MCID: BNS003
MIFTS: 47

Binswanger's Disease

Categories: Rare diseases

Aliases & Classifications for Binswanger's Disease

MalaCards integrated aliases for Binswanger's Disease:

Name: Binswanger's Disease 54 55
Multi-Infarct Dementia 54 74
Dementia Multi-Infarct 54 56
Binswanger Disease 56 74
Dementia - Multi-Infarct 55

Classifications:



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Summaries for Binswanger's Disease

NINDS : 55 Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists callexecutive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis.  

MalaCards based summary : Binswanger's Disease, also known as multi-infarct dementia, is related to subcortical arteriosclerotic encephalopathy and hydrocephalus, normal-pressure. An important gene associated with Binswanger's Disease is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Reelin Pathway (Cajal-Retzius cells). The drugs Acetaminophen and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and testes, and related phenotypes are behavior/neurological and growth/size/body region

NIH Rare Diseases : 54 Binswanger's disease is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. Most affected people experience progressive memory loss and deterioration of intellectual abilities (dementia); urinary urgency or incontinence; and an abnormally slow, unsteady gait (style of walking). While there is no cure, the progression of Binswanger's disease can be slowed with healthy lifestyle choices. Treatment is based on the signs and symptoms present in each person.

Wikipedia : 77 Binswanger''s disease, also known as subcortical leukoencephalopathy and subcortical arteriosclerotic... more...

Related Diseases for Binswanger's Disease

Diseases related to Binswanger's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 subcortical arteriosclerotic encephalopathy 32.6 GFAP VIP
2 hydrocephalus, normal-pressure 30.3 APOE MAPT
3 dementia 29.8 ACHE APOE APP MAPT NOTCH3
4 cerebral amyloid angiopathy, cst3-related 29.6 APOE APP MAPT
5 vascular dementia 29.3 ACHE APOE APP MAPT NOTCH3
6 hydrocephalus 29.3 APOE APP GFAP MAPT SYP
7 alzheimer disease 28.9 ACHE APOE APP CRH GFAP MAPT
8 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 12.4
9 dementia - subcortical 11.1
10 encephalopathy 10.7
11 cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 10.6
12 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 10.6
13 glomus tumor 10.5 ACTC1 SYP
14 functional colonic disease 10.5 SST SYP
15 ureter small cell carcinoma 10.5 CHGA SYP
16 esophageal neuroendocrine tumor 10.4 CHGA SYP
17 urinary bladder small cell neuroendocrine carcinoma 10.4 CHGA SYP
18 duodenal gastrinoma 10.4 CHGA SST
19 ovarian large-cell neuroendocrine carcinoma 10.4 CHGA SYP
20 auditory system cancer 10.4 CHGA SYP
21 acinar cell cystadenocarcinoma 10.4 CHGA SYP
22 peritoneal serous adenocarcinoma 10.4 CHGA SYP
23 primary hepatic neuroendocrine carcinoma 10.4 CHGA SYP
24 small cell carcinoma of the bladder 10.4 CHGA SYP
25 pulmonary large cell neuroendocrine carcinoma 10.4 CHGA SYP
26 papilloma of choroid plexus 10.4 GFAP SYP
27 malignant glandular tumor of peripheral nerve sheath 10.4 SST SYP
28 pineoblastoma 10.4 GFAP SYP
29 gallbladder small cell carcinoma 10.4 CHGA SYP
30 atypical follicular adenoma 10.4 CHGA SYP
31 olfactory groove meningioma 10.4 CHGA SYP
32 pancreatic somatostatinoma 10.4 SST SYP
33 cauda equina neoplasm 10.4 CHGA SYP
34 gastrointestinal neuroendocrine benign tumor 10.4 CHGA SST
35 pancreatic serous cystadenoma 10.4 CHGA SYP
36 conventional angiosarcoma 10.4 CHGA SYP
37 gastric neuroendocrine neoplasm 10.4 CHGA SST
38 myofibromatosis, infantile, 1 10.4 ACTC1 NOTCH3
39 desmoplastic infantile ganglioglioma 10.4 GFAP SYP
40 extraventricular neurocytoma 10.4 GFAP SYP
41 olfactory nerve neoplasm 10.4 CHGA SYP
42 anaplastic ganglioglioma 10.4 ACTC1 GFAP
43 pancreatic endocrine carcinoma 10.4 SST SYP
44 lung combined type small cell carcinoma 10.4 GFAP SYP
45 cutaneous leiomyosarcoma 10.4 ACTC1 GFAP
46 parachordoma 10.4 ACTC1 GFAP
47 syringocystadenoma papilliferum 10.4 ACTC1 GFAP
48 nodular ganglioneuroblastoma 10.4 CHGA SYP
49 non-langerhans-cell histiocytosis 10.4 ACTC1 SST
50 central nervous system primitive neuroectodermal neoplasm 10.4 GFAP SYP

Graphical network of the top 20 diseases related to Binswanger's Disease:



Diseases related to Binswanger's Disease

Symptoms & Phenotypes for Binswanger's Disease

MGI Mouse Phenotypes related to Binswanger's Disease:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.26 ACHE APOE APP CRH GFAP MAPT
2 growth/size/body region MP:0005378 10.26 ACHE ACTC1 APOE APP CHGA CRH
3 homeostasis/metabolism MP:0005376 10.23 ACHE ACTC1 APOE APP CHGA CRH
4 mortality/aging MP:0010768 10.18 ACHE ACTC1 APOE APP CHGA GFAP
5 cardiovascular system MP:0005385 10.16 ACTC1 APOE APP CHGA GFAP MAPT
6 cellular MP:0005384 10.15 ACTC1 APOE APP CRH GFAP MAPT
7 nervous system MP:0003631 10.1 ACHE APOE APP CHGA CRH GFAP
8 immune system MP:0005387 10.09 APOE APP CRH GFAP MAPT NOTCH3
9 muscle MP:0005369 10.02 ACHE ACTC1 APOE APP CHGA GFAP
10 normal MP:0002873 9.81 ACTC1 APP CRH GFAP MAPT NOTCH3
11 no phenotypic analysis MP:0003012 9.8 ACHE APOE APP CHGA CRH MAPT
12 reproductive system MP:0005389 9.5 ACHE APOE APP CHGA NOTCH3 PLP1
13 vision/eye MP:0005391 9.17 ACHE APOE GFAP MAPT NOTCH3 PLP1

Drugs & Therapeutics for Binswanger's Disease

Drugs for Binswanger's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
3 Central Nervous System Depressants Phase 4
4 Peripheral Nervous System Agents Phase 4,Phase 3
5 Analgesics, Opioid Phase 4
6 Antipyretics Phase 4
7 Narcotics Phase 4
8 Analgesics Phase 4
9 Narcotic Antagonists Phase 4
10 Analgesics, Non-Narcotic Phase 4
11
Amlodipine Approved Phase 3 88150-42-9 2162
12
Atenolol Approved Phase 3 29122-68-7 2249
13
Losartan Approved Phase 3 114798-26-4 3961
14
Angiotensin II Approved, Investigational Phase 3 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
15
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
16 Neurotransmitter Agents Phase 3,Phase 2
17 Antihypertensive Agents Phase 3
18 Giapreza Phase 3
19 Adrenergic Agents Phase 3
20 Calcium, Dietary Phase 3
21 Sympatholytics Phase 3
22 calcium channel blockers Phase 3
23 Angiotensin II Type 1 Receptor Blockers Phase 3
24 Anti-Arrhythmia Agents Phase 3
25 Hormones Phase 3
26 Adrenergic beta-1 Receptor Antagonists Phase 3
27 Angiotensinogen Phase 3
28 Autonomic Agents Phase 3
29 Adrenergic beta-Antagonists Phase 3
30 Angiotensin Receptor Antagonists Phase 3
31 Adrenergic Antagonists Phase 3
32 Vasodilator Agents Phase 3
33
Donepezil Approved Phase 2 120014-06-4 3152
34
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
35
Dabigatran Investigational Phase 2 211914-51-1
36 HIV Protease Inhibitors Phase 2
37
protease inhibitors Phase 2
38 Antithrombins Phase 2
39 Anticoagulants Phase 2
40 Antithrombin III Phase 2
41 Serine Proteinase Inhibitors Phase 2
42 Nootropic Agents Phase 2
43 Cholinesterase Inhibitors Phase 2
44 Cholinergic Agents Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Efficacy of Pain Treatment on Depression in Patients With Dementia Completed NCT02267057 Phase 4 Paracetamol;Buprenorphine;Paracetamol placebo;Buprenorphine placebo
2 Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function Recruiting NCT03082014 Phase 3 Amlodipine;Losartan;Atenolol
3 Safety Study of Dabigatran in CADASIL Unknown status NCT01361763 Phase 2 Dabigatran;Antiplatelets
4 The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment Completed NCT00103948 Phase 2 Aricept
5 Secondary Prevention of Stroke Through Non-drug Therapeutic Weight Reduction Unknown status NCT01721538 Not Applicable
6 Generation of a Cellular Model of CADASIL From Skin Fibroblasts Unknown status NCT02032225
7 Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Unknown status NCT02071784
8 Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control Studies Unknown status NCT02196532
9 Identification of Biomarkers Sensitive to Disease Progression in Patients With Mild Cognitive Impairment Completed NCT01425957 Not Applicable
10 Research Study on Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Completed NCT01114815
11 The Silent Cortical Infarcts in the Cerebral Amyloid Angiopathy: Is There a Link With Subarachnoid Hemorrhage? Completed NCT02837354
12 Impact of tDCS on Cerebral Autoregulation Completed NCT01865604 Not Applicable
13 Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysis Completed NCT01928212
14 Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study Recruiting NCT03724136 Not Applicable
15 Neurologic Stem Cell Treatment Study Recruiting NCT02795052 Not Applicable
16 CADASIL Disease Discovery Active, not recruiting NCT02821780

Search NIH Clinical Center for Binswanger's Disease

Genetic Tests for Binswanger's Disease

Anatomical Context for Binswanger's Disease

MalaCards organs/tissues related to Binswanger's Disease:

42
Brain, Skin, Testes, Endothelial, Smooth Muscle, Globus Pallidus, Amygdala

Publications for Binswanger's Disease

Articles related to Binswanger's Disease:

(show top 50) (show all 339)
# Title Authors Year
1
Binswanger's disease: Biomarkers in the inflammatory form of vascular cognitive impairment and dementia. ( 28902409 )
2017
2
Multi-infarct dementia of Swedish type is caused by a 3'UTR mutation of COL4A1. ( 28369186 )
2017
3
Multi-Infarct Dementia: A Historical Perspective. ( 28626470 )
2017
4
Multi-infarct dementia and Alzheimer disease, contribution of cerebral circulation ultrasonography to pathogenesis and differential diagnosis. Value of microembolisation. ( 27179577 )
2016
5
Ekbom syndrome occurring with multi infarct dementia. ( 26023627 )
2015
6
Comparison of medial temporal measures between Binswanger's disease and Alzheimer's disease. ( 24466084 )
2014
7
Binswanger's disease: toward a diagnosis agreement and therapeutic approach. ( 25201523 )
2014
8
MRI features of Binswanger's disease predict prognosis and associated pathology. ( 25493272 )
2014
9
Cognitive profiles in patients with multi-infarct dementia: an omani study. ( 25202321 )
2014
10
Effects of acupuncture on declined cerebral blood flow, impaired mitochondrial respiratory function and oxidative stress in multi-infarct dementia rats. ( 24361538 )
2013
11
Morphometric characterization of Binswanger's disease: comparison with Alzheimer's disease. ( 21708443 )
2012
12
Varicella zoster virus vasculopathy: a treatable form of rapidly progressive multi-infarct dementia after 2 years' duration. ( 22935406 )
2012
13
Vascular cognitive impairment in small vessel disease: clinical and neuropsychological features of lacunar state and Binswanger's disease. ( 21239411 )
2011
14
Effects of acupuncture on glycometabolic enzymes in multi-infarct dementia rats. ( 21279683 )
2011
15
Binswanger's disease and quantitative fractional anisotropy. ( 19547805 )
2009
16
Lateralization of hippocampal nitric oxide mediator system in people with Alzheimer disease, multi-infarct dementia and schizophrenia. ( 18647632 )
2008
17
Different responses to rivastigmine in subcortical vascular dementia and multi-infarct dementia. ( 18184948 )
2008
18
The corpus callosum in Binswanger's disease: A quantitative fractional anisotropy analysis. ( 29213585 )
2008
19
Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease. ( 18617735 )
2008
20
Stroke and multi-infarct dementia as presenting symptoms of giant cell arteritis: report of 7 cases and review of the literature. ( 19011505 )
2008
21
Hereditary multi-infarct dementia of the Swedish type is a novel disorder different from NOTCH3 causing CADASIL. ( 17235124 )
2007
22
Binswanger's disease. ( 17694788 )
2007
23
Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease. ( 17403574 )
2007
24
Protective effects of Nicotiflorin on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats. ( 17448528 )
2007
25
Small artery dementia in Japan: radiological differences between CADASIL, leukoaraiosis and Binswanger's disease. ( 16391479 )
2006
26
Acupuncture improved cognitive impairment caused by multi-infarct dementia in rats. ( 16181648 )
2005
27
From Binswanger's disease to leuokoaraiosis: what we have learned about subcortical vascular dementia. ( 15595361 )
2004
28
Cerebral blood flow patterns in Binswanger's disease: a SPECT study using three-dimensional stereotactic surface projections. ( 15140610 )
2004
29
Pathology of the cerebral artery in Binswanger's disease in the aged: observation by serial sections and morphometry of the cerebral arteries. ( 15068169 )
2004
30
Topographical and cytopathological lesion analysis of the white matter in Binswanger's disease brains. ( 15088098 )
2004
31
Questions & answers. We've been told that my wife has multi-infarct dementia and that the new drug memantine may help. How is her condition different from Alzheimer's disease, and what could memantine do for her? ( 15044129 )
2004
32
Cerebral microbleeds in Binswanger's disease: a gradient-echo T2*-weighted magnetic resonance imaging study. ( 12672544 )
2003
33
Binswanger's disease: its association with hypertension and obstructive sleep apnea. ( 12858817 )
2003
34
-174 G/C interleukin-6 gene polymorphism and increased risk of multi-infarct dementia: a case-control study. ( 12086705 )
2002
35
Increased blood-brain barrier permeability in white matter lesions of Binswanger's disease evaluated by contrast-enhanced MRI. ( 12053125 )
2002
36
A case of primary cutaneous histoplasmosis in a patient with diabetes and multi-infarct dementia. ( 12532047 )
2002
37
Jian Nao Ning for treatment of memory impairment in patients with mild or moderate multi-infarct dementia. ( 16579082 )
2002
38
Blood pressure variability in Binswanger's disease and isolated lacunar infarction. ( 11306773 )
2001
39
Increasing in situ nick end labeling of oligodendrocytes in white matter of patients with Binswanger's disease. ( 17903801 )
2001
40
A double dissociation between accuracy and time of execution on attentional tasks in Alzheimer's disease and multi-infarct dementia. ( 11287373 )
2001
41
Inflammatory markers in Alzheimer's disease and multi-infarct dementia. ( 11589916 )
2001
42
The factor structure in the cognitive battery of the structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia, and dementias of other aetiology. ( 11768378 )
2001
43
Thrombin and antithrombin in Binswanger's disease. ( 11065234 )
2000
44
Binswanger's disease is not a single entity. ( 11441570 )
2000
45
Vascular cell components of the medullary arteries in Binswanger's disease brains: a morphometric and immunoelectron microscopic study. ( 10926944 )
2000
46
Binswanger's disease: an ongoing controversy. ( 10956563 )
2000
47
Efficacy and safety of nimodipine in subcortical vascular dementia: a subgroup analysis of the Scandinavian Multi-Infarct Dementia Trial. ( 10831773 )
2000
48
Cerebral blood flow and glucose metabolism in multi-infarct-dementia related to primary antiphospholipid antibody syndrome. ( 10866105 )
2000
49
The Scandinavian Multi-Infarct Dementia Trial: a double-blind, placebo-controlled trial on nimodipine in multi-infarct dementia. ( 10831772 )
2000
50
A promising approach to the treatment of multi-infarct dementia. ( 10867212 )
2000

Variations for Binswanger's Disease

Expression for Binswanger's Disease

Search GEO for disease gene expression data for Binswanger's Disease.

Pathways for Binswanger's Disease

Pathways related to Binswanger's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.7 APOE APP GFAP MAPT NOTCH3 SYP
2 11.34 APOE APP MAPT
3 11.11 APOE APP MAPT
4 10.79 APOE APP MAPT

GO Terms for Binswanger's Disease

Cellular components related to Binswanger's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.95 ACHE ACTC1 APOE APP CHGA CRH
2 neuron projection GO:0043005 9.78 APP MAPT SYP VIP
3 neuronal cell body GO:0043025 9.76 APOE CRH MAPT SST
4 synaptic cleft GO:0043083 9.43 ACHE APOE
5 cell body GO:0044297 9.43 ACTC1 GFAP MAPT
6 astrocyte projection GO:0097449 9.37 APP GFAP
7 neuromuscular junction GO:0031594 9.33 ACHE APP SYP
8 glial cell projection GO:0097386 9.32 GFAP MAPT
9 extracellular region GO:0005576 9.32 ACHE APOE APP CHGA CRH MAPT
10 main axon GO:0044304 8.96 APP MAPT

Biological processes related to Binswanger's Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.86 ACTC1 APP CRH PLP1
2 negative regulation of gene expression GO:0010629 9.62 APOE APP CRH MAPT
3 artery morphogenesis GO:0048844 9.57 APOE NOTCH3
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.55 APP SYP
5 response to lead ion GO:0010288 9.54 APP MAPT
6 regulation of neuronal synaptic plasticity GO:0048168 9.52 APOE SYP
7 regulation of NMDA receptor activity GO:2000310 9.51 APP CRH
8 astrocyte development GO:0014002 9.49 GFAP PLP1
9 locomotory exploration behavior GO:0035641 9.48 APOE CRH
10 amyloid precursor protein metabolic process GO:0042982 9.46 ACHE APOE
11 astrocyte activation GO:0048143 9.43 APP MAPT
12 learning or memory GO:0007611 9.43 APP CRH VIP
13 negative regulation of long-term synaptic potentiation GO:1900272 9.4 APOE APP
14 amyloid fibril formation GO:1990000 9.37 APP MAPT
15 hormone-mediated apoptotic signaling pathway GO:0008628 9.16 CRH SST
16 positive regulation of amyloid fibril formation GO:1905908 8.96 APOE APP
17 axon development GO:0061564 8.8 GFAP MAPT PLP1

Molecular functions related to Binswanger's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 APOE APP GFAP MAPT NOTCH3 SYP
2 hormone activity GO:0005179 9.33 CRH SST VIP
3 neuropeptide hormone activity GO:0005184 9.26 CRH VIP
4 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Binswanger's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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