MCID: BLP006
MIFTS: 36

Blepharoconjunctivitis

Categories: Eye diseases

Aliases & Classifications for Blepharoconjunctivitis

MalaCards integrated aliases for Blepharoconjunctivitis:

Name: Blepharoconjunctivitis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2456
ICD9CM 36 372.2 372.20
NCIt 51 C34430
SNOMED-CT 69 68659002
ICD10 34 H10.5 H10.50
UMLS 74 C0005743

Summaries for Blepharoconjunctivitis

Disease Ontology : 12 A blepharitis that is characterized by the dual combination of conjunctivitis with blepharitis.

MalaCards based summary : Blepharoconjunctivitis is related to blepharitis and dermatitis. An important gene associated with Blepharoconjunctivitis is IL4 (Interleukin 4), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Matrix Metalloproteinases. The drugs Loteprednol and Tobramycin have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and testes.

Wikipedia : 77 Conjunctivitis, also known as pink eye, is inflammation of the outermost layer of the white part of the... more...

Related Diseases for Blepharoconjunctivitis

Diseases related to Blepharoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 blepharitis 30.4 CCL11 SHE
2 dermatitis 29.9 CCL11 CMA1 IL4
3 conjunctivitis 29.7 CCL11 IL4 RNASE3
4 rhinitis 29.7 CCL11 IL4 RNASE3
5 allergic rhinitis 29.7 CCL11 IL4 RNASE3
6 angular blepharoconjunctivitis 12.5
7 contact blepharoconjunctivitis 12.3
8 herpes simplex 10.3
9 papillary conjunctivitis 10.2 CCL11 IL4
10 cough variant asthma 10.2 IL4 RNASE3
11 inflammatory bowel disease 4 10.2 IL4 RNASE3
12 atopic keratoconjunctivitis 10.1 IL4 RNASE3
13 angiostrongyliasis 10.1 CCL11 IL4
14 intrinsic asthma 10.1 IL4 RNASE3
15 latex allergy 10.1 IL4 RNASE3
16 eosinophilic meningitis 10.1 CCL11 IL4
17 eosinophilic gastritis 10.1 CCL11 IL4
18 urinary schistosomiasis 10.1 IL4 RNASE3
19 schistosomiasis 10.1 IL4 RNASE3
20 aggressive periodontitis 10.1 IL4 MMP8
21 folliculitis 10.1 CCL11 IL4
22 strongyloidiasis 10.1 CCL11 SHE
23 milk allergy 10.1 IL4 RNASE3
24 periodontitis 10.1 IL4 MMP8
25 ocular cicatricial pemphigoid 10.1 IL4 RNASE3
26 lymphoma 10.1
27 contact dermatitis 10.1
28 allergic contact dermatitis 10.1
29 parasitic helminthiasis infectious disease 10.1 IL4 RNASE3
30 eosinophilic gastroenteritis 10.1 CCL11 RNASE3
31 ige responsiveness, atopic 10.0 IL4 RNASE3
32 gingivitis 10.0 IL4 MMP8
33 chronic eosinophilic pneumonia 10.0 CCL11 RNASE3
34 eosinophilic pneumonia 10.0 CCL11 RNASE3
35 cold urticaria 10.0 CMA1 RNASE3
36 urticaria 10.0 CMA1 RNASE3
37 food allergy 10.0 IL4 RNASE3
38 common cold 10.0 CCL11 RNASE3
39 leukocyte disease 9.9 CCL11 IL4
40 mycosis fungoides 9.9
41 acute lymphocytic leukemia 9.9
42 cutaneous leishmaniasis 9.9
43 leukemia 9.9
44 lymphocytic leukemia 9.9
45 entropion 9.9
46 ichthyosis 9.9
47 lupus erythematosus 9.9
48 rosacea 9.9
49 leishmaniasis 9.9
50 bacterial conjunctivitis 9.9

Comorbidity relations with Blepharoconjunctivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Ischemic Heart Disease

Graphical network of the top 20 diseases related to Blepharoconjunctivitis:



Diseases related to Blepharoconjunctivitis

Symptoms & Phenotypes for Blepharoconjunctivitis

Drugs & Therapeutics for Blepharoconjunctivitis

Drugs for Blepharoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 444025 9865442
2
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
3 Anti-Allergic Agents Phase 4
4 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2
6
Azithromycin Approved Phase 3,Phase 2 83905-01-5 55185 447043
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
8
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
9 Gastrointestinal Agents Phase 3
10 glucocorticoids Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
12 Antineoplastic Agents, Hormonal Phase 3
13 Hormone Antagonists Phase 3
14 Antiemetics Phase 3
15 Autonomic Agents Phase 3
16 BB 1101 Phase 3
17 Hormones Phase 3
18
protease inhibitors Phase 3
19 Anti-Inflammatory Agents Phase 3
20 HIV Protease Inhibitors Phase 3
21 Peripheral Nervous System Agents Phase 3
22 Pharmaceutical Solutions Phase 2
23 Ophthalmic Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Zylet vs Lotemax, Tobramycin and Vehicle in Pediatric Blepharoconjunctivitis Completed NCT00705159 Phase 4 loteprednol etabonate and tobramycin;loteprednol etabonate;Tobramycin;Vehicle of Zylet
2 Comparative Study of AzaSite Plus Compared to AzaSite Alone and Dexamethasone Alone to Treat Subjects With Blepharoconjunctivitis Completed NCT00578955 Phase 3 1% Azithromycin and 0.1% Dexamethasone;1% Azithromycin;0.1% Dexamethasone
3 Comparative Study of AzaSite Plus Compared to AzaSite Alone and Dexamethasone Alone to Treat Subjects With Blepharoconjunctivitis Withdrawn NCT00754949 Phase 3 1% Azithromycin and 0.1% Dexamethasone;1% Azithromycin;0.1% Dexamethasone
4 A Four Week, Open-Label Study of Azithromycin Ophthalmic Solution, 1% (P08641) Terminated NCT01220258 Phase 2 Azithromycin ophthalmic solution, 1%

Search NIH Clinical Center for Blepharoconjunctivitis

Genetic Tests for Blepharoconjunctivitis

Anatomical Context for Blepharoconjunctivitis

MalaCards organs/tissues related to Blepharoconjunctivitis:

42
Eye, T Cells, Testes, Lymph Node, Breast

Publications for Blepharoconjunctivitis

Articles related to Blepharoconjunctivitis:

(show top 50) (show all 96)
# Title Authors Year
1
<i>Phthirus pubis</i> Infestation of the Eyelids Presenting as Chronic Blepharoconjunctivitis in a 6-Year-Old Girl: A Case Report. ( 29643778 )
2018
2
Cicatrizing Blepharoconjunctivitis Occurring During Dupilumab Treatment and a Proposed Algorithm for Its Management. ( 30347029 )
2018
3
Effectiveness of 0.1% topical salicylic acid on blepharoconjunctivitis affecting glaucoma patients treated with topical prostaglandin analogues: a prospective randomized trial. ( 30588426 )
2018
4
Management of Neonatal Herpes Simplex Infection: A Rare Case of Blepharoconjunctivitis and Concurrent Epithelial and Stromal Keratitis. ( 27849421 )
2016
5
Blepharoconjunctivitis and an unusual location of metastatic breast carcinoma. ( 25547423 )
2015
6
Rosacea Blepharoconjunctivitis Treated with a Novel Preparation of Dilute Povidone Iodine and Dimethylsulfoxide: a Case Report and Review of the Literature. ( 26525679 )
2015
7
Bilateral blepharoconjunctivitis as the presenting sign of disseminated herpes simplex 1 infection in a preterm neonate. ( 24784884 )
2014
8
Beneficial IFN-I+ treatment of tumorous herpes simplex blepharoconjunctivitis in dedicator of cytokinesis 8 deficiency. ( 24698314 )
2014
9
Allergic blepharoconjunctivitis caused by acrylates promotes allergic rhinitis response. ( 25155084 )
2014
10
Long-term safety of topical pimecrolimus and topical tacrolimus in atopic blepharoconjunctivitis. ( 24500107 )
2014
11
Phthiriasis palpebrarum misdiagnosed as allergic blepharoconjunctivitis in a 6-year-old girl. ( 24909484 )
2014
12
A rare cause of blepharoconjunctivitis: Phthiriasis palpebrarum. ( 25385926 )
2014
13
Allergic contact dermatitis presenting as severe and persistent blepharoconjunctivitis and centrofacial oedema after dyeing of eyelashes. ( 25345792 )
2014
14
A Phase III clinical study to evaluate the efficacy of combined azithromycin and dexamethasone in the treatment of blepharoconjunctivitis. ( 24250221 )
2013
15
Oral acyclovir for herpes simplex blepharoconjunctivitis in children. ( 23732061 )
2013
16
Contact blepharoconjunctivitis due to black henna--a case report. ( 22492286 )
2012
17
Treatment of refractory atopic blepharoconjunctivitis with topical tacrolimus 0.03% dermatologic ointment. ( 22103968 )
2012
18
Evaluation of clinical efficacy and safety of tobramycin/dexamethasone ophthalmic suspension 0.3%/0.05% compared to azithromycin ophthalmic solution 1% in the treatment of moderate to severe acute blepharitis/blepharoconjunctivitis. ( 21138337 )
2011
19
Tacrolimus ointment in atopic blepharoconjunctivitis does not seem to elevate intraocular pressure. ( 20064110 )
2011
20
Ocular demodicosis as a potential cause of pediatric blepharoconjunctivitis. ( 20847679 )
2010
21
Severe allergic blepharoconjunctivitis after eyelash colouring. ( 19300467 )
2010
22
Long-lasting allergic contact blepharoconjunctivitis to phenylephrine eyedrops. ( 19254293 )
2009
23
Sinonasal lymphoma masquerading as persistent blepharoconjunctivitis. ( 19229743 )
2009
24
A prospective study determining the efficacy of topical 0.5% levofloxacin on bacterial flora of patients with chronic blepharoconjunctivitis. ( 19205719 )
2009
25
Elevated expression and activation of matrix metalloproteinase 8 in tear fluid in atopic blepharoconjunctivitis. ( 18362656 )
2008
26
Necrotizing pseudomonas blepharoconjunctivitis. ( 17510872 )
2007
27
Effect of 0.03% tacrolimus ointment on conjunctival cytology in patients with severe atopic blepharoconjunctivitis: a retrospective study. ( 16965503 )
2006
28
Genetic background determines susceptibility to experimental immune-mediated blepharoconjunctivitis: comparison of Balb/c and C57BL/6 mice. ( 16102751 )
2006
29
Severe blepharoconjunctivitis induced by a peeling mask containing trichloroacetic acid. ( 16019688 )
2005
30
Discoid lupus erythematosus masquerading as chronic blepharoconjunctivitis. ( 15878050 )
2005
31
Dissection of antigen-specific humoral and cellular immune responses for the development of experimental immune-mediated blepharoconjunctivitis in C57BL/6 mice. ( 15823916 )
2005
32
Suppression of macrophage infiltration into the conjunctiva by clodronate liposomes in experimental immune-mediated blepharoconjunctivitis. ( 15893479 )
2005
33
Analysis of Ag-presenting cells in the conjunctiva during the development of experimental immune-mediated blepharoconjunctivitis. ( 15590473 )
2004
34
Artificial tears inhibit the development of experimental immune-mediated blepharoconjunctivitis. ( 15592776 )
2004
35
Group IIA phospholipase A2 content of tears in patients with atopic blepharoconjunctivitis. ( 15592866 )
2004
36
Phenotypic changes and inflammatory cell distribution in the cornea during development of experimental immune-mediated blepharoconjunctivitis. ( 15295657 )
2004
37
Detection of antigen-specific T cells in experimental immune-mediated blepharoconjunctivitis in DO11.10 T cell receptor transgenic mice. ( 14734856 )
2004
38
Ocular involvement in cutaneous leishmaniasis four cases with blepharoconjunctivitis. ( 15117121 )
2004
39
Mast-cell activation augments the late phase reaction in experimental immune-mediated blepharoconjunctivitis. ( 12682842 )
2003
40
Ag-specific recognition, activation, and effector function of T cells in the conjunctiva with experimental immune-mediated blepharoconjunctivitis. ( 14507881 )
2003
41
Severe allergic blepharoconjunctivitis induced by a dye for eyelashes and eyebrows. ( 14533035 )
2003
42
Phthiriasis palpebrarum: an unusual blepharoconjunctivitis. ( 12523816 )
2002
43
Suppression of experimental immune-mediated blepharoconjunctivitis in Brown Norway rats by topical application of FK506. ( 11931080 )
2002
44
Exertion of the suppressive effects of IFN-gamma on experimental immune mediated blepharoconjunctivitis in Brown Norway rats during the induction phase but not the effector phase. ( 12234900 )
2002
45
Allergic contact blepharoconjunctivitis from dorzolamide. ( 11683843 )
2001
46
Effects of IL-4 and IL-12 on experimental immune-mediated blepharoconjunctivitis in Brown Norway rats. ( 11012614 )
2000
47
Epitheliotropic lymphoma (mycosis fungoides) presenting as blepharoconjunctivitis in an Irish setter. ( 10976628 )
2000
48
Experimental immune-mediated blepharoconjunctivitis in rats induced by immunization with ragweed pollen. ( 10853935 )
2000
49
Allergic contact blepharoconjunctivitis due to phenylephrine eye drops. ( 10212859 )
1999
50
Inhibitory effects of FK506 on the development of experimental allergic/immune-mediated blepharoconjunctivitis in Lewis rats by systemic but not by topical administration. ( 10333108 )
1999

Variations for Blepharoconjunctivitis

Expression for Blepharoconjunctivitis

Search GEO for disease gene expression data for Blepharoconjunctivitis.

Pathways for Blepharoconjunctivitis

Pathways related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.43 CCL11 IL4
2
Show member pathways
11.32 CMA1 MMP8
3 11.11 CCL11 IL4
4 10.96 CCL11 IL4
5 10.62 CCL11 IL4
6 10.6 CCL11 CMA1 IL4

GO Terms for Blepharoconjunctivitis

Cellular components related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CCL11 CMA1 IL4 MMP8 RNASE3
2 extracellular space GO:0005615 9.02 CCL11 CMA1 IL4 MMP8 RNASE3

Biological processes related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to glucose stimulus GO:0071333 8.96 CMA1 GJB6
2 extracellular matrix disassembly GO:0022617 8.62 CMA1 MMP8

Molecular functions related to Blepharoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 CMA1 MMP8

Sources for Blepharoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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