MCID: BLD049
MIFTS: 34

Bladder Transitional Cell Papilloma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Bladder Transitional Cell Papilloma

MalaCards integrated aliases for Bladder Transitional Cell Papilloma:

Name: Bladder Transitional Cell Papilloma 12 15
Bladder Papilloma 12 71
Transitional Cell Papilloma of Bladder 12
Urinary Bladder Urothelial Papilloma 12
Bladder Urothelial Papilloma 71
Urothelial Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6933
NCIt 49 C3842 C39858
SNOMED-CT 67 45083001
UMLS 71 C0235754 C1384678

Summaries for Bladder Transitional Cell Papilloma

MalaCards based summary : Bladder Transitional Cell Papilloma, also known as bladder papilloma, is related to non-invasive bladder papillary urothelial neoplasm and papillary transitional carcinoma. An important gene associated with Bladder Transitional Cell Papilloma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and TNFR1 Pathway. Affiliated tissues include prostate, lung and skin, and related phenotypes are cellular and embryo

Related Diseases for Bladder Transitional Cell Papilloma

Diseases related to Bladder Transitional Cell Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 non-invasive bladder papillary urothelial neoplasm 30.2 TP53 KRT20 FGFR3
2 papillary transitional carcinoma 30.1 TP53 KRT20
3 papilloma 30.0 TP53 KRT20 FGFR3 CDKN1A
4 urinary tract papillary transitional cell benign neoplasm 29.2 TP53 KRT20 HMBS FGFR3 CCN6 CCN5
5 bladder urothelial carcinoma 29.1 TP53 KRT20 FGFR3 BIRC5
6 transitional cell carcinoma 28.9 TP53 KRT20 FGFR3 CDKN1A BIRC5
7 ureter urothelial papilloma 12.4
8 urethral urothelial papilloma 12.4
9 renal pelvis urothelial papilloma 12.4
10 actinic cheilitis 10.4 TP53 CDKN1A
11 suppressor of tumorigenicity 3 10.4 TP53 CDKN1A
12 vulvar intraepithelial neoplasia 10.4 TP53 BIRC5
13 invasive bladder transitional cell carcinoma 10.4 TP53 CDKN1A
14 squamous cell papilloma 10.3
15 adult malignant schwannoma 10.3 TP53 BIRC5
16 lip cancer 10.3 TP53 CDKN1A
17 pectus excavatum 10.3 TP53 FGFR3
18 keratocystic odontogenic tumor 10.2 TP53 BIRC5
19 uterine adnexa cancer 10.2 TP53 BIRC5
20 serous cystadenocarcinoma 10.1 TP53 CDKN1A BIRC5
21 cystadenocarcinoma 10.1 TP53 CDKN1A BIRC5
22 intratubular embryonal carcinoma 10.1 TP53 KRT20
23 inflammatory myofibroblastic tumor 10.1 TP53 CDKN1A BIRC5
24 eccrine sweat gland cancer 10.1 TP53 KRT20
25 glandular cystitis 10.1 TP53 KRT20
26 chondromyxoid fibroma 10.1 FGFR3 CDKN1A
27 cheilitis 10.1 TP53 FGFR3 CDKN1A
28 testicular germ cell tumor 10.1 TP53 FGFR3 CDKN1A
29 cystitis 10.1
30 in situ carcinoma 10.1
31 appendix disease 10.1 TP53 KRT20
32 prostate neuroendocrine neoplasm 10.1 TP53 KRT20
33 appendix cancer 10.1 TP53 KRT20
34 hepatoblastoma 10.1 TP53 CYCS BIRC5
35 gastric diffuse adenocarcinoma 10.1 TP53 KRT20
36 bladder clear cell adenocarcinoma 10.1 TP53 KRT20
37 osteochondroma 10.0 FGFR3 CDKN1A
38 arthropathy, progressive pseudorheumatoid, of childhood 10.0 CCN6 CCN1
39 clear cell basal cell carcinoma 10.0 TP53 KRT20
40 ovarian benign neoplasm 10.0 TP53 KRT20
41 bladder cancer 10.0
42 conn's syndrome 10.0
43 inverted papilloma 10.0
44 skin papilloma 10.0 TP53 CDKN1A
45 urethra clear cell adenocarcinoma 10.0 TP53 KRT20
46 ataxia-telangiectasia 10.0 TP53 PARP1 CDKN1A
47 prostatic hyperplasia, benign 10.0
48 adenoid cystic carcinoma 10.0
49 prostatic adenoma 10.0
50 cystitis cystica 10.0

Graphical network of the top 20 diseases related to Bladder Transitional Cell Papilloma:



Diseases related to Bladder Transitional Cell Papilloma

Symptoms & Phenotypes for Bladder Transitional Cell Papilloma

MGI Mouse Phenotypes related to Bladder Transitional Cell Papilloma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 BID BIRC5 CASP2 CCN1 CDKN1A CYCS
2 embryo MP:0005380 9.8 BIRC5 CCN1 CDKN1A CYCS HMBS PARP1
3 endocrine/exocrine gland MP:0005379 9.7 BID BIRC5 CASP2 CCN6 CDKN1A CYCS
4 hearing/vestibular/ear MP:0005377 9.35 CCN5 CDKN1A FGFR3 PARP1 TP53
5 mortality/aging MP:0010768 9.32 BID BIRC5 CASP2 CCN1 CDKN1A CYCS

Drugs & Therapeutics for Bladder Transitional Cell Papilloma

Search Clinical Trials , NIH Clinical Center for Bladder Transitional Cell Papilloma

Genetic Tests for Bladder Transitional Cell Papilloma

Anatomical Context for Bladder Transitional Cell Papilloma

MalaCards organs/tissues related to Bladder Transitional Cell Papilloma:

40
Prostate, Lung, Skin, Colon, Breast, Appendix, Testes

Publications for Bladder Transitional Cell Papilloma

Articles related to Bladder Transitional Cell Papilloma:

(show top 50) (show all 78)
# Title Authors PMID Year
1
Proteomic characterization of arsenic and cadmium exposure in bladder cells. 61
31499585 2019
2
Effects of benzo[a]pyrene, aromatic amines, and a combination of both on CYP1A1 activities in RT-4 human bladder papilloma cells. 61
27924717 2016
3
[Isolated tricuspid valve infective endocarditis in a patient with a urological history]. 61
24868899 2014
4
Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion. 61
24312263 2013
5
Bladder papilloma in a 9-year-old girl: a case report. 61
22555331 2012
6
Toxicology and carcinogenesis studies of pulegone (CAS No. 89-82-7) in F344/N rats and B6C3F1 mice (gavage studies). 61
21921962 2011
7
A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species. 61
20669221 2011
8
Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. 61
18172282 2008
9
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. 61
16777994 2006
10
Elevated prostaglandin E2 level via cPLA2--COX-2--mPGES-1 pathway involved in bladder carcinogenesis induced by terephthalic acid-calculi in Wistar rats. 61
16621493 2006
11
Bladder papilloma in a 12-year-old girl. 61
18947558 2005
12
Glucose transporter-1 expression in urothelial papilloma of the bladder. 61
15812216 2005
13
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. 61
14651997 2003
14
Postoperative course after papilloma resection: effects of written disclosure of the experience in subjects with different alexithymia levels. 61
12764222 2003
15
Surgical management and genotype/phenotype correlations in WT1 gene-related diseases (Drash, Frasier syndromes). 61
12592634 2003
16
Urinary bladder transitional cell papilloma in a shorthorn heifer. 61
11062838 2000
17
[Report of 2 new cases of bladder inverted papilloma, one with them complicated with acute urinary obstruction]. 61
10965580 2000
18
[Study of the synergy of microwave hyperthermia/intravesical chemotherapy in the prevention of recurrences of superficial tumors of the bladder]. 61
10212955 1999
19
Intraductal papillary carcinoma of the parotid gland with low malignancy. 61
10337664 1999
20
Angiogenesis is an early event in the development of chemically induced skin tumors. 61
9886564 1998
21
[A case from practice (359). 1. Gynecomastia 2. Status following right-sided nephrectomy in renal tuberculosis 3. Recurrent microhematuria in bladder papilloma]. 61
8966449 1996
22
NTP Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CAS No. 81-49-2) in F344/N Rats and B6C3F1 Mice (Feed Studies). 61
12692653 1996
23
[Inverted bladder papilloma. Our contribution (7 cases)]. 61
7976716 1994
24
Human müllerian inhibiting substance inhibits tumor growth in vitro and in vivo. 61
2009529 1991
25
[A case of sigmoidovesical and ileovesical fistula with bladder papilloma complicating colonic diverticulitis]. 61
3287852 1988
26
[Follow-up of patients with microhematuria]. 61
3687028 1987
27
The effect of cell extracts of urological tumours on adenovirus mutants. 61
2444045 1987
28
Study of cytotoxicity against adenovirally transformed cells in patients with tumours of the urinary tract. 61
3721766 1986
29
[Papilloma of the bladder in childhood. Description of a case]. 61
3725602 1986
30
Cytology of bladder papilloma. 61
3863430 1985
31
Effect of levamisol on cellular and humoral immune reactivity and on recurrences in patients with bladder papilloma. 61
3835174 1985
32
Cell surface antigens of human bladder cancer defined by mouse monoclonal antibodies. 61
6364135 1984
33
[Papilloma of the gallbladder]. 61
6395977 1983
34
[Bladder papilloma. Treatment with interferon, sodium butyrate and isoprinosine]. 61
6190163 1983
35
[A very unusual tumor: inverted papilloma of the bladder]. 61
6655278 1983
36
Association of depressed mixed lymphocyte reactivity with the development of bladder carcinoma in patients with papillomas. 61
6217888 1983
37
[Clinical significance of inverted bladder papilloma]. 61
7129907 1982
38
Characterization of bladder papilloma by two-parameter DNA-RNA flow cytometry. 61
6174212 1982
39
Systemic IFN-alpha treatment of multiple bladder papilloma grade I or II patients: pilot study. 61
7130757 1982
40
Bladder papilloma in young patients. 61
7062886 1982
41
[Thrombopenia caused by heparin. Review of the literature apropos of a personal case]. 61
7142830 1982
42
Bladder papilloma: therapeutic and cost effect of outpatient department management. 61
6792764 1981
43
Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. 61
7248968 1981
44
[Echotomographic pattern of the gall bladder papilloma (author's transl)]. 61
7268071 1981
45
[Urinary bladder papilloma as a cause of monstrous hydronephrosis]. 61
7282129 1981
46
Urinary proteins as biological markers: bladder cancer diagnosis versus urinary tract infection. 61
6777507 1980
47
Inverted papilloma of the urinary bladder: ultrastructural and immunologic studies. 61
7388768 1980
48
[Adjuvant thio-tepa in the treatment of bladder papilloma. A prospective randomized study]. 61
6773198 1980
49
[Inverted bladder papilloma. Apropos of a case report]. 61
517335 1979
50
Qualitative analysis of proteinuria associated with bladder cancer. 61
87388 1979

Variations for Bladder Transitional Cell Papilloma

Expression for Bladder Transitional Cell Papilloma

Search GEO for disease gene expression data for Bladder Transitional Cell Papilloma.

Pathways for Bladder Transitional Cell Papilloma

Pathways related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 TP53 CYCS CDKN1A BIRC5 BID
2
Show member pathways
12.79 TP53 PARP1 CYCS CDKN1A CASP2 BID
3
Show member pathways
12.77 TP53 CYCS CDKN1A CASP2 BIRC5 BID
4
Show member pathways
12.66 TP53 CYCS CDKN1A BID
5 12.61 TP53 FGFR3 CYCS CDKN1A BIRC5 BID
6
Show member pathways
12.53 PARP1 CYCS CASP2 BID
7
Show member pathways
12.34 TP53 PARP1 CYCS CDKN1A CASP2 BID
8
Show member pathways
12.25 TP53 CYCS CDKN1A BID
9
Show member pathways
12.2 TP53 PARP1 CYCS CDKN1A CASP2 BIRC5
10
Show member pathways
12.06 PARP1 CYCS CASP2 BID
11 12.04 TP53 CDKN1A BIRC5
12 11.93 TP53 CDKN1A BID
13
Show member pathways
11.91 TP53 PARP1 CYCS BID
14
Show member pathways
11.9 TP53 CYCS BID
15 11.86 TP53 CDKN1A BIRC5
16
Show member pathways
11.85 TP53 CYCS BID
17 11.82 PARP1 CYCS CASP2 BIRC5 BID
18
Show member pathways
11.78 TP53 CASP2 BIRC5 BID
19 11.74 TP53 CYCS CDKN1A
20 11.63 TP53 FGFR3 CDKN1A
21
Show member pathways
11.61 TP53 CDKN1A CASP2 BID
22
Show member pathways
11.54 CYCS CASP2 BIRC5 BID
23 11.46 TP53 CDKN1A BID
24 11.45 TP53 CDKN1A BIRC5
25
Show member pathways
11.42 PARP1 CYCS BID
26 11.27 TP53 BIRC5 BID
27 11.01 PARP1 CYCS
28
Show member pathways
10.95 TP53 CDKN1A BID
29 10.88 TP53 CYCS CDKN1A BIRC5 BID
30 10.69 TP53 CDKN1A
31
Show member pathways
10.5 TP53 CDKN1A
32 10.15 PARP1 CYCS

GO Terms for Bladder Transitional Cell Papilloma

Cellular components related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.1 TP53 PARP1 CYCS CCN6 CASP2 BID

Biological processes related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.84 TP53 CCN1 CASP2 BID
2 regulation of apoptotic process GO:0042981 9.73 TP53 CASP2 BIRC5 BID
3 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.59 TP53 CDKN1A
4 response to gamma radiation GO:0010332 9.58 TP53 PARP1
5 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.58 TP53 BID
6 negative regulation of cell death GO:0060548 9.58 CCN6 CCN5 CCN1
7 release of cytochrome c from mitochondria GO:0001836 9.57 TP53 BID
8 response to X-ray GO:0010165 9.56 TP53 CDKN1A
9 mitotic cell cycle arrest GO:0071850 9.55 TP53 CDKN1A
10 response to hyperoxia GO:0055093 9.52 TP53 CDKN1A
11 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.51 TP53 CDKN1A
12 replicative senescence GO:0090399 9.49 TP53 CDKN1A
13 positive regulation of protein oligomerization GO:0032461 9.48 TP53 BID
14 positive regulation of phospholipase activity GO:0010518 9.46 FGFR3 CCN1
15 negative regulation of apoptotic process GO:0043066 9.43 TP53 CDKN1A CCN1 CASP2 BIRC5 BID
16 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 9.37 TP53 BID
17 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.33 TP53 CDKN1A CASP2
18 signal transduction by p53 class mediator GO:0072331 9.32 TP53 CDKN1A
19 mitochondrial DNA repair GO:0043504 9.26 TP53 PARP1
20 apoptotic process GO:0006915 9.23 TP53 PARP1 KRT20 FGFR3 CYCS CASP2

Molecular functions related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.43 CCN6 CCN5 CCN1
2 integrin binding GO:0005178 9.33 CCN6 CCN5 CCN1
3 enzyme binding GO:0019899 9.26 TP53 PARP1 CASP2 BIRC5
4 insulin-like growth factor binding GO:0005520 8.8 CCN6 CCN5 CCN1

Sources for Bladder Transitional Cell Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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