MCID: BLC004
MIFTS: 27

Blackwater Fever

Categories: Blood diseases, Infectious diseases, Nephrological diseases

Aliases & Classifications for Blackwater Fever

MalaCards integrated aliases for Blackwater Fever:

Name: Blackwater Fever 12 54 44 15 17 71
Hemoglobinuric, Malaria 12
Malarial Hemoglobinuria 12
Black Water Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14068
ICD9CM 34 084.8
MeSH 44 D001742
NCIt 50 C34426
SNOMED-CT 67 56625005
UMLS 71 C0005681

Summaries for Blackwater Fever

Disease Ontology : 12 A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax.

MalaCards based summary : Blackwater Fever, also known as hemoglobinuric, malaria, is related to acute kidney failure and glucosephosphate dehydrogenase deficiency. An important gene associated with Blackwater Fever is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways is Binding and Uptake of Ligands by Scavenger Receptors. Affiliated tissues include kidney, and related phenotype is hematopoietic system.

Wikipedia : 74 Blackwater fever is a complication of malaria infection in which red blood cells burst in the... more...

Related Diseases for Blackwater Fever

Diseases related to Blackwater Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 acute kidney failure 30.4 MB HP
2 glucosephosphate dehydrogenase deficiency 30.4 HPX HP G6PD
3 hemoglobinuria 30.3 MB HP G6PD
4 methemoglobinemia 30.2 HP G6PD
5 anuria 30.1 MB HP
6 malaria 30.0 MBL2 MB HP G6PD
7 plasmodium falciparum malaria 30.0 MB HP G6PD
8 hemolytic anemia 29.8 HPX HP G6PD
9 hemoglobinopathy 29.8 MB HP G6PD
10 deficiency anemia 29.5 MB HPX HP G6PD
11 trimethoprim allergy 10.2 HP G6PD
12 anemia, congenital dyserythropoietic, type ib 10.2 HP G6PD
13 anemia, nonspherocytic hemolytic, due to g6pd deficiency 10.2 HP G6PD
14 leptospirosis 10.1
15 kidney disease 10.1
16 anemia, autoimmune hemolytic 10.1 HP G6PD
17 testicular yolk sac tumor 10.1 HPX HP
18 gilbert syndrome 10.1 HP G6PD
19 bilirubin metabolic disorder 10.1 HP G6PD
20 trachoma 10.1 MBL2 HP
21 immunoglobulin alpha deficiency 10.1 MBL2 HP
22 rheumatic fever 10.1 MBL2 HP
23 congenital hemolytic anemia 10.1 HP G6PD
24 parasitic protozoa infectious disease 10.0 HP G6PD
25 sickle cell disease 10.0 HP G6PD
26 autoimmune disease 10.0
27 plasmodium falciparum blood infection level 10.0
28 sickle cell anemia 10.0
29 chikungunya 10.0
30 aphasia 10.0
31 hepatorenal syndrome 10.0
32 syphilis 10.0
33 acquired immunodeficiency syndrome 10.0
34 subacute delirium 10.0
35 viral infectious disease 10.0
36 splenomegaly 10.0
37 thalassemia 10.0
38 headache 10.0
39 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
40 metabolic acidosis 9.9
41 thrombocytopenia 9.9
42 pulmonary tuberculosis 9.9 MBL2 HP
43 sodoku disease 9.9 MB HP
44 hemolytic uremic syndrome, atypical 1 9.9 MBL2 HP
45 iron deficiency anemia 9.8 MB G6PD
46 hellp syndrome 9.7 MBL2 HP
47 asthma 9.4 MBL2 MB HP G6PD

Graphical network of the top 20 diseases related to Blackwater Fever:



Diseases related to Blackwater Fever

Symptoms & Phenotypes for Blackwater Fever

MGI Mouse Phenotypes related to Blackwater Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.1 G6PD HP HPX LGALS2 MB MBL2

Drugs & Therapeutics for Blackwater Fever

Search Clinical Trials , NIH Clinical Center for Blackwater Fever

Cochrane evidence based reviews: blackwater fever

Genetic Tests for Blackwater Fever

Anatomical Context for Blackwater Fever

MalaCards organs/tissues related to Blackwater Fever:

40
Kidney

Publications for Blackwater Fever

Articles related to Blackwater Fever:

(show top 50) (show all 198)
# Title Authors PMID Year
1
Glucose-6-phosphate dehydrogenase (G6PD) mutations and haemoglobinuria syndrome in the Vietnamese population. 54 61
19589177 2009
2
The role of glucose-6-phosphate dehydrogenase deficiency in blackwater fever. 54 61
9402415 1997
3
Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. 61 54
7859663 1994
4
Severe Anemia Is Associated with Systemic Inflammation in Young Children Presenting to a Tertiary Hospital in Uganda. 61
32901609 2020
5
Blackwater Fever in Ugandan Children With Severe Anemia is Associated With Poor Postdischarge Outcomes: A Prospective Cohort Study. 61
31300826 2020
6
Exploring association between MBL2 gene polymorphisms and the occurrence of clinical blackwater fever through a case-control study in Congolese children. 61
31941497 2020
7
A Report of Four Cases of Blackwater Fever after Quinine Treatment at Zinder National Hospital, Niger Republic. 61
31534807 2019
8
Severe delayed haemolytic anaemia associated with artemether-lumefantrine treatment of malaria in a Japanese traveller. 61
29127021 2018
9
Blackwater fever in a non-immune patient with Plasmodium falciparum malaria after intravenous artesunate. 61
29394389 2018
10
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment. 61
29338726 2018
11
The Multifactorial Epidemiology of Blackwater Fever. 61
29016337 2017
12
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. 61
28362936 2017
13
[A Case of Blackwater Fever after Treatment for Plasmodium falciparum Malaria]. 61
30212049 2016
14
Historical Review: Problematic Malaria Prophylaxis with Quinine. 61
27185766 2016
15
Dr John Dickinson (1832-1863): The man behind the bird. 61
24906404 2016
16
Blood Trials: Transfusions, Injections, and Experiments in Africa, 1890-1920. 61
26514397 2016
17
An unusual case of blackwater fever. 61
27514973 2016
18
[A rare case of suppurative mesenteric adenitis associated with intussusception in a child: a clinical case]. 61
27279973 2016
19
Severe malaria in children: A descriptive report from Kinshasa, the Democratic Republic of Congo. 61
25957436 2015
20
[Blackwater fever (BWF) of late revelation about a case at the University Hospital of Dakar]. 61
26966497 2015
21
Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. 61
24629047 2014
22
Autoimmunity: from black water fever to regulatory function. 61
24491820 2014
23
Malaria, clinical features and acute crisis in children suffering from sickle cell disease in resource-limited settings: a retrospective description of 90 cases. 61
23816320 2013
24
[Acute renal failure and severe malaria in Congolese children living in Kinshasa, Democratic Republic of Congo]. 61
23402997 2013
25
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. 61
23800033 2013
26
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. 61
23767699 2013
27
Blackwater fever like in murine malaria. 61
23254588 2013
28
Acute renal failure in Congolese children: a tertiary institution experience. 61
22931368 2012
29
Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial. 61
22412067 2012
30
[Haemolytic crisis of blackwater fever following artemether-lumefantrine intake]. 61
20658275 2010
31
Blackwater fever: divine retribution or genetic happenstance? 61
20957905 2010
32
Blackwater fever: the rise and fall of an exotic disease. 61
20013744 2009
33
An imported case of P. falciparum malaria presenting as black water fever with acute renal failure. 61
19945017 2009
34
[Blackwater fever in children during cerebral malaria: 3 case reports in Bamako]. 61
17524629 2007
35
[A mild blackwater fever]. 61
16806779 2006
36
Severe malaria--analysis of prognostic symptoms and signs in 169 patients treated in Gdynia in 1991-2005. 61
17312703 2006
37
Blackwater fever in children, Burundi. 61
16022794 2005
38
Malaria: a 10-year (1994-2003) retrospective study at University Malaya Medical Center (UMMC), Kuala Lumpur, Malaysia. 61
16438181 2005
39
[Blackwater fever during antimalarial treatment in Abidjan (West Africa): report of 41 cases]. 61
15787264 2004
40
Case report: combination artemether-lumefantrine and haemolytic anaemia following a malarial attack. 61
15259474 2003
41
[Methemalbuminnemia after massive hemolysis during blackwater fever]. 61
12805012 2003
42
Epidemiological and clinical aspects of blackwater fever among African children suffering frequent malaria attacks. 61
14584376 2003
43
[Nine cases of falciparum malaria with blackwater fever in Mali]. 61
14628359 2003
44
[Blackwater fever: a case report]. 61
15849955 2003
45
[Blackwater fever]. 61
12355996 2002
46
Blackwater fever treated with artemether. 61
11996443 2001
47
Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review. 61
11283802 2001
48
Severe falciparum malarial complications in Ukhrul, Manipur. 61
11258490 2000
49
[Blackwater fever in adults with sickle cell anemia. Two fatal cases]. 61
11100442 2000
50
[Clinical study on 24 cases of eclampsia with cerebral malaria]. 61
11360644 1999

Variations for Blackwater Fever

Expression for Blackwater Fever

Search GEO for disease gene expression data for Blackwater Fever.

Pathways for Blackwater Fever

Pathways related to Blackwater Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.64 HPX HP

GO Terms for Blackwater Fever

Cellular components related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle lumen GO:0071682 8.62 HPX HP

Biological processes related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hydrogen peroxide GO:0042542 8.96 MB HP
2 acute-phase response GO:0006953 8.62 MBL2 HP

Molecular functions related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 8.8 MBL2 LGALS2 G6PD

Sources for Blackwater Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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