MCID: BLC004
MIFTS: 30

Blackwater Fever

Categories: Blood diseases, Infectious diseases

Aliases & Classifications for Blackwater Fever

MalaCards integrated aliases for Blackwater Fever:

Name: Blackwater Fever 12 54 43 15 17 71
Hemoglobinuric, Malaria 12
Malarial Hemoglobinuria 12
Black Water Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14068
ICD9CM 34 084.8
MeSH 43 D001742
NCIt 49 C34426
SNOMED-CT 67 56625005
UMLS 71 C0005681

Summaries for Blackwater Fever

Disease Ontology : 12 A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax.

MalaCards based summary : Blackwater Fever, also known as hemoglobinuric, malaria, is related to acute kidney failure and hemoglobinuria. An important gene associated with Blackwater Fever is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways is Binding and Uptake of Ligands by Scavenger Receptors. The drugs Acetaminophen and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related phenotypes are Decreased Salmonella proliferation and hematopoietic system

Wikipedia : 74 Blackwater fever is a complication of malaria infection in which red blood cells burst in the... more...

Related Diseases for Blackwater Fever

Diseases related to Blackwater Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 acute kidney failure 30.7 MB HP
2 hemoglobinuria 30.7 MB HP G6PD
3 hemoglobinopathy 30.5 HP G6PD
4 anuria 30.4 MB HP
5 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 30.4 HP G6PD
6 glucosephosphate dehydrogenase deficiency 30.4 HP G6PD CLIC1
7 plasmodium falciparum malaria 30.4 MB HP G6PD
8 hemolytic anemia 30.0 HPX HP G6PD
9 methemoglobinemia 29.9 MB HP G6PD
10 deficiency anemia 29.9 MB HP G6PD
11 malaria 10.7
12 leptospirosis 10.3
13 kidney disease 10.3
14 trimethoprim allergy 10.2 HP G6PD
15 anemia, congenital dyserythropoietic, type ib 10.2 HP G6PD
16 testicular yolk sac tumor 10.2 HPX HP
17 anemia, autoimmune hemolytic 10.2 HP G6PD
18 acute chest syndrome 10.1 HPX G6PD
19 gilbert syndrome 10.1 HP G6PD
20 autoimmune disease 10.1
21 plasmodium falciparum blood infection level 10.1
22 sickle cell anemia 10.1
23 chikungunya 10.1
24 aphasia 10.1
25 thalassemia 10.1
26 hepatorenal syndrome 10.1
27 syphilis 10.1
28 acquired immunodeficiency syndrome 10.1
29 subacute delirium 10.1
30 viral infectious disease 10.1
31 splenomegaly 10.1
32 back pain 10.1
33 bilirubin metabolic disorder 10.1 HP G6PD
34 congenital hemolytic anemia 10.0 HP G6PD
35 carbohydrate metabolic disorder 9.9 HP G6PD
36 iron deficiency anemia 9.9 MB G6PD
37 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
38 metabolic acidosis 9.9
39 anemia, nonspherocytic hemolytic, due to g6pd deficiency 9.8 HP G6PD CLIC1
40 parasitic protozoa infectious disease 9.7 HP G6PD

Graphical network of the top 20 diseases related to Blackwater Fever:



Diseases related to Blackwater Fever

Symptoms & Phenotypes for Blackwater Fever

GenomeRNAi Phenotypes related to Blackwater Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Salmonella proliferation GR00364-A 8.8 CLIC1 MB NTPCR

MGI Mouse Phenotypes related to Blackwater Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.1 CLIC1 G6PD HP HPX LGALS2 MB

Drugs & Therapeutics for Blackwater Fever

Drugs for Blackwater Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved 103-90-2 1983
2
Ibuprofen Approved 15687-27-1 3672
3
Artesunate Approved, Investigational 88495-63-0 6917864 5464098
4 Analgesics, Non-Narcotic
5 Analgesics
6 Antipyretics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paracetamol Effect on Oxidative Stress and Renal Function in Severe Falciparum Malaria With Intravascular Haemolysis: A Randomised Controlled Clinical Trial Completed NCT01641289 Paracetamol;No Paracetamol

Search NIH Clinical Center for Blackwater Fever

Cochrane evidence based reviews: blackwater fever

Genetic Tests for Blackwater Fever

Anatomical Context for Blackwater Fever

MalaCards organs/tissues related to Blackwater Fever:

40
Kidney

Publications for Blackwater Fever

Articles related to Blackwater Fever:

(show top 50) (show all 197)
# Title Authors PMID Year
1
Glucose-6-phosphate dehydrogenase (G6PD) mutations and haemoglobinuria syndrome in the Vietnamese population. 61 54
19589177 2009
2
The role of glucose-6-phosphate dehydrogenase deficiency in blackwater fever. 54 61
9402415 1997
3
Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. 54 61
7859663 1994
4
Blackwater Fever in Ugandan Children With Severe Anemia is Associated With Poor Postdischarge Outcomes: A Prospective Cohort Study. 61
31300826 2020
5
Exploring association between MBL2 gene polymorphisms and the occurrence of clinical blackwater fever through a case-control study in Congolese children. 61
31941497 2020
6
A Report of Four Cases of Blackwater Fever after Quinine Treatment at Zinder National Hospital, Niger Republic. 61
31534807 2019
7
Severe delayed haemolytic anaemia associated with artemether-lumefantrine treatment of malaria in a Japanese traveller. 61
29127021 2018
8
Blackwater fever in a non-immune patient with Plasmodium falciparum malaria after intravenous artesunate. 61
29394389 2018
9
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment. 61
29338726 2018
10
The Multifactorial Epidemiology of Blackwater Fever. 61
29016337 2017
11
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. 61
28362936 2017
12
[A Case of Blackwater Fever after Treatment for Plasmodium falciparum Malaria]. 61
30212049 2016
13
Historical Review: Problematic Malaria Prophylaxis with Quinine. 61
27185766 2016
14
Dr John Dickinson (1832-1863): The man behind the bird. 61
24906404 2016
15
Blood Trials: Transfusions, Injections, and Experiments in Africa, 1890-1920. 61
26514397 2016
16
An unusual case of blackwater fever. 61
27514973 2016
17
[A rare case of suppurative mesenteric adenitis associated with intussusception in a child: a clinical case]. 61
27279973 2016
18
Severe malaria in children: A descriptive report from Kinshasa, the Democratic Republic of Congo. 61
25957436 2015
19
[Blackwater fever (BWF) of late revelation about a case at the University Hospital of Dakar]. 61
26966497 2015
20
Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. 61
24629047 2014
21
Autoimmunity: from black water fever to regulatory function. 61
24491820 2014
22
[Acute renal failure and severe malaria in Congolese children living in Kinshasa, Democratic Republic of Congo]. 61
23402997 2013
23
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. 61
23767699 2013
24
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. 61
23800033 2013
25
Malaria, clinical features and acute crisis in children suffering from sickle cell disease in resource-limited settings: a retrospective description of 90 cases. 61
23816320 2013
26
Blackwater fever like in murine malaria. 61
23254588 2013
27
Acute renal failure in Congolese children: a tertiary institution experience. 61
22931368 2012
28
Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial. 61
22412067 2012
29
[Haemolytic crisis of blackwater fever following artemether-lumefantrine intake]. 61
20658275 2010
30
Blackwater fever: divine retribution or genetic happenstance? 61
20957905 2010
31
Blackwater fever: the rise and fall of an exotic disease. 61
20013744 2009
32
An imported case of P. falciparum malaria presenting as black water fever with acute renal failure. 61
19945017 2009
33
[Blackwater fever in children during cerebral malaria: 3 case reports in Bamako]. 61
17524629 2007
34
[A mild blackwater fever]. 61
16806779 2006
35
Severe malaria--analysis of prognostic symptoms and signs in 169 patients treated in Gdynia in 1991-2005. 61
17312703 2006
36
Blackwater fever in children, Burundi. 61
16022794 2005
37
Malaria: a 10-year (1994-2003) retrospective study at University Malaya Medical Center (UMMC), Kuala Lumpur, Malaysia. 61
16438181 2005
38
[Blackwater fever during antimalarial treatment in Abidjan (West Africa): report of 41 cases]. 61
15787264 2004
39
Case report: combination artemether-lumefantrine and haemolytic anaemia following a malarial attack. 61
15259474 2003
40
[Methemalbuminnemia after massive hemolysis during blackwater fever]. 61
12805012 2003
41
Epidemiological and clinical aspects of blackwater fever among African children suffering frequent malaria attacks. 61
14584376 2003
42
[Nine cases of falciparum malaria with blackwater fever in Mali]. 61
14628359 2003
43
[Blackwater fever: a case report]. 61
15849955 2003
44
[Blackwater fever]. 61
12355996 2002
45
Blackwater fever treated with artemether. 61
11996443 2001
46
Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review. 61
11283802 2001
47
Severe falciparum malarial complications in Ukhrul, Manipur. 61
11258490 2000
48
[Blackwater fever in adults with sickle cell anemia. Two fatal cases]. 61
11100442 2000
49
[Clinical study on 24 cases of eclampsia with cerebral malaria]. 61
11360644 1999
50
Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives. 61
10348227 1999

Variations for Blackwater Fever

Expression for Blackwater Fever

Search GEO for disease gene expression data for Blackwater Fever.

Pathways for Blackwater Fever

Pathways related to Blackwater Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.64 HPX HP

GO Terms for Blackwater Fever

Cellular components related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.55 MB HPX HP G6PD CLIC1
2 blood microparticle GO:0072562 9.13 HPX HP CLIC1
3 endocytic vesicle lumen GO:0071682 8.62 HPX HP

Biological processes related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hydrogen peroxide GO:0042542 8.62 MB HP

Sources for Blackwater Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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