MCID: BLC004
MIFTS: 25

Blackwater Fever

Categories: Blood diseases, Infectious diseases, Nephrological diseases
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Aliases & Classifications for Blackwater Fever

MalaCards integrated aliases for Blackwater Fever:

Name: Blackwater Fever 11 53 43 14 16 71 75
Hemoglobinuric, Malaria 11
Malarial Hemoglobinuria 11
Black Water Fever 11

Classifications:



External Ids:

Disease Ontology 11 DOID:14068
ICD9CM 34 084.8
MeSH 43 D001742
NCIt 49 C34426
SNOMED-CT 68 56625005
UMLS 71 C0005681

Summaries for Blackwater Fever

Disease Ontology: 11 A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax.

MalaCards based summary: Blackwater Fever, also known as hemoglobinuric, malaria, is related to malaria and glucosephosphate dehydrogenase deficiency. An important gene associated with Blackwater Fever is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways is Binding and Uptake of Ligands by Scavenger Receptors. Affiliated tissues include kidney.

Wikipedia: 75 Blackwater fever is a complication of malaria infection in which red blood cells burst in the... more...

Related Diseases for Blackwater Fever

Diseases related to Blackwater Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 malaria 31.9 MBL2 MB HP G6PD
2 glucosephosphate dehydrogenase deficiency 30.9 HP G6PD
3 hemoglobinuria 30.7 MB HP G6PD
4 acute kidney failure 30.7 MB HP
5 plasmodium falciparum malaria 30.4 MBL2 MB HP G6PD
6 sickle cell anemia 30.3 HPX HP G6PD
7 anuria 30.3 MB HP
8 hemolytic anemia 29.9 HPX HP G6PD
9 methemoglobinemia 29.9 MB HP G6PD
10 deficiency anemia 29.9 PRPF40B MB HP G6PD
11 hemoglobinopathy 29.8 MB HPX HP G6PD
12 turner syndrome 10.3
13 trimethoprim allergy 10.2 HP G6PD
14 leptospirosis 10.2
15 kidney disease 10.2
16 anemia, nonspherocytic hemolytic, due to g6pd deficiency 10.2 HP G6PD
17 anemia, autoimmune hemolytic 10.1 HP G6PD
18 acute chest syndrome 10.1 HPX HP
19 congenital hemolytic anemia 10.1 HP G6PD
20 trachoma 10.1 MBL2 HP
21 immunoglobulin alpha deficiency 10.1 MBL2 HP
22 beta-thalassemia major 10.1 HPX HP
23 paroxysmal nocturnal hemoglobinuria 10.1 HP G6PD
24 rheumatic fever 10.1 MBL2 HP
25 parasitic protozoa infectious disease 10.1 HP G6PD
26 hereditary spherocytosis 10.1 HP G6PD
27 membranous nephropathy 10.0 MBL2 HP
28 porphyria, acute intermittent 10.0 MB HPX
29 gilbert syndrome 10.0 HP G6PD
30 myoglobinuria 10.0 MB HP
31 autoimmune disease 10.0
32 down syndrome 10.0
33 plasmodium falciparum blood infection level 10.0
34 alpha-thalassemia 10.0
35 chikungunya 10.0
36 aphasia 10.0
37 urinary tract infection 10.0
38 thalassemia 10.0
39 hepatorenal syndrome 10.0
40 gastric antral vascular ectasia 10.0
41 syphilis 10.0
42 acquired immunodeficiency syndrome 10.0
43 subacute delirium 10.0
44 leishmaniasis 10.0
45 visceral leishmaniasis 10.0
46 viral infectious disease 10.0
47 splenomegaly 10.0
48 toxoplasmosis 10.0 MB G6PD
49 pulmonary tuberculosis 10.0 MBL2 HP
50 thrombocytopenic purpura, autoimmune 9.9

Graphical network of the top 20 diseases related to Blackwater Fever:



Diseases related to Blackwater Fever

Symptoms & Phenotypes for Blackwater Fever

Drugs & Therapeutics for Blackwater Fever

Search Clinical Trials, NIH Clinical Center for Blackwater Fever

Cochrane evidence based reviews: blackwater fever

Genetic Tests for Blackwater Fever

Anatomical Context for Blackwater Fever

Organs/tissues related to Blackwater Fever:

MalaCards : Kidney

Publications for Blackwater Fever

Articles related to Blackwater Fever:

(show top 50) (show all 240)
# Title Authors PMID Year
1
Glucose-6-phosphate dehydrogenase (G6PD) mutations and haemoglobinuria syndrome in the Vietnamese population. 53 62
19589177 2009
2
The role of glucose-6-phosphate dehydrogenase deficiency in blackwater fever. 53 62
9402415 1997
3
Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. 53 62
7859663 1994
4
Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance. 62
35773743 2022
5
Resurgence of blackwater fever among children in sub-Saharan Africa: a scoping review protocol. 62
35793920 2022
6
Successful Oral Antimalarial Therapy in A 14-Year-Old Child with Blackwater Fever: A Case in a Rural Area of Asmat Regency of Papua, Indonesia: Successful Oral Antimalarial in Blackwater Fever. 62
35755479 2022
7
Autoimmune Dysfunction Due to Severe Malaria. 62
35774704 2022
8
Mystery of blackwater fever from an Australian perspective. 62
35419958 2022
9
Acute kidney injury, persistent kidney disease, and post-discharge morbidity and mortality in severe malaria in children: A prospective cohort study. 62
35198918 2022
10
Predictors of prolonged hospitalisation and mortality among children admitted with blackwater fever in eastern Uganda. 62
34939462 2022
11
Blackwater Fever in Pregnancy With Severe Falciparum Malaria: A Case of Imported Malaria From Nigeria to the United Kingdom During the COVID-19 Pandemic. 62
34900503 2021
12
Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria: a secondary analysis of a randomized trial. 62
34172046 2021
13
Severe Anemia Is Associated with Systemic Inflammation in Young Children Presenting to a Tertiary Hospital in Uganda. 62
32901609 2020
14
Blackwater Fever in Ugandan Children With Severe Anemia is Associated With Poor Postdischarge Outcomes: A Prospective Cohort Study. 62
31300826 2020
15
Exploring association between MBL2 gene polymorphisms and the occurrence of clinical blackwater fever through a case-control study in Congolese children. 62
31941497 2020
16
A Report of Four Cases of Blackwater Fever after Quinine Treatment at Zinder National Hospital, Niger Republic. 62
31534807 2019
17
Severe delayed haemolytic anaemia associated with artemether-lumefantrine treatment of malaria in a Japanese traveller. 62
29127021 2018
18
Blackwater fever in a non-immune patient with Plasmodium falciparum malaria after intravenous artesunate. 62
29394389 2018
19
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment. 62
29338726 2018
20
The Multifactorial Epidemiology of Blackwater Fever. 62
29016337 2017
21
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. 62
28362936 2017
22
[A Case of Blackwater Fever after Treatment for Plasmodium falciparum Malaria]. 62
30212049 2016
23
Historical Review: Problematic Malaria Prophylaxis with Quinine. 62
27185766 2016
24
Dr John Dickinson (1832-1863): The man behind the bird. 62
24906404 2016
25
Blood Trials: Transfusions, Injections, and Experiments in Africa, 1890-1920. 62
26514397 2016
26
An unusual case of blackwater fever. 62
27514973 2016
27
[A rare case of suppurative mesenteric adenitis associated with intussusception in a child: a clinical case]. 62
27279973 2016
28
Severe malaria in children: A descriptive report from Kinshasa, the Democratic Republic of Congo. 62
25957436 2015
29
The clinical pattern of renal diseases in the nephrology in-patient unit of the Yaounde General Hospital in Cameroon: a five-year audit. 62
26421100 2015
30
[Blackwater fever (BWF) of late revelation about a case at the University Hospital of Dakar]. 62
26966497 2015
31
Black water fever associated with acute renal failure among Congolese children in Kinshasa. 62
25394465 2014
32
Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. 62
24629047 2014
33
Autoimmunity: from black water fever to regulatory function. 62
24491820 2014
34
Malaria, clinical features and acute crisis in children suffering from sickle cell disease in resource-limited settings: a retrospective description of 90 cases. 62
23816320 2013
35
[Acute renal failure and severe malaria in Congolese children living in Kinshasa, Democratic Republic of Congo]. 62
23402997 2013
36
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. 62
23767699 2013
37
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. 62
23800033 2013
38
Blackwater fever like in murine malaria. 62
23254588 2013
39
Acute renal failure in Congolese children: a tertiary institution experience. 62
22931368 2012
40
Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial. 62
22412067 2012
41
[Haemolytic crisis of blackwater fever following artemether-lumefantrine intake]. 62
20658275 2010
42
Blackwater fever: divine retribution or genetic happenstance? 62
20957905 2010
43
Artemisinin derivatives versus quinine for cerebral malaria in African children: a systematic review. 62
20454480 2009
44
An imported case of P. falciparum malaria presenting as black water fever with acute renal failure. 62
19945017 2009
45
Blackwater fever: the rise and fall of an exotic disease. 62
20013744 2009
46
[Blackwater fever in children during cerebral malaria: 3 case reports in Bamako]. 62
17524629 2007
47
[A mild blackwater fever]. 62
16806779 2006
48
Severe malaria--analysis of prognostic symptoms and signs in 169 patients treated in Gdynia in 1991-2005. 62
17312703 2006
49
Blackwater fever in children, Burundi. 62
16022794 2005
50
Malaria: a 10-year (1994-2003) retrospective study at University Malaya Medical Center (UMMC), Kuala Lumpur, Malaysia. 62
16438181 2005

Variations for Blackwater Fever

Expression for Blackwater Fever

Search GEO for disease gene expression data for Blackwater Fever.

Pathways for Blackwater Fever

Pathways related to Blackwater Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.58 HPX HP

GO Terms for Blackwater Fever

Cellular components related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle lumen GO:0071682 8.92 HPX HP

Biological processes related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.92 MBL2 HP

Molecular functions related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 8.92 MBL2 LGALS2 G6PD

Sources for Blackwater Fever

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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