MCID: BLS002
MIFTS: 45

Blastomycosis

Categories: Infectious diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Blastomycosis

MalaCards integrated aliases for Blastomycosis:

Name: Blastomycosis 12 76 53 3 44 15 73
North American Blastomycosis 12 53
Gilchrist's Disease 12 53
Infection by Blastomyces Dermatitidis 12
Blastomyces Dermatitidis Infection 12
Blastomycotic Infection 12
Gilchrist Disease 73
Chicago Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12663
ICD10 33 B40 B40.9
ICD9CM 35 116 116.0
MeSH 44 D001759
NCIt 50 C34428
SNOMED-CT 68 10673008 69996000

Summaries for Blastomycosis

CDC : 3 Blastomycosis is an infection caused by a fungus called Blastomyces. The fungus lives in the environment, particularly in moist soil and in decomposing matter such as wood and leaves. Blastomyces mainly lives in areas of the United States and Canada surrounding the Ohio and Mississippi River valleys and the Great Lakes. People can get blastomycosis after breathing in the microscopic fungal spores from the air. Although most people who breathe in the spores don’t get sick, some of those who do may have flu-like symptoms, and the infection can sometimes become serious if it is not treated.

MalaCards based summary : Blastomycosis, also known as north american blastomycosis, is related to lobomycosis and paracoccidioidomycosis, and has symptoms including skin lesions, lung lesions and pleural thickening. An important gene associated with Blastomycosis is GC (GC, Vitamin D Binding Protein). The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and bone.

Disease Ontology : 12 A primary systemic mycosis that results in a systemic fungal infection, has material basis in Blastomyces dermatitidis, transmitted by airborne spores and has symptom skin lesions, has symptom lung lesions and has symptom pleural thickening.

NIH Rare Diseases : 53 Blastomycosis is a rare infection that may develop when people inhale a fungus called Blastomyces dermatitidis, a fungus that is found in moist soil, particularly where there is rotting vegetation. The fungus enters the body through the lungs, infecting them. The fungus then spreads to other areas of the body. The infection may affect the skin, bones and joints, and other areas. The disease usually affects people with weakened immune systems, such as those with HIV or who have had an organ transplant.

Wikipedia : 76 Blastomycosis (also known as "North American blastomycosis", "blastomycetic dermatitis", and... more...

Related Diseases for Blastomycosis

Graphical network of the top 20 diseases related to Blastomycosis:



Diseases related to Blastomycosis

Symptoms & Phenotypes for Blastomycosis

Symptoms:

12
  • skin lesions
  • lung lesions
  • pleural thickening

Drugs & Therapeutics for Blastomycosis

Drugs for Blastomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 4,Phase 3 1397-89-3 5280965 14956
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
3
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
4
deoxycholic acid Approved Phase 4 83-44-3 222528
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
6 Anti-Bacterial Agents Phase 4,Phase 3
7 Antiparasitic Agents Phase 4,Phase 3
8 Liposomal amphotericin B Phase 4,Phase 3
9 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
11 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
12 Antiprotozoal Agents Phase 4,Phase 3
13 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
14 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
15 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Amphotericin B, deoxycholate drug combination Phase 4
18
Itraconazole Approved, Investigational Phase 3,Phase 1,Phase 2,Early Phase 1 84625-61-6 55283
19
Hydroxyitraconazole Phase 3,Phase 1,Phase 2,Early Phase 1
20 Antibiotics, Antitubercular Phase 3
21 Pharmaceutical Solutions Phase 3,Early Phase 1
22
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
23 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
24 Cytochrome P-450 CYP2C19 Inhibitors Phase 2
25
Petrolatum Approved, Investigational Early Phase 1 8009-03-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Amphotericin-B and Voriconazole for Pulmonary Blastomycosis Suspended NCT02283905 Phase 4 amphotericin-B;voriconazole
2 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3 Itraconazole;Amphotericin B
3 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
4 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
5 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
6 Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Blastomycosis Dermatitidis Infection in Patients Not Infected With HIV and Complications Associated With Blastomycosis Dermatitidis Infection Completed NCT00001702
7 Topical Itraconazole in the Treatment of Basal Cell Carcinoma Recruiting NCT02120677 Early Phase 1 Itraconazole

Search NIH Clinical Center for Blastomycosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: blastomycosis

Genetic Tests for Blastomycosis

Anatomical Context for Blastomycosis

MalaCards organs/tissues related to Blastomycosis:

41
Lung, Skin, Bone, Testes, Thyroid, Prostate, B Cells

Publications for Blastomycosis

Articles related to Blastomycosis:

(show top 50) (show all 1089)
# Title Authors Year
1
Blastomycosis in Southern Saskatchewan 2000-2015: Unique presentations and disease characteristics. ( 29924358 )
2018
2
Primary Cutaneous Blastomycosis After Inoculation From A Woodworking Blade. ( 29169917 )
2018
3
Urinary tract blastomycosis diagnosed by urine cytology. ( 29573229 )
2018
4
Chronic Pulmonary Blastomycosis Mimicking Pulmonary Tuberculosis. ( 29547956 )
2018
5
Disseminated blastomycosis in a transplant patient. ( 29512289 )
2018
6
Blastomycosis-like Pyoderma Arising in Lichen Planus. ( 29462233 )
2018
7
Pyoderma Gangranosum-Like Blastomycosis. ( 29486592 )
2018
8
Central nervous system blastomycosis diagnosed using the MVistaAr Blastomyces quantitative antigen enzyme immunoassay test on cerebrospinal fluid: A case report and review of the literature. ( 29195765 )
2018
9
Erratum: Blastomycosis-like pyoderma: Novel use of potassium iodide. ( 29923506 )
2018
10
Cutaneous, Intranasal Blastomycosis Infection in Two Patients from Southern West Virginia: Diagnostic Dilemma. ( 29568716 )
2018
11
Disseminated Cutaneous Blastomycosis. ( 29972741 )
2018
12
Not just another Wisconsin case of blastomycosis. ( 29293961 )
2018
13
Epidemiology and Geographic Distribution of Blastomycosis, Histoplasmosis, and Coccidioidomycosis, Ontario, Canada, 1990-2015. ( 29912691 )
2018
14
Pulmonary blastomycosis presenting as primary lung cancer. ( 30021526 )
2018
15
Blastomycosis in a renal transplant recipient: Case of immune reconstitution inflammatory syndrome. ( 30023163 )
2018
16
25-Hydroxyvitamin D concentrations in dogs with naturally acquired blastomycosis. ( 30079575 )
2018
17
Incidental findings of blastomycosis lung nodules in five asymptomatic patients. ( 30094129 )
2018
18
Notes from the Field: Blastomycosis Cases Occurring Outside of Regions with Known Endemicity - New York, 2007-2017. ( 30260940 )
2018
19
Disseminated blastomycosis in a 36-year-old immunocompetent male from Chicago, IL. ( 30263127 )
2018
20
Blastomycosis-like pyoderma: a diagnostic as well as therapeutic challenge. ( 30428650 )
2018
21
Fatal blastomycosis after exogenous immunosuppression in a healthy gardener. ( 30450406 )
2018
22
Disseminated blastomycosis with cutaneous lesions mimicking tuberculosis. ( 30507461 )
2018
23
Potential clinical utility of ERC-2 yeast phase lysate antigen for antibody detection in dogs with blastomycosis. ( 30544205 )
2018
24
Blastomycosis ( 28723016 )
2017
25
Blastomycosis during pregnancy: a case report and review of the literature. ( 28291633 )
2017
26
A retrospective study of anti-inflammatory use in dogs with pulmonary blastomycosis: 139 cases (2002-2012). ( 28561957 )
2017
27
Fine needle aspiration cytology of acute blastomycosis thyroiditis. ( 28792123 )
2017
28
Successful treatment of blastomycosis in a 7-year-old, female golden retriever dog on Manitoulin Island, Ontario. ( 28588338 )
2017
29
Cutaneous blastomycosis and dermatophytic pseudomycetoma in a Persian cat from Bangkok, Thailand. ( 28116230 )
2017
30
Blastomycosis hospitalizations in northwestern Ontario: 2006-2015. ( 29770046 )
2017
31
Blastomycosis-like pyoderma: Novel use of potassium iodide. ( 28980537 )
2017
32
Clinical Manifestations and Treatment of Blastomycosis. ( 28797487 )
2017
33
Disseminated blastomycosis in a 57-year-old man working in construction. ( 29229716 )
2017
34
An Atypical Case of Mucocutaneous Blastomycosis in the Greater Toronto Area. ( 28300442 )
2017
35
Invasive Trichophyton rubrum mimicking blastomycosis in a patient with solid organ transplant. ( 28627008 )
2017
36
Disseminated Blastomycosis Mimicking Malignancy. ( 28813733 )
2017
37
Disseminated Blastomycosis. ( 28177861 )
2017
38
Blastomycosis-Like Pyoderma- A Rare Case Report. ( 27891438 )
2016
39
Diagnostic Delay and Antibiotic Overuse in Acute Pulmonary Blastomycosis. ( 27419155 )
2016
40
Central Nervous System Blastomycosis in Children - A Case Report and Review of the Literature. ( 28033237 )
2016
41
Multimodality imaging in cranial blastomycosis, a great mimicker: Case-based illustration with review of clinical and imaging findings. ( 27081235 )
2016
42
Blastomycosis. ( 26739607 )
2016
43
Blastomycosis of the nose: A case report. ( 27551850 )
2016
44
Reversal of Fortune: Central Nervous System Blastomycosis. ( 26477951 )
2016
45
SYSTEMIC BLASTOMYCOSIS IN A CAPTIVE RED RUFFED LEMUR (VARECIA RUBRA). ( 27691971 )
2016
46
Blastomycosis infection in an adolescent patient with Hodgkin lymphoma. ( 27663466 )
2016
47
Heterogeneity of blastomycosis-like pyoderma: A selection of cases from the last 35 years. ( 26776602 )
2016
48
Blastomycosis and Histoplasmosis in a Patient with Glioblastoma Receiving Temozolomide. ( 28806010 )
2016
49
Management and Outcomes of Acute Respiratory Distress Syndrome Caused by Blastomycosis: A Retrospective Case Series. ( 27149459 )
2016
50
Case 233: Blastomycosis. ( 27533292 )
2016

Variations for Blastomycosis

Expression for Blastomycosis

Search GEO for disease gene expression data for Blastomycosis.

Pathways for Blastomycosis

GO Terms for Blastomycosis

Cellular components related to Blastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.8 ADGRL3 CANX KCNB1

Biological processes related to Blastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein folding GO:0006457 8.62 CANX HSPE1

Molecular functions related to Blastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 8.96 ADGRL3 CANX
2 unfolded protein binding GO:0051082 8.62 CANX HSPE1

Sources for Blastomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....