MCID: BZR001
MIFTS: 32

Bizarre Leiomyoma

Categories: Cancer diseases

Aliases & Classifications for Bizarre Leiomyoma

MalaCards integrated aliases for Bizarre Leiomyoma:

Name: Bizarre Leiomyoma 12 15 72
Pleomorphic Leiomyoma 12
Symplastic Leiomyoma 12
Atypical Leiomyoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5127
NCIt 50 C4257
SNOMED-CT 68 48897006
UMLS 72 C0334478

Summaries for Bizarre Leiomyoma

Disease Ontology : 12 A leiomyoma that is characterized by large, atypical nuclei in otherwise normal appearing leiomyoma and rare or absent mitotic figures.

MalaCards based summary : Bizarre Leiomyoma, also known as pleomorphic leiomyoma, is related to leiomyoma and smooth muscle tumor. An important gene associated with Bizarre Leiomyoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gene Expression and Gastric cancer. Affiliated tissues include uterus, smooth muscle and prostate, and related phenotypes are cardiovascular system and mortality/aging

Related Diseases for Bizarre Leiomyoma

Diseases related to Bizarre Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 leiomyoma 30.9 PGR MED12 ACTC1
2 smooth muscle tumor 30.6 PGR ACTC1
3 leiomyomatosis 30.3 PGR MED12
4 myoma 30.1 PGR MED12
5 leiomyosarcoma 29.2 TP53 PGR MED12 ACTC1
6 carcinosarcoma 29.1 TP53 PGR ACTC1
7 endometrial adenocarcinoma 29.0 TP53 PGR CDKN2A
8 uterine corpus bizarre leiomyoma 12.5
9 calcifying aponeurotic fibroma 10.4 PGR ACTC1
10 myxoid leiomyosarcoma 10.4 PGR ACTC1
11 benign metastasizing leiomyoma 10.4 PGR ACTC1
12 leiomyoma cutis 10.4
13 perivascular epithelioid cell tumor 10.4 PGR ACTC1
14 chickenpox 10.4 PGR ACTC1
15 lymphangiomatosis 10.4 PGR PCNA
16 vulvar dystrophy 10.4 PGR CDKN2A
17 bartholin's gland benign neoplasm 10.4 PGR CDKN2A
18 endometrial squamous cell carcinoma 10.4 PGR CDKN2A
19 adenoid basal cell carcinoma 10.4 PGR CDKN2A
20 endometrial mucinous adenocarcinoma 10.4 PGR CDKN2A
21 angiomyolipoma 10.3 PGR ACTC1
22 benign meningioma 10.3 PGR PCNA
23 spindle cell carcinoma 10.3 PGR ACTC1
24 infertility 10.3
25 ischemic fasciitis 10.3 CDKN2A ACTC1
26 meningioma, radiation-induced 10.3 PGR PCNA
27 diffuse peritoneal leiomyomatosis 10.3 PGR MED12
28 peritoneal benign neoplasm 10.3 PGR MED12
29 chondromyxoid fibroma 10.2 CDKN2A ACTC1
30 uterine benign neoplasm 10.2 PGR MED12
31 reproductive organ benign neoplasm 10.2 PGR MED12
32 basal cell carcinoma 10.2
33 adenocarcinoma 10.2
34 cutaneous fibrous histiocytoma 10.2
35 pseudo-meigs syndrome 10.2
36 breast fibroadenoma 10.2 PGR MED12
37 endometrium carcinoma in situ 10.1 TP53 PGR
38 breast malignant phyllodes tumor 10.1 TP53 PGR
39 olfactory groove meningioma 10.1 TP53 PGR
40 synchronous bilateral breast carcinoma 10.1 TP53 PGR
41 uterine body mixed cancer 10.1 TP53 PGR
42 papillary serous adenocarcinoma 10.1 TP53 PGR
43 cervical carcinosarcoma 10.1 TP53 PGR
44 female reproductive endometrioid cancer 10.1 TP53 PGR
45 microglandular adenosis 10.1 TP53 PGR
46 anterior cranial fossa meningioma 10.0 TP53 PGR
47 adenosarcoma 10.0 TP53 PGR
48 uterine corpus cancer 10.0 TP53 PGR
49 malignant giant cell tumor 10.0 TP53 ACTC1
50 spiradenoma 10.0 TP53 ACTC1

Graphical network of the top 20 diseases related to Bizarre Leiomyoma:



Diseases related to Bizarre Leiomyoma

Symptoms & Phenotypes for Bizarre Leiomyoma

MGI Mouse Phenotypes related to Bizarre Leiomyoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.55 ACTC1 CDKN2A MED12 PGR TP53
2 mortality/aging MP:0010768 9.43 ACTC1 CDKN2A MED12 PCNA PGR TP53
3 no phenotypic analysis MP:0003012 8.92 CDKN2A PCNA PGR TP53

Drugs & Therapeutics for Bizarre Leiomyoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Concordance Between Gynaecologic Sonography Amd Pelvic MRI for the Pre-surgical Diagnosis of Uterine Mesenchimal Malignant Tumors Unknown status NCT02940041

Search NIH Clinical Center for Bizarre Leiomyoma

Genetic Tests for Bizarre Leiomyoma

Anatomical Context for Bizarre Leiomyoma

MalaCards organs/tissues related to Bizarre Leiomyoma:

41
Uterus, Smooth Muscle, Prostate, Colon

Publications for Bizarre Leiomyoma

Articles related to Bizarre Leiomyoma:

(show top 50) (show all 80)
# Title Authors PMID Year
1
MVP immunohistochemistry is a useful adjunct in distinguishing leiomyosarcoma from leiomyoma and leiomyoma with bizarre nuclei. 38
29307622 2018
2
Primary inferior vena cava smooth muscle tumor with diffuse bizarre giant nuclei and low mitotic rate: a nomenclatural conundrum. 38
28623706 2017
3
Leiomyomatosis peritonealis disseminata: A case report and review of the literature. 38
27284430 2016
4
Case report: Atypical, 'symplastic' leiomyoma recurring as leiomyosarcoma in the vagina. 38
26793761 2015
5
Bizarre leiomyoma of uterus/smooth muscle tumor of uncertain malignant potential: A diagnostic dilemma. 38
26960523 2015
6
Literature review of outcomes and prevalence and case report of leiomyosarcomas and non-typical uterine smooth muscle leiomyoma tumors treated with uterine artery embolization. 38
26117442 2015
7
An immunohistochemical analysis of stathmin 1 expression in uterine smooth muscle tumors: differential expression in leiomyosarcomas and leiomyomas. 38
26045786 2015
8
[Analysis of the risk factors for postoperative residue, relapse following myomectomy]. 38
25354860 2014
9
Potential diagnostic biomarkers: differential expression of LMP2/β1i and cyclin B1 in human uterine leiomyosarcoma. 38
25296613 2014
10
Bizarre leiomyoma of the scrotum: A case report and review of the literature. 38
24765204 2014
11
Endometrioid carcinoma infiltrating atypical leiomyoma: a mimicker of malignant mixed Mullerian tumor. 38
24943777 2014
12
Pelvic periprostatic symplastic leiomyoma: an unusual case necessitating a radical surgery. 38
23771381 2013
13
Symplastic leiomyoma in the suprarenal inferior vena cava. 38
23599711 2012
14
FDG-PET/CT findings of atypical (bizarre/symplastic) uterine leiomyoma in a patient with abdominal leiomyosarcoma. 38
27326292 2012
15
Removal of a large bizarre uterine leiomyoma by operative hysteroscopy. Case report and review of the literature. 38
22675972 2012
16
Symplastic leiomyoma of uterus--a clinico-pathological dilemma. 38
22674600 2011
17
Uterine smooth muscle tumors of uncertain malignant potential and atypical leiomyoma: a morphological study of these grey zones with clinical correlation. 38
22234095 2011
18
Successful pregnancy outcome after laparoscopic-assisted excision of a bizarre leiomyoma: a case report. 38
21812974 2011
19
Atypical (symplastic) leiomyoma of the uterus--a case report. 38
22041803 2011
20
Smooth muscle neoplasms of the urinary bladder: a clinicopathologic study of 51 cases. 38
20154594 2010
21
Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. 38
20179432 2010
22
Cutaneous leiomyomas and leiomyosarcomas: an immunohistochemical study with p53. 38
20495746 2010
23
Suprarenal symplastic leiomyoma of the inferior vena cava. 38
19733033 2009
24
Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areas. 38
19633649 2009
25
Atypical leiomyoma: An unusual variant of cutaneous pilar leiomyoma. 38
19379650 2009
26
A rare symplastic or bizarre leiomyoma of the scrotum: a case report and review of the literature. 38
19068127 2008
27
Bizarre leiomyoma of the posterior vaginal fornix. 38
18501906 2008
28
Immunohistochemical analysis of p16, p53, and Ki-67 expression in uterine smooth muscle tumors. 38
18580309 2008
29
Symplastic leiomyoma of uterus: a rare histological variant. 38
18541089 2008
30
A case of cutaneous symplastic leiomyoma - a rare variant of cutaneous pilar leiomyoma. 38
18251750 2008
31
Uterine leiomyomas with inclusion bodies: an immunohistochemical and ultrastructural analysis of 12 cases. 38
17306931 2007
32
Symplastic hemangioma: report of two cases. 38
17083693 2006
33
Myxoid symplastic leiomyoma of the uterus. 38
16753760 2006
34
Bizarre leiomyoma of the soft tissue. 38
16194835 2005
35
Bizarre leiomyoma of scrotum. 38
16146275 2005
36
Cutaneous leiomyoma with cytologic atypia, akin to uterine symplastic leiomyoma. 38
15355371 2004
37
Pathologic quiz case: a 40-year-old woman with a large pelvic mass, ascites, massive right hydrothorax, and elevated CA 125. Uterine symplastic leiomyoma associated with pseudo-Meigs syndrome and elevated CA 125. 38
15270600 2004
38
[Atypical or bizarre leiomyoma of the scrotum. Report of one case and bibliographic review]. 38
15270287 2004
39
Pathologic quiz case: a 69-year-old asymptomatic man with a scrotal mass. Atypical (symplastic or bizarre) leiomyoma of the scrotum. 38
14736263 2004
40
[The differential diagnosis between uterine leiomyosarcoma and the special subtypes of leiomyoma]. 38
14521746 2003
41
Bizarre leiomyoma of the scrotum. 38
12808340 2003
42
Atypical (bizarre) leiomyoma of the nasal cavity with prominent myxoid change. 38
12401830 2002
43
[A clinicopathological study of bizarre leiomyoma]. 38
12485480 2002
44
Mesenchymal tumors of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumors--a clinicopathologic and immunohistochemical study of eighty-eight cases. 38
11598163 2001
45
Atypical pilar leiomyoma: cutaneous counterpart of uterine symplastic leiomyoma? 38
11481520 2001
46
Bizarre leiomyoma of the vagina: report of a case. 38
10782419 2000
47
Bizarre leiomyoma of the epididymis. A case report. 38
11517827 2000
48
Association of multiple familial cutaneous leiomyoma with a uterine symplastic leiomyoma. 38
10671972 2000
49
Expression of cyclins and cyclin-dependent kinases in smooth muscle tumors of the uterus. 38
10371341 1999
50
Expression of steroid receptors, Ki-67, and p53 in uterine leiomyosarcomas. 38
9891238 1999

Variations for Bizarre Leiomyoma

Expression for Bizarre Leiomyoma

Search GEO for disease gene expression data for Bizarre Leiomyoma.

Pathways for Bizarre Leiomyoma

Pathways related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 TP53 PGR PCNA MED12 CDKN2A
2
Show member pathways
12.4 TP53 PGR CDKN2A
3
Show member pathways
12.22 TP53 PCNA CDKN2A
4
Show member pathways
12.17 TP53 PCNA CDKN2A
5 12.1 TP53 PCNA CDKN2A
6 11.84 TP53 PCNA CDKN2A
7 11.79 TP53 PCNA CDKN2A
8
Show member pathways
11.45 TP53 CDKN2A
9 11.44 TP53 CDKN2A
10 11.43 TP53 CDKN2A
11 11.27 TP53 CDKN2A
12 11.23 TP53 CDKN2A
13 11.14 TP53 PCNA
14 10.94 TP53 CDKN2A
15 10.91 TP53 PCNA
16 10.83 TP53 PCNA
17 10.82 TP53 PCNA CDKN2A
18
Show member pathways
10.5 TP53 CDKN2A
19 10.3 TP53 CDKN2A

GO Terms for Bizarre Leiomyoma

Biological processes related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.5 TP53 CDKN2A ACTC1
2 Ras protein signal transduction GO:0007265 9.37 TP53 CDKN2A
3 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.26 TP53 PCNA
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.26 TP53 PGR MED12 CDKN2A
5 cellular response to UV GO:0034644 9.16 TP53 PCNA
6 replicative senescence GO:0090399 8.62 TP53 CDKN2A

Molecular functions related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.54 TP53 PCNA MED12
2 enzyme binding GO:0019899 9.43 TP53 PGR PCNA
3 transcription factor binding GO:0008134 9.33 TP53 MED12 CDKN2A
4 receptor tyrosine kinase binding GO:0030971 9.32 TP53 PCNA
5 disordered domain specific binding GO:0097718 8.96 TP53 CDKN2A
6 histone acetyltransferase binding GO:0035035 8.62 TP53 PCNA

Sources for Bizarre Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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