MCID: BLN006
MIFTS: 39

Blind Loop Syndrome

Categories: Gastrointestinal diseases

Aliases & Classifications for Blind Loop Syndrome

MalaCards integrated aliases for Blind Loop Syndrome:

Name: Blind Loop Syndrome 12 44 15 73
Bacterial Overgrowth Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10606
ICD10 33 K90.2
ICD9CM 35 579.2
MeSH 44 D001765
NCIt 50 C34431
SNOMED-CT 68 66379009 77225009
UMLS 73 C0005750

Summaries for Blind Loop Syndrome

Disease Ontology : 12 An intestinal disease characterized by a dysbalance of the bacterial flora of the small intestine, causing derangement to the normal physiological processes of digestion and absorption.

MalaCards based summary : Blind Loop Syndrome, also known as bacterial overgrowth syndrome, is related to protein-losing enteropathy and duodenal atresia. An important gene associated with Blind Loop Syndrome is HBD (Hemoglobin Subunit Delta), and among its related pathways/superpathways is Secretion of Hydrochloric Acid in Parietal Cells. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and skin, and related phenotypes are Decreased viability with TRAIL and Reduced mammosphere formation

Wikipedia : 76 Blind loop syndrome (BLS) is a state that occurs when the normal bacterial flora of the small intestine... more...

Related Diseases for Blind Loop Syndrome

Diseases related to Blind Loop Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 protein-losing enteropathy 29.5 ALB SERPINA1
2 duodenal atresia 11.1
3 fungal esophagitis 10.3 ATP12A ATP4A
4 diclofenac allergy 10.3 ATP12A ATP4A
5 neonatal candidiasis 10.3 ATP12A ATP4A
6 photoallergic dermatitis 10.3 ATP12A ATP4A
7 squamous papillomatosis 10.3 ATP12A ATP4A
8 toxic megacolon 10.3 ATP12A ATP4A
9 gastric antral vascular ectasia 10.3 ATP12A ATP4A
10 esophageal candidiasis 10.3 ATP12A ATP4A
11 acute laryngitis 10.3 ATP12A ATP4A
12 hemoglobin lepore-beta-thalassemia syndrome 10.3 HBD HBB
13 duodenitis 10.3 ATP12A ATP4A
14 rumination disorder 10.3 ATP12A ATP4A
15 hemoglobin d disease 10.3 HBD HBB
16 congenital disorder of deglycosylation 10.3 ATP12A ATP4A
17 bladder calculus 10.3 ATP12A ATP4A
18 ischemic neuropathy 10.3 ATP12A ATP4A
19 bile reflux 10.3 ATP12A ATP4A
20 dyskinesia of esophagus 10.3 ATP12A ATP4A
21 malignant secondary hypertension 10.3 HBB HBD
22 hernia, hiatus 10.3 ATP12A ATP4A
23 anismus 10.3 ATP12A ATP4A
24 hemoglobin c disease 10.3 HBB HBD
25 hemoglobin e disease 10.3 HBB HBD
26 osgood-schlatter's disease 10.3 HBB HBD
27 postsurgical hypothyroidism 10.3 ATP12A ATP4A
28 lymphocytic colitis 10.3 ATP12A ATP4A
29 esophageal atresia/tracheoesophageal fistula 10.3 ATP12A ATP4A
30 clostridium difficile colitis 10.3 ATP12A ATP4A
31 fetal hemoglobin quantitative trait locus 1 10.3 HBB HBD
32 diarrhea 1, secretory chloride, congenital 10.3 ATP12A ATP4A
33 microscopic colitis 10.2 ATP12A ATP4A
34 kluver-bucy syndrome 10.2 HBB HBD
35 laryngeal tuberculosis 10.2 ATP12A ATP4A
36 drug allergy 10.2 ALB ATP12A
37 malignant essential hypertension 10.2 HBB HBD
38 gastritis, familial giant hypertrophic 10.2 ALB SERPINA1
39 paramyloidosis 10.2 TTR ALB
40 eosinophilic gastritis 10.2 ATP12A ATP4A
41 constrictive pericarditis 10.2 ALB SERPINA1
42 aspiration pneumonitis 10.2 HRH2 ATP4A ATP12A
43 active peptic ulcer disease 10.2 HRH2 ATP4A ATP12A
44 peptic esophagitis 10.2 HRH2 ATP4A ATP12A
45 laryngitis 10.2 HRH2 ATP4A ATP12A
46 chronic laryngitis 10.2 HRH2 ATP4A ATP12A
47 esophagus adenocarcinoma 10.2 ATP12A ATP4A
48 hepatic tuberculosis 10.2 ALB SERPINA1
49 chronic intestinal vascular insufficiency 10.2 ATP12A ATP4A
50 capillary disease 10.2 ATP4A ATP12A ALB

Comorbidity relations with Blind Loop Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Blind Loop Syndrome:



Diseases related to Blind Loop Syndrome

Symptoms & Phenotypes for Blind Loop Syndrome

GenomeRNAi Phenotypes related to Blind Loop Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with TRAIL GR00240-S-2 9.13 HBD MLN TTR
2 Reduced mammosphere formation GR00396-S 9.1 ALB ATP4A GHRL HTR4 RPS3A TTR

MGI Mouse Phenotypes related to Blind Loop Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 ALB ATP12A ATP4A GHRL HRH2 TNFAIP3

Drugs & Therapeutics for Blind Loop Syndrome

Drugs for Blind Loop Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Not Applicable 50-78-2 2244
2
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
3
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
4
Pravastatin Approved Phase 4 81093-37-0 54687
5 Peripheral Nervous System Agents Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Anti-Inflammatory Agents, Non-Steroidal Phase 4
8 Antirheumatic Agents Phase 4
9 Platelet Aggregation Inhibitors Phase 4
10 Analgesics Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Anti-Inflammatory Agents Phase 4,Not Applicable
13 Antipyretics Phase 4
14 Fibrinolytic Agents Phase 4
15 Calcium, Dietary Phase 4,Early Phase 1
16 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
17 Atorvastatin Calcium Phase 4 134523-03-8
18 Chinese Salvia Phase 4,Not Applicable
19 Anticholesteremic Agents Phase 4
20 Lipid Regulating Agents Phase 4
21 Antimetabolites Phase 4
22 Hypolipidemic Agents Phase 4
23
Silver sulfadiazine Approved, Vet_approved Phase 2 22199-08-2 441244
24
Sulfadiazine Approved, Investigational, Vet_approved Phase 2 68-35-9 5215
25
Ginseng Approved, Investigational, Nutraceutical Phase 2,Not Applicable 50647-08-0
26 Pharmaceutical Solutions Phase 2
27
Neomycin Approved, Vet_approved Not Applicable 1404-04-2 8378
28
Erythromycin Approved, Investigational, Vet_approved Not Applicable 114-07-8 12560
29 Tangerine Approved Not Applicable
30
Calcitriol Approved, Nutraceutical Early Phase 1 32222-06-3 5280453 134070
31 Liver Extracts Not Applicable
32 Anti-Infective Agents Not Applicable
33 Erythromycin stearate Not Applicable
34 Anti-Bacterial Agents Not Applicable
35 Gastrointestinal Agents Not Applicable
36 Erythromycin Estolate Not Applicable
37 Erythromycin Ethylsuccinate Not Applicable
38 Antibiotics, Antitubercular
39 Astragalus Not Applicable
40 Dong Quai Not Applicable
41 Angelica Not Applicable
42 Vasoconstrictor Agents Early Phase 1
43 Vitamins Early Phase 1
44 Trace Elements Early Phase 1
45 Micronutrients Early Phase 1
46 Bone Density Conservation Agents Early Phase 1

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 The Effect of Tongguan Capsule for MicroRNA Profiles in Coronary Heart Disease Patients Unknown status NCT02850627 Phase 4 Tongguan capsule;placebo capsule
2 Effectiveness and Safety of Yiqitongluo Granule for Stroke Unknown status NCT02604654 Phase 4 Yiqitongluo granule
3 Clinical Study of Combination Therapy for Angina of Coronary Heart Disease With Aspirin and Salvianolate Injection Unknown status NCT02694848 Phase 4 Salvianolate injection;Aspirin
4 Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke Completed NCT01762163 Phase 4 Qizhitongluo Capsule;Naoxintong Capsule;Aspirin Enteric-coated Tablets;placebo
5 Studies of Traditional Chinese Medicine Clinical Efficacy Evaluation Index Completed NCT01502943 Phase 4 Louxiangdan Tongxin granules;TCM granules placebo;Chixiangshen Tongxin granules;TCM granule placebo plus western basis treatment;Western basis treatment
6 Danhong Injection in the Treatment of Acute Ischemic Stroke Recruiting NCT01677208 Phase 4 Danhong injection;placebo
7 The Study of MicroRNA Genomics of Blood Stasis Syndrome and of Coronary Heart Disease Unknown status NCT01615003 Phase 2 Xuesaitong soft capsule;Xuesaitong soft capsule Placebo
8 Multicentre, Randomized, Controlled Trial of Qideng Mingmu Capsule in The Treatment of Diabetic Retinopathy Completed NCT01373476 Phase 2 Qideng Mingmu capsule;Placebo Comparator
9 Observing the Curative Effect of Assisted Reproduction by TCM Multi-channel Interventional Therapy Completed NCT02303665 Phase 2
10 The Efficacy and Safety of the Xue-Fu-Zhu-Yu Capsule in Treatment of Qi Stagnation and Blood Stasis Syndrome. Recruiting NCT03091634 Phase 2 xue-fu-zhu-yu capsule;xue-fu-zhu-yu capsule simulated agent
11 Efficacy and Safety of Xuesaitong Soft Capsule for Coronary Heart Disease Unstable Angina Recruiting NCT03083119 Phase 2 Xuesaitong soft capsule;Placebo oral capsule
12 A Clinical Research of Qi Deficiency and Blood Stasis Syndrome (Different Disease With Syndrome) Recruiting NCT02875639 Phase 2 Yiqi prescription;Huoxue prescription;Buyang huanwu decoction;QISHEN YIQI DRIPPING PILLS;Placebo 1;Placebo 2
13 Observation on the Curative Effect of Assisted Reproduction by TCM Multi-channel Interventional Therapy Recruiting NCT03078205 Phase 2
14 Uncut Roux-en-Y Gastrojejunostomy for Early Gastric Cancer Patients Recruiting NCT02644148 Phase 2
15 Clinical Evaluation and Generalized Application of "Qing-Hua-Bu" Three Dynamic Sequential Therapy of Diabetic Ulcer Not yet recruiting NCT03574935 Phase 2 External Chinese medicine;External Western medicine
16 Innovation Research of Differentiation and Treatment Methods Based on CHD Phlegm and Blood Stasis Syndrome Unknown status NCT02967718
17 Clinical Study On The Relation Among Prescription, Syndrome and Disease of Turbid Phlegm and Blood Stasis for Coronary Heart Disease Unknown status NCT02526381 Not Applicable Danlou Tablets;Tongmai Yangxin Pills
18 Comparison Between Erythromycin and Neomycin Treatment of Hepatic Encephalopathy Unknown status NCT01097811 Not Applicable Erythromycin;Neomycin
19 Retrospective Analysis of Treatment Outcomes in Patients With Bacterial Overgrowth Syndrome Diagnosed by D-Xylose Breath Testing Completed NCT01324895
20 Dynamic Combination Therapy on Chinese Herbal Granules to Improve the Symptoms in Convalescent Phase of Ischemic Stroke Completed NCT01780480 Not Applicable Dynamic Chinese herbal granule formula;Placebo
21 Pilot Study for VeinoPlus to Improve Symptoms of Postthrombotic Syndrome (PTS) Completed NCT00858130 Not Applicable
22 Clinical Application and Basic Study of Medicinal Fractions-based Herbal Combinations Completed NCT01636154 Not Applicable Ixeris of sonchifolia Hance;Panax notoginseng saponins;Ixeris of sonchifolia Hance combined with Panax notoginseng saponins
23 Screening Protein Markers in Patients With Rheumatoid Arthritis and Hot-dampness and Blood Stasis Syndrome Recruiting NCT02408094
24 Small Intestinal Bacterial Overgrowth Obese Recruiting NCT02819037 Not Applicable
25 Uncut Roux-en-Y vs Roux-en-Y Recruiting NCT03349398 Not Applicable
26 Yiqi Huoxue Demolition and Recipes on Recovery Stage of Cerebral Infarction Recruiting NCT02846207 Not Applicable Yiqi huoxue;Yiqi group;Huoxue group;placebo
27 Heat-clearing and Blood-activating Chinese Medicinal Components in Acute Cerebral Infarction Recruiting NCT02544087 Not Applicable Ixeris of sonchifolia Hance;Panax notoginseng saponins;Ixeris of sonchifolia Hance combined with Panax notoginseng saponins
28 Impact of Traditional Chinese Medicine on the Gut Microbiota-dependent Trimethylamine N-oxide Recruiting NCT03186625 Not Applicable Compound Panax Notoginseng Granule;Placebo Granule
29 Clinical Study on Treatment of Postmenopausal Osteoporosis (Kidney Deficiency and Blood Stasis Syndrome) With Xulin Jiangu Granules Not yet recruiting NCT03563235 Early Phase 1 Xulin Jiangu granules;Calcitriol capsules
30 Clinical Trial of PSORI-CM01(YXBCM01) Granule to Treat Stable Plaque Psoriasis Terminated NCT02153840 Not Applicable PSORI-CM01(YXBCM01) granule;placebo

Search NIH Clinical Center for Blind Loop Syndrome

Cochrane evidence based reviews: blind loop syndrome

Genetic Tests for Blind Loop Syndrome

Anatomical Context for Blind Loop Syndrome

MalaCards organs/tissues related to Blind Loop Syndrome:

41
Small Intestine, Testes, Skin, Colon, Thyroid

Publications for Blind Loop Syndrome

Articles related to Blind Loop Syndrome:

(show top 50) (show all 96)
# Title Authors Year
1
Small intestinal bacterial overgrowth syndrome in children. ( 25960812 )
2015
2
A Case of Blind Loop Syndrome Caused by Infection with Giardia duodenalis Diagnosed with Double Balloon Enteroscopy. ( 25408630 )
2014
3
Migrating motor complex changes after side-to-side ileal bypass in mouse ileum ex-vivo: mechanism underlying the blind loop syndrome? ( 22066044 )
2011
4
Reversible acute reactive arthritis secondary to iatrogenic blind loop syndrome. ( 17925936 )
2007
5
Prospective study of bacterial overgrowth syndrome in eight dogs. ( 16581994 )
2006
6
Absorbable vs. non-absorbable antibiotics in the treatment of small intestine bacterial overgrowth in patients with blind-loop syndrome. ( 15813834 )
2005
7
Leiomyosarcoma of the small intestine presenting with bacterial overgrowth syndrome. ( 11743261 )
2002
8
Enteric bacterial flora and bacterial overgrowth syndrome. ( 12462706 )
2002
9
Blind loop syndrome after biliopancreatic diversion: a diagnostic challenge. ( 11594112 )
2001
10
Small Intestinal Bacterial Overgrowth Syndrome. ( 11177677 )
2001
11
Rapid enantiomeric differentiation of urinary metabolites in a patient with bacterial overgrowth syndrome. ( 10973888 )
2000
12
Blind loop syndrome. Diagnosis by In-111-labeled leukocyte scintigraphy. ( 10439196 )
1999
13
Bacterial populations contaminating the upper gut in patients with small intestinal bacterial overgrowth syndrome. ( 10235214 )
1999
14
Blind loop syndrome: an unusual cause of panniculitis. ( 9366844 )
1997
15
The ursodeoxycholic acid-p-aminobenzoic acid deconjugation test, a new tool for the diagnosis of bacterial overgrowth syndrome. ( 9262976 )
1997
16
Blind loop syndrome: multiple ileal ulcers following side-to-side anastomosis. ( 8165008 )
1993
17
The blind loop syndrome in children. ( 2401946 )
1990
18
The deconjugation ability of bacteria isolated from the jejunal fluids in the blind loop syndrome with high 14CO2 excretion--using the breath analysis technique and thin-layer chromatography. ( 2513463 )
1989
19
Percutaneous duodenostomy in blind loop syndrome. ( 2451880 )
1988
20
Impaired intestinal sodium and chloride transport in the blind loop syndrome of the rat. ( 2434383 )
1987
21
Adaptation of the jejunal mucosa in the experimental blind loop syndrome: changes in paracellular conductance and tight junction structure. ( 3692303 )
1987
22
Ischemic jejunal stenosis and blind loop syndrome after blunt abdominal trauma. ( 3559122 )
1987
23
Small bowel bacterial overgrowth syndrome. ( 3311488 )
1987
24
Blind loop syndrome, vitamin E malabsorption, and spinocerebellar degeneration. ( 3974892 )
1985
25
Postgastrectomy blind loop syndrome and the arthritis-dermatitis syndrome. ( 3970735 )
1985
26
Choledochoduodenostomy and the blind loop syndrome. ( 4041721 )
1985
27
Short-chain fatty acids in the small-bowel bacterial overgrowth syndrome. ( 4023615 )
1985
28
Breath hydrogen test in infants and children with blind loop syndrome. ( 6737180 )
1984
29
Altered motility and duration of bacterial overgrowth in experimental blind loop syndrome. ( 6376005 )
1984
30
Blind loop syndrome and small bowel bacterial contamination. ( 6347463 )
1983
31
Altered myoelectric activity in the experimental blind loop syndrome. ( 6350361 )
1983
32
Small bowel bacterial overgrowth syndrome. ( 6353559 )
1983
33
Blind loop syndrome following iatrogenic intestinal bypass in a child. ( 7141516 )
1982
34
Gut damage in human blind-loop syndrome. ( 7239120 )
1981
35
Protein-losing enteropathy in the human and experimental rat blind-loop syndrome. ( 7450442 )
1981
36
Glycoprotein degradation in the blind loop syndrome: identification of glycosidases in jejunal contents. ( 6257760 )
1981
37
Importance of anaerobic bacteria in the cobalamin malabsorption of the experimental rat blind loop syndrome. ( 7450422 )
1981
38
Small intestinal bacterial overgrowth syndrome. ( 6781975 )
1981
39
Sensitivity of bile acid breath test in the diagnosis of bacterial overgrowth in the small intestine with and without the stagnant (blind) loop syndrome. ( 428288 )
1979
40
Osteomalacia complicating a blind loop syndrome from congenital megaesophagus-megaduodenum. ( 439112 )
1979
41
Protein digestion and absorption in the blind loop syndrome. ( 510093 )
1979
42
Pathogenesis of mucosal injury in the blind loop syndrome. ( 359400 )
1978
43
Enterotoxigenicity of colonising coliform bacteria in tropical sprue and blind-loop syndrome. ( 79710 )
1978
44
Xylose catabolism in the experimental rat blind loop syndrome: studies, including use of a newly developed d-[14C]xylose breath test. ( 631506 )
1978
45
Bacterial overgrowth syndrome without "blind loop". ( 74593 )
1978
46
Bacterial overgrowth syndrome after acute nonspecific diarrhoea. ( 75380 )
1978
47
Bacterial overgrowth syndrome without blind loop. ( 75381 )
1978
48
Diagnosis of blind-loop syndrome by X-ray/breath-hydrogen test. ( 64837 )
1977
49
Brush border peptidases and arylamidases in the experimental blind loop syndrome of the rat. ( 930537 )
1977
50
Pathogenesis of mucosal injury in the blind loop syndrome. Brush border enzyme activity and glycoprotein degradation. ( 410830 )
1977

Variations for Blind Loop Syndrome

Expression for Blind Loop Syndrome

Search GEO for disease gene expression data for Blind Loop Syndrome.

Pathways for Blind Loop Syndrome

Pathways related to Blind Loop Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.32 ATP4A HRH2

GO Terms for Blind Loop Syndrome

Cellular components related to Blind Loop Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ALB ATP4A CBLIF GHRL HBB SERPINA1
2 blood microparticle GO:0072562 9.43 ALB HBB HBD
3 hemoglobin complex GO:0005833 8.96 HBB HBD
4 haptoglobin-hemoglobin complex GO:0031838 8.62 HBB HBD

Biological processes related to Blind Loop Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrogen peroxide catabolic process GO:0042744 9.43 HBB HBD
2 cellular sodium ion homeostasis GO:0006883 9.4 ATP12A ATP4A
3 oxygen transport GO:0015671 9.37 HBB HBD
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP12A ATP4A
5 cellular potassium ion homeostasis GO:0030007 9.26 ATP12A ATP4A
6 sodium ion export across plasma membrane GO:0036376 9.16 ATP12A ATP4A
7 cellular oxidant detoxification GO:0098869 9.13 ALB HBB HBD
8 negative regulation of interleukin-1 beta production GO:0032691 8.62 GHRL TNFAIP3

Molecular functions related to Blind Loop Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.61 GHRL MLN TTR
2 oxygen carrier activity GO:0005344 9.4 HBB HBD
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.37 ATP12A ATP4A
4 organic acid binding GO:0043177 9.32 HBB HBD
5 haptoglobin binding GO:0031720 9.26 HBB HBD
6 hemoglobin alpha binding GO:0031721 9.16 HBB HBD
7 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A
8 oxygen binding GO:0019825 8.8 ALB HBB HBD

Sources for Blind Loop Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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