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MCID: BLD009
MIFTS: 38

Bladder Neck Obstruction

Categories: Nephrological diseases
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Aliases & Classifications for Bladder Neck Obstruction

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MalaCards integrated aliases for Bladder Neck Obstruction:

Name: Bladder Neck Obstruction 11 14 16 71 33
Obstruction of Bladder Neck or Vesicourethral Orifice 11 33
Acquired Obstruction of Bladder Neck or Vesicourethral Orifice 33
Contracture of Bladder Neck or Sphincter 33
Strangulation of Vesicourethral Orifice 33
Stricture of Vesicourethral Orifice 33
Urinary Prostatic Valve Obstruction 33
Vesicourethral Orifice Obstruction 33
Acquired Bladder Neck Obstruction 33
Obstructed Vesicourethral Orifice 33
Urinary Bladder Neck Obstruction 43
Bno - [bladder Neck Obstruction] 33
Bladder Outflow Obstruction 33
Contracture of Bladder Neck 33
Bladder Outlet Obstruction 33
Bladder Neck Strangulation 33
Bladder Obstruction Nos 33
Bladder Neck Stricture 33
Vesical Obstruction 33

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


External Ids:

Disease Ontology 11 DOID:13948
ICD9CM 34 596.0
MeSH 43 D001748
NCIt 49 C79541
SNOMED-CT 68 197859007
ICD10 31 N32.0
ICD11 33 441939472
UMLS 71 C0005694
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Summaries for Bladder Neck Obstruction

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MalaCards based summary: Bladder Neck Obstruction, also known as obstruction of bladder neck or vesicourethral orifice, is related to prostatic hyperplasia, benign and urethral stricture. An important gene associated with Bladder Neck Obstruction is KLK3 (Kallikrein Related Peptidase 3). The drugs Alfuzosin and Tamsulosin have been mentioned in the context of this disorder. Affiliated tissues include prostate, smooth muscle and spinal cord.
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Related Diseases for Bladder Neck Obstruction

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Diseases related to Bladder Neck Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 prostatic hyperplasia, benign 31.9 PDE5A KLK3
2 urethral stricture 30.8 PDE5A KLK3
3 impotence 30.5 TAC1 PDE5A KLK3 ACE
4 urinary tract infection 30.4 KLK3 ACE
5 prostatitis 30.3 PDE5A KLK3
6 urinary tract obstruction 30.3 KLK3 ACE
7 ureterolithiasis 30.3 PDE5A KLK3
8 interstitial cystitis 30.0 UPK1B TAC1
9 neurogenic bladder 29.9 TAC1 PDE5A KLK3 ACE
10 prostatic hypertrophy 29.8 PDE5A KLK3 ACE
11 hinman syndrome 11.3
12 urofacial syndrome 1 11.2
13 urofacial syndrome 2 11.2
14 muscle hypertrophy 10.7
15 overactive bladder syndrome 10.4
16 prostate cancer 10.3
17 bladder calculus 10.3
18 hydronephrosis 10.3
19 bladder disease 10.3
20 renal dysplasia 10.3
21 prune belly syndrome 10.2
22 proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome 10.2
23 hypospadias 10.2
24 detrusor sphincter dyssynergia 10.2
25 prostatic adenoma 10.2
26 rhabdomyosarcoma 10.2
27 urethral diverticulum 10.2
28 duplication of urethra 10.2
29 rectal duplication 10.2
30 female stress incontinence 10.2 PDE5A KLK3
31 schistosomiasis 10.2
32 posterior urethral valves 10.2
33 bladder tuberculosis 10.2 TAC1 KLK3
34 congenital anomalies of kidney and urinary tract 2 10.1
35 parkinson disease, late-onset 10.1
36 renal hypodysplasia/aplasia 1 10.1
37 anus, imperforate 10.1
38 hymen, imperforate 10.1
39 mucolipidosis ii alpha/beta 10.1
40 paine syndrome 10.1
41 prostate cancer, hereditary, 8 10.1
42 prostate cancer, hereditary, 6 10.1
43 sexual health disorder 10.1
44 inguinal hernia 10.1
45 henoch-schoenlein purpura 10.1
46 leiomyoma 10.1
47 ischemia 10.1
48 hypokalemia 10.1
49 cystitis cystica 10.1
50 48,xyyy 10.1

Comorbidity relations with Bladder Neck Obstruction via Phenotypic Disease Network (PDN): (show all 30)


Acute Cystitis Acute Kidney Failure
Balanoposthitis Bladder Cancer
Bladder Disease Chronic Kidney Disease
Cystitis Cystitis Cystica
Epididymo-Orchitis Gout
Hydronephrosis Kidney Disease
Lipoma of Spermatic Cord Nephrolithiasis, X-Linked Recessive, with Renal Failure
Neurogenic Bladder Peyronie's Disease
Prostate Calculus Prostate Cancer
Prostate Carcinoma in Situ Prostatic Hypertrophy
Prostatitis Prostatocystitis
Radiation Cystitis Spermatocele
Ureterolithiasis Urethral Calculus
Urethral Stricture Urethritis
Urinary Tract Obstruction Vesicoureteral Reflux 1

Graphical network of the top 20 diseases related to Bladder Neck Obstruction:



Diseases related to Bladder Neck Obstruction
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Symptoms & Phenotypes for Bladder Neck Obstruction

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Drugs & Therapeutics for Bladder Neck Obstruction

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Drugs for Bladder Neck Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alfuzosin Approved, Investigational Phase 4 81403-80-7 2092
2
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
3
Fesoterodine Approved Phase 4 286930-03-8, 286930-02-7 6918558
4
Doxazosin Approved Phase 4 74191-85-8 3157
5 Neurotransmitter Agents Phase 4
6 Adrenergic Antagonists Phase 4
7 Adrenergic alpha-Antagonists Phase 4
8 Adrenergic alpha-1 Receptor Antagonists Phase 4
9 Adrenergic Agents Phase 4
10 Muscarinic Antagonists Phase 4
11 Cholinergic Antagonists Phase 4
12 Cholinergic Agents Phase 4
13
Tolterodine Tartrate Phase 4 124937-52-6
14 Antihypertensive Agents Phase 4
15
Mirabegron Approved Phase 2 223673-61-8 18319735 9865528
16
Solifenacin Succinate Phase 2 242478-38-2 216457
17 Adrenergic beta-Agonists Phase 2
18 Adrenergic beta-3 Receptor Agonists Phase 2
19 Adrenergic Agonists Phase 2
20
Ceftriaxone Approved 73384-59-5 5479530
21
Lidocaine Approved, Vet_approved 137-58-6 3676
22 Anesthetics
23 Anti-Bacterial Agents
24 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 The Long Term Effects of Alfuzosin(Xatral XL) in LUTS/BPH Patients: Evaluation of Voiding and Storage Function According to Bladder Outlet Obstruction Grade and Bladder Contractility Completed NCT00696761 Phase 4 Alfuzosin
2 A Randomized, Double Blind, Placebo Controlled, Four Arm (Placebo, Tolterodine ER, Tamsulosin, and Tolterodine ER Plus Tamsulosin) Study To Evaluate The Clinical Efficacy And Safety Of Tolterodine ER 4 mg In Men Who Have Frequency and Urgency, With Or Without Urinary Urge Incontinence, With Or Without Bladder Outlet Obstruction Completed NCT00147654 Phase 4 Tolterodine ER 4 mg QD;Tamsulosin 0.4 mg QD
3 An Open Label Study to Measure the Efficacy of Fesoterodine (Toviaz) on Continued Detrusor Overactivity in Patients That Have Undergone Treatment for Bladder Outlet Obstruction Completed NCT00605319 Phase 4 Toviaz (Fesoterodine)
4 Antimuscarinics as the First-line Treatment for Male With International Prostate Symptom Score (IPSS) Voiding-to-storage Subscore Rati (IPSS-V/S)≤1-- A Prospective Randomized Study Comparing With α-blockers Completed NCT01661621 Phase 4 Detrusitol 4 mg QD;Doxazosin 4 mg QD
5 The Long Term Effects of Alfuzosin (Xatral XL) in LUTS/BPH Patients: Evaluation of Symptom-specific Goal Achievement According to Symptom Improvement, Bladder Outlet Obstruction Grade and Bladder Contractility Completed NCT00836823 Phase 4 Alfuzosin
6 Anatomical Endoscopic Enucleation of the Prostate for Treatment of Bladder Outlet Obstruction in Patients With Low-risk Prostate Cancer on Surveillance Protocol, Prospective Assessment of Functional and Oncological Outcome Active, not recruiting NCT05631080 Phase 4
7 Uroflowmetry Parameter (Delta Q Value) as a Noninvasive Tool to Discriminate Detrusor Underactivity From Bladder Outlet Obstruction Completed NCT05359484 Phase 2, Phase 3
8 Effectiveness and Safety of Local Endoscopically-assisted Administration of Autologous Adipose-derived Regenerative Cells for Reduction of Risk of Postoperative Bladder Neck Contracture in Male Patients Unknown status NCT02869061 Phase 1, Phase 2
9 A Phase 2, Randomized, Double-Blind, Parallel Group, Placebo Controlled, Multi-Center Study to Evaluate the Safety of the Co-administration of Solifenacin Succinate With 0.4 mg Tamsulosin Hydrochloride OCAS (TOCAS) Using Urodynamics in Male Subjects With Lower Urinary Tract Symptoms (LUTS) and Bladder Outlet Obstruction (BOO) Completed NCT00507455 Phase 2 solifenacin succinate;tamsulosin hydrochloride;Placebo to solifenacin;Placebo to tamsulosin
10 A Phase 2, Randomized, Double-blind, Parallel Group, Placebo Controlled, Multi-center Study to Evaluate the Urodynamics and Safety of YM178 in Male Subjects With Lower Urinary Tract Symptoms (LUTS) and Bladder Outlet Obstruction (BOO) Completed NCT00410514 Phase 2 Mirabegron;Placebo
11 The Role Of Prophylactic Urethral Stenting With Memokath® 028SW in Patients Undergoing Prostate 125I Seed Implants For Prostate Carcinoma: A Phase I/II Study Completed NCT00252941 Phase 1, Phase 2
12 Diagnosis of Bladder Outlet Obstruction Using Dynamic Urine Vibration "Holter" in Comparison to Pressure Flow Study Unknown status NCT01388348
13 Bipolar Transurethral Enucleation (BipolEP) vs Bipolar Transurethral Resection of the Prostate: A Prospective Interventional Multi-center Randomized Controlled Trial Unknown status NCT03503721
14 Short- and Medium-term Safety/Effectiveness Analysis of Low Energy Holmium Laser Enucleation of the Prostate (HoLEP) Unknown status NCT04514718
15 Urodynamics and Clinical Factors That Are Associated With Bladder Over-sensitivity Unknown status NCT03486639
16 Bladder and Prostate Sonomorphology as a Useful Tool for Detecting Bladder Outlet Obstruction in Patients With Symptomatic Benign Prostatic Hyperplasia Unknown status NCT04352257
17 Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment Methods (UPSTREAM) for Diagnosis and Management of Bladder Outlet Obstruction in Men Unknown status NCT02193451
18 Investigating the Role of microRNAs in the Regulation of Gene Expression and Organ Remodeling During Lower Urinary Tract Dysfunction, Including Bladder Pain Syndrome/Interstitial Cystitis (BPS), and Overactive Bladder Syndrome (OAB) Completed NCT01482676
19 One-arm Feasibility and Prospective Pivotal Study to Assess the Safety and Efficacy of MediTate Temporary Implantable Nitinol Device (TIND) in Subjects Presenting Bladder Outlet Obstruction Secondary to BPH Completed NCT01436877
20 Urodynamically Age-specific Prevalence of Detrusor Underactivity and Bladder Outlet Obstruction in Female Voiding Dysfunction Without Cystocele Completed NCT04184752
21 An Open Prospective Multicenter Study Comparing the Urine Flow Measurements of Standard Clinic Flow Measurements vs Comercially Available Portable Digital Flow Meters and a Disposable Flow Meter in a Crossover and Randomized Order on Male BPH Subjects Completed NCT00710749
22 Comparison Between Invasive Pressure Flow Study and Non-invasive Penile Cuff Test Completed NCT02031653
23 Prevalence of Detrusor Underactivity and Bladder Outlet Obstruction in Women With Cystocele and Changes of Voiding Function After Cystocele Completed NCT04184128
24 Prevalence Rates of Bladder Outlet Obstruction and Detrusor Underactivity and Their Clinical and Urodynamic Findings in Women With ≥Stage II Cystocele Completed NCT03613324
25 Prevalence of Detrusor Underactivity and Bladder Outlet Obstruction in Women With and Without Symptoms of Voiding Dysfunction Completed NCT04981080
26 Fetal Cystoscopy for Severe Lower Urinary Tract Obstruction (LUTO): A Prospective Trial Recruiting NCT03281798
27 Concomitant Renal and Urinary Bladder Allograft Transplantation Recruiting NCT04626167 Early Phase 1
28 Prostatic Artery Embolization (PAE) in Patients With Advanced Prostate Cancer: A Pilot Study. Recruiting NCT03457805
29 Prospective, Open-Label, Non-Comparative, Pilot Study to Assess the Safety and Efficacy of Butterfly Medical Prostatic Retraction Device in Benign Prostatic Hyperplasia (BPH) Patients. Recruiting NCT03912558
30 Prospective, Open-Label, Non-Comparative, Study to Assess the Long Term Safety and Efficacy of Butterfly Medical Prostatic Retraction Device in Benign Prostatic Hyperplasia (BPH) Patients Who Completed 12 Months of Follow-Up Post Implantation (Continuation Study for Study BM-011-IL) Recruiting NCT05330520
31 Soractelite(Tm) Transperineal Laser Ablation for Benign Prostatic Hyperplasia With Bladder Outlet Obstruction Recruiting NCT04760483
32 Effect of Concomitant Bladder Neck Incision and Urethral Valve Ablation on Surgical Re-intervention Rate for Patients With Posterior Urethral Valve : A Randomized Controlled Trial Active, not recruiting NCT05087537
33 A Multi-centre Prospective Observational Study of the User Experience of Catheterisation and Quality of Life in Patients Prescribed GentleCath™ Air for Men Intermittent Catheter With FeelClean™ Technology Not yet recruiting NCT05470751
34 Bladder Outlet Obstruction Observation Using Dynamic Urine Vibration "Holter" With Correlation to Pressure Flow Study and Uroflowmetry. Suspended NCT01779349

Search NIH Clinical Center for Bladder Neck Obstruction

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Phenoxybenzamine
Phenoxybenzamine Hydrochloride

Cochrane evidence based reviews: urinary bladder neck obstruction

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Genetic Tests for Bladder Neck Obstruction

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Anatomical Context for Bladder Neck Obstruction

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Organs/tissues related to Bladder Neck Obstruction:

MalaCards : Prostate, Smooth Muscle, Spinal Cord, Bone Marrow, Kidney, Dorsal Root Ganglion, Myeloid
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Publications for Bladder Neck Obstruction

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Articles related to Bladder Neck Obstruction:

(show top 50) (show all 3991)
# Title Authors PMID Year
1
Biomarkers in Urethral Stricture Disease and Benign Lower Urinary Tract Disease. 62
36424081 2023
2
Comparison of Holmium Laser Enucleation of the Prostate with Bipolar Plasmakinetic Enucleation of the Prostate: A Randomized, Prospective Controlled Trial at Midterm Follow-Up. 62
35943885 2022
3
"Glycogen deposition in the detrusor muscle of patients with bladder outlet obstruction (BOO) due to benign prostate hyperplasia (BPH); correlation with the urodynamic parameters.''. 62
36219231 2022
4
Peroxinitrite and Malondialdehyde as Biomarkers for Overactive Bladder. 62
36474380 2022
5
[Home uroflowmetry technics and clinical relevance: A narrative review]. 62
35961806 2022
6
Predicting post-radiation genitourinary hospital admissions in patients with localised prostate cancer. 62
36357601 2022
7
Urodynamic risk factors of asymptomatic bacteriuria in men with non-neurogenic lower urinary tract symptoms. 62
36264427 2022
8
YAP/Smad3 promotes pathological extracellular matrix microenviroment-induced bladder smooth muscle proliferation in bladder fibrosis progression. 62
36176734 2022
9
Lower urinary tract obstruction caused by fibroepithelial polyp in a newborn boy. 62
36016721 2022
10
The influence of intubation on urinary flow parameters in pressure-flow study and its significance for urodynamic diagnosis. 62
35084512 2022
11
Dropped abdominal pressure at void in women. 62
35445356 2022
12
Continent ileocaecocystoplasty bladder augmentation following a failed appendicovesicostomy on pediatric bladder neck stricture due to pelvic fracture urethral injury: A case report. 62
36457952 2022
13
Oncological and urinary outcomes following low-dose-rate brachytherapy with a median follow-up of 11.8 years. 62
35791775 2022
14
Photoselective sharp enucleation of the prostate with a front-firing 532-nm laser versus photoselective vaporization of the prostate in the treatment of benign prostatic hyperplasia: a randomised controlled trial with 1-year followup results. 62
36344969 2022
15
Co-administration of sodium hydrosulfide and tadalafil modulates hypoxia and oxidative stress on bladder dysfunction in a rat model of bladder outlet obstruction. 62
36173409 2022
16
Prevalence and Predictors of Bladder Outlet Obstruction in Women With Chronic Urinary Symptoms and a History of Urethral Sling Surgery. 62
36395440 2022
17
Detrusor Underactivity in Men with Bladder Outlet Obstruction. 62
36428522 2022
18
CircRNA/miRNA/mRNA axis participates in the progression of partial bladder outlet obstruction. 62
36434693 2022
19
Relationship between bladder outlet obstruction and prostatic indentation, prostatic urethral length, and bladder-prostatic urethral angle. 62
35191339 2022
20
A Scoping Review of the Management of Benign Prostate Hyperplasia in Africa. 62
36349068 2022
21
Transurethral water vapor ablation of the prostate with the Rezūm system: Urodynamic findings. 62
36335610 2022
22
Endoscopic Enucleation of Prostate Could Increase Testosterone Levels in Hypotestosteronemic Patients with Bladder Outlet Obstruction. 62
36431285 2022
23
Performance of urinary biomarkers in differentiating dysfunctional voiding in women with overactive bladder syndrome: a prospective pilot study. 62
35857158 2022
24
Human Urine-Derived Stem Cells Improve Partial Bladder Outlet Obstruction in Rats: Preliminary Data and microRNA-mRNA Expression Profile. 62
35230645 2022
25
Sodium butyrate ameliorates erectile dysfunction through fibrosis in a rat model of partial bladder outlet obstruction. 62
35852413 2022
26
Surgical outcome of male patients with chronic central nervous system disorders and voiding dysfunction due to bladder outlet obstruction. 62
35821368 2022
27
A constrained mixture-micturition-growth (CMMG) model of the urinary bladder: Application to partial bladder outlet obstruction (BOO). 62
35863296 2022
28
Bladder Oversensitivity Is Associated with Bladder Outlet Obstruction in Men. 62
36294814 2022
29
The bladder contractility and bladder outlet obstruction indices in adult men: Results of a global Delphi consensus study. 62
36273413 2022
30
The Long-term Effects of Transurethral Bladder Neck Incision in the Treatment of Female Bladder Neck Obstruction. 62
36242528 2022
31
Inverted-Y Ureteric Duplication With Paraureteric Diverticulum Presenting With Bladder Outlet Obstruction in an Infant- A Diagnostic Dilemma. 62
36283504 2022
32
Robot-assisted Bladder Diverticulectomy Using a Transperitoneal Extravesical Approach. 62
36110902 2022
33
Prenatal and Early Postnatal Outcomes for Fetuses with Anatomic or Functional Renal Agenesis. 62
36198283 2022
34
Risk factors for postoperative adverse outcomes and secondary surgery in pediatric patients with unilateral ectopic ureterocele associated with the duplex system. 62
36336622 2022
35
Urodynamic findings in female patients with nocturia: An age-matched case-control study. 62
36259768 2022
36
Inhibitory effects of vibegron, a β3-adrenoceptor agonist, on the myogenic contractile and mechanosensitive afferent activities in an obstructed rat bladder. 62
36108733 2022
37
Two types of detrusor underactivity in men with nonneurogenic lower urinary tract symptoms. 62
36125443 2022
38
Acute Intravesical Capsaicin for the Study of TRPV1 in the Lower Urinary Tract: Clinical Relevance and Potential for Innovation. 62
36135835 2022
39
Prostate Surgery for Men with Lower Urinary Tract Symptoms: Do We Need Urodynamics to Find the Right Candidates? Exploratory Findings from the UPSTREAM Trial. 62
34922898 2022
40
Urodynamic findings in patients with nocturia and their associations with patient characteristics. 62
35426788 2022
41
The pressure flow study investigation of pathophysiology of post-micturition dribble in male patients. 62
36125621 2022
42
Clinical audit on indications and technique of male urethral catheterization in emergency department of a tertiary care hospital. 62
36147175 2022
43
The Prevalence of Nocturnal Polyuria in the United States: Results from the Epidemiology of Nocturnal Polyuria Study. 62
35039242 2022
44
Do we have enough evidence to propose a urinary biomarker of bladder ischemia? A systematic review and meta-analysis. 62
35438247 2022
45
Development of a Predictive Model for the Diagnosis of Lower Urinary Tract Obstruction in Men. 62
35451862 2022
46
White Matter Integrity in Men With Benign Prostatic Hyperplasia and Bladder Outlet Obstruction and Its Contribution to Lower Urinary Tract Symptoms. 62
36203254 2022
47
Spontaneous rupture of a bladder diverticulum with delayed open surgical repair. 62
35935118 2022
48
Benefits and Harms of Conservative, Pharmacological, and Surgical Management Options for Women with Bladder Outlet Obstruction: A Systematic Review from the European Association of Urology Non-neurogenic Female LUTS Guidelines Panel. 62
34702649 2022
49
The significance of the extent of tissue embedding for the detection of incidental prostate carcinoma on transurethral prostate resection material: the more, the better? 62
35710851 2022
50
Primary bladder neck obstruction (PBNO) in children in a resource-limited setting. 62
35800150 2022
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Variations for Bladder Neck Obstruction

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Expression for Bladder Neck Obstruction

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Search GEO for disease gene expression data for Bladder Neck Obstruction.
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Pathways for Bladder Neck Obstruction

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GO Terms for Bladder Neck Obstruction

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Sources for Bladder Neck Obstruction

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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