MCID: BLP006
MIFTS: 38

Blepharoconjunctivitis

Categories: Eye diseases

Aliases & Classifications for Blepharoconjunctivitis

MalaCards integrated aliases for Blepharoconjunctivitis:

Name: Blepharoconjunctivitis 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:2456
ICD9CM 34 372.2 372.20
NCIt 49 C34430
SNOMED-CT 67 68659002
ICD10 32 H10.5 H10.50
UMLS 71 C0005743

Summaries for Blepharoconjunctivitis

Disease Ontology : 12 A blepharitis that is characterized by the dual combination of conjunctivitis with blepharitis.

MalaCards based summary : Blepharoconjunctivitis is related to blepharitis and atopic keratoconjunctivitis. An important gene associated with Blepharoconjunctivitis is IL4 (Interleukin 4), and among its related pathways/superpathways are Allograft rejection and Bacterial infections in CF airways. The drugs Loteprednol and Tobramycin have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and breast, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 Conjunctivitis, also known as pink eye, is inflammation of the outermost layer of the white part of the... more...

Related Diseases for Blepharoconjunctivitis

Diseases related to Blepharoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
# Related Disease Score Top Affiliating Genes
1 blepharitis 30.8 IL4 CXCL8 CD4
2 atopic keratoconjunctivitis 30.7 RNASE3 IL4
3 allergic contact dermatitis 30.4 IL4 CXCL8 CD4
4 contact dermatitis 30.4 IL4 CXCL8 CD4
5 allergic conjunctivitis 30.3 RNASE3 IL4 CXCL8 CCL11
6 keratitis, hereditary 30.1 GJB6 CXCL8 CD4
7 uveitis 30.0 IL4 CXCL8 CCL11
8 seborrheic dermatitis 29.9 DOCK8 CXCL8 CD4
9 conjunctivitis 29.9 RNASE3 IL4 CXCL8 CCL24 CCL11
10 rhinitis 29.6 RNASE3 IL4 CXCL8 CCL11
11 vernal keratoconjunctivitis 29.5 RNASE3 IL4 CCL24 CCL11
12 eye disease 29.5 IL4 CXCL8 CD4 CCL11
13 papillary conjunctivitis 29.4 IL4 CXCL8 CCL24 CCL11
14 keratoconjunctivitis 29.4 RNASE3 IL4 CXCL8 CCL24 CCL11
15 hypereosinophilic syndrome 28.9 RNASE3 IL4 CXCL8 CCL24 CCL11
16 dermatitis 28.9 RNASE3 IL4 CXCL8 CMA1 CCL11
17 allergic rhinitis 28.9 RNASE3 IL4 CXCL8 CCL24 CCL11
18 chronic conjunctivitis 28.3 RNASE3 IL4 CXCL8 CMA1 CD4 CCL11
19 dermatitis, atopic 27.9 RNASE3 IL4 CXCL8 CMA1 CD4 CCL24
20 angular blepharoconjunctivitis 12.6
21 contact blepharoconjunctivitis 12.4
22 metal allergy 10.4 IL4 CD4
23 nickel allergic contact dermatitis 10.4 IL4 CD4
24 trichinosis 10.4 IL4 CD4
25 mikulicz disease 10.4 IL4 CD4
26 abacavir allergy 10.4 CD4 CCL11
27 corticosteroid allergy 10.4 IL4 CD4
28 autoimmune vasculitis 10.4 IL4 CD4
29 herpes simplex 10.4
30 chronic meningitis 10.4 CD4 CCL11
31 tuberculoid leprosy 10.4 IL4 CD4
32 hyper ige syndrome 10.4 IL4 DOCK8
33 taeniasis 10.4 IL4 CD4
34 tick infestation 10.4 IL4 CD4
35 suppurative lymphadenitis 10.4 DOCK8 CD4
36 common wart 10.3 DOCK8 CD4
37 vernal conjunctivitis 10.3 RNASE3 IL4
38 cough variant asthma 10.3 RNASE3 IL4
39 adhesive otitis media 10.3 RNASE3 CCL11
40 mastoiditis 10.3 DOCK8 CD4
41 endomyocardial fibrosis 10.3 RNASE3 IL4
42 lung abscess 10.3 DOCK8 CD4
43 strongyloidiasis 10.3 CD4 CCL11
44 hyper ige recurrent infection syndrome 1 10.3 DOCK8 CD4
45 pemphigoid gestationis 10.3 RNASE3 CCL11
46 ocular cicatricial pemphigoid 10.3 RNASE3 IL4
47 rosacea 10.3
48 elephantiasis 10.3 RNASE3 IL4
49 nut allergy 10.3 IL4 CD4
50 chronic rhinitis 10.3 RNASE3 IL4

Comorbidity relations with Blepharoconjunctivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Blepharoconjunctivitis:



Diseases related to Blepharoconjunctivitis

Symptoms & Phenotypes for Blepharoconjunctivitis

GenomeRNAi Phenotypes related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.44 IL4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.44 CCL24
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.44 CCL24 IL4 PKD2L1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.44 CCL24
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.44 PKD2L1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.44 IL4
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.44 IL4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.44 CCL24
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.44 IL4
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.44 IL4
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-94 9.44 CCL24

Drugs & Therapeutics for Blepharoconjunctivitis

Drugs for Blepharoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved, Experimental Phase 4 129260-79-3, 82034-46-6 444025 9865442
2
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
3 Anti-Bacterial Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Anti-Allergic Agents Phase 4
6 Pharmaceutical Solutions Phase 2
7 Ophthalmic Solutions Phase 2
8
Tea tree oil Approved Phase 1
9 Tea Phase 1
10 Tea Tree Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Zylet vs Lotemax, Tobramycin and Vehicle in Pediatric Blepharoconjunctivitis Completed NCT00705159 Phase 4 loteprednol etabonate and tobramycin;loteprednol etabonate;Tobramycin;Vehicle of Zylet
2 A Randomized, Double-Masked, Parallel-Group, Comparative Study to Evaluate the Clinical and Anti-Microbial Efficacy and Safety of AzaSite Plus Compared to AzaSite Alone and Dexamethasone Alone in the Treatment of Subjects With Blepharoconjunctivitis Completed NCT00578955 Phase 3 1% Azithromycin and 0.1% Dexamethasone;1% Azithromycin;0.1% Dexamethasone
3 A Randomized, Double-Masked, Parallel-Group, Comparative Study to Evaluate the Clinical and Anti-Microbial Efficacy and Safety of AzaSite Plus Compared to AzaSite Alone and Dexamethasone Alone in the Treatment of Subjects With Blepharoconjunctivitis Withdrawn NCT00754949 Phase 3 1% Azithromycin and 0.1% Dexamethasone;1% Azithromycin;0.1% Dexamethasone
4 A Single-Center, Open-Label Study to Characterize Eyelid Margin Erythema, Markers of Clinical Inflammation and Levels of Inflammatory Mediators in the Lid Margins and Conjunctivae of Untreated Healthy Volunteers and Subjects Diagnosed With Posterior Blepharoconjunctivitis Following Dosing With Azithromycin Ophthalmic Solution, 1% for Four Weeks Terminated NCT01220258 Phase 2 Azithromycin ophthalmic solution, 1%
5 Safety and Efficacy of Single-use Terpinen-4-ol Pads for Treating Ocular Mites A Randomized Clinical Trial Completed NCT01647217 Phase 1 Terpinen-4-ol

Search NIH Clinical Center for Blepharoconjunctivitis

Genetic Tests for Blepharoconjunctivitis

Anatomical Context for Blepharoconjunctivitis

MalaCards organs/tissues related to Blepharoconjunctivitis:

40
Eye, T Cells, Breast, Skin, Lung, B Cells, Testes

Publications for Blepharoconjunctivitis

Articles related to Blepharoconjunctivitis:

(show top 50) (show all 299)
# Title Authors PMID Year
1
Dupilumab-Associated Conjunctivitis in Patients With Atopic Dermatitis. 61
31985517 2020
2
Dupilumab-associated blepharoconjunctivitis. 61
31535057 2019
3
[Corneal perforation due to 'lost' contact lenses]. 61
31647622 2019
4
Dupilumab-induced ocular surface disease (DIOSD) in patients with atopic dermatitis: clinical presentation, risk factors for development and outcomes of treatment with tacrolimus ointment. 61
31554632 2019
5
Outbreak of Systemic Avian Pox in Canaries (Serinus canaria domestica) Associated with the B1 Subgroup of Avian Pox Viruses. 61
31967439 2019
6
Diagnosing and managing allergic conjunctivitis in childhood: The allergist's perspective. 61
30742722 2019
7
Blepharoconjunctivitis Secondary to Dupilumab Successfully Treated with Itraconazole. 61
31045929 2019
8
[Application of corticosteroid eye drops for allergic eye diseases in children]. 61
30798620 2019
9
[Ocular symptoms associated with dupilumab in atopic dermatitis]. 61
30945835 2019
10
[Rehabilitation of Anophthalmic Patients with Prosthetic Eyes in Germany Today - Supply Possibilities, Daily Use, Complications and Psychological Aspects]. 61
30567009 2019
11
Cicatrizing Blepharoconjunctivitis Occurring During Dupilumab Treatment and a Proposed Algorithm for Its Management. 61
30347029 2018
12
Significant correlation between meibomian gland dysfunction and keratitis in young patients with Demodex brevis infestation. 61
29055903 2018
13
Ocular bacterial infections and antibiotic resistance patterns in patients attending Gondar Teaching Hospital, Northwest Ethiopia. 61
30119696 2018
14
Management of Neonatal Herpes Simplex Infection: A Rare Case of Blepharoconjunctivitis and Concurrent Epithelial and Stromal Keratitis. 61
27849421 2018
15
Effectiveness of 0.1% topical salicylic acid on blepharoconjunctivitis affecting glaucoma patients treated with topical prostaglandin analogues: a prospective randomized trial. 61
30588426 2018
16
Demodex blepharitis: clinical perspectives. 61
30214343 2018
17
Phthirus pubis Infestation of the Eyelids Presenting as Chronic Blepharoconjunctivitis in a 6-Year-Old Girl: A Case Report. 61
29643778 2018
18
Ocular bacterial infections at Quiha Ophthalmic Hospital, Northern Ethiopia: an evaluation according to the risk factors and the antimicrobial susceptibility of bacterial isolates. 61
28292273 2017
19
Topical treatments for blepharokeratoconjunctivitis in children. 61
28170093 2017
20
A 10-Year Review of Ocular Methicillin-Resistant Staphylococcus aureus Infections: Epidemiology, Clinical Features, and Treatment. 61
27755189 2017
21
[Ophthalmoferon efficacy in the treatment of children with chronic blepharoconjunctivitis]. 61
29165413 2017
22
Side effects of retinoid therapy on the quality of vision. 61
27749251 2016
23
Development of Herpes Simplex Virus Infectious Epithelial Keratitis During Oral Acyclovir Therapy and Response to Topical Antivirals. 61
26989961 2016
24
The Pathology of Aging 129S6/SvEvTac Mice. 61
26467077 2016
25
[Ocular prosthetics. Fitting, daily use and complications]. 61
26160105 2016
26
[Eye lid hygiene in chronic allergic blepharoconjunctivitis patients before laser refractive surgery]. 61
27911432 2016
27
Rosacea Blepharoconjunctivitis Treated with a Novel Preparation of Dilute Povidone Iodine and Dimethylsulfoxide: a Case Report and Review of the Literature. 61
26525679 2015
28
Actinomycosis of eye: Forgotten but not uncommon. 61
26057988 2015
29
Investigation of the relationship between the onset of arthritis and uveitis in genetically predisposed SKG mice. 61
26286534 2015
30
Blepharoconjunctivitis and an unusual location of metastatic breast carcinoma. 61
25547423 2015
31
Treatment of Phthiriasis Palpebrarum and Crab Louse: Petrolatum Jelly and 1% Permethrin Shampoo. 61
26451147 2015
32
Allergic contact dermatitis presenting as severe and persistent blepharoconjunctivitis and centrofacial oedema after dyeing of eyelashes. 61
25345792 2014
33
A rare cause of blepharoconjunctivitis: Phthiriasis palpebrarum. 61
25385926 2014
34
Allergic blepharoconjunctivitis caused by acrylates promotes allergic rhinitis response. 61
25155084 2014
35
[Treatment of chronic allergic blepharoconjunctivitis]. 61
25711068 2014
36
Bilateral blepharoconjunctivitis as the presenting sign of disseminated herpes simplex 1 infection in a preterm neonate. 61
24784884 2014
37
Phthiriasis palpebrarum misdiagnosed as allergic blepharoconjunctivitis in a 6-year-old girl. 61
24909484 2014
38
Long-term safety of topical pimecrolimus and topical tacrolimus in atopic blepharoconjunctivitis. 61
24500107 2014
39
Beneficial IFN-α treatment of tumorous herpes simplex blepharoconjunctivitis in dedicator of cytokinesis 8 deficiency. 61
24698314 2014
40
[Demodex folliculorum: diagnosis and therapy today]. 61
24658861 2014
41
[Use of cyclosporine 0.05% in various ocular surface disorders]. 61
24864503 2014
42
CHD7 deficiency in "Looper", a new mouse model of CHARGE syndrome, results in ossicle malformation, otosclerosis and hearing impairment. 61
24840056 2014
43
[Sebaceous carcinoma of the eyelid--two case reports]. 61
25345292 2014
44
Phthriasis palpebrarum can resemble tick larva infestation in an eyelid. 61
23993722 2013
45
[Ocular rosacea]. 61
23824155 2013
46
Oral acyclovir for herpes simplex blepharoconjunctivitis in children. 61
23732061 2013
47
[Inveterate squamous cell carcinoma of the upper eyelid: a case report]. 61
23868639 2013
48
Observational prospective cohort study of patients with newly-diagnosed ocular sebaceous carcinoma. 61
23117971 2013
49
A Phase III clinical study to evaluate the efficacy of combined azithromycin and dexamethasone in the treatment of blepharoconjunctivitis. 61
24250221 2013
50
Pediatric herpes simplex of the anterior segment: characteristics, treatment, and outcomes. 61
22796308 2012

Variations for Blepharoconjunctivitis

Expression for Blepharoconjunctivitis

Search GEO for disease gene expression data for Blepharoconjunctivitis.

Pathways for Blepharoconjunctivitis

Pathways related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.29 RNASE3 IL4 CXCL8 CD4 CCL11
2
Show member pathways
11.76 IL4 CXCL8 CCL11
3 11.55 IL4 CXCL8 CCL11
4 11.28 IL4 CCL24 CCL11
5 10.87 IL4 CD4
6 10.79 IL4 CD4 CCL11
7 10.72 IL4 CXCL8 CMA1 CCL11

GO Terms for Blepharoconjunctivitis

Cellular components related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 RNASE3 MMP8 IL4 CXCL8 CMA1 CCL24
2 extracellular region GO:0005576 9.23 RNASE3 MMP8 IL4 EDA CXCL8 CMA1

Biological processes related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 IL4 CXCL8 CD4 CCL11
2 chemotaxis GO:0006935 9.63 CXCL8 CCL24 CCL11
3 cellular response to tumor necrosis factor GO:0071356 9.58 CXCL8 CCL24 CCL11
4 neutrophil chemotaxis GO:0030593 9.5 CXCL8 CCL24 CCL11
5 eosinophil chemotaxis GO:0048245 9.43 CCL24 CCL11
6 cellular response to interleukin-1 GO:0071347 9.43 CXCL8 CCL24 CCL11
7 chemokine-mediated signaling pathway GO:0070098 9.33 CXCL8 CCL24 CCL11
8 positive regulation of angiogenesis GO:0045766 9.26 CXCL8 CMA1 CCL24 CCL11
9 immune response GO:0006955 9.1 IL4 EDA CXCL8 CD4 CCL24 CCL11

Molecular functions related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 IL4 CXCL8 CCL24 CCL11
2 chemokine activity GO:0008009 9.13 CXCL8 CCL24 CCL11
3 CCR3 chemokine receptor binding GO:0031728 8.62 CCL24 CCL11

Sources for Blepharoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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