MCID: BLD043
MIFTS: 27

Bladder Clear Cell Adenocarcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Bladder Clear Cell Adenocarcinoma

MalaCards integrated aliases for Bladder Clear Cell Adenocarcinoma:

Name: Bladder Clear Cell Adenocarcinoma 12 15 71
Clear Cell Adenocarcinoma of Bladder 12
Bladder Mesonephric Adenocarcinoma 12

Classifications:



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Disease Ontology 12 DOID:5306
NCIt 49 C6179
UMLS 71 C1332557

Summaries for Bladder Clear Cell Adenocarcinoma

Disease Ontology : 12 A clear cell adenocarcinoma that is located in the bladder.

MalaCards based summary : Bladder Clear Cell Adenocarcinoma, also known as clear cell adenocarcinoma of bladder, is related to nephrogenic adenoma and adenocarcinoma, and has symptoms including dysuria An important gene associated with Bladder Clear Cell Adenocarcinoma is HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M), and among its related pathways/superpathways are Primary Focal Segmental Glomerulosclerosis FSGS and Bladder cancer. Affiliated tissues include bladder, and related phenotypes are homeostasis/metabolism and cellular

Related Diseases for Bladder Clear Cell Adenocarcinoma

Diseases related to Bladder Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 312)
# Related Disease Score Top Affiliating Genes
1 nephrogenic adenoma 30.2 PAX8 PAX2 KRT7 AMACR
2 adenocarcinoma 28.5 TP53 NAPSA KRT7 KRT20 CDX2 CDKN2A
3 anal paget's disease 10.5 KRT7 CDX2
4 ovary neuroendocrine neoplasm 10.5 KRT7 CDX2
5 rete testis neoplasm 10.5 PAX8 KRT7
6 rete testis adenocarcinoma 10.5 PAX8 KRT7
7 anal gland adenocarcinoma 10.5 KRT7 CDX2
8 ureter adenocarcinoma 10.5 KRT7 CDX2
9 renal pelvis adenocarcinoma 10.5 PAX8 KRT7
10 adenosquamous colon carcinoma 10.5 KRT7 CDX2
11 nasal cavity adenocarcinoma 10.5 KRT7 CDX2
12 anus adenocarcinoma 10.5 KRT7 CDX2
13 mucinous adenofibroma 10.5 KRT7 CDX2
14 prostatic acinar adenocarcinoma 10.5 PAX8 AMACR
15 transitional papilloma 10.5 UPK3A KRT7
16 renal pelvis transitional cell carcinoma 10.5 UPK3A KRT7
17 ovarian endodermal sinus tumor 10.5 NAPSA KRT7
18 mucinous intrahepatic cholangiocarcinoma 10.5 KRT7 CDX2
19 bartholin's gland disease 10.5 KRT7 CDX2
20 rectum neuroendocrine neoplasm 10.5 KRT7 CDX2
21 subareolar duct papillomatosis 10.5 MME KRT7
22 nipple benign neoplasm 10.5 MME KRT7
23 urethra cancer 10.5 UPK3A AMACR
24 mixed epithelial stromal tumour 10.5 MME KRT7
25 vulval paget's disease 10.5 UPK3A KRT7
26 microinvasive cervical squamous cell carcinoma 10.4 WT1 KRT7
27 nephrogenic adenofibroma 10.4 WT1 KRT7
28 cervical serous adenocarcinoma 10.4 WT1 MME
29 anal canal adenocarcinoma 10.4 KRT7 CDX2
30 appendiceal neoplasm 10.4 KRT7 CDX2
31 colon leiomyosarcoma 10.4 WT1 PAX8
32 rete testis adenoma 10.4 PAX8 PAX2
33 male urethral cancer 10.4 CDKN2A AMACR
34 gastric squamous cell carcinoma 10.4 UPK3A KRT7
35 pulmonary artery leiomyosarcoma 10.4 MME KRT7
36 malignant biphasic mesothelioma 10.4 WT1 KRT7
37 balloon cell malignant melanoma 10.4 MME KRT7
38 bartholin's gland carcinoma 10.4 NAPSA KRT7 CDX2
39 pericardium cancer 10.4 WT1 KRT7
40 uterus perivascular epithelioid cell tumor 10.4 PAX8 MME KRT7
41 cervical basaloid squamous cell carcinoma 10.4 KRT7 CDKN2A
42 clear cell hidradenoma 10.4 PAX8 MME KRT7
43 ovarian primitive germ cell tumor 10.4 NAPSA KRT7 CDX2
44 clear cell papillary renal cell carcinoma 10.4 MME KRT7 AMACR
45 chromophil adenoma of the kidney 10.4 MME KRT7 AMACR
46 inverted transitional papilloma 10.4 KRT7 CDKN2A
47 mucinous tubular and spindle renal cell carcinoma 10.4 MME KRT7 AMACR
48 solid adenocarcinoma with mucin production 10.4 NAPSA KRT7
49 epithelial predominant wilms' tumor 10.3 WT1 KRT7 AMACR
50 benign mesothelioma 10.3 WT1 PAX8 KRT7

Graphical network of the top 20 diseases related to Bladder Clear Cell Adenocarcinoma:



Diseases related to Bladder Clear Cell Adenocarcinoma

Symptoms & Phenotypes for Bladder Clear Cell Adenocarcinoma

UMLS symptoms related to Bladder Clear Cell Adenocarcinoma:


dysuria

MGI Mouse Phenotypes related to Bladder Clear Cell Adenocarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 AMACR CDKN2A CDX2 CLN3 CYGB EHD1
2 cellular MP:0005384 10.11 CDKN2A CDX2 CLN3 CYGB EHD1 KRT7
3 liver/biliary system MP:0005370 9.8 AMACR CDKN2A CLN3 CYGB MME TP53
4 no phenotypic analysis MP:0003012 9.7 CDKN2A CLN3 EHD1 PAX8 SCN10A TP53
5 renal/urinary system MP:0005367 9.56 CLN3 CYGB KRT7 PAX2 PAX8 TP53
6 reproductive system MP:0005389 9.28 CDKN2A CDX2 CLN3 CYGB EHD1 PAX2

Drugs & Therapeutics for Bladder Clear Cell Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Bladder Clear Cell Adenocarcinoma

Genetic Tests for Bladder Clear Cell Adenocarcinoma

Anatomical Context for Bladder Clear Cell Adenocarcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Bladder Clear Cell Adenocarcinoma:

19
Bladder

Publications for Bladder Clear Cell Adenocarcinoma

Variations for Bladder Clear Cell Adenocarcinoma

Expression for Bladder Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Bladder Clear Cell Adenocarcinoma.

Pathways for Bladder Clear Cell Adenocarcinoma

Pathways related to Bladder Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11 WT1 PAX2 MME
2 10.66 UPK3A TP53 CDKN2A
3 10.36 PAX8 PAX2

GO Terms for Bladder Clear Cell Adenocarcinoma

Biological processes related to Bladder Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.95 WT1 TP53 PAX8 PAX2 CDX2 CDKN2A
2 kidney development GO:0001822 9.73 WT1 UPK3A PAX8 MME
3 branching involved in ureteric bud morphogenesis GO:0001658 9.67 WT1 PAX8 PAX2
4 urogenital system development GO:0001655 9.61 PAX8 PAX2
5 mesonephros development GO:0001823 9.61 PAX8 PAX2
6 mesenchymal to epithelial transition GO:0060231 9.6 WT1 PAX2
7 metanephric mesenchyme development GO:0072075 9.59 WT1 PAX2
8 cellular response to gonadotropin stimulus GO:0071371 9.58 WT1 PAX8
9 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.58 PAX8 PAX2
10 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.57 PAX8 PAX2
11 pronephros development GO:0048793 9.56 PAX8 PAX2
12 metanephric S-shaped body morphogenesis GO:0072284 9.55 WT1 PAX8
13 metanephric nephron tubule formation GO:0072289 9.54 PAX8 PAX2
14 metanephric distal convoluted tubule development GO:0072221 9.52 PAX8 PAX2
15 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.51 PAX8 PAX2
16 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.46 PAX8 PAX2
17 positive regulation of metanephric DCT cell differentiation GO:2000594 9.4 PAX8 PAX2
18 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.37 PAX8 PAX2
19 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.32 PAX8 PAX2
20 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.26 PAX8 PAX2
21 pronephric field specification GO:0039003 9.16 PAX8 PAX2
22 replicative senescence GO:0090399 9.13 TP53 MME CDKN2A
23 metanephric epithelium development GO:0072207 8.8 WT1 PAX8 PAX2

Molecular functions related to Bladder Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region sequence-specific DNA binding GO:0000976 9.26 WT1 TP53 PAX8 PAX2
2 transcription regulatory region DNA binding GO:0044212 8.92 WT1 TP53 PAX8 PAX2

Sources for Bladder Clear Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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