MCID: BLS002
MIFTS: 41

Blastomycosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Blastomycosis

MalaCards integrated aliases for Blastomycosis:

Name: Blastomycosis 12 77 54 3 45 15 17 74
North American Blastomycosis 12 54
Gilchrist's Disease 12 54
Infection by Blastomyces Dermatitidis 12
Blastomyces Dermatitidis Infection 12
Blastomycotic Infection 12
Gilchrist Disease 74
Chicago Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12663
ICD9CM 36 116 116.0
MeSH 45 D001759
NCIt 51 C34428
SNOMED-CT 69 10673008 69996000
ICD10 34 B40 B40.9

Summaries for Blastomycosis

CDC : 3 Blastomycosis is an infection caused by a fungus called Blastomyces. The fungus lives in the environment, particularly in moist soil and in decomposing matter such as wood and leaves. Blastomyces mainly lives in areas of the United States and Canada surrounding the Ohio and Mississippi River valleys and the Great Lakes. People can get blastomycosis after breathing in the microscopic fungal spores from the air. Although most people who breathe in the spores don’t get sick, some of those who do may have flu-like symptoms, and the infection can sometimes become serious if it is not treated.

MalaCards based summary : Blastomycosis, also known as north american blastomycosis, is related to lobomycosis and paracoccidioidomycosis, and has symptoms including skin lesions, lung lesions and pleural thickening. An important gene associated with Blastomycosis is GC (GC Vitamin D Binding Protein). The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and bone.

Disease Ontology : 12 A primary systemic mycosis that results in a systemic fungal infection, has material basis in Blastomyces dermatitidis, transmitted by airborne spores and has symptom skin lesions, has symptom lung lesions and has symptom pleural thickening.

NIH Rare Diseases : 54 Blastomycosis is a rare infection that may develop when people inhale a fungus called Blastomyces dermatitidis, a fungus that is found in moist soil, particularly where there is rotting vegetation. The fungus enters the body through the lungs, infecting them. The fungus then spreads to other areas of the body. The infection may affect the skin, bones and joints, and other areas. The disease usually affects people with weakened immune systems, such as those with HIV or who have had an organ transplant.

Wikipedia : 77 Blastomycosis, also known as North American blastomycosis, is a fungal infection caused by inhaling... more...

Related Diseases for Blastomycosis

Graphical network of the top 20 diseases related to Blastomycosis:



Diseases related to Blastomycosis

Symptoms & Phenotypes for Blastomycosis

Symptoms:

12
  • skin lesions
  • lung lesions
  • pleural thickening

Drugs & Therapeutics for Blastomycosis

Drugs for Blastomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 4,Phase 3 1397-89-3 5280965 14956
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
3
deoxycholic acid Approved Phase 4 83-44-3 222528
4
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
5 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
6 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7 Anti-Bacterial Agents Phase 4,Phase 3
8 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
9 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
11 Antiparasitic Agents Phase 4,Phase 3
12 Liposomal amphotericin B Phase 4,Phase 3
13 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
14 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
15 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
16 Antiprotozoal Agents Phase 4,Phase 3
17 Amphotericin B, deoxycholate drug combination Phase 4
18
Itraconazole Approved, Investigational Phase 3,Phase 1,Phase 2,Early Phase 1 84625-61-6 55283
19 Antibiotics, Antitubercular Phase 3
20
Hydroxyitraconazole Phase 3,Phase 1,Phase 2,Early Phase 1
21 Pharmaceutical Solutions Phase 3,Early Phase 1
22
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
23 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
24 Cytochrome P-450 CYP2C19 Inhibitors Phase 2
25
Petrolatum Approved, Investigational Early Phase 1 8009-03-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Amphotericin-B and Voriconazole for Pulmonary Blastomycosis Suspended NCT02283905 Phase 4 amphotericin-B;voriconazole
2 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3 Itraconazole;Amphotericin B
3 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
4 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
5 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
6 Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Blastomycosis Dermatitidis Infection in Patients Not Infected With HIV and Complications Associated With Blastomycosis Dermatitidis Infection Completed NCT00001702
7 Topical Itraconazole in the Treatment of Basal Cell Carcinoma Completed NCT02120677 Early Phase 1 Itraconazole

Search NIH Clinical Center for Blastomycosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: blastomycosis

Genetic Tests for Blastomycosis

Anatomical Context for Blastomycosis

MalaCards organs/tissues related to Blastomycosis:

42
Lung, Skin, Bone, Testes, Thyroid, Prostate, Eye

Publications for Blastomycosis

Articles related to Blastomycosis:

(show top 50) (show all 1296)
# Title Authors Year
1
Blastomycosis-like Pyoderma. ( 31037854 )
2019
2
Atypical blastomycosis in a pregnant woman. ( 30997389 )
2019
3
Apparent interference with extracorporeal membrane oxygenation by liposomal amphotericin B in a patient with disseminated blastomycosis receiving continuous renal replacement therapy. ( 30994894 )
2019
4
The Blastomycosis Bluff by Purpureocillium lilacinum. ( 30947843 )
2019
5
Successful Treatment of Cutaneous Blastomycosis in a Renal Transplant Patient With BK Virus Infection: A Case Report. ( 30879591 )
2019
6
Disseminated Blastomycosis in a Teenager Presenting with Pleural Effusion and Splenomegaly. ( 30691698 )
2019
7
Veno-venous extracorporeal life support for blastomycosis-associated acute respiratory distress syndrome. ( 31027465 )
2019
8
Mandibular blastomycosis: A case report and review of the literature. ( 30775340 )
2018
9
Imaging Patterns of Pediatric Pulmonary Blastomycosis. ( 30589384 )
2018
10
Pediatric primary cutaneous blastomycosis clinically responsive to itraconazole. ( 30566541 )
2018
11
Potential clinical utility of ERC-2 yeast phase lysate antigen for antibody detection in dogs with blastomycosis. ( 30544205 )
2018
12
Disseminated blastomycosis with cutaneous lesions mimicking tuberculosis. ( 30507461 )
2018
13
Fatal blastomycosis after exogenous immunosuppression in a healthy gardener. ( 30450406 )
2018
14
Blastomycosis-like pyoderma: a diagnostic as well as therapeutic challenge. ( 30428650 )
2018
15
Disseminated blastomycosis in a 36-year-old immunocompetent male from Chicago, IL. ( 30263127 )
2018
16
Notes from the Field: Blastomycosis Cases Occurring Outside of Regions with Known Endemicity - New York, 2007-2017. ( 30260940 )
2018
17
Incidental findings of blastomycosis lung nodules in five asymptomatic patients. ( 30094129 )
2018
18
25-Hydroxyvitamin D concentrations in dogs with naturally acquired blastomycosis. ( 30079575 )
2018
19
Blastomycosis in a renal transplant recipient: Case of immune reconstitution inflammatory syndrome. ( 30023163 )
2018
20
Pulmonary blastomycosis presenting as primary lung cancer. ( 30021526 )
2018
21
Disseminated Cutaneous Blastomycosis. ( 29972741 )
2018
22
Blastomycosis in Southern Saskatchewan 2000-2015: Unique presentations and disease characteristics. ( 29924358 )
2018
23
Erratum: Blastomycosis-like pyoderma: Novel use of potassium iodide. ( 29923506 )
2018
24
Epidemiology and Geographic Distribution of Blastomycosis, Histoplasmosis, and Coccidioidomycosis, Ontario, Canada, 1990-2015. ( 29912691 )
2018
25
Urinary tract blastomycosis diagnosed by urine cytology. ( 29573229 )
2018
26
Cutaneous, Intranasal Blastomycosis Infection in Two Patients from Southern West Virginia: Diagnostic Dilemma. ( 29568716 )
2018
27
Chronic Pulmonary Blastomycosis Mimicking Pulmonary Tuberculosis. ( 29547956 )
2018
28
Disseminated blastomycosis in a transplant patient. ( 29512289 )
2018
29
Pyoderma Gangranosum-Like Blastomycosis. ( 29486592 )
2018
30
Blastomycosis-like Pyoderma Arising in Lichen Planus. ( 29462233 )
2018
31
Not just another Wisconsin case of blastomycosis. ( 29293961 )
2018
32
Central nervous system blastomycosis diagnosed using the MVista® Blastomyces quantitative antigen enzyme immunoassay test on cerebrospinal fluid: A case report and review of the literature. ( 29195765 )
2018
33
Primary Cutaneous Blastomycosis After Inoculation From A Woodworking Blade. ( 29169917 )
2018
34
Blastomycosis hospitalizations in northwestern Ontario: 2006-2015. ( 29770046 )
2017
35
Disseminated blastomycosis in a 57-year-old man working in construction. ( 29229716 )
2017
36
Blastomycosis-like pyoderma: Novel use of potassium iodide. ( 28980537 )
2017
37
Disseminated Blastomycosis Mimicking Malignancy. ( 28813733 )
2017
38
Clinical Manifestations and Treatment of Blastomycosis. ( 28797487 )
2017
39
Fine needle aspiration cytology of acute blastomycosis thyroiditis. ( 28792123 )
2017
40
Invasive Trichophyton rubrum mimicking blastomycosis in a patient with solid organ transplant. ( 28627008 )
2017
41
Successful treatment of blastomycosis in a 7-year-old, female golden retriever dog on Manitoulin Island, Ontario. ( 28588338 )
2017
42
A retrospective study of anti-inflammatory use in dogs with pulmonary blastomycosis: 139 cases (2002-2012). ( 28561957 )
2017
43
An Atypical Case of Mucocutaneous Blastomycosis in the Greater Toronto Area. ( 28300442 )
2017
44
Blastomycosis during pregnancy: a case report and review of the literature. ( 28291633 )
2017
45
Disseminated Blastomycosis. ( 28177861 )
2017
46
Cutaneous blastomycosis and dermatophytic pseudomycetoma in a Persian cat from Bangkok, Thailand. ( 28116230 )
2017
47
Central Nervous System Blastomycosis in Children: A Case Report and Review of the Literature. ( 28033237 )
2017
48
Blastomycosis infection in an adolescent patient with Hodgkin lymphoma. ( 27663466 )
2017
49
Heterogeneity of blastomycosis-like pyoderma: A selection of cases from the last 35 years. ( 26776602 )
2017
50
Blastomycosis in Children: An Analysis of Clinical, Epidemiologic, and Genetic Features. ( 26703241 )
2017

Variations for Blastomycosis

Expression for Blastomycosis

Search GEO for disease gene expression data for Blastomycosis.

Pathways for Blastomycosis

GO Terms for Blastomycosis

Sources for Blastomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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