MCID: BLD049
MIFTS: 35

Bladder Transitional Cell Papilloma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Bladder Transitional Cell Papilloma

MalaCards integrated aliases for Bladder Transitional Cell Papilloma:

Name: Bladder Transitional Cell Papilloma 12 15
Bladder Papilloma 12 72
Transitional Cell Papilloma of Bladder 12
Urinary Bladder Urothelial Papilloma 12
Bladder Urothelial Papilloma 72
Urothelial Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6933
NCIt 50 C3842 C39858
SNOMED-CT 68 45083001
UMLS 72 C0235754 C1384678

Summaries for Bladder Transitional Cell Papilloma

MalaCards based summary : Bladder Transitional Cell Papilloma, also known as bladder papilloma, is related to urinary tract papillary transitional cell benign neoplasm and non-invasive bladder papillary urothelial neoplasm. An important gene associated with Bladder Transitional Cell Papilloma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Gene Expression and Human cytomegalovirus infection. Affiliated tissues include skin, colon and prostate, and related phenotypes are Increased Nanog expression and Increased Nanog expression

Related Diseases for Bladder Transitional Cell Papilloma

Diseases related to Bladder Transitional Cell Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 urinary tract papillary transitional cell benign neoplasm 32.4 TP53 FGFR3
2 non-invasive bladder papillary urothelial neoplasm 30.8 TP53 FGFR3
3 papilloma 30.3 TP53 FGFR3 CDKN1A
4 bladder cancer 29.1 TP53 FGFR3 CDKN1A BIRC5
5 ureter urothelial papilloma 12.4
6 urethral urothelial papilloma 12.4
7 renal pelvis urothelial papilloma 12.4
8 squamous cell papilloma 10.4
9 vulvar intraepithelial neoplasia 10.3 TP53 BIRC5
10 cervical carcinosarcoma 10.3 TP53 BIRC5
11 actinic cheilitis 10.3 TP53 CDKN1A
12 invasive bladder transitional cell carcinoma 10.3 TP53 CDKN1A
13 atypical follicular adenoma 10.3 TP53 CDKN1A
14 lip cancer 10.3 TP53 CDKN1A
15 keratocystic odontogenic tumor 10.3 TP53 BIRC5
16 bladder papillary transitional cell neoplasm 10.2 TP53 FGFR3
17 suppressor of tumorigenicity 3 10.2 TP53 CDKN1A
18 malignant mesenchymoma 10.2 TP53 CDKN1A
19 cervix carcinoma 10.1 TP53 FGFR3
20 keratoacanthoma 10.1 TP53 CDKN1A
21 adenosquamous lung carcinoma 10.1 FGFR3 BIRC5
22 giant cell glioblastoma 10.1 TP53 FGFR3
23 cystitis 10.1
24 in situ carcinoma 10.1
25 retinal cancer 10.1 TP53 CDKN1A
26 cervical adenocarcinoma 10.1 TP53 CDKN1A
27 chondromyxoid fibroma 10.0 FGFR3 CDKN1A
28 osteochondroma 10.0 FGFR3 CDKN1A
29 ocular cancer 10.0 TP53 CDKN1A
30 conn's syndrome 10.0
31 inverted papilloma 10.0
32 skin melanoma 10.0 TP53 CDKN1A
33 autonomic nervous system neoplasm 10.0 TP53 CYCS
34 ovarian serous cystadenocarcinoma 10.0 TP53 BIRC5
35 prostatic hyperplasia, benign 10.0
36 adenoid cystic carcinoma 10.0
37 prostatic adenoma 10.0
38 papillary transitional carcinoma 10.0
39 cystitis cystica 10.0
40 bladder disease 10.0 TP53 FGFR3
41 adenocarcinoma 9.9 TP53 FGFR3 BIRC5
42 ureterocele 9.9
43 hydronephrosis 9.9
44 prostatic hypertrophy 9.9
45 sarcoma 9.9
46 infant gynecomastia 9.9
47 gynecomastia 9.9
48 transitional papilloma 9.9
49 transitional cell carcinoma 9.9
50 papillary carcinoma 9.9

Graphical network of the top 20 diseases related to Bladder Transitional Cell Papilloma:



Diseases related to Bladder Transitional Cell Papilloma

Symptoms & Phenotypes for Bladder Transitional Cell Papilloma

GenomeRNAi Phenotypes related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.1 BIRC5 CASP2 FGFR3
2 Increased Nanog expression GR00371-A-3 9.1 BIRC5
3 Increased Nanog expression GR00371-A-5 9.1 BIRC5 CASP2

MGI Mouse Phenotypes related to Bladder Transitional Cell Papilloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 BIRC5 CASP2 CDKN1A CYCS FGFR3 PARP1
2 hematopoietic system MP:0005397 9.87 BIRC5 CASP2 CDKN1A CYCS FGFR3 PARP1
3 embryo MP:0005380 9.83 BIRC5 CDKN1A CYCS PARP1 TP53
4 endocrine/exocrine gland MP:0005379 9.8 BIRC5 CASP2 CDKN1A CYCS TP53
5 immune system MP:0005387 9.8 BIRC5 CASP2 CDKN1A CYCS FGFR3 PARP1
6 craniofacial MP:0005382 9.76 CDKN1A CYCS FGFR3 TP53
7 mortality/aging MP:0010768 9.7 BIRC5 CASP2 CDKN1A CYCS FGFR3 PARP1
8 hearing/vestibular/ear MP:0005377 9.67 CDKN1A FGFR3 PARP1 TP53
9 nervous system MP:0003631 9.43 CASP2 CDKN1A CYCS FGFR3 PARP1 TP53
10 reproductive system MP:0005389 9.02 CASP2 CDKN1A FGFR3 PARP1 TP53

Drugs & Therapeutics for Bladder Transitional Cell Papilloma

Search Clinical Trials , NIH Clinical Center for Bladder Transitional Cell Papilloma

Genetic Tests for Bladder Transitional Cell Papilloma

Anatomical Context for Bladder Transitional Cell Papilloma

MalaCards organs/tissues related to Bladder Transitional Cell Papilloma:

41
Skin, Colon, Prostate, Lung, Testes

Publications for Bladder Transitional Cell Papilloma

Articles related to Bladder Transitional Cell Papilloma:

(show top 50) (show all 77)
# Title Authors PMID Year
1
Effects of benzo[a]pyrene, aromatic amines, and a combination of both on CYP1A1 activities in RT-4 human bladder papilloma cells. 38
27924717 2016
2
[Isolated tricuspid valve infective endocarditis in a patient with a urological history]. 38
24868899 2014
3
Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion. 38
24312263 2013
4
Bladder papilloma in a 9-year-old girl: a case report. 38
22555331 2012
5
Toxicology and carcinogenesis studies of pulegone (CAS No. 89-82-7) in F344/N rats and B6C3F1 mice (gavage studies). 38
21921962 2011
6
A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species. 38
20669221 2011
7
Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. 38
18172282 2008
8
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. 38
16777994 2006
9
Elevated prostaglandin E2 level via cPLA2--COX-2--mPGES-1 pathway involved in bladder carcinogenesis induced by terephthalic acid-calculi in Wistar rats. 38
16621493 2006
10
Bladder papilloma in a 12-year-old girl. 38
18947558 2005
11
Glucose transporter-1 expression in urothelial papilloma of the bladder. 38
15812216 2005
12
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. 38
14651997 2003
13
Postoperative course after papilloma resection: effects of written disclosure of the experience in subjects with different alexithymia levels. 38
12764222 2003
14
Surgical management and genotype/phenotype correlations in WT1 gene-related diseases (Drash, Frasier syndromes). 38
12592634 2003
15
Urinary bladder transitional cell papilloma in a shorthorn heifer. 38
11062838 2000
16
[Report of 2 new cases of bladder inverted papilloma, one with them complicated with acute urinary obstruction]. 38
10965580 2000
17
[Study of the synergy of microwave hyperthermia/intravesical chemotherapy in the prevention of recurrences of superficial tumors of the bladder]. 38
10212955 1999
18
Intraductal papillary carcinoma of the parotid gland with low malignancy. 38
10337664 1999
19
Angiogenesis is an early event in the development of chemically induced skin tumors. 38
9886564 1998
20
[A case from practice (359). 1. Gynecomastia 2. Status following right-sided nephrectomy in renal tuberculosis 3. Recurrent microhematuria in bladder papilloma]. 38
8966449 1996
21
NTP Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CAS No. 81-49-2) in F344/N Rats and B6C3F1 Mice (Feed Studies). 38
12692653 1996
22
[Inverted bladder papilloma. Our contribution (7 cases)]. 38
7976716 1994
23
Human müllerian inhibiting substance inhibits tumor growth in vitro and in vivo. 38
2009529 1991
24
[A case of sigmoidovesical and ileovesical fistula with bladder papilloma complicating colonic diverticulitis]. 38
3287852 1988
25
[Follow-up of patients with microhematuria]. 38
3687028 1987
26
The effect of cell extracts of urological tumours on adenovirus mutants. 38
2444045 1987
27
Study of cytotoxicity against adenovirally transformed cells in patients with tumours of the urinary tract. 38
3721766 1986
28
[Papilloma of the bladder in childhood. Description of a case]. 38
3725602 1986
29
Cytology of bladder papilloma. 38
3863430 1985
30
Effect of levamisol on cellular and humoral immune reactivity and on recurrences in patients with bladder papilloma. 38
3835174 1985
31
Cell surface antigens of human bladder cancer defined by mouse monoclonal antibodies. 38
6364135 1984
32
[Papilloma of the gallbladder]. 38
6395977 1983
33
[Bladder papilloma. Treatment with interferon, sodium butyrate and isoprinosine]. 38
6190163 1983
34
[A very unusual tumor: inverted papilloma of the bladder]. 38
6655278 1983
35
Association of depressed mixed lymphocyte reactivity with the development of bladder carcinoma in patients with papillomas. 38
6217888 1983
36
[Clinical significance of inverted bladder papilloma]. 38
7129907 1982
37
Characterization of bladder papilloma by two-parameter DNA-RNA flow cytometry. 38
6174212 1982
38
Systemic IFN-alpha treatment of multiple bladder papilloma grade I or II patients: pilot study. 38
7130757 1982
39
Bladder papilloma in young patients. 38
7062886 1982
40
[Thrombopenia caused by heparin. Review of the literature apropos of a personal case]. 38
7142830 1982
41
Bladder papilloma: therapeutic and cost effect of outpatient department management. 38
6792764 1981
42
Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. 38
7248968 1981
43
[Echotomographic pattern of the gall bladder papilloma (author's transl)]. 38
7268071 1981
44
[Urinary bladder papilloma as a cause of monstrous hydronephrosis]. 38
7282129 1981
45
Urinary proteins as biological markers: bladder cancer diagnosis versus urinary tract infection. 38
6777507 1980
46
Inverted papilloma of the urinary bladder: ultrastructural and immunologic studies. 38
7388768 1980
47
[Adjuvant thio-tepa in the treatment of bladder papilloma. A prospective randomized study]. 38
6773198 1980
48
[Inverted bladder papilloma. Apropos of a case report]. 38
517335 1979
49
Qualitative analysis of proteinuria associated with bladder cancer. 38
87388 1979
50
Recurrent bladder papilloma in a child with Cushing's syndrome. Case report. 38
482873 1979

Variations for Bladder Transitional Cell Papilloma

Expression for Bladder Transitional Cell Papilloma

Search GEO for disease gene expression data for Bladder Transitional Cell Papilloma.

Pathways for Bladder Transitional Cell Papilloma

Pathways related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 TP53 PARP1 CYCS CDKN1A CASP2 BIRC5
2
Show member pathways
12.73 TP53 CYCS CDKN1A BIRC5
3
Show member pathways
12.64 TP53 PARP1 CYCS CDKN1A CASP2
4
Show member pathways
12.63 TP53 CYCS CDKN1A BIRC5
5
Show member pathways
12.59 TP53 CYCS CDKN1A CASP2 BIRC5
6
Show member pathways
12.44 PARP1 CYCS CASP2
7
Show member pathways
12.4 TP53 PARP1 BIRC5
8
Show member pathways
12.39 TP53 CDKN1A BIRC5
9 12.38 TP53 FGFR3 CYCS CDKN1A BIRC5
10 12.34 TP53 FGFR3 CDKN1A
11
Show member pathways
12.21 TP53 CDKN1A BIRC5
12
Show member pathways
12.19 TP53 CYCS CDKN1A
13
Show member pathways
12.16 TP53 PARP1 CYCS CDKN1A CASP2
14
Show member pathways
12.07 PARP1 CYCS CASP2
15
Show member pathways
12.06 TP53 CDKN1A CASP2
16
Show member pathways
12.02 TP53 FGFR3 CDKN1A
17 11.99 TP53 CDKN1A BIRC5
18 11.95 TP53 FGFR3 CDKN1A
19
Show member pathways
11.94 CYCS CDKN1A CASP2
20 11.89 PARP1 CYCS CASP2 BIRC5
21
Show member pathways
11.85 TP53 PARP1 CYCS
22
Show member pathways
11.8 TP53 PARP1 CYCS CDKN1A CASP2 BIRC5
23 11.79 TP53 CDKN1A BIRC5
24
Show member pathways
11.75 TP53 CASP2 BIRC5
25 11.68 TP53 CYCS CDKN1A
26
Show member pathways
11.63 TP53 CDKN1A CASP2
27
Show member pathways
11.59 CYCS CASP2 BIRC5
28 11.54 TP53 FGFR3
29
Show member pathways
11.52 TP53 CYCS
30 11.52 TP53 FGFR3 CDKN1A
32 11.4 TP53 CDKN1A
33 11.39 TP53 CDKN1A
34
Show member pathways
11.37 PARP1 CYCS
35 11.34 TP53 CDKN1A
36 11.32 TP53 CDKN1A
37 11.29 TP53 CDKN1A BIRC5
38 11.26 TP53 CDKN1A
39 11.23 TP53 BIRC5
40 11.16 TP53 CDKN1A
41 11.14 TP53 BIRC5
42 11.12 TP53 PARP1 CYCS
43 11.12 TP53 CYCS CDKN1A BIRC5
44 10.99 PARP1 CYCS
45
Show member pathways
10.97 TP53 CDKN1A
46 10.65 TP53 CDKN1A
47 10.03 PARP1 CYCS

GO Terms for Bladder Transitional Cell Papilloma

Cellular components related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.17 TP53 PARP1 FGFR3 CYCS CDKN1A CASP2

Biological processes related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 TP53 CDKN1A BIRC5
2 regulation of apoptotic process GO:0042981 9.65 TP53 CASP2 BIRC5
3 Ras protein signal transduction GO:0007265 9.54 TP53 CDKN1A
4 cellular response to UV GO:0034644 9.52 TP53 PARP1
5 regulation of mitotic cell cycle GO:0007346 9.51 CDKN1A BIRC5
6 cellular response to ionizing radiation GO:0071479 9.46 TP53 CDKN1A
7 negative regulation of apoptotic process GO:0043066 9.46 TP53 CDKN1A CASP2 BIRC5
8 response to gamma radiation GO:0010332 9.43 TP53 PARP1
9 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.43 TP53 CDKN1A CASP2
10 positive regulation of reactive oxygen species metabolic process GO:2000379 9.4 TP53 CDKN1A
11 replicative senescence GO:0090399 9.37 TP53 CDKN1A
12 signal transduction by p53 class mediator GO:0072331 9.32 TP53 CDKN1A
13 apoptotic process GO:0006915 9.1 TP53 PARP1 FGFR3 CYCS CASP2 BIRC5
14 intrinsic apoptotic signaling pathway GO:0097193 8.96 TP53 CDKN1A

Molecular functions related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 TP53 PARP1 FGFR3 CASP2 BIRC5
2 enzyme binding GO:0019899 8.92 TP53 PARP1 CASP2 BIRC5

Sources for Bladder Transitional Cell Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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