MCID: BLD009
MIFTS: 38

Bladder Neck Obstruction

Categories: Nephrological diseases
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Aliases & Classifications for Bladder Neck Obstruction

MalaCards integrated aliases for Bladder Neck Obstruction:

Name: Bladder Neck Obstruction 11 14 16 71 33
Obstruction of Bladder Neck or Vesicourethral Orifice 11 33
Acquired Obstruction of Bladder Neck or Vesicourethral Orifice 33
Contracture of Bladder Neck or Sphincter 33
Strangulation of Vesicourethral Orifice 33
Stricture of Vesicourethral Orifice 33
Urinary Prostatic Valve Obstruction 33
Vesicourethral Orifice Obstruction 33
Acquired Bladder Neck Obstruction 33
Obstructed Vesicourethral Orifice 33
Urinary Bladder Neck Obstruction 43
Bno - [bladder Neck Obstruction] 33
Bladder Outflow Obstruction 33
Contracture of Bladder Neck 33
Bladder Outlet Obstruction 33
Bladder Neck Strangulation 33
Bladder Obstruction Nos 33
Bladder Neck Stricture 33
Vesical Obstruction 33

Classifications:



External Ids:

Disease Ontology 11 DOID:13948
ICD9CM 34 596.0
MeSH 43 D001748
NCIt 49 C79541
SNOMED-CT 68 197859007
ICD10 31 N32.0
ICD11 33 441939472
UMLS 71 C0005694

Summaries for Bladder Neck Obstruction

MalaCards based summary: Bladder Neck Obstruction, also known as obstruction of bladder neck or vesicourethral orifice, is related to prostatic hyperplasia, benign and urethral stricture. An important gene associated with Bladder Neck Obstruction is KLK3 (Kallikrein Related Peptidase 3). The drugs Alfuzosin and Fesoterodine have been mentioned in the context of this disorder. Affiliated tissues include prostate, smooth muscle and spinal cord.

Related Diseases for Bladder Neck Obstruction

Diseases related to Bladder Neck Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
# Related Disease Score Top Affiliating Genes
1 prostatic hyperplasia, benign 31.9 PDE5A KLK3
2 urethral stricture 30.8 PDE5A KLK3
3 impotence 30.5 TAC1 PDE5A KLK3 ACE
4 urinary tract infection 30.3 KLK3 ACE
5 prostatitis 30.3 PDE5A KLK3
6 ureterolithiasis 30.2 PDE5A KLK3
7 urinary tract obstruction 30.2 KLK3 ACE
8 interstitial cystitis 30.0 UPK1B TAC1
9 neurogenic bladder 29.8 TAC1 PDE5A KLK3 ACE
10 prostatic hypertrophy 29.8 PDE5A KLK3 ACE
11 hinman syndrome 11.3
12 urofacial syndrome 1 11.2
13 urofacial syndrome 2 11.2
14 prostate cancer 10.3
15 bladder calculus 10.3
16 hydronephrosis 10.3
17 fibrosis of extraocular muscles, congenital, 1 10.3
18 proteasome-associated autoinflammatory syndrome 1 10.3
19 bladder disease 10.3
20 muscle hypertrophy 10.2
21 prune belly syndrome 10.2
22 proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome 10.2
23 hypospadias 10.2
24 detrusor sphincter dyssynergia 10.2
25 prostatic adenoma 10.2
26 rhabdomyosarcoma 10.2
27 urethral diverticulum 10.2
28 duplication of urethra 10.2
29 rectal duplication 10.2
30 renal dysplasia 10.2
31 female stress incontinence 10.2 PDE5A KLK3
32 low compliance bladder 10.2
33 schistosomiasis 10.2
34 posterior urethral valves 10.2
35 bladder tuberculosis 10.2 TAC1 KLK3
36 congenital anomalies of kidney and urinary tract 2 10.1
37 parkinson disease, late-onset 10.1
38 renal hypodysplasia/aplasia 1 10.1
39 anus, imperforate 10.1
40 mucolipidosis ii alpha/beta 10.1
41 paine syndrome 10.1
42 prostate cancer, hereditary, 8 10.1
43 prostate cancer, hereditary, 6 10.1
44 sexual health disorder 10.1
45 inguinal hernia 10.1
46 common cold 10.1
47 henoch-schoenlein purpura 10.1
48 leiomyoma 10.1
49 constipation 10.1
50 ischemia 10.1

Comorbidity relations with Bladder Neck Obstruction via Phenotypic Disease Network (PDN): (show all 30)


Acute Cystitis Acute Kidney Failure
Balanoposthitis Bladder Cancer
Bladder Disease Chronic Kidney Disease
Cystitis Cystitis Cystica
Epididymo-Orchitis Gout
Hydronephrosis Kidney Disease
Lipoma of Spermatic Cord Nephrolithiasis, X-Linked Recessive, with Renal Failure
Neurogenic Bladder Peyronie's Disease
Prostate Calculus Prostate Cancer
Prostate Carcinoma in Situ Prostatic Hypertrophy
Prostatitis Prostatocystitis
Radiation Cystitis Spermatocele
Ureterolithiasis Urethral Calculus
Urethral Stricture Urethritis
Urinary Tract Obstruction Vesicoureteral Reflux 1

Graphical network of the top 20 diseases related to Bladder Neck Obstruction:



Diseases related to Bladder Neck Obstruction

Symptoms & Phenotypes for Bladder Neck Obstruction

Drugs & Therapeutics for Bladder Neck Obstruction

Drugs for Bladder Neck Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alfuzosin Approved, Investigational Phase 4 81403-80-7 2092
2
Fesoterodine Approved Phase 4 286930-03-8, 286930-02-7 6918558
3
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
4
Doxazosin Approved Phase 4 74191-85-8 3157
5 Adrenergic Antagonists Phase 4
6 Adrenergic alpha-Antagonists Phase 4
7 Adrenergic alpha-1 Receptor Antagonists Phase 4
8 Adrenergic Agents Phase 4
9 Neurotransmitter Agents Phase 4
10 Muscarinic Antagonists Phase 4
11 Cholinergic Antagonists Phase 4
12 Cholinergic Agents Phase 4
13
Tolterodine Tartrate Phase 4 124937-52-6
14 Antihypertensive Agents Phase 4
15
Mirabegron Approved Phase 2 223673-61-8 18319735 9865528
16
Solifenacin Succinate Phase 2 242478-38-2 216457
17 Adrenergic Agonists Phase 2
18 Adrenergic beta-Agonists Phase 2
19 Adrenergic beta-3 Receptor Agonists Phase 2
20
Ceftriaxone Approved 73384-59-5 5479530
21
Lidocaine Approved, Vet_approved 137-58-6 3676
22 Anesthetics
23 Antibiotics, Antitubercular
24 Anti-Bacterial Agents

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 The Long Term Effects of Alfuzosin(Xatral XL) in LUTS/BPH Patients: Evaluation of Voiding and Storage Function According to Bladder Outlet Obstruction Grade and Bladder Contractility Completed NCT00696761 Phase 4 Alfuzosin
2 An Open Label Study to Measure the Efficacy of Fesoterodine (Toviaz) on Continued Detrusor Overactivity in Patients That Have Undergone Treatment for Bladder Outlet Obstruction Completed NCT00605319 Phase 4 Toviaz (Fesoterodine)
3 A Randomized, Double Blind, Placebo Controlled, Four Arm (Placebo, Tolterodine ER, Tamsulosin, and Tolterodine ER Plus Tamsulosin) Study To Evaluate The Clinical Efficacy And Safety Of Tolterodine ER 4 mg In Men Who Have Frequency and Urgency, With Or Without Urinary Urge Incontinence, With Or Without Bladder Outlet Obstruction Completed NCT00147654 Phase 4 Tolterodine ER 4 mg QD;Tamsulosin 0.4 mg QD
4 Antimuscarinics as the First-line Treatment for Male With International Prostate Symptom Score (IPSS) Voiding-to-storage Subscore Rati (IPSS-V/S)≤1-- A Prospective Randomized Study Comparing With α-blockers Completed NCT01661621 Phase 4 Detrusitol 4 mg QD;Doxazosin 4 mg QD
5 The Long Term Effects of Alfuzosin (Xatral XL) in LUTS/BPH Patients: Evaluation of Symptom-specific Goal Achievement According to Symptom Improvement, Bladder Outlet Obstruction Grade and Bladder Contractility Completed NCT00836823 Phase 4 Alfuzosin
6 Uroflowmetry Parameter (Delta Q Value) as a Noninvasive Tool to Discriminate Detrusor Underactivity From Bladder Outlet Obstruction Completed NCT05359484 Phase 2, Phase 3
7 Effectiveness and Safety of Local Endoscopically-assisted Administration of Autologous Adipose-derived Regenerative Cells for Reduction of Risk of Postoperative Bladder Neck Contracture in Male Patients Unknown status NCT02869061 Phase 1, Phase 2
8 The Role Of Prophylactic Urethral Stenting With Memokath® 028SW in Patients Undergoing Prostate 125I Seed Implants For Prostate Carcinoma: A Phase I/II Study Completed NCT00252941 Phase 1, Phase 2
9 A Phase 2, Randomized, Double-Blind, Parallel Group, Placebo Controlled, Multi-Center Study to Evaluate the Safety of the Co-administration of Solifenacin Succinate With 0.4 mg Tamsulosin Hydrochloride OCAS (TOCAS) Using Urodynamics in Male Subjects With Lower Urinary Tract Symptoms (LUTS) and Bladder Outlet Obstruction (BOO) Completed NCT00507455 Phase 2 solifenacin succinate;tamsulosin hydrochloride;Placebo to solifenacin;Placebo to tamsulosin
10 A Phase 2, Randomized, Double-blind, Parallel Group, Placebo Controlled, Multi-center Study to Evaluate the Urodynamics and Safety of YM178 in Male Subjects With Lower Urinary Tract Symptoms (LUTS) and Bladder Outlet Obstruction (BOO) Completed NCT00410514 Phase 2 Mirabegron;Placebo
11 Urodynamics and Clinical Factors That Are Associated With Bladder Over-sensitivity Unknown status NCT03486639
12 Diagnosis of Bladder Outlet Obstruction Using Dynamic Urine Vibration "Holter" in Comparison to Pressure Flow Study Unknown status NCT01388348
13 Bipolar Transurethral Enucleation (BipolEP) vs Bipolar Transurethral Resection of the Prostate: A Prospective Interventional Multi-center Randomized Controlled Trial Unknown status NCT03503721
14 Short- and Medium-term Safety/Effectiveness Analysis of Low Energy Holmium Laser Enucleation of the Prostate (HoLEP) Unknown status NCT04514718
15 Bladder and Prostate Sonomorphology as a Useful Tool for Detecting Bladder Outlet Obstruction in Patients With Symptomatic Benign Prostatic Hyperplasia Unknown status NCT04352257
16 Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment Methods (UPSTREAM) for Diagnosis and Management of Bladder Outlet Obstruction in Men Unknown status NCT02193451
17 Investigating the Role of microRNAs in the Regulation of Gene Expression and Organ Remodeling During Lower Urinary Tract Dysfunction, Including Bladder Pain Syndrome/Interstitial Cystitis (BPS), and Overactive Bladder Syndrome (OAB) Completed NCT01482676
18 One-arm Feasibility and Prospective Pivotal Study to Assess the Safety and Efficacy of MediTate Temporary Implantable Nitinol Device (TIND) in Subjects Presenting Bladder Outlet Obstruction Secondary to BPH Completed NCT01436877
19 Comparison Between Invasive Pressure Flow Study and Non-invasive Penile Cuff Test Completed NCT02031653
20 An Open Prospective Multicenter Study Comparing the Urine Flow Measurements of Standard Clinic Flow Measurements vs Comercially Available Portable Digital Flow Meters and a Disposable Flow Meter in a Crossover and Randomized Order on Male BPH Subjects Completed NCT00710749
21 Prevalence Rates of Bladder Outlet Obstruction and Detrusor Underactivity and Their Clinical and Urodynamic Findings in Women With ≥Stage II Cystocele Completed NCT03613324
22 Urodynamically Age-specific Prevalence of Detrusor Underactivity and Bladder Outlet Obstruction in Female Voiding Dysfunction Without Cystocele Completed NCT04184752
23 Prevalence of Detrusor Underactivity and Bladder Outlet Obstruction in Women With Cystocele and Changes of Voiding Function After Cystocele Completed NCT04184128
24 Prevalence of Detrusor Underactivity and Bladder Outlet Obstruction in Women With and Without Symptoms of Voiding Dysfunction Completed NCT04981080
25 Fetal Cystoscopy for Severe Lower Urinary Tract Obstruction (LUTO): A Prospective Trial Recruiting NCT03281798
26 Prostatic Artery Embolization (PAE) in Patients With Advanced Prostate Cancer: A Pilot Study. Recruiting NCT03457805
27 Concomitant Renal and Urinary Bladder Allograft Transplantation Recruiting NCT04626167 Early Phase 1
28 Prospective, Open-Label, Non-Comparative, Pilot Study to Assess the Safety and Efficacy of Butterfly Medical Prostatic Retraction Device in Benign Prostatic Hyperplasia (BPH) Patients. Recruiting NCT03912558
29 Prospective, Open-Label, Non-Comparative, Study to Assess the Long Term Safety and Efficacy of Butterfly Medical Prostatic Retraction Device in Benign Prostatic Hyperplasia (BPH) Patients Who Completed 12 Months of Follow-Up Post Implantation (Continuation Study for Study BM-011-IL) Recruiting NCT05330520
30 Soractelite(Tm) Transperineal Laser Ablation for Benign Prostatic Hyperplasia With Bladder Outlet Obstruction Recruiting NCT04760483
31 Effect of Concomitant Bladder Neck Incision and Urethral Valve Ablation on Surgical Re-intervention Rate for Patients With Posterior Urethral Valve : A Randomized Controlled Trial Active, not recruiting NCT05087537
32 A Multi-centre Prospective Observational Study of the User Experience of Catheterisation and Quality of Life in Patients Prescribed GentleCath™ Air for Men Intermittent Catheter With FeelClean™ Technology Not yet recruiting NCT05470751
33 Bladder Outlet Obstruction Observation Using Dynamic Urine Vibration "Holter" With Correlation to Pressure Flow Study and Uroflowmetry. Suspended NCT01779349

Search NIH Clinical Center for Bladder Neck Obstruction

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Phenoxybenzamine
Phenoxybenzamine Hydrochloride

Cochrane evidence based reviews: urinary bladder neck obstruction

Genetic Tests for Bladder Neck Obstruction

Anatomical Context for Bladder Neck Obstruction

Organs/tissues related to Bladder Neck Obstruction:

MalaCards : Prostate, Smooth Muscle, Spinal Cord, Bone Marrow, Kidney, Dorsal Root Ganglion, Myeloid

Publications for Bladder Neck Obstruction

Articles related to Bladder Neck Obstruction:

(show top 50) (show all 3974)
# Title Authors PMID Year
1
YAP/Smad3 promotes pathological extracellular matrix microenviroment-induced bladder smooth muscle proliferation in bladder fibrosis progression. 62
36176734 2022
2
Dropped abdominal pressure at void in women. 62
35445356 2022
3
Lower urinary tract obstruction caused by fibroepithelial polyp in a newborn boy. 62
36016721 2022
4
Relationship between bladder outlet obstruction and prostatic indentation, prostatic urethral length, and bladder-prostatic urethral angle. 62
35191339 2022
5
Co-administration of sodium hydrosulfide and tadalafil modulates hypoxia and oxidative stress on bladder dysfunction in a rat model of bladder outlet obstruction. 62
36173409 2022
6
The influence of intubation on urinary flow parameters in pressure-flow study and its significance for urodynamic diagnosis. 62
35084512 2022
7
Human Urine-Derived Stem Cells Improve Partial Bladder Outlet Obstruction in Rats: Preliminary Data and microRNA-mRNA Expression Profile. 62
35230645 2022
8
A constrained mixture-micturition-growth (CMMG) model of the urinary bladder: Application to partial bladder outlet obstruction (BOO). 62
35863296 2022
9
"Glycogen deposition in the detrusor muscle of patients with bladder outlet obstruction (BOO) due to benign prostate hyperplasia (BPH); correlation with the urodynamic parameters.''. 62
36219231 2022
10
The bladder contractility and bladder outlet obstruction indices in adult men: Results of a global Delphi consensus study. 62
36273413 2022
11
Surgical outcome of male patients with chronic central nervous system disorders and voiding dysfunction due to bladder outlet obstruction. 62
35821368 2022
12
Sodium butyrate ameliorates erectile dysfunction through fibrosis in a rat model of partial bladder outlet obstruction. 62
35852413 2022
13
Inhibitory effects of vibegron, a β3-adrenoceptor agonist, on the myogenic contractile and mechanosensitive afferent activities in an obstructed rat bladder. 62
36108733 2022
14
Urodynamic risk factors of asymptomatic bacteriuria in men with non-neurogenic lower urinary tract symptoms. 62
36264427 2022
15
Urodynamic findings in female patients with nocturia: An age-matched case-control study. 62
36259768 2022
16
Robot-assisted Bladder Diverticulectomy Using a Transperitoneal Extravesical Approach. 62
36110902 2022
17
Prenatal and Early Postnatal Outcomes for Fetuses with Anatomic or Functional Renal Agenesis. 62
36198283 2022
18
Comparison of Holmium Laser Enucleation of the Prostate with Bipolar Plasmakinetic Enucleation of the Prostate: A Randomized, Prospective Controlled Trial at Midterm Follow-Up. 62
35943885 2022
19
Performance of urinary biomarkers in differentiating dysfunctional voiding in women with overactive bladder syndrome: a prospective pilot study. 62
35857158 2022
20
The The Long-term Effects of Transurethral Bladder Neck Incision in the Treatment of Female Bladder Neck Obstruction. 62
36242528 2022
21
Primary bladder neck obstruction (PBNO) in children in a resource-limited setting. 62
35800150 2022
22
Two types of detrusor underactivity in men with nonneurogenic lower urinary tract symptoms. 62
36125443 2022
23
The significance of the extent of tissue embedding for the detection of incidental prostate carcinoma on transurethral prostate resection material: the more, the better? 62
35710851 2022
24
White Matter Integrity in Men With Benign Prostatic Hyperplasia and Bladder Outlet Obstruction and Its Contribution to Lower Urinary Tract Symptoms. 62
36203254 2022
25
Acute Intravesical Capsaicin for the Study of TRPV1 in the Lower Urinary Tract: Clinical Relevance and Potential for Innovation. 62
36135835 2022
26
Spontaneous rupture of a bladder diverticulum with delayed open surgical repair. 62
35935118 2022
27
Urodynamic findings in patients with nocturia and their associations with patient characteristics. 62
35426788 2022
28
The pressure flow study investigation of pathophysiology of post-micturition dribble in male patients. 62
36125621 2022
29
Clinical audit on indications and technique of male urethral catheterization in emergency department of a tertiary care hospital. 62
36147175 2022
30
Systematic review of urinary biomarkers of female bladder outlet obstruction (fBOO). 62
36165485 2022
31
Bladder wall thickness measured by CT can predict bladder outlet obstruction in men: a retrospective cohort study. 62
36103042 2022
32
Development of a Predictive Model for the Diagnosis of Lower Urinary Tract Obstruction in Men. 62
35451862 2022
33
Use of the penile cuff test to diagnose bladder outlet obstruction: A systematic review and meta-analysis. 62
35716000 2022
34
Do we have enough evidence to propose a urinary biomarker of bladder ischemia? A systematic review and meta-analysis. 62
35438247 2022
35
A Rare Case of Female Bladder Outlet Obstruction: Severe Introital Stenosis. 62
36210671 2022
36
Urethral duplication with bilateral megaureter and bladder outlet obstruction: unusual case managed by PADUA technique. 62
35792899 2022
37
Exosomes from human urine-derived stem cells carry NRF1 to alleviate bladder fibrosis via regulating miR-301b-3p/TGFβR1 pathway. 62
35933548 2022
38
[Home uroflowmetry technics and clinical relevance: A narrative review]. 62
35961806 2022
39
ATOMS (Adjustable Trans-Obturator Male System) in Patients with Post-Prostatectomy Incontinence and Previously Treated Urethral Stricture or Bladder Neck Contracture. 62
36013121 2022
40
Technique, outcome and changes in prostate dimensions in patients with urinary retention managed by aquablation. 62
35622268 2022
41
Green light laser enucleation of the prostate with early apical release is safe and effective: single center experience and revision of the literature. 62
33781016 2022
42
Detection rate and variables associated with incidental prostate cancer by holmium laser enucleation of the prostate. 62
35584916 2022
43
NIRS: Past, Present, and Future in Functional Urology. 62
35971538 2022
44
Outcomes of a complementary and alternative medicine based on vitamins, herbal products, and amino acid as a first line treatment in idiopathic overactive bladder syndrome in men and women without bladder outlet obstruction. 62
35176933 2022
45
Outcomes of bladder neck botulinum toxin injection for female primary bladder neck obstruction-does subjective improvement correlate with an objective assessment? 62
35939098 2022
46
Thulium laser vapo-enucleation treatment for prostates >100 cc following urinary retention. 62
34313521 2022
47
Correlation between prostate volume measured by ultrasound and symptoms severity score in patients with benign prostatic hypertrophy in Southeastern Nigeria. 62
35975376 2022
48
Long-term outcomes of bipolar transurethral enucleation and resection of the prostate on patients with benign prostatic obstruction: a 10-year follow-up. 62
35938386 2022
49
Concomitant anterior urethral valve, distal urethral diverticulum and posterior urethral valve with five-year follow up; A case report and literature review. 62
35311025 2022
50
Experience with the use of mohan's valvotome for posterior urethral valve ablation at a centre in North-Eastern Nigeria. 62
35775514 2022

Variations for Bladder Neck Obstruction

Expression for Bladder Neck Obstruction

Search GEO for disease gene expression data for Bladder Neck Obstruction.

Pathways for Bladder Neck Obstruction

GO Terms for Bladder Neck Obstruction

Sources for Bladder Neck Obstruction

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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