MCID: BZR001
MIFTS: 32

Bizarre Leiomyoma

Categories: Cancer diseases
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Aliases & Classifications for Bizarre Leiomyoma

MalaCards integrated aliases for Bizarre Leiomyoma:

Name: Bizarre Leiomyoma 11 14 71
Pleomorphic Leiomyoma 11
Symplastic Leiomyoma 11
Atypical Leiomyoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:5127
NCIt 49 C4257
SNOMED-CT 68 48897006
UMLS 71 C0334478

Summaries for Bizarre Leiomyoma

Disease Ontology: 11 A leiomyoma that is characterized by large, atypical nuclei in otherwise normal appearing leiomyoma and rare or absent mitotic figures.

MalaCards based summary: Bizarre Leiomyoma, also known as pleomorphic leiomyoma, is related to leiomyoma cutis and myofibroma. An important gene associated with Bizarre Leiomyoma is MED12 (Mediator Complex Subunit 12), and among its related pathways/superpathways are Breast cancer pathway and Transcription_P53 signaling pathway. Affiliated tissues include smooth muscle, uterus and prostate, and related phenotypes are neoplasm and no phenotypic analysis

Related Diseases for Bizarre Leiomyoma

Diseases related to Bizarre Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 357)
# Related Disease Score Top Affiliating Genes
1 leiomyoma cutis 30.7 MED12 FH CALD1
2 myofibroma 30.2 MLANA CALD1
3 uterine corpus sarcoma 30.2 KIT CALD1
4 bladder leiomyoma 30.2 KIT CALD1
5 leiomyoma, uterine 30.2 PGR FH ESR1
6 cutaneous fibrous histiocytoma 30.1 MLANA CALD1
7 uterine sarcoma 30.0 KIT ESR1
8 gastric leiomyoma 30.0 KIT CALD1
9 cellular leiomyoma 30.0 PGR NUTM2A MED12 CALD1
10 leiomyoma 29.9 TP53 PGR MED12 KIT FH ESR1
11 breast leiomyoma 29.9 PGR FH CALD1
12 leiomyomatosis 29.9 PGR MED12 FH ESR1
13 uterus leiomyosarcoma 29.7 PGR KIT FH
14 hemangiopericytoma, malignant 29.5 KIT CALD1
15 intravenous leiomyomatosis 29.5 PGR MED12 ESR1 CALD1
16 endometrial adenocarcinoma 29.4 TP53 PGR ESR1 CDKN2A
17 perivascular epithelioid cell tumor 29.4 MLANA KIT CALD1
18 mesenchymal cell neoplasm 29.3 TP53 MLANA KIT CALD1
19 carcinosarcoma 29.2 TP53 PGR KIT CDKN2A
20 smooth muscle tumor 29.1 PGR MED12 KIT ESR1 CALD1
21 testicular cancer 29.1 TP53 MLANA KIT ESR1
22 endometrial cancer 28.4 TP53 PGR KIT ESR1 CDKN2A
23 myoma 28.4 TP53 PGR MED12 KIT FH ESR1
24 renal cell carcinoma, nonpapillary 28.2 TP53 PSMB9 KIT FH ESR1 CDKN2A
25 leiomyosarcoma 28.2 TP53 PSMB9 PGR MLANA MED12 KIT
26 uterine corpus bizarre leiomyoma 11.4
27 atypical polypoid adenomyoma 10.3 MED12 CALD1
28 pulmonary vein leiomyosarcoma 10.3 PGR CALD1
29 lung leiomyoma 10.3 PGR CALD1
30 bartholin's gland disease 10.2 PGR CALD1
31 adenosquamous breast carcinoma 10.2 TP53 PGR
32 basaloid lung carcinoma 10.2 TP53 PGR
33 cervical mucinous adenocarcinoma 10.2 PGR CDKN2A
34 ovarian serous cystadenofibroma 10.2 TP53 PGR
35 b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) 10.2 TP53 CDKN2A
36 ovarian serous adenofibroma 10.2 TP53 PGR
37 prolapse of urethra 10.2 PGR CALD1
38 myxoid leiomyosarcoma 10.2 NUTM2A CALD1
39 esophagus verrucous carcinoma 10.2 TP53 CDKN2A
40 verrucous carcinoma 10.2 TP53 CDKN2A
41 vaginal benign neoplasm 10.2 CDKN2A CALD1
42 endometrial stromal nodule 10.2 NUTM2A CALD1
43 squamous cell papilloma 10.2 TP53 CDKN2A
44 penile benign neoplasm 10.2 TP53 CDKN2A
45 suppressor of tumorigenicity 3 10.2 TP53 CDKN2A
46 breast myofibroblastoma 10.2 ESR1 CALD1
47 ovarian melanoma 10.2 MLANA CALD1
48 conjunctival squamous cell carcinoma 10.2 TP53 CDKN2A
49 conventional leiomyosarcoma 10.2 MLANA CALD1
50 nipple carcinoma 10.2 PGR ESR1

Graphical network of the top 20 diseases related to Bizarre Leiomyoma:



Diseases related to Bizarre Leiomyoma

Symptoms & Phenotypes for Bizarre Leiomyoma

MGI Mouse Phenotypes related to Bizarre Leiomyoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.63 CDKN2A ESR1 KIT PGR PSMB9 TP53
2 no phenotypic analysis MP:0003012 9.43 CDKN2A ESR1 KIT MLANA PGR TP53
3 muscle MP:0005369 9.17 CALD1 CDKN2A ESR1 KIT PGR PSMB9

Drugs & Therapeutics for Bizarre Leiomyoma

Search Clinical Trials, NIH Clinical Center for Bizarre Leiomyoma

Genetic Tests for Bizarre Leiomyoma

Anatomical Context for Bizarre Leiomyoma

Organs/tissues related to Bizarre Leiomyoma:

MalaCards : Smooth Muscle, Uterus, Prostate, Lymph Node, Breast, Ovary, Colon

Publications for Bizarre Leiomyoma

Articles related to Bizarre Leiomyoma:

(show top 50) (show all 162)
# Title Authors PMID Year
1
Recurrent atypical leiomyoma in bladder trigone, confused with uterine fibroids: A case report. 62
36312486 2022
2
Highly Cellular Leiomyoma Mixed With a Focus of Adenomyosis. 62
35999995 2022
3
Imaging findings of atypical leiomyoma of urinary bladder simulating ureterocele. 62
35769310 2022
4
A rare case of benign vulvovaginal leiomyoma: Case report and literature review. 62
35637979 2022
5
Intraparenchymal breast leiomyoma and atypical leiomyoma. 62
35421983 2022
6
Differentiating cellular leiomyoma from uterine sarcoma and atypical leiomyoma using multi-parametric MRI. 62
36276145 2022
7
Leiomyoma with Bizarre Nuclei: A Current Update. 62
36457718 2022
8
Risk of Recurrence in Uterine Leiomyoma with Bizarre Nuclei: a Systematic Review and Meta-Analysis. 62
34754271 2021
9
Leiomyoma with Bizarre Nuclei (Symplastic Leiomyoma) in the Paratubal Cyst Wall: Report of a Rare Case. 62
33635122 2021
10
Degenerative nuclear atypia in pleomorphic adenoma of salivary glands: Histological and immunohistochemical observations. 62
34153653 2021
11
Coexistence of Conventional Leiomyoma, Fumarate Hydratase-deficient Atypical Leiomyoma, and Perivascular Epithelioid Cell Tumor in a Uterus: A Case Study. 62
32265359 2021
12
HISTOPATHOLOGICAL, PROLIFERATIVE, APOPTOTIC AND HORMONAL CHARACTERISTICS OF VARIOUS TYPES OF LEIOMYOMAS. 62
33964839 2021
13
MRI to Differentiate Atypical Leiomyoma from Uterine Sarcoma. 62
32936067 2020
14
Scrotal leiomyoma a rare benign intra-scrotal mass could lead to unnecessary orchiectomy. 62
32368497 2020
15
The First Described Case of Bizarre Leiomyoma of the Portal Vein. 62
31779764 2019
16
Preoperative Differentiation of Uterine Sarcoma from Leiomyoma: Comparison of Three Models Based on Different Segmentation Volumes Using Radiomics. 62
30850967 2019
17
Preliminary utilization of radiomics in differentiating uterine sarcoma from atypical leiomyoma: Comparison on diagnostic efficacy of MRI features and radiomic features. 62
31084757 2019
18
The Use of Smoothelin and Other Antibodies in the Diagnosis of Uterine and Soft Tissue Smooth Muscle Tumors. 62
29189258 2019
19
Diagnostic value of combination serum assay of lactate dehydrogenase, D-dimer, and C-reactive protein for uterine leiomyosarcoma. 62
30152048 2019
20
One case report of giant atypical leiomyoma of the ovary. 62
30290610 2018
21
A clinicopathologic review and obstetric outcome of uterine smooth muscle tumor of uncertain malignant potential (STUMP) in a single institution. 62
29902779 2018
22
Utility of Clinical Parameters and Multiparametric MRI as Predictive Factors for Differentiating Uterine Sarcoma From Atypical Leiomyoma. 62
29422425 2018
23
MVP immunohistochemistry is a useful adjunct in distinguishing leiomyosarcoma from leiomyoma and leiomyoma with bizarre nuclei. 62
29307622 2018
24
Perianal atypical leiomyoma: A case report: Erratum. 62
29595693 2018
25
Perianal atypical leiomyoma: A case report. 62
29310363 2017
26
Elderly patient with atypical leiomyoma of the bladder presenting as flank pain: A case report. 62
29473387 2017
27
Primary inferior vena cava smooth muscle tumor with diffuse bizarre giant nuclei and low mitotic rate: a nomenclatural conundrum. 62
28623706 2017
28
Differentiation of Uterine Leiomyosarcoma from Atypical Leiomyoma: Diagnostic Accuracy of Qualitative MR Imaging Features and Feasibility of Texture Analysis. 62
27921159 2017
29
MR imaging of atypical fibroids. 62
27826698 2016
30
Atypical Leiomyoma With Features Suggesting of Fumarate Hydratase Mutation. 62
26919578 2016
31
Immunoexpression of p53 in cutaneous and subcutaneous leiomyosarcomas. 62
27649950 2016
32
Two Subtypes of Atypical Leiomyoma: Clinical, Histologic, and Molecular Analysis. 62
27015034 2016
33
Leiomyomatosis peritonealis disseminata: A case report and review of the literature. 62
27284430 2016
34
[Atypical leiomyoma in a patient with cutaneous leiomyomatosis and mutation of the enzyme fumarate hydratase]. 62
27382802 2016
35
STUMP - atypowy mięśniak macicy - mimikra guza złośliwego? 62
27306293 2016
36
Immunohistochemical Profile of Uterine Leiomyoma With Bizarre Nuclei; Comparison With Conventional Leiomyoma, Smooth Muscle Tumors of Uncertain Malignant Potential and Leiomyosarcoma. 62
26793616 2015
37
[Metastasizing Leiomyoma of the Lung Detected on Chest X-ray after Surgery for Breast Cancer;Report of a Case]. 62
26759955 2015
38
Development of Uterine Smooth Muscle Tumour of Uncertain Malignant Potential (STUMP) After Laparoscopic Myomectomy of an Atypical Leiomyoma. 62
27679126 2015
39
Case report: Atypical, 'symplastic' leiomyoma recurring as leiomyosarcoma in the vagina. 62
26793761 2015
40
Bizarre leiomyoma of uterus/smooth muscle tumor of uncertain malignant potential: A diagnostic dilemma. 62
26960523 2015
41
Literature review of outcomes and prevalence and case report of leiomyosarcomas and non-typical uterine smooth muscle leiomyoma tumors treated with uterine artery embolization. 62
26117442 2015
42
Immunohistochemical expression of CD44 standard and E-cadherin in atypical leiomyoma and leiomyosarcoma of the uterus. 62
25140670 2015
43
An immunohistochemical analysis of stathmin 1 expression in uterine smooth muscle tumors: differential expression in leiomyosarcomas and leiomyomas. 62
26045786 2015
44
Diagnostic value of progesterone receptor, p16, p53 and pHH3 expression in uterine atypical leiomyoma. 62
26261614 2015
45
Value of counting positive PHH3 cells in the diagnosis of uterine smooth muscle tumors. 62
26191133 2015
46
Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma. 62
24986214 2014
47
Uterine leiomyomas with bizarre nuclei: a clinicopathologic study of 59 cases. 62
25140893 2014
48
[Analysis of the risk factors for postoperative residue, relapse following myomectomy]. 62
25354860 2014
49
Leiomyosarcoma of the vagina: A rare entity with comprehensive review of the literature. 62
25143892 2014
50
Potential diagnostic biomarkers: differential expression of LMP2/β1i and cyclin B1 in human uterine leiomyosarcoma. 62
25296613 2014

Variations for Bizarre Leiomyoma

Expression for Bizarre Leiomyoma

Search GEO for disease gene expression data for Bizarre Leiomyoma.

Pathways for Bizarre Leiomyoma

GO Terms for Bizarre Leiomyoma

Biological processes related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replicative senescence GO:0090399 9.67 TP53 CDKN2A
2 intracellular steroid hormone receptor signaling pathway GO:0030518 9.62 PGR ESR1
3 positive regulation of phospholipase C activity GO:0010863 9.56 KIT ESR1
4 somatic stem cell division GO:0048103 9.33 KIT CDKN2A
5 negative regulation of miRNA maturation GO:1903799 9.13 TP53 ESR1
6 positive regulation of RNA polymerase II transcription preinitiation complex assembly GO:0045899 8.92 TP53 ESR1

Sources for Bizarre Leiomyoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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