MCID: BPL003
MIFTS: 60

Bipolar Disorder

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Bipolar Disorder

MalaCards integrated aliases for Bipolar Disorder:

Name: Bipolar Disorder 38 12 76 53 25 37 55 43 44 15 73
Major Affective Disorder 53 40 73
Bipolar Affective Disorder 53 25
Depression, Bipolar 25 73
Bipolar Depression 12 15
Manic Depression 12 53
Manic Disorder 12 73
Manic Bipolar Affective Disorder 12
Bipolar Disorder Manic Phase 12
Bipolar Affective Psychosis 25
Major Affective Disorder 1 73
Manic-Depressive Psychosis 53
Major Affective Disorder 2 73
Manic Depressive Disorder 12
Bipolar Spectrum Disorder 25
Manic Bipolar I Disorder 12
Manic Depressive Illness 25
Affective Disorder Major 55
Depressive-Manic Psych. 12
Bipolar Disorder, Mixed 73
Mixed Bipolar Disorder 12
Depression Bipolar 55
Bipolar Illness 53

Classifications:



Summaries for Bipolar Disorder

MedlinePlus : 43 Bipolar disorder is a serious mental illness. People who have it go through unusual mood changes. They go from very happy, "up," and active to very sad and hopeless, "down," and inactive, and then back again. They often have normal moods in between. The up feeling is called mania. The down feeling is depression. The causes of bipolar disorder aren't always clear. It runs in families. Abnormal brain structure and function may also play a role. Bipolar disorder often starts in a person's late teen or early adult years. But children and adults can have bipolar disorder too. The illness usually lasts a lifetime. If you think you may have it, tell your health care provider. A medical checkup can rule out other illnesses that might cause your mood changes. If not treated, bipolar disorder can lead to damaged relationships, poor job or school performance, and even suicide. However, there are effective treatments to control symptoms: medicine and talk therapy. A combination usually works best. NIH: National Institute of Mental Health

MalaCards based summary : Bipolar Disorder, also known as major affective disorder, is related to major depressive disorder and schizophrenia. An important gene associated with Bipolar Disorder is DAOA-AS1 (DAOA Antisense RNA 1), and among its related pathways/superpathways is Neurotransmitter Clearance In The Synaptic Cleft. The drugs Lamotrigine and Ziprasidone have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A mood disorder that involves alternating periods of mania and depression.

Genetics Home Reference : 25 Bipolar disorder is a mental health condition that causes extreme shifts in mood, energy, and behavior. This disorder most often appears in late adolescence or early adulthood, although symptoms can begin at any time of life.

NIH Rare Diseases : 53 Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. Signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). Mood episodes may also include symptoms of both mania and depression (a mixed state). It often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. Bipolar disorder can run in families, although no single gene is thought to cause the condition. Many factors acting together likely increase a person's risk to develop the disorder. Treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms.

Wikipedia : 76 Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of... more...

Related Diseases for Bipolar Disorder

Diseases in the Bipolar Disorder family:

Bipolar Ll Disorder Bipolar I Disorder

Diseases related to Bipolar Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 319)
# Related Disease Score Top Affiliating Genes
1 major depressive disorder 32.9 BDNF COMT DISC1 DISC2 DRD3 SLC6A4
2 schizophrenia 32.8 ATP2A2 BDNF COMT DAOA DAOA-AS1 DISC1
3 schizoaffective disorder 32.8 BDNF COMT DAOA DISC1 DISC2 DRD3
4 bipolar i disorder 32.8 BDNF COMT SLC6A4
5 depression 32.8 BDNF DISC2 RELN SLC6A4
6 psychotic disorder 32.7 BDNF COMT DAOA DISC1 DRD3 RELN
7 mood disorder 32.6 BDNF COMT DAOA DISC1 DISC2 DRD3
8 migraine with or without aura 1 32.4 COMT DRD3 SLC6A4
9 schizophrenia 2 31.8 DISC1 DISC2
10 anxiety 31.6 BDNF COMT SLC6A4
11 personality disorder 31.5 BDNF COMT SLC6A4
12 borderline personality disorder 31.5 BDNF COMT SLC6A4
13 attention deficit-hyperactivity disorder 31.3 BDNF COMT DRD3 SLC6A4
14 mental depression 31.3 BDNF COMT SLC6A4
15 obsessive-compulsive disorder 31.2 BDNF COMT DRD3 SLC6A4
16 substance abuse 31.1 BDNF COMT DRD3 SLC6A4
17 autism 31.1 BDNF COMT DISC1 DRD3 RELN SLC6A4
18 alcohol dependence 31.0 BDNF COMT DRD3 SLC6A4
19 substance dependence 31.0 BDNF DRD3 SLC6A4
20 eating disorder 30.9 BDNF COMT SLC6A4
21 alcohol abuse 30.9 BDNF DRD3 SLC6A4
22 paranoid schizophrenia 30.8 BDNF COMT SLC6A4
23 panic disorder 30.8 BDNF COMT DAOA-AS1 SLC6A4
24 generalized anxiety disorder 30.6 BDNF COMT SLC6A4
25 pervasive developmental disorder 30.6 BDNF RELN SLC6A4
26 disease of mental health 30.6 BDNF COMT DISC1 DRD3 RELN SLC6A4
27 postpartum depression 30.6 BDNF COMT SLC6A4
28 autism spectrum disorder 30.5 BDNF DISC2 RELN SLC6A4
29 tardive dyskinesia 30.5 COMT DRD3
30 post-traumatic stress disorder 30.4 BDNF COMT SLC6A4
31 oppositional defiant disorder 30.2 COMT SLC6A4
32 alexithymia 30.2 COMT SLC6A4
33 bulimia nervosa 30.2 BDNF COMT SLC6A4
34 traumatic brain injury 30.2 BDNF COMT
35 anorexia nervosa 30.1 BDNF COMT SLC6A4
36 parkinson disease, late-onset 30.1 BDNF COMT DRD3 SLC6A4
37 pathological gambling 30.0 DRD3 SLC6A4
38 major affective disorder 3 11.5
39 major affective disorder 1 11.4
40 major affective disorder 8 11.4
41 major affective disorder 7 11.4
42 major affective disorder 9 11.4
43 cyclothymic disorder 11.2
44 major affective disorder 2 11.1
45 major affective disorder 4 11.1
46 major affective disorder 5 11.1
47 major affective disorder 6 11.1
48 valproate embryopathy 11.1
49 darier-white disease 10.9
50 mental retardation, x-linked, syndromic 13 10.9

Comorbidity relations with Bipolar Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Diabetes Insipidus, Nephrogenic, Autosomal
Hypertension, Essential Hypothyroidism
Major Affective Disorder 9 Major Depressive Disorder
Parkinson Disease, Late-Onset Schizophrenia
Schizophreniform Disorder Tardive Dyskinesia

Graphical network of the top 20 diseases related to Bipolar Disorder:



Diseases related to Bipolar Disorder

Symptoms & Phenotypes for Bipolar Disorder

GenomeRNAi Phenotypes related to Bipolar Disorder according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.62 IMPA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.62 DRD3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.62 DRD3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.62 ATP2A2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.62 DRD3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.62 DRD3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.62 DRD3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.62 ATP2A2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.62 ATP2A2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.62 ATP2A2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.62 IMPA2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.62 ATP2A2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.62 ATP2A2 DRD3 IMPA2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.62 ATP2A2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.62 DRD3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.62 DRD3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.62 IMPA2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.62 DRD3
19 Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation GR00203-A 9.13 DRD3 RELN SLC6A4

Drugs & Therapeutics for Bipolar Disorder

Drugs for Bipolar Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 490)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamotrigine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84057-84-1 3878
2
Ziprasidone Approved Phase 4,Phase 3,Phase 2,Not Applicable 146939-27-7 60854
3
Lithium carbonate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 554-13-2
4
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 99-66-1 3121
5
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 129722-12-9 60795
6
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 54910-89-3 3386
7
Risperidone Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 106266-06-2 5073
8
Sertraline Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 79617-96-2 68617
9
Topiramate Approved Phase 4,Phase 3,Phase 1 97240-79-4 5284627
10
Methylphenidate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 113-45-1 4158
11
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 132539-06-1 4585
12
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 298-46-4 2554
13
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Not Applicable 616-91-1 12035
14
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
15
Oxcarbazepine Approved Phase 4,Phase 2,Phase 3 28721-07-5 34312
16
Coal tar Approved Phase 4,Phase 2 8007-45-2
17
Bupropion Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 34841-39-9, 34911-55-2 444
18
Ropinirole Approved, Investigational Phase 4 91374-21-9, 91374-20-8 497540 5095
19
Citalopram Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59729-33-8 2771
20
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 61869-08-7 43815
21
Memantine Approved, Investigational Phase 4,Phase 2,Phase 3 19982-08-2 4054
22
Norepinephrine Approved Phase 4,Phase 3,Phase 2 51-41-2 439260
23
Pramipexole Approved, Investigational Phase 4,Phase 2 104632-26-0 119570 59868
24 tannic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
25
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 94-09-7, 1994-09-7 2337
26
Varenicline Approved, Investigational Phase 4,Not Applicable 249296-44-4 5310966
27
Nortriptyline Approved Phase 4 72-69-5 4543
28
Modafinil Approved, Investigational Phase 4,Phase 2 68693-11-8 4236
29
Armodafinil Approved, Investigational Phase 4,Phase 2 112111-43-0
30
Asenapine Approved Phase 4,Phase 3,Phase 2,Phase 1 65576-45-6, 85650-56-2 3001386
31
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 64-17-5 702
32
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 50-36-2 5760 446220
33
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 16590-41-3 5360515
34
Galantamine Approved Phase 4,Phase 3,Not Applicable 357-70-0 9651
35
Clozapine Approved Phase 4,Phase 3,Phase 2,Not Applicable 5786-21-0 2818
36
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
37
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091
38
Tranylcypromine Approved, Investigational Phase 4,Not Applicable 155-09-9 441233
39
Mirtazapine Approved Phase 4 61337-67-5, 85650-52-8 4205
40
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1 51-45-6, 75614-87-8 774
41
Acetylcholine Approved Phase 4,Not Applicable 51-84-3 187
42
Acamprosate Approved, Investigational Phase 4,Phase 1,Phase 2 77337-76-9 71158
43
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 6740-88-1 3821
44
Cycloserine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 68-41-7 6234 401
45
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
46
Donepezil Approved Phase 4 120014-06-4 3152
47
Minocycline Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 10118-90-8 5281021
48
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
49
Chlorpromazine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-53-3 2726
50
Racepinephrine Approved Phase 4 329-65-7 838

Interventional clinical trials:

(show top 50) (show all 1307)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Juvenile Bipolar Disorder Outpatient Program Unknown status NCT01000402 Phase 4 Psychopharmacotherapy
3 Open Label Study of Lithium Plus Extended-Release Carbamazepine (ERC-CBZ) for Rapid Cycling Bipolar Disorder Unknown status NCT00325286 Phase 4 Lithium Plus Extended- Release Carbamazepine
4 Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Disorder Unknown status NCT00608075 Phase 4 lithium;Lithium
5 Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD Unknown status NCT00579280 Phase 4 quetiapine SR;divalproex sodium ER;placebo
6 Efficacy of N-Acetyl-Cysteine in Bipolar Disorder and Tobacco Use Disorder Unknown status NCT02252341 Phase 4
7 Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania Unknown status NCT01893229 Phase 4 Lithium;Valproate;Oxcarbazepine;Quetiapine;Olanzapine;Ziprasidone
8 Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression Unknown status NCT01583023 Phase 4 Bupropion
9 Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia Unknown status NCT00541554 Phase 4 Abilify (aripiprazole)
10 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar Depression. Unknown status NCT00335205 Phase 4 ropinirole
11 Melancholic Symptoms in Bipolar Depression and Responsiveness to Lamotrigine Unknown status NCT02989727 Phase 4 Lamotrigine;Placebos
12 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
13 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
14 Efficacy and Safety of Utapine vs. Seroquel in Patients With Bipolar Mania Unknown status NCT01043679 Phase 4 Utapine;Seroquel
15 Reduction of Cardiovascular Risk in Severe Mental Illness Unknown status NCT01182012 Phase 4
16 Neurophysiologic Changes in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
17 Abilify in Bipolar Disorder for 24 Weeks Treatment Effectiveness Completed NCT00545675 Phase 4 Abilify(aripiprazole);Depakote (divalproate)
18 Targeting Cognition in Bipolar Disorder With Pramipexole Completed NCT02397837 Phase 4 Pramipexole;Placebo
19 Effectiveness of Lithium Plus Optimized Medication in Treating People With Bipolar Disorder Completed NCT00667745 Phase 4 Lithium Carbonate;Optimized Treatment (OPT)
20 Varenicline Treatment for Smoking Cessation in Patients With Bipolar Disorder Completed NCT01010204 Phase 4 Varenicline;Placebo
21 Effect of Oxcarbazepine on Serum Brain Derived Neurotrophic Factor (BDNF) in Bipolar Disorder Completed NCT02456896 Phase 4 Oxcarbazepine
22 Memantine and Cognitive Dysfunction in Bipolar Disorder Completed NCT00586066 Phase 4 Memantine;Placebo
23 Cost- Effectiveness and Quality of Life Assessment in Bipolar Disorder Depressive Episode Completed NCT02918097 Phase 4 Lithium Carbonate;Sertraline;Nortriptyline;Risperidone
24 Olanzapine Compared to Lamotrigine in the Prevention of Depressive Episode in the Patients With Bipolar Disorder Completed NCT01864551 Phase 4 Lamotrigine;Olanzapine
25 Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil Completed NCT01965925 Phase 4 Modafinil;Placebo
26 The Efficacy and Safety of Oral Oxcarbazepine 300-1200 mg/Day as Adjuvant Therapy in the Treatment of Bipolar Disorder I or II This Study is Not Being Conducted in the United States. Completed NCT00154323 Phase 4 Oxcarbazepine
27 Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine Completed NCT00394095 Phase 4 Topiramate;Placebo
28 Safety And Efficacy Study Of Depakote ER To Treat Pediatric Bipolar Disorder Completed NCT00199966 Phase 4 Divalproex sodium extended release
29 Comparative Effectiveness Study for Bipolar Disorder Completed NCT01331304 Phase 4 Lithium;Quetiapine
30 Abilify in Bipolar Disorder for 6 Weeks Treatment Effectiveness Completed NCT00545142 Phase 4 Abilify(Aripiprazole);Depakote(Divalproate)
31 Aripiprazole in Late Life Bipolar Disorder Completed NCT00194038 Phase 4 Aripiprazole
32 Psychosocial Therapy Plus Maintenance Pharmacotherapy for Treating Bipolar Disorder Completed NCT00227968 Phase 4
33 Asenapine in the Treatment of Older Adults With Bipolar Disorder Completed NCT01460290 Phase 4 Asenapine
34 Ziprasidone in Pediatric Bipolar Disorder Completed NCT00622739 Phase 4 Ziprasidone;Ziprasidone
35 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4 Placebo;Quetiapine
36 Ziprasidone Switching in Response to Adherence and Psychotropic-Related Weight Gain Concerns Among Patients With Bipolar Disorder (Zip Ad) Completed NCT01293825 Phase 4 ziprasidone
37 Quetiapine Sr as Adjunctive Treatment In Mixed States of Bipolar Disorder Completed NCT01195363 Phase 4 quetiapine SR;quetiapine sr placebo
38 Quetiapine Fumarate (Seroquel) as Mono-Therapy or Adjunct to Lithium in the Treatment of Patients With Acute Mania in Bipolar Disorder Completed NCT00672490 Phase 4 Quetiapine Fumarate;Lithium
39 Iloperidone in Mixed States of Bipolar Disorder Completed NCT02413918 Phase 4 iloperidone
40 Cognitive Enhancement in Bipolar Disorder Completed NCT00597896 Phase 4 pramipexole
41 An Open-Label Extension Study Of Lamotrigine In Subjects With Bipolar Disorder Completed NCT00360126 Phase 4 lamotrigine
42 Ramelteon for the Treatment of Insomnia and Mood Stability in Patients With Euthymic Bipolar Disorder Completed NCT00552760 Phase 4 Ramelteon;Placebo
43 Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency Completed NCT00280293 Phase 4 Lamotrigine;Placebo
44 Naltrexone for Bipolar Disorder and Alcohol Dependence Completed NCT00223275 Phase 4 Naltrexone
45 Efficacy and Safety of Galantamine for Improving Dysfunction in People With Bipolar Disorder Completed NCT00741598 Phase 4 Galantamine-ER;Galantamine placebo
46 Lamictal As Add on Treatment in Mixed States of Bipolar Disorder Completed NCT00223509 Phase 4 Lamotrigine
47 FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder Completed NCT00596622 Phase 4 Lithium
48 Geodon in Weight Loss Study for Bipolar Disorders Completed NCT00472641 Phase 4 Ziprasidone/Geodon
49 Valproic Acid Sodium Salt in Bipolar Disorder Completed NCT00431522 Phase 4 Valproic acid, sodium salt
50 Metabolic Effects of Switching to Aripiprazole in Patients With Bipolar Disorders Completed NCT00845988 Phase 4 aripiprazole

Search NIH Clinical Center for Bipolar Disorder

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: bipolar disorder

Genetic Tests for Bipolar Disorder

Anatomical Context for Bipolar Disorder

MalaCards organs/tissues related to Bipolar Disorder:

41
Brain, Testes, Cortex, Prefrontal Cortex, Eye, Amygdala, Cingulate Cortex

Publications for Bipolar Disorder

Articles related to Bipolar Disorder:

(show top 50) (show all 3821)
# Title Authors Year
1
Correlation between depression/anxiety symptom severity and quality of life in patients with major depressive disorder or bipolar disorder. ( 30292023 )
2019
2
The impact of COMT polymorphisms on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders. ( 30146088 )
2019
3
Attention deficit-hyperactivity disorder in adult bipolar disorder patients. ( 30267955 )
2019
4
Impulsivity and its association with childhood trauma experiences across bipolar disorder, attention deficit hyperactivity disorder and borderline personality disorder. ( 30336349 )
2019
5
Nonlinear Indices with Applications to Schizophrenia and Bipolar Disorder. ( 30557135 )
2019
6
Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives. ( 30248494 )
2019
7
Bipolar disorder and psychotropic medication: Impact on pregnancy and neonatal outcomes. ( 30248632 )
2019
8
Nonlinear dynamics of mood regulation in unaffected first-degree relatives of bipolar disorder patients. ( 30248639 )
2019
9
Gut microbiota composition in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives. ( 30261302 )
2019
10
Seasonality in bipolar disorder: Effect of sex and age. ( 30261447 )
2019
11
Inflammation associated with volume reduction in the gray matter and hippocampus of older patients with bipolar disorder. ( 30317016 )
2019
12
Oligopeptidases activity in bipolar disorder: Ndel1 and angiotensin I converting enzyme. ( 30321766 )
2019
13
Glutamate-Related Antibodies and Peripheral Insulin-Like Growth Factor in Bipolar Disorder and Lithium Prophylaxis. ( 30336492 )
2019
14
Effects of childhood trauma on adult moral decision-making: Clinical correlates and insights from bipolar disorder. ( 30343121 )
2019
15
Lithium interacts with cardiac remodeling: the fundamental value in the pharmacotherapy of bipolar disorder. ( 30053574 )
2019
16
The impact of BDNF Val66Met polymorphism on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders. ( 30078664 )
2019
17
Genetic basis of psychopathological dimensions shared between schizophrenia and bipolar disorder. ( 30149091 )
2019
18
Capacity to provide informed consent among adults with bipolar disorder. ( 30153563 )
2019
19
Association between completed suicide and bipolar disorder: A systematic review of the literature. ( 30173059 )
2019
20
Phenomenology and diagnostic stability of paediatric bipolar disorder in a Spanish sample. ( 30205288 )
2019
21
Associations of the serotonin transporter promoter polymorphism (5-HTTLPR) with bipolar disorder and treatment response: A systematic review and meta-analysis. ( 30217771 )
2019
22
MRI features of clinical outcome in bipolar disorder: A selected review: Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders. ( 29907266 )
2019
23
Theory of mind in remitted bipolar disorder: Younger patients struggle in tasks of higher ecological validity. ( 29428351 )
2018
24
Genetic polymorphisms associated with circadian rhythm dysregulation provide new perspectives on bipolar disorder. ( 29441659 )
2018
25
Newly Diagnosed Bipolar Disorder and the Subsequent Risk of Erectile Dysfunction: A Nationwide Cohort Study. ( 29425665 )
2018
26
Pharmacological treatment for schizoaffective disorder : A comparison with schizophrenia and bipolar disorder. ( 29564469 )
2018
27
The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis. ( 29759891 )
2018
28
Prevalence of childhood trauma and correlations between childhood trauma, suicidal ideation, and social support in patients with depression, bipolar disorder, and schizophrenia in southern China. ( 29223913 )
2018
29
The use of a Gene Expression Signature and Connectivity Map to repurpose drugs for Bipolar Disorder. ( 29956574 )
2018
30
Cognitive control under stressful conditions in transitional age youth with bipolar disorder: Diagnostic and sleep-related differences in fronto-limbic activation patterns. ( 29441653 )
2018
31
Mitochondrial Complex I Deficiency in Schizophrenia and Bipolar Disorder and Medication Influence. ( 29594135 )
2018
32
Metabolic risk factors in schizophrenia and bipolar disorder: The effect of comedication with selective serotonin reuptake inhibitors and antipsychotics. ( 29331603 )
2018
33
ADHD-juvenile bipolar disorder: mimics and chameleons! ( 29446039 )
2018
34
Prevalence of cognitive impairment in major depression and bipolar disorder. ( 29345037 )
2018
35
Decreased anterior cingulate activation in a motor task in youths with bipolar disorder. ( 29451300 )
2018
36
Meta-analysis of regional white matter volume in bipolar disorder with replication in an independent sample using coordinates, T-maps, and individual MRI data. ( 29162519 )
2018
37
The 'new normal': relativity of quality of life judgments in individuals with bipolar disorder-a qualitative study. ( 29435800 )
2018
38
Telomere Length and Bipolar Disorder. ( 29230034 )
2018
39
Influence of gender on inpatient treatment for bipolar disorder: An analysis of 60,607 hospitalisations. ( 28810176 )
2018
40
Elevated heat shock proteins in bipolar disorder patients with hypothalamic pituitary adrenal axis dysfunction. ( 29979378 )
2018
41
Case series of diagnostic shift from bipolar disorder to schizoaffective disorder. ( 29189086 )
2018
42
Morningness-Eveningness questionnaire in bipolar disorder. ( 29427910 )
2018
43
Early Intervention in Bipolar Disorder. ( 29361850 )
2018
44
Resting-state functional connectivity in individuals with bipolar disorder during clinical remission: a systematic review. ( 29952748 )
2018
45
Psychosis in bipolar disorder: Does it represent a more "severe" illness? ( 28833984 )
2018
46
Electroencephalographic delta/alpha frequency activity differentiates psychotic disorders: a study of schizophrenia, bipolar disorder and methamphetamine-induced psychotic disorder. ( 29643331 )
2018
47
Elevated interleukin-17 and reduced testosterone in bipolar disorder. Relation with suicidal behaviour. ( 29979995 )
2018
48
Bipolar Disorder and Heart Transplantation: A Case Report. ( 29428124 )
2018
49
The differential association between history of childhood sexual abuse and body mass index in early and late stages of bipolar disorder. ( 29102835 )
2018
50
Does the course of manic symptoms in pediatric bipolar disorder impact the course of conduct disorder? Findings from four prospective datasets. ( 29890451 )
2018

Variations for Bipolar Disorder

Copy number variations for Bipolar Disorder from CNVD:

7 (show top 50) (show all 399)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 13918 1 100964950 101093664 Deletion Bipolar disorder
2 13959 1 101777242 101789688 Copy number Bipolar disorder
3 14276 1 106411328 106634702 Copy number Bipolar disorder
4 15012 1 111824223 111936532 Deletion Bipolar disorder
5 15144 1 112987422 113369070 Deletion Bipolar disorder
6 15198 1 113388739 114043773 Deletion Bipolar disorder
7 15265 1 114105331 114260861 Deletion Bipolar disorder
8 15293 1 114379103 114611497 Deletion Bipolar disorder
9 15315 1 114627212 115118807 Deletion Bipolar disorder
10 17285 1 142400000 148000000 Deletion Bipolar disorder
11 17371 1 142600000 147000000 Copy number Bipolar disorder
12 17555 1 14341488 14762438 Deletion Bipolar disorder
13 18108 1 144093481 144503421 Deletion Bipolar disorder
14 21577 1 159722810 159884140 Copy number FCGR2A Bipolar disorder
15 21578 1 159722810 159884140 Copy number FCGR2C Bipolar disorder
16 21579 1 159722810 159884140 Copy number FCGR3A Bipolar disorder
17 21580 1 159722810 159884140 Copy number FCGR3B Bipolar disorder
18 21581 1 159722810 159884140 Copy number HSPA6 Bipolar disorder
19 24355 1 179082079 179207535 Deletion Bipolar disorder
20 27840 1 214001144 214182688 Deletion Bipolar disorder
21 30012 1 239069843 239226340 Deletion Bipolar disorder
22 30852 1 246404335 246667943 Deletion Bipolar disorder
23 30991 1 247034191 247138092 Deletion Bipolar disorder
24 31736 1 30336050 30952188 Deletion Bipolar disorder
25 34240 1 53925291 53984359 Copy number GLIS1 Bipolar disorder
26 35075 1 59854502 60323099 Deletion Bipolar disorder
27 35289 1 62052182 62289893 Deletion Bipolar disorder
28 35722 1 66557267 66646247 Copy number PDE4B Bipolar disorder
29 35951 1 696962 803181 Deletion Bipolar disorder
30 37047 1 84784450 84864145 Copy number CTBS Bipolar disorder
31 37048 1 84784450 84864145 Copy number SPATA1 Bipolar disorder
32 37147 1 85996510 86164671 Deletion Bipolar disorder
33 38265 10 10058972 10215130 Deletion Bipolar disorder
34 39159 10 111195021 111323778 Deletion Bipolar disorder
35 39762 10 119100000 135374737 Deletion Bipolar disorder
36 40469 10 128361479 128559816 Deletion Bipolar disorder
37 42381 10 32899498 33000799 Deletion Bipolar disorder
38 42648 10 37554667 37710375 Deletion Bipolar disorder
39 43112 10 44523027 44679489 Copy number Bipolar disorder
40 43587 10 47013328 47173619 Copy number Bipolar disorder
41 44374 10 56148428 56359760 Deletion Bipolar disorder
42 47196 10 90344868 90556337 Deletion Bipolar disorder
43 47223 10 90559662 90957411 Deletion Bipolar disorder
44 49063 11 102652001 102778728 Deletion Bipolar disorder
45 50159 11 114721884 114868905 Deletion Bipolar disorder
46 51811 11 131159857 131261275 Deletion Bipolar disorder
47 51869 11 132518807 132864395 Deletion Bipolar disorder
48 51963 11 133786141 134449982 Deletion Bipolar disorder
49 53165 11 25250128 26084796 Deletion Bipolar disorder
50 53245 11 26949271 27197653 Deletion Bipolar disorder

Expression for Bipolar Disorder

Search GEO for disease gene expression data for Bipolar Disorder.

Pathways for Bipolar Disorder

GO Terms for Bipolar Disorder

Biological processes related to Bipolar Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphate-containing compound metabolic process GO:0006796 9.37 IMPA1 IMPA2
2 response to pain GO:0048265 9.32 COMT RELN
3 dopamine metabolic process GO:0042417 9.26 COMT DRD3
4 inositol phosphate dephosphorylation GO:0046855 9.16 IMPA1 IMPA2
5 learning GO:0007612 9.13 COMT DRD3 RELN
6 inositol biosynthetic process GO:0006021 8.62 IMPA1 IMPA2

Molecular functions related to Bipolar Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inositol monophosphate 1-phosphatase activity GO:0008934 9.26 IMPA1 IMPA2
2 inositol monophosphate 3-phosphatase activity GO:0052832 9.16 IMPA1 IMPA2
3 inositol monophosphate 4-phosphatase activity GO:0052833 8.96 IMPA1 IMPA2
4 inositol monophosphate phosphatase activity GO:0052834 8.62 IMPA1 IMPA2

Sources for Bipolar Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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