MCID: BLD047
MIFTS: 39

Bladder Squamous Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases, Skin diseases

Aliases & Classifications for Bladder Squamous Cell Carcinoma

MalaCards integrated aliases for Bladder Squamous Cell Carcinoma:

Name: Bladder Squamous Cell Carcinoma 12 15 17 72
Epidermoid Carcinoma of the Urinary Bladder 12
Squamous Cell Carcinoma of Bladder 12
Carcinoma Squamous Cell Bladder 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3742
NCIt 50 C4031
UMLS 72 C0279681

Summaries for Bladder Squamous Cell Carcinoma

Disease Ontology : 12 A carcinoma of bladder that is manifested in squamous cells of the bladder.

MalaCards based summary : Bladder Squamous Cell Carcinoma, also known as epidermoid carcinoma of the urinary bladder, is related to squamous cell papilloma and mature teratoma, and has symptoms including dysuria An important gene associated with Bladder Squamous Cell Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Gastric cancer and Endometrial cancer. The drugs Epirubicin and BCG vaccine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, t cells and lung, and related phenotypes are digestive/alimentary and liver/biliary system

Related Diseases for Bladder Squamous Cell Carcinoma

Diseases related to Bladder Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 30.3 TP53 CDKN2A
2 mature teratoma 30.1 TP53 BRAF
3 squamous cell carcinoma 30.1 TP53 S100A7 CDKN2A BRAF
4 transitional cell carcinoma 29.3 UPK2 TP53 CDKN2A BRAF
5 bladder cancer 28.9 UPK2 TP53 CDKN2A
6 keratinizing squamous cell carcinoma 10.3 TP53 CDKN2A
7 scrotal carcinoma 10.3 TP53 CDKN2A
8 vulva squamous cell carcinoma 10.3 TP53 CDKN2A
9 bartholin's gland disease 10.3 TP53 CDKN2A
10 nasal cavity adenocarcinoma 10.3 TP53 CDKN2A
11 vulvar disease 10.3 TP53 CDKN2A
12 thyroid lymphoma 10.3 TP53 CDKN2A
13 anal squamous cell carcinoma 10.3 TP53 CDKN2A
14 gastric adenosquamous carcinoma 10.3 TP53 CDKN2A
15 glycogen-rich clear cell breast carcinoma 10.3 TP53 CDKN2A
16 megaesophagus 10.3 TP53 CDKN2A
17 oral leukoplakia 10.3 TP53 CDKN2A
18 uterus carcinoma in situ 10.3 TP53 CDKN2A
19 cervix uteri carcinoma in situ 10.3 TP53 CDKN2A
20 anogenital venereal wart 10.3 TP53 CDKN2A
21 meningeal melanomatosis 10.3 TP53 CDKN2A
22 suppressor of tumorigenicity 3 10.3 TP53 CDKN2A
23 dedifferentiated liposarcoma 10.3 TP53 CDKN2A
24 liposarcoma 10.3 TP53 CDKN2A
25 endocervical adenocarcinoma 10.3 TP53 CDKN2A
26 cervical adenocarcinoma 10.3 TP53 CDKN2A
27 penile disease 10.3 TP53 CDKN2A
28 cervix small cell carcinoma 10.3 TP53 CDKN2A
29 small cell carcinoma 10.3 TP53 CDKN2A
30 basaloid squamous cell carcinoma 10.3 TP53 CDKN2A
31 verrucous carcinoma 10.3 TP53 CDKN2A
32 necrotizing sialometaplasia 10.3 TP53 CDKN2A
33 tongue disease 10.3 TP53 CDKN2A
34 optic nerve neoplasm 10.3 TP53 CDKN2A
35 tonsil cancer 10.3 TP53 CDKN2A
36 juvenile pilocytic astrocytoma 10.2 TP53 CDKN2A
37 vulva cancer 10.2 TP53 CDKN2A
38 oropharynx cancer 10.2 TP53 CDKN2A
39 pharynx cancer 10.2 TP53 CDKN2A
40 barrett's adenocarcinoma 10.2 TP53 CDKN2A
41 laryngeal disease 10.2 TP53 CDKN2A
42 pancreatic ductal carcinoma 10.2 TP53 CDKN2A
43 inverted papilloma 10.2 TP53 CDKN2A
44 skin squamous cell carcinoma 10.2 TP53 CDKN2A
45 cervix carcinoma 10.2 TP53 CDKN2A
46 cellular schwannoma 10.2 TP53 CDKN2A
47 in situ carcinoma 10.2 TP53 CDKN2A
48 penile cancer 10.2 TP53 CDKN2A
49 histiocytic sarcoma 10.2 CDKN2A BRAF
50 nasopharyngeal disease 10.2 TP53 CDKN2A

Graphical network of the top 20 diseases related to Bladder Squamous Cell Carcinoma:



Diseases related to Bladder Squamous Cell Carcinoma

Symptoms & Phenotypes for Bladder Squamous Cell Carcinoma

UMLS symptoms related to Bladder Squamous Cell Carcinoma:


dysuria

MGI Mouse Phenotypes related to Bladder Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.56 BRAF CDKN2A CREBBP TP53
2 liver/biliary system MP:0005370 9.46 BRAF CDKN2A CREBBP TP53
3 neoplasm MP:0002006 9.26 BRAF CDKN2A CREBBP TP53
4 respiratory system MP:0005388 8.92 BRAF CDKN2A CREBBP TP53

Drugs & Therapeutics for Bladder Squamous Cell Carcinoma

Drugs for Bladder Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epirubicin Approved Phase 3 56420-45-2 41867
2
BCG vaccine Investigational Phase 3
3 Topoisomerase Inhibitors Phase 3
4 Immunologic Factors Phase 3
5 Alkylating Agents Phase 3
6 Anti-Infective Agents Phase 3
7 Adjuvants, Immunologic Phase 3
8 Mitomycins Phase 3
9 Anti-Bacterial Agents Phase 3
10 Interferon-alpha Phase 3
11 Antibiotics, Antitubercular Phase 3
12 Nucleic Acid Synthesis Inhibitors Phase 3
13 Antiviral Agents Phase 3
14 Vaccines Phase 3
15 interferons Phase 3
16
leucovorin Approved Phase 2 58-05-9 143 6006
17
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
18 Piritrexim Investigational Phase 2 72732-56-0
19
Rubitecan Investigational Phase 2 91421-42-0
20
Camptothecin Experimental Phase 2 7689-03-4
21 Folic Acid Antagonists Phase 2
22 Folate Phase 2
23 Vitamin B9 Phase 2
24 Vitamin B Complex Phase 2
25 topoisomerase I inhibitors Phase 2
26 Analgesics Phase 1
27 Antibodies Phase 1
28 Antibodies, Monoclonal Phase 1
29 Analgesics, Non-Narcotic Phase 1
30 Peripheral Nervous System Agents Phase 1
31 Immunoglobulins Phase 1
32 Interleukin-2 Phase 1
33 Mitogens Phase 1
34
Dimenhydrinate Approved 523-87-5 441281
35
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
36
Ethanol Approved 64-17-5 702
37 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HYMN: A Randomized Controlled Phase III Trial Comparing Hyperthermia Plus Mitomycin to a Second Course of Bacillus Calmette-Guerin or Standard Therapy in Patients With Recurrence of Non-Muscle Invasive Bladder Cancer Following Induction or Maintenance Bacillus Calmette-Guerin Therapy Unknown status NCT01094964 Phase 3 epirubicin hydrochloride;mitomycin C
2 Bladder Cancer: Open Versus Laparoscopic or Robotic Cystectomy. A Study to Determine the Feasibility of Randomization to Open Versus Minimal Access Cystectomy in Patients With Bladder Cancer. Unknown status NCT01196403 Phase 2
3 PHASE II STUDY OF PIRITREXIM IN ADVANCED CARCINOMA OF THE UROTHELIUM Completed NCT00002914 Phase 2 piritrexim
4 Open Label Phase II Study on RFS 2000 (9-Nitro-Camptothecin, 9-NC) Administered as a "5 Days On-2 Days Off" Oral Treatment in Advanced/Metastatic Urothelial Tract Tumors Completed NCT00006026 Phase 2 rubitecan
5 Image Guided Dose Escalated Adaptive Bladder Radiotherapy Unknown status NCT01124682 Phase 1
6 Phase I Dose-Escalation Study of the Pharmacokinetic, Safety, Tolerability, and Biologic Activity of huKS-IL-2 Administered Daily as a 1-Hour Intravenous Infusion for Five Consecutive Days for Treatment of Refractory Epithelial Cancer Completed NCT00016237 Phase 1
7 VISTA (VIrus Specific T Cells and Adenovirus): A First in Human Phase I Trial of Binary Oncolytic Adenovirus in Combination With HER2-Specific CAR VST Cells in Patients With Advanced HER2 Positive Solid Tumors Not yet recruiting NCT03740256 Phase 1
8 Study of The Examination of Sentinel Lymph Nodes for OX-40 Expression in Patients With Cancer Completed NCT00900302

Search NIH Clinical Center for Bladder Squamous Cell Carcinoma

Genetic Tests for Bladder Squamous Cell Carcinoma

Anatomical Context for Bladder Squamous Cell Carcinoma

MalaCards organs/tissues related to Bladder Squamous Cell Carcinoma:

41
Lymph Node, T Cells, Lung

Publications for Bladder Squamous Cell Carcinoma

Articles related to Bladder Squamous Cell Carcinoma:

(show top 50) (show all 59)
# Title Authors PMID Year
1
Psoriasin (S100A7): a putative urinary marker for the follow-up of patients with bladder squamous cell carcinomas. 9 38
10197442 1999
2
Bladder squamous cell carcinomas express psoriasin and externalize it to the urine. 9 38
8618345 1996
3
Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets. 38
30927206 2019
4
Lung Involvement in Chronic Schistosomiasis with Bladder Squamous Cell Carcinoma. 38
30460893 2018
5
Frequent PD-L1 Protein Expression and Molecular Correlates in Urinary Bladder Squamous Cell Carcinoma. 38
29980330 2018
6
Bladder squamous cell cancer accompanied by Trousseau's syndrome: a case report. 38
29636934 2018
7
TWIST2 EXPRESSIONS IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE URINARY BLADDER SHOWED DOWN REGULATION CORRELATED WITH GOOD SURVIVAL AND LOW INCIDENCE OF DISTANT METASTASIS. 38
30157337 2017
8
[Urinary schistosomiasis and cancer]. 38
28185084 2017
9
Risk factors for development of primary bladder squamous cell carcinoma. 38
27869492 2017
10
Alterations of mTOR and PTEN protein expression in schistosomal squamous cell carcinoma and urothelial carcinoma. 38
26916953 2016
11
High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder. 38
26965579 2016
12
Bladder squamous cell carcinoma in pregnancy. 38
26467844 2016
13
Primary squamous cell carcinoma of bladder exstrophy in an adult. 38
25878418 2015
14
Small cell carcinoma of the bladder associated with schistosomiasis: a case report. 38
25803993 2014
15
Vesicoenteric fistula due to bladder squamous cell carcinoma. 38
25045451 2014
16
Squamous cell carcinogenesis and squamous cell carcinoma of the urinary bladder: a contemporary review with focus on nonbilharzial squamous cell carcinoma. 38
23433891 2014
17
Novel markers of squamous differentiation in the urinary bladder. 38
23806524 2013
18
Biopsy case mix and diagnostic yield at a Malawian central hospital. 38
24358421 2013
19
Cloacal anomaly with bladder tumor. 38
23956519 2013
20
c-KIT positive schistosomal urinary bladder carcinoma are frequent but lack KIT gene mutations. 38
23534715 2013
21
p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma. 38
22684221 2012
22
Expression of calcium binding protein S100 A7 (psoriasin) in laryngeal carcinoma. 38
22936138 2012
23
Radiation treatment of bladder squamous cell carcinoma in a patient with spina bifida: A case report. 38
22709884 2012
24
Urinary schistosomiasis with simultaneous bladder squamous cell carcinoma and transitional cell carcinoma. 38
23109968 2012
25
Prognostic value of cyclooxygenase-2 expression in squamous cell carcinoma of the bladder. 38
21255800 2011
26
Squamous cell carcinoma of the bladder associated with chronic irritation related to a migrated intrauterine device. 38
20367452 2010
27
Enterovesical fistula caused by a bladder squamous cell carcinoma. 38
19725163 2009
28
Tumourigenic effect of Schistosoma haematobium total antigen in mammalian cells. 38
19659903 2009
29
Urothelial carcinoma versus squamous cell carcinoma of bladder: is survival different with stage adjustment? 38
19193403 2009
30
A panel of angiogenic factors for early bladder cancer detection: enzyme immunoassay and Western blot. 38
19185322 2009
31
Treatment of locally advanced and metastatic bladder cancer. 38
19468366 2008
32
New developments in first- and second-line chemotherapy for transitional cell, squamous cell and adenocarcinoma of the bladder. 38
17762632 2007
33
Rapid diagnosis and follow up of bladder cancer patients using urinary high molecular weight cytokeratins. 38
16705457 2006
34
Survival from rare cancer in adults: a population-based study. 38
16455477 2006
35
[Squamous cell carcinoma of bladder producing granulocyte colony-stimulating factor (G-CSF): a case report]. 38
15773367 2005
36
Bladder squamous cell carcinoma. 38
15143234 2004
37
Muscle invasive schistosomal squamous cell carcinoma of the urinary bladder: frequency and prognostic significance of p53, BCL-2, HER2/neu, and proliferation (MIB-1). 38
14991535 2004
38
Bladder squamous cell carcinoma biomarkers derived from proteomics. 38
10892722 2000
39
Squamous cell carcinoma of the bladder: a ten-year retrospective study. 38
10074727 1998
40
Enhanced tumorigenicity of rat bladder squamous cell carcinoma cells after abrogation of gap junctional intercellular communication. 38
9685850 1998
41
Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation. 38
9515818 1998
42
Squamous cell carcinoma of bladder. 38
9146594 1997
43
Human papillomavirus and schistosomiasis associated bladder cancer. 38
9292149 1997
44
Expression of glutathione S-transferase activity and glutathione content in squamous cell carcinoma of bladder associated with schistosomiasis in a population in Egypt. 38
9060083 1997
45
[Epidermoid carcinoma of the bladder. Apropos of 14 cases]. 38
9412343 1997
46
Human papillomavirus in cyclophosphamide and diverticulum-associated squamous cell carcinoma of urinary bladder: a case report. 38
8705886 1996
47
Bladder squamous cell carcinoma with human papilloma virus type 6 [HPV 6]. 38
8749958 1995
48
UNME/K1: an IgG2a monoclonal antibody specific to cytokeratin of human urinary bladder squamous cell carcinoma. 38
1712997 1991
49
[Epidermoid carcinoma of the bladder]. 38
2057863 1991
50
Squamous cell carcinoma of bladder after successful intravesical therapy with Bacillus Calmette-Guérin. 38
2763404 1989

Variations for Bladder Squamous Cell Carcinoma

Expression for Bladder Squamous Cell Carcinoma

Search GEO for disease gene expression data for Bladder Squamous Cell Carcinoma.

Pathways for Bladder Squamous Cell Carcinoma

Pathways related to Bladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 TP53 CDKN2A BRAF
2
Show member pathways
12.41 TP53 CREBBP CDKN2A BRAF
3
Show member pathways
12.39 TP53 CDKN2A BRAF
4
Show member pathways
12.38 TP53 CREBBP BRAF
5 12.35 TP53 CREBBP CDKN2A BRAF
6
Show member pathways
12.29 TP53 CREBBP BRAF
7 12.23 TP53 CREBBP CDKN2A
8 12.06 TP53 CREBBP CDKN2A
9 12.05 TP53 CREBBP CDKN2A
10 11.96 TP53 CREBBP CDKN2A
11
Show member pathways
11.76 TP53 CREBBP BRAF
12 11.69 TP53 CREBBP CDKN2A
13
Show member pathways
11.5 TP53 CDKN2A
14 11.49 TP53 CDKN2A
15 11.48 TP53 CDKN2A BRAF
16 11.43 TP53 CREBBP
17 11.37 TP53 CREBBP
18 11.37 TP53 CREBBP CDKN2A
19 11.36 TP53 CDKN2A BRAF
20
Show member pathways
11.32 TP53 CREBBP
21 11.29 TP53 CDKN2A
22 11.17 TP53 CREBBP
23 11.05 TP53 CDKN2A
24 11 TP53 CDKN2A BRAF
25
Show member pathways
10.85 TP53 CDKN2A
26 10.84 TP53 CDKN2A
27 10.53 TP53 CREBBP CDKN2A

GO Terms for Bladder Squamous Cell Carcinoma

Biological processes related to Bladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.43 TP53 CDKN2A BRAF
2 Ras protein signal transduction GO:0007265 9.37 TP53 CDKN2A
3 cellular response to drug GO:0035690 9.32 TP53 BRAF
4 cellular response to UV GO:0034644 9.16 TP53 CREBBP
5 protein destabilization GO:0031648 8.96 CREBBP CDKN2A
6 replicative senescence GO:0090399 8.62 TP53 CDKN2A

Molecular functions related to Bladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 9.26 TP53 CREBBP
2 RNA polymerase II transcription factor binding GO:0001085 9.16 TP53 CREBBP
3 transcription factor binding GO:0008134 9.13 TP53 CREBBP CDKN2A
4 disordered domain specific binding GO:0097718 8.62 TP53 CDKN2A

Sources for Bladder Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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