MCID: BLD041
MIFTS: 29

Bladder Calculus

Categories: Nephrological diseases

Aliases & Classifications for Bladder Calculus

MalaCards integrated aliases for Bladder Calculus:

Name: Bladder Calculus 12 15
Urinary Bladder Calculi 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11355
ICD10 33 N21.0
MeSH 44 D001744
SNOMED-CT 68 70650003
UMLS 73 C0005683

Summaries for Bladder Calculus

MalaCards based summary : Bladder Calculus, also known as urinary bladder calculi, is related to shipyard eye and fungal esophagitis. An important gene associated with Bladder Calculus is LAGE3 (L Antigen Family Member 3), and among its related pathways/superpathways is tRNA processing. The drugs Gemcitabine and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and skin.

Related Diseases for Bladder Calculus

Diseases related to Bladder Calculus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 shipyard eye 10.1 OSGEP TP53RK
2 fungal esophagitis 10.0 ATP12A ATP4A
3 diclofenac allergy 10.0 ATP12A ATP4A
4 gastroduodenal crohn's disease 10.0 ATP12A ATP4A
5 neonatal candidiasis 10.0 ATP12A ATP4A
6 photoallergic dermatitis 10.0 ATP12A ATP4A
7 squamous papillomatosis 10.0 ATP12A ATP4A
8 toxic megacolon 10.0 ATP12A ATP4A
9 aspiration pneumonitis 10.0 ATP12A ATP4A
10 gastrointestinal neuroendocrine benign tumor 10.0 ATP12A ATP4A
11 gastric antral vascular ectasia 10.0 ATP12A ATP4A
12 granulomatous gastritis 10.0 ATP12A ATP4A
13 esophageal candidiasis 10.0 ATP12A ATP4A
14 gastric neuroendocrine neoplasm 10.0 ATP12A ATP4A
15 acute laryngitis 10.0 ATP12A ATP4A
16 laryngitis 10.0 ATP12A ATP4A
17 duodenitis 10.0 ATP12A ATP4A
18 rumination disorder 10.0 ATP12A ATP4A
19 active peptic ulcer disease 10.0 ATP12A ATP4A
20 congenital disorder of deglycosylation 10.0 ATP12A ATP4A
21 ischemic neuropathy 10.0 ATP12A ATP4A
22 bile reflux 10.0 ATP12A ATP4A
23 ureterocele 10.0
24 capillary disease 10.0 ATP12A ATP4A
25 peptic esophagitis 10.0 ATP12A ATP4A
26 dyskinesia of esophagus 10.0 ATP12A ATP4A
27 anismus 10.0 ATP12A ATP4A
28 postsurgical hypothyroidism 10.0 ATP12A ATP4A
29 lymphocytic colitis 10.0 ATP12A ATP4A
30 esophageal atresia/tracheoesophageal fistula 10.0 ATP12A ATP4A
31 clostridium difficile colitis 10.0 ATP12A ATP4A
32 diarrhea 1, secretory chloride, congenital 10.0 ATP12A ATP4A
33 microscopic colitis 10.0 ATP12A ATP4A
34 chronic laryngitis 10.0 ATP12A ATP4A
35 eosinophilic gastritis 10.0 ATP12A ATP4A
36 esophagus adenocarcinoma 10.0 ATP12A ATP4A
37 chronic intestinal vascular insufficiency 10.0 ATP12A ATP4A
38 polyposis, skin pigmentation, alopecia, and fingernail changes 10.0 ATP12A ATP4A
39 jejunoileitis 10.0 ATP12A ATP4A
40 pancreatic steatorrhea 10.0 ATP12A ATP4A
41 esophageal varix 10.0 ATP12A ATP4A
42 duodenal disease 10.0 ATP12A ATP4A
43 gastric lymphoma 10.0 ATP12A ATP4A
44 myopathy, x-linked, with excessive autophagy 10.0 ATP12A ATP4A
45 aspiration pneumonia 10.0 ATP12A ATP4A
46 blind loop syndrome 10.0 ATP12A ATP4A
47 adenocarcinoma 10.0
48 functional gastric disease 10.0 ATP12A ATP4A
49 pneumatosis cystoides intestinalis 10.0 ATP12A ATP4A
50 trachea adenoid cystic carcinoma 10.0 PGRMC1 SMUG1

Graphical network of the top 20 diseases related to Bladder Calculus:



Diseases related to Bladder Calculus

Symptoms & Phenotypes for Bladder Calculus

Drugs & Therapeutics for Bladder Calculus

Drugs for Bladder Calculus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 3 95058-81-4 60750
2 Antiviral Agents Phase 3
3 Nucleic Acid Synthesis Inhibitors Phase 3
4 Immunosuppressive Agents Phase 3
5 Immunologic Factors Phase 3
6 Antibiotics, Antitubercular Phase 3
7 Anti-Bacterial Agents Phase 3
8 Anti-Infective Agents Phase 3
9 Alkylating Agents Phase 3
10 Mitomycins Phase 3
11 Antimetabolites Phase 3
12 Antimetabolites, Antineoplastic Phase 3
13 Liver Extracts Not Applicable
14 Anesthetics
15 Central Nervous System Depressants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Shock Wave Lithotripsy Versus Visual Cystolitholapaxy in The Management of Patients Presenting With Calcular Acute Urinary Retention: A Randomized Controlled Trial. Unknown status NCT02594631 Phase 4
2 The Bladder Instillation Comparison Study Recruiting NCT02695771 Phase 3 Mitomycin C;Gemcitabine
3 Clipless Laparoscopic Cholecystectomy Using Harmonic Scalpel in Cirrhotic Patients a Prospective Randomized Study Completed NCT01009450 Not Applicable
4 Effects of Thoracic Epidural Anesthesia on Lower Urinary Tract Function Completed NCT00790231
5 Ultrasound-Guided Photoselective Vaporization of the Prostate Completed NCT02346500 Early Phase 1
6 Transurethral Versus Percutaneous Endoscopic Management of Bladder Stones in Boys Recruiting NCT03294239 Not Applicable
7 Evaluation of the NV-VPAC1 Prostate Cancer (PCa) Urine Diagnostic Test in Subjects With Biopsy-confirmed Prostate Cancer, Benign Prostatic Hypertrophy, or Bladder/Kidney Stones. Recruiting NCT03630926
8 Electroacupuncture for Urinary Function of Patients With Chronic Urinary Retention (CUR) Secondary to Lower Motor Neuron Lesion Recruiting NCT03662906 Not Applicable

Search NIH Clinical Center for Bladder Calculus

Cochrane evidence based reviews: urinary bladder calculi

Genetic Tests for Bladder Calculus

Anatomical Context for Bladder Calculus

MalaCards organs/tissues related to Bladder Calculus:

41
Prostate, Bone, Skin, Eye, Trachea

Publications for Bladder Calculus

Articles related to Bladder Calculus:

(show top 50) (show all 64)
# Title Authors Year
1
Bladder calculus leading to acute renal failure in a girl child: a rare cause. ( 28183708 )
2017
2
Large bladder calculus masking a stone in single-system ureterocele. ( 28619970 )
2017
3
Peritoneo-cutaneous fistula from spilled gall bladder calculus following laparoscopic cholecystectomy. ( 28469884 )
2017
4
Comparative study of a new technique using nephroscope and resectoscope sheath and the percutaneous cystolithotripsy for the treatment of bladder calculus. ( 29410893 )
2017
5
Bladder Calculus at Cesarean Delivery in a Patient with Previous Cystotomy Repair. ( 29999299 )
2017
6
Concurrent Laparoscopic Hernia Repair and Cystoscopic Laser Cystolitholaxapy for Urinary Bladder Calculus Contained within a Direct Inguinal Hernia. ( 30454370 )
2017
7
Bladder calculus resulting from an intravesical translocation of intrauterine contraceptive device in a postmenopausal woman. ( 29963836 )
2016
8
Renal failure with a large bladder calculus related to a foreign body: a case report. ( 25356243 )
2014
9
The recovery of bladder epithelial hyperplasia caused by a melamine diet-induced bladder calculus in mice. ( 24355167 )
2014
10
A huge bladder calculus causing acute renal failure. ( 23532429 )
2013
11
Bladder calculus formation on the tip of a migrated disused ventriculoperitoneal shunt. ( 23701800 )
2013
12
Don't get caught out! A rare case of a calcified urachal remnant mimicking a bladder calculus. ( 23705044 )
2013
13
A case-control study on the association between bladder cancer and prior bladder calculus. ( 23497224 )
2013
14
Bladder calculus secondary to migrated intra-uterine contraceptive device. ( 24431623 )
2013
15
Fragment of pubis through the urinary bladder wall causing urinary bladder calculus. ( 21691725 )
2012
16
Vesicovaginal fistula with large bladder calculus. ( 22510189 )
2012
17
Squamous cell carcinoma associated with large bladder calculus. ( 22507514 )
2012
18
Bladder calculus presenting as recurrent urinary tract infections: a late complication of cervical cerclage placement: a case report. ( 21542538 )
2011
19
Urinary bladder calculi. ( 19345546 )
2011
20
A huge bladder calculus causing acute renal failure. ( 20033143 )
2010
21
Zinc disc implantation model of urinary bladder calculi and humane endpoints. ( 20385652 )
2010
22
End-stage renal disease with giant bladder calculus. ( 25983872 )
2008
23
Vesicocutaneous fistula caused by giant bladder calculus. ( 17457580 )
2007
24
Dermoid cyst of the urinary bladder as a differential diagnosis of bladder calculus: a case report. ( 17592652 )
2007
25
Endoscopic removal of a bladder calculus via flexible sigmoidoscopy. ( 17440847 )
2007
26
Urinary bladder calculi in a sliding vesical-inguinal-scrotal hernia diagnosed preoperatively by plain abdominal radiography. ( 18029327 )
2007
27
Surgical mesh used for an inguinal herniorrhaphy acting as a nidus for a bladder calculus. ( 16984564 )
2006
28
Bladder calculus presenting as excessive masturbation. ( 17315592 )
2006
29
Urinary bladder calculi complicating ventriculo-vesical shunt. ( 16455572 )
2005
30
Bladder calculus resulting from the migration of an intrauterine contraceptive device. ( 15540750 )
2004
31
A large bladder calculus and severe vesicoureteric reflux as seen on Tc-99m MAG3 renography. ( 12394132 )
2002
32
Sonographic appearance of a bladder calculus secondary to a suture from a bladder neck suspension. ( 12418771 )
2002
33
Bladder calculus formation and urinary retention secondary to perforation of a normal bladder by a ventriculoperitoneal shunt. ( 12137842 )
2002
34
Bladder calculus after laparoscopic colposuspension. ( 12521751 )
2002
35
Development of a large bladder calculus on sutures used for pubic bone closure following extrophy repair. ( 11550786 )
2001
36
Calcified nonfunctional paraganglioma of the urinary bladder mistaken as bladder calculus: a diagnostic pitfall. ( 10848713 )
2000
37
Massive bladder calculus as a complication of a titanium prostatic stent. ( 7850341 )
1995
38
Bladder calculus causing vesicovaginal fistula in pregnancy. ( 1933171 )
1991
39
Bladder calculus formation as a complication of the Stamey procedure. ( 2372670 )
1990
40
An unusual bladder calculus. ( 2372687 )
1990
41
Follow-up of patients treated for urinary bladder calculi. ( 2228495 )
1990
42
Bladder calculus. A rare complication of ureteric reimplantation. ( 3342309 )
1988
43
Triamterene bladder calculus. ( 3617299 )
1987
44
Assessment of the effect of androgen and estrogen on the development of prostatic adenocarcinoma and urinary bladder calculi in Nb rats. ( 3658983 )
1987
45
Case profile: large bladder calculus--postcervical cerclage. ( 3962061 )
1986
46
Calcified tumor of the urinary bladder: sonographic diagnosis and distinction from a bladder calculus. ( 3908723 )
1985
47
Giant urinary bladder calculi. ( 4064518 )
1985
48
An unusual bladder calculus. ( 6600047 )
1984
49
Radiopaque suppository simulating bladder calculus. ( 7174943 )
1982
50
Giant bladder calculus: case report. ( 6798500 )
1981

Variations for Bladder Calculus

Expression for Bladder Calculus

Search GEO for disease gene expression data for Bladder Calculus.

Pathways for Bladder Calculus

GO Terms for Bladder Calculus

Cellular components related to Bladder Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 EKC/KEOPS complex GO:0000408 8.92 LAGE3 OSGEP TP53RK TPRKB

Biological processes related to Bladder Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.46 ATP12A ATP4A
2 potassium ion import GO:0010107 9.43 ATP12A ATP4A
3 ATP hydrolysis coupled proton transport GO:0015991 9.4 ATP12A ATP4A
4 cellular sodium ion homeostasis GO:0006883 9.37 ATP12A ATP4A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP12A ATP4A
6 cellular potassium ion homeostasis GO:0030007 9.26 ATP12A ATP4A
7 sodium ion export across plasma membrane GO:0036376 9.16 ATP12A ATP4A
8 tRNA threonylcarbamoyladenosine modification GO:0002949 8.96 OSGEP TPRKB
9 tRNA processing GO:0008033 8.92 LAGE3 OSGEP TP53RK TPRKB

Molecular functions related to Bladder Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Bladder Calculus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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