MCID: BLD049
MIFTS: 37

Bladder Transitional Cell Papilloma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Bladder Transitional Cell Papilloma

MalaCards integrated aliases for Bladder Transitional Cell Papilloma:

Name: Bladder Transitional Cell Papilloma 12 15
Bladder Papilloma 12 74
Transitional Cell Papilloma of Bladder 12
Urinary Bladder Urothelial Papilloma 12
Bladder Urothelial Papilloma 74
Urothelial Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6933
NCIt 51 C3842 C39858
SNOMED-CT 69 45083001

Summaries for Bladder Transitional Cell Papilloma

MalaCards based summary : Bladder Transitional Cell Papilloma, also known as bladder papilloma, is related to ureter urothelial papilloma and urethral urothelial papilloma. An important gene associated with Bladder Transitional Cell Papilloma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Gene Expression and Human cytomegalovirus infection. Affiliated tissues include lung, breast and skin, and related phenotypes are cellular and embryo

Related Diseases for Bladder Transitional Cell Papilloma

Diseases related to Bladder Transitional Cell Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 ureter urothelial papilloma 12.3
2 urethral urothelial papilloma 12.3
3 renal pelvis urothelial papilloma 12.3
4 urinary tract papillary transitional cell benign neoplasm 11.2
5 squamous cell papilloma 10.2
6 papilloma 10.2
7 transitional papilloma 10.2
8 actinic cheilitis 10.1 CDKN1A TP53
9 invasive bladder transitional cell carcinoma 10.1 CDKN1A TP53
10 atypical follicular adenoma 10.1 CDKN1A TP53
11 lip cancer 10.1 CDKN1A TP53
12 suppressor of tumorigenicity 3 10.1 CDKN1A TP53
13 non-invasive bladder papillary urothelial neoplasm 10.1
14 malignant mesenchymoma 10.1 CDKN1A TP53
15 keratoacanthoma 10.1 CDKN1A TP53
16 retinal cancer 10.1 CDKN1A TP53
17 cervical adenocarcinoma 10.1 CDKN1A TP53
18 vulvar intraepithelial neoplasia 10.1 BIRC5 TP53
19 cervical carcinosarcoma 10.1 BIRC5 TP53
20 ocular cancer 10.1 CDKN1A TP53
21 skin melanoma 10.1 CDKN1A TP53
22 keratocystic odontogenic tumor 10.1 BIRC5 TP53
23 tongue cancer 10.0 CDKN1A TP53
24 female reproductive system disease 10.0 PARP1 TP53
25 reproductive system disease 10.0 PARP1 TP53
26 gonadal disease 10.0 PARP1 TP53
27 ovarian serous cystadenocarcinoma 10.0 BIRC5 TP53
28 nervous system cancer 10.0 CDKN1A TP53
29 respiratory system cancer 9.9 PARP1 TP53
30 autonomic nervous system neoplasm 9.9 CYCS TP53
31 hemorrhagic cystitis 9.9 CYCS PARP1
32 amelanotic melanoma 9.9 CYCS PARP1
33 li-fraumeni syndrome 9.9 CDKN1A TP53
34 conn's syndrome 9.8
35 huntington disease 9.7 CASP2 CYCS TP53
36 hepatoblastoma 9.6 BIRC5 CYCS TP53
37 bile duct cancer 9.6 CYCS TP53
38 bladder cancer 9.6 BIRC5 CDKN1A TP53
39 adamantinoma of long bones 9.5 BIRC5 CDKN1A PARP1 TP53
40 ovarian cancer 9.5 BIRC5 CDKN1A PARP1 TP53
41 hepatocellular carcinoma 9.4 BIRC5 CDKN1A PARP1 TP53
42 breast adenocarcinoma 9.4 CDKN1A CYCS PARP1 TP53
43 large intestine cancer 9.4 CDKN1A CYCS PARP1 TP53
44 ewing sarcoma 9.4 CDKN1A CYCS PARP1 TP53
45 lung cancer 9.0 BIRC5 CDKN1A CYCS PARP1 TP53
46 lung cancer susceptibility 3 9.0 BIRC5 CDKN1A CYCS PARP1 TP53
47 cervical cancer 9.0 BIRC5 CDKN1A CYCS PARP1 TP53
48 prostate cancer 9.0 BIRC5 CDKN1A CYCS PARP1 TP53
49 colorectal cancer 9.0 BIRC5 CDKN1A CYCS PARP1 TP53
50 breast cancer 9.0 BIRC5 CDKN1A CYCS PARP1 TP53

Graphical network of the top 20 diseases related to Bladder Transitional Cell Papilloma:



Diseases related to Bladder Transitional Cell Papilloma

Symptoms & Phenotypes for Bladder Transitional Cell Papilloma

MGI Mouse Phenotypes related to Bladder Transitional Cell Papilloma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 BIRC5 CASP2 CDKN1A CYCS PARP1 TP53
2 embryo MP:0005380 9.72 BIRC5 CDKN1A CYCS PARP1 TP53
3 endocrine/exocrine gland MP:0005379 9.65 BIRC5 CASP2 CDKN1A CYCS TP53
4 hematopoietic system MP:0005397 9.63 BIRC5 CASP2 CDKN1A CYCS PARP1 TP53
5 immune system MP:0005387 9.43 BIRC5 CASP2 CDKN1A CYCS PARP1 TP53
6 mortality/aging MP:0010768 9.1 BIRC5 CASP2 CDKN1A CYCS PARP1 TP53

Drugs & Therapeutics for Bladder Transitional Cell Papilloma

Search Clinical Trials , NIH Clinical Center for Bladder Transitional Cell Papilloma

Genetic Tests for Bladder Transitional Cell Papilloma

Anatomical Context for Bladder Transitional Cell Papilloma

MalaCards organs/tissues related to Bladder Transitional Cell Papilloma:

42
Lung, Breast, Skin, Bone, Tongue, Prostate

Publications for Bladder Transitional Cell Papilloma

Articles related to Bladder Transitional Cell Papilloma:

(show all 20)
# Title Authors Year
1
Effects of benzo[a]pyrene, aromatic amines, and a combination of both on CYP1A1 activities in RT-4 human bladder papilloma cells. ( 27924717 )
2016
2
Bladder papilloma in a 9-year-old girl: a case report. ( 22555331 )
2012
3
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. ( 16777994 )
2006
4
Bladder papilloma in a 12-year-old girl. ( 18947558 )
2005
5
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. ( 14651997 )
2003
6
Urinary bladder transitional cell papilloma in a shorthorn heifer. ( 11062838 )
2000
7
Effect of levamisol on cellular and humoral immune reactivity and on recurrences in patients with bladder papilloma. ( 3835174 )
1985
8
Cytology of bladder papilloma. ( 3863430 )
1985
9
Characterization of bladder papilloma by two-parameter DNA-RNA flow cytometry. ( 6174212 )
1982
10
Bladder papilloma in young patients. ( 7062886 )
1982
11
Systemic IFN-alpha treatment of multiple bladder papilloma grade I or II patients: pilot study. ( 7130757 )
1982
12
Bladder papilloma: therapeutic and cost effect of outpatient department management. ( 6792764 )
1981
13
Recurrent bladder papilloma in a child with Cushing's syndrome. Case report. ( 482873 )
1979
14
Bladder papilloma in a child. Case report. ( 1209187 )
1975
15
Bladder papilloma in a child. ( 5156624 )
1971
16
The association of benign bladder papilloma with cancers of sites other than the bladder and ureter. ( 5459976 )
1970
17
Bladder papilloma in a child: case report. ( 5761764 )
1969
18
Bladder papilloma. An analysis of 75 cases. ( 13838095 )
1960
19
Results of treatment of bladder papilloma by diathermy, from the Western Infirmary, Glasgow. ( 14791987 )
1950
20
THE TREATMENT OF BLADDER PAPILLOMA BY HIGH FREQUENCY DESTRUCTION. ( 17863234 )
1914

Variations for Bladder Transitional Cell Papilloma

Expression for Bladder Transitional Cell Papilloma

Search GEO for disease gene expression data for Bladder Transitional Cell Papilloma.

Pathways for Bladder Transitional Cell Papilloma

Pathways related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.43 BIRC5 CASP2 CDKN1A CYCS PARP1 TP53
2
Show member pathways
12.72 BIRC5 CDKN1A CYCS TP53
3
Show member pathways
12.62 BIRC5 CDKN1A CYCS TP53
4 12.59 BIRC5 CDKN1A CYCS TP53
5
Show member pathways
12.58 CASP2 CDKN1A CYCS PARP1 TP53
6
Show member pathways
12.54 BIRC5 CASP2 CDKN1A CYCS TP53
7
Show member pathways
12.38 BIRC5 CDKN1A TP53
8
Show member pathways
12.38 BIRC5 PARP1 TP53
9
Show member pathways
12.29 CASP2 CYCS PARP1
10
Show member pathways
12.2 BIRC5 CDKN1A TP53
11
Show member pathways
12.18 CDKN1A CYCS TP53
12
Show member pathways
12.16 CASP2 CDKN1A CYCS PARP1 TP53
13
Show member pathways
12.07 CASP2 CYCS PARP1
14
Show member pathways
12.06 CASP2 CDKN1A TP53
15 11.99 BIRC5 CDKN1A TP53
16
Show member pathways
11.94 CASP2 CDKN1A CYCS
17
Show member pathways
11.86 CYCS PARP1 TP53
18 11.82 BIRC5 CASP2 CYCS PARP1
19
Show member pathways
11.8 BIRC5 CASP2 CDKN1A CYCS PARP1 TP53
20 11.79 BIRC5 CDKN1A TP53
21
Show member pathways
11.74 BIRC5 CASP2 TP53
22 11.65 CDKN1A TP53
23 11.65 CDKN1A CYCS TP53
24 11.63 CYCS TP53
25 11.62 CASP2 CYCS
26 11.61 CDKN1A TP53
27 11.6 BIRC5 TP53
28
Show member pathways
11.59 CASP2 CDKN1A TP53
29 11.56 CDKN1A TP53
30
Show member pathways
11.56 BIRC5 CASP2 CYCS
31
Show member pathways
11.51 CYCS TP53
33 11.39 CDKN1A TP53
34 11.38 CDKN1A TP53
35
Show member pathways
11.37 CYCS PARP1
36 11.34 CDKN1A TP53
37 11.31 CDKN1A TP53
38 11.25 CDKN1A TP53
39 11.25 BIRC5 CDKN1A TP53
40 11.23 BIRC5 TP53
41 11.16 CDKN1A TP53
42 11.14 BIRC5 TP53
43 11.12 BIRC5 CDKN1A CYCS TP53
44 11.09 CYCS PARP1 TP53
45 10.99 CYCS PARP1
46
Show member pathways
10.96 CDKN1A TP53
47 10.66 CDKN1A TP53
48
Show member pathways
10.45 CDKN1A TP53
49 10.03 CYCS PARP1

GO Terms for Bladder Transitional Cell Papilloma

Cellular components related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 8.92 CASP2 CYCS PARP1 TP53

Biological processes related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.72 CDKN1A PARP1 TP53
2 cytokine-mediated signaling pathway GO:0019221 9.67 BIRC5 CDKN1A TP53
3 regulation of apoptotic process GO:0042981 9.63 BIRC5 CASP2 TP53
4 negative regulation of apoptotic process GO:0043066 9.62 BIRC5 CASP2 CDKN1A TP53
5 cellular response to oxidative stress GO:0034599 9.56 CYCS PARP1
6 Ras protein signal transduction GO:0007265 9.54 CDKN1A TP53
7 cellular response to UV GO:0034644 9.52 PARP1 TP53
8 regulation of mitotic cell cycle GO:0007346 9.51 BIRC5 CDKN1A
9 cellular response to ionizing radiation GO:0071479 9.48 CDKN1A TP53
10 positive regulation of reactive oxygen species metabolic process GO:2000379 9.43 CDKN1A TP53
11 response to gamma radiation GO:0010332 9.4 PARP1 TP53
12 replicative senescence GO:0090399 9.37 CDKN1A TP53
13 apoptotic process GO:0006915 9.35 BIRC5 CASP2 CYCS PARP1 TP53
14 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.33 CASP2 CDKN1A TP53
15 signal transduction by p53 class mediator GO:0072331 9.26 CDKN1A TP53
16 intrinsic apoptotic signaling pathway GO:0097193 8.62 CDKN1A TP53

Molecular functions related to Bladder Transitional Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.33 CDKN1A PARP1 TP53
2 identical protein binding GO:0042802 9.26 BIRC5 CASP2 PARP1 TP53
3 enzyme binding GO:0019899 8.92 BIRC5 CASP2 PARP1 TP53

Sources for Bladder Transitional Cell Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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