MCID: BLC004
MIFTS: 32

Blackwater Fever

Categories: Blood diseases, Infectious diseases

Aliases & Classifications for Blackwater Fever

MalaCards integrated aliases for Blackwater Fever:

Name: Blackwater Fever 12 54 43 15 17 71
Hemoglobinuric, Malaria 12
Malarial Hemoglobinuria 12
Black Water Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14068
ICD9CM 34 084.8
MeSH 43 D001742
NCIt 49 C34426
SNOMED-CT 67 56625005
UMLS 71 C0005681

Summaries for Blackwater Fever

Disease Ontology : 12 A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax.

MalaCards based summary : Blackwater Fever, also known as hemoglobinuric, malaria, is related to acute kidney failure and hemoglobinuria. An important gene associated with Blackwater Fever is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways is Binding and Uptake of Ligands by Scavenger Receptors. The drugs Ibuprofen and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related phenotypes are Decreased Salmonella proliferation and Increased shRNA abundance

Wikipedia : 74 Blackwater fever is a complication of malaria infection in which red blood cells burst in the... more...

Related Diseases for Blackwater Fever

Graphical network of the top 20 diseases related to Blackwater Fever:



Diseases related to Blackwater Fever

Symptoms & Phenotypes for Blackwater Fever

GenomeRNAi Phenotypes related to Blackwater Fever according to GeneCards Suite gene sharing:

26 (showing 2, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Salmonella proliferation GR00364-A 9.13 CLIC1 MB NTPCR
2 Increased shRNA abundance GR00327-A 8.8 G6PD HPX KIF5B

MGI Mouse Phenotypes related to Blackwater Fever:

45 (showing 1, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.1 CLIC1 G6PD HP HPX LGALS2 MB

Drugs & Therapeutics for Blackwater Fever

Drugs for Blackwater Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 16, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved 15687-27-1 3672
2
Acetaminophen Approved 103-90-2 1983
3
Artesunate Approved, Investigational 88495-63-0 5464098 6917864
4 Antipyretics
5 Analgesics, Non-Narcotic
6 Anti-Infective Agents
7 Anti-Inflammatory Agents, Non-Steroidal
8 Analgesics
9 Cyclooxygenase Inhibitors
10 Antirheumatic Agents
11 Antimalarials
12 Anthelmintics
13 Antiviral Agents
14 Anti-Inflammatory Agents
15 Antiparasitic Agents
16 Antiprotozoal Agents

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Paracetamol Effect on Oxidative Stress and Renal Function in Severe Falciparum Malaria With Intravascular Haemolysis: A Randomised Controlled Clinical Trial Completed NCT01641289 Paracetamol;No Paracetamol

Search NIH Clinical Center for Blackwater Fever

Cochrane evidence based reviews: blackwater fever

Genetic Tests for Blackwater Fever

Anatomical Context for Blackwater Fever

MalaCards organs/tissues related to Blackwater Fever:

40
Kidney

Publications for Blackwater Fever

Articles related to Blackwater Fever:

(showing 196, show less)
# Title Authors PMID Year
1
Glucose-6-phosphate dehydrogenase (G6PD) mutations and haemoglobinuria syndrome in the Vietnamese population. 61 54
19589177 2009
2
The role of glucose-6-phosphate dehydrogenase deficiency in blackwater fever. 54 61
9402415 1997
3
Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. 61 54
7859663 1994
4
Blackwater fever in Ugandan children with severe anemia is associated with poor post-discharge outcomes. A prospective cohort study. 61
31300826 2019
5
A Report of Four Cases of Blackwater Fever after Quinine Treatment at Zinder National Hospital, Niger Republic. 61
31534807 2019
6
Severe delayed haemolytic anaemia associated with artemether-lumefantrine treatment of malaria in a Japanese traveller. 61
29127021 2018
7
Blackwater fever in a non-immune patient with Plasmodium falciparum malaria after intravenous artesunate. 61
29394389 2018
8
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment. 61
29338726 2018
9
The Multifactorial Epidemiology of Blackwater Fever. 61
29016337 2017
10
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. 61
28362936 2017
11
[A Case of Blackwater Fever after Treatment for Plasmodium falciparum Malaria]. 61
30212049 2016
12
Historical Review: Problematic Malaria Prophylaxis with Quinine. 61
27185766 2016
13
Dr John Dickinson (1832-1863): The man behind the bird. 61
24906404 2016
14
Blood Trials: Transfusions, Injections, and Experiments in Africa, 1890-1920. 61
26514397 2016
15
An unusual case of blackwater fever. 61
27514973 2016
16
[A rare case of suppurative mesenteric adenitis associated with intussusception in a child: a clinical case]. 61
27279973 2016
17
Severe malaria in children: A descriptive report from Kinshasa, the Democratic Republic of Congo. 61
25957436 2015
18
[Blackwater fever (BWF) of late revelation about a case at the University Hospital of Dakar]. 61
26966497 2015
19
Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. 61
24629047 2014
20
Autoimmunity: from black water fever to regulatory function. 61
24491820 2014
21
[Acute renal failure and severe malaria in Congolese children living in Kinshasa, Democratic Republic of Congo]. 61
23402997 2013
22
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. 61
23767699 2013
23
Malaria, clinical features and acute crisis in children suffering from sickle cell disease in resource-limited settings: a retrospective description of 90 cases. 61
23816320 2013
24
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. 61
23800033 2013
25
Blackwater fever like in murine malaria. 61
23254588 2013
26
Acute renal failure in Congolese children: a tertiary institution experience. 61
22931368 2012
27
Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial. 61
22412067 2012
28
[Haemolytic crisis of blackwater fever following artemether-lumefantrine intake]. 61
20658275 2010
29
Blackwater fever: divine retribution or genetic happenstance? 61
20957905 2010
30
An imported case of P. falciparum malaria presenting as black water fever with acute renal failure. 61
19945017 2009
31
Blackwater fever: the rise and fall of an exotic disease. 61
20013744 2009
32
[Blackwater fever in children during cerebral malaria: 3 case reports in Bamako]. 61
17524629 2007
33
[A mild blackwater fever]. 61
16806779 2006
34
Severe malaria--analysis of prognostic symptoms and signs in 169 patients treated in Gdynia in 1991-2005. 61
17312703 2006
35
Blackwater fever in children, Burundi. 61
16022794 2005
36
Malaria: a 10-year (1994-2003) retrospective study at University Malaya Medical Center (UMMC), Kuala Lumpur, Malaysia. 61
16438181 2005
37
[Blackwater fever during antimalarial treatment in Abidjan (West Africa): report of 41 cases]. 61
15787264 2004
38
Case report: combination artemether-lumefantrine and haemolytic anaemia following a malarial attack. 61
15259474 2003
39
[Methemalbuminnemia after massive hemolysis during blackwater fever]. 61
12805012 2003
40
Epidemiological and clinical aspects of blackwater fever among African children suffering frequent malaria attacks. 61
14584376 2003
41
[Nine cases of falciparum malaria with blackwater fever in Mali]. 61
14628359 2003
42
[Blackwater fever: a case report]. 61
15849955 2003
43
[Blackwater fever]. 61
12355996 2002
44
Blackwater fever treated with artemether. 61
11996443 2001
45
Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review. 61
11283802 2001
46
Severe falciparum malarial complications in Ukhrul, Manipur. 61
11258490 2000
47
[Blackwater fever in adults with sickle cell anemia. Two fatal cases]. 61
11100442 2000
48
[Clinical study on 24 cases of eclampsia with cerebral malaria]. 61
11360644 1999
49
Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives. 61
10348227 1999
50
Acute intravascular haemolysis (blackwater fever) after antimalarial treatment. 61
10203176 1999
51
Recurrence of blackwater fever: triggering of relapses by different antimalarials. 61
9735933 1998
52
Blackwater fever: a fatal case. 61
9434932 1997
53
Is halofantrine still advisable in malaria attacks? 61
9625944 1997
54
Blackwater fever in southern Vietnam: a prospective descriptive study of 50 cases. 61
8953071 1996
55
Imported cerebral malaria complicated with glucose-6-phosphate dehydrogenase deficiency. 61
8952432 1996
56
Blackwater fever after halofantrine. 61
8637361 1996
57
Blackwater fever and acute renal failure in expatriates in Africa. 61
8827999 1996
58
An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire. 61
7794063 1995
59
[Blackwater fever: a French episode drawn from the research of Alexandre Yersin]. 61
8851059 1995
60
[Blackwater fever after ingestion of mefloquine. Three cases]. 61
8493208 1993
61
[Tropical malaria and sickle-cell anemia: a tropical surprise]. 61
1440554 1992
62
Blackwater fever caused by Plasmodium vivax infection in the acquired immune deficiency syndrome. 61
3130932 1988
63
Endotoxaemia in complicated falciparum malaria. 61
3076705 1988
64
Quinine and the mystery of blackwater fever. 61
3321835 1987
65
Drug-induced haemolysis masquerading as blackwater fever. 61
3690650 1987
66
[Cerebral malaria and blackwater fever in Greenland]. 61
6845484 1983
67
Splenectomy and blackwater fever. 61
7104241 1982
68
Acute renal failure in tropical Africa. 61
1260396 1976
69
Acute renal failure and typhoid fever. 61
1234676 1975
70
[Cerebral tropical malaria with blackwater fever. A current diagnostic and therapeutic problem]. 61
4612704 1974
71
Blackwater fever in Kenya: problems of etiology. 61
4578485 1973
72
Erythrocyte morphology in blackwater fever. 61
5485713 1970
73
More blackwater fever. 61
5797772 1969
74
Autoimmune disease and blackwater fever. 61
4179535 1969
75
Oliguric renal failure in blackwater fever. 61
4881129 1968
76
The kidney in blackwater fever: light and electron microscopic observations. 61
4171380 1968
77
A case of blackwater fever. 61
5661211 1968
78
BLACKWATER FEVER AFTER THE USE OF CHLOROQUINE-PYRIMETHAMINE. 61
14055154 1963
79
Blackwater fever in Southern Rhodesia in retrospect. 61
13975090 1962
80
The artificial kidney in malaria and blackwater fever. 61
14450615 1962
81
The role of quinine in haemolysis. 61
13536282 1958
82
Treatment of blackwater fever with prednisone. 61
13386233 1956
83
Blackwater fever in an African child. 61
13261152 1955
84
[Malarial hemoglobinuria]. 61
13264454 1955
85
Blackwater fever; its etiology and treatment. 61
13246757 1955
86
[Blackwater fever and leptospira]. 61
14388462 1955
87
A fatal case of blackwater fever associated with ingestion of nivaquine. 61
13169242 1954
88
[Blackwater fever; attempt at cortisone therapy]. 61
13182470 1954
89
Blackwater fever treated with cortisone. 61
13032514 1953
90
Proguanil and blackwater fever. 61
13019138 1953
91
BLACKWATER fever; clinical, pathological, and diagnostic features. 61
13076562 1953
92
Dextran in blackwater fever. 61
13012413 1952
93
Blackwater fever and the intravascular haemolyses. 61
13058138 1952
94
[Clinical aspects of blackwater fever with suggestions for treatment]. 61
13058139 1952
95
Observations on the mechanism of haemolysis in blackwater fever. 61
14908092 1951
96
BLACKWATER fever. 61
14848575 1951
97
Blackwater fever apparently precipitated by proguanil. 61
14852178 1951
98
Blackwater fever in African children. 61
14830853 1951
99
[Respiratory metabolism in course of blackwater fever with grave anuria cured by exchange transfusion and nephroperitoneum]. 61
14834220 1951
100
Observations on the mechanism of blackwater fever; an experimental study in the monkey. 61
14804092 1950
101
The correlation between blackwater fever, malaria, quinine and atebrin. 61
24539931 1950
102
A heretofore unreported agglutinable human blood factor and its possible relationship to blackwater fever. 61
14771390 1950
103
[Leptospirosis; Weil-Vasälev's disease and blackwater fever]. 61
15414842 1950
104
Blackwater fever in West Africa, 1941-45; blackwater fever in European military personnel. 61
15393586 1949
105
Blackwater fever in West Africa; 1941-45; blackwater fever in African military personnel. 61
15393593 1949
106
Hemoglobinuria, blackwater fever, in monkeys; a consideration of the disease in man. 61
18113078 1949
107
A case of blackwater fever. 61
18117888 1949
108
Proguanil and blackwater fever. 61
18224799 1949
109
Malaria and blackwater fever in Macedonia and Thrace in relation to DDT. 61
18891441 1948
110
Experiments on the relation of haemoglobinuria and anuria with reference to blackwater fever. 61
18902131 1947
111
A hepatic syndrome of wide distribution illustrated by lesions in malaria and blackwater fever. 61
20272628 1947
112
Blackwater Fever. 61
29014919 1947
113
A Case of Blackwater Fever. 61
29014935 1947
114
Attempts to induce blackwater fever experimentally. 61
20249286 1947
115
A case of blackwater fever during mepacrine therapy. 61
20286135 1946
116
Blackwater fever; modern theories; a critical review. 61
21003289 1946
117
A case of blackwater fever observed in Britain. 61
20999638 1946
118
[Blackwater fever after delivery]. 61
20985982 1946
119
Blackwater fever in Rhodes. 61
20988795 1946
120
Blackwater fever. 61
20994534 1946
121
Blackwater Fever in West Africa. 61
20785946 1945
122
A case of blackwater fever in an African girl. 61
20293964 1945
123
Survival of transfused red cells in blackwater fever circulation and of blackwater red cells in normal circulation (preliminary report). 61
20293958 1945
124
Amœbiasis and Blackwater Fever. 61
29015782 1945
125
Report of an attack of blackwater fever subsequent to induced malaria. 61
21005332 1945
126
The Rh factor in blackwater fever; a preliminary note. 61
21005339 1945
127
On a fatal case of blackwater fever with pseudo-methaemoglobinemia. 61
21028572 1945
128
Autoantigens and autoantibodies in the pathogenesis of disease with special refenence to blackwater fever. 61
21020353 1945
129
Blackwater Fever and Methæmalbumin. 61
29014105 1944
130
Treatment of Blackwater Fever. 61
29012099 1944
131
Blackwater Fever in Darjeeling-Terai. 61
29013497 1941
132
Blackwater Fever in the Hills. 61
29013631 1941
133
Vitex Peduncularis in the Treatment of Blackwater Fever. 61
29013959 1940
134
Vitex Peduncularis in the Treatment of Blackwater Fever. 61
29013933 1940
135
BLACKWATER FEVER. 61
20780859 1937
136
The Ætiology of Blackwater Fever. 61
29012965 1936
137
Recent Researches on Blackwater Fever. 61
29009305 1933
138
Three Fatal Cases of Blackwater Fever. 61
29009300 1933
139
The Ætiology of Blackwater Fever. 61
29011056 1932
140
A Case of Blackwater Fever Treated by Atebrin. 61
29010900 1932
141
A Case of Blackwater Fever Precipitated by Ptomaine Poisoning Due to Unclean Degchies. 61
29010895 1932
142
A Case of Blackwater Fever. 61
29008931 1930
143
Retention of Urine in Blackwater Fever. 61
29009696 1929
144
Observations on 8 Cases of Blackwater Fever, Treated with Serums and Alkalies. 61
29011542 1928
145
THE MECHANISM OF BLACKWATER FEVER AND CERTAIN ALLIED CONDITIONS. 61
20774047 1928
146
A Case of Identical Delirium in Repeated Attacks of BlackWater Fever at Long Intervals. 61
29011684 1928
147
A Note on the Intravenous Administration of Sodium Bicarbonate in Blackwater Fever. 61
29011493 1928
148
Blackwater Fever and Malaria. 61
29010782 1927
149
A Case of Blackwater Fever. 61
29010496 1927
150
A Case of Blackwater Fever Successfully Treated by Injections of Quinine Bihydrochloride and Normal Horse Serum. 61
29011137 1926
151
SOME OBSERVATIONS ON BLACKWATER FEVER. 61
20771869 1925
152
Researches on Blackwater Fever in Southern Rhodesia during the Years 1922 and 1923. 61
19984109 1924
153
BLACKWATER FEVER: ITS ETIOLOGY AND PARASITOLOGY. 61
20771378 1923
154
Blackwater Fever as It Occurs in the Duars and Its Treatment. 61
29008326 1922
155
Blackwater Fever in Khondmals, Orissa. 61
29007150 1921
156
Blackwater Fever. 61
29007215 1921
157
A PRELIMINARY NOTE ON THE USE OF VITEX PEDUNCULARIS IN MALARIAL FEVER AND IN BLACKWATER FEVER. 61
20770160 1921
158
Blackwater Fever, Notes on. 61
29583545 1921
159
NOTES ON BLACKWATER FEVER. 61
20770054 1920
160
Blackwater Fever. 61
20474711 1920
161
BLACKWATER FEVER IN MACEDONIA. 61
20769948 1920
162
Blackwater Fever. 61
29008259 1920
163
Blackwater Fever in the Agency of Ganjam District. 61
29006791 1918
164
INTRAVENOUS SALINE IN BLACKWATER FEVER. 61
20769218 1918
165
A Glance at Blackwater Fever. 61
29008698 1916
166
Comments on Case of Blackwater Fever. 61
29008155 1916
167
A REPUTED SPECIFIC FOR BLACKWATER FEVER. 61
17817189 1916
168
Blackwater Fever. 61
29007083 1915
169
Is Syphilis a Factor in Blackwater Fever? 61
29005938 1913
170
Some Unusual Forms of the Parasite of Pernicious Malaria, Found in Blackwater Fever. 61
29005921 1913
171
A Case of Blackwater Fever in England. 61
20765693 1911
172
Observations on the Inhibitory Influence exerted by Hypertonic Saline Solutions and Calcium Chloride Solutions on the Action of Specific Haemolysins, with Suggestions as to the Therapy of Blackwater Fever. 61
16742160 1911
173
Blackwater Fever. 61
29004511 1910
174
Blackwater Fever and Quinine. 61
29004330 1909
175
Blackwater Fever, Hæmolysis and Quinine. 61
29005183 1909
176
A Case of Blackwater Fever. 61
29005244 1909
177
Is Blackwater Fever a Form of Malaria? 61
29815858 1908
178
The Hearsey Treatment of Blackwater Fever. 61
29815875 1908
179
Quinine Sulphate and Blackwater Fever. 61
29006467 1908
180
Blackwater Fever. 61
29006418 1908
181
Kala-Azar and Blackwater Fever. 61
29006431 1908
182
Preliminary Note on the Etiology of Blackwater Fever. 61
29006456 1908
183
Preliminary Note on Quinine Sulphate as a Factor in the Causation of BlackWater Fever. 61
29004936 1907
184
Blackwater Fever in Burma. 61
29004967 1907
185
Blackwater Fever: The Liverpool School's Views. 61
29005015 1907
186
NOTES ON A CASE OF QUININE HAEMOGLOBINURIA OR BLACKWATER FEVER. 61
20762926 1906
187
Notes on a Case of Blackwater Fever. 61
28896129 1904
188
EXPERIMENTAL HAEMOGLOBINURIA IN A CASE OF BLACKWATER FEVER. 61
20760898 1903
189
Quinine and Blackwater Fever. 61
29815112 1903
190
BLACKWATER FEVER. 61
20760014 1902
191
Observations on Blackwater Fever. 61
20759804 1901
192
Five Cases of So-Called Blackwater Fever. 61
20758589 1899
193
The Parasite of Malaria in the Tissues in a Fatal Case of Blackwater Fever. 61
20758514 1899
194
Hæmaturia or "Blackwater" Fever in India. 61
29002199 1899
195
Blackwater Fever. 61
29419137 1899
196
African Haemoglobinuric Fever, Commonly Called Blackwater Fever. 61
20758062 1898

Variations for Blackwater Fever

Expression for Blackwater Fever

Search GEO for disease gene expression data for Blackwater Fever.

Pathways for Blackwater Fever

Pathways related to Blackwater Fever according to GeneCards Suite gene sharing:

(showing 1, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.64 HPX HP

GO Terms for Blackwater Fever

Cellular components related to Blackwater Fever according to GeneCards Suite gene sharing:

(showing 4, show less)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.55 MB HPX HP G6PD CLIC1
2 centriolar satellite GO:0034451 9.26 KIF5B G6PD
3 blood microparticle GO:0072562 9.13 HPX HP CLIC1
4 endocytic vesicle lumen GO:0071682 8.62 HPX HP

Biological processes related to Blackwater Fever according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 response to hydrogen peroxide GO:0042542 8.62 MB HP

Sources for Blackwater Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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