MCID: BNS003
MIFTS: 45

Binswanger's Disease

Categories: Rare diseases, Mental diseases

Aliases & Classifications for Binswanger's Disease

MalaCards integrated aliases for Binswanger's Disease:

Name: Binswanger's Disease 53 54
Multi-Infarct Dementia 53 73
Dementia Multi-Infarct 53 55
Binswanger Disease 55 73
Dementia - Multi-Infarct 54

Classifications:



External Ids:

UMLS 73 C0270786

Summaries for Binswanger's Disease

NINDS : 54 Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists callexecutive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis.  

MalaCards based summary : Binswanger's Disease, also known as multi-infarct dementia, is related to subcortical arteriosclerotic encephalopathy and vascular dementia. An important gene associated with Binswanger's Disease is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and G-protein signaling_Regulation of RAC1 activity. The drugs Buprenorphine and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and globus pallidus, and related phenotypes are behavior/neurological and growth/size/body region

NIH Rare Diseases : 53 Binswanger's disease is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. Most affected people experience progressive memory loss and deterioration of intellectual abilities (dementia); urinary urgency or incontinence; and an abnormally slow, unsteady gait (style of walking). While there is no cure, the progression of Binswanger's disease can be slowed with healthy lifestyle choices. Treatment is based on the signs and symptoms present in each person.

Wikipedia : 76 Binswanger\'s disease, also known as subcortical leukoencephalopathy, is a form of small vessel vascular... more...

Related Diseases for Binswanger's Disease

Diseases related to Binswanger's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 subcortical arteriosclerotic encephalopathy 32.8 GFAP VIP
2 vascular dementia 31.5 ACHE APOE APP MAPT NOTCH3
3 dementia 28.5 ACHE APOE APP MAPT NOTCH3
4 alzheimer disease 26.7 ACHE APOE APP CRH GFAP MAPT
5 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 12.2
6 esophageal neuroendocrine tumor 11.0 CHGA SYP
7 ureter small cell carcinoma 11.0 CHGA SYP
8 urinary bladder small cell neuroendocrine carcinoma 10.9 CHGA SYP
9 ovarian large-cell neuroendocrine carcinoma 10.9 CHGA SYP
10 auditory system cancer 10.9 CHGA SYP
11 acinar cell cystadenocarcinoma 10.9 CHGA SYP
12 peritoneal serous adenocarcinoma 10.9 CHGA SYP
13 gallbladder small cell carcinoma 10.9 CHGA SYP
14 primary hepatic neuroendocrine carcinoma 10.9 CHGA SYP
15 small cell carcinoma of the bladder 10.9 CHGA SYP
16 malignant glandular tumor of peripheral nerve sheath 10.9 SST SYP
17 pulmonary large cell neuroendocrine carcinoma 10.9 CHGA SYP
18 atypical follicular adenoma 10.9 CHGA SYP
19 pancreatic somatostatinoma 10.9 SST SYP
20 gastrointestinal neuroendocrine benign tumor 10.9 CHGA SST
21 olfactory nerve neoplasm 10.9 CHGA SYP
22 gastric neuroendocrine neoplasm 10.9 CHGA SST
23 cauda equina neoplasm 10.9 CHGA SYP
24 pancreatic serous cystadenoma 10.9 CHGA SYP
25 conventional angiosarcoma 10.9 CHGA SYP
26 nodular ganglioneuroblastoma 10.8 CHGA SYP
27 desmoplastic infantile ganglioglioma 10.8 GFAP SYP
28 extraventricular neurocytoma 10.8 GFAP SYP
29 lung combined type small cell carcinoma 10.8 GFAP SYP
30 pulmonary sclerosing hemangioma 10.8 CHGA SYP
31 hyperinsulinemic hypoglycemia, familial, 2 10.8 CHGA SST
32 respiratory system benign neoplasm 10.8 CHGA SYP
33 gastric squamous cell carcinoma 10.8 CHGA SYP
34 rhabdoid meningioma 10.8 GFAP SYP
35 gastric small cell carcinoma 10.8 CHGA SYP
36 pilomyxoid astrocytoma 10.8 GFAP SYP
37 central nervous system primitive neuroectodermal neoplasm 10.8 GFAP SYP
38 glycogen-rich clear cell breast carcinoma 10.8 ACTC1 SYP
39 subependymal glioma 10.8 GFAP SYP
40 myofibromatosis, infantile, 1 10.8 ACTC1 NOTCH3
41 chiari malformation 10.8 GFAP SYP
42 dysembryoplastic neuroepithelial tumor 10.8 GFAP SYP
43 anaplastic ganglioglioma 10.8 ACTC1 GFAP
44 cerebral neuroblastoma 10.8 GFAP SYP
45 benign ependymoma 10.7 GFAP SYP
46 clear cell meningioma 10.7 CHGA GFAP
47 astroblastoma 10.7 GFAP SYP
48 pulmonary blastoma 10.7 CHGA SYP
49 cerebral ventricle cancer 10.7 GFAP SYP
50 cutaneous leiomyosarcoma 10.7 ACTC1 GFAP

Graphical network of the top 20 diseases related to Binswanger's Disease:



Diseases related to Binswanger's Disease

Symptoms & Phenotypes for Binswanger's Disease

MGI Mouse Phenotypes related to Binswanger's Disease:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 GFAP APP ACHE APOE CRH SYP
2 growth/size/body region MP:0005378 10.23 GFAP APP ACHE ACTC1 CHGA APOE
3 homeostasis/metabolism MP:0005376 10.21 GFAP APP ACHE ACTC1 CHGA APOE
4 cardiovascular system MP:0005385 10.15 APOE APP CHGA ACTC1 NOTCH3 GFAP
5 mortality/aging MP:0010768 10.15 APP ACHE ACTC1 CHGA APOE NOTCH3
6 cellular MP:0005384 10.13 CRH APOE APP ACTC1 NOTCH3 GFAP
7 immune system MP:0005387 10.06 CRH APOE APP SST NOTCH3 GFAP
8 nervous system MP:0003631 10 GFAP APP ACHE APOE CRH SYP
9 muscle MP:0005369 9.92 APOE APP ACHE ACTC1 NOTCH3 GFAP
10 no phenotypic analysis MP:0003012 9.7 CRH APOE APP ACHE CHGA MAPT
11 normal MP:0002873 9.61 APP ACTC1 CRH NOTCH3 SYP VIP
12 reproductive system MP:0005389 9.17 APOE ACHE APP CHGA NOTCH3 PLP1

Drugs & Therapeutics for Binswanger's Disease

Drugs for Binswanger's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
2
Acetaminophen Approved Phase 4 103-90-2 1983
3 Analgesics Phase 4
4 Central Nervous System Depressants Phase 4
5 Narcotic Antagonists Phase 4
6 Narcotics Phase 4
7 Analgesics, Non-Narcotic Phase 4
8 Analgesics, Opioid Phase 4
9 Peripheral Nervous System Agents Phase 4,Phase 3
10 Antipyretics Phase 4
11
Amlodipine Approved Phase 3 88150-42-9 2162
12
Losartan Approved Phase 3 114798-26-4 3961
13
Atenolol Approved Phase 3 29122-68-7 2249
14
Angiotensin II Approved, Investigational Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
15 Neurotransmitter Agents Phase 3,Phase 2
16 calcium channel blockers Phase 3
17 Adrenergic Agents Phase 3
18 Adrenergic Antagonists Phase 3
19 Adrenergic beta-1 Receptor Antagonists Phase 3
20 Adrenergic beta-Antagonists Phase 3
21 Sympatholytics Phase 3
22 Angiotensin II Type 1 Receptor Blockers Phase 3
23 Angiotensin Receptor Antagonists Phase 3
24 Angiotensinogen Phase 3
25 Anti-Arrhythmia Agents Phase 3
26 Vasodilator Agents Phase 3
27 Antihypertensive Agents Phase 3
28 Autonomic Agents Phase 3
29 Calcium, Dietary Phase 3
30
Donepezil Approved Phase 2 120014-06-4 3152
31
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
32 Dabigatran Phase 2
33
protease inhibitors Phase 2
34 Serine Proteinase Inhibitors Phase 2
35 HIV Protease Inhibitors Phase 2
36 Anticoagulants Phase 2
37 Antithrombin III Phase 2
38 Antithrombins Phase 2
39 Cholinergic Agents Phase 2
40 Cholinesterase Inhibitors Phase 2
41 Nootropic Agents Phase 2

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Efficacy of Pain Treatment on Depression in Patients With Dementia Completed NCT02267057 Phase 4 Paracetamol;Buprenorphine;Paracetamol placebo;Buprenorphine placebo
2 Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function Recruiting NCT03082014 Phase 3 Amlodipine;Losartan;Atenolol
3 Safety Study of Dabigatran in CADASIL Unknown status NCT01361763 Phase 2 Dabigatran;Antiplatelets
4 The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment Completed NCT00103948 Phase 2 Aricept
5 Secondary Prevention of Stroke Through Non-drug Therapeutic Weight Reduction Unknown status NCT01721538 Not Applicable
6 Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Unknown status NCT02071784
7 Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control Studies Unknown status NCT02196532
8 Identification of Biomarkers Sensitive to Disease Progression in Patients With Mild Cognitive Impairment Completed NCT01425957 Not Applicable
9 Research Study on Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Completed NCT01114815
10 The Silent Cortical Infarcts in the Cerebral Amyloid Angiopathy: Is There a Link With Subarachnoid Hemorrhage? Completed NCT02837354
11 Impact of tDCS on Cerebral Autoregulation Completed NCT01865604 Not Applicable
12 Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysis Completed NCT01928212
13 CADASIL Disease Discovery Recruiting NCT02821780
14 Generation of a Cellular Model of CADASIL From Skin Fibroblasts Enrolling by invitation NCT02032225

Search NIH Clinical Center for Binswanger's Disease

Genetic Tests for Binswanger's Disease

Anatomical Context for Binswanger's Disease

MalaCards organs/tissues related to Binswanger's Disease:

41
Brain, Skin, Globus Pallidus, Endothelial, Smooth Muscle

Publications for Binswanger's Disease

Articles related to Binswanger's Disease:

(show top 50) (show all 122)
# Title Authors Year
1
Binswanger's disease: Biomarkers in the inflammatory form of vascular cognitive impairment and dementia. ( 28902409 )
2017
2
Multi-infarct dementia and Alzheimer disease, contribution of cerebral circulation ultrasonography to pathogenesis and differential diagnosis. Value of microembolisation. ( 27179577 )
2016
3
Comparison of medial temporal measures between Binswanger's disease and Alzheimer's disease. ( 24466084 )
2014
4
Binswanger's disease: toward a diagnosis agreement and therapeutic approach. ( 25201523 )
2014
5
MRI features of Binswanger's disease predict prognosis and associated pathology. ( 25493272 )
2014
6
Effects of acupuncture on declined cerebral blood flow, impaired mitochondrial respiratory function and oxidative stress in multi-infarct dementia rats. ( 24361538 )
2013
7
Morphometric characterization of Binswanger's disease: comparison with Alzheimer's disease. ( 21708443 )
2012
8
Vascular cognitive impairment in small vessel disease: clinical and neuropsychological features of lacunar state and Binswanger's disease. ( 21239411 )
2011
9
Binswanger's disease and quantitative fractional anisotropy. ( 19547805 )
2009
10
Lateralization of hippocampal nitric oxide mediator system in people with Alzheimer disease, multi-infarct dementia and schizophrenia. ( 18647632 )
2008
11
Different responses to rivastigmine in subcortical vascular dementia and multi-infarct dementia. ( 18184948 )
2008
12
The corpus callosum in Binswanger's disease: A quantitative fractional anisotropy analysis. ( 29213585 )
2008
13
Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease. ( 18617735 )
2008
14
Hereditary multi-infarct dementia of the Swedish type is a novel disorder different from NOTCH3 causing CADASIL. ( 17235124 )
2007
15
Binswanger's disease. ( 17694788 )
2007
16
Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease. ( 17403574 )
2007
17
Small artery dementia in Japan: radiological differences between CADASIL, leukoaraiosis and Binswanger's disease. ( 16391479 )
2006
18
From Binswanger's disease to leuokoaraiosis: what we have learned about subcortical vascular dementia. ( 15595361 )
2004
19
Cerebral blood flow patterns in Binswanger's disease: a SPECT study using three-dimensional stereotactic surface projections. ( 15140610 )
2004
20
Pathology of the cerebral artery in Binswanger's disease in the aged: observation by serial sections and morphometry of the cerebral arteries. ( 15068169 )
2004
21
Topographical and cytopathological lesion analysis of the white matter in Binswanger's disease brains. ( 15088098 )
2004
22
Cerebral microbleeds in Binswanger's disease: a gradient-echo T2*-weighted magnetic resonance imaging study. ( 12672544 )
2003
23
Binswanger's disease: its association with hypertension and obstructive sleep apnea. ( 12858817 )
2003
24
-174 G/C interleukin-6 gene polymorphism and increased risk of multi-infarct dementia: a case-control study. ( 12086705 )
2002
25
Increased blood-brain barrier permeability in white matter lesions of Binswanger's disease evaluated by contrast-enhanced MRI. ( 12053125 )
2002
26
Blood pressure variability in Binswanger's disease and isolated lacunar infarction. ( 11306773 )
2001
27
Increasing in situ nick end labeling of oligodendrocytes in white matter of patients with Binswanger's disease. ( 17903801 )
2001
28
Thrombin and antithrombin in Binswanger's disease. ( 11065234 )
2000
29
Binswanger's disease is not a single entity. ( 11441570 )
2000
30
Vascular cell components of the medullary arteries in Binswanger's disease brains: a morphometric and immunoelectron microscopic study. ( 10926944 )
2000
31
Binswanger's disease: an ongoing controversy. ( 10956563 )
2000
32
A study of platelet organelles and membrane glycoprotein in patients with Binswanger's disease. ( 11717951 )
1999
33
Cytopathological alterations and therapeutic approaches in Binswanger's disease. ( 19519655 )
1999
34
Effects of antithrombin on Binswanger's disease with antiphospholipid antibody syndrome. ( 9932966 )
1999
35
Magnetization transfer ratio in cerebral white matter lesions of Binswanger's disease. ( 10475100 )
1999
36
Change of tumor necrosis factor-alpha levels in patients with Binswanger's disease. ( 12899375 )
1999
37
Rheologic determinant changes of erythrocytes in Binswanger's disease. ( 10063717 )
1999
38
Increased coagulatory activity in subcortical arteriosclerotic encephalopathy (Binswanger's disease) ( 9987717 )
1999
39
Blood-brain barrier dysfunction in Binswanger's disease; an immunohistochemical study. ( 9452825 )
1998
40
Binswanger's disease. A rare cause of dementia in elderly persons. ( 9591403 )
1998
41
Auditory P300, CT scans and cognitive state in Binswanger's disease. ( 9170551 )
1997
42
Alterations in glia and axons in the brains of Binswanger's disease patients. ( 9227695 )
1997
43
Apolipoprotein E genotypes and serum lipid levels in Alzheimer's disease and multi-infarct dementia. ( 9152721 )
1997
44
The angiopathy of subcortical arteriosclerotic encephalopathy (Binswanger's disease): immunohistochemical studies using markers for components of extracellular matrix, smooth muscle actin and endothelial cells. ( 9083552 )
1997
45
The role of endothelin-1 in Binswanger's disease. ( 8940785 )
1996
46
Multimodal evoked potentials in Alzheimer's disease and Binswanger's disease. ( 8679063 )
1996
47
From UBOs to Binswanger's disease. Impact of magnetic resonance imaging on vascular dementia research. ( 8711785 )
1996
48
The apolipoprotein E gene in Binswanger's disease and vascular dementia. ( 9147873 )
1996
49
Somatostatin, its molecular forms and monoaminergic transmitter metabolites in Binswanger's disease. Neurochemical-neuropathological considerations. ( 9117548 )
1996
50
Differences in dexamethasone-sensitivity between lymphocytes from patients with Alzheimer's disease and patients with multi-infarct dementia. ( 8811935 )
1996

Variations for Binswanger's Disease

Expression for Binswanger's Disease

Search GEO for disease gene expression data for Binswanger's Disease.

Pathways for Binswanger's Disease

Pathways related to Binswanger's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.7 APOE APP GFAP MAPT NOTCH3 SYP
2 11.01 APOE APP MAPT
3 10.79 APOE APP MAPT

GO Terms for Binswanger's Disease

Cellular components related to Binswanger's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 ACHE ACTC1 APOE APP CHGA CRH
2 neuronal cell body GO:0043025 9.71 APOE CRH MAPT SST
3 cell body GO:0044297 9.43 ACTC1 GFAP MAPT
4 astrocyte projection GO:0097449 9.32 APP GFAP
5 extracellular region GO:0005576 9.32 ACHE APOE APP CHGA CRH MAPT
6 main axon GO:0044304 9.16 APP MAPT
7 neuromuscular junction GO:0031594 9.13 ACHE APP SYP

Biological processes related to Binswanger's Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.83 ACTC1 APP CRH PLP1
2 neuron projection development GO:0031175 9.72 APP MAPT PLP1
3 artery morphogenesis GO:0048844 9.58 APOE NOTCH3
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.57 APP SYP
5 response to lead ion GO:0010288 9.56 APP MAPT
6 negative regulation of gene expression GO:0010629 9.56 APOE APP CRH MAPT
7 regulation of neuronal synaptic plasticity GO:0048168 9.54 APOE SYP
8 astrocyte development GO:0014002 9.51 GFAP PLP1
9 regulation of NMDA receptor activity GO:2000310 9.49 APP CRH
10 locomotory exploration behavior GO:0035641 9.48 APOE CRH
11 amyloid precursor protein metabolic process GO:0042982 9.46 ACHE APOE
12 amyloid fibril formation GO:1990000 9.43 APP MAPT
13 neuron projection regeneration GO:0031102 9.4 APOE GFAP
14 negative regulation of long-term synaptic potentiation GO:1900272 9.37 APOE APP
15 astrocyte activation GO:0048143 9.32 APP MAPT
16 hormone-mediated apoptotic signaling pathway GO:0008628 9.16 CRH SST
17 positive regulation of amyloid fibril formation GO:1905908 8.96 APOE APP
18 axon development GO:0061564 8.8 GFAP MAPT PLP1

Molecular functions related to Binswanger's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 APOE APP GFAP MAPT NOTCH3 SYP
2 hormone activity GO:0005179 9.33 CRH SST VIP
3 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Binswanger's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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