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BKN
MCID: BKV001
MIFTS: 24

Bk-Virus Nephropathy (BKN)

Categories: Nephrological diseases, Rare diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Bk-Virus Nephropathy

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MalaCards integrated aliases for Bk-Virus Nephropathy:

Name: Bk-Virus Nephropathy 52
Bk Virus Nephropathy 52 71
Nephropathy from Bk Virus 52
Polyomavirus Nephropathy 52
Bkn 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 71 C1697878
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Summaries for Bk-Virus Nephropathy

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MalaCards based summary : Bk-Virus Nephropathy, also known as bk virus nephropathy, is related to interstitial nephritis and polyomavirus-associated nephropathy. An important gene associated with Bk-Virus Nephropathy is HLA-E (Major Histocompatibility Complex, Class I, E). The drugs Basiliximab and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include kidney, pancreas and testes.

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Related Diseases for Bk-Virus Nephropathy

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Diseases in the C1q Nephropathy family:

Bk-Virus Nephropathy

Diseases related to Bk-Virus Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 interstitial nephritis 10.4
2 polyomavirus-associated nephropathy 10.4
3 cystitis 10.4
4 end stage renal disease 10.4
5 hemorrhagic cystitis 10.3
6 glomerulonephritis 10.3
7 iga glomerulonephritis 10.3
8 myelodysplastic syndrome 10.2
9 neutropenia 10.2
10 kidney disease 10.2
11 cytomegalovirus infection 10.2
12 leukemia, chronic lymphocytic 10.1
13 vesicoureteral reflux 1 10.1
14 hypertensive nephropathy 10.1
15 hepatitis c virus 10.1
16 epstein-barr virus hepatitis 10.1
17 exanthem 10.1
18 diffuse large b-cell lymphoma 10.1
19 cardiac arrest 10.1
20 lymphoproliferative syndrome 10.1
21 polycystic kidney disease 10.1
22 covid-19 10.1
23 neuroretinitis 10.1
24 endocarditis 10.1
25 meningoencephalitis 10.1
26 alport syndrome 10.1
27 hydronephrosis 10.1
28 pyelonephritis 10.1
29 leukemia 10.1
30 pancytopenia 10.1
31 acute kidney tubular necrosis 10.1
32 dilated cardiomyopathy 10.1
33 uveitis 10.1
34 histoplasmosis 10.1
35 severe acute respiratory syndrome 10.1
36 pulmonary tuberculosis 10.1
37 adenocarcinoma 10.1
38 retinitis 10.1
39 skin disease 10.1
40 bladder adenocarcinoma 10.1
41 rapidly progressive glomerulonephritis 10.1
42 proliferative glomerulonephritis 10.1
43 mesangial proliferative glomerulonephritis 10.1
44 progressive multifocal leukoencephalopathy 10.1
45 b-cell lymphoma 10.1
46 chickenpox 10.1
47 molluscum contagiosum 10.1
48 iridocyclitis 10.1
49 meningitis 10.1
50 post-transplant lymphoproliferative disease 10.1

Graphical network of the top 20 diseases related to Bk-Virus Nephropathy:



Diseases related to Bk-Virus Nephropathy
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Symptoms & Phenotypes for Bk-Virus Nephropathy

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Drugs & Therapeutics for Bk-Virus Nephropathy

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Drugs for Bk-Virus Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Basiliximab Approved, Investigational Phase 4 152923-56-3, 179045-86-4
2
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
3
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Everolimus Approved Phase 4 159351-69-6 70789204 6442177
6
Mycophenolic acid Approved Phase 4 24280-93-1 446541
7 Anti-Infective Agents Phase 4
8 Calcineurin Inhibitors Phase 4
9 Antitubercular Agents Phase 4
10 Anti-Bacterial Agents Phase 4
11 Antibiotics, Antitubercular Phase 4
12 Antifungal Agents Phase 4
13 Dermatologic Agents Phase 4
14 Antirheumatic Agents Phase 4
15 Immunosuppressive Agents Phase 4
16 Cyclosporins Phase 4
17 Immunologic Factors Phase 4
18
rituximab Approved Phase 2 174722-31-7 10201696
19
Cidofovir Approved Phase 1, Phase 2 113852-37-2 60613
20 Antibodies, Monoclonal Phase 2
21 Antineoplastic Agents, Immunological Phase 2
22 Antiviral Agents Phase 1, Phase 2
23
Pancrelipase Approved, Investigational 53608-75-6
24 Thymoglobulin
25 pancreatin

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Prospective, Multicenter, Randomized, Evaluating Two Induction Therapies With Simulect® Versus ATG® Fresenius Associated With Tacrolimus and Myfortic® in the Prevention of Treatment Failure, in Sensitized Renal Transplant Completed NCT02377193 Phase 4 Simulect;ATG Fresenius
2 Prospective Randomized Study to Characterize Risk Factors of Polyomavirus-related Transplant Nephropathy and the Impact of Three Immunosuppressive Regimens on Nephropathy Incidence Completed NCT00160966 Phase 4 Ciclosporin and Mycophenolate-mofetil;Tacrolimus and Mycophenolate-mofetil;Tacrolimus and Mycophenolate-mofetil with change from Mycophenolate-mofetil to Everolimus
3 Multicenter Randomized Two-arms Study Evaluating the BK Viral Clearance in Kidney Transplant Recipients With BK Viremia After Reduction of Immunosuppression Alone vs. Reduction of Immunosuppression and Replacement of Mycophenolate Mofetil by Everolimus Recruiting NCT03216967 Phase 4 everolimus
4 Impact of Rituximab Induction and Living Donation on Immunoregulation and Virus Control in Renal Transplantation - a Prospective Pilot Study Completed NCT01136395 Phase 2 Rituximab
5 Conversion From Tacrolimus to Envarsus in Rapid Metabolizers Post Kidney Transplant Protects Against BK Infection Recruiting NCT03762473 Phase 2 Study Group;Control Group
6 A Randomized, Placebo-Controlled, Dose-Escalation Study to Assess the Safety and Effect of Cidofovir in Renal Transplant Recipients With BK Virus Nephropathy Terminated NCT00138424 Phase 1, Phase 2 Cidofovir;Placebo
7 A Randomized, Double Blind, Placebo Controlled Study to Assess the Safety, Tolerability, and Efficacy of MAU868 for the Prevention of Allograft-threatening BK Virus Infection in Kidney Transplant Recipients Withdrawn NCT03456999 Phase 2
8 The Induction Agent Effect on BK Viremia in Renal and Pancreas Transplant Patients Completed NCT00610961
9 Evaluation of a Predictive Immunovirological Test Occurrence of BK Virus Nephropathy in Renal Transplant Completed NCT02049827
10 BK Viremia and BK Virus Nephropathy Post Kidney Transplant Comparison of New Practices With Traditional Approach: A Combined Retrospective Chart Review and Prospective Observational Study Recruiting NCT02758288
11 Validating Injury to Renal Transplant Using Urinary Signatures in Children Active, not recruiting NCT03719339
12 Polyomavirus Aggregates, Haufen, in Voided Urine Samples as Diagnostic Biomarkers of Intra Renal BK-virus Disease: a Prospective Proof-of-concept Study Suspended NCT01094691

Search NIH Clinical Center for Bk-Virus Nephropathy

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Genetic Tests for Bk-Virus Nephropathy

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Anatomical Context for Bk-Virus Nephropathy

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MalaCards organs/tissues related to Bk-Virus Nephropathy:

40
Kidney, Pancreas, Testes, Heart, T Cells, Lung, Bone Marrow
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Publications for Bk-Virus Nephropathy

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Articles related to Bk-Virus Nephropathy:

(show top 50) (show all 259)
# Title Authors PMID Year
1
Characterizing the frequency of modifiable histological changes observed on surveillance biopsies in pediatric kidney allograft recipients. 61
32556543 2020
2
Everolimus for BKV nephropathy in kidney transplant recipients: a prospective, controlled study. 61
32533451 2020
3
Outcomes of kidney retransplantation after graft loss as a result of BK virus nephropathy in the era of newer immunosuppressant agents. 61
31765056 2020
4
Intragraft gene expression in native kidney BK virus nephropathy versus T cell-mediated rejection: Prospects for molecular diagnosis and risk prediction. 61
32372431 2020
5
SARS-CoV-2 receptor networks in diabetic kidney disease, BK-Virus nephropathy and COVID-19 associated acute kidney injury. 61
32511461 2020
6
The Pathophysiology and Impact of Inflammation in Nonscarred Renal Interstitium: The Banff i Lesion. 61
31369519 2020
7
Effects of intravenous immunoglobulin therapy and Fc gamma receptor polymorphisms on BK virus nephropathy in kidney transplant recipients. 61
32323406 2020
8
BK virus nephropathy without haemorrhagic cystitis following bone marrow transplantation. 61
31621066 2020
9
Impact of Type 1 and Type 2 Diabetes Mellitus on Pancreas Transplant Outcomes. 61
30501589 2019
10
Prevalence and Risk Factors of BK Viremia and Clinical Impact of BK Virus Surveillance on Outcomes in Kidney Transplant Recipients: A Single-Center Cross-Sectional Study. 61
30995893 2019
11
Effect of simultaneous presence of anti-blood group A/B and -HLA antibodies on clinical outcomes in kidney transplantation across positive crossmatch: a nationwide cohort study. 61
31796812 2019
12
Identification of BK Virus Genotypes in Recipients of Renal Transplant in Vietnam. 61
31477425 2019
13
Simultaneous cytomegalovirus glomerulitis and BK virus nephropathy leading to kidney allograft loss. 61
31470994 2019
14
Urinary levels of CCL2 and CXCL10 chemokines as potential biomarkers of ongoing pathological processes in kidney allograft: an association with BK virus nephropathy. 61
31389404 2019
15
HLA-E Polymorphism Determines Susceptibility to BK Virus Nephropathy after Living-Donor Kidney Transplant. 61
31394776 2019
16
Native kidney BK virus nephropathy, a systematic review. 61
30907978 2019
17
Risk factors for death in kidney transplant patients: analysis from a large protocol biopsy registry. 61
29860340 2019
18
Successful Treatment for BK Virus Nephropathy by Leflunomide in a Kidney Transplant Patient: A Case Report. 61
31084921 2019
19
Surgical Complications After Pediatric Renal Transplant. 61
28128720 2019
20
Do Antithymocyte Globulin-Free Acute Rejection Therapies Increase the Risk of Polyoma Nephropathy in Renal Transplant Recipients? 61
31101182 2019
21
Effects of Rituximab on Atherosclerotic Biomarkers in Kidney Transplant Recipients. 61
31101184 2019
22
CD4+ T Cell Immune Response to VP1 and VP3 in BK Virus Infected Recipients of Renal Transplantation. 61
30707648 2019
23
Monoclonal immunoglobulin G deposits on tubular basement membrane in renal allograft: is this significant for chronic allograft injury? 61
30124906 2019
24
Higher Incidence of BK Virus Nephropathy in Pediatric Kidney Allograft Recipients with Alport Syndrome. 61
30978953 2019
25
Bladder Carcinoma Associated with BK Virus in a Renal Allograft Recipient. 61
30983757 2019
26
BK virus nephropathy and multiorgan involvement in a child with heart transplantation
. 61
30526816 2019
27
Native kidney BK nephropathy: A case report. 61
30847205 2019
28
The therapeutic effect of switching from tacrolimus to low-dose cyclosporine A in renal transplant recipients with BK virus nephropathy. 61
30737303 2019
29
Screening for BK Viremia/Viruria and the Impact of Management of BK Virus Nephropathy in Renal Transplant Recipients. 61
30777529 2019
30
A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring. 61
31365568 2019
31
Living-Donor Kidney Transplant With Preformed Donor-Specific Antibodies. 61
30777522 2019
32
Clinical Significance of Renal Allograft Protocol Biopsies: A Single Tertiary Center Experience in Malaysia. 61
31186948 2019
33
BK Virus Nephropathy. 61
30242026 2018
34
BK Virus nephropathy in living donor renal allograft recipients: An observational study from a large transplant center in India. 61
30588968 2018
35
Abnormalities in Protocol Graft Kidney Biopsy 6 Months Posttransplantation in a Tertiary Care Center Hospital of Nepal. 61
30316361 2018
36
BK virus-induced renal allograft nephropathy. 61
29765170 2018
37
Prevalence of BK virus among renal transplant recipients in a tertiary care hospital in Sri Lanka 61
30415516 2018
38
Clinical characteristics and outcomes of late-onset BK virus nephropathy in kidney and kidney-pancreas transplant recipients. 61
29809315 2018
39
Fluoroquinolones and BK Virus Nephropathy: A Myth or a Reality. 61
30158742 2018
40
The utility of surveillance biopsies in pediatric kidney transplantation. 61
29260318 2018
41
Urine biomarkers informative of human kidney allograft rejection and tolerance. 61
29366869 2018
42
Aryl hydrocarbon receptor expression by macrophages and lymphocytes within infiltrates in BK polyomavirus associated nephropathy. 61
29305091 2018
43
Identification of potential key protein interaction networks of BK virus nephropathy in patients receiving kidney transplantation. 61
29567951 2018
44
T cell-mediated rejection is a major determinant of inflammation in scarred areas in kidney allografts. 61
29086461 2018
45
Collapsing Glomerulopathy- A Troublemaker for the Renal Allograft: Lessons Learnt. 61
28904428 2017
46
BK Virus Nephropathy: Histological Evolution by Sequential Pathology. 61
28371308 2017
47
BK Virus Nephropathy Revisited. 61
28510315 2017
48
BK viremia surveillance and outcomes in simultaneous pancreas-kidney transplant recipients. 61
28509373 2017
49
Biopsy-Proven BK Virus-Associated Nephropathy: Clinico-Pathologic Correlations. 61
28137206 2017
50
Outcomes of Hepatitis C-Positive Kidney Transplant Recipients Compared With Hepatitis C-Negative Recipients in Today's Era of Immunosuppression: A UNOS Database Analysis With Long-Term Follow-Up. 61
27310008 2017
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Variations for Bk-Virus Nephropathy

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Expression for Bk-Virus Nephropathy

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Search GEO for disease gene expression data for Bk-Virus Nephropathy.
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Pathways for Bk-Virus Nephropathy

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GO Terms for Bk-Virus Nephropathy

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Sources for Bk-Virus Nephropathy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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