MCID: BLP006
MIFTS: 36

Blepharoconjunctivitis

Categories: Eye diseases

Aliases & Classifications for Blepharoconjunctivitis

MalaCards integrated aliases for Blepharoconjunctivitis:

Name: Blepharoconjunctivitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2456
ICD10 33 H10.5 H10.50
ICD9CM 35 372.2 372.20
NCIt 50 C34430
SNOMED-CT 68 68659002
UMLS 73 C0005743

Summaries for Blepharoconjunctivitis

Disease Ontology : 12 A blepharitis that is characterized by the dual combination of conjunctivitis with blepharitis.

MalaCards based summary : Blepharoconjunctivitis is related to blepharitis and dermatitis. An important gene associated with Blepharoconjunctivitis is IL4 (Interleukin 4), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Matrix Metalloproteinases. The drugs Loteprednol and Tobramycin have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and testes.

Wikipedia : 76 Conjunctivitis, also known as pink eye, is inflammation of the outermost layer of the white part of the... more...

Related Diseases for Blepharoconjunctivitis

Diseases related to Blepharoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 blepharitis 30.0 CCL11 NIPAL4 SHE
2 dermatitis 29.8 CCL11 CMA1 IL4
3 conjunctivitis 29.8 CCL11 IL4 RNASE3
4 rhinitis 29.7 CCL11 IL4 RNASE3
5 allergic rhinitis 29.7 CCL11 IL4 RNASE3
6 angular blepharoconjunctivitis 12.5
7 contact blepharoconjunctivitis 12.2
8 herpes simplex 10.3
9 papillary conjunctivitis 10.1 CCL11 IL4
10 cough variant asthma 10.1 IL4 RNASE3
11 atopic keratoconjunctivitis 10.1 IL4 RNASE3
12 angiostrongyliasis 10.1 CCL11 IL4
13 intrinsic asthma 10.1 IL4 RNASE3
14 inflammatory bowel disease 4 10.1 IL4 RNASE3
15 latex allergy 10.1 IL4 RNASE3
16 eosinophilic meningitis 10.1 CCL11 IL4
17 eosinophilic gastritis 10.1 CCL11 IL4
18 aggressive periodontitis 10.1 IL4 MMP8
19 urinary schistosomiasis 10.1 IL4 RNASE3
20 schistosomiasis 10.1 IL4 RNASE3
21 folliculitis 10.1 CCL11 IL4
22 periodontitis 10.1 IL4 MMP8
23 strongyloidiasis 10.1 CCL11 SHE
24 milk allergy 10.1 IL4 RNASE3
25 ocular cicatricial pemphigoid 10.1 IL4 RNASE3
26 lymphoma 10.0
27 contact dermatitis 10.0
28 allergic contact dermatitis 10.0
29 parasitic helminthiasis infectious disease 10.0 IL4 RNASE3
30 gingivitis 10.0 IL4 MMP8
31 ige responsiveness, atopic 10.0 IL4 RNASE3
32 eosinophilic gastroenteritis 10.0 CCL11 RNASE3
33 chronic eosinophilic pneumonia 10.0 CCL11 RNASE3
34 eosinophilic pneumonia 10.0 CCL11 RNASE3
35 food allergy 10.0 IL4 RNASE3
36 common cold 10.0 CCL11 RNASE3
37 leukocyte disease 10.0 CCL11 IL4
38 giant papillary conjunctivitis 9.9 CCL11 IL4 RNASE3
39 cold urticaria 9.9 CMA1 RNASE3
40 kimura disease 9.9 CCL11 IL4 RNASE3
41 vernal keratoconjunctivitis 9.9 CCL11 IL4 RNASE3
42 urticaria 9.9 CMA1 RNASE3
43 keratoconjunctivitis 9.9 CCL11 IL4 RNASE3
44 conjunctival disease 9.9 CCL11 IL4 RNASE3
45 pulmonary eosinophilia 9.9 CCL11 IL4 RNASE3
46 onchocerciasis 9.9 CCL11 IL4 RNASE3
47 allergic conjunctivitis 9.9 CCL11 IL4 RNASE3
48 nasal cavity disease 9.9 CCL11 IL4 RNASE3
49 nose disease 9.9 CCL11 IL4 RNASE3
50 respiratory allergy 9.9 CCL11 IL4 RNASE3

Comorbidity relations with Blepharoconjunctivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Ischemic Heart Disease

Graphical network of the top 20 diseases related to Blepharoconjunctivitis:



Diseases related to Blepharoconjunctivitis

Symptoms & Phenotypes for Blepharoconjunctivitis

Drugs & Therapeutics for Blepharoconjunctivitis

Drugs for Blepharoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 9865442 444025
2
Tobramycin Approved, Investigational Phase 4 32986-56-4 36294 5496
3 Anti-Allergic Agents Phase 4
4 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
7
Azithromycin Approved Phase 3,Phase 2 83905-01-5 55185 447043
8
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
9 Gastrointestinal Agents Phase 3
10 glucocorticoids Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
12 Antineoplastic Agents, Hormonal Phase 3
13 Hormone Antagonists Phase 3
14 Antiemetics Phase 3
15 Autonomic Agents Phase 3
16 BB 1101 Phase 3
17 Hormones Phase 3
18
protease inhibitors Phase 3
19 Anti-Inflammatory Agents Phase 3
20 HIV Protease Inhibitors Phase 3
21 Peripheral Nervous System Agents Phase 3
22 Pharmaceutical Solutions Phase 2
23 Ophthalmic Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Zylet vs Lotemax, Tobramycin and Vehicle in Pediatric Blepharoconjunctivitis Completed NCT00705159 Phase 4 loteprednol etabonate and tobramycin;loteprednol etabonate;Tobramycin;Vehicle of Zylet
2 Comparative Study of AzaSite Plus Compared to AzaSite Alone and Dexamethasone Alone to Treat Subjects With Blepharoconjunctivitis Completed NCT00578955 Phase 3 1% Azithromycin and 0.1% Dexamethasone;1% Azithromycin;0.1% Dexamethasone
3 Comparative Study of AzaSite Plus Compared to AzaSite Alone and Dexamethasone Alone to Treat Subjects With Blepharoconjunctivitis Withdrawn NCT00754949 Phase 3 1% Azithromycin and 0.1% Dexamethasone;1% Azithromycin;0.1% Dexamethasone
4 A Four Week, Open-Label Study of Azithromycin Ophthalmic Solution, 1% (P08641) Terminated NCT01220258 Phase 2 Azithromycin ophthalmic solution, 1%

Search NIH Clinical Center for Blepharoconjunctivitis

Genetic Tests for Blepharoconjunctivitis

Anatomical Context for Blepharoconjunctivitis

MalaCards organs/tissues related to Blepharoconjunctivitis:

41
Eye, T Cells, Testes, Lymph Node, Skin

Publications for Blepharoconjunctivitis

Articles related to Blepharoconjunctivitis:

(show top 50) (show all 95)
# Title Authors Year
1
<i>Phthirus pubis</i> Infestation of the Eyelids Presenting as Chronic Blepharoconjunctivitis in a 6-Year-Old Girl: A Case Report. ( 29643778 )
2018
2
Cicatrizing Blepharoconjunctivitis Occurring During Dupilumab Treatment and a Proposed Algorithm for Its Management. ( 30347029 )
2018
3
Management of Neonatal Herpes Simplex Infection: A Rare Case of Blepharoconjunctivitis and Concurrent Epithelial and Stromal Keratitis. ( 27849421 )
2016
4
Blepharoconjunctivitis and an unusual location of metastatic breast carcinoma. ( 25547423 )
2015
5
Rosacea Blepharoconjunctivitis Treated with a Novel Preparation of Dilute Povidone Iodine and Dimethylsulfoxide: a Case Report and Review of the Literature. ( 26525679 )
2015
6
Bilateral blepharoconjunctivitis as the presenting sign of disseminated herpes simplex 1 infection in a preterm neonate. ( 24784884 )
2014
7
Beneficial IFN-I+ treatment of tumorous herpes simplex blepharoconjunctivitis in dedicator of cytokinesis 8 deficiency. ( 24698314 )
2014
8
Allergic blepharoconjunctivitis caused by acrylates promotes allergic rhinitis response. ( 25155084 )
2014
9
Long-term safety of topical pimecrolimus and topical tacrolimus in atopic blepharoconjunctivitis. ( 24500107 )
2014
10
Phthiriasis palpebrarum misdiagnosed as allergic blepharoconjunctivitis in a 6-year-old girl. ( 24909484 )
2014
11
A rare cause of blepharoconjunctivitis: Phthiriasis palpebrarum. ( 25385926 )
2014
12
Allergic contact dermatitis presenting as severe and persistent blepharoconjunctivitis and centrofacial oedema after dyeing of eyelashes. ( 25345792 )
2014
13
A Phase III clinical study to evaluate the efficacy of combined azithromycin and dexamethasone in the treatment of blepharoconjunctivitis. ( 24250221 )
2013
14
Oral acyclovir for herpes simplex blepharoconjunctivitis in children. ( 23732061 )
2013
15
Contact blepharoconjunctivitis due to black henna--a case report. ( 22492286 )
2012
16
Treatment of refractory atopic blepharoconjunctivitis with topical tacrolimus 0.03% dermatologic ointment. ( 22103968 )
2012
17
Evaluation of clinical efficacy and safety of tobramycin/dexamethasone ophthalmic suspension 0.3%/0.05% compared to azithromycin ophthalmic solution 1% in the treatment of moderate to severe acute blepharitis/blepharoconjunctivitis. ( 21138337 )
2011
18
Tacrolimus ointment in atopic blepharoconjunctivitis does not seem to elevate intraocular pressure. ( 20064110 )
2011
19
Ocular demodicosis as a potential cause of pediatric blepharoconjunctivitis. ( 20847679 )
2010
20
Severe allergic blepharoconjunctivitis after eyelash colouring. ( 19300467 )
2010
21
Long-lasting allergic contact blepharoconjunctivitis to phenylephrine eyedrops. ( 19254293 )
2009
22
Sinonasal lymphoma masquerading as persistent blepharoconjunctivitis. ( 19229743 )
2009
23
A prospective study determining the efficacy of topical 0.5% levofloxacin on bacterial flora of patients with chronic blepharoconjunctivitis. ( 19205719 )
2009
24
Elevated expression and activation of matrix metalloproteinase 8 in tear fluid in atopic blepharoconjunctivitis. ( 18362656 )
2008
25
Necrotizing pseudomonas blepharoconjunctivitis. ( 17510872 )
2007
26
Effect of 0.03% tacrolimus ointment on conjunctival cytology in patients with severe atopic blepharoconjunctivitis: a retrospective study. ( 16965503 )
2006
27
Genetic background determines susceptibility to experimental immune-mediated blepharoconjunctivitis: comparison of Balb/c and C57BL/6 mice. ( 16102751 )
2006
28
Severe blepharoconjunctivitis induced by a peeling mask containing trichloroacetic acid. ( 16019688 )
2005
29
Discoid lupus erythematosus masquerading as chronic blepharoconjunctivitis. ( 15878050 )
2005
30
Dissection of antigen-specific humoral and cellular immune responses for the development of experimental immune-mediated blepharoconjunctivitis in C57BL/6 mice. ( 15823916 )
2005
31
Suppression of macrophage infiltration into the conjunctiva by clodronate liposomes in experimental immune-mediated blepharoconjunctivitis. ( 15893479 )
2005
32
Analysis of Ag-presenting cells in the conjunctiva during the development of experimental immune-mediated blepharoconjunctivitis. ( 15590473 )
2004
33
Artificial tears inhibit the development of experimental immune-mediated blepharoconjunctivitis. ( 15592776 )
2004
34
Group IIA phospholipase A2 content of tears in patients with atopic blepharoconjunctivitis. ( 15592866 )
2004
35
Phenotypic changes and inflammatory cell distribution in the cornea during development of experimental immune-mediated blepharoconjunctivitis. ( 15295657 )
2004
36
Detection of antigen-specific T cells in experimental immune-mediated blepharoconjunctivitis in DO11.10 T cell receptor transgenic mice. ( 14734856 )
2004
37
Ocular involvement in cutaneous leishmaniasis four cases with blepharoconjunctivitis. ( 15117121 )
2004
38
Mast-cell activation augments the late phase reaction in experimental immune-mediated blepharoconjunctivitis. ( 12682842 )
2003
39
Ag-specific recognition, activation, and effector function of T cells in the conjunctiva with experimental immune-mediated blepharoconjunctivitis. ( 14507881 )
2003
40
Severe allergic blepharoconjunctivitis induced by a dye for eyelashes and eyebrows. ( 14533035 )
2003
41
Phthiriasis palpebrarum: an unusual blepharoconjunctivitis. ( 12523816 )
2002
42
Suppression of experimental immune-mediated blepharoconjunctivitis in Brown Norway rats by topical application of FK506. ( 11931080 )
2002
43
Exertion of the suppressive effects of IFN-gamma on experimental immune mediated blepharoconjunctivitis in Brown Norway rats during the induction phase but not the effector phase. ( 12234900 )
2002
44
Allergic contact blepharoconjunctivitis from dorzolamide. ( 11683843 )
2001
45
Effects of IL-4 and IL-12 on experimental immune-mediated blepharoconjunctivitis in Brown Norway rats. ( 11012614 )
2000
46
Epitheliotropic lymphoma (mycosis fungoides) presenting as blepharoconjunctivitis in an Irish setter. ( 10976628 )
2000
47
Experimental immune-mediated blepharoconjunctivitis in rats induced by immunization with ragweed pollen. ( 10853935 )
2000
48
Allergic contact blepharoconjunctivitis due to phenylephrine eye drops. ( 10212859 )
1999
49
Inhibitory effects of FK506 on the development of experimental allergic/immune-mediated blepharoconjunctivitis in Lewis rats by systemic but not by topical administration. ( 10333108 )
1999
50
Genetic background determines the nature of immune responses and experimental immune-mediated blepharoconjunctivitis (EC). ( 10223655 )
1999

Variations for Blepharoconjunctivitis

Expression for Blepharoconjunctivitis

Search GEO for disease gene expression data for Blepharoconjunctivitis.

Pathways for Blepharoconjunctivitis

Pathways related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.43 CCL11 IL4
2
Show member pathways
11.32 CMA1 MMP8
3 11.11 CCL11 IL4
4 10.96 CCL11 IL4
5 10.62 CCL11 IL4
6 10.6 CCL11 CMA1 IL4

GO Terms for Blepharoconjunctivitis

Cellular components related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CCL11 CMA1 IL4 MMP8 RNASE3
2 extracellular space GO:0005615 9.02 CCL11 CMA1 IL4 MMP8 RNASE3

Biological processes related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 8.62 CMA1 MMP8

Molecular functions related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 CMA1 MMP8

Sources for Blepharoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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