MCID: BLC004
MIFTS: 32

Blackwater Fever

Categories: Blood diseases, Infectious diseases

Aliases & Classifications for Blackwater Fever

MalaCards integrated aliases for Blackwater Fever:

Name: Blackwater Fever 12 55 44 15 17 72
Hemoglobinuric, Malaria 12
Malarial Hemoglobinuria 12
Black Water Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14068
ICD9CM 35 084.8
MeSH 44 D001742
NCIt 50 C34426
SNOMED-CT 68 56625005
UMLS 72 C0005681

Summaries for Blackwater Fever

Disease Ontology : 12 A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax.

MalaCards based summary : Blackwater Fever, also known as hemoglobinuric, malaria, is related to glucosephosphate dehydrogenase deficiency and methemoglobinemia. An important gene associated with Blackwater Fever is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways are Regulation of TP53 Activity and TP53 Regulates Metabolic Genes. The drugs Acetaminophen and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related phenotypes are Increased shRNA abundance and hematopoietic system

Wikipedia : 75 Blackwater fever is a complication of malaria infection in which red blood cells burst in the... more...

Related Diseases for Blackwater Fever

Graphical network of the top 20 diseases related to Blackwater Fever:



Diseases related to Blackwater Fever

Symptoms & Phenotypes for Blackwater Fever

GenomeRNAi Phenotypes related to Blackwater Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 G6PD HPX KIF5B

MGI Mouse Phenotypes related to Blackwater Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CD1D CDKN2A CLIC1 G6PD HP HPX
2 homeostasis/metabolism MP:0005376 9.56 CD1D CDKN2A CLIC1 G6PD HP HPX
3 liver/biliary system MP:0005370 9.02 CD1D CDKN2A HP HPX RPTOR

Drugs & Therapeutics for Blackwater Fever

Drugs for Blackwater Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved 103-90-2 1983
2
Ibuprofen Approved 15687-27-1 3672
3
Artesunate Approved, Investigational 88495-63-0 5464098 6917864
4 Analgesics
5 Analgesics, Non-Narcotic
6 Cyclooxygenase Inhibitors
7 Peripheral Nervous System Agents
8 Anti-Infective Agents
9 Anti-Inflammatory Agents, Non-Steroidal
10 Anthelmintics
11 Anti-Inflammatory Agents
12 Antiparasitic Agents
13 Antimalarials
14 Antiviral Agents
15 Antipyretics
16 Antirheumatic Agents
17 Antiprotozoal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paracetamol Effect on Oxidative Stress and Renal Function in Severe Falciparum Malaria With Intravascular Haemolysis: A Randomised Controlled Clinical Trial Completed NCT01641289 Paracetamol;No Paracetamol

Search NIH Clinical Center for Blackwater Fever

Cochrane evidence based reviews: blackwater fever

Genetic Tests for Blackwater Fever

Anatomical Context for Blackwater Fever

MalaCards organs/tissues related to Blackwater Fever:

41
Kidney

Publications for Blackwater Fever

Articles related to Blackwater Fever:

(show top 50) (show all 195)
# Title Authors PMID Year
1
Glucose-6-phosphate dehydrogenase (G6PD) mutations and haemoglobinuria syndrome in the Vietnamese population. 9 38
19589177 2009
2
The role of glucose-6-phosphate dehydrogenase deficiency in blackwater fever. 9 38
9402415 1997
3
Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. 9 38
7859663 1994
4
Blackwater fever in Ugandan children with severe anemia is associated with poor post-discharge outcomes. A prospective cohort study. 38
31300826 2019
5
Severe delayed haemolytic anaemia associated with artemether-lumefantrine treatment of malaria in a Japanese traveller. 38
29127021 2018
6
Blackwater fever in a non-immune patient with Plasmodium falciparum malaria after intravenous artesunate. 38
29394389 2018
7
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment. 38
29338726 2018
8
The Multifactorial Epidemiology of Blackwater Fever. 38
29016337 2017
9
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. 38
28362936 2017
10
[A Case of Blackwater Fever after Treatment for Plasmodium falciparum Malaria]. 38
30212049 2016
11
Dr John Dickinson (1832-1863): The man behind the bird. 38
24906404 2016
12
Historical Review: Problematic Malaria Prophylaxis with Quinine. 38
27185766 2016
13
Blood Trials: Transfusions, Injections, and Experiments in Africa, 1890-1920. 38
26514397 2016
14
An unusual case of blackwater fever. 38
27514973 2016
15
[A rare case of suppurative mesenteric adenitis associated with intussusception in a child: a clinical case]. 38
27279973 2016
16
Severe malaria in children: A descriptive report from Kinshasa, the Democratic Republic of Congo. 38
25957436 2015
17
[Blackwater fever (BWF) of late revelation about a case at the University Hospital of Dakar]. 38
26966497 2015
18
Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. 38
24629047 2014
19
Autoimmunity: from black water fever to regulatory function. 38
24491820 2014
20
[Acute renal failure and severe malaria in Congolese children living in Kinshasa, Democratic Republic of Congo]. 38
23402997 2013
21
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. 38
23767699 2013
22
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. 38
23800033 2013
23
Malaria, clinical features and acute crisis in children suffering from sickle cell disease in resource-limited settings: a retrospective description of 90 cases. 38
23816320 2013
24
Blackwater fever like in murine malaria. 38
23254588 2013
25
Acute renal failure in Congolese children: a tertiary institution experience. 38
22931368 2012
26
Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial. 38
22412067 2012
27
[Haemolytic crisis of blackwater fever following artemether-lumefantrine intake]. 38
20658275 2010
28
Blackwater fever: divine retribution or genetic happenstance? 38
20957905 2010
29
Blackwater fever: the rise and fall of an exotic disease. 38
20013744 2009
30
An imported case of P. falciparum malaria presenting as black water fever with acute renal failure. 38
19945017 2009
31
[Blackwater fever in children during cerebral malaria: 3 case reports in Bamako]. 38
17524629 2007
32
[A mild blackwater fever]. 38
16806779 2006
33
Severe malaria--analysis of prognostic symptoms and signs in 169 patients treated in Gdynia in 1991-2005. 38
17312703 2006
34
Blackwater fever in children, Burundi. 38
16022794 2005
35
Malaria: a 10-year (1994-2003) retrospective study at University Malaya Medical Center (UMMC), Kuala Lumpur, Malaysia. 38
16438181 2005
36
[Blackwater fever during antimalarial treatment in Abidjan (West Africa): report of 41 cases]. 38
15787264 2004
37
Case report: combination artemether-lumefantrine and haemolytic anaemia following a malarial attack. 38
15259474 2003
38
[Methemalbuminnemia after massive hemolysis during blackwater fever]. 38
12805012 2003
39
Epidemiological and clinical aspects of blackwater fever among African children suffering frequent malaria attacks. 38
14584376 2003
40
[Nine cases of falciparum malaria with blackwater fever in Mali]. 38
14628359 2003
41
[Blackwater fever: a case report]. 38
15849955 2003
42
[Blackwater fever]. 38
12355996 2002
43
Blackwater fever treated with artemether. 38
11996443 2001
44
Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review. 38
11283802 2001
45
Severe falciparum malarial complications in Ukhrul, Manipur. 38
11258490 2000
46
[Blackwater fever in adults with sickle cell anemia. Two fatal cases]. 38
11100442 2000
47
[Clinical study on 24 cases of eclampsia with cerebral malaria]. 38
11360644 1999
48
Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives. 38
10348227 1999
49
Acute intravascular haemolysis (blackwater fever) after antimalarial treatment. 38
10203176 1999
50
Recurrence of blackwater fever: triggering of relapses by different antimalarials. 38
9735933 1998

Variations for Blackwater Fever

Expression for Blackwater Fever

Search GEO for disease gene expression data for Blackwater Fever.

Pathways for Blackwater Fever

GO Terms for Blackwater Fever

Cellular components related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.13 HPX HP CLIC1
2 endocytic vesicle lumen GO:0071682 8.62 HPX HP

Sources for Blackwater Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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