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MCID: BZR001
MIFTS: 30

Bizarre Leiomyoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Bizarre Leiomyoma

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MalaCards integrated aliases for Bizarre Leiomyoma:

Name: Bizarre Leiomyoma 12 15 71
Pleomorphic Leiomyoma 12
Symplastic Leiomyoma 12
Atypical Leiomyoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
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External Ids:

Disease Ontology 12 DOID:5127
NCIt 49 C4257
SNOMED-CT 67 48897006
UMLS 71 C0334478
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Summaries for Bizarre Leiomyoma

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Disease Ontology : 12 A leiomyoma that is characterized by large, atypical nuclei in otherwise normal appearing leiomyoma and rare or absent mitotic figures.

MalaCards based summary : Bizarre Leiomyoma, also known as pleomorphic leiomyoma, is related to cutaneous fibrous histiocytoma and leiomyoma cutis. An important gene associated with Bizarre Leiomyoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Ovarian tumor domain proteases. Affiliated tissues include breast, uterus and smooth muscle, and related phenotype is Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435).

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Related Diseases for Bizarre Leiomyoma

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Diseases related to Bizarre Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 cutaneous fibrous histiocytoma 30.5 CLEC2A ACTC1
2 leiomyoma cutis 30.5 MED12 FH CLEC2A
3 gastric leiomyoma 30.2 FH CALD1
4 cellular leiomyoma 29.9 PCNA MED12 CALD1
5 intravenous leiomyomatosis 29.8 PGR ESR1 CALD1
6 leiomyoma 29.8 PGR PCNA MED12 FH ESR1 ACTC1
7 mesenchymal cell neoplasm 29.8 TP53 CALD1
8 carcinosarcoma 29.6 TP53 PGR ACTC1
9 endometrial adenocarcinoma 29.3 TP53 PGR ESR1
10 leiomyomatosis 29.3 PGR MED12 FH ESR1
11 leiomyoma, uterine 29.1 PGR MED12 FH ESR1
12 myoma 28.6 PGR MED12 FH ESR1 CALD1
13 smooth muscle tumor 28.6 PGR MED12 FH ESR1 CALD1 ACTC1
14 leiomyosarcoma 28.0 TP53 PSMB9 PGR MED12 FH ESR1
15 uterine corpus bizarre leiomyoma 12.5
16 calcifying aponeurotic fibroma 10.4 PGR ACTC1
17 glycogen-rich clear cell breast carcinoma 10.4 PGR ACTC1
18 benign metastasizing leiomyoma 10.4 PGR ACTC1
19 lymphangiomatosis 10.4 PGR PCNA
20 lymphangioma 10.4 PCNA ACTC1
21 breast myoepithelial carcinoma 10.4 PGR ACTC1
22 myxoid leiomyosarcoma 10.4 PGR ACTC1
23 eccrine papillary adenocarcinoma 10.3 PGR CLEC2A
24 benign breast phyllodes tumor 10.3 PGR MED12
25 pulmonary vein leiomyosarcoma 10.3 PGR CALD1
26 vagina leiomyoma 10.3 PGR CALD1
27 cystic nephroma 10.3 PGR ACTC1
28 infertility 10.3
29 apocrine sweat gland neoplasm 10.3 PGR CLEC2A
30 glomangiomyoma 10.3 CALD1 ACTC1
31 vaginal benign neoplasm 10.3 PGR CALD1
32 cervical polyp 10.3 PGR CALD1
33 glassy cell carcinoma of the cervix 10.3 PGR ESR1
34 bartholin's gland adenoid cystic carcinoma 10.3 PGR ESR1
35 chronic tympanitis 10.3 PGR ESR1
36 granulomatous endometritis 10.3 PGR ESR1
37 endometritis 10.3 PGR ESR1
38 breast juvenile papillomatosis 10.3 PGR ESR1
39 glomangioma 10.3 CALD1 ACTC1
40 mucinous cystadenocarcinoma 10.3 PCNA ACTC1
41 vulvar syringoma 10.3 PGR ESR1
42 trigonitis 10.3 PGR ESR1
43 breast scirrhous carcinoma 10.3 PGR ESR1
44 oncocytic breast carcinoma 10.3 PGR ESR1
45 uterus leiomyosarcoma 10.3 PGR CALD1
46 adult type testicular granulosa cell tumor 10.3 PGR ESR1
47 breast papillary carcinoma 10.3 PGR ESR1
48 liver leiomyoma 10.2 PGR ESR1
49 breast metaplastic carcinoma 10.2 PGR ESR1
50 mammographic density 10.2 PGR ESR1

Graphical network of the top 20 diseases related to Bizarre Leiomyoma:



Diseases related to Bizarre Leiomyoma
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Symptoms & Phenotypes for Bizarre Leiomyoma

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GenomeRNAi Phenotypes related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.8 ESR1 FH PCNA
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Drugs & Therapeutics for Bizarre Leiomyoma

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Concordance Between Gynaecologic Sonography Amd Pelvic MRI for the Pre-surgical Diagnosis of Uterine Mesenchimal Malignant Tumors Unknown status NCT02940041

Search NIH Clinical Center for Bizarre Leiomyoma

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Genetic Tests for Bizarre Leiomyoma

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Anatomical Context for Bizarre Leiomyoma

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MalaCards organs/tissues related to Bizarre Leiomyoma:

40
Breast, Uterus, Smooth Muscle, Ovary, Prostate, Colon, Liver
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Publications for Bizarre Leiomyoma

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Articles related to Bizarre Leiomyoma:

(show top 50) (show all 81)
# Title Authors PMID Year
1
The First Described Case of Bizarre Leiomyoma of the Portal Vein. 61
31779764 2019
2
MVP immunohistochemistry is a useful adjunct in distinguishing leiomyosarcoma from leiomyoma and leiomyoma with bizarre nuclei. 61
29307622 2018
3
Primary inferior vena cava smooth muscle tumor with diffuse bizarre giant nuclei and low mitotic rate: a nomenclatural conundrum. 61
28623706 2017
4
Leiomyomatosis peritonealis disseminata: A case report and review of the literature. 61
27284430 2016
5
Case report: Atypical, 'symplastic' leiomyoma recurring as leiomyosarcoma in the vagina. 61
26793761 2015
6
Bizarre leiomyoma of uterus/smooth muscle tumor of uncertain malignant potential: A diagnostic dilemma. 61
26960523 2015
7
Literature review of outcomes and prevalence and case report of leiomyosarcomas and non-typical uterine smooth muscle leiomyoma tumors treated with uterine artery embolization. 61
26117442 2015
8
An immunohistochemical analysis of stathmin 1 expression in uterine smooth muscle tumors: differential expression in leiomyosarcomas and leiomyomas. 61
26045786 2015
9
[Analysis of the risk factors for postoperative residue, relapse following myomectomy]. 61
25354860 2014
10
Potential diagnostic biomarkers: differential expression of LMP2/β1i and cyclin B1 in human uterine leiomyosarcoma. 61
25296613 2014
11
Bizarre leiomyoma of the scrotum: A case report and review of the literature. 61
24765204 2014
12
Endometrioid carcinoma infiltrating atypical leiomyoma: a mimicker of malignant mixed Mullerian tumor. 61
24943777 2014
13
Pelvic periprostatic symplastic leiomyoma: an unusual case necessitating a radical surgery. 61
23771381 2013
14
Symplastic leiomyoma in the suprarenal inferior vena cava. 61
23599711 2012
15
FDG-PET/CT findings of atypical (bizarre/symplastic) uterine leiomyoma in a patient with abdominal leiomyosarcoma. 61
27326292 2012
16
Removal of a large bizarre uterine leiomyoma by operative hysteroscopy. Case report and review of the literature. 61
22675972 2012
17
Symplastic leiomyoma of uterus--a clinico-pathological dilemma. 61
22674600 2011
18
Uterine smooth muscle tumors of uncertain malignant potential and atypical leiomyoma: a morphological study of these grey zones with clinical correlation. 61
22234095 2011
19
Successful pregnancy outcome after laparoscopic-assisted excision of a bizarre leiomyoma: a case report. 61
21812974 2011
20
Atypical (symplastic) leiomyoma of the uterus--a case report. 61
22041803 2011
21
Smooth muscle neoplasms of the urinary bladder: a clinicopathologic study of 51 cases. 61
20154594 2010
22
Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. 61
20179432 2010
23
Cutaneous leiomyomas and leiomyosarcomas: an immunohistochemical study with p53. 61
20495746 2010
24
Suprarenal symplastic leiomyoma of the inferior vena cava. 61
19733033 2009
25
Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areas. 61
19633649 2009
26
Atypical leiomyoma: An unusual variant of cutaneous pilar leiomyoma. 61
19379650 2009
27
A rare symplastic or bizarre leiomyoma of the scrotum: a case report and review of the literature. 61
19068127 2008
28
Bizarre leiomyoma of the posterior vaginal fornix. 61
18501906 2008
29
Immunohistochemical analysis of p16, p53, and Ki-67 expression in uterine smooth muscle tumors. 61
18580309 2008
30
Symplastic leiomyoma of uterus: a rare histological variant. 61
18541089 2008
31
A case of cutaneous symplastic leiomyoma - a rare variant of cutaneous pilar leiomyoma. 61
18251750 2008
32
Uterine leiomyomas with inclusion bodies: an immunohistochemical and ultrastructural analysis of 12 cases. 61
17306931 2007
33
Symplastic hemangioma: report of two cases. 61
17083693 2006
34
Myxoid symplastic leiomyoma of the uterus. 61
16753760 2006
35
Bizarre leiomyoma of the soft tissue. 61
16194835 2005
36
Bizarre leiomyoma of scrotum. 61
16146275 2005
37
Cutaneous leiomyoma with cytologic atypia, akin to uterine symplastic leiomyoma. 61
15355371 2004
38
Pathologic quiz case: a 40-year-old woman with a large pelvic mass, ascites, massive right hydrothorax, and elevated CA 125. Uterine symplastic leiomyoma associated with pseudo-Meigs syndrome and elevated CA 125. 61
15270600 2004
39
[Atypical or bizarre leiomyoma of the scrotum. Report of one case and bibliographic review]. 61
15270287 2004
40
Pathologic quiz case: a 69-year-old asymptomatic man with a scrotal mass. Atypical (symplastic or bizarre) leiomyoma of the scrotum. 61
14736263 2004
41
[The differential diagnosis between uterine leiomyosarcoma and the special subtypes of leiomyoma]. 61
14521746 2003
42
Bizarre leiomyoma of the scrotum. 61
12808340 2003
43
Atypical (bizarre) leiomyoma of the nasal cavity with prominent myxoid change. 61
12401830 2002
44
[A clinicopathological study of bizarre leiomyoma]. 61
12485480 2002
45
Mesenchymal tumors of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumors--a clinicopathologic and immunohistochemical study of eighty-eight cases. 61
11598163 2001
46
Atypical pilar leiomyoma: cutaneous counterpart of uterine symplastic leiomyoma? 61
11481520 2001
47
Bizarre leiomyoma of the vagina: report of a case. 61
10782419 2000
48
Bizarre leiomyoma of the epididymis. A case report. 61
11517827 2000
49
Association of multiple familial cutaneous leiomyoma with a uterine symplastic leiomyoma. 61
10671972 2000
50
Expression of cyclins and cyclin-dependent kinases in smooth muscle tumors of the uterus. 61
10371341 1999
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Variations for Bizarre Leiomyoma

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Expression for Bizarre Leiomyoma

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Search GEO for disease gene expression data for Bizarre Leiomyoma.
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Pathways for Bizarre Leiomyoma

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Pathways related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Chks in Checkpoint Regulation 63
Show member pathways
 11.86 TP53 PSMB9 PCNA ESR1
2
Ovarian tumor domain proteases 65
10.94 TP53 ESR1
3
Signaling mediated by p38-alpha and p38-beta 1
10.87 TP53 ESR1
4
Thyroid hormone signaling pathway 36
10.87 TP53 MED12 ESR1
5
GADD45 Pathway 63
10.76 TP53 PCNA
6
BARD1 signaling events 1
10.62 TP53 PCNA
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GO Terms for Bizarre Leiomyoma

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Cellular components related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replication fork GO:0005657 8.62 TP53 PCNA

Biological processes related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.33 PGR MED12 ESR1
2 embryonic organ development GO:0048568 9.26 TP53 MED12
3 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 8.96 TP53 ESR1
4 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 8.62 TP53 ESR1

Molecular functions related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone acetyltransferase binding GO:0035035 9.32 TP53 PCNA
2 steroid binding GO:0005496 9.26 PGR ESR1
3 chromatin binding GO:0003682 9.26 TP53 PCNA MED12 ESR1
4 myosin binding GO:0017022 9.16 CALD1 ACTC1
5 enzyme binding GO:0019899 8.92 TP53 PGR PCNA ESR1
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Sources for Bizarre Leiomyoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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