MCID: BLD041
MIFTS: 33

Bladder Calculus

Categories: Nephrological diseases

Aliases & Classifications for Bladder Calculus

MalaCards integrated aliases for Bladder Calculus:

Name: Bladder Calculus 12 15 17
Urinary Bladder Calculi 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11355
MeSH 45 D001744
SNOMED-CT 69 70650003
ICD10 34 N21.0
UMLS 74 C0005683

Summaries for Bladder Calculus

MalaCards based summary : Bladder Calculus, also known as urinary bladder calculi, is related to shipyard eye and fungal esophagitis. An important gene associated with Bladder Calculus is TPRKB (TP53RK Binding Protein), and among its related pathways/superpathways is tRNA processing. The drugs Gemcitabine and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include prostate, kidney and liver.

Related Diseases for Bladder Calculus

Diseases related to Bladder Calculus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 shipyard eye 10.2 OSGEP TP53RK
2 fungal esophagitis 10.1 ATP12A ATP4A
3 diclofenac allergy 10.1 ATP12A ATP4A
4 gastroduodenal crohn's disease 10.1 ATP12A ATP4A
5 neonatal candidiasis 10.1 ATP12A ATP4A
6 photoallergic dermatitis 10.1 ATP12A ATP4A
7 squamous papillomatosis 10.1 ATP12A ATP4A
8 toxic megacolon 10.1 ATP12A ATP4A
9 aspiration pneumonitis 10.0 ATP12A ATP4A
10 gastrointestinal neuroendocrine benign tumor 10.0 ATP12A ATP4A
11 gastric antral vascular ectasia 10.0 ATP12A ATP4A
12 granulomatous gastritis 10.0 ATP12A ATP4A
13 esophageal candidiasis 10.0 ATP12A ATP4A
14 gastric neuroendocrine neoplasm 10.0 ATP12A ATP4A
15 acute laryngitis 10.0 ATP12A ATP4A
16 laryngitis 10.0 ATP12A ATP4A
17 duodenitis 10.0 ATP12A ATP4A
18 rumination disorder 10.0 ATP12A ATP4A
19 active peptic ulcer disease 10.0 ATP12A ATP4A
20 congenital disorder of deglycosylation 10.0 ATP12A ATP4A
21 ischemic neuropathy 10.0 ATP12A ATP4A
22 bile reflux 10.0 ATP12A ATP4A
23 capillary disease 10.0 ATP12A ATP4A
24 peptic esophagitis 10.0 ATP12A ATP4A
25 ureterocele 10.0
26 inguinal hernia 10.0
27 dyskinesia of esophagus 10.0 ATP12A ATP4A
28 anismus 10.0 ATP12A ATP4A
29 postsurgical hypothyroidism 10.0 ATP12A ATP4A
30 lymphocytic colitis 10.0 ATP12A ATP4A
31 clostridium difficile colitis 10.0 ATP12A ATP4A
32 diarrhea 1, secretory chloride, congenital 10.0 ATP12A ATP4A
33 esophagitis, eosinophilic, 1 10.0 ATP12A ATP4A
34 microscopic colitis 10.0 ATP12A ATP4A
35 chronic laryngitis 10.0 ATP12A ATP4A
36 eosinophilic gastritis 10.0 ATP12A ATP4A
37 esophagus adenocarcinoma 10.0 ATP12A ATP4A
38 chronic intestinal vascular insufficiency 10.0 ATP12A ATP4A
39 polyposis, skin pigmentation, alopecia, and fingernail changes 10.0 ATP12A ATP4A
40 jejunoileitis 10.0 ATP12A ATP4A
41 adenocarcinoma 10.0
42 pancreatic steatorrhea 10.0 ATP12A ATP4A
43 esophageal varix 10.0 ATP12A ATP4A
44 gastric lymphoma 10.0 ATP12A ATP4A
45 myopathy, x-linked, with excessive autophagy 10.0 ATP12A ATP4A
46 aspiration pneumonia 10.0 ATP12A ATP4A
47 intestinal volvulus 10.0 LAGE3 TP53RK TPRKB WDR73
48 blind loop syndrome 9.9 ATP12A ATP4A
49 functional gastric disease 9.9 ATP12A ATP4A
50 trachea adenoid cystic carcinoma 9.9 PGRMC1 SMUG1

Graphical network of the top 20 diseases related to Bladder Calculus:



Diseases related to Bladder Calculus

Symptoms & Phenotypes for Bladder Calculus

Drugs & Therapeutics for Bladder Calculus

Drugs for Bladder Calculus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 3 95058-81-4 60750
2 Anti-Bacterial Agents Phase 3
3 Antiviral Agents Phase 3
4 Antimetabolites Phase 3
5 Anti-Infective Agents Phase 3
6 Immunosuppressive Agents Phase 3
7 Mitomycins Phase 3
8 Antimetabolites, Antineoplastic Phase 3
9 Immunologic Factors Phase 3
10 Nucleic Acid Synthesis Inhibitors Phase 3
11 Alkylating Agents Phase 3
12 Antibiotics, Antitubercular Phase 3
13 Liver Extracts Not Applicable
14 Anesthetics
15 Central Nervous System Depressants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Shock Wave Lithotripsy Versus Visual Cystolitholapaxy in The Management of Patients Presenting With Calcular Acute Urinary Retention: A Randomized Controlled Trial. Unknown status NCT02594631 Phase 4
2 The Bladder Instillation Comparison Study Unknown status NCT02695771 Phase 3 Mitomycin C;Gemcitabine
3 Clipless Laparoscopic Cholecystectomy Using Harmonic Scalpel in Cirrhotic Patients a Prospective Randomized Study Completed NCT01009450 Not Applicable
4 Effects of Thoracic Epidural Anesthesia on Lower Urinary Tract Function Completed NCT00790231
5 Ultrasound-Guided Photoselective Vaporization of the Prostate Completed NCT02346500 Early Phase 1
6 Transurethral Versus Percutaneous Endoscopic Management of Bladder Stones in Boys Recruiting NCT03294239 Not Applicable
7 Evaluation of the NV-VPAC1 Prostate Cancer (PCa) Urine Diagnostic Test in Subjects With Biopsy-confirmed Prostate Cancer, Benign Prostatic Hypertrophy, or Bladder/Kidney Stones. Recruiting NCT03630926
8 Electroacupuncture for Urinary Function of Patients With Chronic Urinary Retention (CUR) Secondary to Lower Motor Neuron Lesion Recruiting NCT03662906 Not Applicable

Search NIH Clinical Center for Bladder Calculus

Cochrane evidence based reviews: urinary bladder calculi

Genetic Tests for Bladder Calculus

Anatomical Context for Bladder Calculus

MalaCards organs/tissues related to Bladder Calculus:

42
Prostate, Kidney, Liver, Testes, Bone

Publications for Bladder Calculus

Articles related to Bladder Calculus:

(show top 50) (show all 65)
# Title Authors Year
1
Bladder calculus leading to acute renal failure in a girl child: a rare cause. ( 28183708 )
2017
2
Large bladder calculus masking a stone in single-system ureterocele. ( 28619970 )
2017
3
Peritoneo-cutaneous fistula from spilled gall bladder calculus following laparoscopic cholecystectomy. ( 28469884 )
2017
4
Comparative study of a new technique using nephroscope and resectoscope sheath and the percutaneous cystolithotripsy for the treatment of bladder calculus. ( 29410893 )
2017
5
Concurrent Laparoscopic Hernia Repair and Cystoscopic Laser Cystolitholaxapy for Urinary Bladder Calculus Contained within a Direct Inguinal Hernia. ( 28958268 )
2017
6
Bladder Calculus at Cesarean Delivery in a Patient with Previous Cystotomy Repair. ( 29999299 )
2017
7
Concurrent Laparoscopic Hernia Repair and Cystoscopic Laser Cystolitholaxapy for Urinary Bladder Calculus Contained within a Direct Inguinal Hernia. ( 30454370 )
2017
8
Bladder calculus resulting from an intravesical translocation of intrauterine contraceptive device in a postmenopausal woman. ( 29963836 )
2016
9
Renal failure with a large bladder calculus related to a foreign body: a case report. ( 25356243 )
2014
10
The recovery of bladder epithelial hyperplasia caused by a melamine diet-induced bladder calculus in mice. ( 24355167 )
2014
11
A huge bladder calculus causing acute renal failure. ( 23532429 )
2013
12
Bladder calculus formation on the tip of a migrated disused ventriculoperitoneal shunt. ( 23701800 )
2013
13
Don't get caught out! A rare case of a calcified urachal remnant mimicking a bladder calculus. ( 23705044 )
2013
14
A case-control study on the association between bladder cancer and prior bladder calculus. ( 23497224 )
2013
15
Bladder calculus secondary to migrated intra-uterine contraceptive device. ( 24431623 )
2013
16
Fragment of pubis through the urinary bladder wall causing urinary bladder calculus. ( 21691725 )
2012
17
Vesicovaginal fistula with large bladder calculus. ( 22510189 )
2012
18
Squamous cell carcinoma associated with large bladder calculus. ( 22507514 )
2012
19
Bladder calculus presenting as recurrent urinary tract infections: a late complication of cervical cerclage placement: a case report. ( 21542538 )
2011
20
Urinary bladder calculi. ( 19345546 )
2011
21
A huge bladder calculus causing acute renal failure. ( 20033143 )
2010
22
Zinc disc implantation model of urinary bladder calculi and humane endpoints. ( 20385652 )
2010
23
End-stage renal disease with giant bladder calculus. ( 25983872 )
2008
24
Vesicocutaneous fistula caused by giant bladder calculus. ( 17457580 )
2007
25
Dermoid cyst of the urinary bladder as a differential diagnosis of bladder calculus: a case report. ( 17592652 )
2007
26
Endoscopic removal of a bladder calculus via flexible sigmoidoscopy. ( 17440847 )
2007
27
Urinary bladder calculi in a sliding vesical-inguinal-scrotal hernia diagnosed preoperatively by plain abdominal radiography. ( 18029327 )
2007
28
Surgical mesh used for an inguinal herniorrhaphy acting as a nidus for a bladder calculus. ( 16984564 )
2006
29
Bladder calculus presenting as excessive masturbation. ( 17315592 )
2006
30
Urinary bladder calculi complicating ventriculo-vesical shunt. ( 16455572 )
2005
31
Bladder calculus resulting from the migration of an intrauterine contraceptive device. ( 15540750 )
2004
32
A large bladder calculus and severe vesicoureteric reflux as seen on Tc-99m MAG3 renography. ( 12394132 )
2002
33
Sonographic appearance of a bladder calculus secondary to a suture from a bladder neck suspension. ( 12418771 )
2002
34
Bladder calculus formation and urinary retention secondary to perforation of a normal bladder by a ventriculoperitoneal shunt. ( 12137842 )
2002
35
Bladder calculus after laparoscopic colposuspension. ( 12521751 )
2002
36
Development of a large bladder calculus on sutures used for pubic bone closure following extrophy repair. ( 11550786 )
2001
37
Calcified nonfunctional paraganglioma of the urinary bladder mistaken as bladder calculus: a diagnostic pitfall. ( 10848713 )
2000
38
Massive bladder calculus as a complication of a titanium prostatic stent. ( 7850341 )
1995
39
Bladder calculus causing vesicovaginal fistula in pregnancy. ( 1933171 )
1991
40
Bladder calculus formation as a complication of the Stamey procedure. ( 2372670 )
1990
41
An unusual bladder calculus. ( 2372687 )
1990
42
Follow-up of patients treated for urinary bladder calculi. ( 2228495 )
1990
43
Bladder calculus. A rare complication of ureteric reimplantation. ( 3342309 )
1988
44
Triamterene bladder calculus. ( 3617299 )
1987
45
Assessment of the effect of androgen and estrogen on the development of prostatic adenocarcinoma and urinary bladder calculi in Nb rats. ( 3658983 )
1987
46
Case profile: large bladder calculus--postcervical cerclage. ( 3962061 )
1986
47
Calcified tumor of the urinary bladder: sonographic diagnosis and distinction from a bladder calculus. ( 3908723 )
1985
48
Giant urinary bladder calculi. ( 4064518 )
1985
49
An unusual bladder calculus. ( 6600047 )
1984
50
Radiopaque suppository simulating bladder calculus. ( 7174943 )
1982

Variations for Bladder Calculus

Expression for Bladder Calculus

Search GEO for disease gene expression data for Bladder Calculus.

Pathways for Bladder Calculus

GO Terms for Bladder Calculus

Cellular components related to Bladder Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 EKC/KEOPS complex GO:0000408 8.92 LAGE3 OSGEP TP53RK TPRKB

Biological processes related to Bladder Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.43 ATP4A ATP12A
2 ATP hydrolysis coupled proton transport GO:0015991 9.4 ATP4A ATP12A
3 cellular sodium ion homeostasis GO:0006883 9.37 ATP4A ATP12A
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP4A ATP12A
5 sodium ion export across plasma membrane GO:0036376 9.26 ATP4A ATP12A
6 cellular potassium ion homeostasis GO:0030007 9.16 ATP4A ATP12A
7 tRNA threonylcarbamoyladenosine modification GO:0002949 8.96 TPRKB OSGEP
8 tRNA processing GO:0008033 8.92 TPRKB TP53RK OSGEP LAGE3

Molecular functions related to Bladder Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Bladder Calculus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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