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MCID: BLD009
MIFTS: 33

Bladder Neck Obstruction

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Bladder Neck Obstruction

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MalaCards integrated aliases for Bladder Neck Obstruction:

Name: Bladder Neck Obstruction 12 15 17 70
Obstruction of Bladder Neck or Vesicourethral Orifice 12
Urinary Bladder Neck Obstruction 44

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:13948
ICD9CM 34 596.0
MeSH 44 D001748
NCIt 50 C79541
SNOMED-CT 67 197859007
ICD10 32 N32.0
UMLS 70 C0005694
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Summaries for Bladder Neck Obstruction

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MalaCards based summary : Bladder Neck Obstruction, also known as obstruction of bladder neck or vesicourethral orifice, is related to urethral stricture and prostatitis. An important gene associated with Bladder Neck Obstruction is PDE5A (Phosphodiesterase 5A). The drugs Tamsulosin and Fesoterodine have been mentioned in the context of this disorder. Affiliated tissues include prostate, spinal cord and smooth muscle.

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Related Diseases for Bladder Neck Obstruction

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Diseases related to Bladder Neck Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 urethral stricture 30.6 PDE5A KLK3
2 prostatitis 30.3 PDE5A KLK3
3 neurogenic bladder 30.2 TAC1 PDE5A KLK3
4 acute cystitis 30.1 KLK3 ACE
5 urinary tract obstruction 29.8 KLK3 ACE
6 vesicoureteral reflux 1 29.6 UPK1B ACE
7 hydronephrosis 10.3
8 female stress incontinence 10.2 PDE5A KLK3
9 prostatic hyperplasia, benign 10.2 PDE5A KLK3
10 urinary tract infection 10.2
11 low compliance bladder 10.2
12 vasculogenic impotence 10.1 PDE5A ACE
13 pulmonary valve insufficiency 10.1 PDE5A ACE
14 diabetes insipidus, nephrogenic, autosomal 10.1
15 schistosoma mansoni infection, susceptibility/ 10.1
16 ureterocele 10.1
17 prostatic hypertrophy 10.1
18 schistosomiasis 10.1
19 kidney disease 10.1
20 diabetes insipidus 10.1
21 posterior urethral valves 10.1
22 pure autonomic failure 10.1 PDE5A ACE
23 raynaud disease 10.1 PDE5A ACE
24 chronic pulmonary heart disease 10.1 PDE5A ACE
25 urethral syndrome 10.1 TAC1 KLK3
26 tricuspid valve disease 10.1 PDE5A ACE
27 hereditary angioedema with normal c1inh 10.1 KLK3 ACE
28 tricuspid valve insufficiency 10.1 PDE5A ACE
29 intracranial vasospasm 10.1 TAC1 ACE
30 acute apical periodontitis 10.1 TAC1 ACE
31 diastolic heart failure 10.0 PDE5A ACE
32 aspiration pneumonia 10.0 TAC1 ACE
33 autonomic nervous system disease 10.0 TAC1 ACE
34 complex regional pain syndrome 10.0 TAC1 ACE
35 limited scleroderma 10.0 PDE5A ACE
36 nonarteritic anterior ischemic optic neuropathy 10.0 PDE5A ACE
37 carpal tunnel syndrome 10.0 TAC1 ACE
38 bladder cancer 9.9
39 ehlers-danlos syndrome, classic type, 1 9.9
40 pelvic organ prolapse 9.9
41 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
42 lower urinary tract obstruction, congenital 9.9
43 rapidly involuting congenital hemangioma 9.9
44 oligohydramnios 9.9
45 ehlers-danlos syndrome 9.9
46 urethritis 9.9
47 cystitis 9.9
48 transitional cell carcinoma 9.9
49 prostatic adenoma 9.9
50 uremia 9.9

Comorbidity relations with Bladder Neck Obstruction via Phenotypic Disease Network (PDN): (show all 30)


Acute Cystitis Acute Kidney Failure
Balanoposthitis Bladder Cancer
Bladder Disease Chronic Kidney Disease
Cystitis Cystitis Cystica
Epididymo-Orchitis Gout
Hydronephrosis Kidney Disease
Lipoma of Spermatic Cord Nephrolithiasis, X-Linked Recessive, with Renal Failure
Neurogenic Bladder Peyronie's Disease
Prostate Calculus Prostate Cancer
Prostate Carcinoma in Situ Prostatic Hypertrophy
Prostatitis Prostatocystitis
Radiation Cystitis Spermatocele
Ureterolithiasis Urethral Calculus
Urethral Stricture Urethritis
Urinary Tract Obstruction Vesicoureteral Reflux 1

Graphical network of the top 20 diseases related to Bladder Neck Obstruction:



Diseases related to Bladder Neck Obstruction
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Symptoms & Phenotypes for Bladder Neck Obstruction

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Drugs & Therapeutics for Bladder Neck Obstruction

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Drugs for Bladder Neck Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
2
Fesoterodine Approved Phase 4 286930-03-8, 286930-02-7 6918558
3
Alfuzosin Approved, Investigational Phase 4 81403-80-7 2092
4
Doxazosin Approved Phase 4 74191-85-8 3157
5 Neurotransmitter Agents Phase 4
6 Adrenergic Agents Phase 4
7 Adrenergic alpha-Antagonists Phase 4
8 Adrenergic alpha-1 Receptor Antagonists Phase 4
9 Adrenergic Antagonists Phase 4
10 Cholinergic Agents Phase 4
11 Muscarinic Antagonists Phase 4
12 Cholinergic Antagonists Phase 4
13 Tolterodine tartrate Phase 4 124937-52-6
14 Antihypertensive Agents Phase 4
15
Mirabegron Approved Phase 2 223673-61-8 9865528
16 Adrenergic beta-Agonists Phase 2
17 Adrenergic beta-3 Receptor Agonists Phase 2
18 Adrenergic Agonists Phase 2
19 Solifenacin succinate Phase 2 242478-38-2
20 Anesthetics

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double Blind, Placebo Controlled, Four Arm (Placebo, Tolterodine ER, Tamsulosin, and Tolterodine ER Plus Tamsulosin) Study To Evaluate The Clinical Efficacy And Safety Of Tolterodine ER 4 mg In Men Who Have Frequency and Urgency, With Or Without Urinary Urge Incontinence, With Or Without Bladder Outlet Obstruction Completed NCT00147654 Phase 4 Tolterodine ER 4 mg QD;Tamsulosin 0.4 mg QD
2 An Open Label Study to Measure the Efficacy of Fesoterodine (Toviaz) on Continued Detrusor Overactivity in Patients That Have Undergone Treatment for Bladder Outlet Obstruction Completed NCT00605319 Phase 4 Toviaz (Fesoterodine)
3 The Long Term Effects of Alfuzosin(Xatral XL) in LUTS/BPH Patients: Evaluation of Voiding and Storage Function According to Bladder Outlet Obstruction Grade and Bladder Contractility Completed NCT00696761 Phase 4 Alfuzosin;Alfuzosin;Alfuzosin;Alfuzosin
4 Antimuscarinics as the First-line Treatment for Male With International Prostate Symptom Score (IPSS) Voiding-to-storage Subscore Rati (IPSS-V/S)≤1-- A Prospective Randomized Study Comparing With α-blockers Completed NCT01661621 Phase 4 Detrusitol 4 mg QD;Doxazosin 4 mg QD
5 Effectiveness and Safety of Local Endoscopically-assisted Administration of Autologous Adipose-derived Regenerative Cells for Reduction of Risk of Postoperative Bladder Neck Contracture in Male Patients Unknown status NCT02869061 Phase 1, Phase 2
6 The Role Of Prophylactic Urethral Stenting With Memokath® 028SW in Patients Undergoing Prostate 125I Seed Implants For Prostate Carcinoma: A Phase I/II Study Completed NCT00252941 Phase 1, Phase 2
7 A Phase 2, Randomized, Double-blind, Parallel Group, Placebo Controlled, Multi-center Study to Evaluate the Urodynamics and Safety of YM178 in Male Subjects With Lower Urinary Tract Symptoms (LUTS) and Bladder Outlet Obstruction (BOO) Completed NCT00410514 Phase 2 Mirabegron;Placebo
8 A Phase 2, Randomized, Double-Blind, Parallel Group, Placebo Controlled, Multi-Center Study to Evaluate the Safety of the Co-administration of Solifenacin Succinate With 0.4 mg Tamsulosin Hydrochloride OCAS (TOCAS) Using Urodynamics in Male Subjects With Lower Urinary Tract Symptoms (LUTS) and Bladder Outlet Obstruction (BOO) Completed NCT00507455 Phase 2 solifenacin succinate;tamsulosin hydrochloride;Placebo to solifenacin;Placebo to tamsulosin
9 Diagnosis of Bladder Outlet Obstruction Using Dynamic Urine Vibration "Holter" in Comparison to Pressure Flow Study Unknown status NCT01388348
10 One-arm Feasibility and Prospective Pivotal Study to Assess the Safety and Efficacy of MediTate Temporary Implantable Nitinol Device (TIND) in Subjects Presenting Bladder Outlet Obstruction Secondary to BPH Completed NCT01436877
11 Impact of 80 Watt KTP Photoselective Laser Vaporization Prostatectomy on Severity of Obstruction in Benign Prostatic Hyperplasia: 6-Month Results of a Nonrandomized Prospective Trial Completed NCT00908427
12 Prevalence Rates of Bladder Outlet Obstruction and Detrusor Underactivity and Their Clinical and Urodynamic Findings in Women With ≥Stage II Cystocele Completed NCT03613324
13 Investigating the Role of microRNAs in the Regulation of Gene Expression and Organ Remodeling During Lower Urinary Tract Dysfunction, Including Bladder Pain Syndrome/Interstitial Cystitis (BPS), and Overactive Bladder Syndrome (OAB) Completed NCT01482676
14 An Open Prospective Multicenter Study Comparing the Urine Flow Measurements of Standard Clinic Flow Measurements vs Comercially Available Portable Digital Flow Meters and a Disposable Flow Meter in a Crossover and Randomized Order on Male BPH Subjects Completed NCT00710749
15 Urodynamically Age-specific Prevalence of Detrusor Underactivity and Bladder Outlet Obstruction in Female Voiding Dysfunction Without Cystocele Completed NCT04184752
16 Comparison Between Invasive Pressure Flow Study and Non-invasive Penile Cuff Test Completed NCT02031653
17 Prevalence of Detrusor Underactivity and Bladder Outlet Obstruction in Women With Cystocele and Changes of Voiding Function After Cystocele Completed NCT04184128
18 Bipolar Transurethral Enucleation (BipolEP) vs Bipolar Transurethral Resection of the Prostate: A Prospective Interventional Multi-center Randomized Controlled Trial Recruiting NCT03503721
19 Prostatic Artery Embolization (PAE) in Patients With Advanced Prostate Cancer: A Pilot Study. Recruiting NCT03457805
20 Urodynamics and Clinical Factors That Are Associated With Bladder Over-sensitivity Recruiting NCT03486639
21 Concomitant Renal and Urinary Bladder Allograft Transplantation Not yet recruiting NCT04626167 Early Phase 1
22 Short- and Medium-term Safety/Effectiveness Analysis of Low Energy Holmium Laser Enucleation of the Prostate (HoLEP) Not yet recruiting NCT04514718
23 Bladder Outlet Obstruction Observation Using Dynamic Urine Vibration "Holter" With Correlation to Pressure Flow Study and Uroflowmetry. Suspended NCT01779349

Search NIH Clinical Center for Bladder Neck Obstruction

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Phenoxybenzamine
Phenoxybenzamine Hydrochloride

Cochrane evidence based reviews: urinary bladder neck obstruction

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Genetic Tests for Bladder Neck Obstruction

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Anatomical Context for Bladder Neck Obstruction

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MalaCards organs/tissues related to Bladder Neck Obstruction:

40
Prostate, Spinal Cord, Smooth Muscle
Sources

Publications for Bladder Neck Obstruction

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Articles related to Bladder Neck Obstruction:

(show top 50) (show all 386)
# Title Authors PMID Year
1
Patients presenting with lower urinary tract symptoms who most deserve to be investigated for primary bladder neck obstruction. 61
33603071 2021
2
A novel histologic finding in male patients with bladder outlet obstruction: a possible etiopathogenesis of Marion's disease? 61
33611606 2021
3
Severe urinary tract damage secondary to primary bladder neck obstruction in women. 61
33740013 2021
4
Labial adhesion in a postmenopausal female: A case report. 61
32590764 2020
5
Conservative treatment of asymptomatic ectopic ureterocele: A report of two cases. 61
32743466 2020
6
Primary Bladder Neck Obstruction in a Young Woman: A Novel Technique of Bladder Neck Incision Using Holmium Laser. 61
33102714 2020
7
[Outcome of surgical management and pathogenesis of female primary bladder neck obstruction]. 61
31848503 2019
8
Value of Real-Time Shear Wave Elastography Versus Acoustic Radiation Force Impulse Imaging in the Diagnosis of Female Bladder Neck Obstruction. 61
30680774 2019
9
[Clinical characteristics and treatment of female stress urinary incontinence combined with bladder neck obstruction]. 61
31484278 2019
10
Congenital urinary tract obstruction. 61
30819578 2019
11
Primary Bladder Neck Obstruction. 61
31768132 2019
12
Role of poor urethral sphincter relaxation in men with voiding dysfunction refractory to α-blocker therapy: Clinical characteristics and predictive factors. 61
28840669 2019
13
Female urethral dilatation (bougierung): a case report. 61
30563562 2018
14
[Finite element analysis of male lower urinary tract based on the collodion slice images]. 61
30124023 2018
15
Patency and Incontinence Rates After Robotic Bladder Neck Reconstruction for Vesicourethral Anastomotic Stenosis and Recalcitrant Bladder Neck Contractures: The Trauma and Urologic Reconstructive Network of Surgeons Experience. 61
29777787 2018
16
Management of Postoperative Lower Urinary Tract Symptoms (LUTS) After Pelvic Organ Prolapse (POP) Repair. 61
30043287 2018
17
The outcomes of transurethral incision/resection of the prostate (TUIP/TURP) performed early after renal transplantation. 61
29511589 2018
18
Urodynamic outcomes of tamsulosin in the treatment of primary bladder neck obstruction in men. 61
29343910 2018
19
Gait analysis of young male patients diagnosed with primary bladder neck obstruction. 61
28601565 2017
20
Female primary bladder neck obstruction: role of videourodynamics and treatment options in a rare clinical entity. 61
27886351 2017
21
Bilateral Hydroureteronephrosis with a Hypertrophied, Trabeculated Urinary Bladder. 61
28894411 2017
22
The Role of Video Urodynamics in the Management of the Valve Bladder. 61
28233231 2017
23
The Long-term Effect of Superficial Bladder Neck Incision on Ejaculation and Incontinence in Boys with Primary and Secondary Bladder Neck Obstruction. 61
28752084 2017
24
Protective Effects of Antimuscarinics on the Bladder Remodeling After Bladder Outlet Obstruction. 61
29176315 2017
25
Primary bladder neck obstruction may be determined by postural imbalances. 61
27876119 2016
26
Single laser incision for treatment of congenital bladder neck sclerosis: new technique. 61
27174536 2016
27
Patterns of Care for Newly Diagnosed Benign Prostatic Hyperplasia in the United States. 61
26872842 2016
28
Controlled transurethral resection and incision of the bladder neck to treat female primary bladder neck obstruction: Description of a novel surgical procedure. 61
27037830 2016
29
Application of Acoustic Radiation Force Impulse Imaging for Diagnosis of Female Bladder Neck Obstruction. 61
27162282 2016
30
Pharmacologic management of non-neurogenic functional obstruction in women. 61
27095013 2016
31
Can Classic Bladder Exstrophy be Safely and Successfully Reconstructed at a Low Volume Center? 61
26144337 2016
32
[Clinical observation of acupoint application therapy on senile female bladder neck obstruction]. 61
26964164 2015
33
[Female urethral obstruction and bladder neck stenosis - fact or myth - how to proceed]. 61
26378388 2015
34
Use of transvaginal ultrasound in females with primary bladder neck obstruction. A preliminary study. 61
26150036 2015
35
Inguinal Herniation of the Urinary Bladder Presenting as Recurrent Urinary Retention. 61
26075132 2015
36
Transurethral incision of the bladder neck in a woman with primary bladder neck obstruction after kidney transplantation. 61
25861513 2015
37
Bladder neck disease and kidney damage. 61
25641480 2014
38
Bladder outlet obstruction in women: functional causes. 61
25059639 2014
39
Giant bladder stone: A case report and review of the literature. 61
26328176 2014
40
Fetal therapy for the treatment of congenital bladder neck obstruction. 61
24934451 2014
41
Thulium laser resection for bladder neck obstruction in women. 61
24988202 2014
42
Natural history of prostate cancer. 61
24914836 2014
43
Bladder neck incision for female bladder neck obstruction: long-term outcomes. 61
24680443 2014
44
Transurethral bladder neck incision in women with primary bladder neck obstruction. 61
24496715 2014
45
Endoscopic surgery as an adjuvant treatment modality before or after definitive correction of cloacal anomalies. 61
24456819 2014
46
[Drug therapy of urethral diseases]. 61
24183087 2013
47
Acute Urinary Retention in a 47-month-old Girl Caused by the Giant Fecaloma. 61
24224155 2013
48
Stem cell therapy in bladder dysfunction: where are we? And where do we have to go? 61
24151627 2013
49
[Chronic urinary retention in women caused by primary bladder neck obstruction : report of two cases treated successfully with transurethral resection of bladder neck]. 61
23412123 2013
50
Lower Urinary Tract Symptoms and Video-Urodynamic Characteristics of Women with Clinically Unsuspected Bladder Outlet Obstruction. 61
26663244 2013
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Variations for Bladder Neck Obstruction

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Expression for Bladder Neck Obstruction

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Search GEO for disease gene expression data for Bladder Neck Obstruction.
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Pathways for Bladder Neck Obstruction

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GO Terms for Bladder Neck Obstruction

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Biological processes related to Bladder Neck Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 8.62 TAC1 ACE

Molecular functions related to Bladder Neck Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 KLK3 ACE
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Sources for Bladder Neck Obstruction

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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