SCCB
MCID: BLD173
MIFTS: 34

Bladder Small Cell Carcinoma (SCCB)

Categories: Cancer diseases, Endocrine diseases, Nephrological diseases, Neuronal diseases, Rare diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Bladder Small Cell Carcinoma

MalaCards integrated aliases for Bladder Small Cell Carcinoma:

Name: Bladder Small Cell Carcinoma 11 14
Small Cell Bladder Cancer 19 58 71
Poorly Differentiated Neuroendocrine Carcinoma of the Bladder 19 58
Small Cell Carcinoma of the Urinary Bladder 19 58
Small Cell Carcinoma of the Bladder 19 58
Small Cell Bladder Carcinoma 19 58
Sccb 19 58

Characteristics:


Prevelance:

Small Cell Carcinoma of the Bladder: 1-9/1000000 (United States) <1/1000000 (Europe) 58

Age Of Onset:

Small Cell Carcinoma of the Bladder: Adult 58

Classifications:

Orphanet: 58  
Rare urogenital diseases
Rare endocrine diseases


External Ids:

Disease Ontology 11 DOID:0080902
Orphanet 58 ORPHA284400
UMLS 71 C2212594

Summaries for Bladder Small Cell Carcinoma

GARD: 19 Small cell carcinoma of the bladder (SCCB) is a very rare, poorly differentiated neuroendocrine epithelial bladder tumor characterized clinically by hematuria and/or dysuria and a highly aggressive course.

MalaCards based summary: Bladder Small Cell Carcinoma, also known as small cell bladder cancer, is related to lung oat cell carcinoma and small cell cancer of the lung. An important gene associated with Bladder Small Cell Carcinoma is SYP (Synaptophysin). Affiliated tissues include breast, prostate and lymph node, and related phenotypes are hematuria and bladder neoplasm

Orphanet: 58 Small cell carcinoma of the bladder (SCCB) is a very rare, poorly differentiated neuroendocrine epithelial bladder tumor characterized clinically by hematuria and/or dysuria and a highly aggressive course.

Disease Ontology: 11 A bladder carcinoma that is characterized as an undifferentiated neoplasm composed of primitive-appearing cells.

Related Diseases for Bladder Small Cell Carcinoma

Diseases related to Bladder Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)
# Related Disease Score Top Affiliating Genes
1 lung oat cell carcinoma 30.9 SYP ENO2
2 small cell cancer of the lung 30.8 SYP NCAM1 ENO2
3 small cell carcinoma 30.6 SYP NCAM1 ENO2
4 prostate small cell carcinoma 30.5 SYP ENO2
5 mixed cell type cancer 30.4 SYP ENO2
6 neuroendocrine tumor 30.4 SYP NCAM1 ENO2
7 neuroendocrine carcinoma 30.4 SYP NCAM1 ENO2
8 urinary bladder small cell neuroendocrine carcinoma 30.1 SYP NCAM1 ENO2
9 gastrointestinal stromal tumor 30.1 SYP NCAM1 ENO2
10 suppression of tumorigenicity 12 29.9 SYP NKX3-1 ENO2
11 rhabdomyosarcoma 29.8 TERT SYP NCAM1 ENO2
12 transitional cell carcinoma 10.6
13 rare tumor 10.4
14 bladder diverticulum 10.3
15 ataxia with vitamin e deficiency 10.3
16 bladder urothelial carcinoma 10.3
17 granular cell tumor 10.3 SYP ENO2
18 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
19 cerebral neuroblastoma 10.3 SYP ENO2
20 neuronal intestinal dysplasia, type b 10.3 SYP ENO2
21 thymus small cell carcinoma 10.3 SYP ENO2
22 optic nerve astrocytoma 10.3 SYP ENO2
23 breast neuroendocrine neoplasm 10.3 SYP ENO2
24 cloacogenic carcinoma 10.3 SYP ENO2
25 pineal region teratoma 10.3 SYP ENO2
26 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.3 SYP ENO2
27 cauda equina neoplasm 10.3 SYP ENO2
28 colon neuroendocrine neoplasm 10.3 SYP ENO2
29 bile duct mucinous adenocarcinoma 10.3 SYP ENO2
30 ampulla of vater benign neoplasm 10.3 SYP ENO2
31 partial cryptophthalmia 10.3 SYP ENO2
32 carotid body cancer 10.3 SYP ENO2
33 pineal region choriocarcinoma 10.3 SYP ENO2
34 intracranial primitive neuroectodermal tumor 10.3 SYP ENO2
35 auditory system cancer 10.3 SYP ENO2
36 cerebellar liponeurocytoma 10.3 SYP ENO2
37 nodular ganglioneuroblastoma 10.3 SYP ENO2
38 ganglioneuroblastoma 10.3 SYP ENO2
39 frontal lobe neoplasm 10.3 SYP ENO2
40 lipoma of spermatic cord 10.3 SYP ENO2
41 pineocytoma 10.3 SYP ENO2
42 appendix carcinoid tumor 10.3 SYP ENO2
43 jejunal neoplasm 10.3 SYP ENO2
44 melanotic neuroectodermal tumor 10.3 SYP ENO2
45 central nervous system mesenchymal non-meningothelial tumor 10.3 SYP ENO2
46 ectomesenchymoma 10.3 SYP ENO2
47 mature teratoma 10.3 SYP ENO2
48 mature teratoma of the ovary 10.3 SYP ENO2
49 myoblastoma 10.3 SYP ENO2
50 spinal cord oligodendroglioma 10.3 SYP ENO2

Graphical network of the top 20 diseases related to Bladder Small Cell Carcinoma:



Diseases related to Bladder Small Cell Carcinoma

Symptoms & Phenotypes for Bladder Small Cell Carcinoma

Human phenotypes related to Bladder Small Cell Carcinoma:

58 30 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hematuria 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0000790
2 bladder neoplasm 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0009725
3 dysuria 58 30 Frequent (33%) Frequent (79-30%)
HP:0100518
4 abdominal pain 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002027
5 recurrent urinary tract infections 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000010
6 hypercalcemia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0003072

Drugs & Therapeutics for Bladder Small Cell Carcinoma

Search Clinical Trials, NIH Clinical Center for Bladder Small Cell Carcinoma

Genetic Tests for Bladder Small Cell Carcinoma

Anatomical Context for Bladder Small Cell Carcinoma

Organs/tissues related to Bladder Small Cell Carcinoma:

MalaCards : Breast, Prostate, Lymph Node, Adrenal Gland, Lung, Spinal Cord, Skeletal Muscle

Publications for Bladder Small Cell Carcinoma

Articles related to Bladder Small Cell Carcinoma:

(show top 50) (show all 316)
# Title Authors PMID Year
1
Long-term complete response in small cell bladder carcinoma treated with carboplatin, etoposide, and atezolizumab. 62
36335330 2022
2
Long-term Outcomes of Local and Metastatic Small Cell Carcinoma of the Urinary Bladder and Genomic Analysis of Patients Treated With Neoadjuvant Chemotherapy. 62
35676169 2022
3
Clinical characteristics and treatment outcomes of patients with small cell carcinoma of the urinary bladder. 62
36204354 2022
4
Small cell carcinoma of the urinary bladder: Distinctive cytological characteristics and Cyto-histologic correlation. 62
35427925 2022
5
Identification of potential biomarkers and novel therapeutic targets through genomic analysis of small cell bladder carcinoma and associated clinical outcomes. 62
35662501 2022
6
Pure small cell neuroendocrine carcinoma of urinary bladder: A case report. 62
36034611 2022
7
Small cell carcinoma of the bladder: A population-based analysis of long-term outcomes after radical cystectomy and bladder conservation with chemoradiotherapy. 62
34582342 2022
8
Small-cell neuroendocrine tumor of the bladder: A rare disease in a low-risk woman. 62
34786346 2022
9
Hemorrhagic brain metastasis from small-cell carcinoma of the urinary bladder. 62
35127220 2022
10
Photonic crystal barcodes assembled from dendritic silica nanoparticles for the multiplex immunoassays of ovarian cancer biomarkers. 62
34985054 2022
11
Phenotypic and Functional Characterizations of Mesenchymal Stem/Stromal Cells Isolated From Human Cranial Bone Marrow. 62
35747205 2022
12
Clinical value of 18FDG PET/MRI in muscle-invasive, locally advanced, and metastatic bladder cancer. 62
34140245 2021
13
Lurbinectedin for metastatic small-cell bladder carcinoma. 62
33951544 2021
14
Treatment Outcomes for Small Cell Carcinoma of the Bladder: Results From a UK Patient Retrospective Cohort Study. 62
33561506 2021
15
Primary Small Cell Carcinoma of the Bladder. 62
34164246 2021
16
Small Cell Bladder Cancer Response to Second-line and Beyond Checkpoint Inhibitor Therapy: Retrospective Experience. 62
33358150 2021
17
Urothelial Cancers with Small Cell Variant Histology Have Confirmed High Tumor Mutational Burden, Frequent TP53 and RB Mutations, and a Unique Gene Expression Profile. 62
32061548 2021
18
Neuroendocrine tumors of the urinary bladder - Report of two cases. 62
34458173 2021
19
Viability of Lactobacillus rhamnosus GG in Simulated Gastrointestinal Conditions and After Baking White Pan Bread at Different Temperature and Time Regimes. 62
32960301 2020
20
[A Case of Small Cell Carcinoma of the Bladder]. 62
32988169 2020
21
[Pure small cell carcinoma of the urinary bladder: a clinicopathologic and prognostic study]. 62
32892560 2020
22
Major Durable Response of Pembrolizumab in Chemotherapy Refractory Small Cell Bladder Cancer: A Case Report. 62
33082749 2020
23
Small cell carcinoma of the bladder with coexisting prostate adenocarcinoma: two cases report and literature review. 62
32859184 2020
24
Survival of Contemporary Patients With Non-metastatic Small-cell Carcinoma of Urinary Bladder, According to Alternative Treatment Modalities. 62
32146153 2020
25
[Arterial hypertension after heart transplantation]. 62
32720616 2020
26
A Rare Case of Small Cell Carcinoma of the Urinary Bladder. 62
32676247 2020
27
Urothelial-to-Neural Plasticity Drives Progression to Small Cell Bladder Cancer. 62
32521509 2020
28
Clinical outcomes of patients with pure small cell carcinoma of the urinary bladder. 62
31463895 2020
29
Perioperative Chemotherapy in Poorly Differentiated Neuroendocrine Neoplasia of the Bladder: A Multicenter Analysis. 62
32380705 2020
30
Evaluation of metastases to the pancreas with fine needle aspiration: A case series from a single centre with review of the literature. 62
31788890 2020
31
Analysis on thermal behavior of fluorides and cyanides for heat-treating spent cathode carbon blocks from aluminum smelters by TG/DSC-MS & ECSA®. 62
31830602 2020
32
A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes. 62
31871155 2020
33
TTF-1 Positive Primary Small Cell Carcinoma of the Breast: A Case Report and Review of the Literature. 62
32411090 2020
34
Small cell carcinoma of the bladder presenting with paraneoplastic syndrome of inappropriate antidiuretic hormone. 62
31888898 2019
35
Development and validation of a nomogram to predict the prognosis of patients with squamous cell carcinoma of the bladder. 62
31808514 2019
36
Nomograms to predict individual prognosis of patients with squamous cell carcinoma of the urinary bladder. 62
31818271 2019
37
Bilateral Cavernous Sinus Syndrome, Pituitary Macroadenoma, and Postoperative Loss of Vision: A Case Report. 62
31449072 2019
38
Advanced small-cell bladder cancer into a ureterocele: A case report and literature review. 62
31440452 2019
39
Small cell carcinoma of the bladder: the characteristics of molecular alterations, treatment, and follow-up. 62
31664527 2019
40
Primary small cell carcinoma of the urinary bladder. 62
31570346 2019
41
The oncological outcomes of small cell carcinoma of the bladder. 62
30526804 2019
42
Prognostic Variables in Patients With Non-metastatic Small-cell Neuroendocrine Carcinoma of the Bladder: A Population-Based Study. 62
31160193 2019
43
Organ-preserving approach via radiotherapy for small cell carcinoma of the bladder: an analysis based on the Japanese Radiation Oncology Study Group (JROSG) survey. 62
31034572 2019
44
First Case of Cellular Cannibalism in Small-Cell Carcinoma of the Bladder Detected in Peripheral Blood. 62
30809987 2019
45
Molybdenum disulfide-integrated photonic barcodes for tumor markers screening. 62
30933711 2019
46
Small cell bladder cancer: should we consider prophylactic cranial irradiation? 62
30521161 2019
47
Immune Exclusion Is Frequent in Small-Cell Carcinoma of the Bladder. 62
31191745 2019
48
Transcriptomic and Protein Analysis of Small-cell Bladder Cancer (SCBC) Identifies Prognostic Biomarkers and DLL3 as a Relevant Therapeutic Target. 62
30327311 2019
49
Prognosis of early stage small cell bladder cancer is not always dismal. 62
31798978 2019
50
Small-cell Carcinomas of the Urinary Bladder and Prostate: TERT Promoter Mutation Status Differentiates Sites of Malignancy and Provides Evidence of Common Clonality Between Small-cell Carcinoma of the Urinary Bladder and Urothelial Carcinoma. 62
28753872 2018

Variations for Bladder Small Cell Carcinoma

Expression for Bladder Small Cell Carcinoma

Search GEO for disease gene expression data for Bladder Small Cell Carcinoma.

Pathways for Bladder Small Cell Carcinoma

GO Terms for Bladder Small Cell Carcinoma

Sources for Bladder Small Cell Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....