BKN
MCID: BKV001
MIFTS: 22

Bk-Virus Nephropathy (BKN)

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Bk-Virus Nephropathy

MalaCards integrated aliases for Bk-Virus Nephropathy:

Name: Bk-Virus Nephropathy 20
Bk Virus Nephropathy 20 71
Nephropathy from Bk Virus 20
Polyomavirus Nephropathy 20
Bkn 20

Classifications:



External Ids:

UMLS 71 C1697878

Summaries for Bk-Virus Nephropathy

MalaCards based summary : Bk-Virus Nephropathy, also known as bk virus nephropathy, is related to interstitial nephritis and polyomavirus-associated nephropathy. An important gene associated with Bk-Virus Nephropathy is HLA-E (Major Histocompatibility Complex, Class I, E). The drugs Everolimus and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, pancreas and t cells.

Related Diseases for Bk-Virus Nephropathy

Diseases in the C1q Nephropathy family:

Bk-Virus Nephropathy

Diseases related to Bk-Virus Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 interstitial nephritis 10.4
2 polyomavirus-associated nephropathy 10.4
3 cystitis 10.4
4 end stage renal disease 10.3
5 hemorrhagic cystitis 10.2
6 glomerulonephritis 10.2
7 iga glomerulonephritis 10.2
8 myelodysplastic syndrome 10.2
9 proteinuria, chronic benign 10.2
10 human cytomegalovirus infection 10.2
11 leukemia, chronic lymphocytic 10.0
12 vesicoureteral reflux 1 10.0
13 type 1 diabetes mellitus 10.0
14 hypertensive nephropathy 10.0
15 peripartum cardiomyopathy 10.0
16 disease by infectious agent 10.0
17 epstein-barr virus hepatitis 10.0
18 exanthem 10.0
19 diffuse large b-cell lymphoma 10.0
20 cardiac arrest 10.0
21 lymphoproliferative syndrome 10.0
22 polycystic kidney disease 10.0
23 neuroretinitis 10.0
24 endocarditis 10.0
25 meningoencephalitis 10.0
26 alport syndrome 10.0
27 hydronephrosis 10.0
28 pyelonephritis 10.0
29 pancytopenia 10.0
30 acute kidney tubular necrosis 10.0
31 dilated cardiomyopathy 10.0
32 uveitis 10.0
33 histoplasmosis 10.0
34 pulmonary tuberculosis 10.0
35 adenocarcinoma 10.0
36 retinitis 10.0
37 skin disease 10.0
38 bladder adenocarcinoma 10.0
39 rapidly progressive glomerulonephritis 10.0
40 proliferative glomerulonephritis 10.0
41 mesangial proliferative glomerulonephritis 10.0
42 kidney disease 10.0
43 progressive multifocal leukoencephalopathy 10.0
44 b-cell lymphoma 10.0
45 chronic kidney disease 10.0
46 herpes simplex 10.0
47 chickenpox 10.0
48 molluscum contagiosum 10.0
49 iridocyclitis 10.0
50 meningitis 10.0

Graphical network of the top 20 diseases related to Bk-Virus Nephropathy:



Diseases related to Bk-Virus Nephropathy

Symptoms & Phenotypes for Bk-Virus Nephropathy

Drugs & Therapeutics for Bk-Virus Nephropathy

Drugs for Bk-Virus Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
2
Mycophenolic acid Approved Phase 4 24280-93-1 446541
3 Immunosuppressive Agents Phase 4
4 Immunologic Factors Phase 4
5 Cyclosporins Phase 4
6
Cidofovir Approved Phase 1, Phase 2 113852-37-2 60613
7 Anti-Infective Agents Phase 1, Phase 2
8 Antiviral Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Randomized Two-arms Study Evaluating the BK Viral Clearance in Kidney Transplant Recipients With BK Viremia After Reduction of Immunosuppression Alone vs. Reduction of Immunosuppression and Replacement of Mycophenolate Mofetil by Everolimus Recruiting NCT03216967 Phase 4 everolimus
2 Phase 2 Multicenter, Randomized, Double-blind, Placebo-controlled, Multiple Dosing Interval, 3-period Study of the Safety, Tolerability and Effectiveness of Adoptively Transferred Viralym-M (ALVR105) Multivirus-specific T Cells in Kidney Transplant Recipients With Either High or Low Levels of BK Viremia Recruiting NCT04605484 Phase 2
3 A Randomized, Placebo-Controlled, Dose-Escalation Study to Assess the Safety and Effect of Cidofovir in Renal Transplant Recipients With BK Virus Nephropathy Terminated NCT00138424 Phase 1, Phase 2 Cidofovir;Placebo
4 A Randomized, Double Blind, Placebo Controlled Study to Assess the Safety, Tolerability, and Efficacy of MAU868 for the Prevention of Allograft-threatening BK Virus Infection in Kidney Transplant Recipients Withdrawn NCT03456999 Phase 2
5 Evaluation of a Predictive Immunovirological Test Occurrence of BK Virus Nephropathy in Renal Transplant Completed NCT02049827
6 Evaluation of Renal Pretransplant Serology for BK Virus on the Risk of Post-transplant Viral Reactivation Not yet recruiting NCT04506060
7 BK Viremia and BK Virus Nephropathy Post Kidney Transplant Comparison of New Practices With Traditional Approach: A Combined Retrospective Chart Review and Prospective Observational Study Withdrawn NCT02758288

Search NIH Clinical Center for Bk-Virus Nephropathy

Genetic Tests for Bk-Virus Nephropathy

Anatomical Context for Bk-Virus Nephropathy

MalaCards organs/tissues related to Bk-Virus Nephropathy:

40
Kidney, Pancreas, T Cells, Bone Marrow

Publications for Bk-Virus Nephropathy

Articles related to Bk-Virus Nephropathy:

(show top 50) (show all 267)
# Title Authors PMID Year
1
The role of donor-derived cell-free DNA in the detection of renal allograft injury. 61
33454228 2021
2
BK virus nephropathy in a heart transplant recipient. 61
33527977 2021
3
Validation of a noninvasive prognostic signature for allograft failure following BK virus associated nephropathy. 61
33349997 2020
4
Intragraft gene expression in native kidney BK virus nephropathy versus T cell-mediated rejection: Prospects for molecular diagnosis and risk prediction. 61
32372431 2020
5
Characterizing the frequency of modifiable histological changes observed on surveillance biopsies in pediatric kidney allograft recipients. 61
32556543 2020
6
Use of Leflunomide as an Antiviral Agent with Everolimus for BK Virus Nephropathy Patients After Kidney Transplantation: A Case Series. 61
33235184 2020
7
Investigating Risk Factors for the Development of BK Virus Infection in Kidney Transplant Recipients in Guilan Province during 2007-2015. 61
33084004 2020
8
Effects of intravenous immunoglobulin therapy and Fc gamma receptor polymorphisms on BK virus nephropathy in kidney transplant recipients. 61
32323406 2020
9
The Importance of Kidney Medullary Tissue for the Accurate Diagnosis of BK Virus Allograft Nephropathy. 61
32601093 2020
10
Characterization of aberrant pathways activation and immune microenviroment of BK virus associated nephropathy. 61
32668411 2020
11
Everolimus for BKV nephropathy in kidney transplant recipients: a prospective, controlled study. 61
32533451 2020
12
Outcomes of kidney retransplantation after graft loss as a result of BK virus nephropathy in the era of newer immunosuppressant agents. 61
31765056 2020
13
SARS-CoV-2 receptor networks in diabetic kidney disease, BK-Virus nephropathy and COVID-19 associated acute kidney injury. 61
32511461 2020
14
The Pathophysiology and Impact of Inflammation in Nonscarred Renal Interstitium: The Banff i Lesion. 61
31369519 2020
15
BK virus nephropathy without haemorrhagic cystitis following bone marrow transplantation. 61
31621066 2020
16
BK Virus Nephropathy: Prevalence, Impact and Management Strategies. 61
32821148 2020
17
Impact of Type 1 and Type 2 Diabetes Mellitus on Pancreas Transplant Outcomes. 61
30501589 2019
18
Effect of simultaneous presence of anti-blood group A/B and -HLA antibodies on clinical outcomes in kidney transplantation across positive crossmatch: a nationwide cohort study. 61
31796812 2019
19
Prevalence and Risk Factors of BK Viremia and Clinical Impact of BK Virus Surveillance on Outcomes in Kidney Transplant Recipients: A Single-Center Cross-Sectional Study. 61
30995893 2019
20
Identification of BK Virus Genotypes in Recipients of Renal Transplant in Vietnam. 61
31477425 2019
21
Simultaneous cytomegalovirus glomerulitis and BK virus nephropathy leading to kidney allograft loss. 61
31470994 2019
22
Urinary levels of CCL2 and CXCL10 chemokines as potential biomarkers of ongoing pathological processes in kidney allograft: an association with BK virus nephropathy. 61
31389404 2019
23
HLA-E Polymorphism Determines Susceptibility to BK Virus Nephropathy after Living-Donor Kidney Transplant. 61
31394776 2019
24
Native kidney BK virus nephropathy, a systematic review. 61
30907978 2019
25
Risk factors for death in kidney transplant patients: analysis from a large protocol biopsy registry. 61
29860340 2019
26
Surgical Complications After Pediatric Renal Transplant. 61
28128720 2019
27
Successful Treatment for BK Virus Nephropathy by Leflunomide in a Kidney Transplant Patient: A Case Report. 61
31084921 2019
28
Do Antithymocyte Globulin-Free Acute Rejection Therapies Increase the Risk of Polyoma Nephropathy in Renal Transplant Recipients? 61
31101182 2019
29
Effects of Rituximab on Atherosclerotic Biomarkers in Kidney Transplant Recipients. 61
31101184 2019
30
CD4+ T Cell Immune Response to VP1 and VP3 in BK Virus Infected Recipients of Renal Transplantation. 61
30707648 2019
31
Monoclonal immunoglobulin G deposits on tubular basement membrane in renal allograft: is this significant for chronic allograft injury? 61
30124906 2019
32
Higher Incidence of BK Virus Nephropathy in Pediatric Kidney Allograft Recipients with Alport Syndrome. 61
30978953 2019
33
Bladder Carcinoma Associated with BK Virus in a Renal Allograft Recipient. 61
30983757 2019
34
BK virus nephropathy and multiorgan involvement in a child with heart transplantation
. 61
30526816 2019
35
The therapeutic effect of switching from tacrolimus to low-dose cyclosporine A in renal transplant recipients with BK virus nephropathy. 61
30737303 2019
36
Native kidney BK nephropathy: A case report. 61
30847205 2019
37
A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring. 61
31365568 2019
38
Clinical Significance of Renal Allograft Protocol Biopsies: A Single Tertiary Center Experience in Malaysia. 61
31186948 2019
39
Screening for BK Viremia/Viruria and the Impact of Management of BK Virus Nephropathy in Renal Transplant Recipients. 61
30777529 2019
40
Living-Donor Kidney Transplant With Preformed Donor-Specific Antibodies. 61
30777522 2019
41
BK Virus Nephropathy. 61
30242026 2018
42
BK Virus nephropathy in living donor renal allograft recipients: An observational study from a large transplant center in India. 61
30588968 2018
43
Abnormalities in Protocol Graft Kidney Biopsy 6 Months Posttransplantation in a Tertiary Care Center Hospital of Nepal. 61
30316361 2018
44
BK virus-induced renal allograft nephropathy. 61
29765170 2018
45
Prevalence of BK virus among renal transplant recipients in a tertiary care hospital in Sri Lanka 61
30415516 2018
46
Clinical characteristics and outcomes of late-onset BK virus nephropathy in kidney and kidney-pancreas transplant recipients. 61
29809315 2018
47
Fluoroquinolones and BK Virus Nephropathy: A Myth or a Reality. 61
30158742 2018
48
The utility of surveillance biopsies in pediatric kidney transplantation. 61
29260318 2018
49
Urine biomarkers informative of human kidney allograft rejection and tolerance. 61
29366869 2018
50
Aryl hydrocarbon receptor expression by macrophages and lymphocytes within infiltrates in BK polyomavirus associated nephropathy. 61
29305091 2018

Variations for Bk-Virus Nephropathy

Expression for Bk-Virus Nephropathy

Search GEO for disease gene expression data for Bk-Virus Nephropathy.

Pathways for Bk-Virus Nephropathy

GO Terms for Bk-Virus Nephropathy

Sources for Bk-Virus Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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