MCID: BLD041
MIFTS: 29

Bladder Calculus

Categories: Nephrological diseases

Aliases & Classifications for Bladder Calculus

MalaCards integrated aliases for Bladder Calculus:

Name: Bladder Calculus 12 15 17
Urinary Bladder Calculi 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:11355
MeSH 43 D001744
SNOMED-CT 67 70650003
ICD10 32 N21.0
UMLS 71 C0005683

Summaries for Bladder Calculus

MalaCards based summary : Bladder Calculus, also known as urinary bladder calculi, is related to neurogenic bladder and acute cystitis. An important gene associated with Bladder Calculus is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways is tRNA processing. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include prostate, kidney and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Bladder Calculus

Diseases related to Bladder Calculus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 neurogenic bladder 30.1 KLK3 BCL2L10
2 acute cystitis 29.8 MCU KLK3
3 pyuria 29.7 NUMA1 KLK3
4 urethral stricture 29.2 MCU KLK3 BCL2L10
5 cystitis 10.2
6 kidney disease 10.2
7 acute kidney failure 10.2
8 prostatic cyst 10.1 KLK3 BCL2L10
9 bladder neck obstruction 10.1 KLK3 BCL2L10
10 ureterocele 10.1
11 inguinal hernia 10.1
12 urolithiasis 10.1
13 hydronephrosis 10.1
14 vesicoureteral reflux 1 10.0
15 chronic cystitis 10.0
16 prostatic adenoma 10.0
17 adenoma 10.0
18 bladder cancer 9.9
19 schistosoma mansoni infection, susceptibility/ 9.9
20 cystinuria 9.9
21 exstrophy of bladder 9.9
22 coronary heart disease 1 9.9
23 paraganglioma 9.9
24 benign teratoma 9.9
25 prostatic hypertrophy 9.9
26 schistosomiasis 9.9
27 bacteriuria 9.9
28 alcohol use disorder 9.9
29 squamous cell carcinoma 9.9
30 cystic teratoma 9.9
31 mature teratoma 9.9
32 end stage renal disease 9.9
33 48,xyyy 9.9
34 ureteral disease 9.6 MCU CHRM3
35 urethral calculus 9.6 MCU KLK3 CHRM3
36 urethral diverticulum 9.6 MCU KLK3 BCL2L10
37 urethral syndrome 9.4 MCU KLK3
38 primary microcephaly 9.3 TPRKB TP53RK OSGEP LAGE3
39 galloway-mowat syndrome 2 9.0 WDR73 TPRKB TP53RK OSGEP LAGE3
40 galloway-mowat syndrome 9.0 WDR73 TPRKB TP53RK OSGEP LAGE3
41 galloway-mowat syndrome 1 9.0 WDR73 TPRKB TP53RK OSGEP LAGE3
42 microcephaly 8.9 WDR73 TPRKB TP53RK OSGEP LAGE3
43 lower urinary tract calculus 7.8 WDR73 TPRKB TP53RK SLC22A12 MCU LAGE3

Graphical network of the top 20 diseases related to Bladder Calculus:



Diseases related to Bladder Calculus

Symptoms & Phenotypes for Bladder Calculus

GenomeRNAi Phenotypes related to Bladder Calculus according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.47 BCL2L10 SLC22A12
2 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.47 BCL2L10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.47 BCL2L10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.47 SLC22A12
5 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.47 BCL2L10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-17 9.47 SLC22A12
7 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.47 OSGEP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.47 BCL2L10
9 Increased shRNA abundance (Z-score > 2) GR00366-A-212 9.47 OSGEP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.47 BCL2L10
11 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.47 SLC22A12
12 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.47 OSGEP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.47 SLC22A12

Drugs & Therapeutics for Bladder Calculus

Drugs for Bladder Calculus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Transurethral Versus Percutaneous Endoscopic Management of Bladder Stones in Boys: A Comparative Prospective Randomized Study Unknown status NCT03294239
2 Clipless Laparoscopic Cholecystectomy Using Harmonic Scalpel in Cirrhotic Patients a Prospective Randomized Study Completed NCT01009450
3 Evaluation of the NV-VPAC1 Prostate Cancer (PCa) Urine Diagnostic Test in Subjects With Biopsy-confirmed Prostate Cancer, Benign Prostatic Hypertrophy, or Bladder/Kidney Stones Active, not recruiting NCT03630926

Search NIH Clinical Center for Bladder Calculus

Cochrane evidence based reviews: urinary bladder calculi

Genetic Tests for Bladder Calculus

Anatomical Context for Bladder Calculus

MalaCards organs/tissues related to Bladder Calculus:

40
Prostate, Kidney, Liver, Testes, Bone, Spinal Cord

Publications for Bladder Calculus

Articles related to Bladder Calculus:

(show top 50) (show all 200)
# Title Authors PMID Year
1
The story of 'cutting for the stone' - Lithotomy for bladder calculus. 61
31135284 2020
2
Jackstone Calculus. 61
31887350 2020
3
Demonstration of 99mTc-MDP Uptake in a Mobile Urinary Bladder Calculus on SPECT/CT. 61
31693613 2020
4
Extraction of giant bladder calcium oxalate stone: A case report. 61
32146428 2020
5
Technique, complications, and outcomes of pediatric urolithiasis management at a tertiary care hospital: evolving paradigms over the last 15 years. 61
31648889 2019
6
Cystolitholapaxy and laparoscopic sacrocolpopexy in a case of multiple urinary bladder calculi & vault prolapse. 61
31629924 2019
7
Late postcholecystectomy Mirizzi syndrome due to a sessile gall bladder remnant calculus managed by laparoscopic completion cholecystectomy: a feasible surgical option. 61
31387861 2019
8
Self-introduced intravesical magnets in a 3-year-old boy: Case report. 61
31951344 2019
9
[Management of the bladder outlet obstruction associated with BPH in patients with special circumstances and/or complications]. 61
30220535 2018
10
Nephrological and urological complications of homozygous c.974G>A (p.Arg325Gln) OSGEP mutations. 61
30141175 2018
11
Management of a patient with vesicocutaneous fistula presenting 13 years after radiotherapy performed for cervical cancer. 61
29511592 2018
12
Surgical Treatment for Benign Prostatic Hyperplasia: Holmium Laser Enucleation of the Prostate (HoLEP). 61
29578511 2018
13
Survey of polycystic kidney disease and other urinary tract abnormalities using ultrasonography in Persian and Persian related cats in Iran. 61
30065797 2018
14
[GIANT BLADDER CALCULI TREATED WITH SINGLE-STAGE SIMULTANEOUS PERCUTANEOUS SUPRAPUBIC AND TRANSURETHRAL CYSTOLITHOTRIPSY: A CASE REPORT]. 61
31631087 2018
15
Concurrent Laparoscopic Hernia Repair and Cystoscopic Laser Cystolitholaxapy for Urinary Bladder Calculus Contained within a Direct Inguinal Hernia. 61
30454370 2017
16
Large bladder calculus masking a stone in single-system ureterocele. 61
28619970 2017
17
Jack stone in the bladder: case report of a rare entity. 61
28583110 2017
18
Peritoneo-cutaneous fistula from spilled gall bladder calculus following laparoscopic cholecystectomy. 61
28469884 2017
19
Bladder calculus leading to acute renal failure in a girl child: a rare cause. 61
28183708 2017
20
Comparative study of a new technique using nephroscope and resectoscope sheath and the percutaneous cystolithotripsy for the treatment of bladder calculus. 61
29410893 2017
21
Bladder Calculus at Cesarean Delivery in a Patient with Previous Cystotomy Repair. 61
29999299 2017
22
Surgical removal of a large vaginal calculus formed after a tension-free vaginal tape procedure. 61
27324756 2016
23
High (18)F-FDG uptake in urinary calculi on PET/CT: An unrecognized non-malignant accumulation. 61
27423678 2016
24
Endoscopic lithotripsy and vaginal excision of a calcified bladder-mesh extrusion. 61
26740198 2016
25
Human Health Effects of Biphenyl: Key Findings and Scientific Issues. 61
26529796 2016
26
Intravesical migration of an intrauterine device. 61
26724805 2016
27
Endourologic and Open Ureterolithotomy and Common Sheath Reimplant for Large Bladder and Distal Ureteral Calculi. 61
27868099 2016
28
Bladder calculus resulting from an intravesical translocation of intrauterine contraceptive device in a postmenopausal woman. 61
29963836 2016
29
Application of the holmium laser lithotripsy for bladder stones under local anaesthesia: a prospective analysis. 61
25982968 2015
30
Para-meatal urethral cyst with bladder calculi: A case report and review of the literature. 61
26539378 2015
31
Accuracy of ultrasound versus computed tomography urogram in detecting urinary tract calculi. 61
26358021 2015
32
A fragment of Foley catheter balloon as a cause of Bladder stone in woman. 61
26587134 2015
33
The value of respective urodynamic parameters for evaluating the occurrence of complications linked to benign prostatic enlargement. 61
24811567 2014
34
Renal failure with a large bladder calculus related to a foreign body: a case report. 61
25356243 2014
35
The recovery of bladder epithelial hyperplasia caused by a melamine diet-induced bladder calculus in mice. 61
24355167 2014
36
A biological stone from a medieval cemetery in Poland. 61
25275551 2014
37
Primary vaginal calculus in a middle-aged woman with mental and physical disabilities. 61
22872034 2013
38
Bladder calculus formation on the tip of a migrated disused ventriculoperitoneal shunt. 61
23701800 2013
39
Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae. 61
23046500 2013
40
Bladder calculus secondary to migrated intra-uterine contraceptive device. 61
24431623 2013
41
Association of bladder pain syndrome/interstitial cystitis with urinary calculus: a nationwide population-based study. 61
22895546 2013
42
A case-control study on the association between bladder cancer and prior bladder calculus. 61
23497224 2013
43
Don't get caught out! A rare case of a calcified urachal remnant mimicking a bladder calculus. 61
23705044 2013
44
A huge bladder calculus causing acute renal failure. 61
23532429 2013
45
Association between osteoporosis and urinary calculus: evidence from a population-based study. 61
22592810 2013
46
Association between prostate cancer and urinary calculi: a population-based study. 61
23451265 2013
47
Spiculated bladder calculi: the culprit for repeated catheter failure. 61
23984173 2013
48
Association between chronic kidney disease and urinary calculus by stone location: a population-based study. 61
22934937 2012
49
Vesicovaginal fistula with large bladder calculus. 61
22510189 2012
50
Fragment of pubis through the urinary bladder wall causing urinary bladder calculus. 61
21691725 2012

Variations for Bladder Calculus

Expression for Bladder Calculus

Search GEO for disease gene expression data for Bladder Calculus.

Pathways for Bladder Calculus

GO Terms for Bladder Calculus

Cellular components related to Bladder Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 EKC/KEOPS complex GO:0000408 8.92 TPRKB TP53RK OSGEP LAGE3

Biological processes related to Bladder Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-mediated signaling GO:0019722 9.32 MCU CHRM3
2 nucleus organization GO:0006997 9.26 WDR73 NUMA1
3 tRNA threonylcarbamoyladenosine metabolic process GO:0070525 9.16 TP53RK LAGE3
4 tRNA threonylcarbamoyladenosine modification GO:0002949 8.96 TPRKB OSGEP
5 tRNA processing GO:0008033 8.92 TPRKB TP53RK OSGEP LAGE3

Sources for Bladder Calculus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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