MCID: BLD041
MIFTS: 34

Bladder Calculus

Categories: Nephrological diseases

Aliases & Classifications for Bladder Calculus

MalaCards integrated aliases for Bladder Calculus:

Name: Bladder Calculus 12 15 17
Urinary Bladder Calculi 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11355
MeSH 45 D001744
SNOMED-CT 69 70650003
ICD10 34 N21.0
UMLS 74 C0005683

Summaries for Bladder Calculus

MalaCards based summary : Bladder Calculus, also known as urinary bladder calculi, is related to shipyard eye and ureterocele. An important gene associated with Bladder Calculus is TPRKB (TP53RK Binding Protein), and among its related pathways/superpathways is tRNA processing. The drugs Gemcitabine and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include prostate, kidney and liver.

Related Diseases for Bladder Calculus

Diseases related to Bladder Calculus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 shipyard eye 10.2 OSGEP TP53RK
2 ureterocele 10.0
3 adenocarcinoma 10.0
4 intestinal volvulus 9.9 LAGE3 TP53RK TPRKB WDR73
5 fungal esophagitis 9.9 ATP12A ATP4A
6 bladder cancer 9.9
7 urinary tract infections, recurrent 9.9
8 paraganglioma 9.9
9 inguinal hernia 9.9
10 cystitis 9.9
11 squamous cell carcinoma 9.9
12 dermoid cyst 9.9
13 diclofenac allergy 9.9 ATP12A ATP4A
14 gastroduodenal crohn's disease 9.9 ATP12A ATP4A
15 neonatal candidiasis 9.9 ATP12A ATP4A
16 photoallergic dermatitis 9.9 ATP12A ATP4A
17 squamous papillomatosis 9.9 ATP12A ATP4A
18 toxic megacolon 9.9 ATP12A ATP4A
19 aspiration pneumonitis 9.9 ATP12A ATP4A
20 gastrointestinal neuroendocrine benign tumor 9.9 ATP12A ATP4A
21 gastric antral vascular ectasia 9.9 ATP12A ATP4A
22 granulomatous gastritis 9.9 ATP12A ATP4A
23 esophageal candidiasis 9.9 ATP12A ATP4A
24 gastric neuroendocrine neoplasm 9.9 ATP12A ATP4A
25 acute laryngitis 9.9 ATP12A ATP4A
26 laryngitis 9.9 ATP12A ATP4A
27 duodenitis 9.9 ATP12A ATP4A
28 rumination disorder 9.9 ATP12A ATP4A
29 active peptic ulcer disease 9.9 ATP12A ATP4A
30 congenital disorder of deglycosylation 9.9 ATP12A ATP4A
31 ischemic neuropathy 9.9 ATP12A ATP4A
32 bile reflux 9.9 ATP12A ATP4A
33 capillary disease 9.9 ATP12A ATP4A
34 peptic esophagitis 9.9 ATP12A ATP4A
35 dyskinesia of esophagus 9.9 ATP12A ATP4A
36 anismus 9.9 ATP12A ATP4A
37 postsurgical hypothyroidism 9.9 ATP12A ATP4A
38 lymphocytic colitis 9.8 ATP12A ATP4A
39 clostridium difficile colitis 9.8 ATP12A ATP4A
40 diarrhea 1, secretory chloride, congenital 9.8 ATP12A ATP4A
41 esophagitis, eosinophilic, 1 9.8 ATP12A ATP4A
42 microscopic colitis 9.8 ATP12A ATP4A
43 laryngeal tuberculosis 9.8 ATP12A ATP4A
44 chronic laryngitis 9.8 ATP12A ATP4A
45 eosinophilic gastritis 9.8 ATP12A ATP4A
46 esophagus adenocarcinoma 9.8 ATP12A ATP4A
47 chronic intestinal vascular insufficiency 9.8 ATP12A ATP4A
48 polyposis, skin pigmentation, alopecia, and fingernail changes 9.8 ATP12A ATP4A
49 jejunoileitis 9.8 ATP12A ATP4A
50 pancreatic steatorrhea 9.8 ATP12A ATP4A

Graphical network of the top 20 diseases related to Bladder Calculus:



Diseases related to Bladder Calculus

Symptoms & Phenotypes for Bladder Calculus

Drugs & Therapeutics for Bladder Calculus

Drugs for Bladder Calculus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 3 95058-81-4 60750
2 Antimetabolites Phase 3
3 Anti-Infective Agents Phase 3
4 Immunologic Factors Phase 3
5 Nucleic Acid Synthesis Inhibitors Phase 3
6 Immunosuppressive Agents Phase 3
7 Mitomycins Phase 3
8 Alkylating Agents Phase 3
9 Antibiotics, Antitubercular Phase 3
10 Antimetabolites, Antineoplastic Phase 3
11 Anti-Bacterial Agents Phase 3
12 Antiviral Agents Phase 3
13 Liver Extracts Not Applicable
14 Anesthetics
15 Central Nervous System Depressants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Shock Wave Lithotripsy Versus Visual Cystolitholapaxy in The Management of Patients Presenting With Calcular Acute Urinary Retention: A Randomized Controlled Trial. Unknown status NCT02594631 Phase 4
2 The Bladder Instillation Comparison Study Unknown status NCT02695771 Phase 3 Mitomycin C;Gemcitabine
3 Clipless Laparoscopic Cholecystectomy Using Harmonic Scalpel in Cirrhotic Patients a Prospective Randomized Study Completed NCT01009450 Not Applicable
4 Effects of Thoracic Epidural Anesthesia on Lower Urinary Tract Function Completed NCT00790231
5 Ultrasound-Guided Photoselective Vaporization of the Prostate Completed NCT02346500 Early Phase 1
6 Transurethral Versus Percutaneous Endoscopic Management of Bladder Stones in Boys Recruiting NCT03294239 Not Applicable
7 Electroacupuncture for Urinary Function of Patients With Chronic Urinary Retention (CUR) Secondary to Lower Motor Neuron Lesion Recruiting NCT03662906 Not Applicable
8 Evaluation of the NV-VPAC1 Prostate Cancer (PCa) Urine Diagnostic Test in Subjects With Biopsy-confirmed Prostate Cancer, Benign Prostatic Hypertrophy, or Bladder/Kidney Stones. Active, not recruiting NCT03630926

Search NIH Clinical Center for Bladder Calculus

Cochrane evidence based reviews: urinary bladder calculi

Genetic Tests for Bladder Calculus

Anatomical Context for Bladder Calculus

MalaCards organs/tissues related to Bladder Calculus:

42
Prostate, Kidney, Liver, Testes, Bone, Skin, Eye

Publications for Bladder Calculus

Articles related to Bladder Calculus:

(show top 50) (show all 65)
# Title Authors Year
1
Bladder calculus leading to acute renal failure in a girl child: a rare cause. ( 28183708 )
2017
2
Peritoneo-cutaneous fistula from spilled gall bladder calculus following laparoscopic cholecystectomy. ( 28469884 )
2017
3
Large bladder calculus masking a stone in single-system ureterocele. ( 28619970 )
2017
4
Comparative study of a new technique using nephroscope and resectoscope sheath and the percutaneous cystolithotripsy for the treatment of bladder calculus. ( 29410893 )
2017
5
Bladder Calculus at Cesarean Delivery in a Patient with Previous Cystotomy Repair. ( 29999299 )
2017
6
Concurrent Laparoscopic Hernia Repair and Cystoscopic Laser Cystolitholaxapy for Urinary Bladder Calculus Contained within a Direct Inguinal Hernia. ( 30454370 )
2017
7
Bladder calculus resulting from an intravesical translocation of intrauterine contraceptive device in a postmenopausal woman. ( 29963836 )
2016
8
The recovery of bladder epithelial hyperplasia caused by a melamine diet-induced bladder calculus in mice. ( 24355167 )
2014
9
Renal failure with a large bladder calculus related to a foreign body: a case report. ( 25356243 )
2014
10
A case-control study on the association between bladder cancer and prior bladder calculus. ( 23497224 )
2013
11
A huge bladder calculus causing acute renal failure. ( 23532429 )
2013
12
Bladder calculus formation on the tip of a migrated disused ventriculoperitoneal shunt. ( 23701800 )
2013
13
Don't get caught out! A rare case of a calcified urachal remnant mimicking a bladder calculus. ( 23705044 )
2013
14
Bladder calculus secondary to migrated intra-uterine contraceptive device. ( 24431623 )
2013
15
Fragment of pubis through the urinary bladder wall causing urinary bladder calculus. ( 21691725 )
2012
16
Squamous cell carcinoma associated with large bladder calculus. ( 22507514 )
2012
17
Vesicovaginal fistula with large bladder calculus. ( 22510189 )
2012
18
Bladder calculus presenting as recurrent urinary tract infections: a late complication of cervical cerclage placement: a case report. ( 21542538 )
2011
19
Urinary bladder calculi. ( 19345546 )
2011
20
A huge bladder calculus causing acute renal failure. ( 20033143 )
2010
21
Zinc disc implantation model of urinary bladder calculi and humane endpoints. ( 20385652 )
2010
22
End-stage renal disease with giant bladder calculus. ( 25983872 )
2008
23
Endoscopic removal of a bladder calculus via flexible sigmoidoscopy. ( 17440847 )
2007
24
Vesicocutaneous fistula caused by giant bladder calculus. ( 17457580 )
2007
25
Dermoid cyst of the urinary bladder as a differential diagnosis of bladder calculus: a case report. ( 17592652 )
2007
26
Urinary bladder calculi in a sliding vesical-inguinal-scrotal hernia diagnosed preoperatively by plain abdominal radiography. ( 18029327 )
2007
27
Surgical mesh used for an inguinal herniorrhaphy acting as a nidus for a bladder calculus. ( 16984564 )
2006
28
Bladder calculus presenting as excessive masturbation. ( 17315592 )
2006
29
Urinary bladder calculi complicating ventriculo-vesical shunt. ( 16455572 )
2005
30
Bladder calculus resulting from the migration of an intrauterine contraceptive device. ( 15540750 )
2004
31
Bladder calculus formation and urinary retention secondary to perforation of a normal bladder by a ventriculoperitoneal shunt. ( 12137842 )
2002
32
A large bladder calculus and severe vesicoureteric reflux as seen on Tc-99m MAG3 renography. ( 12394132 )
2002
33
Sonographic appearance of a bladder calculus secondary to a suture from a bladder neck suspension. ( 12418771 )
2002
34
Bladder calculus after laparoscopic colposuspension. ( 12521751 )
2002
35
Development of a large bladder calculus on sutures used for pubic bone closure following extrophy repair. ( 11550786 )
2001
36
Calcified nonfunctional paraganglioma of the urinary bladder mistaken as bladder calculus: a diagnostic pitfall. ( 10848713 )
2000
37
Massive bladder calculus as a complication of a titanium prostatic stent. ( 7850341 )
1995
38
Bladder calculus causing vesicovaginal fistula in pregnancy. ( 1933171 )
1991
39
Bladder calculus formation as a complication of the Stamey procedure. ( 2372670 )
1990
40
An unusual bladder calculus. ( 2372687 )
1990
41
Follow-up of patients treated for urinary bladder calculi. ( 2228495 )
1990
42
Bladder calculus. A rare complication of ureteric reimplantation. ( 3342309 )
1988
43
Triamterene bladder calculus. ( 3617299 )
1987
44
Assessment of the effect of androgen and estrogen on the development of prostatic adenocarcinoma and urinary bladder calculi in Nb rats. ( 3658983 )
1987
45
Case profile: large bladder calculus--postcervical cerclage. ( 3962061 )
1986
46
Calcified tumor of the urinary bladder: sonographic diagnosis and distinction from a bladder calculus. ( 3908723 )
1985
47
Giant urinary bladder calculi. ( 4064518 )
1985
48
An unusual bladder calculus. ( 6600047 )
1984
49
Radiopaque suppository simulating bladder calculus. ( 7174943 )
1982
50
Giant bladder calculus: case report. ( 6798500 )
1981

Variations for Bladder Calculus

Expression for Bladder Calculus

Search GEO for disease gene expression data for Bladder Calculus.

Pathways for Bladder Calculus

GO Terms for Bladder Calculus

Cellular components related to Bladder Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 EKC/KEOPS complex GO:0000408 8.92 LAGE3 OSGEP TP53RK TPRKB

Biological processes related to Bladder Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.43 ATP12A ATP4A
2 ATP hydrolysis coupled proton transport GO:0015991 9.4 ATP12A ATP4A
3 cellular sodium ion homeostasis GO:0006883 9.37 ATP12A ATP4A
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP12A ATP4A
5 cellular potassium ion homeostasis GO:0030007 9.26 ATP12A ATP4A
6 sodium ion export across plasma membrane GO:0036376 9.16 ATP12A ATP4A
7 tRNA threonylcarbamoyladenosine modification GO:0002949 8.96 OSGEP TPRKB
8 tRNA processing GO:0008033 8.92 LAGE3 OSGEP TP53RK TPRKB

Molecular functions related to Bladder Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Bladder Calculus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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