MCID: BLS002
MIFTS: 40

Blastomycosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Blastomycosis

MalaCards integrated aliases for Blastomycosis:

Name: Blastomycosis 12 75 53 3 44 15 17 72 33
Blastomyces Dermatitidis Infection 12 3
North American Blastomycosis 12 53
Gilchrist's Disease 12 53
Infection by Blastomyces Dermatitidis 12
Blastomycotic Infection 12
Gilchrist Disease 72
Chicago Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12663
ICD9CM 35 116 116.0
MeSH 44 D001759
NCIt 50 C34428
SNOMED-CT 68 10673008 69996000
ICD10 33 B40 B40.9
UMLS 72 C0005716 C0005717

Summaries for Blastomycosis

CDC : 3 Blastomycosis is an infection caused by a fungus called Blastomyces. The fungus lives in the environment, particularly in moist soil and in decomposing matter such as wood and leaves. Blastomyces mainly lives in areas of the United States and Canada surrounding the Ohio and Mississippi River valleys and the Great Lakes. People can get blastomycosis after breathing in the microscopic fungal spores from the air. Although most people who breathe in the spores don't get sick, some of those who do may have flu-like symptoms, and the infection can sometimes become serious if it is not treated.

MalaCards based summary : Blastomycosis, also known as blastomyces dermatitidis infection, is related to lobomycosis and paracoccidioidomycosis, and has symptoms including skin lesions, lung lesions and pleural thickening. An important gene associated with Blastomycosis is GC (GC Vitamin D Binding Protein). The drugs Miconazole and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and bone.

Disease Ontology : 12 A primary systemic mycosis that results in a systemic fungal infection, has material basis in Blastomyces dermatitidis, transmitted by airborne spores and has symptom skin lesions, has symptom lung lesions and has symptom pleural thickening.

NIH Rare Diseases : 53 Blastomycosis is a rare infection that may develop when people inhale a fungus called Blastomyces dermatitidis, a fungus that is found in moist soil, particularly where there is rotting vegetation. The fungus enters the body through the lungs, infecting them. The fungus then spreads to other areas of the body. The infection may affect the skin, bones and joints, and other areas. The disease usually affects people with weakened immune systems, such as those with HIV or who have had an organ transplant.

Wikipedia : 75 Blastomycosis is a fungal infection caused by inhaling Blastomyces dermatitidis spores. If it involves... more...

Related Diseases for Blastomycosis

Diseases related to Blastomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 235)
# Related Disease Score Top Affiliating Genes
1 lobomycosis 12.4
2 paracoccidioidomycosis 11.7
3 chronic rhinitis 11.2
4 histoplasmosis 10.7
5 coccidioidomycosis 10.5
6 pyoderma 10.5
7 acute respiratory distress syndrome 10.4
8 osteomyelitis 10.4
9 respiratory failure 10.4
10 adult respiratory distress syndrome 10.3
11 bacterial pneumonia 10.3
12 sporotrichosis 10.3
13 keloid disorder 10.3
14 cryptococcosis 10.3
15 acquired immunodeficiency syndrome 10.3
16 mycobacterium tuberculosis 1 10.2
17 allergic hypersensitivity disease 10.2
18 actinomycosis 10.2
19 lung disease 10.2
20 meningitis 10.2
21 atrioventricular block 10.2
22 third-degree atrioventricular block 10.2
23 endocarditis 10.2
24 pericarditis 10.2
25 human immunodeficiency virus infectious disease 10.2
26 myocarditis 10.2
27 syncope 10.2
28 immune deficiency disease 10.2
29 pneumonia 10.2
30 aspergillosis 10.1
31 septic arthritis 10.1
32 sarcoidosis 1 10.1
33 human immunodeficiency virus type 1 10.1
34 pyoderma gangrenosum 10.1
35 47,xyy 10.1
36 leukemia, chronic lymphocytic 10.0
37 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
38 meningioma, radiation-induced 10.0
39 meningioma, familial 10.0
40 chronic meningitis 10.0
41 lymphocytic leukemia 10.0
42 spinal meningioma 10.0
43 epidural abscess 10.0
44 uveitis 10.0
45 panophthalmitis 10.0
46 lymphogranuloma venereum 10.0
47 toxic shock syndrome 10.0
48 pulmonary tuberculosis 10.0
49 keratoacanthoma 10.0
50 syphilis 10.0

Graphical network of the top 20 diseases related to Blastomycosis:



Diseases related to Blastomycosis

Symptoms & Phenotypes for Blastomycosis

Symptoms:

12
  • skin lesions
  • lung lesions
  • pleural thickening

Drugs & Therapeutics for Blastomycosis

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Itraconazole For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis. DB01167
2 Ketoconazole For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. DB01026

Drugs for Blastomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
2
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
3
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
4
deoxycholic acid Approved Phase 4 83-44-3 222528
5 14-alpha Demethylase Inhibitors Phase 4
6 Hormones Phase 4
7 Liposomal amphotericin B Phase 4
8 Cytochrome P-450 Enzyme Inhibitors Phase 4
9 Cytochrome P-450 CYP3A Inhibitors Phase 4
10 Antifungal Agents Phase 4
11 Steroid Synthesis Inhibitors Phase 4
12 Anti-Bacterial Agents Phase 4
13 Anti-Infective Agents Phase 4
14 Hormone Antagonists Phase 4
15 Antiparasitic Agents Phase 4
16 Antiprotozoal Agents Phase 4
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18 Amphotericin B, deoxycholate drug combination Phase 4
19
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
20 Antibiotics, Antitubercular Phase 3
21
Hydroxyitraconazole Phase 3
22 Pharmaceutical Solutions Phase 3
23
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
24 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
25 Cytochrome P-450 CYP2C19 Inhibitors Phase 2
26
Petrolatum Approved, Investigational Early Phase 1 8009-03-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Case Series of Continuously-infused Amphotericin-B and Follow-up Voriconazole Therapy for Severe Blastomycosis Pulmonary Infections Suspended NCT02283905 Phase 4 amphotericin-B;voriconazole
2 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3 Itraconazole;Amphotericin B
3 A Pharmacokinetic Study of JK1211 in Patients With Systemic Fungal Infection (SFI) and Patients With Febrile Neutropenia (FN) Suspected of Fungal Infection. Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
4 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
5 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
6 Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Blastomycosis Dermatitidis Infection in Patients Not Infected With HIV and Complications Associated With Blastomycosis Dermatitidis Infection Completed NCT00001702
7 A Pilot Study Investigating Antitumorigenic Potential of Topical Itraconazole in the Treatment of Basal Cell Carcinoma Completed NCT02120677 Early Phase 1 Itraconazole
8 Organ Transplant Infection Prevention and Detection Project 1.0; Cohort Study of Transplant Recipients at "Ultra-High" Risk for Invasive Fungal Infections Completed NCT00177801

Search NIH Clinical Center for Blastomycosis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Fluconazole
Itraconazole
Itraconazole
Ketoconazole
Ketoconazole

Cochrane evidence based reviews: blastomycosis

Genetic Tests for Blastomycosis

Anatomical Context for Blastomycosis

MalaCards organs/tissues related to Blastomycosis:

41
Lung, Skin, Bone, Testes, Prostate, Lymph Node, Brain

Publications for Blastomycosis

Articles related to Blastomycosis:

(show top 50) (show all 2073)
# Title Authors PMID Year
1
Emerging Fungal Infections: New Patients, New Patterns, and New Pathogens. 38
31330862 2019
2
Central Nervous System Infection with Other Endemic Mycoses: Rare Manifestation of Blastomycosis, Paracoccidioidomycosis, Talaromycosis, and Sporotrichosis. 38
31323746 2019
3
Dacryoadenitis Caused by Blastomycosis: A Case Report. 38
31365512 2019
4
Pleural Effusion in Pulmonary and Extrapulmonary Blastomycosis. 38
31266012 2019
5
Disseminated blastomycosis presenting as a retro-orbital mass. 38
31324667 2019
6
Disseminated blastomycosis in a patient on pembrolizumab for metastatic melanoma. 38
31312706 2019
7
Atypical blastomycosis in a pregnant woman. 38
30997389 2019
8
A Pregnant Woman with Anterior Chest Mass and Respiratory Failure: Blastomycosis in a Historically Nonendemic Area. 38
31307680 2019
9
Diagnosis of Fungal Infections: A Systematic Review and Meta-Analysis Supporting ATS Clinical Practice Guideline. 38
31219341 2019
10
Endemic Mycoses in Children. 38
31205246 2019
11
Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin-6 as a Potential Susceptibility Locus. 38
31213563 2019
12
Treatment of pulmonary blastomycosis with high-dose liposomal amphotericin B in a patient receiving extracorporeal membrane oxygenation. 38
31253662 2019
13
Apparent interference with extracorporeal membrane oxygenation by liposomal amphotericin B in a patient with disseminated blastomycosis receiving continuous renal replacement therapy. 38
30994894 2019
14
Lymphocutaneous Sporotrichosis of Face with Verrucous Lesions: A Case Report. 38
31149578 2019
15
Blastomycosis-like Pyoderma. 38
31037854 2019
16
Spinal blastomycosis: unusual musculoskeletal presentation with literature review. 38
31139922 2019
17
Mortality associated with Blastomyces dermatitidis infection: A systematic review of the literature and meta-analysis. 38
31111911 2019
18
Primary Laryngeal Blastomycosis: Diagnostic Challenges and Advances in a Rare Cause of Laryngitis. 38
31120608 2019
19
Imaging Patterns of Pediatric Pulmonary Blastomycosis. 38
30589384 2019
20
The Blastomycosis Bluff by Purpureocillium lilacinum. 38
30947843 2019
21
Veno-venous extracorporeal life support for blastomycosis-associated acute respiratory distress syndrome. 38
31027465 2019
22
Angioinvasive fungal infections impacting the skin: Background, epidemiology, and clinical presentation. 38
30102951 2019
23
Cryptococcal meningitis is a cause for cross-reactivity in cerebrospinal fluid assays for anti-Histoplasma, anti-Coccidioides and anti-Blastomyces antibodies. 38
30565753 2019
24
Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging. 38
30668231 2019
25
Endemic fungal infections in solid organ transplant recipients-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. 38
30924967 2019
26
Successful Treatment of Cutaneous Blastomycosis in a Renal Transplant Patient With BK Virus Infection: A Case Report. 38
30879591 2019
27
Disseminated Blastomycosis in a Teenager Presenting with Pleural Effusion and Splenomegaly. 38
30691698 2019
28
Mycobiome Sequencing and Analysis Applied to Fungal Community Profiling of the Lower Respiratory Tract During Fungal Pathogenesis. 38
30930884 2019
29
Novel canine anti-Coccidioides immunoglobulin G enzyme immunoassay aids in diagnosis of coccidioidomycosis in dogs. 38
30649403 2019
30
Disseminated blastomycosis with cutaneous lesions mimicking tuberculosis. 38
30507461 2018
31
Mandibular blastomycosis: A case report and review of the literature. 38
30775340 2018
32
Molecular detection of Blastomyces in an air sample from an outbreak associated residence. 38
30508124 2018
33
Potential clinical utility of ERC-2 yeast phase lysate antigen for antibody detection in dogs with blastomycosis. 38
30544205 2018
34
Pediatric primary cutaneous blastomycosis clinically responsive to itraconazole. 38
30566541 2018
35
Blastomycosis-like pyoderma: a diagnostic as well as therapeutic challenge. 38
30428650 2018
36
Fatal blastomycosis after exogenous immunosuppression in a healthy gardener. 38
30450406 2018
37
Blastomycosis in Southern Saskatchewan 2000-2015: Unique presentations and disease characteristics. 38
29924358 2018
38
Therapy of Non-Dermatophytic Mycoses in Animals. 38
30380772 2018
39
Safety and efficacy of chronic suppressive azole therapy for endemic fungal infections in solid organ transplant recipients. 38
29975443 2018
40
Disseminated blastomycosis in a 36-year-old immunocompetent male from Chicago, IL. 38
30263127 2018
41
Pyoderma Gangranosum-Like Blastomycosis. 38
29486592 2018
42
Incidental findings of blastomycosis lung nodules in five asymptomatic patients. 38
30094129 2018
43
25-Hydroxyvitamin D concentrations in dogs with naturally acquired blastomycosis. 38
30079575 2018
44
Blastomycosis in a renal transplant recipient: Case of immune reconstitution inflammatory syndrome. 38
30023163 2018
45
Notes from the Field: Blastomycosis Cases Occurring Outside of Regions with Known Endemicity - New York, 2007-2017. 38
30260940 2018
46
Endemic Mycoses in Solid Organ Transplant Recipients. 38
30146029 2018
47
Severe acute respiratory distress syndrome in a liver transplant patient. 38
29984146 2018
48
Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017. 38
30085265 2018
49
Urinary tract blastomycosis diagnosed by urine cytology. 38
29573229 2018
50
Opportunistic fungal infection in children and management. 38
29771758 2018

Variations for Blastomycosis

Expression for Blastomycosis

Search GEO for disease gene expression data for Blastomycosis.

Pathways for Blastomycosis

GO Terms for Blastomycosis

Biological processes related to Blastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 8.62 CD4 ADGRL3

Molecular functions related to Blastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.62 CD4 ADGRL3

Sources for Blastomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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