MCID: BLD047
MIFTS: 30

Bladder Squamous Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases, Skin diseases

Aliases & Classifications for Bladder Squamous Cell Carcinoma

MalaCards integrated aliases for Bladder Squamous Cell Carcinoma:

Name: Bladder Squamous Cell Carcinoma 12 15 17 71
Epidermoid Carcinoma of the Urinary Bladder 12
Squamous Cell Carcinoma of Bladder 12
Carcinoma Squamous Cell Bladder 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3742
NCIt 49 C4031
UMLS 71 C0279681

Summaries for Bladder Squamous Cell Carcinoma

Disease Ontology : 12 A carcinoma of bladder that is manifested in squamous cells of the bladder.

MalaCards based summary : Bladder Squamous Cell Carcinoma, also known as epidermoid carcinoma of the urinary bladder, is related to squamous cell carcinoma and transitional cell carcinoma, and has symptoms including dysuria An important gene associated with Bladder Squamous Cell Carcinoma is S100A7 (S100 Calcium Binding Protein A7), and among its related pathways/superpathways is Oncogene Induced Senescence. The drugs Epirubicin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and skin.

Related Diseases for Bladder Squamous Cell Carcinoma

Graphical network of the top 20 diseases related to Bladder Squamous Cell Carcinoma:



Diseases related to Bladder Squamous Cell Carcinoma

Symptoms & Phenotypes for Bladder Squamous Cell Carcinoma

UMLS symptoms related to Bladder Squamous Cell Carcinoma:


dysuria

Drugs & Therapeutics for Bladder Squamous Cell Carcinoma

Drugs for Bladder Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epirubicin Approved Phase 3 56420-45-2 41867
2
Fluorouracil Approved Phase 3 51-21-8 3385
3
BCG vaccine Investigational Phase 3
4 Topoisomerase Inhibitors Phase 3
5 Immunologic Factors Phase 3
6 Anti-Infective Agents Phase 3
7 Antiviral Agents Phase 3
8 Vaccines Phase 3
9 Adjuvants, Immunologic Phase 3
10 interferons Phase 3
11 Interferon-alpha Phase 3
12 Anti-Bacterial Agents Phase 3
13 Alkylating Agents Phase 3
14 Mitomycins Phase 3
15 Antibiotics, Antitubercular Phase 3
16
leucovorin Approved Phase 2 58-05-9 6006 143
17
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
18
Gemcitabine Approved Phase 2 95058-81-4 60750
19
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
20 Piritrexim Investigational Phase 2 72732-56-0
21
Rubitecan Investigational Phase 2 91421-42-0
22
Camptothecin Experimental Phase 2 7689-03-4
23 Folic Acid Antagonists Phase 2
24 Vitamin B Complex Phase 2
25 Vitamin B9 Phase 2
26 Folate Phase 2
27 topoisomerase I inhibitors Phase 2
28 Immunosuppressive Agents Phase 2
29 Antimetabolites Phase 2
30 Antimitotic Agents Phase 2
31 Albumin-Bound Paclitaxel Phase 2
32 Antibodies, Monoclonal Phase 1
33 Interleukin-2 Phase 1
34 Antibodies Phase 1
35 Immunoglobulins Phase 1
36 Mitogens Phase 1
37
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
38
Dimenhydrinate Approved 523-87-5 441281
39
Ethanol Approved 64-17-5 702
40 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HYMN: A Randomized Controlled Phase III Trial Comparing Hyperthermia Plus Mitomycin to a Second Course of Bacillus Calmette-Guerin or Standard Therapy in Patients With Recurrence of Non-Muscle Invasive Bladder Cancer Following Induction or Maintenance Bacillus Calmette-Guerin Therapy Unknown status NCT01094964 Phase 3 epirubicin hydrochloride;mitomycin C
2 2X2 Factorial Randomized Phase III Study Comparing Standard Versus Reduced Volume Radiotherapy With and Without Synchronous Chemotherapy in Muscle Invasive Bladder Cancer Completed NCT00024349 Phase 3 fluorouracil;mitomycin C
3 Bladder Cancer: Open Versus Laparoscopic or Robotic Cystectomy. A Study to Determine the Feasibility of Randomization to Open Versus Minimal Access Cystectomy in Patients With Bladder Cancer. Unknown status NCT01196403 Phase 2
4 PHASE II STUDY OF PIRITREXIM IN ADVANCED CARCINOMA OF THE UROTHELIUM Completed NCT00002914 Phase 2 piritrexim
5 Open Label Phase II Study on RFS 2000 (9-Nitro-Camptothecin, 9-NC) Administered as a "5 Days On-2 Days Off" Oral Treatment in Advanced/Metastatic Urothelial Tract Tumors Completed NCT00006026 Phase 2 rubitecan
6 Protocol for Assessment of Gemcitabine and Paclitaxel for Metastatic Urothelial Cancer in Patients Aged 70 Years or Older (and in a Cohort of Patients Younger Than 60 Years) Terminated NCT00022633 Phase 2 gemcitabine hydrochloride;paclitaxel
7 Image Guided Dose Escalated Adaptive Bladder Radiotherapy Unknown status NCT01124682 Phase 1
8 Phase I Dose-Escalation Study of the Pharmacokinetic, Safety, Tolerability, and Biologic Activity of huKS-IL-2 Administered Daily as a 1-Hour Intravenous Infusion for Five Consecutive Days for Treatment of Refractory Epithelial Cancer Completed NCT00016237 Phase 1
9 VISTA (VIrus Specific T Cells and Adenovirus): A First in Human Phase I Trial of Binary Oncolytic Adenovirus in Combination With HER2-Specific CAR VST Cells in Patients With Advanced HER2 Positive Solid Tumors Not yet recruiting NCT03740256 Phase 1
10 Study of The Examination of Sentinel Lymph Nodes for OX-40 Expression in Patients With Cancer Completed NCT00900302

Search NIH Clinical Center for Bladder Squamous Cell Carcinoma

Genetic Tests for Bladder Squamous Cell Carcinoma

Anatomical Context for Bladder Squamous Cell Carcinoma

MalaCards organs/tissues related to Bladder Squamous Cell Carcinoma:

40
Lung, Lymph Node, Skin, T Cells, Colon, B Cells

Publications for Bladder Squamous Cell Carcinoma

Articles related to Bladder Squamous Cell Carcinoma:

(show top 50) (show all 61)
# Title Authors PMID Year
1
Psoriasin (S100A7): a putative urinary marker for the follow-up of patients with bladder squamous cell carcinomas. 54 61
10197442 1999
2
Bladder squamous cell carcinomas express psoriasin and externalize it to the urine. 54 61
8618345 1996
3
Dose-escalation of radiation may improve outcomes of squamous cell carcinoma of bladder. 61
31886420 2020
4
Reply to: Dose-escalation of radiation may improve outcomes of squamous cell carcinoma of bladder. 61
31886421 2020
5
Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets. 61
30927206 2019
6
Lung Involvement in Chronic Schistosomiasis with Bladder Squamous Cell Carcinoma. 61
30460893 2018
7
Frequent PD-L1 Protein Expression and Molecular Correlates in Urinary Bladder Squamous Cell Carcinoma. 61
29980330 2018
8
Bladder squamous cell cancer accompanied by Trousseau's syndrome: a case report. 61
29636934 2018
9
TWIST2 EXPRESSIONS IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE URINARY BLADDER SHOWED DOWN REGULATION CORRELATED WITH GOOD SURVIVAL AND LOW INCIDENCE OF DISTANT METASTASIS. 61
30157337 2017
10
[Urinary schistosomiasis and cancer]. 61
28185084 2017
11
Risk factors for development of primary bladder squamous cell carcinoma. 61
27869492 2017
12
Alterations of mTOR and PTEN protein expression in schistosomal squamous cell carcinoma and urothelial carcinoma. 61
26916953 2016
13
High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder. 61
26965579 2016
14
Bladder squamous cell carcinoma in pregnancy. 61
26467844 2016
15
Primary squamous cell carcinoma of bladder exstrophy in an adult. 61
25878418 2015
16
Small cell carcinoma of the bladder associated with schistosomiasis: a case report. 61
25803993 2014
17
Vesicoenteric fistula due to bladder squamous cell carcinoma. 61
25045451 2014
18
Squamous cell carcinogenesis and squamous cell carcinoma of the urinary bladder: a contemporary review with focus on nonbilharzial squamous cell carcinoma. 61
23433891 2014
19
Novel markers of squamous differentiation in the urinary bladder. 61
23806524 2013
20
Biopsy case mix and diagnostic yield at a Malawian central hospital. 61
24358421 2013
21
Cloacal anomaly with bladder tumor. 61
23956519 2013
22
c-KIT positive schistosomal urinary bladder carcinoma are frequent but lack KIT gene mutations. 61
23534715 2013
23
p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma. 61
22684221 2012
24
Expression of calcium binding protein S100 A7 (psoriasin) in laryngeal carcinoma. 61
22936138 2012
25
Radiation treatment of bladder squamous cell carcinoma in a patient with spina bifida: A case report. 61
22709884 2012
26
Urinary schistosomiasis with simultaneous bladder squamous cell carcinoma and transitional cell carcinoma. 61
23109968 2012
27
Prognostic value of cyclooxygenase-2 expression in squamous cell carcinoma of the bladder. 61
21255800 2011
28
Squamous cell carcinoma of the bladder associated with chronic irritation related to a migrated intrauterine device. 61
20367452 2010
29
Enterovesical fistula caused by a bladder squamous cell carcinoma. 61
19725163 2009
30
Tumourigenic effect of Schistosoma haematobium total antigen in mammalian cells. 61
19659903 2009
31
Urothelial carcinoma versus squamous cell carcinoma of bladder: is survival different with stage adjustment? 61
19193403 2009
32
A panel of angiogenic factors for early bladder cancer detection: enzyme immunoassay and Western blot. 61
19185322 2009
33
Treatment of locally advanced and metastatic bladder cancer. 61
19468366 2008
34
New developments in first- and second-line chemotherapy for transitional cell, squamous cell and adenocarcinoma of the bladder. 61
17762632 2007
35
Rapid diagnosis and follow up of bladder cancer patients using urinary high molecular weight cytokeratins. 61
16705457 2006
36
Survival from rare cancer in adults: a population-based study. 61
16455477 2006
37
[Squamous cell carcinoma of bladder producing granulocyte colony-stimulating factor (G-CSF): a case report]. 61
15773367 2005
38
Bladder squamous cell carcinoma. 61
15143234 2004
39
Muscle invasive schistosomal squamous cell carcinoma of the urinary bladder: frequency and prognostic significance of p53, BCL-2, HER2/neu, and proliferation (MIB-1). 61
14991535 2004
40
Bladder squamous cell carcinoma biomarkers derived from proteomics. 61
10892722 2000
41
Squamous cell carcinoma of the bladder: a ten-year retrospective study. 61
10074727 1998
42
Enhanced tumorigenicity of rat bladder squamous cell carcinoma cells after abrogation of gap junctional intercellular communication. 61
9685850 1998
43
Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation. 61
9515818 1998
44
Squamous cell carcinoma of bladder. 61
9146594 1997
45
Human papillomavirus and schistosomiasis associated bladder cancer. 61
9292149 1997
46
Expression of glutathione S-transferase activity and glutathione content in squamous cell carcinoma of bladder associated with schistosomiasis in a population in Egypt. 61
9060083 1997
47
[Epidermoid carcinoma of the bladder. Apropos of 14 cases]. 61
9412343 1997
48
Human papillomavirus in cyclophosphamide and diverticulum-associated squamous cell carcinoma of urinary bladder: a case report. 61
8705886 1996
49
Bladder squamous cell carcinoma with human papilloma virus type 6 [HPV 6]. 61
8749958 1995
50
UNME/K1: an IgG2a monoclonal antibody specific to cytokeratin of human urinary bladder squamous cell carcinoma. 61
1712997 1991

Variations for Bladder Squamous Cell Carcinoma

Expression for Bladder Squamous Cell Carcinoma

Search GEO for disease gene expression data for Bladder Squamous Cell Carcinoma.

Pathways for Bladder Squamous Cell Carcinoma

Pathways related to Bladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 MAPK1 CDKN2A

GO Terms for Bladder Squamous Cell Carcinoma

Molecular functions related to Bladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 8.8 NOMO3 NOMO2 CLEC1B

Sources for Bladder Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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