MCID: BNS003
MIFTS: 47

Binswanger's Disease

Categories: Rare diseases

Aliases & Classifications for Binswanger's Disease

MalaCards integrated aliases for Binswanger's Disease:

Name: Binswanger's Disease 54 55
Multi-Infarct Dementia 54 74
Dementia Multi-Infarct 54 56
Binswanger Disease 56 74
Dementia - Multi-Infarct 55

Classifications:



External Ids:

Summaries for Binswanger's Disease

NINDS : 55 Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists callexecutive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis.  

MalaCards based summary : Binswanger's Disease, also known as multi-infarct dementia, is related to subcortical arteriosclerotic encephalopathy and hydrocephalus, normal-pressure. An important gene associated with Binswanger's Disease is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Reelin Pathway (Cajal-Retzius cells). The drugs Buprenorphine and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and skin, and related phenotypes are behavior/neurological and growth/size/body region

NIH Rare Diseases : 54 Binswanger's disease is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. Most affected people experience progressive memory loss and deterioration of intellectual abilities (dementia); urinary urgency or incontinence; and an abnormally slow, unsteady gait (style of walking). While there is no cure, the progression of Binswanger's disease can be slowed with healthy lifestyle choices. Treatment is based on the signs and symptoms present in each person.

Wikipedia : 77 Binswanger''s disease, also known as subcortical leukoencephalopathy and subcortical arteriosclerotic... more...

Related Diseases for Binswanger's Disease

Diseases related to Binswanger's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 187, show less)
# Related Disease Score Top Affiliating Genes
1 subcortical arteriosclerotic encephalopathy 32.7 GFAP VIP
2 hydrocephalus, normal-pressure 30.3 APOE MAPT
3 dementia 29.8 ACHE APOE APP MAPT NOTCH3
4 cerebral amyloid angiopathy, cst3-related 29.6 APOE APP MAPT
5 vascular dementia 29.3 ACHE APOE APP MAPT NOTCH3
6 hydrocephalus 29.3 APOE APP GFAP MAPT SYP
7 alzheimer disease 28.9 ACHE APOE APP CRH GFAP MAPT
8 dementia - subcortical 11.1
9 encephalopathy 10.7
10 cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 10.6
11 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 10.6
12 glomus tumor 10.5 ACTC1 SYP
13 functional colonic disease 10.5 SST SYP
14 ureter small cell carcinoma 10.5 CHGA SYP
15 esophageal neuroendocrine tumor 10.5 CHGA SYP
16 duodenal gastrinoma 10.4 CHGA SST
17 urinary bladder small cell neuroendocrine carcinoma 10.4 CHGA SYP
18 ovarian large-cell neuroendocrine carcinoma 10.4 CHGA SYP
19 auditory system cancer 10.4 CHGA SYP
20 acinar cell cystadenocarcinoma 10.4 CHGA SYP
21 peritoneal serous adenocarcinoma 10.4 CHGA SYP
22 primary hepatic neuroendocrine carcinoma 10.4 CHGA SYP
23 small cell carcinoma of the bladder 10.4 CHGA SYP
24 pulmonary large cell neuroendocrine carcinoma 10.4 CHGA SYP
25 papilloma of choroid plexus 10.4 GFAP SYP
26 malignant glandular tumor of peripheral nerve sheath 10.4 SST SYP
27 pineoblastoma 10.4 GFAP SYP
28 gallbladder small cell carcinoma 10.4 CHGA SYP
29 atypical follicular adenoma 10.4 CHGA SYP
30 olfactory groove meningioma 10.4 CHGA SYP
31 pancreatic somatostatinoma 10.4 SST SYP
32 cauda equina neoplasm 10.4 CHGA SYP
33 gastrointestinal neuroendocrine benign tumor 10.4 CHGA SST
34 pancreatic serous cystadenoma 10.4 CHGA SYP
35 conventional angiosarcoma 10.4 CHGA SYP
36 gastric neuroendocrine neoplasm 10.4 CHGA SST
37 myofibromatosis, infantile, 1 10.4 ACTC1 NOTCH3
38 desmoplastic infantile ganglioglioma 10.4 GFAP SYP
39 extraventricular neurocytoma 10.4 GFAP SYP
40 olfactory nerve neoplasm 10.4 CHGA SYP
41 anaplastic ganglioglioma 10.4 ACTC1 GFAP
42 pancreatic endocrine carcinoma 10.4 SST SYP
43 lung combined type small cell carcinoma 10.4 GFAP SYP
44 cutaneous leiomyosarcoma 10.4 ACTC1 GFAP
45 parachordoma 10.4 ACTC1 GFAP
46 syringocystadenoma papilliferum 10.4 ACTC1 GFAP
47 nodular ganglioneuroblastoma 10.4 CHGA SYP
48 non-langerhans-cell histiocytosis 10.4 ACTC1 SST
49 central nervous system primitive neuroectodermal neoplasm 10.4 GFAP SYP
50 insulinomatosis and diabetes mellitus 10.4 CHGA SST
51 clear cell ependymoma 10.4 GFAP SYP
52 chiari malformation 10.4 GFAP SYP
53 dysembryoplastic neuroepithelial tumor 10.3 GFAP SYP
54 cerebral neuroblastoma 10.3 GFAP SYP
55 glycogen-rich clear cell breast carcinoma 10.3 ACTC1 SYP
56 subependymal glioma 10.3 GFAP SYP
57 astroblastoma 10.3 GFAP SYP
58 pulmonary sclerosing hemangioma 10.3 CHGA SYP
59 cerebral ventricle cancer 10.3 GFAP SYP
60 clear cell meningioma 10.3 CHGA GFAP
61 sclerosing hemangioma 10.3 CHGA SYP
62 horseshoe kidney 10.3 ACTC1 CHGA SYP
63 granulosa cell tumor of the ovary 10.3 ACTC1 CHGA SYP
64 pineal gland cancer 10.3 GFAP SYP
65 melanotic neuroectodermal tumor 10.3 GFAP SYP
66 gastric small cell carcinoma 10.3 CHGA SYP
67 gastrointestinal neuroendocrine tumor 10.3 CHGA SST SYP
68 benign ependymoma 10.3 GFAP SYP
69 neuroendocrine tumor 10.3 CHGA SST SYP
70 pancreatoblastoma 10.3 CHGA SST SYP
71 carcinoid tumors, intestinal 10.3 CHGA SST SYP
72 respiratory system benign neoplasm 10.3 CHGA SYP
73 carcinoid syndrome 10.3 CHGA SST SYP
74 obstructive hydrocephalus 10.3 GFAP SYP
75 malignant pheochromocytoma 10.3 CHGA SST SYP
76 mixed ductal-endocrine carcinoma 10.3 CHGA SST SYP
77 hemangioma 10.3 ACTC1 CHGA SYP
78 endocrine organ benign neoplasm 10.3 CHGA SST SYP
79 perivascular epithelioid cell tumor 10.3 ACTC1 SYP
80 merkel cell carcinoma 10.3 CHGA SST SYP
81 medulloepithelioma 10.3 GFAP SYP
82 paraganglioma 10.3 CHGA SST SYP
83 hypoganglionosis 10.3 ACHE SYP
84 wdha syndrome 10.3 SST VIP
85 angiocentric glioma 10.3 ACTC1 GFAP SYP
86 anterior cranial fossa meningioma 10.3 CHGA SYP
87 cellular ependymoma 10.3 CHGA GFAP SYP
88 chordoid meningioma 10.3 CHGA GFAP SYP
89 pineocytoma 10.3 CHGA GFAP SYP
90 subependymoma 10.3 CHGA GFAP SYP
91 pleomorphic xanthoastrocytoma 10.3 CHGA GFAP SYP
92 tanycytic ependymoma 10.3 CHGA GFAP SYP
93 papillary ependymoma 10.3 CHGA GFAP SYP
94 central neurocytoma 10.3 CHGA GFAP SYP
95 cerebellar liponeurocytoma 10.2 CHGA GFAP SYP
96 senile plaque formation 10.2 APOE APP
97 small cell cancer of the lung 10.2 CHGA SST SYP
98 postgastrectomy syndrome 10.2 SST VIP
99 ganglioglioma 10.2 CHGA GFAP SYP
100 spinocerebellar degeneration 10.2 CRH SST
101 teratoma 10.2 ACTC1 GFAP SYP
102 alzheimer's disease 1 10.2 APOE APP
103 cerebral hemorrhage 10.2 APP GFAP
104 gastrointestinal stromal tumor 10.2 ACTC1 CHGA SYP
105 gastric squamous cell carcinoma 10.2 CHGA SYP
106 gangliocytoma 10.2 CRH SYP
107 allergic encephalomyelitis 10.2 CRH PLP1
108 benign familial neonatal epilepsy 10.2 CRH GFAP
109 gait apraxia 10.2 APOE APP
110 meningioma, familial 10.2 GFAP SST SYP
111 urethral benign neoplasm 10.2 APP CHGA
112 anaplastic ependymoma 10.2 GFAP SYP
113 cerebral degeneration 10.2 GFAP NOTCH3 PLP1
114 autonomic nervous system benign neoplasm 10.2 CHGA SYP VIP
115 atypical choroid plexus papilloma 10.2 APP NOTCH3 SYP
116 colonic pseudo-obstruction 10.1 ACHE SST SYP
117 glucagonoma 10.1 CHGA SST VIP
118 vipoma 10.1 CHGA SST VIP
119 somatostatinoma 10.1 CHGA SST VIP
120 gastrinoma 10.1 CHGA SST VIP
121 islet cell tumor 10.1 CHGA SST VIP
122 nelson syndrome 10.1 CRH SST
123 depression 10.1
124 pulmonary blastoma 10.1 CHGA SYP
125 childhood oligodendroglioma 10.1 GFAP SYP
126 ectopic cushing syndrome 10.1 CRH SST SYP
127 adrenocortical carcinoma, hereditary 10.1 CHGA CRH SYP
128 communicating hydrocephalus 10.1 APOE MAPT
129 peripheral nervous system neoplasm 10.0 APP SYP VIP
130 simultanagnosia 10.0 APOE MAPT
131 postencephalitic parkinson disease 10.0 MAPT SYP
132 posterior cortical atrophy 10.0 APOE MAPT
133 pancreatic cholera 10.0 SST VIP
134 multiple endocrine neoplasia, type i 10.0 CHGA SST SYP VIP
135 endocrine gland cancer 10.0 CHGA SST SYP VIP
136 congenital hydrocephalus 10.0
137 non-functioning pancreatic endocrine tumor 10.0 CHGA SYP
138 toxic encephalopathy 10.0 ACHE APP GFAP
139 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.0
140 stroke, ischemic 10.0
141 cognitive impairment with or without cerebellar ataxia 10.0
142 sleep apnea 10.0
143 cerebral atherosclerosis 10.0
144 porphyria 10.0
145 antiphospholipid syndrome 10.0
146 acute porphyria 10.0
147 mood disorder 10.0
148 ganglioneuroma 10.0 CHGA GFAP SYP VIP
149 semantic dementia 10.0 APOE MAPT
150 cell type benign neoplasm 9.9 CHGA CRH SST SYP
151 restless legs syndrome 1 9.9
152 alcohol dependence 9.9
153 guillain-barre syndrome, familial 9.9
154 systemic lupus erythematosus 9.9
155 platelet membrane fluidity 9.9
156 schizophrenia 9.9
157 temporal arteritis 9.9
158 lymphoproliferative syndrome, x-linked, 1 9.9
159 lymphoproliferative syndrome 9.9
160 vertebrobasilar insufficiency 9.9
161 histoplasmosis 9.9
162 ischemia 9.9
163 chickenpox 9.9
164 lupus erythematosus 9.9
165 irritable bowel syndrome 9.9 CHGA CRH VIP
166 hirschsprung disease 1 9.9 ACHE SYP VIP
167 kluver-bucy syndrome 9.9 APP MAPT
168 wernicke encephalopathy 9.9 GFAP MAPT
169 pituitary carcinoma 9.9 CHGA CRH GFAP SST
170 brain injury 9.8 APOE GFAP MAPT
171 kohlschutter-tonz syndrome 9.8 APOE APP MAPT
172 alzheimer disease mitochondrial 9.8 APOE APP MAPT
173 leukoencephalopathy, hereditary diffuse, with spheroids 9.8 APP GFAP MAPT
174 alzheimer disease 2 9.8 APOE APP MAPT
175 aphasia 9.8 APOE APP MAPT
176 inclusion body myositis 9.8 APOE APP MAPT
177 pick disease of brain 9.6 APOE APP CHGA MAPT
178 pheochromocytoma 9.6 CHGA CRH SST SYP VIP
179 amyotrophic lateral sclerosis 1 9.6 APP GFAP MAPT SYP
180 supranuclear palsy, progressive, 1 9.5 ACHE APOE APP MAPT
181 frontotemporal dementia 9.5 ACHE APOE APP MAPT
182 parkinson disease, late-onset 9.4 ACHE APOE APP MAPT
183 disease of mental health 9.4 APOE APP CRH MAPT
184 central nervous system disease 9.4 APOE APP GFAP MAPT PLP1
185 dementia, lewy body 9.4 ACHE APOE APP MAPT SYP
186 cerebrovascular disease 9.3 ACHE APOE APP MAPT NOTCH3
187 nervous system disease 9.1 ACHE APOE APP GFAP MAPT SYP

Graphical network of the top 20 diseases related to Binswanger's Disease:



Diseases related to Binswanger's Disease

Symptoms & Phenotypes for Binswanger's Disease

MGI Mouse Phenotypes related to Binswanger's Disease:

47 (showing 13, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.26 ACHE APOE APP CRH GFAP MAPT
2 growth/size/body region MP:0005378 10.26 ACHE ACTC1 APOE APP CHGA CRH
3 homeostasis/metabolism MP:0005376 10.23 ACHE ACTC1 APOE APP CHGA CRH
4 mortality/aging MP:0010768 10.18 ACHE ACTC1 APOE APP CHGA GFAP
5 cardiovascular system MP:0005385 10.16 ACTC1 APOE APP CHGA GFAP MAPT
6 cellular MP:0005384 10.15 ACTC1 APOE APP CRH GFAP MAPT
7 nervous system MP:0003631 10.1 ACHE APOE APP CHGA CRH GFAP
8 immune system MP:0005387 10.09 APOE APP CRH GFAP MAPT NOTCH3
9 muscle MP:0005369 10.02 ACHE ACTC1 APOE APP CHGA GFAP
10 normal MP:0002873 9.81 ACTC1 APP CRH GFAP MAPT NOTCH3
11 no phenotypic analysis MP:0003012 9.8 ACHE APOE APP CHGA CRH MAPT
12 reproductive system MP:0005389 9.5 ACHE APOE APP CHGA NOTCH3 PLP1
13 vision/eye MP:0005391 9.17 ACHE APOE GFAP MAPT NOTCH3 PLP1

Drugs & Therapeutics for Binswanger's Disease

Drugs for Binswanger's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 44, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 644073 40400
2
Acetaminophen Approved Phase 4 103-90-2 1983
3 Analgesics Phase 4
4 Analgesics, Non-Narcotic Phase 4
5 Peripheral Nervous System Agents Phase 4,Phase 3
6 Antipyretics Phase 4
7 Analgesics, Opioid Phase 4
8 Central Nervous System Depressants Phase 4
9 Narcotic Antagonists Phase 4
10 Narcotics Phase 4
11
Losartan Approved Phase 3 114798-26-4 3961
12
Atenolol Approved Phase 3 29122-68-7 2249
13
Amlodipine Approved Phase 3 88150-42-9 2162
14
Angiotensin II Approved, Investigational Phase 3 11128-99-7, 68521-88-0, 4474-91-3 172198
15
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
16 Neurotransmitter Agents Phase 3,Phase 2
17 Angiotensin Receptor Antagonists Phase 3
18 Calcium, Dietary Phase 3
19 Adrenergic Antagonists Phase 3
20 Anti-Arrhythmia Agents Phase 3
21 Sympatholytics Phase 3
22 Vasodilator Agents Phase 3
23 Antihypertensive Agents Phase 3
24 Hormones Phase 3
25 Giapreza Phase 3
26 Adrenergic beta-1 Receptor Antagonists Phase 3
27 Adrenergic Agents Phase 3
28 Angiotensinogen Phase 3
29 calcium channel blockers Phase 3
30 Adrenergic beta-Antagonists Phase 3
31 Angiotensin II Type 1 Receptor Blockers Phase 3
32 Autonomic Agents Phase 3
33
Donepezil Approved Phase 2 120014-06-4 3152
34
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
35
Dabigatran Investigational Phase 2 211914-51-1
36 Anticoagulants Phase 2
37
protease inhibitors Phase 2
38 Antithrombin III Phase 2
39 HIV Protease Inhibitors Phase 2
40 Serine Proteinase Inhibitors Phase 2
41 Antithrombins Phase 2
42 Cholinesterase Inhibitors Phase 2
43 Nootropic Agents Phase 2
44 Cholinergic Agents Phase 2

Interventional clinical trials:

(showing 16, show less)
# Name Status NCT ID Phase Drugs
1 Efficacy of Pain Treatment on Depression in Patients With Dementia Completed NCT02267057 Phase 4 Paracetamol;Buprenorphine;Paracetamol placebo;Buprenorphine placebo
2 Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function Recruiting NCT03082014 Phase 3 Amlodipine;Losartan;Atenolol
3 Safety Study of Dabigatran in CADASIL Unknown status NCT01361763 Phase 2 Dabigatran;Antiplatelets
4 The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment Completed NCT00103948 Phase 2 Aricept
5 Secondary Prevention of Stroke Through Non-drug Therapeutic Weight Reduction Unknown status NCT01721538 Not Applicable
6 Generation of a Cellular Model of CADASIL From Skin Fibroblasts Unknown status NCT02032225
7 Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Unknown status NCT02071784
8 Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control Studies Unknown status NCT02196532
9 Identification of Biomarkers Sensitive to Disease Progression in Patients With Mild Cognitive Impairment Completed NCT01425957 Not Applicable
10 Research Study on Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Completed NCT01114815
11 The Silent Cortical Infarcts in the Cerebral Amyloid Angiopathy: Is There a Link With Subarachnoid Hemorrhage? Completed NCT02837354
12 Impact of tDCS on Cerebral Autoregulation Completed NCT01865604 Not Applicable
13 Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysis Completed NCT01928212
14 Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study Recruiting NCT03724136 Not Applicable
15 Neurologic Stem Cell Treatment Study Recruiting NCT02795052 Not Applicable
16 CADASIL Disease Discovery Active, not recruiting NCT02821780

Search NIH Clinical Center for Binswanger's Disease

Genetic Tests for Binswanger's Disease

Anatomical Context for Binswanger's Disease

MalaCards organs/tissues related to Binswanger's Disease:

42
Brain, Lung, Skin, Colon, Testes, Endothelial, Smooth Muscle

Publications for Binswanger's Disease

Articles related to Binswanger's Disease:

(showing 340, show less)
# Title Authors Year
1
X-Linked Lymphoproliferative Syndrome Presenting as Adult-Onset Multi-Infarct Dementia. ( 30990878 )
2019
2
Binswanger's disease: biomarkers in the inflammatory form of vascular cognitive impairment and dementia. ( 28902409 )
2018
3
Multi-infarct dementia of Swedish type is caused by a 3'UTR mutation of COL4A1. ( 28369186 )
2017
4
Multi-Infarct Dementia: A Historical Perspective. ( 28626470 )
2017
5
Multi-infarct dementia and Alzheimer disease, contribution of cerebral circulation ultrasonography to pathogenesis and differential diagnosis. Value of microembolisation. ( 27179577 )
2016
6
Ekbom syndrome occurring with multi infarct dementia. ( 26023627 )
2015
7
Comparison of medial temporal measures between Binswanger's disease and Alzheimer's disease. ( 24466084 )
2014
8
Binswanger's disease: toward a diagnosis agreement and therapeutic approach. ( 25201523 )
2014
9
MRI features of Binswanger's disease predict prognosis and associated pathology. ( 25493272 )
2014
10
Effects of acupuncture on declined cerebral blood flow, impaired mitochondrial respiratory function and oxidative stress in multi-infarct dementia rats. ( 24361538 )
2014
11
Cognitive profiles in patients with multi-infarct dementia: an omani study. ( 25202321 )
2014
12
Morphometric characterization of Binswanger's disease: comparison with Alzheimer's disease. ( 21708443 )
2012
13
Varicella zoster virus vasculopathy: a treatable form of rapidly progressive multi-infarct dementia after 2 years' duration. ( 22935406 )
2012
14
Vascular cognitive impairment in small vessel disease: clinical and neuropsychological features of lacunar state and Binswanger's disease. ( 21239411 )
2011
15
Effects of acupuncture on glycometabolic enzymes in multi-infarct dementia rats. ( 21279683 )
2011
16
Binswanger's disease and quantitative fractional anisotropy. ( 19547805 )
2009
17
Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease. ( 18617735 )
2008
18
The corpus callosum in Binswanger's disease: A quantitative fractional anisotropy analysis. ( 29213585 )
2008
19
Different responses to rivastigmine in subcortical vascular dementia and multi-infarct dementia. ( 18184948 )
2008
20
Lateralization of hippocampal nitric oxide mediator system in people with Alzheimer disease, multi-infarct dementia and schizophrenia. ( 18647632 )
2008
21
Stroke and multi-infarct dementia as presenting symptoms of giant cell arteritis: report of 7 cases and review of the literature. ( 19011505 )
2008
22
Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease. ( 17403574 )
2007
23
Binswanger's disease. ( 17694788 )
2007
24
Hereditary multi-infarct dementia of the Swedish type is a novel disorder different from NOTCH3 causing CADASIL. ( 17235124 )
2007
25
Protective effects of Nicotiflorin on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats. ( 17448528 )
2007
26
Small artery dementia in Japan: radiological differences between CADASIL, leukoaraiosis and Binswanger's disease. ( 16391479 )
2006
27
Acupuncture improved cognitive impairment caused by multi-infarct dementia in rats. ( 16181648 )
2005
28
Pathology of the cerebral artery in Binswanger's disease in the aged: observation by serial sections and morphometry of the cerebral arteries. ( 15068169 )
2004
29
Topographical and cytopathological lesion analysis of the white matter in Binswanger's disease brains. ( 15088098 )
2004
30
Cerebral blood flow patterns in Binswanger's disease: a SPECT study using three-dimensional stereotactic surface projections. ( 15140610 )
2004
31
From Binswanger's disease to leuokoaraiosis: what we have learned about subcortical vascular dementia. ( 15595361 )
2004
32
Questions & answers. We've been told that my wife has multi-infarct dementia and that the new drug memantine may help. How is her condition different from Alzheimer's disease, and what could memantine do for her? ( 15044129 )
2004
33
Cerebral microbleeds in Binswanger's disease: a gradient-echo T2*-weighted magnetic resonance imaging study. ( 12672544 )
2003
34
Binswanger's disease: its association with hypertension and obstructive sleep apnea. ( 12858817 )
2003
35
Increased blood-brain barrier permeability in white matter lesions of Binswanger's disease evaluated by contrast-enhanced MRI. ( 12053125 )
2002
36
A case of primary cutaneous histoplasmosis in a patient with diabetes and multi-infarct dementia. ( 12532047 )
2002
37
-174 G/C interleukin-6 gene polymorphism and increased risk of multi-infarct dementia: a case-control study. ( 12086705 )
2002
38
Jian Nao Ning for treatment of memory impairment in patients with mild or moderate multi-infarct dementia. ( 16579082 )
2002
39
Blood pressure variability in Binswanger's disease and isolated lacunar infarction. ( 11306773 )
2001
40
Increasing in situ nick end labeling of oligodendrocytes in white matter of patients with Binswanger's disease. ( 17903801 )
2001
41
A double dissociation between accuracy and time of execution on attentional tasks in Alzheimer's disease and multi-infarct dementia. ( 11287373 )
2001
42
Inflammatory markers in Alzheimer's disease and multi-infarct dementia. ( 11589916 )
2001
43
The factor structure in the cognitive battery of the structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia, and dementias of other aetiology. ( 11768378 )
2001
44
Vascular cell components of the medullary arteries in Binswanger's disease brains: a morphometric and immunoelectron microscopic study. ( 10926944 )
2000
45
Binswanger's disease: an ongoing controversy. ( 10956563 )
2000
46
Thrombin and antithrombin in Binswanger's disease. ( 11065234 )
2000
47
Binswanger's disease is not a single entity. ( 11441570 )
2000
48
Efficacy and safety of nimodipine in subcortical vascular dementia: a subgroup analysis of the Scandinavian Multi-Infarct Dementia Trial. ( 10831773 )
2000
49
Cerebral blood flow and glucose metabolism in multi-infarct-dementia related to primary antiphospholipid antibody syndrome. ( 10866105 )
2000
50
The Scandinavian Multi-Infarct Dementia Trial: a double-blind, placebo-controlled trial on nimodipine in multi-infarct dementia. ( 10831772 )
2000
51
A promising approach to the treatment of multi-infarct dementia. ( 10867212 )
2000
52
Effects of antithrombin on Binswanger's disease with antiphospholipid antibody syndrome. ( 9932966 )
1999
53
Increased coagulatory activity in subcortical arteriosclerotic encephalopathy (Binswanger's disease) ( 9987717 )
1999
54
Rheologic determinant changes of erythrocytes in Binswanger's disease. ( 10063717 )
1999
55
Magnetization transfer ratio in cerebral white matter lesions of Binswanger's disease. ( 10475100 )
1999
56
A study of platelet organelles and membrane glycoprotein in patients with Binswanger's disease. ( 11717951 )
1999
57
Change of tumor necrosis factor-alpha levels in patients with Binswanger's disease. ( 12899375 )
1999
58
Cytopathological alterations and therapeutic approaches in Binswanger's disease. ( 19519655 )
1999
59
The effect of dehydroepiandrosterone sulfate administration to patients with multi-infarct dementia. ( 10064172 )
1999
60
Blood-brain barrier dysfunction in Binswanger's disease; an immunohistochemical study. ( 9452825 )
1998
61
Binswanger's disease. A rare cause of dementia in elderly persons. ( 9591403 )
1998
62
Giant cell arteritis complicated by multi-infarct dementia. ( 19078294 )
1998
63
The angiopathy of subcortical arteriosclerotic encephalopathy (Binswanger's disease): immunohistochemical studies using markers for components of extracellular matrix, smooth muscle actin and endothelial cells. ( 9083552 )
1997
64
Auditory P300, CT scans and cognitive state in Binswanger's disease. ( 9170551 )
1997
65
Alterations in glia and axons in the brains of Binswanger's disease patients. ( 9227695 )
1997
66
Different manifestations of circadian rhythms in senile dementia of Alzheimer's type and multi-infarct dementia. ( 8983038 )
1997
67
A multicenter randomized double-blind study on the efficacy and safety of nicergoline in patients with multi-infarct dementia. ( 8997547 )
1997
68
Clinical-neuropathologic findings in multi-infarct dementia: a report of six autopsied cases. ( 9065545 )
1997
69
Geriatrics photo quiz. Multi-infarct dementia. ( 9152214 )
1997
70
Apolipoprotein E genotypes and serum lipid levels in Alzheimer's disease and multi-infarct dementia. ( 9152721 )
1997
71
Regional atrophy of the corpus callosum in subjects with Alzheimer's disease and multi-infarct dementia. ( 9204509 )
1997
72
Clinical-neuropathologic findings in multi-infarct dementia: a report of six autopsied cases. ( 9409393 )
1997
73
Clinical-neuropathologic findings in multi-infarct dementia: a report of six autopsied cases. ( 9409394 )
1997
74
Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. ( 23195239 )
1997
75
Antiphospholipid antibodies and Binswanger's disease. ( 8559412 )
1996
76
Antiphospholipid antibodies and Binswanger's disease. ( 8559413 )
1996
77
Multimodal evoked potentials in Alzheimer's disease and Binswanger's disease. ( 8679063 )
1996
78
From UBOs to Binswanger's disease. Impact of magnetic resonance imaging on vascular dementia research. ( 8711785 )
1996
79
Visual and somatosensory evoked potentials in Parkinson's and Binswanger's disease. ( 8788083 )
1996
80
The first Italian report on "Binswanger's disease". ( 8933231 )
1996
81
The role of endothelin-1 in Binswanger's disease. ( 8940785 )
1996
82
Somatostatin, its molecular forms and monoaminergic transmitter metabolites in Binswanger's disease. Neurochemical-neuropathological considerations. ( 9117548 )
1996
83
The apolipoprotein E gene in Binswanger's disease and vascular dementia. ( 9147873 )
1996
84
Language comprehension profiles in Alzheimer's disease, multi-infarct dementia, and frontotemporal degeneration. ( 8710075 )
1996
85
Amino acid concentration in dementia of the Alzheimer type and multi-infarct dementia. ( 8726221 )
1996
86
Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. ( 8741021 )
1996
87
Senile dementia of Alzheimer type and multi-infarct dementia investigated by transcranial Doppler sonography. ( 8788081 )
1996
88
The Mini-Mental State Examination in Alzheimer's disease and multi-infarct dementia. ( 8805093 )
1996
89
Differences in dexamethasone-sensitivity between lymphocytes from patients with Alzheimer's disease and patients with multi-infarct dementia. ( 8811935 )
1996
90
On the EEG component waves of multi-infarct dementia seniles. ( 8828064 )
1996
91
European Pentoxifylline Multi-Infarct Dementia Study. ( 8864715 )
1996
92
Comparative study of aprosody in Alzheimer's disease and in multi-infarct dementia. ( 8866676 )
1996
93
Patterns of neuropsychological impairment in dementia of the Alzheimer type and multi-infarct dementia. ( 15374164 )
1996
94
Binswanger's disease presenting as levodopa-responsive parkinsonism: clinicopathologic study of three cases. ( 7565825 )
1995
95
Binswanger's disease--revisited. ( 7723946 )
1995
96
Platelet activation in the cerebral circulation in different subtypes of ischemic stroke and Binswanger's disease. ( 7839397 )
1995
97
Review: Binswanger's disease, leukoaraiosis and dementia. ( 8669355 )
1995
98
Psychiatric symptomatology in early-onset Binswanger's disease: two case reports. ( 24487402 )
1995
99
Binswanger's disease : no longer a rare entity. ( 29542475 )
1995
100
Design fluency in dementia of Alzheimer's type, multi-infarct dementia and dementia associated with alcoholism. ( 16318546 )
1995
101
Nicergoline in senile dementia of Alzheimer type and multi-infarct dementia: a double-blind, placebo-controlled, clinical and EEG/ERP mapping study. ( 7604138 )
1995
102
Long-term survival and predictors of mortality in Alzheimer's disease and multi-infarct dementia. ( 7793228 )
1995
103
Depressive symptoms in Alzheimer's disease and multi-infarct dementia. ( 7794481 )
1995
104
Hereditary multi-infarct dementia unlinked to chromosome 19q12 in a large Scottish pedigree: evidence of probable locus heterogeneity. ( 7897629 )
1995
105
(3H)hemicholinium-3 binding sites in postmortem brains of human patients with Alzheimer's disease and multi-infarct dementia. ( 8591807 )
1995
106
Patterns of neuropsychological impairment in mild dementia: a comparison between Alzheimer's disease and multi-infarct dementia. ( 8750107 )
1995
107
Serum alpha 1-antitrypsin and alpha 2-macroglobulin in Alzheimer's and Binswanger's disease. ( 7516751 )
1994
108
Review: Binswanger's disease, leukoaraiosis and dementia. ( 8010178 )
1994
109
White matter changes: neurobehavioral manifestations of Binswanger's disease and clinical correlates in Alzheimer's disease. ( 8087170 )
1994
110
Multi-infarct dementia (MID). ( 7853857 )
1994
111
A young case with multi-infarct dementia associated with lupus anticoagulant. ( 7919628 )
1994
112
Multi-infarct dementia. ( 8027633 )
1994
113
Serum tumor necrosis factor (TNF) in Alzheimer's disease and multi-infarct dementia. ( 8164471 )
1994
114
Verbal and spatial memory spans in Alzheimer's and multi-infarct dementia. ( 8191876 )
1994
115
Multi-infarct dementia in Down's syndrome. ( 8193456 )
1994
116
Multimodal evoked potentials in Binswanger's disease and Alzheimer's disease. ( 8083006 )
1993
117
An autopsy case of Binswanger's disease without hypertension and associated with cerebral infarction in the terminal stage. ( 8201801 )
1993
118
Occurrence of paroxysmal synchronous EEG discharges in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 8329820 )
1993
119
Hemineglect and seizures in Binswanger's disease: clinical-pathological report. ( 8331360 )
1993
120
A comparative I-123 IMP SPECT study in Binswanger's disease and Alzheimer's disease. ( 8482030 )
1993
121
Binswanger's disease. ( 8517210 )
1993
122
Differential rates of forgetting from long-term memory in Alzheimer's and multi-infarct dementia. ( 8132410 )
1993
123
Effect of CDP-choline on cognition and immune function in Alzheimer's disease and multi-infarct dementia. ( 8239305 )
1993
124
Single photon emission computerised tomography in elderly patients with Alzheimer's disease and multi-infarct dementia. Regional uptake of technetium-labelled HMPAO related to clinical measurements. ( 8298827 )
1993
125
Diagnosis of multi-infarct dementia: predictive value of clinical criteria. ( 8321588 )
1993
126
Responders and non-responders to bifemelane hydrochloride in Alzheimer-type and multi-infarct dementia. ( 8345159 )
1993
127
The value of transcranial Doppler sonography in the differential diagnosis of Alzheimer disease vs multi-infarct dementia. ( 8363702 )
1993
128
Delusions in Alzheimer's disease and multi-infarct dementia. ( 8372630 )
1993
129
CSF cholinesterase in early-onset and late-onset Alzheimer's disease and multi-infarct dementia of Chinese patients. ( 8424308 )
1993
130
Circulating immune complexes in sera from patients with Alzheimer's disease, multi-infarct dementia and Down's syndrome. ( 8469384 )
1993
131
Resting energy expenditure in relation to energy intake in patients with Alzheimer's disease, multi-infarct dementia and in control women. ( 8470560 )
1993
132
Gait disorders of multi-infarct dementia. CT and clinical correlation. ( 8475697 )
1993
133
Neuropsychological test patterns in men for Alzheimer's and multi-infarct dementia. ( 14589663 )
1993
134
Differences in erythrocyte aggregability between multi-infarct dementia and Alzheimer's disease. ( 26487254 )
1993
135
Regional cerebral blood flow measured with I-123 IMP SPECT in a case of subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 1424377 )
1992
136
Binswanger's disease and German translations. ( 1524510 )
1992
137
Binswanger's disease in the absence of chronic arterial hypertension. A case report with clinical, radiological and immunohistochemical observations on intracerebral blood vessels. ( 1575021 )
1992
138
Alzheimer and Kraepelin describe Binswanger's disease. ( 1627963 )
1992
139
Memory failure in binswanger's disease and alzheimer's disease. ( 29022447 )
1992
140
Serum histamine in Alzheimer's disease and multi-infarct dementia. ( 1294859 )
1992
141
DSM-III-R criteria for primary degenerative dementia and multi-infarct dementia [corrected]. ( 1389080 )
1992
142
Neuropathologic findings in multi-infarct dementia associated with anticardiolipin antibody. Evidence for endothelial injury as the primary event. ( 1418019 )
1992
143
Changes in brain functional connectivity in Alzheimer-type and multi-infarct dementia. ( 1422803 )
1992
144
Rating scales and computed tomography in multi-infarct dementia. ( 1463803 )
1992
145
Therapeutic efficacy of pyritinol in patients with senile dementia of the Alzheimer type (SDAT) and multi-infarct dementia (MID). ( 1475039 )
1992
146
Post-mortem proton magnetic resonance spectrometric measures of brain regions in patients with a pathological diagnosis of Alzheimer's disease and multi-infarct dementia. ( 1540758 )
1992
147
Cranial computed tomographic observations in multi-infarct dementia. A controlled study. ( 1595096 )
1992
148
Clinical studies with oxiracetam in patients with dementia of Alzheimer type and multi-infarct dementia of mild to moderate degree. ( 1603291 )
1992
149
Prevalence of moderate and severe Alzheimer dementia and multi-infarct dementia in the population of southeastern Sicily. ( 1624277 )
1992
150
Randomized, double-blind, placebo controlled, multicentre study of idebenone in patients suffering from multi-infarct dementia. ( 15374363 )
1992
151
Idebenone in the treatment of multi-infarct dementia: a randomised, double-blind, placebo controlled multicentre trial. ( 15374366 )
1992
152
Comparison of quantitative magnetic resonance imaging and positron emission tomography between patients with dementia of the alzheimer type and multi-infarct dementia. ( 26486837 )
1992
153
HELP application in multi-infarct dementia. ( 26486840 )
1992
154
Treatment of multi-infarct dementia with citicholine. ( 26486841 )
1992
155
Disturbance in cerebrovascular CO2 reactivity in multi-infarct dementia. ( 26486843 )
1992
156
Binswanger's clinical and neuropathological criteria for "Binswanger's disease". ( 1783935 )
1991
157
Evaluation of dementia in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 1834189 )
1991
158
Binswanger's disease: neither Binswanger's nor a disease. ( 1865221 )
1991
159
Binswanger's disease and normal-pressure hydrocephalus. Clinical and neuropsychological comparison. ( 1953401 )
1991
160
Platelet membrane fluidity in Alzheimer's disease and multi-infarct dementia: a spin label study. ( 1656688 )
1991
161
Interleukin-1 in Alzheimer's disease and multi-infarct dementia: neuropsychological correlations. ( 1770834 )
1991
162
Differences between multi-infarct dementia and Alzheimer's disease on unstructured neuropsychological tasks. ( 1779031 )
1991
163
Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia. ( 1835658 )
1991
164
Sleep-wake cycles in multi-infarct dementia and dementia of the Alzheimer type. ( 1922804 )
1991
165
Multi-infarct dementia, subcortical dementia, and hydrocephalus. ( 2035108 )
1991
166
SPECT in the diagnosis of Alzheimer's disease and multi-infarct-dementia. ( 1651190 )
1991
167
Multi-infarct dementia. ( 1753251 )
1991
168
Cerebral hypoperfusion correlates with mild and parenchymal loss with severe multi-infarct dementia. ( 1856730 )
1991
169
Prolactin responses to thyrotropin-releasing hormone in multi-infarct dementia and senile dementia of the Alzheimer type. ( 1906673 )
1991
170
Decreased cerebral glucose metabolism associated with mental deterioration in multi-infarct dementia. ( 1922743 )
1991
171
Study of the P300 and cerebral maps in subjects with multi-infarct dementia treated with cytidine. ( 2006235 )
1991
172
SLE and multi-infarct dementia. ( 2012934 )
1991
173
SIDAM--A structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia and dementias of other aetiology according to ICD-10 and DSM-III-R. ( 2047500 )
1991
174
Experimental basis of multi-infarct dementia: memory impairments in rodent models of ischemia. ( 2059402 )
1991
175
Diagnosis of multi-infarct dementia. ( 2059403 )
1991
176
Behavioral neurology of multi-infarct dementia. ( 2059404 )
1991
177
Cerebral blood flow and metabolism studies in multi-infarct dementia. ( 2059405 )
1991
178
Multi-infarct dementia: prevention and treatment. ( 2059406 )
1991
179
Multi-infarct dementia: a reappraisal. ( 2059408 )
1991
180
Epidemiology of multi-infarct dementia. ( 2059410 )
1991
181
The pathological basis of multi-infarct dementia. ( 2059411 )
1991
182
Cerebral magnetic resonance imaging compared in Alzheimer's and multi-infarct dementia. ( 7580172 )
1991
183
Longitudinal measurement of cerebral perfusion in patients with multi-infarct dementia. ( 26486265 )
1991
184
CSF beta-endorphin, HVA and 5-HIAA of dementia of the Alzheimer type and Binswanger's disease in the elderly. ( 1697333 )
1990
185
Binswanger's disease: a complete translation. ( 2206260 )
1990
186
Arteriolosclerotic leucoencephalopathy in the elderly and its relation to white matter lesions in Binswanger's disease, multi-infarct encephalopathy and Alzheimer's disease. ( 2230830 )
1990
187
Clinical diagnosis of Binswanger's disease. ( 2283526 )
1990
188
Binswanger's disease or artifact: a clinical, neuroimaging, and pathological study of periventricular white matter changes in Alzheimer's disease. ( 2294663 )
1990
189
Binswanger's disease: some neuropsychological considerations. ( 2346585 )
1990
190
Delusional depression responding to clomipramine in Binswanger's disease. ( 2366061 )
1990
191
MRI and neuropsychological correlates of dementia in Binswanger's disease. ( 14589547 )
1990
192
Giant cell (temporal) arteritis: a treatable cause of multi-infarct dementia. ( 2330100 )
1990
193
Pattern of language impairment is different in Alzheimer's disease and multi-infarct dementia. ( 1693304 )
1990
194
Substance P-like immunoreactivity, choline acetyltransferase activity and cholinergic muscarinic receptors in Alzheimer's disease and multi-infarct dementia. ( 1698512 )
1990
195
Is multi-infarct dementia representative of vascular dementias? A retrospective study. ( 1699387 )
1990
196
Effects of co-dergocrine mesylate (Hydergine) in multi-infarct dementia as evaluated by positron emission tomography. ( 2091324 )
1990
197
Severe atrophy of amygdala and hippocampus in both Alzheimer's disease and multi-infarct dementia. ( 2103656 )
1990
198
Methodological problems of clinical trials in multi-infarct dementia. ( 2215847 )
1990
199
Long-term experience of a trial in multi-infarct dementia. ( 2215848 )
1990
200
Depression in dementia of the Alzheimer type and in multi-infarct dementia. ( 2221160 )
1990
201
Personality alterations in multi-infarct dementia. ( 2247570 )
1990
202
Regional cerebral blood flow study with 99mTc-hexamethyl-propyleneamine oxime single photon emission computed tomography in Alzheimer's and multi-infarct dementia. ( 2269322 )
1990
203
White matter lucencies in multi-infarct dementia: a somatosensory evoked potentials and CT study. ( 2327242 )
1990
204
Coexistence of Alzheimer's disease and multi-infarct dementia diagnosed by functional brain imaging with SPECT. ( 2340662 )
1990
205
Insight for impairment in independent living skills in Alzheimer's disease and multi-infarct dementia. ( 2341561 )
1990
206
Course characteristics in the differentiation of dementia of the Alzheimer type and multi-infarct dementia. ( 2378248 )
1990
207
Plasma lipoprotein profiles and the distribution of high-density lipoprotein subfractions in the elderly: the effect of Alzheimer's disease and multi-infarct dementia. ( 2379739 )
1990
208
What contribution can the Hachinski Ischemic Scale make to the differential diagnosis between multi-infarct dementia and primary degenerative dementia? ( 15374494 )
1990
209
Pathological findings correlated with magnetic resonance imaging in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 2614428 )
1989
210
Binswanger's disease (Part I): The clinical recognition of subcortical arteriosclerotic encephalopathy in elderly neuropsychiatric patients. ( 2686675 )
1989
211
Binswanger's disease: a review of the literature and a personal contribution. ( 2693096 )
1989
212
Binswanger's disease (Part II): Pathogenesis of subcortical arteriosclerotic encephalopathy and its relation to other dementing processes. ( 2699555 )
1989
213
Computed tomography, magnetic resonance imaging and pathological correlations in a case of Binswanger's disease. ( 2731093 )
1989
214
Treatment of mood disorder associated with Binswanger's disease. ( 2775957 )
1989
215
The GBS scale in multi-infarct dementia and senile dementia of Alzheimer type. ( 2929386 )
1989
216
Ateroid in the clinical treatment of multi-infarct dementia. ( 2469953 )
1989
217
Clinical and biochemical responses to therapy in Alzheimer's disease and multi-infarct dementia. ( 2478368 )
1989
218
Neuropsychological results of long-term therapy with oxiracetam in patients with dementia of Alzheimer type and multi-infarct dementia in comparison with a control group. ( 2518332 )
1989
219
Oxiracetam in the treatment of multi-infarct dementia and primary degenerative dementia. ( 2521069 )
1989
220
Correlation between carotid blood flow and brain atrophy in patients with multi-infarct dementia. ( 2531110 )
1989
221
Alpha 1-adrenergic receptor binding sites in post-mortal human cerebral microvessel preparations: preservation in multi-infarct dementia and dementia of Alzheimer type. ( 2557046 )
1989
222
Brainstem auditory evoked potentials in patients with multi-infarct dementia and dementia of the Alzheimer type. ( 2583949 )
1989
223
Magnetic resonance imaging in Alzheimer's disease, multi-infarct dementia, alcoholic dementia and Korsakoff's psychosis. ( 2596343 )
1989
224
Plasma apolipoproteins in patients with multi-infarct dementia. ( 2597234 )
1989
225
Sensitivity and specificity of positron emission tomography and magnetic resonance imaging studies in Alzheimer's disease and multi-infarct dementia. ( 2612532 )
1989
226
Randomized clinical trial of daily aspirin therapy in multi-infarct dementia. A pilot study. ( 2654259 )
1989
227
Effects of intravenous high dose co-dergocrine mesylate ('Hydergine') in elderly patients with severe multi-infarct dementia: a double-blind, placebo-controlled trial. ( 2680286 )
1989
228
Amino acid concentrations in cerebrospinal fluid in presenile and senile dementia of Alzheimer type and multi-infarct dementia. ( 2686573 )
1989
229
Oxiracetam in the treatment of primary degenerative and multi-infarct dementia: a double-blind, placebo-controlled study. ( 2693996 )
1989
230
Multi-infarct dementia: a computed tomographic study. ( 2728852 )
1989
231
Selective preservation of oral spelling without semantics in a case of multi-infarct dementia. ( 2758850 )
1989
232
Oxiracetam in the treatment of multi-infarct dementia. ( 2781039 )
1989
233
Predictors of survival in clinically diagnosed Alzheimer's disease and multi-infarct dementia. ( 2818256 )
1989
234
Binswanger's disease: a cause of dementia in the elderly. ( 3175742 )
1988
235
Binswanger's disease after prednisolone and azathioprine therapy. ( 3176885 )
1988
236
Computerized tomographic findings and differential diagnostic considerations in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 3179978 )
1988
237
Alterations of short-latency somatosensory evoked potentials in subcortical arteriosclerotic encephalopathy (Binswanger's Disease): a preliminary report. ( 3191878 )
1988
238
Single-photon emission tomography with technetium Tc 99m hexamethylpropylene amine oxime in Binswanger's disease. ( 3259420 )
1988
239
Reversible depression in Binswanger's disease. ( 3335486 )
1988
240
Why not Binswanger's disease? ( 3341928 )
1988
241
Understanding and treating multi-infarct dementia. ( 3066458 )
1988
242
Visual evoked potentials in elderly patients with primary or multi-infarct dementia. ( 3167445 )
1988
243
Is determination of plasma lipids useful in the differentiation of multi-infarct dementia from Alzheimer's disease? ( 3197048 )
1988
244
A comparison of brain choline acetyltransferase activity in Alzheimer's disease, multi-infarct dementia, and combined dementia. ( 3210004 )
1988
245
Aetiological considerations and risk factors for multi-infarct dementia. ( 3221215 )
1988
246
Platelet MAO-B activity and the psychopathology of Parkinson's disease, senile dementia and multi-infarct dementia. ( 3223331 )
1988
247
Auditory long latency event-related potentials in Alzheimer's disease and multi-infarct dementia. ( 3225596 )
1988
248
Clonazepam treatment of multi-infarct dementia. ( 3252876 )
1988
249
A comparison of Tc-99m HM-PAO and I-123 IMP cerebral SPECT images in Alzheimer's disease and multi-infarct dementia. ( 3265101 )
1988
250
Cognition and cerebral blood flow fluctuate together in multi-infarct dementia. ( 3344529 )
1988
251
Speech and language alterations in multi-infarct dementia. ( 3362367 )
1988
252
Cerebrospinal fluid neuron-specific enolase is decreased in multi-infarct dementia, but unchanged in Alzheimer's disease. ( 3379429 )
1988
253
Magnetic resonance imaging in pre-senile dementia of the Alzheimer-type, multi-infarct dementia and Korsakoff's syndrome. ( 3399584 )
1988
254
Purine metabolites in the CSF in presenile and senile dementia of Alzheimer type, and in multi infarct dementia. ( 3415397 )
1988
255
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Report of a case simulating psychiatric disease and normal pressure hydrocephalus. ( 3473291 )
1987
256
High-resolution nuclear magnetic resonance imaging and single photon emission computerized tomography--cerebral blood flow in a case of pure sensory stroke and mild dementia owing to subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 3502532 )
1987
257
Gait disorder of subcortical arteriosclerotic encephalopathy: Binswanger's disease. ( 3504256 )
1987
258
Binswanger's disease: a review. ( 3544352 )
1987
259
The role of plasma hyperviscosity in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 3559641 )
1987
260
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Presentation of two cases. ( 3604757 )
1987
261
Subcortical arteriosclerotic encephalopathy (Binswanger's disease): a report of five patients. ( 3618106 )
1987
262
White matter lucencies on computed tomography, subacute arteriosclerotic encephalopathy (Binswanger's disease), and blood pressure. ( 3629649 )
1987
263
Subcortical arteriosclerotic encephalopathy: Binswanger's disease. ( 3665181 )
1987
264
Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. ( 3116954 )
1987
265
Electroencephalographic spectra and coherence in the diagnosis of Alzheimer's-type and multi-infarct dementia. A pilot study. ( 3314770 )
1987
266
Multi-infarct dementia: diagnosis and management. Infarctions produce 20% to 35% of severe dementia cases. ( 3324157 )
1987
267
Effects of the opiate antagonist naloxone on learning and memory in patients with multi-infarct dementia. ( 3422881 )
1987
268
Serum and cerebrospinal fluid proteins and the blood-brain barrier in Alzheimer's disease and multi-infarct dementia. ( 3595662 )
1987
269
Cyclandelate in the treatment of multi-infarct dementia. Interim findings from a multicentre study in general practice. ( 3622304 )
1987
270
Types of multi-infarct dementia. ( 3630635 )
1987
271
Hereditary multi-infarct dementia. ( 3678285 )
1987
272
Multi-infarct dementia. ( 3806886 )
1987
273
Urinary and gait disturbances as markers for early multi-infarct dementia. ( 3810746 )
1987
274
Neuropsychiatric aspects of multi-infarct dementia and dementia of the Alzheimer type. ( 3827694 )
1987
275
The validity of Binswanger's disease. ( 3719470 )
1986
276
Binswanger's disease. ( 3729740 )
1986
277
"Multi-infarct" dementia. A real entity? ( 3700937 )
1986
278
Multi-infarct dementia. ( 3713668 )
1986
279
HLA system in senile dementia of Alzheimer type and multi-infarct dementia in Japan. ( 3718071 )
1986
280
Revised ischemic score for diagnosing multi-infarct dementia. ( 3733680 )
1986
281
Improved cognition after control of risk factors for multi-infarct dementia. ( 3761519 )
1986
282
Survival and cause of death in Alzheimer's disease and multi-infarct dementia. ( 3776457 )
1986
283
Prevalence and incidence of senile and multi-infarct dementia in the Lundby Study: a comparison between the time periods 1947-1957 and 1957-1972. ( 3785641 )
1986
284
Decreased cerebral blood flow precedes multi-infarct dementia, but follows senile dementia of Alzheimer type. ( 3941761 )
1986
285
DSM-III diagnosis of multi-infarct dementia. ( 3948503 )
1986
286
Cognitive performance correlates with cerebrovascular impairments in multi-infarct dementia. ( 3958410 )
1986
287
WAIS testing in degenerative and multi-infarct dementia. ( 3962755 )
1986
288
Neuropsychological performance in dementia of the Alzheimer type and multi-infarct dementia. ( 14591413 )
1986
289
Binswanger's disease: progressive subcortical encephalopathy or multi-infarct dementia? ( 4016596 )
1985
290
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Computed tomographic, nuclear magnetic resonance, and clinical correlations. ( 4038102 )
1985
291
Homovanillic acid and 5-hydroxyindoleacetic acid modifications in CSF of patients with stroke and multi-infarct dementia. ( 2418548 )
1985
292
Alzheimer's disease and multi-infarct dementia. ( 2857311 )
1985
293
CSF beta-endorphin and beta-lipotropin in Alzheimer's disease and multi-infarct dementia. ( 3159972 )
1985
294
Haptoglobin groups in dementia of Alzheimer type and multi-infarct dementia. ( 3972421 )
1985
295
Forty Hertz EEG activity in dementia of the Alzheimer type and multi-infarct dementia. ( 3975317 )
1985
296
The integrity of the blood-brain barrier in Alzheimer's type and multi-infarct dementia evaluated by the study of albumin and IgG in serum and cerebrospinal fluid. ( 3981221 )
1985
297
Multi-infarct dementia: a clinicopathological correlation. ( 4044478 )
1985
298
Revised Ischemic Score for diagnosing multi-infarct dementia. ( 4066617 )
1985
299
Mortality and age psychosis in the Lundby Study: death risk of senile and multi-infarct dementia. Changes over time in a prospective study of a total population followed over 25 or 15 years. ( 4069345 )
1985
300
Multi-infarct dementia clinical and morphological correlations. ( 4081571 )
1985
301
Single photon emission tomography with 123I-isopropylamphetamine in Alzheimer's disease and multi-infarct dementia. ( 6150361 )
1984
302
Dementia of the Alzheimer type and multi-infarct dementia: a clinical description and diagnostic problems. ( 6203954 )
1984
303
Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multi-infarct dementia. ( 6436437 )
1984
304
The effects of bromvincamine and vincamine on regional cerebral blood flow and mental functions in patients with multi-infarct dementia. ( 6436861 )
1984
305
Multi-infarct dementia. ( 6443555 )
1984
306
CT-CBF correlations of cognitive deficits in multi-infarct dementia. ( 6506109 )
1984
307
Drug-induced repetitive sharp EEG discharges in multi-infarct dementia. ( 6519439 )
1984
308
Xenon contrast CT-CBF scanning of the brain differentiates normal age-related changes from multi-infarct dementia and senile dementia of Alzheimer type. ( 6736577 )
1984
309
Diagnosis of Alzheimer's disease and multi-infarct dementia by rCBF compared to clinical classification. ( 6738541 )
1984
310
Prevalence of Binswanger's disease. ( 6132262 )
1983
311
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 6823631 )
1983
312
Differentiating senile dementia of Alzheimer type and multi-infarct dementia by proton NMR imaging. ( 6137619 )
1983
313
Parental stroke: risk factors for multi-infarct dementia? ( 6138566 )
1983
314
The fluorodeoxyglucose 18F scan in Alzheimer's disease and multi-infarct dementia. ( 6605139 )
1983
315
Hypertension, multi-infarct dementia and Alzheimer's disease. ( 6626840 )
1983
316
Albumin and immunoglobulin in plasma and cerebrospinal fluid, and blood-cerebrospinal fluid barrier function in patients with dementia of Alzheimer type and multi-infarct dementia. ( 6631444 )
1983
317
Clinical differentiation of primary degenerative and multi-infarct dementia: a critical review of the evidence. Part I: Clinical studies. ( 6661473 )
1983
318
Clinical differentiation of primary degenerative and multi-infarct dementia: a critical review of the evidence. Part II: Pathological studies. ( 6661474 )
1983
319
Current trends in the incidence of senile and multi-infarct dementia. A prospective study of a total population followed over 25 years; the Lundby Study. ( 6667099 )
1983
320
Multi-infarct dementia. ( 6680161 )
1983
321
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 7151918 )
1982
322
Vascular-(multi-infarct-)dementia versus primarily degenerative (Alzheimer's) dementia: a study of rCBF and computed tomography (CT). ( 7151910 )
1982
323
Cerebrospinal fluid investigations in multi-infarct dementia and senile dementia. ( 7324870 )
1981
324
The electroencephalogram in dementia. Differential diagnostic value in Alzheimer's disease, senile dementia and multi-infarct dementia. ( 7337001 )
1981
325
Multi-infarct dementia. ( 430104 )
1979
326
Effect of tinofedrine (Homburg D8955) on cerebral blood flow in multi-infarct dementia. ( 731238 )
1978
327
Comparison of angiographic and CT findings between patients with multi-infarct dementia and those with dementia due to primary neuronal degeneration. ( 740146 )
1978
328
Hereditary multi-infarct dementia. ( 67459 )
1977
329
The relationship between regional oxygen utilization and cerebral blood flow in multi-infarct dementia. ( 268799 )
1977
330
Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. ( 301148 )
1977
331
Regional cerebral blood flow statistical patterns and psychological performance in multi-infarct dementia and Alzheimer's disease. ( 837265 )
1977
332
Hereditary multi-infarct dementia. Morphological and clinical studies of a new disease. ( 906807 )
1977
333
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). A vascular etiology of dementia. ( 1006740 )
1976
334
Intellectual performance in multi-infarct dementia and Alzheimer's disease a replication study. ( 963637 )
1976
335
Analysis of intellectual and cognitive performance in patients with multi-infarct dementia, vertebrobasilar insufficiency with dementia, and Alzheimer's disease. ( 1151420 )
1975
336
Multi-infarct dementia. A cause of mental deterioration in the elderly. ( 4135618 )
1974
337
A case of subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 5068470 )
1972
338
A CASE OF ENCEPHALOPATHIA SUBCORTICALIS CHRONICA (BINSWANGER'S DISEASE). ( 14129108 )
1964
339
DIFFUSE DEGENERATION OF CEREBRAL WHITE MATTER RESEMBLING SOCALLED BINSWANGER'S DISEASE AND SYMMETRICAL NECROSIS OF THE GLOBUS PALLIDUS ASSOCIATED WITH ACUTE PORPHYRIA AND CEREBRAL ATHEROSCLEROSIS. ( 14063325 )
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Subcortical arteriosclerotic encephalopathy. Review of the literature on the so-called Binswanger's disease and presentation of two cases. ( 14481961 )
1962

Variations for Binswanger's Disease

Expression for Binswanger's Disease

Search GEO for disease gene expression data for Binswanger's Disease.

Pathways for Binswanger's Disease

Pathways related to Binswanger's Disease according to GeneCards Suite gene sharing:

(showing 4, show less)
# Super pathways Score Top Affiliating Genes
1 11.7 APOE APP GFAP MAPT NOTCH3 SYP
2 11.34 APOE APP MAPT
3 11.11 APOE APP MAPT
4 10.79 APOE APP MAPT

GO Terms for Binswanger's Disease

Cellular components related to Binswanger's Disease according to GeneCards Suite gene sharing:

(showing 10, show less)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.95 ACHE ACTC1 APOE APP CHGA CRH
2 neuron projection GO:0043005 9.78 APP MAPT SYP VIP
3 neuronal cell body GO:0043025 9.76 APOE CRH MAPT SST
4 synaptic cleft GO:0043083 9.43 ACHE APOE
5 cell body GO:0044297 9.43 ACTC1 GFAP MAPT
6 astrocyte projection GO:0097449 9.37 APP GFAP
7 neuromuscular junction GO:0031594 9.33 ACHE APP SYP
8 glial cell projection GO:0097386 9.32 GFAP MAPT
9 extracellular region GO:0005576 9.32 ACHE APOE APP CHGA CRH MAPT
10 main axon GO:0044304 8.96 APP MAPT

Biological processes related to Binswanger's Disease according to GeneCards Suite gene sharing:

(showing 17, show less)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.86 ACTC1 APP CRH PLP1
2 negative regulation of gene expression GO:0010629 9.62 APOE APP CRH MAPT
3 artery morphogenesis GO:0048844 9.57 APOE NOTCH3
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.55 APP SYP
5 response to lead ion GO:0010288 9.54 APP MAPT
6 regulation of neuronal synaptic plasticity GO:0048168 9.52 APOE SYP
7 regulation of NMDA receptor activity GO:2000310 9.51 APP CRH
8 astrocyte development GO:0014002 9.49 GFAP PLP1
9 locomotory exploration behavior GO:0035641 9.48 APOE CRH
10 amyloid precursor protein metabolic process GO:0042982 9.46 ACHE APOE
11 astrocyte activation GO:0048143 9.43 APP MAPT
12 learning or memory GO:0007611 9.43 APP CRH VIP
13 negative regulation of long-term synaptic potentiation GO:1900272 9.4 APOE APP
14 amyloid fibril formation GO:1990000 9.37 APP MAPT
15 hormone-mediated apoptotic signaling pathway GO:0008628 9.16 CRH SST
16 positive regulation of amyloid fibril formation GO:1905908 8.96 APOE APP
17 axon development GO:0061564 8.8 GFAP MAPT PLP1

Molecular functions related to Binswanger's Disease according to GeneCards Suite gene sharing:

(showing 4, show less)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 APOE APP GFAP MAPT NOTCH3 SYP
2 hormone activity GO:0005179 9.33 CRH SST VIP
3 neuropeptide hormone activity GO:0005184 9.26 CRH VIP
4 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Binswanger's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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