MCID: BLD040
MIFTS: 24

Bladder Benign Neoplasm

Categories: Blood diseases, Cancer diseases, Genetic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Bladder Benign Neoplasm

MalaCards integrated aliases for Bladder Benign Neoplasm:

Name: Bladder Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050623
ICD10 33 D30.3

Summaries for Bladder Benign Neoplasm

Disease Ontology : 12 A urinary system benign neoplasm located in the bladder including papillomas, leiomyomas, fibromas, hemangiomas, neurofibromas and lipomas.

MalaCards based summary : Bladder Benign Neoplasm is related to rete testis adenoma and childhood endodermal sinus tumor. An important gene associated with Bladder Benign Neoplasm is PAX8 (Paired Box 8), and among its related pathways/superpathways is ID signaling pathway. Affiliated tissues include kidney, ovary and prostate, and related phenotype is renal/urinary system.

Related Diseases for Bladder Benign Neoplasm

Diseases in the Bladder Cancer family:

Bladder Benign Neoplasm Bladder Carcinoma in Situ

Diseases related to Bladder Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 rete testis adenoma 10.1 PAX2 PAX8
2 childhood endodermal sinus tumor 10.1 PAX2 PAX8
3 rete testis neoplasm 10.0 PAX2 PAX8
4 endosalpingiosis 10.0 KRT7 PAX8
5 retinal hemangioblastoma 10.0 PAX2 PAX8
6 renal pelvis adenocarcinoma 10.0 KRT7 PAX8
7 sensory organ benign neoplasm 10.0 KRT7 PAX8
8 deafness, autosomal dominant 10 10.0 PAX2 PAX8
9 endocervical carcinoma 10.0 KRT7 PAX8
10 renal pelvis carcinoma 10.0 KRT7 PAX8
11 peritoneum cancer 10.0 KRT7 PAX8
12 urethral diverticulum 10.0 KRT7 PAX8
13 collecting duct carcinoma 10.0 KRT7 PAX8
14 cervical adenosquamous carcinoma 10.0 KRT7 PAX8
15 ovarian cancer 1 10.0 KRT7 PAX8
16 malignant ovarian surface epithelial-stromal neoplasm 10.0 KRT7 PAX8
17 ovary epithelial cancer 10.0 KRT7 PAX8
18 thymus cancer 9.9 KRT7 PAX8
19 papillary carcinoma 9.9 KRT7 PAX8
20 bladder leiomyoma 9.9 IGF2 PAAF1
21 renal cell carcinoma, papillary, 1 9.9 KRT7 PAX8
22 nephrogenic adenoma of urinary bladder 9.9 KRT7 PAX2 PAX8
23 nephrogenic adenoma 9.8 KRT7 PAX2 PAX8
24 kidney benign neoplasm 9.8 KRT7 PAX2 PAX8
25 endocervical adenocarcinoma 9.8 KRT7 PAX2 PAX8
26 prostatic acinar adenocarcinoma 9.8 KRT7 PAX2 PAX8
27 adenocarcinoma in situ 9.8 KRT7 PAX2 PAX8
28 nephrogenic adenofibroma 9.8 KRT7 PAX2 PAX8
29 ovarian brenner tumor 9.8 KRT7 PAX2 PAX8
30 clear cell adenocarcinoma 9.8 KRT7 PAX2 PAX8
31 clear cell renal cell carcinoma 9.8 KRT7 PAX2 PAX8
32 renal cell carcinoma, nonpapillary 9.8 KRT7 PAX2 PAX8
33 endocrine gland cancer 9.8 IGF2 PAX8
34 hepatoblastoma 9.8 IGF2 KRT7
35 papilloma 9.6 IGF2 KRT7
36 wilms tumor 1 9.5 IGF2 KRT7 PAX2 PAX8

Graphical network of the top 20 diseases related to Bladder Benign Neoplasm:



Diseases related to Bladder Benign Neoplasm

Symptoms & Phenotypes for Bladder Benign Neoplasm

MGI Mouse Phenotypes related to Bladder Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 IGF2 KRT7 PAX2 PAX8

Drugs & Therapeutics for Bladder Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Bladder Benign Neoplasm

Genetic Tests for Bladder Benign Neoplasm

Anatomical Context for Bladder Benign Neoplasm

MalaCards organs/tissues related to Bladder Benign Neoplasm:

41
Kidney, Ovary, Prostate, Testis, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Bladder Benign Neoplasm:

19
The Bladder Including Papillomas

Publications for Bladder Benign Neoplasm

Variations for Bladder Benign Neoplasm

Cosmic variations for Bladder Benign Neoplasm:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM483 HRAS urinary tract,bladder,other,neoplasm c.35G>T p.G12V 11:534288-534288 6
2 COSM499 HRAS urinary tract,bladder,other,neoplasm c.182A>G p.Q61R 11:533874-533874 6
3 COSM498 HRAS urinary tract,bladder,other,neoplasm c.182A>T p.Q61L 11:533874-533874 6
4 COSM496 HRAS urinary tract,bladder,other,neoplasm c.181C>A p.Q61K 11:533875-533875 6
5 COSM488 HRAS urinary tract,bladder,other,neoplasm c.37G>T p.G13C 11:534286-534286 6

Expression for Bladder Benign Neoplasm

Search GEO for disease gene expression data for Bladder Benign Neoplasm.

Pathways for Bladder Benign Neoplasm

Pathways related to Bladder Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.83 PAX2 PAX8

GO Terms for Bladder Benign Neoplasm

Biological processes related to Bladder Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inner ear morphogenesis GO:0042472 9.58 PAX2 PAX8
2 branching involved in ureteric bud morphogenesis GO:0001658 9.57 PAX2 PAX8
3 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.56 PAX2 PAX8
4 urogenital system development GO:0001655 9.55 PAX2 PAX8
5 mesonephros development GO:0001823 9.54 PAX2 PAX8
6 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.52 PAX2 PAX8
7 pronephros development GO:0048793 9.51 PAX2 PAX8
8 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.49 PAX2 PAX8
9 metanephric epithelium development GO:0072207 9.48 PAX2 PAX8
10 metanephric distal convoluted tubule development GO:0072221 9.46 PAX2 PAX8
11 metanephric nephron tubule formation GO:0072289 9.43 PAX2 PAX8
12 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.4 PAX2 PAX8
13 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.37 PAX2 PAX8
14 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.32 PAX2 PAX8
15 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.26 PAX2 PAX8
16 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX2 PAX8
17 positive regulation of metanephric DCT cell differentiation GO:2000594 8.96 PAX2 PAX8
18 pronephric field specification GO:0039003 8.62 PAX2 PAX8

Sources for Bladder Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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