MCID: BLD049
MIFTS: 32

Bladder Transitional Cell Papilloma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Bladder Transitional Cell Papilloma

MalaCards integrated aliases for Bladder Transitional Cell Papilloma:

Name: Bladder Transitional Cell Papilloma 12 15
Bladder Papilloma 12 71
Transitional Cell Papilloma of Bladder 12
Urinary Bladder Urothelial Papilloma 12
Bladder Urothelial Papilloma 71
Urothelial Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6933
NCIt 50 C3842 C39858
SNOMED-CT 67 189459005 45083001
UMLS 71 C0235754 C1384678

Summaries for Bladder Transitional Cell Papilloma

MalaCards based summary : Bladder Transitional Cell Papilloma, also known as bladder papilloma, is related to non-invasive bladder papillary urothelial neoplasm and papilloma. An important gene associated with Bladder Transitional Cell Papilloma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Gene Expression and Toll-like Receptor Signaling Pathway. Related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Bladder Transitional Cell Papilloma

Diseases related to Bladder Transitional Cell Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 non-invasive bladder papillary urothelial neoplasm 30.2 TP53 KRT20 FGFR3
2 papilloma 30.2 TP53 KRT20 FGFR3 CDKN1A
3 papillary transitional carcinoma 30.1 TP53 KRT20
4 urinary tract papillary transitional cell benign neoplasm 30.0 TP53 TERT KRT20 FGFR3 CCN6 CCN5
5 bladder urothelial carcinoma 29.7 TP53 KRT20 FGFR3
6 sarcoma 29.6 TP53 FGFR3 CYCS CDKN1A
7 rhabdomyosarcoma 29.5 TP53 FGFR3 CYCS CDKN1A
8 transitional cell carcinoma 29.1 TP53 KRT20 FGFR3 CDKN1A BIRC5
9 bladder cancer 29.1 TP53 TERT KRT20 FGFR3 CDKN1A BIRC5
10 ureter urothelial papilloma 11.4
11 urethral urothelial papilloma 11.3
12 renal pelvis urothelial papilloma 11.3
13 squamous cell papilloma 10.3
14 suppressor of tumorigenicity 3 10.3 TP53 CDKN1A
15 invasive bladder transitional cell carcinoma 10.3 TP53 CDKN1A
16 vulvar intraepithelial neoplasia 10.3 TP53 BIRC5
17 lip cancer 10.3 TP53 CDKN1A
18 adult malignant schwannoma 10.2 TP53 BIRC5
19 uterine adnexa cancer 10.2 TP53 BIRC5
20 high-grade astrocytoma 10.2 TP53 PARP1
21 keratocystic odontogenic tumor 10.2 TP53 BIRC5
22 childhood malignant schwannoma 10.2 TP53 BIRC5
23 skin papilloma 10.2 TP53 CDKN1A
24 intratubular embryonal carcinoma 10.2 TP53 KRT20
25 eccrine sweat gland cancer 10.2 TP53 KRT20
26 glandular cystitis 10.2 TP53 KRT20
27 bladder clear cell adenocarcinoma 10.2 TP53 KRT20
28 clear cell basal cell carcinoma 10.2 TP53 KRT20
29 urethral benign neoplasm 10.2 TP53 KRT20
30 appendix disease 10.2 TP53 KRT20
31 peritoneal serous adenocarcinoma 10.2 TP53 KRT20
32 appendix cancer 10.1 TP53 KRT20
33 acanthoma 10.1 TP53 FGFR3
34 chondromyxoid fibroma 10.1 FGFR3 CDKN1A
35 granulosa cell tumor of the ovary 10.1 TP53 TERT
36 mixed oligodendroglioma-astrocytoma 10.1 TP53 TERT
37 bile duct adenoma 10.1 TP53 KRT20
38 ovarian benign neoplasm 10.1 TP53 KRT20
39 intrahepatic bile duct adenoma 10.1 TP53 KRT20
40 osteochondroma 10.1 FGFR3 CDKN1A
41 dyskeratosis congenita autosomal recessive 10.1 TP53 TERT
42 serous cystadenocarcinoma 10.1 TP53 CDKN1A BIRC5
43 cystadenocarcinoma 10.1 TP53 CDKN1A BIRC5
44 inflammatory myofibroblastic tumor 10.1 TP53 CDKN1A BIRC5
45 borst-jadassohn intraepidermal carcinoma 10.1 TP53 KRT20
46 liver benign neoplasm 10.1 TP53 TERT
47 actinic cheilitis 10.1 TP53 FGFR3 CDKN1A
48 cheilitis 10.1 TP53 FGFR3 CDKN1A
49 duodenum cancer 10.1 TP53 KRT20
50 prostatic hypertrophy 10.1

Graphical network of the top 20 diseases related to Bladder Transitional Cell Papilloma:



Diseases related to Bladder Transitional Cell Papilloma

Symptoms & Phenotypes for Bladder Transitional Cell Papilloma

GenomeRNAi Phenotypes related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 BID BIRC5 CDKN1A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 BID BIRC5 CDKN1A TERT TP53
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.32 CDKN1A TP53

MGI Mouse Phenotypes related to Bladder Transitional Cell Papilloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 BID BIRC5 CASP2 CDKN1A CYCS FGFR3
2 endocrine/exocrine gland MP:0005379 9.92 BID BIRC5 CASP2 CCN6 CDKN1A CYCS
3 hematopoietic system MP:0005397 9.81 BID BIRC5 CASP2 CDKN1A CYCS FGFR3
4 hearing/vestibular/ear MP:0005377 9.65 CCN5 CDKN1A FGFR3 PARP1 TP53
5 immune system MP:0005387 9.61 BID BIRC5 CASP2 CDKN1A CYCS FGFR3
6 neoplasm MP:0002006 9.02 CCN6 CDKN1A FGFR3 TERT TP53

Drugs & Therapeutics for Bladder Transitional Cell Papilloma

Search Clinical Trials , NIH Clinical Center for Bladder Transitional Cell Papilloma

Genetic Tests for Bladder Transitional Cell Papilloma

Anatomical Context for Bladder Transitional Cell Papilloma

Publications for Bladder Transitional Cell Papilloma

Articles related to Bladder Transitional Cell Papilloma:

(show top 50) (show all 80)
# Title Authors PMID Year
1
[Intravesical Gemcitabine instillations following BCG failure and allergy to Mitomycin: A unique case of a patient with an inverted papilloma of the bladder]. 61
33525029 2021
2
Proteomic characterization of arsenic and cadmium exposure in bladder cells. 61
31499585 2020
3
Effects of benzo[a]pyrene, aromatic amines, and a combination of both on CYP1A1 activities in RT-4 human bladder papilloma cells. 61
27924717 2016
4
[Isolated tricuspid valve infective endocarditis in a patient with a urological history]. 61
24868899 2014
5
Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion. 61
24312263 2013
6
Bladder papilloma in a 9-year-old girl: a case report. 61
22555331 2012
7
Toxicology and carcinogenesis studies of pulegone (CAS No. 89-82-7) in F344/N rats and B6C3F1 mice (gavage studies). 61
21921962 2011
8
A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species. 61
20669221 2011
9
Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. 61
18172282 2008
10
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. 61
16777994 2006
11
Elevated prostaglandin E2 level via cPLA2--COX-2--mPGES-1 pathway involved in bladder carcinogenesis induced by terephthalic acid-calculi in Wistar rats. 61
16621493 2006
12
Bladder papilloma in a 12-year-old girl. 61
18947558 2005
13
Glucose transporter-1 expression in urothelial papilloma of the bladder. 61
15812216 2005
14
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. 61
14651997 2003
15
Postoperative course after papilloma resection: effects of written disclosure of the experience in subjects with different alexithymia levels. 61
12764222 2003
16
Surgical management and genotype/phenotype correlations in WT1 gene-related diseases (Drash, Frasier syndromes). 61
12592634 2003
17
Urinary bladder transitional cell papilloma in a shorthorn heifer. 61
11062838 2000
18
[Report of 2 new cases of bladder inverted papilloma, one with them complicated with acute urinary obstruction]. 61
10965580 2000
19
[Study of the synergy of microwave hyperthermia/intravesical chemotherapy in the prevention of recurrences of superficial tumors of the bladder]. 61
10212955 1999
20
Intraductal papillary carcinoma of the parotid gland with low malignancy. 61
10337664 1999
21
Angiogenesis is an early event in the development of chemically induced skin tumors. 61
9886564 1998
22
[A case from practice (359). 1. Gynecomastia 2. Status following right-sided nephrectomy in renal tuberculosis 3. Recurrent microhematuria in bladder papilloma]. 61
8966449 1996
23
NTP Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CAS No. 81-49-2) in F344/N Rats and B6C3F1 Mice (Feed Studies). 61
12692653 1996
24
[Inverted bladder papilloma. Our contribution (7 cases)]. 61
7976716 1994
25
Human müllerian inhibiting substance inhibits tumor growth in vitro and in vivo. 61
2009529 1991
26
[A case of sigmoidovesical and ileovesical fistula with bladder papilloma complicating colonic diverticulitis]. 61
3287852 1988
27
[Follow-up of patients with microhematuria]. 61
3687028 1987
28
The effect of cell extracts of urological tumours on adenovirus mutants. 61
2444045 1987
29
Study of cytotoxicity against adenovirally transformed cells in patients with tumours of the urinary tract. 61
3721766 1986
30
[Papilloma of the bladder in childhood. Description of a case]. 61
3725602 1986
31
Cytology of bladder papilloma. 61
3863430 1985
32
Effect of levamisol on cellular and humoral immune reactivity and on recurrences in patients with bladder papilloma. 61
3835174 1985
33
Cell surface antigens of human bladder cancer defined by mouse monoclonal antibodies. 61
6364135 1984
34
[Papilloma of the gallbladder]. 61
6395977 1983
35
[Bladder papilloma. Treatment with interferon, sodium butyrate and isoprinosine]. 61
6190163 1983
36
[A very unusual tumor: inverted papilloma of the bladder]. 61
6655278 1983
37
Association of depressed mixed lymphocyte reactivity with the development of bladder carcinoma in patients with papillomas. 61
6217888 1983
38
[Clinical significance of inverted bladder papilloma]. 61
7129907 1982
39
Characterization of bladder papilloma by two-parameter DNA-RNA flow cytometry. 61
6174212 1982
40
Systemic IFN-alpha treatment of multiple bladder papilloma grade I or II patients: pilot study. 61
7130757 1982
41
[Thrombopenia caused by heparin. Review of the literature apropos of a personal case]. 61
7142830 1982
42
Bladder papilloma in young patients. 61
7062886 1982
43
Bladder papilloma: therapeutic and cost effect of outpatient department management. 61
6792764 1981
44
Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. 61
7248968 1981
45
[Echotomographic pattern of the gall bladder papilloma (author's transl)]. 61
7268071 1981
46
[Urinary bladder papilloma as a cause of monstrous hydronephrosis]. 61
7282129 1981
47
Urinary proteins as biological markers: bladder cancer diagnosis versus urinary tract infection. 61
6777507 1980
48
Inverted papilloma of the urinary bladder: ultrastructural and immunologic studies. 61
7388768 1980
49
[Adjuvant thio-tepa in the treatment of bladder papilloma. A prospective randomized study]. 61
6773198 1980
50
[Inverted bladder papilloma. Apropos of a case report]. 61
517335 1979

Variations for Bladder Transitional Cell Papilloma

Expression for Bladder Transitional Cell Papilloma

Search GEO for disease gene expression data for Bladder Transitional Cell Papilloma.

Pathways for Bladder Transitional Cell Papilloma

Pathways related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 TP53 PARP1 CYCS CDKN1A CASP2 BIRC5
2
Show member pathways
12.91 TP53 CYCS CDKN1A BIRC5 BID
3
Show member pathways
12.82 TP53 PARP1 CYCS CDKN1A CASP2 BIRC5
4
Show member pathways
12.79 TP53 CYCS CDKN1A CASP2 BIRC5 BID
5
Show member pathways
12.72 TP53 CYCS CDKN1A BIRC5
6
Show member pathways
12.68 TP53 CYCS CDKN1A BID
7
Show member pathways
12.54 PARP1 CYCS CASP2 BID
8 12.42 TP53 TERT FGFR3 CYCS CDKN1A BIRC5
9
Show member pathways
12.41 TP53 PARP1 CYCS CDKN1A CASP2 BID
10
Show member pathways
12.26 TP53 CYCS CDKN1A BID
11
Show member pathways
12.12 TP53 CDKN1A CASP2
12
Show member pathways
12.12 TP53 PARP1 CYCS CDKN1A CASP2 BIRC5
13
Show member pathways
12.07 PARP1 CYCS CASP2 BID
14 12.05 TP53 CDKN1A BIRC5
15 12 TP53 CYCS BID
16 11.95 TP53 TERT CDKN1A
17 11.94 TP53 CDKN1A BID
18
Show member pathways
11.94 TP53 PARP1 CYCS BID
19 11.92 PARP1 CYCS CASP2 BIRC5 BID
20
Show member pathways
11.9 TP53 CYCS BID
21 11.86 TP53 CDKN1A BIRC5
22
Show member pathways
11.78 TP53 CASP2 BIRC5 BID
23 11.75 TP53 CYCS CDKN1A
24 11.69 TP53 TERT BIRC5
25
Show member pathways
11.67 TP53 CDKN1A CASP2 BID
26 11.63 TP53 FGFR3 CDKN1A
27
Show member pathways
11.59 CYCS CASP2 BIRC5 BID
28
Show member pathways
11.48 PARP1 CYCS BID
29 11.45 TP53 CDKN1A BID
30 11.44 TP53 CDKN1A BIRC5
31 11.28 TP53 BIRC5 BID
32 11.17 TP53 BIRC5
33 11.06 TP53 CYCS
34 11.02 PARP1 CYCS
35
Show member pathways
11 TP53 CDKN1A BID
36 10.88 TP53 CYCS CDKN1A BIRC5 BID
37 10.7 TP53 CDKN1A
38
Show member pathways
10.5 TP53 CDKN1A
39 10.15 PARP1 CYCS

GO Terms for Bladder Transitional Cell Papilloma

Cellular components related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.17 TP53 TERT PARP1 CYCS CCN6 CASP2

Biological processes related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.73 TP53 CASP2 BIRC5 BID
2 regulation of cell cycle GO:0051726 9.71 TP53 CDKN1A BIRC5
3 mitochondrion organization GO:0007005 9.63 TERT PARP1 CYCS
4 negative regulation of apoptotic process GO:0043066 9.63 TP53 TERT CDKN1A CASP2 BIRC5 BID
5 positive regulation of reactive oxygen species metabolic process GO:2000379 9.61 TP53 CDKN1A
6 intrinsic apoptotic signaling pathway GO:0097193 9.61 TP53 CDKN1A
7 cellular response to gamma radiation GO:0071480 9.6 TP53 CDKN1A
8 positive regulation of apoptotic signaling pathway GO:2001235 9.59 CASP2 BID
9 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.58 TP53 CDKN1A
10 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.58 TP53 BID
11 response to gamma radiation GO:0010332 9.57 TP53 PARP1
12 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.56 TP53 BID
13 release of cytochrome c from mitochondria GO:0001836 9.55 TP53 BID
14 response to X-ray GO:0010165 9.52 TP53 CDKN1A
15 mitotic cell cycle arrest GO:0071850 9.51 TP53 CDKN1A
16 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.49 TP53 CDKN1A
17 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.48 TP53 TERT
18 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.43 TP53 CDKN1A CASP2
19 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 9.4 TP53 BID
20 mitochondrial DNA repair GO:0043504 9.37 TP53 PARP1
21 signal transduction by p53 class mediator GO:0072331 9.32 TP53 CDKN1A
22 apoptotic process GO:0006915 9.23 TP53 PARP1 KRT20 FGFR3 CYCS CASP2
23 replicative senescence GO:0090399 9.13 TP53 TERT CDKN1A

Molecular functions related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.73 TP53 TERT PARP1 FGFR3 CASP2 BIRC5
2 enzyme binding GO:0019899 9.46 TP53 PARP1 CASP2 BIRC5
3 insulin-like growth factor binding GO:0005520 9.32 CCN6 CCN5
4 protein N-terminus binding GO:0047485 9.13 TP53 TERT PARP1
5 chaperone binding GO:0051087 8.8 TP53 TERT BIRC5

Sources for Bladder Transitional Cell Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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