MCID: BLS002
MIFTS: 42

Blastomycosis

Categories: Infectious diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Blastomycosis

MalaCards integrated aliases for Blastomycosis:

Name: Blastomycosis 12 77 54 45 15 17 74 3
North American Blastomycosis 12 54
Gilchrist's Disease 12 54
Infection by Blastomyces Dermatitidis 12
Blastomyces Dermatitidis Infection 12
Blastomycotic Infection 12
Gilchrist Disease 74
Chicago Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12663
ICD9CM 36 116 116.0
MeSH 45 D001759
NCIt 51 C34428
SNOMED-CT 69 10673008 69996000
ICD10 34 B40 B40.9

Summaries for Blastomycosis

CDC : 3 Blastomycosis is an infection caused by a fungus called Blastomyces. The fungus lives in the environment, particularly in moist soil and in decomposing matter such as wood and leaves. Blastomyces mainly lives in areas of the United States and Canada surrounding the Ohio and Mississippi River valleys and the Great Lakes. People can get blastomycosis after breathing in the microscopic fungal spores from the air. Although most people who breathe in the spores don’t get sick, some of those who do may have flu-like symptoms, and the infection can sometimes become serious if it is not treated.

MalaCards based summary : Blastomycosis, also known as north american blastomycosis, is related to lobomycosis and paracoccidioidomycosis, and has symptoms including skin lesions, lung lesions and pleural thickening. An important gene associated with Blastomycosis is GC (GC Vitamin D Binding Protein). The drugs Miconazole and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and bone.

Disease Ontology : 12 A primary systemic mycosis that results in a systemic fungal infection, has material basis in Blastomyces dermatitidis, transmitted by airborne spores and has symptom skin lesions, has symptom lung lesions and has symptom pleural thickening.

NIH Rare Diseases : 54 Blastomycosis is a rare infection that may develop when people inhale a fungus called Blastomyces dermatitidis, a fungus that is found in moist soil, particularly where there is rotting vegetation. The fungus enters the body through the lungs, infecting them. The fungus then spreads to other areas of the body. The infection may affect the skin, bones and joints, and other areas. The disease usually affects people with weakened immune systems, such as those with HIV or who have had an organ transplant.

Wikipedia : 77 Blastomycosis (also known as "North American blastomycosis", "blastomycetic dermatitis", and... more...

Related Diseases for Blastomycosis

Graphical network of the top 20 diseases related to Blastomycosis:



Diseases related to Blastomycosis

Symptoms & Phenotypes for Blastomycosis

Symptoms:

12
  • skin lesions
  • lung lesions
  • pleural thickening

Drugs & Therapeutics for Blastomycosis

Drugs for Blastomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
2
Amphotericin B Approved, Investigational Phase 4,Phase 3 1397-89-3 14956 5280965
3
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
4
deoxycholic acid Approved Phase 4 83-44-3 222528
5 Anti-Bacterial Agents Phase 4,Phase 3
6 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
8 Antiprotozoal Agents Phase 4,Phase 3
9 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
12 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
13 Antiparasitic Agents Phase 4,Phase 3
14 Liposomal amphotericin B Phase 4,Phase 3
15 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
16 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Amphotericin B, deoxycholate drug combination Phase 4
18
Itraconazole Approved, Investigational Phase 3,Phase 1,Phase 2,Early Phase 1 84625-61-6 55283
19 Antibiotics, Antitubercular Phase 3
20
Hydroxyitraconazole Phase 3,Phase 1,Phase 2,Early Phase 1
21 Pharmaceutical Solutions Phase 3,Early Phase 1
22
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
23 Cytochrome P-450 CYP2C19 Inhibitors Phase 2
24 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
25
Petrolatum Approved, Investigational Early Phase 1 8009-03-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Amphotericin-B and Voriconazole for Pulmonary Blastomycosis Suspended NCT02283905 Phase 4 amphotericin-B;voriconazole
2 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3 Itraconazole;Amphotericin B
3 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
4 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
5 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
6 Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Blastomycosis Dermatitidis Infection in Patients Not Infected With HIV and Complications Associated With Blastomycosis Dermatitidis Infection Completed NCT00001702
7 Topical Itraconazole in the Treatment of Basal Cell Carcinoma Completed NCT02120677 Early Phase 1 Itraconazole

Search NIH Clinical Center for Blastomycosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: blastomycosis

Genetic Tests for Blastomycosis

Anatomical Context for Blastomycosis

MalaCards organs/tissues related to Blastomycosis:

42
Lung, Skin, Bone, Testes, Prostate, Thyroid, Eye

Publications for Blastomycosis

Articles related to Blastomycosis:

(show top 50) (show all 1292)
# Title Authors Year
1
Disseminated Blastomycosis in a Teenager Presenting with Pleural Effusion and Splenomegaly. ( 30691698 )
2019
2
Successful Treatment of Cutaneous Blastomycosis in a Renal Transplant Patient With BK Virus Infection: A Case Report. ( 30879591 )
2019
3
Blastomycosis in Southern Saskatchewan 2000-2015: Unique presentations and disease characteristics. ( 29924358 )
2018
4
Primary Cutaneous Blastomycosis After Inoculation From A Woodworking Blade. ( 29169917 )
2018
5
Urinary tract blastomycosis diagnosed by urine cytology. ( 29573229 )
2018
6
Chronic Pulmonary Blastomycosis Mimicking Pulmonary Tuberculosis. ( 29547956 )
2018
7
Disseminated blastomycosis in a transplant patient. ( 29512289 )
2018
8
Blastomycosis-like Pyoderma Arising in Lichen Planus. ( 29462233 )
2018
9
Pyoderma Gangranosum-Like Blastomycosis. ( 29486592 )
2018
10
Central nervous system blastomycosis diagnosed using the MVistaAr Blastomyces quantitative antigen enzyme immunoassay test on cerebrospinal fluid: A case report and review of the literature. ( 29195765 )
2018
11
Erratum: Blastomycosis-like pyoderma: Novel use of potassium iodide. ( 29923506 )
2018
12
Cutaneous, Intranasal Blastomycosis Infection in Two Patients from Southern West Virginia: Diagnostic Dilemma. ( 29568716 )
2018
13
Disseminated Cutaneous Blastomycosis. ( 29972741 )
2018
14
Epidemiology and Geographic Distribution of Blastomycosis, Histoplasmosis, and Coccidioidomycosis, Ontario, Canada, 1990-2015. ( 29912691 )
2018
15
Pulmonary blastomycosis presenting as primary lung cancer. ( 30021526 )
2018
16
Blastomycosis in a renal transplant recipient: Case of immune reconstitution inflammatory syndrome. ( 30023163 )
2018
17
25-Hydroxyvitamin D concentrations in dogs with naturally acquired blastomycosis. ( 30079575 )
2018
18
Incidental findings of blastomycosis lung nodules in five asymptomatic patients. ( 30094129 )
2018
19
Notes from the Field: Blastomycosis Cases Occurring Outside of Regions with Known Endemicity - New York, 2007-2017. ( 30260940 )
2018
20
Disseminated blastomycosis in a 36-year-old immunocompetent male from Chicago, IL. ( 30263127 )
2018
21
Blastomycosis-like pyoderma: a diagnostic as well as therapeutic challenge. ( 30428650 )
2018
22
Fatal blastomycosis after exogenous immunosuppression in a healthy gardener. ( 30450406 )
2018
23
Disseminated blastomycosis with cutaneous lesions mimicking tuberculosis. ( 30507461 )
2018
24
Potential clinical utility of ERC-2 yeast phase lysate antigen for antibody detection in dogs with blastomycosis. ( 30544205 )
2018
25
Pediatric primary cutaneous blastomycosis clinically responsive to itraconazole. ( 30566541 )
2018
26
Imaging Patterns of Pediatric Pulmonary Blastomycosis. ( 30589384 )
2018
27
Mandibular blastomycosis: A case report and review of the literature. ( 30775340 )
2018
28
Blastomycosis ( 28723016 )
2017
29
Blastomycosis during pregnancy: a case report and review of the literature. ( 28291633 )
2017
30
A retrospective study of anti-inflammatory use in dogs with pulmonary blastomycosis: 139 cases (2002-2012). ( 28561957 )
2017
31
Fine needle aspiration cytology of acute blastomycosis thyroiditis. ( 28792123 )
2017
32
Successful treatment of blastomycosis in a 7-year-old, female golden retriever dog on Manitoulin Island, Ontario. ( 28588338 )
2017
33
Cutaneous blastomycosis and dermatophytic pseudomycetoma in a Persian cat from Bangkok, Thailand. ( 28116230 )
2017
34
Blastomycosis hospitalizations in northwestern Ontario: 2006-2015. ( 29770046 )
2017
35
Blastomycosis-like pyoderma: Novel use of potassium iodide. ( 28980537 )
2017
36
Clinical Manifestations and Treatment of Blastomycosis. ( 28797487 )
2017
37
Disseminated blastomycosis in a 57-year-old man working in construction. ( 29229716 )
2017
38
An Atypical Case of Mucocutaneous Blastomycosis in the Greater Toronto Area. ( 28300442 )
2017
39
Invasive Trichophyton rubrum mimicking blastomycosis in a patient with solid organ transplant. ( 28627008 )
2017
40
Disseminated Blastomycosis Mimicking Malignancy. ( 28813733 )
2017
41
Disseminated Blastomycosis. ( 28177861 )
2017
42
Not just another Wisconsin case of blastomycosis. ( 29293961 )
2017
43
Blastomycosis-Like Pyoderma- A Rare Case Report. ( 27891438 )
2016
44
Diagnostic Delay and Antibiotic Overuse in Acute Pulmonary Blastomycosis. ( 27419155 )
2016
45
Central Nervous System Blastomycosis in Children - A Case Report and Review of the Literature. ( 28033237 )
2016
46
Multimodality imaging in cranial blastomycosis, a great mimicker: Case-based illustration with review of clinical and imaging findings. ( 27081235 )
2016
47
Blastomycosis. ( 26739607 )
2016
48
Blastomycosis of the nose: A case report. ( 27551850 )
2016
49
Reversal of Fortune: Central Nervous System Blastomycosis. ( 26477951 )
2016
50
SYSTEMIC BLASTOMYCOSIS IN A CAPTIVE RED RUFFED LEMUR (VARECIA RUBRA). ( 27691971 )
2016

Variations for Blastomycosis

Expression for Blastomycosis

Search GEO for disease gene expression data for Blastomycosis.

Pathways for Blastomycosis

GO Terms for Blastomycosis

Sources for Blastomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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