MCID: BPH002
MIFTS: 28

Biphasic Synovial Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Biphasic Synovial Sarcoma

MalaCards integrated aliases for Biphasic Synovial Sarcoma:

Name: Biphasic Synovial Sarcoma 12 15
Synovial Sarcoma, Biphasic 12 71
Biphasic Sarcoma of Synovium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5492
NCIt 49 C4279
SNOMED-CT 67 18588008
UMLS 71 C0334507

Summaries for Biphasic Synovial Sarcoma

MalaCards based summary : Biphasic Synovial Sarcoma, also known as synovial sarcoma, biphasic, is related to rare tumor and spindle cell sarcoma. An important gene associated with Biphasic Synovial Sarcoma is SS18 (SS18 Subunit Of BAF Chromatin Remodeling Complex), and among its related pathways/superpathways are Cytoskeletal Signaling and Transcriptional misregulation in cancer. Affiliated tissues include bone, heart and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Biphasic Synovial Sarcoma

Diseases related to Biphasic Synovial Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 rare tumor 30.9 EWSR1 DES
2 spindle cell sarcoma 30.5 VIM SSX2 SSX1 SS18 MUC1 DES
3 mesenchymal cell neoplasm 30.4 SSX2 SS18 EWSR1
4 cavernous hemangioma 30.3 VIM MUC1 DES
5 papillary carcinoma 29.7 MUC1 CDH1 CALB2
6 mesothelioma, malignant 29.5 VIM MUC1 DES CDH1 CALB2
7 ewing sarcoma 29.5 VIM SSX1 SS18 EWSR1 DES
8 lung sarcoma 29.4 SSX2 SSX1 SS18 CALB2
9 sarcoma 29.2 VIM SSX4B SSX4 SSX2 SSX1 SS18
10 monophasic synovial sarcoma 27.6 VIM TLE1 SSX4B SSX2 SSX1 SS18
11 sarcoma, synovial 26.5 VIM TLE1 SSX4B SSX4 SSX2 SSX1
12 gallbladder signet ring cell adenocarcinoma 10.5 MUC1 CDH1
13 infantile digital fibromatosis 10.4 VIM DES
14 fibromatosis 10.4 VIM DES
15 lymphangiomatosis 10.4 VIM DES
16 primitive neuroectodermal tumor of the cervix uteri 10.4 VIM DES
17 cutaneous leiomyosarcoma 10.4 MUC1 DES
18 syringocystadenoma papilliferum 10.4 MUC1 DES
19 congenital epulis 10.4 VIM DES
20 epulis 10.4 VIM DES
21 mesenchymoma 10.4 SSX2 DES
22 plasmablastic lymphoma 10.4 MUC1 DES
23 benign metastasizing leiomyoma 10.4 VIM DES
24 papillary tumor of the pineal region 10.4 VIM MUC1
25 nodular hidradenoma 10.4 VIM MUC1
26 hidradenoma 10.4 VIM MUC1
27 endometrial mucinous adenocarcinoma 10.4 VIM MUC1
28 angiolipoma 10.4 VIM DES
29 glomangioma 10.4 VIM DES
30 meninges sarcoma 10.4 SSX2 SS18
31 cellular schwannoma 10.4 SSX1 SS18
32 proximal spinal muscular atrophy 10.4 MUC1 DES
33 chondroid chordoma 10.4 VIM MUC1
34 spindle cell lipoma 10.4 VIM DES
35 adenoid squamous cell carcinoma 10.4 VIM CDH1
36 gastric diffuse adenocarcinoma 10.4 MUC1 CDH1
37 eccrine porocarcinoma 10.4 VIM MUC1
38 spindle cell rhabdomyosarcoma 10.4 MUC1 DES
39 embryonal sarcoma 10.4 VIM DES
40 anaplastic ependymoma 10.4 VIM MUC1
41 chordoid meningioma 10.4 VIM MUC1
42 polymorphous low-grade adenocarcinoma 10.3 VIM MUC1
43 clear cell ependymoma 10.3 VIM MUC1
44 secretory meningioma 10.3 VIM MUC1
45 fibrous meningioma 10.3 VIM MUC1
46 ischemic fasciitis 10.3 MUC1 DES
47 bile duct adenoma 10.3 VIM MUC1
48 spermatic cord cancer 10.3 SSX2 SSX1
49 dendritic cell tumor 10.3 VIM MUC1
50 chondromyxoid fibroma 10.3 VIM DES

Graphical network of the top 20 diseases related to Biphasic Synovial Sarcoma:



Diseases related to Biphasic Synovial Sarcoma

Symptoms & Phenotypes for Biphasic Synovial Sarcoma

GenomeRNAi Phenotypes related to Biphasic Synovial Sarcoma according to GeneCards Suite gene sharing:

26 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.1 SSX2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.1 EWSR1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.1 TLE1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.1 SSX1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.1 EWSR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.1 TLE1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.1 EWSR1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.1 EWSR1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.1 EWSR1 TLE1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.1 TLE1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.1 SSX1 SSX2 SSX4 SSX4B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.1 EWSR1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.1 EWSR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.1 TLE1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.1 EWSR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-191 10.1 SSX2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.1 SSX4 SSX4B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.1 SSX1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.1 SSX2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.1 EWSR1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.1 SSX4 SSX4B
22 Increased shRNA abundance (Z-score > 2) GR00366-A-51 10.1 SSX4 SSX4B
23 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.1 SSX1 EWSR1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-60 10.1 TLE1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.1 SSX1 TLE1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.1 SSX4 SSX4B
27 Increased shRNA abundance (Z-score > 2) GR00366-A-76 10.1 SSX2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-77 10.1 SSX1 SSX2 EWSR1 TLE1
29 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.1 SSX2 EWSR1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.1 SSX4 SSX4B TLE1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.1 EWSR1

Drugs & Therapeutics for Biphasic Synovial Sarcoma

Search Clinical Trials , NIH Clinical Center for Biphasic Synovial Sarcoma

Genetic Tests for Biphasic Synovial Sarcoma

Anatomical Context for Biphasic Synovial Sarcoma

MalaCards organs/tissues related to Biphasic Synovial Sarcoma:

40
Bone, Heart, Lung, Thyroid, Small Intestine, Colon, Kidney

Publications for Biphasic Synovial Sarcoma

Articles related to Biphasic Synovial Sarcoma:

(show top 50) (show all 142)
# Title Authors PMID Year
1
From fine-needle aspiration cytology to fluorescent in-situ hybridization in an unusual case of pharyngeal synovial sarcoma. 61
31293093 2019
2
PAX8-positive Biphasic Synovial Sarcoma Expressing Hormonal Receptors. 61
28248726 2019
3
Primary synovial sarcoma of the ovary and Fallopian tube - case report and review of the literature. 61
31324112 2019
4
Primary thyroid biphasic synovial sarcoma and synchronous papillary carcinoma: report of a remarkable case. 61
30546147 2018
5
Laser capture microdissection for detecting the expression of epithelial-mesenchymal transition-related genes in epithelial and spindle cells of paraffin-embedded formalin-fixed biphasic synovial sarcoma. 61
29575169 2018
6
Biphasic synovial sarcoma of the epiglottis: Case report and literature review. 61
28689931 2018
7
Synovial sarcoma of the transverse colon: a rare cause of intussusception. 61
29602893 2018
8
Primary biphasic synovial sarcoma of the right atrium. 61
26178188 2018
9
PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy. 61
30524904 2018
10
Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene. 61
28731043 2017
11
Biphasic synovial sarcoma with prominent cavernous hemangioma-like stroma. 61
27988941 2017
12
Claudin-4 expression distinguishes SWI/SNF complex-deficient undifferentiated carcinomas from sarcomas. 61
28084340 2017
13
Transoral robotic surgery for the pediatric head and neck surgeries. 61
28004263 2017
14
Monosomy 22 and partial loss of INI1 expression in a biphasic synovial sarcoma with an Ewing sarcoma-like poorly differentiated component: Report of a case. 61
27118264 2016
15
Intravascular Biphasic Synovial Sarcoma: The Beneficial Role of Adjuvant Treatment Approach in the Pre-metastatic Stage. 61
27190730 2016
16
Primary mediastinal synovial sarcoma: A rare case report. 61
27621098 2016
17
Primary synovial sarcoma of the right heart involving the tricuspid valve in an elderly Chinese woman: a case report. 61
26112006 2015
18
Biphasic synovial sarcoma of the hypopharynx. 61
25923284 2015
19
Biphasic synovial sarcoma in a 19-year-old pregnant woman: a case report. 61
25826519 2015
20
Superficial soft tissue biphasic synovial sarcoma with apocrine differentiation in the glandular component: a report of two cases. 61
23563252 2014
21
Epidemiology and survivorship of soft tissue sarcomas in adults: a national cancer database report. 61
25044961 2014
22
Primary peripheral neurolymphomatosis mimicking synovial sarcoma: FDG PETCT to the rescue. 61
25313768 2014
23
SS18-bronchial biphasic synovial sarcoma in an octogenarian with hemothorax. 61
24429587 2014
24
A non-joint tissue biphasic synovial sarcoma in a dog. 61
24447570 2014
25
Primary biphasic synovial sarcoma of gingiva: Report of a rare case. 61
24959041 2014
26
Primary intra-abdominal synovial sarcoma: a case report. 61
24556573 2013
27
Pediatric primitive intraneural synovial sarcoma of L-5 nerve root. 61
23414131 2013
28
Primary intra-abdominal synovial sarcoma: a case report. 61
24505604 2013
29
Laryngeal synovial sarcoma: a rare clinical entity. 61
23984145 2013
30
MUC4 is a sensitive and extremely useful marker for sclerosing epithelioid fibrosarcoma: association with FUS gene rearrangement. 61
22982887 2012
31
Biphasic synovial sarcoma arising from superior vena cava. 61
22419995 2012
32
Primary intrathoracic biphasic synovial sarcoma. 61
22519387 2012
33
Vascular endothelial growth factor receptor 2 as a marker for malignant vascular tumors and mesothelioma: an immunohistochemical study of 262 vascular endothelial and 1640 nonvascular tumors. 61
22314185 2012
34
Pericardium: an exceedingly rare site for a primary biphasic synovial sarcoma. 61
22771650 2012
35
Primary pulmonary biphasic synovial sarcoma: a case report and literature review. 61
22472156 2012
36
Synovial sarcoma involving the median nerve: a case report. 61
23011830 2012
37
Claudin-5 as an immunohistochemical marker for angiosarcoma and hemangioendotheliomas. 61
21959309 2011
38
Biphasic synovial sarcoma in the cervical spine: Case report. 61
21605432 2011
39
Biphasic synovial sarcoma in mandibular region. 61
22529590 2011
40
Biphasic synovial sarcoma of the extremity: quadruple approach of isolated limb perfusion, surgical ablation, adipofascial perforator flap and radiation to avoid amputation. 61
21516237 2011
41
Primary synovial sarcoma of the mediastinum : a case report. 61
22606585 2011
42
Posterior mediastinal biphasic synovial sarcoma in a 12 year-old boy: a case report and review of literature. 61
21358103 2010
43
Primary pulmonary biphasic synovial sarcoma confirmed by molecular detection of a SYT-SSX2 fusion gene: report of 1 case. 61
20830232 2010
44
[Primary biphasic synovial sarcoma of the kidney]. 61
20094701 2010
45
Cytogenetic heterogeneity in biphasic synovial sarcoma associated with telomere instability. 61
20113844 2010
46
Synovial Sarcoma: A Clinicopathological and Radiological Study of 12 Cases Seen Over 18 Years. 61
29147174 2010
47
Cryptic SYT/SXX1 fusion gene in high-grade biphasic synovial sarcoma with unique complex rearrangement and extensive BCL2 overexpression. 61
20082858 2010
48
A distinctive novel epitheliomesenchymal biphasic tumor of the stomach in young adults ("gastroblastoma"): a series of 3 cases. 61
19718790 2009
49
The classic prognostic factors tumor stage, tumor size, and tumor grade are the strongest predictors of outcome in synovial sarcoma: no role for SSX fusion type or ezrin expression. 61
18997619 2009
50
Biphasic synovial sarcoma. 61
18761552 2009

Variations for Biphasic Synovial Sarcoma

Expression for Biphasic Synovial Sarcoma

Search GEO for disease gene expression data for Biphasic Synovial Sarcoma.

Pathways for Biphasic Synovial Sarcoma

Pathways related to Biphasic Synovial Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 VIM MUC1 DES CDH1
2 11.19 SSX2 SSX1 SS18 EWSR1
3 10.41 VIM CDH1

GO Terms for Biphasic Synovial Sarcoma

Cellular components related to Biphasic Synovial Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.36 VIM TLE1 SSX4B SSX4 SSX2 SSX1

Biological processes related to Biphasic Synovial Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.43 TLE1 SSX4B SSX4 SSX2 SSX1 EWSR1
2 intermediate filament organization GO:0045109 8.62 VIM DES

Sources for Biphasic Synovial Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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