MCID: BLC004
MIFTS: 33

Blackwater Fever

Categories: Blood diseases, Infectious diseases

Aliases & Classifications for Blackwater Fever

MalaCards integrated aliases for Blackwater Fever:

Name: Blackwater Fever 12 56 45 15 17 74
Hemoglobinuric, Malaria 12
Malarial Hemoglobinuria 12
Black Water Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14068
ICD9CM 36 084.8
MeSH 45 D001742
NCIt 51 C34426
SNOMED-CT 69 56625005
UMLS 74 C0005681

Summaries for Blackwater Fever

Disease Ontology : 12 A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax.

MalaCards based summary : Blackwater Fever, also known as hemoglobinuric, malaria, is related to plasmodium falciparum malaria and malaria. An important gene associated with Blackwater Fever is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways is TP53 Regulates Metabolic Genes. The drugs Acetaminophen and Artesunate have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related phenotypes are Increased shRNA abundance and homeostasis/metabolism

Wikipedia : 77 Blackwater fever is a complication of malaria infection in which red blood cells burst in the... more...

Related Diseases for Blackwater Fever

Diseases related to Blackwater Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 plasmodium falciparum malaria 30.2 G6PD HP
2 malaria 10.6
3 anemia, nonspherocytic hemolytic, due to g6pd deficiency 10.2 G6PD HP
4 glucosephosphate dehydrogenase deficiency 10.2 G6PD HP
5 hemoglobinuria 10.2
6 methemoglobinemia 10.2 G6PD HP
7 testicular yolk sac tumor 10.2 HP HPX
8 atransferrinemia 10.2 HP HPX
9 bilirubin metabolic disorder 10.2 G6PD HP
10 congenital hemolytic anemia 10.1 G6PD HP
11 autoimmune disease 10.1
12 anuria 10.1
13 syphilis 10.1
14 cholecystitis 10.0 CDKN2A HP
15 acute kidney tubular necrosis 10.0 CDKN2A LRSAM1
16 alpha-thalassemia 9.9 G6PD HP
17 bladder disease 9.8 CDKN2A PPIG

Graphical network of the top 20 diseases related to Blackwater Fever:



Diseases related to Blackwater Fever

Symptoms & Phenotypes for Blackwater Fever

GenomeRNAi Phenotypes related to Blackwater Fever according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 G6PD HPX KIF5B

MGI Mouse Phenotypes related to Blackwater Fever:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 CDKN2A CLIC1 G6PD HP HPX KIF5B

Drugs & Therapeutics for Blackwater Fever

Drugs for Blackwater Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Not Applicable 103-90-2 1983
2
Artesunate Approved, Investigational Not Applicable 88495-63-0 5464098 6917864
3
Ibuprofen Approved Not Applicable 15687-27-1 3672
4 Peripheral Nervous System Agents Not Applicable
5 Anti-Inflammatory Agents Not Applicable
6 Antiviral Agents Not Applicable
7 Anthelmintics Not Applicable
8 Cyclooxygenase Inhibitors Not Applicable
9 Anti-Infective Agents Not Applicable
10 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
11 Antimalarials Not Applicable
12 Antipyretics Not Applicable
13 Antiparasitic Agents Not Applicable
14 Analgesics Not Applicable
15 Antiprotozoal Agents Not Applicable
16 Antirheumatic Agents Not Applicable
17 Analgesics, Non-Narcotic Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria Completed NCT01641289 Not Applicable Paracetamol;No Paracetamol

Search NIH Clinical Center for Blackwater Fever

Cochrane evidence based reviews: blackwater fever

Genetic Tests for Blackwater Fever

Anatomical Context for Blackwater Fever

MalaCards organs/tissues related to Blackwater Fever:

42
Kidney

Publications for Blackwater Fever

Articles related to Blackwater Fever:

(show top 50) (show all 148)
# Title Authors Year
1
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment. ( 29338726 )
2018
2
Blackwater fever in a non-immune patient with Plasmodium falciparum malaria after intravenous artesunate. ( 29394389 )
2018
3
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. ( 28362936 )
2017
4
The Multifactorial Epidemiology of Blackwater Fever. ( 29016337 )
2017
5
An unusual case of blackwater fever. ( 27514973 )
2016
6
Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. ( 24629047 )
2014
7
Blackwater fever like in murine malaria. ( 23254588 )
2013
8
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. ( 23800033 )
2013
9
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. ( 23767699 )
2013
10
Blackwater fever: divine retribution or genetic happenstance? ( 20957905 )
2010
11
Blackwater fever: the rise and fall of an exotic disease. ( 20013744 )
2009
12
Blackwater fever in children, Burundi. ( 16022794 )
2005
13
Epidemiological and clinical aspects of blackwater fever among African children suffering frequent malaria attacks. ( 14584376 )
2003
14
[Methemalbuminnemia after massive hemolysis during blackwater fever]. ( 12805012 )
2003
15
Blackwater fever treated with artemether. ( 11996443 )
2001
16
Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review. ( 11283802 )
2001
17
Acute intravascular haemolysis (blackwater fever) after antimalarial treatment. ( 10203176 )
1999
18
Recurrence of blackwater fever: triggering of relapses by different antimalarials. ( 9735933 )
1998
19
Blackwater fever: a fatal case. ( 9434932 )
1997
20
The role of glucose-6-phosphate dehydrogenase deficiency in blackwater fever. ( 9402415 )
1997
21
Blackwater fever after halofantrine. ( 8637361 )
1996
22
Blackwater fever in southern Vietnam: a prospective descriptive study of 50 cases. ( 8953071 )
1996
23
Blackwater fever and acute renal failure in expatriates in Africa. ( 8827999 )
1996
24
An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire. ( 7794063 )
1995
25
Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. ( 7859663 )
1994
26
Blackwater fever caused by Plasmodium vivax infection in the acquired immune deficiency syndrome. ( 3130932 )
1988
27
Quinine and the mystery of blackwater fever. ( 3321835 )
1987
28
Drug-induced haemolysis masquerading as blackwater fever. ( 3690650 )
1987
29
Splenectomy and blackwater fever. ( 7104241 )
1982
30
Blackwater fever in Kenya: problems of etiology. ( 4578485 )
1973
31
Erythrocyte morphology in blackwater fever. ( 5485713 )
1970
32
Autoimmune disease and blackwater fever. ( 4179535 )
1969
33
More blackwater fever. ( 5797772 )
1969
34
The kidney in blackwater fever: light and electron microscopic observations. ( 4171380 )
1968
35
A case of blackwater fever. ( 5661211 )
1968
36
Oliguric renal failure in blackwater fever. ( 4881129 )
1968
37
BLACKWATER FEVER AFTER THE USE OF CHLOROQUINE-PYRIMETHAMINE. ( 14055154 )
1963
38
Blackwater fever in Southern Rhodesia in retrospect. ( 13975090 )
1962
39
The artificial kidney in malaria and blackwater fever. ( 14450615 )
1962
40
Treatment of blackwater fever with prednisone. ( 13386233 )
1956
41
Blackwater fever; its etiology and treatment. ( 13246757 )
1955
42
Blackwater fever in an African child. ( 13261152 )
1955
43
A fatal case of blackwater fever associated with ingestion of nivaquine. ( 13169242 )
1954
44
Blackwater fever treated with cortisone. ( 13032514 )
1953
45
BLACKWATER fever; clinical, pathological, and diagnostic features. ( 13076562 )
1953
46
Proguanil and blackwater fever. ( 13019138 )
1953
47
Blackwater fever and the intravascular haemolyses. ( 13058138 )
1952
48
Dextran in blackwater fever. ( 13012413 )
1952
49
Blackwater fever apparently precipitated by proguanil. ( 14852178 )
1951
50
Blackwater fever in African children. ( 14830853 )
1951

Variations for Blackwater Fever

Expression for Blackwater Fever

Search GEO for disease gene expression data for Blackwater Fever.

Pathways for Blackwater Fever

Pathways related to Blackwater Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.55 G6PD RPTOR

GO Terms for Blackwater Fever

Cellular components related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.13 CLIC1 HP HPX
2 endocytic vesicle lumen GO:0071682 8.62 HP HPX

Sources for Blackwater Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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