MCID: BLR007
MIFTS: 53

Biliary Tract Neoplasm

Categories: Rare diseases, Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Biliary Tract Neoplasm

MalaCards integrated aliases for Biliary Tract Neoplasm:

Name: Biliary Tract Neoplasm 12 29 15 73
Biliary Tract Cancer 76 53 55 73
Carcinoma of Extrahepatic Bile Duct 12 73
Extrahepatic Bile Duct Carcinoma 12 15
Extrahepatic Bile Duct Neoplasm 12 73
Malignant Tumor of Extrahepatic Bile Duct 73
Neoplasm of Extrahepatic Bile Ducts 12
Tumor of the Extrahepatic Bile Duct 12
Bile Duct Extrahepatic Carcinoma 55
Extrahepatic Bile Duct Cancer 12

Classifications:



Summaries for Biliary Tract Neoplasm

Disease Ontology : 12 A hepatobiliary benign neoplasm located in the biliary tract.

MalaCards based summary : Biliary Tract Neoplasm, also known as biliary tract cancer, is related to gallbladder adenoma and bile duct carcinoma. An important gene associated with Biliary Tract Neoplasm is MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Metabolism of proteins and Apoptosis Modulation and Signaling. The drugs Desflurane and Isoflurane have been mentioned in the context of this disorder. Affiliated tissues include the biliary tract, liver and lung, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Cholangiocarcinoma, also known as bile duct cancer, is a form of cancer that is composed of mutated... more...

Related Diseases for Biliary Tract Neoplasm

Diseases related to Biliary Tract Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 254)
# Related Disease Score Top Affiliating Genes
1 gallbladder adenoma 31.8 CDKN2A HRAS
2 bile duct carcinoma 30.5 CDX2 KRT7 MUC1 MUC2 MUC4 TP53
3 biliary papillomatosis 27.5 CDX2 HRAS KRAS KRT7 MUC1 MUC2
4 adenocarcinoma 26.5 CDKN2A HRAS KRAS MUC1 MUC4 SMAD4
5 cholangiocarcinoma 24.2 CDKN2A CDX2 HRAS KRAS KRT7 MUC1
6 extrahepatic bile duct adenocarcinoma 11.3
7 klatskin's tumor 11.3
8 extrahepatic bile duct small cell adenocarcinoma 11.3
9 extrahepatic bile duct adenoma 11.3
10 cap polyposis 10.8 MUC2 MUC4
11 pancreatic intraductal papillary-mucinous neoplasm 10.7 MUC1 MUC2
12 tumor of exocrine pancreas 10.7 MUC1 MUC2
13 tn polyagglutination syndrome 10.7 MUC1 MUC2
14 malignant peritoneal mesothelioma 10.6 CDKN2A MUC1
15 mucinous intrahepatic cholangiocarcinoma 10.6 CDX2 MUC2
16 brain stem astrocytic neoplasm 10.6 CDKN2A TP53
17 endometrial mucinous adenocarcinoma 10.6 CDKN2A MUC1
18 cholangiolocellular carcinoma 10.6 CDKN2A MUC1
19 keratinizing squamous cell carcinoma 10.6 CDKN2A TP53
20 pleomorphic liposarcoma 10.5 CDKN2A MUC1
21 ischemic fasciitis 10.5 CDKN2A MUC1
22 bartholin's gland benign neoplasm 10.5 CDKN2A TP53
23 vulva squamous cell carcinoma 10.5 CDKN2A TP53
24 chronic cholangitis 10.5 CDX2 MUC2
25 filamentary keratitis 10.5 MUC1 MUC4
26 thyroid lymphoma 10.5 CDKN2A TP53
27 inverted transitional papilloma 10.5 CDKN2A KRT7
28 bone squamous cell carcinoma 10.5 CDKN2A TP53
29 scrotal carcinoma 10.5 CDKN2A TP53
30 anal squamous cell carcinoma 10.5 CDKN2A TP53
31 gastric adenosquamous carcinoma 10.5 CDKN2A TP53
32 solid adenocarcinoma with mucin production 10.5 KRT7 MUC1
33 oral leukoplakia 10.5 CDKN2A TP53
34 anogenital venereal wart 10.5 CDKN2A TP53
35 megaesophagus 10.5 CDKN2A TP53
36 endocervical carcinoma 10.5 CDKN2A KRT7
37 chordoid glioma 10.5 MUC1 TP53
38 vulval paget's disease 10.5 CDKN2A KRT7
39 adenoid basal cell carcinoma 10.5 CDKN2A KRT7
40 cervix uteri carcinoma in situ 10.5 CDKN2A TP53
41 endosalpingiosis 10.4 KRT7 MUC1
42 schneiderian carcinoma 10.4 CDKN2A TP53
43 parachordoma 10.4 KRT7 MUC1
44 middle ear adenoma 10.4 KRT7 MUC1
45 esophagus adenocarcinoma 10.4 SMAD4 TP53
46 malignant mixed mullerian tumor 10.4 KRT7 MUC1
47 nodular hidradenoma 10.4 KRT7 MUC1
48 limbal stem cell deficiency 10.4 MUC1 MUC4
49 apocrine adenocarcinoma 10.4 KRT7 MUC1
50 monophasic synovial sarcoma 10.4 KRT7 MUC1

Comorbidity relations with Biliary Tract Neoplasm via Phenotypic Disease Network (PDN):


Acute Pancreatitis Cholangitis
Cholestasis Deficiency Anemia
Intrahepatic Gall Duct Cancer Pancreatic Cancer
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Biliary Tract Neoplasm:



Diseases related to Biliary Tract Neoplasm

Symptoms & Phenotypes for Biliary Tract Neoplasm

GenomeRNAi Phenotypes related to Biliary Tract Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 HRAS KRAS MUC1
2 Decreased viability GR00106-A-0 9.47 KRAS
3 Decreased viability GR00221-A-1 9.47 HRAS KRAS
4 Decreased viability GR00221-A-2 9.47 HRAS KRAS
5 Decreased viability GR00221-A-3 9.47 HRAS
6 Decreased viability GR00301-A 9.47 KRAS
7 Decreased viability GR00381-A-1 9.47 KRAS
8 Decreased viability GR00402-S-2 9.47 HRAS KRAS MUC1

MGI Mouse Phenotypes related to Biliary Tract Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 MUC2 CDKN2A SMAD4 CDX2 TP53 HRAS
2 digestive/alimentary MP:0005381 9.87 MUC2 CDKN2A SMAD4 CDX2 TP53 HRAS
3 endocrine/exocrine gland MP:0005379 9.8 MUC2 CDKN2A SMAD4 CDX2 TP53 HRAS
4 homeostasis/metabolism MP:0005376 9.76 KRT7 MUC2 CDKN2A SMAD4 CDX2 TP53
5 neoplasm MP:0002006 9.5 MUC2 CDKN2A SMAD4 CDX2 TP53 HRAS
6 skeleton MP:0005390 9.1 KRAS CDKN2A SMAD4 CDX2 TP53 HRAS

Drugs & Therapeutics for Biliary Tract Neoplasm

Drugs for Biliary Tract Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 204)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desflurane Approved Phase 4 57041-67-5 42113
2
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
3
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
4
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 53608-75-6
5
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
6 Anesthetics Phase 4
7 Anesthetics, General Phase 4
8 Anesthetics, Inhalation Phase 4
9 Central Nervous System Depressants Phase 4,Not Applicable
10 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Platelet Aggregation Inhibitors Phase 4
12 Analgesics Phase 4,Phase 1
13 Analgesics, Non-Narcotic Phase 4,Phase 1
14 pancreatin Phase 4,Phase 2,Phase 1,Not Applicable
15 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Gastrointestinal Agents Phase 4,Phase 2,Not Applicable
17 Anti-Inflammatory Agents Phase 4
18 Anti-Inflammatory Agents, Non-Steroidal Phase 4
19 Antirheumatic Agents Phase 4
20 Cyclooxygenase 2 Inhibitors Phase 4
21 Cyclooxygenase Inhibitors Phase 4
22 arginine Nutraceutical Phase 4
23 Omega 3 Fatty Acid Nutraceutical Phase 4
24
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 15663-27-1 84093 441203 2767
25
Gemcitabine Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 95058-81-4 60750
26
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
27
Capecitabine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 154361-50-9 60953
28
Fluorouracil Approved Phase 3,Phase 2,Phase 1,Not Applicable 51-21-8 3385
29
Irinotecan Approved, Investigational Phase 2, Phase 3,Phase 1 97682-44-5, 100286-90-6 60838
30
Levoleucovorin Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 68538-85-2
31
Epirubicin Approved Phase 3,Phase 1,Phase 2 56420-45-2 41867
32
Somatostatin Approved, Investigational Phase 3 38916-34-6, 51110-01-1 53481605
33
Trioxsalen Approved Phase 3,Phase 2 3902-71-4 5585
34
Melphalan Approved Phase 2, Phase 3 148-82-3 4053 460612
35
Tegafur Approved, Investigational Phase 3,Phase 2,Phase 1 17902-23-7 5386
36
Citalopram Approved Phase 3 59729-33-8 2771
37
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
38
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 59-30-3 6037
39
Cediranib Investigational Phase 2, Phase 3 288383-20-0 9933475
40 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
41 Antimetabolites Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
42 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
43 Antiviral Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
44 Immunosuppressive Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
45 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable
46 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Not Applicable
47 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
48 Dermatologic Agents Phase 3,Phase 2,Phase 1,Not Applicable
49 Photosensitizing Agents Phase 3,Phase 2,Phase 1,Not Applicable
50 Calcium, Dietary Phase 2, Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 318)
# Name Status NCT ID Phase Drugs
1 Effects of Preoperative Immunonutrition in Patients Undergoing Hepatectomy Unknown status NCT01256047 Phase 4
2 Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery Unknown status NCT02174575 Phase 4 Sevoflurane;Desflurane
3 Additional Effects of Perioperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy Unknown status NCT01969110 Phase 4
4 Radiofrequency Ablation for Malignant Biliary Obstruction Completed NCT01758341 Phase 4
5 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4
6 RCT Steel (Wallstent®) vs Nitinol (Wallflex®) Bile Duct Stent for Palliation of Malignant Obstruction Completed NCT00980889 Phase 4
7 Effects of Preoperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy Completed NCT01256034 Phase 4
8 Comparing Covered Self-expandable Metallic Stent (SEMS) Above/Across the Sphincter of Oddi Completed NCT01041612 Phase 4
9 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
10 Cyclooxygenase-2 Inhibitor for Adjuvant Anticancer Effect in Patients With Biliary-pancreas Cancer Enrolling by invitation NCT01111591 Phase 4 Cox2 inhibitor (Celecoxib)
11 The Effect of Individualized Precision Therapy Programs in Patients With BTC Not yet recruiting NCT02943031 Phase 4
12 X-MAS Biliary Study With Covered Biliary Stent Unknown status NCT01899976 Phase 3
13 Early Enteral Feeding After Pylorus Preserving Pancreatoduodenectomy Unknown status NCT00809081 Phase 3
14 Cediranib Versus Placebo Plus Cisplatin/Gemcitabine Chemotherapy for Patients With Advanced Biliary Tract Cancers Completed NCT00939848 Phase 2, Phase 3 gemcitabine;cisplatin;Placebo;cisplatin;cediranib;gemcitabine
15 Nonstented Stump-closed vs Duct-to-Mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy Completed NCT01731821 Phase 3
16 Early Palliative Care on Quality of Life of Advanced Cancer Patients Completed NCT02988635 Phase 3
17 Gemcitabine Hydrochloride and Oxaliplatin or Observation in Treating Patients With Biliary Tract Cancer That Has Been Removed by Surgery Completed NCT01313377 Phase 3 gemcitabine hydrochloride;oxaliplatin
18 Capecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer Completed NCT00363584 Phase 3 capecitabine
19 New Chemotherapy Regimen in the Treatment of Advanced Gallbladder Carcinoma Completed NCT01053390 Phase 3 Somatostatin;epirubicin, cisplatin, LV(Leucovorin)、 5-FU(5-Fluorouracil)
20 Palliative Biliary Stenting on the Quality of Life of Patients With Unresectable Carcinoma Gallbladder With Hiliar Block. Completed NCT00391183 Phase 2, Phase 3
21 Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms Completed NCT01640522 Phase 3
22 Biliary Stenting With or Without Photodynamic Therapy in Treating Patients With Locally Advanced, Recurrent, or Metastatic Cholangiocarcinoma or Other Biliary Tract Tumors That Cannot Be Removed by Surgery Completed NCT00513539 Phase 3 porfimer sodium
23 Fluorouracil, Cisplatin, and Radiation Therapy or Gemcitabine and Oxaliplatin in Treating Patients With Nonmetastatic Biliary Tract Cancer That Cannot Be Removed By Surgery Completed NCT00304135 Phase 2, Phase 3 cisplatin;gemcitabine hydrochloride;oxaliplatin
24 Gemcitabine With or Without Cisplatin in Treating Patients With Unresectable Locally Advanced or Metastatic Cholangiocarcinoma or Other Biliary Tract Tumors Completed NCT00262769 Phase 3 cisplatin;gemcitabine hydrochloride
25 Varlitinib in Combination With Capecitabine for Advanced or Metastatic Biliary Tract Cancer Recruiting NCT03093870 Phase 2, Phase 3 Varlitinib;Capecitabine;Placebo (for Varlitinib)
26 Safety and Efficacy of Modified Folfirinox Versus Gemcis in Bile Duct Tumours Recruiting NCT02591030 Phase 2, Phase 3 GEMCIS;mFolfirinox
27 Percutaneous Hepatic Perfusion vs. Cisplatin/Gemcitabine in Patients With Intrahepatic Cholangiocarcinoma Recruiting NCT03086993 Phase 2, Phase 3 Cisplatin and Gemcitabine
28 Early Palliative Care in Patients With Metastatic Upper Gastrointestinal Cancers Treated With First-line Chemotherapy Recruiting NCT02853474 Phase 3
29 Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Standard of Care After Curative Intent Resection of Biliary Tract Cancer Recruiting NCT02170090 Phase 3 Gemcitabine;Cisplatin;Capecitabine
30 Photodynamic Therapy (PDT) for Palliation of Cholangiocarcinoma Recruiting NCT01755013 Phase 2, Phase 3
31 GEM/Cisplatin/S-1 vs GEM/Cisplatin for Biliary Tract Cancer Active, not recruiting NCT02182778 Phase 3 Gemcitabine/Cisplatin;Gemcitabine/Cisplatin /S-1
32 Active Symptom Control Alone or With mFOLFOX Chemotherapy for Locally Advanced/ Metastatic Biliary Tract Cancers Active, not recruiting NCT01926236 Phase 3 L-folinic acid;5 FU;Oxaliplatin
33 Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers Active, not recruiting NCT02349412 Phase 3
34 Programmed Death Ligand (PD-L1) Combined With Chemotherapy for Patients With BTC Not yet recruiting NCT03478488 Phase 3 KN035 plus Gemcitabine & oxaliplatin;Gemcitabine & oxaliplatin
35 Study of SPARC1507 Not yet recruiting NCT02597465 Phase 3 SPARC1507;Reference1507
36 Chemotherapy Before & After Surgery in Patients With Resectable Gallbladder Cancer Not yet recruiting NCT03579758 Phase 3 Capecitabine;Cisplatin;Gemcitabine
37 Perioperative Therapy Preoperative Chemotherapy Versus Chemoradiotherapy in Locally Advanced Gall Bladder Cancers Not yet recruiting NCT02867865 Phase 2, Phase 3 Gemcitabine;Cisplatin
38 XL119 Versus 5-Fluorouracil (5-FU) Plus Leucovorin (LV) in Subjects With Advanced Biliary Tumors Terminated NCT00090025 Phase 3 becatecarin;5-Fluorouracil Plus Leucovorin
39 Gemcitabine With or Without Capecitabine in Treating Patients With Locally Advanced, Unresectable, or Metastatic Biliary Cancer Terminated NCT00658593 Phase 3 capecitabine;gemcitabine hydrochloride
40 Escitalopram in Treating Depression in Patients With Advanced Lung or Gastrointestinal Cancer Terminated NCT00387348 Phase 3 escitalopram oxalate;Placebo
41 Comparison Between Two Methods of Bilateral Stenting for Malignant Hilar Obstruction Withdrawn NCT01622803 Phase 3
42 Stent Placement With or Without Photodynamic Therapy Using Porfimer Sodium as Palliative Treatment in Treating Patients With Stage III or Stage IV Cholangiocarcinoma That Cannot Be Removed By Surgery Withdrawn NCT00253617 Phase 3 porfimer sodium
43 Immunotherapy Using Precision T Cells Specific to Personalized Neo-antigen for the Treatment of Advanced Malignant Tumor of Biliary Tract Unknown status NCT02632019 Phase 1, Phase 2 Gemcitabine
44 Effects of OXY111A in Primary and Secondary Hepato-Pancreato-Biliary Neoplasm Unknown status NCT02528526 Phase 1, Phase 2 OXY111A
45 MEK162 in Combination With Capecitabine in Advanced Biliary Tract Cancer Unknown status NCT02773459 Phase 1, Phase 2 MEK162+capecitabine
46 Study of TH-302 Monotherapy as Second-line Treatment in Advanced Biliary Tract Cancer Unknown status NCT02433639 Phase 2 TH-302 monotherapy
47 Phase II Study of FOLFOXIRI in Patients With Locally Advanced or Metastatic Biliary Tract Cancer Unknown status NCT01494363 Phase 2 Fluorouracil;Leucovorin;Oxaliplatin;Irinotecan
48 Docetaxel and Oxaliplatin Combination With Locally Advanced or Metastatic Biliary Tract Cancer Unknown status NCT01234051 Phase 2 Docetaxel, Oxaliplatin
49 Study of S-1 Oxaliplatin (SOX) for Biliary Tract Cancer (BTC) (Ampullary Adenocarcinoma) Unknown status NCT01180153 Phase 2 S-1 oxaliplatin
50 SOX Sequential S-1 in Advanced Biliary Tract Carcinoma(BTC)and Pancreatic Cancer Unknown status NCT01811277 Phase 2 SOX sequential S-1

Search NIH Clinical Center for Biliary Tract Neoplasm

Genetic Tests for Biliary Tract Neoplasm

Genetic tests related to Biliary Tract Neoplasm:

# Genetic test Affiliating Genes
1 Biliary Tract Neoplasm 29

Anatomical Context for Biliary Tract Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Biliary Tract Neoplasm:

19
The Biliary Tract

MalaCards organs/tissues related to Biliary Tract Neoplasm:

41
Liver, Lung, Small Intestine, Pancreas, Testes, T Cells, Nk Cells

Publications for Biliary Tract Neoplasm

Articles related to Biliary Tract Neoplasm:

# Title Authors Year
1
Utility of convex EUS for preoperative vascular evaluation of malignant biliary tract neoplasm. ( 29468057 )
2018
2
Imaging features and appropriate treatment strategy of a rare biliary tract neoplasm. ( 23823837 )
2013
3
Epidemiological aspects of gallbladder and biliary tract neoplasm. ( 5008636 )
1972

Variations for Biliary Tract Neoplasm

Cosmic variations for Biliary Tract Neoplasm:

9
(show top 50) (show all 1006)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6974042 ZFHX3 biliary tract,bile duct,carcinoma,NS c.6964C>T p.R2322* 16:72795718-72795718 18
2 COSM6957143 ZFHX3 biliary tract,bile duct,carcinoma,NS c.3529+1G>A p.? 16:72829778-72829778 18
3 COSM6928728 YAP1 biliary tract,bile duct,carcinoma,NS c.434C>G p.T145S 11:102114256-102114256 18
4 COSM6986174 XPO1 biliary tract,bile duct,carcinoma,NS c.273G>T p.W91C 2:61522639-61522639 18
5 COSM6975271 XPO1 biliary tract,bile duct,carcinoma,NS c.729G>T p.E243D 2:61498703-61498703 18
6 COSM6985358 XPO1 biliary tract,bile duct,carcinoma,NS c.338C>T p.T113M 2:61502274-61502274 18
7 COSM6923580 TSC1 biliary tract,bile duct,carcinoma,NS c.2551C>T p.Q851* 9:132900789-132900789 18
8 COSM4172016 TSC1 biliary tract,bile duct,carcinoma,NS c.737+1G>A p.? 9:132921362-132921362 18
9 COSM308173 TRIM28 biliary tract,bile duct,carcinoma,NS c.1475G>T p.R492L 19:58549053-58549053 18
10 COSM44463 TP53 biliary tract,bile duct,carcinoma,NS c.848G>T p.R283L 17:7673772-7673772 18
11 COSM43687 TP53 biliary tract,bile duct,carcinoma,NS c.641A>G p.H214R 17:7674890-7674890 18
12 COSM10687 TP53 biliary tract,bile duct,carcinoma,NS c.527G>A p.C176Y 17:7675085-7675085 18
13 COSM10731 TP53 biliary tract,bile duct,carcinoma,NS c.707A>G p.Y236C 17:7674256-7674256 18
14 COSM10662 TP53 biliary tract,bile duct,carcinoma,NS c.743G>A p.R248Q 17:7674220-7674220 18
15 COSM10722 TP53 biliary tract,bile duct,carcinoma,NS c.853G>A p.E285K 17:7673767-7673767 18
16 COSM43778 TP53 biliary tract,bile duct,carcinoma,NS c.713G>T p.C238F 17:7674250-7674250 18
17 COSM44426 TP53 biliary tract,bile duct,carcinoma,NS c.568C>G p.P190A 17:7674963-7674963 18
18 COSM44309 TP53 biliary tract,bile duct,carcinoma,NS c.440T>G p.V147G 17:7675172-7675172 18
19 COSM11073 TP53 biliary tract,bile duct,carcinoma,NS c.1024C>T p.R342* 17:7670685-7670685 18
20 COSM43751 TP53 biliary tract,bile duct,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 18
21 COSM43635 TP53 biliary tract,bile duct,carcinoma,NS c.536A>T p.H179L 17:7675076-7675076 18
22 COSM22908 TP53 biliary tract,bile duct,carcinoma,NS c.376-1G>T p.? 17:7675237-7675237 18
23 COSM44143 TP53 biliary tract,bile duct,carcinoma,NS c.919+1G>A p.? 17:7673700-7673700 18
24 COSM10727 TP53 biliary tract,bile duct,carcinoma,NS c.438G>A p.W146* 17:7675174-7675174 18
25 COSM44786 TP53 biliary tract,bile duct,carcinoma,NS c.694A>C p.I232L 17:7674269-7674269 18
26 COSM10648 TP53 biliary tract,bile duct,carcinoma,NS c.524G>A p.R175H 17:7675088-7675088 18
27 COSM10660 TP53 biliary tract,bile duct,carcinoma,NS c.818G>A p.R273H 17:7673802-7673802 18
28 COSM43596 TP53 biliary tract,bile duct,carcinoma,NS c.841G>A p.D281N 17:7673779-7673779 18
29 COSM11090 TP53 biliary tract,bile duct,carcinoma,NS c.541C>T p.R181C 17:7675071-7675071 18
30 COSM10690 TP53 biliary tract,bile duct,carcinoma,NS c.473G>A p.R158H 17:7675139-7675139 18
31 COSM10656 TP53 biliary tract,bile duct,carcinoma,NS c.742C>T p.R248W 17:7674221-7674221 18
32 COSM11071 TP53 biliary tract,bile duct,carcinoma,NS c.1009C>T p.R337C 17:7670700-7670700 18
33 COSM10749 TP53 biliary tract,bile duct,carcinoma,NS c.830G>T p.C277F 17:7673790-7673790 18
34 COSM44262 TP53 biliary tract,bile duct,carcinoma,NS c.808T>C p.F270L 17:7673812-7673812 18
35 COSM11078 TP53 biliary tract,bile duct,carcinoma,NS c.1027G>T p.E343* 17:7670682-7670682 18
36 COSM10659 TP53 biliary tract,bile duct,carcinoma,NS c.817C>T p.R273C 17:7673803-7673803 18
37 COSM10883 TP53 biliary tract,bile duct,carcinoma,NS c.731G>A p.G244D 17:7674232-7674232 18
38 COSM44523 TP53 biliary tract,bile duct,carcinoma,NS c.863A>G p.N288S 17:7673757-7673757 18
39 COSM10672 TP53 biliary tract,bile duct,carcinoma,NS c.577C>T p.H193Y 17:7674954-7674954 18
40 COSM11355 TP53 biliary tract,bile duct,carcinoma,NS c.737T>C p.M246T 17:7674226-7674226 18
41 COSM44226 TP53 biliary tract,bile duct,carcinoma,NS c.380C>T p.S127F 17:7675232-7675232 18
42 COSM10725 TP53 biliary tract,bile duct,carcinoma,NS c.701A>G p.Y234C 17:7674262-7674262 18
43 COSM69404 TP53 biliary tract,bile duct,carcinoma,NS c.994-1G>A p.? 17:7670716-7670716 18
44 COSM10893 TP53 biliary tract,bile duct,carcinoma,NS c.824G>A p.C275Y 17:7673796-7673796 18
45 COSM45025 TP53 biliary tract,bile duct,carcinoma,NS c.488A>C p.Y163S 17:7675124-7675124 18
46 COSM6918 TP53 biliary tract,bile duct,carcinoma,NS c.993+1G>T p.? 17:7673534-7673534 18
47 COSM10738 TP53 biliary tract,bile duct,carcinoma,NS c.542G>A p.R181H 17:7675070-7675070 18
48 COSM44623 TP53 biliary tract,bile duct,carcinoma,NS c.487T>A p.Y163N 17:7675125-7675125 18
49 COSM44271 TP53 biliary tract,bile duct,carcinoma,NS c.688A>C p.T230P 17:7674275-7674275 18
50 COSM44215 TP53 biliary tract,bile duct,carcinoma,NS c.533A>C p.H178P 17:7675079-7675079 18

Expression for Biliary Tract Neoplasm

Search GEO for disease gene expression data for Biliary Tract Neoplasm.

Pathways for Biliary Tract Neoplasm

Pathways related to Biliary Tract Neoplasm according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.59 CDKN2A CDX2 MUC1 MUC2 MUC4 SMAD4
2
Show member pathways
12.68 CDKN2A HRAS KRAS TP53
3
Show member pathways
12.67 CDKN2A HRAS KRAS SMAD4 TP53
4 12.63 CDKN2A HRAS KRAS SMAD4 TP53
5
Show member pathways
12.62 CDKN2A HRAS KRAS TP53
6
Show member pathways
12.39 HRAS KRAS SMAD4 TP53
7 12.33 CDKN2A HRAS KRAS TP53
8
Show member pathways
12.32 HRAS KRAS MUC1 SMAD4 TP53
9 12.18 HRAS KRAS TP53
10
Show member pathways
12.13 MUC1 MUC2 MUC4
11
Show member pathways
12.13 HRAS KRAS MUC1 MUC2 MUC4
12 12.1 CDKN2A HRAS KRAS TP53
13
Show member pathways
12.08 HRAS KRAS TP53
14 12.07 KRAS SMAD4 TP53
15 12.06 CDKN2A HRAS KRAS SMAD4 TP53
16
Show member pathways
12.05 HRAS KRAS TP53
17 12.03 KRAS SMAD4 TP53
18
Show member pathways
12.02 HRAS KRAS TP53
19
Show member pathways
12.01 HRAS KRAS TP53
20
Show member pathways
11.98 MUC1 MUC2 MUC4
21 11.98 CDKN2A HRAS KRAS TP53
22 11.96 HRAS KRAS SMAD4
23 11.95 CDKN2A SMAD4 TP53
24
Show member pathways
11.95 HRAS KRAS SMAD4
25 11.94 HRAS KRAS SMAD4
26 11.92 HRAS KRAS TP53
27 11.86 HRAS KRAS TP53
28 11.84 HRAS KRAS TP53
29
Show member pathways
11.83 CDKN2A CDX2 HRAS KRAS MUC2 SMAD4
30
Show member pathways
11.8 MUC1 MUC2 MUC4
31 11.76 HRAS KRAS SMAD4
32 11.75 CDKN2A HRAS KRAS TP53
33 11.69 CDKN2A HRAS SMAD4 TP53
34 11.54 HRAS KRAS TP53
35 11.53 HRAS KRAS TP53
36 11.41 CDKN2A HRAS KRAS SMAD4 TP53
37 11.32 CDKN2A HRAS KRAS TP53
38 11.18 HRAS KRAS
39
Show member pathways
11.17 HRAS KRAS
40 11.17 HRAS KRAS TP53
41
Show member pathways
11.11 HRAS KRAS
42 11.11 HRAS KRAS SMAD4
43 11.05 HRAS KRAS
44 11.03 HRAS KRAS
45 11.03 CDKN2A TP53
46
Show member pathways
11.02 CDKN2A TP53
47 11 MUC2 SMAD4
48 10.97 HRAS KRAS
49 10.72 HRAS KRAS

GO Terms for Biliary Tract Neoplasm

Cellular components related to Biliary Tract Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC1 MUC2 MUC4

Biological processes related to Biliary Tract Neoplasm according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 CDKN2A CDX2 SMAD4 TP53
2 negative regulation of cell proliferation GO:0008285 9.76 CDKN2A HRAS SMAD4 TP53
3 axon guidance GO:0007411 9.73 HRAS KRAS SMAD4
4 cell cycle arrest GO:0007050 9.69 CDKN2A HRAS TP53
5 positive regulation of gene expression GO:0010628 9.67 CDKN2A HRAS KRAS TP53
6 negative regulation of cell growth GO:0030308 9.61 CDKN2A SMAD4 TP53
7 intrinsic apoptotic signaling pathway GO:0097193 9.58 HRAS TP53
8 cell aging GO:0007569 9.57 HRAS TP53
9 cellular response to gamma radiation GO:0071480 9.55 HRAS TP53
10 cellular senescence GO:0090398 9.54 CDKN2A HRAS
11 regulation of long-term neuronal synaptic plasticity GO:0048169 9.52 HRAS KRAS
12 positive regulation of cellular senescence GO:2000774 9.49 CDKN2A KRAS
13 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.48 MUC1 TP53
14 replicative senescence GO:0090399 9.4 CDKN2A TP53
15 O-glycan processing GO:0016266 9.33 MUC1 MUC2 MUC4
16 maintenance of gastrointestinal epithelium GO:0030277 9.32 MUC2 MUC4
17 response to isolation stress GO:0035900 9.26 HRAS KRAS
18 Ras protein signal transduction GO:0007265 9.26 CDKN2A HRAS KRAS TP53
19 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.02 HRAS KRAS MUC1 MUC2 MUC4

Sources for Biliary Tract Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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