MCID: BLC004
MIFTS: 34

Blackwater Fever

Categories: Blood diseases, Infectious diseases

Aliases & Classifications for Blackwater Fever

MalaCards integrated aliases for Blackwater Fever:

Name: Blackwater Fever 12 55 44 15 73
Hemoglobinuric, Malaria 12
Malarial Hemoglobinuria 12
Black Water Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14068
ICD9CM 35 084.8
MeSH 44 D001742
NCIt 50 C34426
SNOMED-CT 68 56625005
UMLS 73 C0005681

Summaries for Blackwater Fever

Disease Ontology : 12 A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax.

MalaCards based summary : Blackwater Fever, also known as hemoglobinuric, malaria, is related to plasmodium falciparum malaria and malaria. An important gene associated with Blackwater Fever is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways is TP53 Regulates Metabolic Genes. The drugs Ibuprofen and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related phenotypes are Increased shRNA abundance and hematopoietic system

Wikipedia : 76 Blackwater fever is a complication of malaria infection in which red blood cells burst in the... more...

Related Diseases for Blackwater Fever

Diseases related to Blackwater Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 plasmodium falciparum malaria 30.1 G6PD HP
2 malaria 10.6
3 hemoglobinuria 10.2
4 anemia, nonspherocytic hemolytic, due to g6pd deficiency 10.1 G6PD HP
5 glucosephosphate dehydrogenase deficiency 10.1 G6PD HP
6 methemoglobinemia 10.1 G6PD HP
7 testicular yolk sac tumor 10.1 HP HPX
8 atransferrinemia 10.1 HP HPX
9 bilirubin metabolic disorder 10.1 G6PD HP
10 autoimmune disease 10.1
11 anuria 10.1
12 syphilis 10.1
13 congenital hemolytic anemia 10.0 G6PD HP
14 alpha-thalassemia 9.9 G6PD HP
15 cholecystitis 9.9 CDKN2A HP
16 acute kidney tubular necrosis 9.9 CDKN2A LRSAM1
17 bladder disease 9.8 CDKN2A PPIG

Graphical network of the top 20 diseases related to Blackwater Fever:



Diseases related to Blackwater Fever

Symptoms & Phenotypes for Blackwater Fever

GenomeRNAi Phenotypes related to Blackwater Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 G6PD HPX KIF5B

MGI Mouse Phenotypes related to Blackwater Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CDKN2A CLIC1 G6PD HP HPX RPTOR
2 homeostasis/metabolism MP:0005376 9.17 CDKN2A CLIC1 G6PD HP HPX KIF5B

Drugs & Therapeutics for Blackwater Fever

Drugs for Blackwater Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Not Applicable 15687-27-1 3672
2
Acetaminophen Approved Not Applicable 103-90-2 1983
3
Artesunate Approved, Investigational Not Applicable 88495-63-0 5464098 6917864
4 Antiparasitic Agents Not Applicable
5 Peripheral Nervous System Agents Not Applicable
6 Analgesics Not Applicable
7 Analgesics, Non-Narcotic Not Applicable
8 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
9 Antiprotozoal Agents Not Applicable
10 Antimalarials Not Applicable
11 Antirheumatic Agents Not Applicable
12 Antipyretics Not Applicable
13 Cyclooxygenase Inhibitors Not Applicable
14 Anti-Inflammatory Agents Not Applicable
15 Anti-Infective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria Completed NCT01641289 Not Applicable Paracetamol;No Paracetamol

Search NIH Clinical Center for Blackwater Fever

Cochrane evidence based reviews: blackwater fever

Genetic Tests for Blackwater Fever

Anatomical Context for Blackwater Fever

MalaCards organs/tissues related to Blackwater Fever:

41
Kidney

Publications for Blackwater Fever

Articles related to Blackwater Fever:

(show top 50) (show all 148)
# Title Authors Year
1
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment. ( 29338726 )
2018
2
Blackwater fever in a non-immune patient with Plasmodium falciparum malaria after intravenous artesunate. ( 29394389 )
2018
3
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. ( 28362936 )
2017
4
The Multifactorial Epidemiology of Blackwater Fever. ( 29016337 )
2017
5
An unusual case of blackwater fever. ( 27514973 )
2016
6
Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. ( 24629047 )
2014
7
Blackwater fever like in murine malaria. ( 23254588 )
2013
8
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. ( 23800033 )
2013
9
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. ( 23767699 )
2013
10
Blackwater fever: divine retribution or genetic happenstance? ( 20957905 )
2010
11
Blackwater fever: the rise and fall of an exotic disease. ( 20013744 )
2009
12
Blackwater fever in children, Burundi. ( 16022794 )
2005
13
Epidemiological and clinical aspects of blackwater fever among African children suffering frequent malaria attacks. ( 14584376 )
2003
14
[Methemalbuminnemia after massive hemolysis during blackwater fever]. ( 12805012 )
2003
15
Blackwater fever treated with artemether. ( 11996443 )
2001
16
Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review. ( 11283802 )
2001
17
Acute intravascular haemolysis (blackwater fever) after antimalarial treatment. ( 10203176 )
1999
18
Recurrence of blackwater fever: triggering of relapses by different antimalarials. ( 9735933 )
1998
19
Blackwater fever: a fatal case. ( 9434932 )
1997
20
The role of glucose-6-phosphate dehydrogenase deficiency in blackwater fever. ( 9402415 )
1997
21
Blackwater fever after halofantrine. ( 8637361 )
1996
22
Blackwater fever in southern Vietnam: a prospective descriptive study of 50 cases. ( 8953071 )
1996
23
Blackwater fever and acute renal failure in expatriates in Africa. ( 8827999 )
1996
24
An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire. ( 7794063 )
1995
25
Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. ( 7859663 )
1994
26
Blackwater fever caused by Plasmodium vivax infection in the acquired immune deficiency syndrome. ( 3130932 )
1988
27
Quinine and the mystery of blackwater fever. ( 3321835 )
1987
28
Drug-induced haemolysis masquerading as blackwater fever. ( 3690650 )
1987
29
Splenectomy and blackwater fever. ( 7104241 )
1982
30
Blackwater fever in Kenya: problems of etiology. ( 4578485 )
1973
31
Erythrocyte morphology in blackwater fever. ( 5485713 )
1970
32
Autoimmune disease and blackwater fever. ( 4179535 )
1969
33
More blackwater fever. ( 5797772 )
1969
34
The kidney in blackwater fever: light and electron microscopic observations. ( 4171380 )
1968
35
A case of blackwater fever. ( 5661211 )
1968
36
Oliguric renal failure in blackwater fever. ( 4881129 )
1968
37
BLACKWATER FEVER AFTER THE USE OF CHLOROQUINE-PYRIMETHAMINE. ( 14055154 )
1963
38
Blackwater fever in Southern Rhodesia in retrospect. ( 13975090 )
1962
39
The artificial kidney in malaria and blackwater fever. ( 14450615 )
1962
40
Treatment of blackwater fever with prednisone. ( 13386233 )
1956
41
Blackwater fever; its etiology and treatment. ( 13246757 )
1955
42
Blackwater fever in an African child. ( 13261152 )
1955
43
A fatal case of blackwater fever associated with ingestion of nivaquine. ( 13169242 )
1954
44
Blackwater fever treated with cortisone. ( 13032514 )
1953
45
BLACKWATER fever; clinical, pathological, and diagnostic features. ( 13076562 )
1953
46
Proguanil and blackwater fever. ( 13019138 )
1953
47
Blackwater fever and the intravascular haemolyses. ( 13058138 )
1952
48
Dextran in blackwater fever. ( 13012413 )
1952
49
Blackwater fever apparently precipitated by proguanil. ( 14852178 )
1951
50
Blackwater fever in African children. ( 14830853 )
1951

Variations for Blackwater Fever

Expression for Blackwater Fever

Search GEO for disease gene expression data for Blackwater Fever.

Pathways for Blackwater Fever

Pathways related to Blackwater Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.55 G6PD RPTOR

GO Terms for Blackwater Fever

Cellular components related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.13 CLIC1 HP HPX
2 endocytic vesicle lumen GO:0071682 8.62 HP HPX

Molecular functions related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 CDKN2A CLIC1 G6PD HP HPX KIF5B

Sources for Blackwater Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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