MCID: BLD050
MIFTS: 24

Bladder Urachal Carcinoma

Categories: Cancer diseases, Endocrine diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Bladder Urachal Carcinoma

MalaCards integrated aliases for Bladder Urachal Carcinoma:

Name: Bladder Urachal Carcinoma 12 70
Urachal Cancer 12 73 20 44 70
Urachal Carcinoma 20

Classifications:



External Ids:

Disease Ontology 12 DOID:5958
MeSH 44 C536475
NCIt 50 C39842
UMLS 70 C1511205 C2931202

Summaries for Bladder Urachal Carcinoma

GARD : 20 Urachal cancer is a type of bladder cancer, making up less than 1% of all bladder cancers. The urachus is a structure normally only present during development in the womb that connects the bellybutton and the bladder. This connection normally disappears before birth, but in some people remains. Urachal cancers are usually diagnosed in adults in their 50's and 60's and may develop at the dome or anterior wall of the bladder, along the midline of the body (including the belly button), and between the pubis symphasis and the bladder. Most urachal cancers are adenocarcinomas (cancers that develop from gland cells ). Others may be sarcomas (which develop from connective tissue - such as leiomyosarcoma, rhabdomyosarcoma, and malignant fibrous histiocytoma ), small cell carcinomas, transitional cell cancer, and mixed neoplasias. Most individuals with urachal cancer have symptoms of with hematuria (blood in urine). Other symptoms may include abdominal pain, a palpable abdominal mass, mucinuria, and bacteriuria. Treatment usually involved surgery to remove the cancer.

MalaCards based summary : Bladder Urachal Carcinoma, also known as urachal cancer, is related to urachal adenocarcinoma and papillary adenocarcinoma, and has symptoms including pain The drugs Fluorouracil and Oxaliplatin have been mentioned in the context of this disorder. Affiliated tissues include colon, eye and lymph node.

Wikipedia : 73 Urachal cancer is a very rare type of cancer arising from the urachus or its remnants. The disease might... more...

Related Diseases for Bladder Urachal Carcinoma

Diseases related to Bladder Urachal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 urachal adenocarcinoma 10.2
2 papillary adenocarcinoma 10.1
3 rare tumor 10.1
4 acute cystitis 10.0
5 transitional cell carcinoma 10.0
6 bladder urothelial carcinoma 10.0
7 peritonitis 10.0
8 urachal diverticulum 10.0
9 adenocarcinoma 10.0
10 ataxia and polyneuropathy, adult-onset 9.9
11 lung cancer susceptibility 3 9.9
12 small cell carcinoma 9.9
13 colorectal adenocarcinoma 9.9
14 villous adenoma 9.9
15 inflammatory myofibroblastic tumor 9.9
16 gallbladder disease 9.9
17 bone disease 9.9
18 b-lymphoblastic leukemia/lymphoma 9.9
19 urinary tract infection 9.9
20 prostatitis 9.9
21 leiomyosarcoma 9.9
22 glandular cystitis 9.9
23 cystadenoma 9.9
24 endometriosis 9.9
25 cystadenocarcinoma 9.9
26 signet ring cell adenocarcinoma 9.9
27 pseudomyxoma peritonei 9.9
28 lymphoepithelioma-like carcinoma 9.9
29 cystitis cystica 9.9
30 diverticulitis 9.9
31 end stage renal disease 9.9
32 ileus 9.9
33 paralytic ileus 9.9
34 actinomycosis 9.9
35 in situ carcinoma 9.9
36 meningitis 9.9
37 bladder cancer 9.9
38 suppression of tumorigenicity 12 9.9
39 familial adenomatous polyposis 9.9
40 neutropenia 9.9
41 cystitis 9.9
42 sensory peripheral neuropathy 9.9
43 hemangioma 9.9
44 transverse colon cancer 9.9
45 mucinous adenocarcinoma 9.9
46 appendix adenocarcinoma 9.9
47 thrombophlebitis 9.9
48 cavernous hemangioma 9.9
49 fasciitis 9.9
50 malakoplakia 9.9

Graphical network of the top 20 diseases related to Bladder Urachal Carcinoma:



Diseases related to Bladder Urachal Carcinoma

Symptoms & Phenotypes for Bladder Urachal Carcinoma

UMLS symptoms related to Bladder Urachal Carcinoma:


pain

Drugs & Therapeutics for Bladder Urachal Carcinoma

Drugs for Bladder Urachal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 2 51-21-8 3385
2
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
3
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
4
leucovorin Approved Phase 2 58-05-9 6006
5 Folfirinox Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter Prospective Phase II Study of Modified FOLFIRINOX for 1st Line Treatment for Advanced Urachus Cancer Recruiting NCT04611724 Phase 2 FOLFIRINOX

Search NIH Clinical Center for Bladder Urachal Carcinoma

Cochrane evidence based reviews: urachal cancer

Genetic Tests for Bladder Urachal Carcinoma

Anatomical Context for Bladder Urachal Carcinoma

MalaCards organs/tissues related to Bladder Urachal Carcinoma:

40
Colon, Eye, Lymph Node

Publications for Bladder Urachal Carcinoma

Articles related to Bladder Urachal Carcinoma:

(show top 50) (show all 83)
# Title Authors PMID Year
1
Predictors of survival from urachal cancer: a Mayo Clinic study of 49 cases. 61 20
17932892 2007
2
Radionuclide-guided sentinel lymph node mapping in urachal cancer. 61
33650332 2021
3
Cyclops' eye-like large ulcerated umbilical mass: a rare presentation of urachal cancer. 61
32678469 2021
4
Urachal adenocarcinoma. Analysis of 8 years in a third level medical facility. 61
33498072 2021
5
Prevalence of APC and PTEN Alterations in Urachal Cancer. 61
32754865 2020
6
Phase I trial of the MET inhibitor tepotinib in Japanese patients with solid tumors. 61
32328660 2020
7
[Rare Cancers in the Genitourinary Tract]. 61
32668844 2020
8
Ex vivo modelling of drug efficacy in a rare metastatic urachal carcinoma. 61
32576176 2020
9
Urachal carcinoma: Impact of recurrence pattern and lymphadenectomy on long-term outcomes. 61
32329250 2020
10
Management of urachal cancer: A consensus statement by the Canadian Urological Association and Genitourinary Medical Oncologists of Canada. 61
31348743 2020
11
Urachal Cancer in Germany and the USA: An RKI/SEER Population-Based Comparison Study. 61
32784300 2020
12
[Metastatic Brain Tumor from Urachal Cancer:A Case Report]. 61
31874948 2019
13
[Urachal Cancer: an update of current molecular findings]. 61
31705235 2019
14
Radical cystoprostatectomy to treat urachal carcinoma. 61
31656427 2019
15
[A Case of Urachal Cancer at the Inserted Site of Cystostomy after 23 Years]. 61
31631166 2019
16
Long-term survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with peritoneal metastases of urachal cancer. 61
31003721 2019
17
Metastatic urachal cancer treated effectively with gemcitabine/cisplatin combination chemotherapy and radiotherapy: A case report. 61
31281647 2019
18
Mystery of neck lump: an uncommon presentation of urachal cancer. 61
31451464 2019
19
Urachal cancer-current concepts of a rare cancer. 61
30895340 2019
20
A Large Urinary Bladder Hemangioma Mimicking Urachal Cancer: A Case Report and Literature Review. 61
30308263 2019
21
Imaging Features of Urachal Cancer: A Case Report. 61
31850195 2019
22
[Urachal cancer - current concepts of a rare cancer (German version)]. 61
30470871 2018
23
Pathogenic and targetable genetic alterations in 70 urachal adenocarcinomas. 61
29672836 2018
24
A rare inflammatory myofibroblastic bladder tumor masquerading urachal carcinoma. 61
30089997 2018
25
[Unexpected differential diagnosis of urachal cancer]. 61
29796699 2018
26
Malignant transformation of a urachal cyst-a case report and literature review. 61
30271532 2018
27
Biomarkers in Urachal Cancer and Adenocarcinomas in the Bladder: A Comprehensive Review Supplemented by Own Data. 61
29721106 2018
28
Telomerase reverse transcriptase (TERT) promoter mutations are rare in urachal cancer. 61
29047227 2017
29
Comprehensive somatic genome alterations of urachal carcinoma. 61
28348108 2017
30
Urachal Carcinoma Shares Genomic Alterations with Colorectal Carcinoma and May Respond to Epidermal Growth Factor Inhibition. 61
27178450 2016
31
Genetics and biological markers in urachal cancer. 61
27785422 2016
32
Clinical, prognostic, and therapeutic aspects of urachal carcinoma-A comprehensive review with meta-analysis of 1,010 cases. 61
27267737 2016
33
A Case of Metastatic Urachal Cancer Including a Neuroendocrine Component Treated with Gemcitabine, Cisplatin and Paclitaxel Combination Chemotherapy. 61
27339213 2016
34
Incidentally discovered urachal cancer in a patient with necrotising fasciitis of the abdominal wall. 61
27118740 2016
35
Urachal cancer: contemporary review of the pathological, surgical, and prognostic aspects of this rare disease. 61
26583595 2016
36
Updates in the Pathologic Diagnosis and Classification of Epithelial Neoplasms of Urachal Origin. 61
26849813 2016
37
[Surgical Treatment for Refractory Metastatic Lung Tumors from Urachal Carcinoma after Chemotherapy]. 61
27075288 2016
38
Clinical outcome of urachal cancer in Japanese patients. 61
26138265 2016
39
Primary Umbilical Endometriosis: Unusual and Rare Clinical Presentation. 61
27242939 2016
40
[Carcinoma of Unknown Primary Associated with a Sister Mary Joseph's Nodule--A Case Report]. 61
26805190 2015
41
Urachal rhabdomyosarcoma in childhood: a rare entity with a poor outcome. 61
25913896 2015
42
Cystoscopic findings: a video tutorial. 61
25619539 2015
43
A Case of Urachal Malacoplakia that Seems Like Urachal Cancer. 61
25759783 2015
44
Neoadjuvant chemotherapy for primary adenocarcinomas of the urinary bladder: a single-site experience. 61
25631709 2015
45
The Youngest Korean Case of Urachal Carcinoma. 61
26146584 2015
46
Investigating urachal carcinoma for more than 15 years. 61
25295114 2014
47
Prognostic factors for urachal cancer: a bayesian model-averaging approach. 61
25237458 2014
48
Urachal cancer with direct caecal invasion: differential diagnosis from primary colon cancer. 61
24903722 2014
49
[Two cases of lower abdominal tumors difficult to differentiate from urachal tumors]. 61
24605582 2014
50
Treatment Outcome and Relevance of Palliative Chemotherapy in Urachal Cancer. 61
25471123 2014

Variations for Bladder Urachal Carcinoma

Expression for Bladder Urachal Carcinoma

Search GEO for disease gene expression data for Bladder Urachal Carcinoma.

Pathways for Bladder Urachal Carcinoma

GO Terms for Bladder Urachal Carcinoma

Sources for Bladder Urachal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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