MCID: BLR006
MIFTS: 54

Biliary Tract Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Biliary Tract Disease

MalaCards integrated aliases for Biliary Tract Disease:

Name: Biliary Tract Disease 12 15
Biliary Tract Diseases 44 73
Biliary Tract Abnormality 29

Classifications:



External Ids:

Disease Ontology 12 DOID:9741
ICD10 33 K83.9 K83.8
ICD9CM 35 576.9
MeSH 44 D001660
UMLS 73 C0005424

Summaries for Biliary Tract Disease

MalaCards based summary : Biliary Tract Disease, also known as biliary tract diseases, is related to cholecystitis and obstructive jaundice, and has symptoms including digestive system symptom An important gene associated with Biliary Tract Disease is NR1H4 (Nuclear Receptor Subfamily 1 Group H Member 4), and among its related pathways/superpathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Lidocaine and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and pancreas, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Biliary Tract Disease

Diseases related to Biliary Tract Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 cholecystitis 30.6 ABCB4 ALB CCK
2 obstructive jaundice 30.2 ALB GGT1 SLC25A13
3 cholangitis, primary sclerosing 30.0 ABCB4 GGT1 NR1I2
4 cholangitis 29.9 ABCB11 ABCB4 ALB GGT1
5 cholelithiasis 29.9 ABCB4 ALB CCK CYP7A1 NR1H4
6 sclerosing cholangitis 29.7 ABCB11 ABCB4 ALB GGT1 NR1I2
7 atp8b1 deficiency 10.7 ABCB11 ATP8B1 NR1H4
8 cholestasis, benign recurrent intrahepatic, 1 10.7 ABCB11 ATP8B1
9 cholestasis, progressive familial intrahepatic, 2 10.7 ABCB11 ABCB4 ATP8B1
10 cholestasis, progressive familial intrahepatic, 3 10.7 ABCB11 ABCB4 ATP8B1
11 xanthomatosis 10.6 CYP7A1 NR1H4 NR1I2
12 cerebrotendinous xanthomatosis 10.6 CYP7A1 NR1H4 NR1I2
13 dubin-johnson syndrome 10.5 ABCC2 ABCC3 ABCC4
14 paralytic ileus 10.5 ALB CCK
15 hyperbilirubinemia, rotor type 10.5 ABCC2 ALB
16 cyclosporiasis 10.4 GGT1 GGT2
17 autoimmune disease of urogenital tract 10.4 ABCB4 ALB GGT2
18 algoneurodystrophy 10.3 GGT1 GGT2
19 periampullary adenoma 10.3 GGT1 GGT2
20 pancreatitis 10.2
21 hepatic tuberculosis 10.2 ALB GGT1 GGT2
22 ethmoid sinus cancer 10.2 GGT1 GGT2
23 bilirubin metabolic disorder 10.1 ABCC2 ALB GGT1 NR1I3
24 common bile duct disease 10.1 CCK GGT2
25 ethmoid sinus adenocarcinoma 10.1 GGT1 GGT2
26 cholecystolithiasis 10.0 ABCB4 CCK
27 biliary atresia 10.0 ALB ATP8B1 NR1H4 SLC10A1 SLC10A2
28 aging 10.0
29 hepatitis 9.9
30 duodenitis 9.9
31 primary biliary cirrhosis 9.9 ABCB4 ABCC3 ALB GGT1 NR1H4
32 extrahepatic cholestasis 9.8 ABCB4 ABCC2 ABCC3 CYP7A1 GGT1
33 sickle cell anemia 9.8
34 cholestasis, progressive familial intrahepatic, 1 9.7 ABCB11 ABCB4 ATP8B1 GGT1 NR1H4 SLC10A2
35 duodenal atresia 9.7
36 down syndrome 9.7
37 cystic fibrosis 9.7
38 body mass index quantitative trait locus 1 9.7
39 beta-thalassemia 9.7
40 thalassemia 9.7
41 portal hypertension 9.7
42 chlamydia 9.7
43 bacteriuria 9.7
44 gastroenteritis 9.7
45 cystadenoma 9.7
46 acute pancreatitis 9.7
47 duodenal obstruction 9.7
48 pancreatic cystadenoma 9.7
49 eosinophilic gastroenteritis 9.7
50 klatskin's tumor 9.7

Comorbidity relations with Biliary Tract Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Pancreatitis

Graphical network of the top 20 diseases related to Biliary Tract Disease:



Diseases related to Biliary Tract Disease

Symptoms & Phenotypes for Biliary Tract Disease

UMLS symptoms related to Biliary Tract Disease:


digestive system symptom

GenomeRNAi Phenotypes related to Biliary Tract Disease according to GeneCards Suite gene sharing:

26 (show all 37)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.99 SLC51B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.99 NR1I2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.99 ABCC3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.99 SLC51B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.99 SLC51B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.99 NR1I2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.99 GGT2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.99 ABCC3 GGT1 GGT2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.99 GGT2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.99 NR1I2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.99 NR1I2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.99 GGT2 ABCB11 ABCC3 GGT1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.99 ABCC3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.99 SLC10A2 SLC51B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.99 SLC51B
16 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.99 NR1I2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.99 GGT1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.99 NR1I2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.99 ABCC3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.99 ABCC3 SLC51B
21 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.99 SLC10A2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.99 NR1I2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.99 SLC51B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.99 ABCC3
25 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.99 ABCB11
26 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.99 GGT2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.99 SLC51B
28 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.99 SLC10A2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.99 ABCB11
30 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.99 SLC10A2
31 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.99 GGT2 GGT1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.99 SLC51B
33 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.99 SLC10A2
34 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.99 ABCB11
35 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.99 ABCB11
36 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.99 NR1I2 SLC10A2 SLC51B
37 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.99 SLC51B

MGI Mouse Phenotypes related to Biliary Tract Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.86 CYP7A1 CYP8B1 GGT1 NR1H4 NR1I2 ABCB11
2 digestive/alimentary MP:0005381 9.7 CYP7A1 CYP8B1 NR1H4 ABCB4 SLC10A2 ABCC4
3 liver/biliary system MP:0005370 9.44 CYP8B1 NR1H4 NR1I2 ABCB11 NR1I3 ABCB4

Drugs & Therapeutics for Biliary Tract Disease

Drugs for Biliary Tract Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 505)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
2
Etomidate Approved Phase 4 33125-97-2 36339 667484
3
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
4
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
5
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
6
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
7
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 128-13-2 31401
8
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
9
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
10
Ketamine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 6740-88-1 3821
11
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
12
Isoflurane Approved, Vet_approved Phase 4,Not Applicable 26675-46-7 3763
13
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
14
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
15
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
16
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613
17
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 2078-54-8 4943
18
Vancomycin Approved Phase 4,Phase 3,Phase 1,Not Applicable 1404-90-6 441141 14969
19
Benzocaine Approved, Investigational Phase 4,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
20
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
21
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 53608-75-6
22 Pinaverium Approved Phase 4,Not Applicable 59995-65-2
23 Nefopam Approved, Investigational Phase 4 13669-70-0
24
Ceftriaxone Approved Phase 4,Phase 2 73384-59-5 5479530 5361919
25
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
26
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
27
chenodeoxycholic acid Approved Phase 4,Phase 3,Phase 2,Early Phase 1 474-25-9 10133
28
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
29
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
30
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
31
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
32
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
33
Minocycline Approved, Investigational Phase 4,Phase 1 10118-90-8 5281021
34
Ephedrine Approved Phase 4,Not Applicable 299-42-3 9294
35
Pseudoephedrine Approved Phase 4,Not Applicable 90-82-4 7028
36
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
37
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
38
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
39
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 443-48-1 4173
40
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
41
Tigecycline Approved Phase 4,Phase 1 220620-09-7 5282044
42
Acetaminophen Approved Phase 4 103-90-2 1983
43
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
44
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
45
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
46
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
47
Tauroursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Not Applicable 14605-22-2 12443252
48
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
49
Ondansetron Approved Phase 4 99614-02-5 4595
50
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345

Interventional clinical trials:

(show top 50) (show all 997)
# Name Status NCT ID Phase Drugs
1 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Unknown status NCT02605213 Phase 4 Vancomycin;Placebo
2 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
3 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Unknown status NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
4 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
5 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
6 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
7 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
8 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
9 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
10 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
11 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
12 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
13 Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
14 Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery Unknown status NCT02174575 Phase 4 Sevoflurane;Desflurane
15 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline;Ademethionine
16 Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis Unknown status NCT01998620 Phase 4 Ademetionine 2;Ademetionine 1;Ademetionine 3
17 Additional Effects of Perioperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy Unknown status NCT01969110 Phase 4
18 Effects of Preoperative Immunonutrition in Patients Undergoing Hepatectomy Unknown status NCT01256047 Phase 4
19 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
20 Spy II Clinical Registry Completed NCT00751998 Phase 4
21 Alfentanil Versus Remifentanil in Patient-controlled Sedation During Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT01350037 Phase 4 alfentanil;remifentanil
22 Effect IV Ibuprofen and Inflammatory Responses Completed NCT01938040 Phase 4 ibuprofen
23 The Usefulness of Endoscopic Ultrasound-guided Biliary Drainage With a Newly Designed Hybrid Metallic Stent Completed NCT01862198 Phase 4
24 A Study Comparing the Use of Deep or Standard Neuromuscular Blockade in Combination With Low or Standard Insufflation Pressures in Participants Undergoing Laparoscopic Cholecystectomy (P07982) Completed NCT01728584 Phase 4 Rocuronium;Sugammadex
25 Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. Completed NCT01709422 Phase 4 Propofol;Midazolam;Meperidine
26 Cocktail Sedation Containing Propofol Versus Conventional Sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT01540084 Phase 4 propofol
27 Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy Completed NCT01833819 Phase 4 Dexmedetomidine and lidocaine;Remifentanil
28 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
29 Vitamin C Efficacy in Reducing Post Operative Pain Completed NCT01322061 Phase 4 Ascorbic Acid
30 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
31 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
32 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
33 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
34 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
35 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
36 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
37 Clinical Study About the Role of COX-2 Inhibitor in Liver Cirrhosis With Biliary Atresia Completed NCT02298218 Phase 4 Meloxicam
38 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
39 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
40 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
41 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
42 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
43 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4 Rowachol;Placebo
44 Radiofrequency Ablation for Malignant Biliary Obstruction Completed NCT01758341 Phase 4
45 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
46 A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
47 Preventing Cholestasis Using SMOFLipid® Completed NCT01585935 Phase 4 SMOFLIPID;INTRALIPID
48 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
49 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
50 Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis Completed NCT01510860 Phase 4 UDCA (Ursodeoxycholic acid);UDCA (Ursodeoxycholic acid)

Search NIH Clinical Center for Biliary Tract Disease

Cochrane evidence based reviews: biliary tract diseases

Genetic Tests for Biliary Tract Disease

Genetic tests related to Biliary Tract Disease:

# Genetic test Affiliating Genes
1 Biliary Tract Abnormality 29

Anatomical Context for Biliary Tract Disease

MalaCards organs/tissues related to Biliary Tract Disease:

41
Liver, Lung, Pancreas, Testes, T Cells, Bone, Nk Cells

Publications for Biliary Tract Disease

Articles related to Biliary Tract Disease:

(show top 50) (show all 280)
# Title Authors Year
1
Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures: Retrospective Cohort Analysis of a US Population. ( 26706861 )
2016
2
Single-incision laparoscopic surgery for biliary tract disease. ( 26811621 )
2016
3
Risk and Surveillance of Cancers in Primary Biliary Tract Disease. ( 27413366 )
2016
4
Primary Sclerosing Cholangitis as a Premalignant Biliary Tract Disease: Surveillance and Management. ( 26051390 )
2015
5
Body mass index and biliary tract disease: a systematic review and meta-analysis of prospective studies. ( 24721739 )
2014
6
Ketamine abuse, biliary tract disease, and secondary sclerosing cholangitis. ( 23695896 )
2013
7
Impact of an acute care surgery model with a dedicated daytime operating room on outcomes and timeliness of care in patients with biliary tract disease. ( 23756774 )
2013
8
Cholangioscopy using a new type of cholangioscope for the diagnosis of biliary tract disease: a case series. ( 22814962 )
2012
9
Prognostic relevance of circulating CK19 mRNA in advanced malignant biliary tract diseases. ( 22253524 )
2012
10
Role of intraoperative flexible Choledochoscopy in calculous biliary tract disease. ( 22828544 )
2012
11
Transgastric endoscopic retrograde cholangiopancreatography for the management of biliary tract disease after Roux-en-Y gastric bypass treatment for obesity. ( 22460551 )
2012
12
Endoscopic diagnosis of biliary tract disease. ( 22343346 )
2012
13
A stunning year for advances in biliary tract disease. ( 21423005 )
2011
14
Imaging of biliary tract disease. ( 21940525 )
2011
15
Peroral cholangioscopy for diagnosis and therapy of biliary tract disease using an ultra-slim gastroscope. ( 21823068 )
2011
16
Management of biliary tract disease during pregnancy. ( 20193902 )
2010
17
Endoscopic retrograde cholangiopancreatography in pancreatic and biliary tract disease in Korean children. ( 20101777 )
2010
18
Vascular factors, angiogenesis and biliary tract disease. ( 20061944 )
2010
19
The role of international classification of diseases in assessment of patients with biliary tract disease. ( 19745312 )
2009
20
Farnesoid X receptor agonists in biliary tract disease. ( 19300246 )
2009
21
Minimally invasive management of acute biliary tract disease during pregnancy. ( 19606252 )
2009
22
Chlamydia infection as risk factor for pediatric biliary tract disease. ( 18334886 )
2008
23
Double-balloon enteroscopy application in biliary tract disease-its therapeutic and diagnostic functions. ( 18561917 )
2008
24
Management of biliary tract disease during pregnancy: a decision analysis. ( 17713817 )
2008
25
Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathy. ( 17063088 )
2006
26
Biliary tract disease as a risk factor for Plesiomonas shigelloides bacteraemia: a nine-year experience in a Hong Kong hospital and review of the literature. ( 15782626 )
2005
27
Bacteriuria in patients with gallbladder and biliary tract diseases. ( 16295397 )
2004
28
Medical versus surgical management of biliary tract disease in pregnancy. ( 15619495 )
2004
29
Helicobacter pylori and the risk of benign and malignant biliary tract disease. ( 12879485 )
2003
30
Gallbladder and biliary tract disease in the intensive care unit. ( 12610852 )
2003
31
Prenatal diagnosis of liver and biliary tract disease. ( 15001123 )
2003
32
Biliary tract disease: a rare manifestation of eosinophilic gastroenteritis. ( 12757181 )
2003
33
Lymphoplasmacytic chronic cholecystitis and biliary tract disease in patients with lymphoplasmacytic sclerosing pancreatitis. ( 12657928 )
2003
34
Diffuse lymphoplasmacytic chronic cholecystitis is highly specific for extrahepatic biliary tract disease but does not distinguish between primary and secondary sclerosing cholangiopathy. ( 14508392 )
2003
35
MR and ultrasound in screening of patients with suspected biliary tract disease. ( 11972468 )
2002
36
Helicobacter pylori and the risk of benign and malignant biliary tract disease. ( 12404289 )
2002
37
The role of microorganisms in biliary tract disease. ( 11900683 )
2002
38
Imaging the spectrum of biliary tract disease. ( 12479714 )
2002
39
Bacteriology and antimicrobial susceptibility in biliary tract disease: an audit of 10-year's experience. ( 12197428 )
2002
40
Endoscopic management of biliary tract disease. ( 17031203 )
2001
41
Trypsinogen-1, -2 and tumour-associated trypsin-inhibitor in bile and biliary tract tissues from patients with biliary tract diseases and pancreatic carcinomas. ( 11347977 )
2001
42
Biliary tract disease and acute non-A-E hepatitis in Hong Kong: prospective study. ( 11514745 )
2001
43
Endoscopic therapy for biliary tract disease before orthotopic liver transplantation. ( 11175974 )
2001
44
Role of operative flexible choledochoscopy in calculous biliary tract disease. ( 10881633 )
2000
45
Management of biliary tract disease in heart and lung transplant patients. ( 11015098 )
2000
46
[The pathogenesis of biliary stone formation and its prevention in biliary tract diseases]. ( 10222553 )
1999
47
Recommendations for management of liver and biliary tract disease in cystic fibrosis. Cystic Fibrosis Foundation Hepatobiliary Disease Consensus Group. ( 9934970 )
1999
48
Experience with percutaneous transhepatic cholangioscopy (PTCS) in the management of biliary tract disease. ( 10594265 )
1999
49
Endoscopic and surgical integration in the approach to biliary tract disease. ( 10192603 )
1999
50
The use of magnetic resonance cholangiopancreatography in the management of biliary tract disease in pregnancy. ( 15512428 )
1999

Variations for Biliary Tract Disease

Expression for Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for Biliary Tract Disease

Pathways related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 ABCB11 ABCB4 ABCC3 ALB CYP7A1 CYP8B1
2
Show member pathways
13.26 ABCB4 ABCC2 ABCC3 ABCC4 ALB ATP8B1
3
Show member pathways
12.15 ABCB11 ABCC3 ALB CYP7A1 CYP8B1 NR1H4
4 11.99 ABCC2 ABCC3 ABCC4 GGT1 GGT2
5
Show member pathways
11.9 ABCB11 ABCB4 ABCC2 SLC10A1 SLCO1A2
6 11.75 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 CYP7A1
7
Show member pathways
11.71 NR1H4 NR1I2 NR1I3
8
Show member pathways
11.71 ABCB11 ABCC2 ABCC4 SLCO1A2
9
Show member pathways
11.64 ABCC2 ABCC3 ABCC4
10
Show member pathways
11.47 ABCC2 NR1I2 NR1I3
11 11.21 ABCC2 ABCC3 NR1I3
12 11.18 ABCC2 ABCC3 ABCC4
13 11.08 ABCB11 ABCB4 CYP7A1 CYP8B1 NR1H4 SLC10A1
14 11.05 ABCC2 ABCC3 ABCC4
15 10.97 GGT1 GGT2
16
Show member pathways
10.97 ABCC2 ABCC3 ABCC4 SLCO1A2
17 10.89 ABCC2 ABCC3 ABCC4
18 10.89 ABCB11 ABCC2 ABCC3 ABCC4 CYP7A1 NR1H4
19 10.82 ABCB11 ABCB4 ABCC2 ABCC3 CYP7A1 CYP8B1
20 10.77 ABCC3 NR1I2
21 10.7 ABCC2 NR1I2
22 10.56 ABCC2 ABCC3

GO Terms for Biliary Tract Disease

Cellular components related to Biliary Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.71 ABCB4 ABCC2 ATP8B1 SLC10A2
2 integral component of plasma membrane GO:0005887 9.65 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1
3 basolateral plasma membrane GO:0016323 9.56 ABCC3 ABCC4 SLC10A1 SLC51B
4 RNA polymerase II transcription factor complex GO:0090575 9.5 NR1H4 NR1I2 NR1I3
5 brush border membrane GO:0031526 9.33 ABCB4 ABCC2 ATP8B1
6 intercellular canaliculus GO:0046581 8.8 ABCB11 ABCB4 ABCC2
7 integral component of membrane GO:0016021 10.18 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1

Biological processes related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.83 ABCC2 NR1H4 NR1I2 NR1I3
2 steroid hormone mediated signaling pathway GO:0043401 9.76 NR1H4 NR1I2 NR1I3
3 cholesterol homeostasis GO:0042632 9.73 CYP7A1 NR1H4 NR1I2 NR1I3
4 intracellular receptor signaling pathway GO:0030522 9.72 NR1H4 NR1I2 NR1I3
5 response to lipid GO:0033993 9.67 NR1H4 NR1I2 NR1I3
6 bile acid biosynthetic process GO:0006699 9.65 ABCB11 CYP7A1 CYP8B1
7 transmembrane transport GO:0055085 9.65 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 SLC10A1
8 phospholipid translocation GO:0045332 9.63 ABCB4 ATP8B1
9 zymogen activation GO:0031638 9.62 GGT1 GGT2
10 lipid homeostasis GO:0055088 9.62 ABCB4 NR1H4 NR1I2 NR1I3
11 response to glucagon GO:0033762 9.61 ABCB4 ABCC2
12 bile acid metabolic process GO:0008206 9.61 ATP8B1 NR1H4
13 glutathione catabolic process GO:0006751 9.6 GGT1 GGT2
14 leukotriene D4 biosynthetic process GO:1901750 9.59 GGT1 GGT2
15 drug export GO:0046618 9.58 ABCB4 NR1I2
16 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.58 ABCC2 ABCC3 ABCC4
17 bile acid secretion GO:0032782 9.57 ABCB4 SLC51B
18 response to antineoplastic agent GO:0097327 9.56 ABCB4 ABCC2
19 drug transmembrane transport GO:0006855 9.56 ABCB4 ABCC2 ABCC3 ATP8B1
20 regulation of bile acid biosynthetic process GO:0070857 9.54 CYP7A1 NR1H4
21 xenobiotic transport GO:0042908 9.54 ABCB4 ABCC3 NR1I2
22 aromatic compound biosynthetic process GO:0019438 9.51 NR1I2 NR1I3
23 heterocycle biosynthetic process GO:0018130 9.46 NR1I2 NR1I3
24 canalicular bile acid transport GO:0015722 9.33 ABCB11 ABCC2 ABCC3
25 bile acid and bile salt transport GO:0015721 9.28 ABCB11 ABCC3 ALB ATP8B1 NR1H4 SLC10A1
26 lipid metabolic process GO:0006629 10.02 ABCB4 CYP7A1 NR1H4 NR1I2 NR1I3

Molecular functions related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.88 ALB NR1H4 NR1I2 NR1I3
2 transmembrane transporter activity GO:0022857 9.8 ABCC2 ABCC3 SLC25A13 SLC51B
3 ATPase activity GO:0016887 9.8 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4
4 transcription regulatory region sequence-specific DNA binding GO:0000976 9.75 NR1H4 NR1I2 NR1I3
5 ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 9.73 NR1H4 NR1I2 NR1I3
6 steroid hormone receptor activity GO:0003707 9.71 NR1H4 NR1I2 NR1I3
7 nuclear receptor activity GO:0004879 9.65 NR1H4 NR1I2 NR1I3
8 transcription factor activity, RNA polymerase II transcription factor binding GO:0001076 9.63 NR1H4 NR1I2 NR1I3
9 organic anion transmembrane transporter activity GO:0008514 9.61 ABCC2 ABCC3 SLCO1A2
10 glutathione hydrolase activity GO:0036374 9.57 GGT1 GGT2
11 xenobiotic transmembrane transporting ATPase activity GO:0008559 9.55 ABCB4 ABCC3
12 bile acid:sodium symporter activity GO:0008508 9.52 SLC10A1 SLC10A2
13 organic acid transmembrane transporter activity GO:0005342 9.51 SLC10A1 SLC10A2
14 transcription factor activity, direct ligand regulated sequence-specific DNA binding GO:0098531 9.5 NR1H4 NR1I2 NR1I3
15 bile acid transmembrane transporter activity GO:0015125 9.43 SLC10A1 SLC51B SLCO1A2
16 bile acid-exporting ATPase activity GO:0015432 9.37 ABCB11 ABCC3
17 ATPase-coupled anion transmembrane transporter activity GO:0043225 9.33 ABCC2 ABCC3 ABCC4
18 thyroid hormone receptor activity GO:0004887 9.13