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MCID: BLD044
MIFTS: 49

Bladder Disease

Categories: Blood diseases, Nephrological diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Bladder Disease

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MalaCards integrated aliases for Bladder Disease:

Name: Bladder Disease 12 15 37 17
Urinary Bladder Diseases 43 71
Bladder Diseases 54 42
Urinary Bladder Disease 12

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:365
ICD9CM 34 596.9
MeSH 43 D001745
NCIt 49 C2900
SNOMED-CT 67 42643001
UMLS 71 C0005686
Sources

Summaries for Bladder Disease

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MedlinePlus : 42 The bladder is a hollow organ in your lower abdomen that stores urine. Many conditions can affect your bladder. Some common ones are Cystitis - inflammation of the bladder, often from an infection Urinary incontinence - loss of bladder control Overactive bladder - a condition in which the bladder squeezes urine out at the wrong time Interstitial cystitis - a chronic problem that causes bladder pain and frequent, urgent urination Bladder cancer Doctors diagnose bladder diseases using different tests. These include urine tests, x-rays, and an examination of the bladder wall with a scope called a cystoscope. Treatment depends on the cause of the problem. It may include medicines and, in severe cases, surgery. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Bladder Disease, also known as urinary bladder diseases, is related to gallbladder disease and bladder cancer, and has symptoms including bladder fullness sensation An important gene associated with Bladder Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are MicroRNAs in cancer and SRF and miRs in Smooth Muscle Differentiation and Proliferation. The drugs Mirabegron and Rocuronium have been mentioned in the context of this disorder. Affiliated tissues include bladder, testes and kidney.

Disease Ontology : 12 A urinary system disease that is located in the bladder.

Wikipedia : 74 Urinary bladder disease includes urinary bladder inflammation such as cystitis, bladder rupture and... more...

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Related Diseases for Bladder Disease

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Diseases related to Bladder Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 gallbladder disease 33.2 MIR199A1 MIR17 MIR145 MIR143
2 bladder cancer 30.7 TERT MIR21 MIR200A MIR193A MIR17 MIR145
3 biliary tract disease 30.5 MIR200A MIR199A1 MIR17 MIR145 H2AC18
4 in situ carcinoma 30.4 MIR193A MIR17 MIR143 MIR139 MIR106B H2AC18
5 bone inflammation disease 30.4 MIR21 MIR199A1 MIR17 H2AC18
6 pancreatic cancer 30.3 TERT MIR21 MIR200A MIR199A1 MIR17 MIR145
7 colorectal cancer 30.0 TERT MIR675 MIR21 MIR200A MIR199A1 MIR193A
8 cystitis 11.3
9 diphyllobothriasis 10.9
10 pleural cancer 10.8 MIR193A MIR17 MIR139 H2AC18
11 esophagus adenocarcinoma 10.8 MIR21 MIR193A MIR145 MIR143
12 pre-malignant neoplasm 10.7 MIR193A MIR17 MIR139 H2AC18
13 bile duct disease 10.7 MIR200A MIR199A1 MIR17 MIR145 H2AC18
14 tongue disease 10.7 MIR21 MIR199A1 MIR17 MIR145 MIR139
15 retinal vascular disease 10.7 MIR21 MIR199A1 MIR144 H2AC18
16 muscle cancer 10.7 MIR675 MIR199A1 MIR143 H2AC18
17 bile duct adenocarcinoma 10.7 MIR21 MIR199A1 MIR17 H2AC18
18 thyroid gland papillary carcinoma 10.7 MIR200A MIR199A1 MIR17 MIR144
19 autonomic nervous system neoplasm 10.7 MIR199A1 MIR193A MIR17 MIR103A1 H2AC18
20 cervix carcinoma 10.7 MIR200A MIR199A1 MIR141 MIR139 H2AC18
21 peripheral nervous system neoplasm 10.7 MIR199A1 MIR193A MIR17 MIR103A1 H2AC18
22 bone marrow cancer 10.7 MIR490 MIR21 MIR199A1 MIR17 H2AC18
23 central nervous system cancer 10.7 MIR21 MIR199A1 MIR17 MIR145 MIR144 H2AC18
24 connective tissue cancer 10.7 MIR21 MIR199A1 MIR193A MIR17 MIR139 H2AC18
25 leukocyte disease 10.7 MIR21 MIR199A1 MIR17 MIR145 MIR144 H2AC18
26 inherited metabolic disorder 10.7 MIR21 MIR199A1 MIR17 MIR144 H2AC18
27 retinal cancer 10.7 MIR675 MIR199A1 MIR17 H2AC18
28 intestinal benign neoplasm 10.7 MIR21 MIR199A1 MIR17 MIR143 MIR139 H2AC18
29 mouth disease 10.7 MIR21 MIR199A1 MIR193A MIR17 MIR145 H2AC18
30 gastrointestinal system benign neoplasm 10.7 MIR21 MIR199A1 MIR17 MIR143 MIR139 H2AC18
31 immune system disease 10.7 MIR21 MIR199A1 MIR17 MIR144 H2AC18
32 pulmonary disease, chronic obstructive 10.7 TRPV1 MIR199A1 MIR144 H2AC18 CHRM3
33 ovarian serous carcinoma 10.7 MIR21 MIR200A MIR199A1 MIR145 MIR143 MIR141
34 overnutrition 10.7 MIR21 MIR199A1 MIR17 MIR143 MIR103A1 H2AC18
35 thyroid gland disease 10.7 MIR21 MIR199A1 MIR193A MIR17 MIR144 MIR139
36 disease of mental health 10.7 MIR21 MIR199A1 MIR17 MIR144 MIR106B H2AC18
37 aortic valve disease 2 10.7 MIR21 MIR199A1 MIR17 MIR106B
38 laryngeal disease 10.7 MIR21 MIR17 MIR143 MIR139 MIR106B H2AC18
39 endocrine organ benign neoplasm 10.7 MIR21 MIR199A1 MIR17 MIR144 MIR139 MIR106B
40 diffuse large b-cell lymphoma 10.7 MIR21 MIR199A1 MIR17 MIR145 MIR143 MIR139
41 larynx cancer 10.7 TERT MIR21 MIR17 MIR143 MIR139 MIR106B
42 ovarian disease 10.7 MIR21 MIR199A1 MIR17 MIR145 H2AC18
43 rectum cancer 10.7 MIR21 MIR200A MIR193A MIR17 MIR145 MIR143
44 ocular cancer 10.7 MIR675 MIR199A1 MIR17 H2AC18
45 oral squamous cell carcinoma 10.7 MIR21 MIR199A1 MIR193A MIR17 MIR145 MIR143
46 pancreatic ductal adenocarcinoma 10.7 MIR21 MIR199A1 MIR145 MIR143 MIR141
47 endometriosis 10.7 MIR200A MIR199A1 MIR145 MIR143 MIR141
48 bone cancer 10.7 TRPV1 MIR21 MIR199A1 MIR193A
49 cardiovascular system disease 10.7 MIR21 MIR199A1 MIR17 MIR145 MIR143 H2AC18
50 malignant ovarian surface epithelial-stromal neoplasm 10.7 MIR21 MIR200A MIR199A1 MIR193A MIR17 MIR145

Comorbidity relations with Bladder Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Bladder Disease:



Diseases related to Bladder Disease
Sources

Symptoms & Phenotypes for Bladder Disease

About this section

UMLS symptoms related to Bladder Disease:


bladder fullness sensation
Sources

Drugs & Therapeutics for Bladder Disease

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Drugs for Bladder Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mirabegron Approved Phase 4 223673-61-8 9865528
2
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
3 Muscarinic Antagonists Phase 4
4 Neurotransmitter Agents Phase 4
5 Adrenergic beta-Agonists Phase 4
6 Adrenergic Agonists Phase 4
7 Solifenacin succinate Phase 4 242478-38-2
8 Adrenergic beta-3 Receptor Agonists Phase 4
9 Cholinergic Agents Phase 4
10 Cholinergic Antagonists Phase 4
11 Adrenergic Agents Phase 4
12 Neuromuscular Agents Phase 4
13 Neuromuscular Nondepolarizing Agents Phase 4
14 Neuromuscular Blocking Agents Phase 4
15 Bromides Phase 4
16
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
17
Propiverine Approved, Investigational Phase 3 60569-19-9 4942
18
tannic acid Approved Phase 3 1401-55-4
19
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
20
Perphenazine Approved Phase 3 58-39-9 4748
21
Amitriptyline Approved Phase 3 50-48-6 2160
22
Adalimumab Approved Phase 3 331731-18-1 16219006
23
Oxybutynin Approved, Investigational Phase 3 5633-20-5 4634
24
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
25
Valrubicin Approved Phase 3 56124-62-0 41744
26 Tolterodine tartrate Phase 3 124937-52-6
27 abobotulinumtoxinA Phase 3
28 Acetylcholine Release Inhibitors Phase 3
29 Botulinum Toxins, Type A Phase 3
30 Botulinum Toxins Phase 3
31 Mitogens Phase 3
32 Amitriptyline, perphenazine drug combination Phase 3
33 Tranquilizing Agents Phase 3
34 Analgesics, Non-Narcotic Phase 3
35 Psychotropic Drugs Phase 3
36 Analgesics Phase 3
37 Antipsychotic Agents Phase 3
38 Antidepressive Agents Phase 3
39 Antidepressive Agents, Tricyclic Phase 3
40 Antirheumatic Agents Phase 3
41 Anti-Inflammatory Agents Phase 3
42 Parasympatholytics Phase 3
43 Autonomic Agents Phase 3
44 Anti-Infective Agents Phase 3
45 Renal Agents Phase 3
46 Mandelic Acids Phase 3
47 Anti-Infective Agents, Urinary Phase 3
48 Topoisomerase Inhibitors Phase 3
49
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
50
Durvalumab Approved, Investigational Phase 2 1428935-60-7

Interventional clinical trials:

(show top 50) (show all 66)
# Name Status NCT ID Phase Drugs
1 Bladder Management in Patients With Multiple Sclerosis: Optimizing Practice Patterns Completed NCT01930799 Phase 4
2 The Effect of Deep Neuromuscular Blockade on Postoperative Shoulder Tip Pain After Laparoscopic Cholecystectomy Completed NCT02036827 Phase 4 Rocuronium
3 Efficacy and Safety of Mirabegron Compared With Solifenacin in Treatment of Overactive Bladder Completed NCT03558919 Phase 4 Mirabegron 25mg;Solifenacin Succinate 5 MG
4 A Double-Blind, Randomized Study of Puncturing Versus Non-Puncturing Acupuncture for the Treatment of Interstitial Cystitis Symptoms Unknown status NCT00094874 Phase 3
5 A Double-Blind, Randomized Study of the Safety and Efficacy of OnabotulinumtoxinA (OnaBoNT-A) Versus Oral Oxybutynin in Spinal Cord Injured Patients With Neurogenic Detrusor Overactivity (Protocol Number 11-09-10-04) Unknown status NCT01050114 Phase 3 onaBoNT-A;Oxybutynin ER
6 Efficacy and Tolerability of Propiverine Hydrochloride Extended Release (ER) Compared to Immediate Release (IR) in Patients With Neurogenic Detrusor Overactivity. A Randomized, Double Blind, Parallel Group, Multicenter Clinical Trial Completed NCT01530620 Phase 3 Propiverine hydrochloride ER (extended release);Propiverine hydrochloride IR (immediate release)
7 A Double-Blind, Randomized, Parallel Group, Multi-Centre Study to Evaluate the Efficacy and Safety of Mirabegron Compared to Solifenacin in Subjects With Overactive Bladder (OAB) Treated With Antimuscarinics and Dissatisfied Due to Lack of Efficacy Completed NCT01638000 Phase 3 Mirabegron;Solifenacin succinate
8 A Randomized, Double-Blind, Parallel-Group, Placebo- and Active-Controlled, Multi-center Study to Evaluate the Efficacy, Safety and Tolerability of Combinations of Solifenacin Succinate and Mirabegron Compared to Solifenacin Succinate and Mirabegron Monotherapy in the Treatment of Overactive Bladder Completed NCT01972841 Phase 3 Solifenacin succinate;Mirabegron;Placebo to match solifenacin succinate;Placebo to match mirabegron
9 A Randomized, Double-Blind, Multi-Centre Study to Evaluate the Efficacy and Safety of Adding Mirabegron to Solifenacin in Incontinent OAB Subjects Who Have Received Solifenacin for 4 Weeks and Warrant Additional Relief for Their OAB Symptoms Completed NCT01908829 Phase 3 mirabegron 25 mg;mirabegron 50 mg;solifenacin 5 mg;solifenacin 10 mg;mirabegron 25 mg matching placebo;mirabegron 50 mg matching placebo;solifenacin 5 mg matching placebo;solifenacin 10 mg matching placebo
10 A Randomized, Double-Blind, Parallel-Group, Active-Controlled, Multi-center Study to Evaluate the Long-Term Safety and Efficacy of Combination of Solifenacin Succinate With Mirabegron Compared to Solifenacin Succinate and Mirabegron Monotherapy in Subjects With Overactive Bladder Completed NCT02045862 Phase 3 Solifenacin succinate;Mirabegron;Placebo to match solifenacin;Placebo to match mirabegron
11 A Randomized Multicenter Clinical Trial to Evaluate the Efficacy of Amitriptyline for the Treatment of Painful Bladder Syndrome (PBS) in Newly Diagnosed Patients Completed NCT00124306 Phase 3 Amitriptyline
12 An Investigator Initiated, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy of Humira® (Adalimumab) For The Treatment of Interstitial Cystitis(IC) Completed NCT01295814 Phase 3 Adalimumab
13 Oxybutynin for Post-surgical Bladder Pain and Urgency Recruiting NCT03952299 Phase 3 Oxybutynin Transdermal Patch;Oral Oxybutynin
14 A Randomized Controlled Study Comparing Adjuvant Hyperthermia Treatment in Conjunction With Mitomycin C Versus BCG Immunotherapy (BCG) Adjuvant Treatment in Patients With Superficial Transitional Cell Carcinoma of the Bladder (STCCB) Terminated NCT00384891 Phase 3 Bacillus Calmette-Guérin
15 A PHASE 3B, RANDOMIZED, OPEN-LABEL, MULTI-CENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF MAINTENANCE THERAPY WITH VALRUBICIN VERSUS NO MAINTENANCE, IN SUBJECTS TREATED WITH VALRUBICIN INDUCTION FOR CARCINOMA IN SITU (CIS) OF THE BLADDER Terminated NCT01310803 Phase 3 VALSTAR - Maintenance Therapy
16 A Phase 3, Randomized, Active-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of EN3348 (MCC) as Compared With Mitomycin C in the Intravesical Treatment of Subjects With BCG Recurrent or Refractory Non-Muscle Invasive Bladder Cancer Terminated NCT01200992 Phase 3
17 A Multi-Centre, Randomised, Open-Label Active-Controlled Study Comparing Safety and Efficacy of Synergo Radiofrequency (RF)-Induced Hyperthermia-Chemotherapy With Mitomycin C (RITE) Versus Bacillus Calmette-Guérin (BCG) as First-Line Treatment of Non-Muscle Invasive Papillary Bladder Cancer (NMIBC) Withdrawn NCT02254915 Phase 3 Bacillus Calmette-Guérin
18 A Phase II Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Intravesical Alkalinized Lidocaine-Heparin for the Symptoms of Pelvic Pain and/or Urgency of Bladder Origin Completed NCT00256542 Phase 2 Alkalinized Lidocaine-Heparin
19 A Randomized, Double-Blind, Factorial, Parallel-Group, Active and Placebo-Controlled, Multicenter Dose-Ranging Study to Evaluate the Efficacy, Safety and Tolerability of Six Dose Combinations of Solifenacin Succinate and Mirabegron Compared to Mirabegron and Solifenacin Succinate Monotherapies in the Treatment of Overactive Bladder. Completed NCT01340027 Phase 2 Mirabegron;Solifenacin succinate;Placebo
20 A Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel Group, Adaptive, Combined Proof of Concept and Dose-Finding Study to Investigate Efficacy, Safety, Pharmacodynamics and Pharmacokinetics of ASP3652 in the Treatment of Female Patients With Bladder Pain Syndrome / Interstitial Cystitis Completed NCT01613586 Phase 2 ASP3652;Placebo
21 Evaluation of the Safety of Pre-TURBT Intravesical Instillation of Escalating Doses of TC-3 Gel Mixed With Mitomycin C (MMC) in Non-muscle Invasive Bladder Cancer (NMIBC) Patients Completed NCT02307487 Phase 2 120 mg MMC in 90ml gel;140 mg MMC in 90ml gel;160 mg MMC in 90ml gel;120 mg MMC in 60ml gel;140 mg MMC in 60ml gel;160 mg MMC in 60ml gel
22 A Phase 1/2a Pilot Study of Intravesical TSD-001 for Treatment of Low-Grade, Stage Ta, Non Muscle Invasive Bladder Cancer Recruiting NCT03081858 Phase 1, Phase 2 TSD-001
23 A Phase 2 Study of Check Point Inhibitor, Durvalumab (Medi4736) for Bacillus Calmette-Guérin (BCG) Refractory Urothelial Carcinoma in Situ (CIS) of the Bladder Recruiting NCT02901548 Phase 2 Durvalumab
24 A Multi-centre Randomized, Placebo-controlled Trial of Mirabegron, a New beta3-adrenergic Receptor Agonist on Left Ventricular Mass and Diastolic Function in Patients With Structural Heart Disease Enrolling by invitation NCT02599480 Phase 2 mirabegron
25 A Multi-center, Double-blind, Randomized, Placebo-controlled, Cross-over Study to Evaluate the Efficacy, Safety and Tolerability of SAF312 in Subjects With Neurogenic Detrusor Overactivity Due to Spinal Cord Lesions Who Are Inadequately Managed by Antimuscarinic Therapy Terminated NCT01598103 Phase 2 SAF312;Placebo to SAF312
26 A Randomized Controlled Trial to Evaluate the Efficacy and Tolerability of Intravesical Cocktail and Comparison With Intravesical Dimethyl Sulfoxide (DMSO) for the Treatment of Painful Bladder Syndrome Including Interstitial Cystitis (PBS/IC) Terminated NCT00317070 Phase 2 dimethyl sulfoxide;IC Cocktail
27 A Dose Escalation, Expansion Study of Vofatamab (B-701) Alone, Plus Docetaxel, or Versus Docetaxel in Subjects With Locally Advanced or Metastatic Urothelial Cell Carcinoma Who Have Relapsed After, or Are Refractory to Standard Therapy Terminated NCT02401542 Phase 1, Phase 2 Vofatamab;Docetaxel;Placebo
28 A Randomized, Double-Blind, Placebo-Controlled Study to Explore the Efficacy, Safety, and Tolerability of JNJ-42160443 in Subjects With Interstitial Cystitis/ Painful Bladder Syndrome Terminated NCT01060254 Phase 2 Placebo;JNJ-42160443
29 A Multi-Center, Open-Label Phase 1b/2 Study of a Novel FGFR3 Inhibitor (B-701) Combined With Pembrolizumab in Subjects With Locally Advanced or Metastatic Urothelial Carcinoma Who Have Progressed Following Platinum-based Chemotherapy Terminated NCT03123055 Phase 1, Phase 2 B-701;Pembrolizumab
30 A Phase I Investigation of the Safety, Tolerability and Immunogenicity of V934/V935 hTERT Vaccination in Cancer Patients With Selected Solid Tumors Completed NCT00753415 Phase 1
31 A Phase I/1b Study of Enzalutamide in Combination With Gemcitabine and Cisplatin in Bladder Cancer Completed NCT02300610 Phase 1 Enzalutamide;Cisplatin;Gemcitabine
32 A Phase 1, Open-Label, Dose-Escalation and Expansion Study of KYN-175, an Oral Aryl Hydrocarbon Receptor (AHR) Inhibitor in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma Not yet recruiting NCT04200963 Phase 1 KYN-175
33 Three-dimensional High-definition (3DHD) Laparoscopy Versus Two-dimensional High-definition (2DHD) Laparoscopy in Cholecystectomy: a Clinical Controlled Randomized Double Blinded Trial. Unknown status NCT02396927
34 Prospective Multicenter Human Randomized Controlled Evaluation of NOTES® Cholecystectomy Unknown status NCT01171027
35 A Multi Center Study to Obtain Bladder Tissue Specimens From Subjects Undergoing Transurethral Resection of Bladder Tumor (TURBT) or Other Transurethral Biopsy Procedures Completed NCT00615043
36 Bladder Endometriosis: Evaluation in MRI of the Involvement of the Posterior Inferior Wall Completed NCT03906760
37 A Prospective, Non-interventional, Registry Study of Patients Initiating a Course of DrugTherapy for Overactive Bladder (OAB) Completed NCT02386072 mirabegron;antimuscarinic medication
38 The Potential Role Of MicroRNA-155 And Telomerase Reverse Transcriptase In Diagnosis Of Non-Muscle Invasive Bladder Cancer And Their Pathological Correlation Completed NCT03591367
39 Non-Interventional Study Assessing Quality of Life, Treatment Satisfaction, Resource Utilisation, and Persistence With Treatment in Overactive Bladder (OAB) Patients Prescribed Betmiga® - A Multicenter Non-interventional Post Authorisation Study (PAS) Completed NCT02320773 Betmiga®
40 Biomechanical Assessment of Level Gait in Patient's Status Post Bladder Exstrophy Completed NCT00863070
41 Does Three-Dimensional Laparoscopy Provide Significant Advantages for Patients and Surgeons? A Randomised Controlled Trial Investigating Operating Time and Surgical Errors With 3D vs 2D Visual Systems in Laparoscopic Cholecystectomies. Completed NCT01930344
42 Evaluation of the Clinical Response of Mitomycin-C (MMC) Embedded in Hydrogel (TC-3) in Comparison to Mitomycin C in Saline, When Administered Intravesically, Pre-TURBT in Non Muscle Invasive Bladder Cancer (NMIBC) Patients. Muscle Invasive Bladder Cancer (NMIBC) Patients Completed NCT02891460
43 Heart Rate Variability in Patients With Neurogenic Detrusor Overactivity Before and After Botulinum Neurotoxin Type A Intradetrusor Injections Completed NCT01337024
44 Prospective Comparative Multicenter Study on the Medico-economical Impact of the Brindley Technique in the Management of Neurogenic Bladder in Patients With Injured Spinal Cord Completed NCT00221767
45 Development of an Evaluation Method of Elderly Condition in Patient Receiving Chemotherapy Treatment . Geriatric Oncology Protocol in Aquitaine Country. Completed NCT00210249
46 Evaluating the Effect of Pre-TURBT Intravesical Instillation of Mitomycin C (MMC) Mixed With TC-3 Gel in Patients With Non Muscle Invasive Bladder Cancer (NMIBC) Completed NCT01803295
47 Effect of Pelvic Floor Muscle Training (PFMT) in Prevention and Treatment of Female Pelvic Organ Prolapse (POP). Completed NCT00271297
48 A Randomized Trial of Single-Operator Ultrasound-Guided vs. Standard-of-Care IV Placement by Emergency Nurses Completed NCT01439113
49 Village Surveys of Morbidity Due to S. Haematobium for 1U01AI4547 Urinary Schistosomiasis-Determinants of Infection and Disease Completed NCT00138450
50 A Randomized Control Trial of a Modified Cystoscopy Method to Reduce Pain Perception Recruiting NCT03257293

Search NIH Clinical Center for Bladder Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Acetic Acid
ACETIC ACID LIQUID
ACETIC ACID,GLACIAL LIQUID
Neostigmine
Neostigmine bromide
Neostigmine Methylsulfate
Propantheline
Propantheline Bromide
tolterodine
tolterodine tartrate

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bladder Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bladder Disease:
Neo-Urinary Conduit, smooth muscle cell 3D culture for bladder diseases
Embryonic/Adult Cultured Cells Related to Bladder Disease:
Neo-Urinary Conduit PMIDs: 22136657

Cochrane evidence based reviews: urinary bladder diseases

Sources

Genetic Tests for Bladder Disease

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Sources

Anatomical Context for Bladder Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Bladder Disease:

19
Bladder

MalaCards organs/tissues related to Bladder Disease:

40
Testes, Kidney, Spinal Cord, Heart, Smooth Muscle, Prostate, Liver
Sources

Publications for Bladder Disease

About this section

Articles related to Bladder Disease:

(show top 50) (show all 626)
# Title Authors PMID Year
1
Probability of Bladder Augmentation, Diversion and Clean Intermittent Catheterization in Classic Bladder Exstrophy: A 36-Year, Multi-Institutional, Retrospective Cohort Study. 42
31526259 2019
2
Effects and safety of herbal medicines on patients with overactive bladder: A protocol for a systematic view and meta-analysis. 42
31517818 2019
3
Effectiveness of rehabilitation training combined acupuncture for the treatment of neurogenic bladder secondary to spinal cord injury. 42
31574865 2019
4
Differentiation potential of urothelium from patients with benign bladder dysfunction. 61 54
17537219 2007
5
Concentrations of specific epithelial growth factors in the urine of interstitial cystitis patients and controls. 61 54
9334654 1997
6
Screening logs from a pilot randomized controlled trial of radical cystectomy versus chemoradiation therapy for muscle-invasive bladder cancer. 61
31676280 2020
7
A homozygous missense variant in CHRM3 associated with familial urinary bladder disease. 61
31441039 2019
8
Single-Cell Transcriptomic Map of the Human and Mouse Bladders. 61
31462402 2019
9
Revealing Associations between Diagnosis Patterns and Acupoint Prescriptions Using Medical Data Extracted from Case Reports. 61
31614636 2019
10
Three-Dimensional Reconstruction of Neurovascular Network in Whole Mount Preparations and Thick-Cut Transverse Sections of Mouse Urinary Bladder. 61
31496149 2019
11
Metastatic plasmacytoid bladder cancer causing malignant priapism. 61
31266754 2019
12
Augmentation Cystoplasty of Diseased Porcine Bladders with Bi-Layer Silk Fibroin Grafts. 61
30191762 2019
13
Hypoxic changes to the urothelium as a bystander of end-stage bladder disease. 61
30862459 2019
14
NF-κB and GATA-Binding Factor 6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy. 61
30707892 2019
15
Evidence-Based Guideline on Laparoscopy in Pregnancy: Commissioned by the British Society for Gynaecological Endoscopy (BSGE) Endorsed by the Royal College of Obstetricians & Gynaecologists (RCOG). 61
31695854 2019
16
Chronic Lower Urinary Tract Signs in Cats: Current Understanding of Pathophysiology and Management. 61
30736893 2019
17
Necessity of performing voiding cystourethrography for children with unilateral multicystic dysplastic kidney. 61
30255447 2019
18
Leiomyoma of the Retzius space in a male patient: A case report and a diagnostic approach to Retzius space diseases. 61
30374998 2019
19
Spontaneous cholecystopleural fistula leading to biliothorax and sepsis in a cat. 61
30792876 2019
20
Tissue Engineering in Pediatric Bladder Reconstruction-The Road to Success. 61
30984717 2019
21
Differentiation of Urothelium from Mouse Embryonic Stem Cells in Chemically Defined Conditions. 61
31273737 2019
22
Challenges To Attenuate Ureteric Stent-Related Symptoms: Reflections On The Need To Fashion A New Dynamic Stent Design Consequent Upon A Case Report. 61
31696096 2019
23
The Impact of Individual and Parental American Indian Boarding School Attendance on Chronic Physical Health of Northern Plains Tribes. 61
30431464 2019
24
A Randomized, Double-blind, Placebo-controlled Trial of Certolizumab Pegol in Women with Refractory Interstitial Cystitis/Bladder Pain Syndrome. 61
30072210 2018
25
Normal reference values for bladder wall thickness on CT in a healthy population. 61
29392368 2018
26
Gall bladder mucoceles in Border terriers. 61
30079451 2018
27
Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis. 61
29613835 2018
28
Bladder and Ureteral Dysfunction Leading to Hydronephrosis and Hydroureteronephrosis in Adults. 61
29287975 2018
29
Characterization of voiding function and structural bladder changes in a rat model of neurogenic underactive bladder disease. 61
30105760 2018
30
Contrast-enhanced ultrasound complements two-dimensional ultrasonography in diagnosing gallbladder diseases in dogs. 61
29393556 2018
31
Underlying Chronic Disease, Medication Use, History of Running Injuries and Being a More Experienced Runner Are Independent Factors Associated With Exercise-Associated Muscle Cramping: A Cross-Sectional Study in 15778 Distance Runners. 61
28901963 2018
32
Bladder Leiomyosarcoma 25 Years after Treatment with Cyclophosphamide in Patient with History of Retinoblastoma. 61
26675030 2018
33
In Vitro Differentiation and Propagation of Urothelium from Pluripotent Stem Cell Lines. 61
28889383 2018
34
Asymptomatic solitary bladder plasmocytoma: A case report and literature review. 61
29390408 2017
35
Medical comorbidity in polycystic ovary syndrome with special focus on cardiometabolic, autoimmune, hepatic and cancer diseases: an updated review. 61
28901968 2017
36
Emergency Department Utilization in Patients With Neurogenic Bladder: Contemporary Burden and National Trends in Prevalence, Inpatient Admission, and Associated Charges, 2006-2011. 61
28755964 2017
37
Antiproliferative factor (APF) binds specifically to sites within the cytoskeleton-associated protein 4 (CKAP4) extracellular domain. 61
28893174 2017
38
Cystic duct pressures after ligation with a novel absorbable device in an ex vivo caprine cholecystectomy model. 61
28725113 2017
39
Management of Neurogenic Bladder. 61
28553689 2017
40
Long-term Outcomes of Augmentation Enterocystoplasty in Patients With End-Stage Bladder Diseases: A Single-Institute Experience Involving 102 Patients. 61
28673062 2017
41
Primary amyloidosis of the bladder; a mimicker of bladder cancer. 61
28646945 2017
42
Effect of ultrasonography surveillance in patients with liver cancer: a population-based longitudinal study. 61
28645973 2017
43
Urinary excretion of EGF and MCP-1 in children with vesicoureteral reflux. 61
28191787 2017
44
Study on the Relation between Colorectal Cancer and Gall Bladder Disease. 61
28511430 2017
45
Cigarette smoke-induced urothelial cell damage: potential role of platelet-activating factor. 61
28270596 2017
46
Is mini-laparoscopic cholecystectomy any better than the gold standard?: A comparative study. 61
27251827 2017
47
Prevalence of Lower Urinary Tract Symptoms Among Individuals Aged 50 Years and Over and Its Effect on the Quality of Life in a Semi-Rural Area of Western Turkey. 61
28120441 2017
48
Agenesis of gall bladder in laparoscopic cholecystectomy-A case report. 61
28802164 2017
49
Fiber type-specific afferent nerve activity induced by transient contractions of rat bladder smooth muscle in pathological states. 61
29267380 2017
50
A microRNA biomarker panel for the non-invasive detection of bladder cancer. 61
27863434 2016
Sources

Variations for Bladder Disease

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Expression for Bladder Disease

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Search GEO for disease gene expression data for Bladder Disease.
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Pathways for Bladder Disease

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Pathways related to Bladder Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
MicroRNAs in cancer 36
11.77 MIR21 MIR200A MIR199A1 MIR17 MIR145 MIR143
2
SRF and miRs in Smooth Muscle Differentiation and Proliferation 1
10.07 MIR199A1 MIR145
Sources

GO Terms for Bladder Disease

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Cellular components related to Bladder Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.32 MIR21 MIR199A1 MIR17 MIR144 MIR143 MIR141

Biological processes related to Bladder Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.83 MIR21 MIR199A1 MIR143 HBEGF
2 positive regulation of angiogenesis GO:0045766 9.78 TERT MIR21 MIR199A1 MIR143
3 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.69 TERT MIR21 MIR17
4 negative regulation of angiogenesis GO:0016525 9.65 MIR21 MIR193A MIR145 MIR143 MIR106B
5 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.61 MIR21 MIR17
6 negative regulation of cardiac muscle hypertrophy GO:0010614 9.61 MIR21 MIR145
7 regulation of smooth muscle contraction GO:0006940 9.6 MIR145 MIR143
8 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.59 MIR199A1 MIR17
9 negative regulation of glucose import GO:0046325 9.58 MIR143 MIR103A1
10 negative regulation of systemic arterial blood pressure GO:0003085 9.58 TRPV1 MIR17
11 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.57 MIR199A1 MIR17
12 positive regulation of metalloendopeptidase activity GO:1904685 9.56 MIR21 MIR17
13 angiotensin-activated signaling pathway GO:0038166 9.55 MIR145 MIR143
14 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.54 MIR21 MIR17
15 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.54 TERT MIR21 MIR143
16 aorta smooth muscle tissue morphogenesis GO:0060414 9.49 MIR145 MIR143
17 regulation of phenotypic switching GO:1900239 9.46 MIR145 MIR143
18 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.46 MIR21 MIR199A1 MIR145 MIR106B
19 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.43 MIR17 MIR143
20 positive regulation of vascular smooth muscle contraction GO:1904695 9.4 MIR21 CHRM3
21 gene silencing by miRNA GO:0035195 9.4 MIR675 MIR21 MIR200A MIR199A1 MIR193A MIR17
22 miRNA mediated inhibition of translation GO:0035278 9.35 MIR21 MIR17 MIR145 MIR106B MIR103A1
23 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.32 MIR145 MIR143

Molecular functions related to Bladder Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.4 MIR675 MIR21 MIR200A MIR199A1 MIR193A MIR17
Sources

Sources for Bladder Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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