Bipolar Disorder

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Bipolar Disorder

MalaCards integrated aliases for Bipolar Disorder:

Name: Bipolar Disorder 12 73 20 43 36 54 42 44 15 17 70
Major Affective Disorder 20 39 70
Bipolar Affective Disorder 20 43
Depression, Bipolar 43 70
Bipolar Depression 12 15
Manic Depression 12 20
Manic Disorder 12 70
Manic Bipolar Affective Disorder 12
Bipolar Disorder Manic Phase 12
Bipolar Affective Psychosis 43
Major Affective Disorder 1 70
Manic-Depressive Psychosis 20
Major Affective Disorder 2 70
Manic Depressive Disorder 12
Bipolar Spectrum Disorder 43
Manic Bipolar I Disorder 12
Manic Depressive Illness 43
Affective Disorder Major 54
Depressive-Manic Psych. 12
Bipolar Disorder, Mixed 70
Mixed Bipolar Disorder 12
Depression Bipolar 54
Bipolar Illness 20


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Disease Ontology 12 DOID:3312
KEGG 36 H01653
MeSH 44 D001714
ICD10 32 F31
UMLS 70 C0005586 C0005587 C0024713 more

Summaries for Bipolar Disorder

MedlinePlus : 42 What is bipolar disorder? Bipolar disorder is a mood disorder that can cause intense mood swings: Sometimes you may feel extremely "up," elated, irritable, or energized. This is called a manic episode. Other times you may feel "down," sad, indifferent, or hopeless. This is called a depressive episode. You may have both manic and depressive symptoms together. This is called a mixed episode. Along with the mood swings, bipolar disorder causes changes in behavior, energy levels, and activity levels. Bipolar disorder used to be called other names, including manic depression and manic-depressive disorder. What are the types of bipolar disorder? There are three main types of bipolar disorder: Bipolar I disorder involves manic episodes that last at least 7 days or manic symptoms so severe that you need immediate hospital care. Depressive episodes are also common. Those often last at least two weeks. This type of bipolar disorder can also involve mixed episodes. Bipolar II disorder involves depressive episodes. But instead of full-blown manic episodes, there are episodes of hypomania. Hypomania is a less severe version of mania. Cyclothymic disorder, or cyclothymia, also involves hypomanic and depressive symptoms. But they are not as intense or as long-lasting as hypomanic or depressive episodes. The symptoms usually last for at least two years in adults and for one year in children and teenagers. With any of these types, having four or more episodes of mania or depression in a year is called "rapid cycling." What causes bipolar disorder? The exact cause of bipolar disorder is unknown. Several factors likely play a role in the disorder. They include genetics, brain structure and function, and your environment. Who is at risk for bipolar disorder? You are at higher risk for bipolar disorder if you have a close relative who has it. Going through trauma or stressful life events may raise this risk even more. What are the symptoms of bipolar disorder? The symptoms of bipolar disorder can vary. But they involve mood swings known as mood episodes: The symptoms of a manic episode can include Feeling very up, high, or elated Feeling jumpy or wired, more active than usual Having a very short temper or seeming extremely irritable Having racing thoughts and talking very fast Needing less sleep Feeling like you are unusually important, talented, or powerful Do risky things that show poor judgment, such as eating and drinking too much, spending or giving away a lot of money, or having reckless sex The symptoms of a depressive episode can include Feeling very sad, hopeless, or worthless Feeling lonely or isolating yourself from others Talking very slowly, feeling like you have nothing to say, or forgetting a lot Having little energy Sleeping too much Eating too much or too little Lack of interest in your usual activities and being unable to do even simple things Thinking about death or suicide The symptoms of a mixed episode include both manic and depressive symptoms together. For example, you may feel very sad, empty, or hopeless, while at the same time feeling extremely energized. Some people with bipolar disorder may have milder symptoms. For example, you may have hypomania instead of mania. With hypomania, you may feel very good and find that you can get a lot done. You may not feel like anything is wrong. But your family and friends may notice your mood swings and changes in activity levels. They may realize that your behavior is unusual for you. After the hypomania, you might have severe depression. Your mood episodes may last a week or two or sometimes longer. During an episode, symptoms usually occur every day for most of the day. How is bipolar disorder diagnosed? To diagnose bipolar disorder, your health care provider may use many tools: A physical exam A medical history, which will include asking about your symptoms, lifetime history, experiences, and family history Medical tests to rule out other conditions A mental health evaluation. Your provider may do the evaluation or may refer you to a mental health specialist to get one. What are the treatments for bipolar disorder? Treatment can help many people, including those with the most severe forms of bipolar disorder. The main treatments for bipolar disorder include medicines, psychotherapy, or both: Medicines can help control the symptoms of bipolar disorder. You may need to try several different medicines to find which one works best for you. Some people need to take more than one medicine. It's important to take your medicine consistently. Don't stop taking it without first talking with your provider. Contact your provider if you have any concerns about side effects from the medicines. Psychotherapy (talk therapy) can help you recognize and change troubling emotions, thoughts, and behaviors. It can give you and your family support, education, skills, and coping strategies. There are several different types of psychotherapy that may help with bipolar disorder. Other treatment options include Electroconvulsive therapy (ECT), a brain stimulation procedure that can help relieve symptoms. ECT is most often used for severe bipolar disorder that is not getting better with other treatments. It may also be used when someone needs a treatment that will work more quickly than medicines. This might be when a person has a high risk of suicide or is catatonic (unresponsive). Getting regular aerobic exercise may help with depression, anxiety, and trouble sleeping Keeping a life chart can help you and your provider track and treat your bipolar disorder. A life chart is a record of your daily mood symptoms, treatments, sleep patterns, and life events. Bipolar disorder is a lifelong illness. But long-term, ongoing treatment can help manage your symptoms and enable you to live a healthy, successful life. NIH: National Institute of Mental Health

MalaCards based summary : Bipolar Disorder, also known as major affective disorder, is related to schizophrenia and mood disorder. An important gene associated with Bipolar Disorder is DISC2 (Disrupted In Schizophrenia 2), and among its related pathways/superpathways are Neurotransmitter Clearance In The Synaptic Cleft and Methylphenidate Pathway, Pharmacodynamics. The drugs Eleuthero and Dextroamphetamine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and prefrontal cortex.

Disease Ontology : 12 A mood disorder that involves alternating periods of mania and depression.

MedlinePlus Genetics : 43 Bipolar disorder is a mental health condition that causes extreme shifts in mood, energy, and behavior. This disorder most often appears in late adolescence or early adulthood, although symptoms can begin at any time of life.People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes. These episodes can last from hours to weeks, and many people have no symptoms between episodes.Manic episodes are characterized by increased energy and activity, irritability, restlessness, an inability to sleep, and reckless behavior. Some people with bipolar disorder experience hypomanic episodes, which are similar to but less extreme than manic episodes.Depressive episodes are marked by low energy and activity, a feeling of hopelessness, and an inability to perform everyday tasks. People with bipolar disorder often have repeated thoughts of death and suicide, and they have a much greater risk of dying by suicide than the general population.Manic and depressive episodes can include psychotic symptoms, such as false perceptions (hallucinations) or strongly held false beliefs (delusions). Mixed episodes, which have features of manic and depressive episodes at the same time, also occur in some affected individuals.Bipolar disorder is classified into several types based on the mood changes that occur. Bipolar I involves manic episodes, which can be accompanied by psychotic symptoms, and hypomanic or depressive episodes. Bipolar II involves hypomanic episodes and depressive episodes. Cyclothymic disorder involves hypomanic episodes and depressive episodes that are typically less severe than those in bipolar I or bipolar II.Bipolar disorder often occurs with other mental health conditions, including anxiety disorders (such as panic attacks), behavioral disorders (such as attention-deficit/hyperactivity disorder), and substance abuse.

GARD : 20 Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. Signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). Mood episodes may also include symptoms of both mania and depression (a mixed state). It often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. Bipolar disorder can run in families, although no single gene is thought to cause the condition. Many factors acting together likely increase a person's risk to develop the disorder. Treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms.

KEGG : 36 Bipolar disorder, previously known as manic depressive illness, is a severe chronic mood disorder, characterized by the recurrence of mania (hypomania), depression, or mixed episodes. It is one of the main causes of disability among young people, leading to cognitive and functional impairment and raised mortality, particularly death by suicide. Mania is the most characteristic phase of bipolar disorder. While mood elevation and euphoria are commonly described phenotypic descriptors of mania, irritability and anger may dominate. At the present time, there is solid evidence supporting the use of lithium, the anticonvulsants valproate and carbamazepine, and some antipsychotics in mania. Manic or hypomanic episodes differ in severity and length. In a hypomanic episode, a disturbance in functioning can be seen by others but does not typically cause severe impairment or require admission to hospital. At onset, most patients with bipolar disorder present with a depressive episode that differs subtly from unipolar depression. The first step in the management of bipolar disorder is to confirm the diagnosis of mania or hypomania and define the patient's mood state, because the therapeutic approach differs considerably for hypomania, mania, depression, and euthymia. While effective pharmacological treatments exist for bipolar disorder, the pathophysiology of the condition essentially remains unknown. Although bipolar disorder is one of the most heritable psychiatric disorders, a multifactorial model in which gene and environment interact is currently thought to best fit this disorder. Many risk alleles of small effect which are described in genome-wide association studies, contribute to the polygenic risk of bipolar disorder. It is suggested that the dopaminergic system may play a central role in bipolar disorder, although no singular dysfunction of neurotransmitter systems has been identified.

Wikipedia : 73 Bipolar disorder, previously known as manic depression, is a mental disorder characterized by periods of... more...

Related Diseases for Bipolar Disorder

Diseases in the Bipolar Disorder family:

Bipolar Ll Disorder Bipolar I Disorder

Diseases related to Bipolar Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 712)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 33.5 SLC6A4 RELN PRODH DRD3 DISC2 DISC1
2 mood disorder 33.4 SLC6A4 RELN PRODH IMPA1 DRD3 DISC2
3 major depressive disorder 33.3 SLC6A4 DRD3 DISC2 DISC1 COMT BDNF
4 schizoaffective disorder 33.3 SLC6A4 RELN PRODH DRD3 DISC2 DISC1
5 bipolar i disorder 33.2 SLC6A4 COMT BDNF
6 psychotic disorder 33.1 SLC6A4 RELN PRODH DRD3 DISC1 DAOA
7 depression 33.1 SLC6A4 RELN DISC2 BDNF
8 mental depression 32.9 SLC6A4 PRODH DISC1 COMT BDNF
9 cyclothymic disorder 32.8 SLC6A4 DISC1 DAOA COMT
10 migraine with or without aura 1 32.7 SLC6A4 DRD3 COMT BDNF
11 attention deficit-hyperactivity disorder 32.6 SLC6A4 PRODH DRD3 COMT BDNF
12 substance abuse 32.6 SLC6A4 PRODH DRD3 COMT BDNF
13 asperger syndrome 32.6 SLC6A4 DISC1 COMT BDNF
14 personality disorder 32.6 SLC6A4 DRD3 COMT BDNF
15 tardive dyskinesia 32.5 DRD3 COMT
16 endogenous depression 32.5 SLC6A4 COMT BDNF
17 anxiety 32.5 SLC6A4 PRODH DISC1 COMT BDNF
18 schizophrenia 9 32.4 PRODH DISC1
19 alcohol use disorder 32.4 SLC6A4 PRODH DRD3 COMT BDNF
20 panic disorder 32.3 SLC6A4 DRD3 DAOA-AS1 DAOA COMT BDNF
21 borderline personality disorder 32.2 SLC6A4 COMT BDNF
22 schizophrenia 2 32.2 PRODH DISC2 DISC1
23 obsessive-compulsive disorder 32.2 SLC6A4 DRD3 COMT BDNF
24 alcohol dependence 32.2 SLC6A4 DRD3 COMT BDNF
25 eating disorder 32.1 SLC6A4 DRD3 COMT BDNF
26 post-traumatic stress disorder 32.1 SLC6A4 COMT BDNF
27 autism 32.0 SLC6A4 RELN PRODH DRD3 DISC1 COMT
28 generalized anxiety disorder 31.9 SLC6A4 COMT BDNF
29 disease of mental health 31.9 SLC6A4 RELN PRODH IMPA1 DRD3 DISC2
30 substance dependence 31.9 SLC6A4 DRD3 COMT BDNF
31 autism spectrum disorder 31.9 SLC6A4 RELN PRODH DRD3 DISC2 DISC1
32 social phobia 31.8 SLC6A4 PRODH COMT BDNF
33 tobacco addiction 31.7 SLC6A4 DRD3 COMT BDNF
34 sleep disorder 31.7 SLC6A4 PRODH COMT BDNF
35 postpartum depression 31.6 SLC6A4 COMT BDNF
36 acute stress disorder 31.6 SLC6A4 BDNF
37 neurotic disorder 31.6 SLC6A4 COMT BDNF
38 cocaine dependence 31.5 SLC6A4 DRD3 COMT BDNF
39 pervasive developmental disorder 31.5 SLC6A4 RELN PRODH DISC1 BDNF
40 dysthymic disorder 31.5 SLC6A4 PRODH COMT BDNF
41 cannabis abuse 31.5 PRODH COMT BDNF
42 phobia, specific 31.5 SLC6A4 PRODH COMT BDNF
43 movement disease 31.4 PRODH DRD3 COMT BDNF
44 fibromyalgia 31.4 SLC6A4 COMT BDNF
45 traumatic brain injury 31.4 COMT BDNF
46 bulimia nervosa 31.4 SLC6A4 COMT BDNF
47 gilles de la tourette syndrome 31.4 SLC6A4 DRD3 COMT BDNF
48 atypical depressive disorder 31.3 SLC6A4 BDNF
49 paranoid schizophrenia 31.3 SLC6A4 DISC1 COMT BDNF
50 irritable bowel syndrome 31.3 SLC6A4 COMT BDNF

Comorbidity relations with Bipolar Disorder via Phenotypic Disease Network (PDN):

Acute Cystitis Diabetes Insipidus, Nephrogenic, Autosomal
Hypertension, Essential Hypothyroidism
Major Affective Disorder 9 Major Depressive Disorder
Parkinson Disease, Late-Onset Schizophrenia
Schizophreniform Disorder Tardive Dyskinesia

Graphical network of the top 20 diseases related to Bipolar Disorder:

Diseases related to Bipolar Disorder

Symptoms & Phenotypes for Bipolar Disorder

Drugs & Therapeutics for Bipolar Disorder

Drugs for Bipolar Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 426)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Eleuthero Approved, Experimental Phase 4
Dextroamphetamine Approved, Illicit Phase 4 51-64-9 5826
Coal tar Approved Phase 4 8007-45-2
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
Pramipexole Approved, Investigational Phase 4 104632-26-0 59868 119570
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
Donepezil Approved Phase 4 120014-06-4 3152
Cocaine Approved, Illicit Phase 4 50-36-2 446220 5760
Clozapine Approved Phase 4 5786-21-0 2818
Loxapine Approved Phase 4 1977-10-2 3964
Sertraline Approved Phase 4 79617-96-2 68617
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
Norepinephrine Approved Phase 4 51-41-2 439260
Inositol Approved, Investigational, Withdrawn Phase 4 87-89-8
Asenapine Approved Phase 4 85650-56-2, 65576-45-6 3001386
Levetiracetam Approved Phase 4 102767-28-2 441341
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
Oxcarbazepine Approved Phase 4 28721-07-5 34312
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
Methohexital Approved Phase 4 151-83-7 9034
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
Topiramate Approved Phase 4 97240-79-4 5284627
Galantamine Approved Phase 4 357-70-0 9651
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 497540 5095
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
Nortriptyline Approved Phase 4 72-69-5 4543
Iloperidone Approved Phase 4 133454-47-4 71360
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
Ondansetron Approved Phase 4 99614-02-5 4595
Chlorpromazine Approved, Investigational, Vet_approved Phase 4 50-53-3 2726
Sibutramine Approved, Illicit, Investigational, Withdrawn Phase 4 106650-56-0 5210
Dipyridamole Approved Phase 4 58-32-2 3108
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
Atorvastatin Approved Phase 4 134523-00-5 60823
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
Metformin Approved Phase 4 657-24-9 4091 14219
Nicotine Approved Phase 4 54-11-5 942 89594
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
Racepinephrine Approved Phase 4 329-65-7 838
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198

Interventional clinical trials:

(show top 50) (show all 1282)
# Name Status NCT ID Phase Drugs
1 Exploring Alterations of Central Autonomic Modulation in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
2 Assessing the Efficacy of Left Repetitive Transcranial Magnetic Stimulation (rTMS) as an Adjunctive Treatment to Mood Stabilizers for the Treatment of Bipolar Depression Unknown status NCT01583023 Phase 4 Bupropion
3 Algorithm Guided Treatment Strategies for Bipolar Depression Unknown status NCT01938859 Phase 4 Lithium;Quetiapine;Shuganjieyu capsule
4 Clinical Psychopharmacology Division Institute of Mental Health, Peking University Unknown status NCT03148535 Phase 4 Lithium Carbonate;lithium carbonate combined with SSRI antidepressant treatment
5 A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression Unknown status NCT02719392 Phase 4 Minocycline
6 An Exploratory Randomized Open Comparison of Oxtellar XR® vs Oxcarbazepine IR (Trileptal®) for the Treatment of Bipolar Depression Unknown status NCT03567681 Phase 4 Extended release oxcarbazepine vs Immediate release oxcarbazepine
7 A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders Unknown status NCT01742390 Phase 4 Aripiprazole;risperidone or paliperidone
8 Neuroimaging Study of Risk Factors for Adolescent Bipolar Disorder Unknown status NCT02478788 Phase 4 mixed amphetamine salts-extended release (MAS-XR);Placebo
9 Open Label Prophylaxis Study of Lithium Plus Extended- Release Carbamazepine (Equetro®) Combination for Rapid Cycling Bipolar Disorder Unknown status NCT00325286 Phase 4 Lithium Plus Extended- Release Carbamazepine
10 Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Disorder Unknown status NCT00608075 Phase 4 lithium;Lithium
11 An Open Label, Multicenter, Single Arm, 4-Week Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
12 Assessment and Follow Up Study of Children and Adolescent With Bipolar Disorder Unknown status NCT01000402 Phase 4 Psychopharmacotherapy
13 A Randomized Controlled Trial to Evaluate the Effectiveness of Clozapine Versus Olanzapine, Quetiapine or Risperidone in Treatment Resistant Bipolar Disorder Unknown status NCT02562287 Phase 4 Clozapine;Risperidone;Olanzapine;Quetiapine
14 Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia by Aripiprazole Add-on Therapy in the Treatment of Schizophrenia and Bipolar Disorder: An Open-Label Trial Unknown status NCT00541554 Phase 4 Abilify (aripiprazole)
15 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar I and II Depression. Unknown status NCT00335205 Phase 4 ropinirole
16 Comparative Efficacy and Acceptability of Lithium, Valproate, Oxcarbazepine, Quetiapine, Olanzapine, and Ziprasidone in Bipolar I Disorder, Manic or Mixed Phase Unknown status NCT01893229 Phase 4 Lithium;Valproate;Oxcarbazepine;Quetiapine;Olanzapine;Ziprasidone
17 Effects of N-Acetyl-Cysteine on Oxidative Stress Biomarkers in Bipolar Patients With and Without Tobacco Use Disorder Unknown status NCT02252341 Phase 4
18 Reduction of Cardiovascular Risk in Severe Mental Illness Prescribing and Using Better and More Appropriated Drugs Unknown status NCT01182012 Phase 4
19 A Randomized Open-label Active-controlled Study to Evaluate the Efficacy and Safety of Utapine Versus Seroquel in Patients With Bipolar Mania Unknown status NCT01043679 Phase 4 Utapine;Seroquel
20 A Randomized, Open-label, Trial of Lithium Versus Paroxetine in Subjects With Major Depression Who Have a Family History of Bipolar Disorder or Completed Suicide Completed NCT01416220 Phase 4 Lithium;Paroxetine
21 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4 Placebo;Quetiapine
22 Minocycline for Bipolar Disorder Completed NCT01514422 Phase 4 Minocycline
23 Carbamazepine Extended-Release for the Treatment of Bipolar Depression Completed NCT00203567 Phase 4 carbamazepine ER
24 A Phase IV, Multi-center, Double-blind, Double-dummy, Randomized, Parallel-group Study to Compare the Tolerability of Quetiapine Fumarate Immediate Release (Seroquel IR) With Quetiapine Fumarate Extended Release (Seroquel XR) During Initial Dose Escalation in Patients With Bipolar Depression Completed NCT00926393 Phase 4 Quetiapine Immediate Release;Quetiapine Extended Release
25 Open-Label Study of Ziprasidone for the Treatment of Mania in Children and Adolescents With Bipolar Spectrum Disorder Completed NCT00181922 Phase 4 ziprasidone (Geodon)
26 Open-Label Study of Divalproex Sodium Extended Release for the Treatment of Mania in Children Ages 6-12 With Bipolar I, Bipolar II, and Bipolar Spectrum Disorder Completed NCT00181727 Phase 4 divalproex sodium extended release
27 Open-Label Study of Concerta in the Treatment of ADHD in Youth and Adults With Bipolar I, Bipolar II, and Bipolar Spectrum Disorder Completed NCT00181987 Phase 4 methylphenidate HCl (Concerta)
28 Open-Label Comparative Study of Risperidone Versus Olanzapine for Mania in Preschool Children 4 to 6 Years of Age With Bipolar Spectrum Disorder Completed NCT00181935 Phase 4 risperidone (Risperdal);olanzapine (Zyprexa)
29 Open-Label Study of Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar and Bipolar Spectrum Disorder Completed NCT00181883 Phase 4 quetiapine
30 Open-Label Study of Equetro for the Treatment of Mania in Children Ages 6-12 With Bipolar I, Bipolar II, and Bipolar Spectrum Disorder Completed NCT00181870 Phase 4 carbamazepine ER (Equetro)
31 Open-Label Pilot Study of Aripiprazole for the Treatment of Mania in Children and Adolescents With Bipolar I, Bipolar II, and Bipolar Spectrum Disorder Completed NCT00181779 Phase 4 aripiprazole (Abilify)
32 A Pilot Open Study of the Safety and Effectiveness of Lamotrigine for the Treatment of Mania in Youth Ages 6-17 With Bipolar I, Bipolar II, and Bipolar Spectrum Disorders Completed NCT00181844 Phase 4 lamotrigine
33 Metabolic Effects of Melatonin in Patients Treated With Second Generation Antipsychotics Completed NCT01811160 Phase 4 Melatonin;Placebo
34 A Double-Blind, Placebo-Controlled Evaluation of The Efficacy and Safety of AChE Inhibitor Donepezil As Adjunctive Treatment to Mood Stabilizers in Acute Mania Completed NCT01191918 Phase 4 Donepezil and Lithium;Placebo plus Lithium
35 A Randomized, Double-Blind, Placebo-Controlled Add-On Trial of Quetiapine in Patients With Bipolar Disorder and Cocaine Dependence Completed NCT00223210 Phase 4 Quetiapine;PLacebo
36 Lamictal for Use in Treatment of Bipolar Disorder In Adults. A Practical Clinical Assessment of Tolerability and Clinical Effectiveness. Completed NCT00067938 Phase 4 lamotrigine
37 An Open-labeled, Parallel-group, Single-blinded (Rater) Pilot Study to Investigate the Neuroprotective Effects of of Low-dose Lithium in Young Subjects at Ultra High Risk (UHR) of Developing a First-episode Psychotic Disorder Completed NCT00202306 Phase 4 lithium carbonate
38 A Phase IV, Open-label, Non-randomized, Clinical Trial to Evaluate the Safety of Self-administered ADASUVE® (Staccato Loxapine for Inhalation) in Agitated Patients Outside the Hospital Setting Completed NCT02525991 Phase 4
39 Extended Duration Pharmacotherapy for Prevention of Relapse to Smoking Completed NCT00621777 Phase 4 Varenicline;Placebo
40 Longitudinal Study on the Neuroprotective and Neurotrophic Effects of Lithium in Bipolar Disorder: Identification of Cellular and Molecular Targets Clinically Relevant Completed NCT01919892 Phase 4 Lithium
41 Metformin for Treatment Antipsychotic-induced Metabolic Syndrome in Bipolar Disorder Patients Completed NCT02644577 Phase 4 Metformin
42 Acute Antidepressant Therapy in Bipolar II Major Depression Completed NCT00641927 Phase 4 Venlafaxine;Lithium Carbonate
43 Depakote ER in Bipolar Depression Completed NCT00186186 Phase 4 Depakote ER
44 Bipolar Depression Assessment Study on Tx Response Completed NCT00191399 Phase 4 Olanzapine;Fluoxetine
45 An Investigation of Sleep Architecture in Ziprasidone-Treated Bipolar Depression Completed NCT00835107 Phase 4 ziprasidone hydrochloride;placebo
46 A Randomized, Sham Controlled, Crossover Trial of rTMS for Bipolar Depression Completed NCT00186758 Phase 4
47 A Randomized Controlled Trial of Inositol and Omega-3 Fatty Acids in Pediatric Mania Completed NCT01396486 Phase 4 Omega-3;Inositol
48 Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging Completed NCT02473250 Phase 4 Fluoxetine;Citalopram
49 NMDA Antagonists in Bipolar Depression Completed NCT01833897 Phase 4 Standard of Care;Ketamine;D-cycloserine
50 Open-Label Study of N-Acetylcysteine in Children and Adolescents Ages 5-17 With Bipolar I, Bipolar II, and Bipolar Spectrum Disorder Completed NCT02357290 Phase 4 Open-label Treatment with N-Acetylcysteine

Search NIH Clinical Center for Bipolar Disorder

Inferred drug relations via UMLS 70 / NDF-RT 51 :

Divalproex Sodium
gabapentin enacarbil
Lithium Aspartate
Lithium Carbonate
lithium citrate
Mylan brand of clozapine
Quetiapine fumarate
Sodium Valproate
Tiagabine hydrochloride
UDL brand of clozapine
Valproic Acid

Cochrane evidence based reviews: bipolar disorder

Genetic Tests for Bipolar Disorder

Anatomical Context for Bipolar Disorder

MalaCards organs/tissues related to Bipolar Disorder:

Cortex, Brain, Prefrontal Cortex, Amygdala, Eye, Cingulate Cortex, Thyroid

Publications for Bipolar Disorder

Articles related to Bipolar Disorder:

(show top 50) (show all 27765)
# Title Authors PMID Year
COVID-19 patient transcriptomic and genomic profiling reveals comorbidity interactions with psychiatric disorders. 42 61
33723208 2021
Machine learning-based ability to classify psychosis and early stages of disease through parenting and attachment-related variables is associated with social cognition. 42 61
33757595 2021
A retrospective study of pituitary-thyroid interaction in patients with first-episode of bipolar disorder type I in Mania State. 42 61
33578589 2021
Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodes. 54 61
20060128 2010
Analysis of a polymorphic microRNA target site in the purinergic receptor P2RX7 gene. 61 54
20446288 2010
Pro-apoptotic Par-4 and dopamine D2 receptor in temporal cortex in schizophrenia, bipolar disorder and major depression. 54 61
20067857 2010
Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. 54 61
20072116 2010
Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression. 54 61
20080186 2010
Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior. 54 61
19800079 2010
DISC1 duplication in two brothers with autism and mild mental retardation. 54 61
20002455 2010
Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population. 54 61
20396435 2010
Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients. 54 61
19766236 2010
Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population. 54 61
19760522 2010
Influence of neuregulin1 genotype on neural substrate of perceptual matching in children. 61 54
19967439 2010
Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. 61 54
19554614 2010
N-methyl-D-aspartate receptor expression in parvalbumin-containing inhibitory neurons in the prefrontal cortex in bipolar disorder. 61 54
20148871 2010
Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1. 54 61
20148872 2010
Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain. 54 61
20015120 2010
NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD. 61 54
19204064 2010
Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex. 54 61
19683059 2010
Positive association between the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population. 61 54
19330778 2010
Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer in symptomatic manic patients. 54 61
20004480 2010
NRG1 gene in recurrent major depression: no association in a large-scale case-control association study. 54 61
19367584 2010
Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples. 54 61
19350560 2010
Genetics of attention-deficit hyperactivity disorder (ADHD). 61 54
19715710 2009
State-dependent decrease in levels of brain-derived neurotrophic factor in bipolar disorder: a meta-analytic study. 54 61
19786073 2009
Genetic variation in neuregulin1 is associated with differences in prefrontal engagement in children. 61 54
19449332 2009
Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorder. 54 61
19765633 2009
The effect of COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes on hippocampal and lateral ventricular volume in psychosis. 61 54
19573260 2009
Association between the serotonin 2A receptor gene and bipolar affective disorder in an Australian cohort. 54 61
19584773 2009
Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder. 61 54
19191256 2009
Glucocorticoid receptor polymorphisms in major depression. Focus on glucocorticoid sensitivity and neurocognitive functioning. 61 54
19906241 2009
Serum brain-derived neurotrophic factor in bipolar and unipolar depression: a potential adjunctive tool for differential diagnosis. 61 54
19501841 2009
Common and rare variants of DAOA in bipolar disorder. 61 54
19194963 2009
The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis. 54 61
19578924 2009
Phosphorylation status of glucocorticoid receptor, heat shock protein 70, cytochrome c and Bax in lymphocytes of euthymic, depressed and manic bipolar patients. 54 61
19359101 2009
Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS). 54 61
19089808 2009
DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. 61 54
18317464 2009
Decreased brain-derived neurotrophic factor in medicated and drug-free bipolar patients. 54 61
19473667 2009
No association between lithium full responders and the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes in a Sardinian sample. 61 54
19647327 2009
Genetic variation in the G72 (DAOA) gene affects temporal lobe and amygdala structure in subjects affected by bipolar disorder. 54 61
19689504 2009
Cognitive function and serum levels of brain-derived neurotrophic factor in patients with bipolar disorder. 54 61
19689509 2009
The use of triiodothyronine as an augmentation agent in treatment-resistant bipolar II and bipolar disorder NOS. 54 61
19215985 2009
Preliminary evidence on the association between XBP1-116C/G polymorphism and response to prophylactic treatment with valproate in bipolar disorders. 54 61
19564049 2009
Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression. 54 61
19278673 2009
Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant. 61 54
19167700 2009
[An association study of brain-derived neurotrophic factor gene polymorphism in bipolar disorders]. 61 54
19953912 2009
BDNF is not associated with schizophrenia: data from a Japanese population study and meta-analysis. 54 61
19406621 2009
Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia. 54 61
19586533 2009
Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies. 54 61
19411841 2009

Variations for Bipolar Disorder

Copy number variations for Bipolar Disorder from CNVD:

7 (show top 50) (show all 399)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 13918 1 100964950 101093664 Deletion Bipolar disorder
2 13959 1 101777242 101789688 Copy number Bipolar disorder
3 14276 1 106411328 106634702 Copy number Bipolar disorder
4 15012 1 111824223 111936532 Deletion Bipolar disorder
5 15144 1 112987422 113369070 Deletion Bipolar disorder
6 15198 1 113388739 114043773 Deletion Bipolar disorder
7 15265 1 114105331 114260861 Deletion Bipolar disorder
8 15293 1 114379103 114611497 Deletion Bipolar disorder
9 15315 1 114627212 115118807 Deletion Bipolar disorder
10 17285 1 142400000 148000000 Deletion Bipolar disorder
11 17371 1 142600000 147000000 Copy number Bipolar disorder
12 17555 1 14341488 14762438 Deletion Bipolar disorder
13 18108 1 144093481 144503421 Deletion Bipolar disorder
14 21577 1 159722810 159884140 Copy number FCGR2A Bipolar disorder
15 21578 1 159722810 159884140 Copy number FCGR2C Bipolar disorder
16 21579 1 159722810 159884140 Copy number FCGR3A Bipolar disorder
17 21580 1 159722810 159884140 Copy number FCGR3B Bipolar disorder
18 21581 1 159722810 159884140 Copy number HSPA6 Bipolar disorder
19 24355 1 179082079 179207535 Deletion Bipolar disorder
20 27840 1 214001144 214182688 Deletion Bipolar disorder
21 30012 1 239069843 239226340 Deletion Bipolar disorder
22 30852 1 246404335 246667943 Deletion Bipolar disorder
23 30991 1 247034191 247138092 Deletion Bipolar disorder
24 31736 1 30336050 30952188 Deletion Bipolar disorder
25 34240 1 53925291 53984359 Copy number GLIS1 Bipolar disorder
26 35075 1 59854502 60323099 Deletion Bipolar disorder
27 35289 1 62052182 62289893 Deletion Bipolar disorder
28 35722 1 66557267 66646247 Copy number PDE4B Bipolar disorder
29 35951 1 696962 803181 Deletion Bipolar disorder
30 37047 1 84784450 84864145 Copy number CTBS Bipolar disorder
31 37048 1 84784450 84864145 Copy number SPATA1 Bipolar disorder
32 37147 1 85996510 86164671 Deletion Bipolar disorder
33 38265 10 10058972 10215130 Deletion Bipolar disorder
34 39159 10 111195021 111323778 Deletion Bipolar disorder
35 39762 10 119100000 135374737 Deletion Bipolar disorder
36 40469 10 128361479 128559816 Deletion Bipolar disorder
37 42381 10 32899498 33000799 Deletion Bipolar disorder
38 42648 10 37554667 37710375 Deletion Bipolar disorder
39 43112 10 44523027 44679489 Copy number Bipolar disorder
40 43587 10 47013328 47173619 Copy number Bipolar disorder
41 44374 10 56148428 56359760 Deletion Bipolar disorder
42 47196 10 90344868 90556337 Deletion Bipolar disorder
43 47223 10 90559662 90957411 Deletion Bipolar disorder
44 49063 11 102652001 102778728 Deletion Bipolar disorder
45 50159 11 114721884 114868905 Deletion Bipolar disorder
46 51811 11 131159857 131261275 Deletion Bipolar disorder
47 51869 11 132518807 132864395 Deletion Bipolar disorder
48 51963 11 133786141 134449982 Deletion Bipolar disorder
49 53165 11 25250128 26084796 Deletion Bipolar disorder
50 53245 11 26949271 27197653 Deletion Bipolar disorder

Expression for Bipolar Disorder

Search GEO for disease gene expression data for Bipolar Disorder.

Pathways for Bipolar Disorder

GO Terms for Bipolar Disorder

Biological processes related to Bipolar Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron projection development GO:0010976 9.43 RELN DISC1 BDNF
2 response to pain GO:0048265 9.16 RELN COMT
3 dopamine metabolic process GO:0042417 8.96 DRD3 COMT
4 learning GO:0007612 8.8 RELN DRD3 COMT

Sources for Bipolar Disorder

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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