Klebsiella pneumoniae infection and its capsular serotypes and multilocus sequence typing]. 38
31060144 2019
11
[Differential diagnoses of biliary tract diseases : Computed tomography and magnetic resonance imaging]. 38
30820619 2019
12
A cohort study of age and sex specific risk of pyogenic liver abscess incidence in patients with type 2 diabetes mellitus. 38
31027123 2019
13
[Percutaneous biliary and gallbladder interventions]. 38
30806733 2019
14
Re-admission patterns in England and the Netherlands: a comparison based on administrative data of all hospitals. 38
30445564 2019
15
Predictors of Clostridioides difficile recurrence across a national cohort of veterans in outpatient, acute, and long-term care settings. 38
31361830 2019
16
Recurrent retroperitoneal abscess after biliary tract surgery in an elderly patient: a minimally invasive nonsurgical approach and its consequences: a case report. 38
30798788 2019
17
How Would You Treat This Patient With Gallstone Pancreatitis?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. 38
30716756 2019
18
Epidemiology of Pediatric Acute Pancreatitis in Taiwan: A Nationwide Population-based Study. 38
30358742 2019
19
Complications of Solid Organ Transplantation: Cardiovascular, Neurologic, Renal, and Gastrointestinal. 38
30447778 2019
20
Efficacy and safety of Yinchen Sini decoction in treating biliary atresia patients after Kasai portoenterostomy: A systematic review and meta-analysis protocol. 38
30633169 2019
21
Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018. 38
30315778 2019
22
Perspective for evaluation of microrna in plasma and bile for differential diagnosis of obstructive biliary tract disease. 38
31398176 2019
23
The microbiota of the bilio-pancreatic system: a cohort, STROBE-compliant study. 38
31354308 2019
24
Gallbladder agenesis with hepatic impairment: a case report. 38
30454006 2018
25
The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer. 38
30451962 2018
26
Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review. 38
30015401 2018
27
Burden of gastrointestinal and liver diseases in India, 1990-2016. 38
30306342 2018
28
Fitz-Hugh-Curtis syndrome in a man positive for Chlamydia trachomatis. 38
29417387 2018
29
Safety and efficacy of n-3 fatty acid-based parenteral nutrition in patients with obstructive jaundice: a propensity-matched study. 38
30006616 2018
30
[Analysis of related factors for hepatic alveolar echinococcosis and gallbladder complications of children in Qinghai Province]. 38
30891975 2018
31
The diagnostic value of five serum tumor markers for patients with cholangiocarcinoma. 38
29438681 2018
32
Outcome of elective cholecystectomy for the treatment of gallbladder disease in dogs. 38
29595398 2018
33
How the biliary tree maintains immune tolerance? 38
28844953 2018
34
Novel ex vivo training model for freehand insertion using a double-bending peroral direct cholangioscope. 38
28688125 2018
35
Metastatic Pancreatic Adenocarcinoma Presenting as a Klatskin Tumor. 38
30568968 2018
36
[Síndrome de Fitz-Hugh-Curtis en un paciente varón anciano. Caso y revisión de la literatura]. 38
30226491 2018
37
Characterization of biofilms in biliary stents and potential factors involved in occlusion. 38
29358888 2018
38
Cholangioscopy in the digital era. 38
30505969 2018
39
Isolation of Extracellular RNA from Bile. 38
29388136 2018
40
Newly Diagnosed Idiopathic Liver Abscess: Colonoscopy Required! 38
29038677 2017
41
Primary Sclerosing Cholangitis: What the Gastroenterologist and Hepatologist Needs to Know. 38
28987259 2017
42
Colonization, resistance to bile, and virulence properties of Escherichia coli strains: Unusual characteristics associated with biliary tract diseases. 38
28867623 2017
43
Concurrent Biliary Disease Increases the Risk for Conversion and Bile Duct Injury in Laparoscopic Cholecystectomy: A Retrospective Analysis at a County Teaching Hospital. 38
29391088 2017
44
Role of endoscopic ultrasound in idiopathic pancreatitis. 38
29097868 2017
45
The Almost-Normal Liver Biopsy: Presentation, Clinical Associations, and Outcome. 38
28614198 2017
46
Biliary Tract and Liver Complications in Polycystic Kidney Disease. 38
28465378 2017
47
The importance of routine bedside biliary ultrasonography in the management of patients admitted to the emergency department with isolated acute epigastric pain 38
29156853 2017
48
[Research advances of relationship between non-alcoholic fatty liver disease and biliary tract diseases]. 38
29056017 2017
49
Acute pancreatitis induced by etoposide-lobaplatin combination chemotherapy used for the treatment of lung cancer: A case report and literature review. 38
28723805 2017
50
Predictors for early readmission in acute pancreatitis (AP) in the United States (US) - A nationwide population based study. 38
28583749 2017

Variations for Biliary Tract Disease

Expression for Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for Biliary Tract Disease

Pathways related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 SLC25A13 SLC10A1 NR1H4 GPT GGT2 GGT1
2
Show member pathways
12.04 SLC10A1 NR1H4 CYP7A1 ALB ABCC3 ABCB11
3 11.93 GGT2 GGT1 ABCC4 ABCC3 ABCC2
4
Show member pathways
11.9 SLC10A1 ABCC2 ABCB4 ABCB11
5
Show member pathways
11.79 ABCC4 ABCC2 ABCB11
6
Show member pathways
11.7 NR1I3 NR1I2 NR1H4
7
Show member pathways
11.62 ABCC4 ABCC3 ABCC2
8 11.62 SLC10A1 NR1H4 CYP7A1 ABCC4 ABCC3 ABCC2
9
Show member pathways
11.51 NR1I3 NR1I2 ABCC2
10 11.18 NR1I3 ABCC3 ABCC2
11 11.14 ABCC4 ABCC3 ABCC2
12 11.1 NR1I3 NR1I2 NR1H4 CYP7A1 ABCC3 ABCC2
13 10.99 ABCC4 ABCC3 ABCC2
14 10.95 GGT2 GGT1
15 10.93 SLC10A1 NR1H4 CYP7A1 ABCB4 ABCB11
16
Show member pathways
10.91 ABCC4 ABCC3 ABCC2
17 10.84 ABCC4 ABCC3 ABCC2
18 10.75 NR1I2 ABCC3
19 10.54 ABCC3 ABCC2
20 10.51 SLC10A1 NR1I3 NR1I2 NR1H4 CYP7A1 ABCC4

GO Terms for Biliary Tract Disease

Cellular components related to Biliary Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 SLC25A13 SLC10A1 ATP8B1 ABCC3 ABCC2 ABCB4
2 extracellular exosome GO:0070062 9.61 KRT7 KRT19 GPT GGTLC3 GGT2 GGT1
3 RNA polymerase II transcription factor complex GO:0090575 9.33 NR1I3 NR1I2 NR1H4
4 intercellular canaliculus GO:0046581 8.8 ABCC2 ABCB4 ABCB11

Biological processes related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.87 SLC25A13 SLC10A1 ABCC4 ABCC3 ABCC2 ABCB4
2 steroid hormone mediated signaling pathway GO:0043401 9.65 NR1I3 NR1I2 NR1H4
3 intracellular receptor signaling pathway GO:0030522 9.61 NR1I3 NR1I2 NR1H4
4 zymogen activation GO:0031638 9.55 GGT2 GGT1
5 bile acid metabolic process GO:0008206 9.54 NR1H4 ATP8B1
6 regulation of immune system process GO:0002682 9.49 GGT2 GGT1
7 regulation of bile acid biosynthetic process GO:0070857 9.46 NR1H4 CYP7A1
8 glutathione catabolic process GO:0006751 9.43 GGTLC3 GGT2 GGT1
9 peptide modification GO:0031179 9.4 GGT2 GGT1
10 drug transmembrane transport GO:0006855 9.37 ATP8B1 ABCC2
11 leukotriene D4 biosynthetic process GO:1901750 9.33 GGTLC3 GGT2 GGT1
12 glutamate metabolic process GO:0006536 9.26 GGT1
13 xenobiotic transport GO:0042908 9.22 NR1I2
14 cysteine biosynthetic process GO:0019344 9.21 GGT1
15 canalicular bile acid transport GO:0015722 9.13 ABCC3 ABCC2 ABCB11
16 bile acid and bile salt transport GO:0015721 9.02 SLC10A1 NR1H4 ATP8B1 ABCC3 ABCB11

Molecular functions related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transporter activity GO:0022857 9.67 SLC25A13 ABCC3 ABCC2
2 ATPase activity GO:0016887 9.65 ABCC4 ABCC3 ABCC2 ABCB4 ABCB11
3 transcription regulatory region sequence-specific DNA binding GO:0000976 9.63 NR1I3 NR1I2 NR1H4
4 nuclear receptor transcription coactivator activity GO:0030374 9.61 NR1I3 NR1I2 NR1H4
5 steroid hormone receptor activity GO:0003707 9.58 NR1I3 NR1I2 NR1H4
6 nuclear receptor activity GO:0004879 9.5 NR1I3 NR1I2 NR1H4
7 organic anion transmembrane transporter activity GO:0008514 9.48 ABCC3 ABCC2
8 peptidyltransferase activity GO:0000048 9.37 GGT2 GGT1
9 bile acid-exporting ATPase activity GO:0015432 9.16 ABCC3 ABCB11
10 glutathione hydrolase activity GO:0036374 9.13 GGTLC3 GGT2 GGT1
11 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.02 ABCC4 ABCC3 ABCC2 ABCB4 ABCB11

Sources for Biliary Tract Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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