MCID: BLN006
MIFTS: 34

Blind Loop Syndrome

Categories: Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Blind Loop Syndrome

MalaCards integrated aliases for Blind Loop Syndrome:

Name: Blind Loop Syndrome 12 44 15 17 70
Bacterial Overgrowth Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10606
ICD9CM 34 579.2
MeSH 44 D001765
NCIt 50 C34431
SNOMED-CT 67 77225009
ICD10 32 K90.2
UMLS 70 C0005750

Summaries for Blind Loop Syndrome

Disease Ontology : 12 An intestinal disease characterized by a dysbalance of the bacterial flora of the small intestine, causing derangement to the normal physiological processes of digestion and absorption.

MalaCards based summary : Blind Loop Syndrome, also known as bacterial overgrowth syndrome, is related to duodenal obstruction and meckel diverticulum. An important gene associated with Blind Loop Syndrome is GIT2 (GIT ArfGAP 2). The drugs Rifaximin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related phenotype is liver/biliary system.

Wikipedia : 73 Blind loop syndrome (BLS), also known as stagnant loop syndrome, is a state that occurs when the normal... more...

Related Diseases for Blind Loop Syndrome

Diseases related to Blind Loop Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 duodenal obstruction 30.1 ATP4A ATP12A ALB
2 meckel diverticulum 30.0 ATP4A ALB
3 tropical sprue 29.8 CBLIF ATP4A ATP12A ALB
4 intestinal obstruction 29.7 MLN ATP4A ATP12A ALB
5 constipation 29.7 MLN ATP4A ATP12A ALB
6 volvulus of midgut 29.7 MLN ATP4A ATP12A ALB
7 perinatal necrotizing enterocolitis 29.5 FABP2 ALB
8 celiac disease 1 29.2 FABP2 ATP4A ATP12A ALB
9 duodenal atresia 11.2
10 overgrowth syndrome 10.5
11 vagus nerve disease 10.3 ATP4A ATP12A
12 necrotizing gastritis 10.3 ATP4A ATP12A
13 scalp dermatosis 10.3 ATP4A ATP12A
14 hemangioma of intra-abdominal structure 10.3 ATP4A ATP12A
15 acquired gastric outlet stenosis 10.3 ATP4A ATP12A
16 lingual goiter 10.3 ATP4A ATP12A
17 displacement of cardia through esophageal hiatus 10.3 ATP4A ATP12A
18 bacterial esophagitis 10.3 ATP4A ATP12A
19 cascade stomach 10.3 ATP4A ATP12A
20 benzylpenicillin allergy 10.3 ATP4A ATP12A
21 median arcuate ligament syndrome 10.3 ATP4A ATP12A
22 cervix erosion 10.3 ATP4A ATP12A
23 angiodysplasia of intestine 10.3 ATP4A ATP12A
24 angiodysplasia 10.3 ATP4A ATP12A
25 granulomatous gastritis 10.3 ATP4A ATP12A
26 laryngeal tuberculosis 10.3 ATP4A ATP12A
27 fungal esophagitis 10.3 ATP4A ATP12A
28 dieulafoy lesion 10.3 ATP4A ATP12A
29 esophagus melanoma 10.3 ATP4A ATP12A
30 cefuroxime allergy 10.3 ATP4A ATP12A
31 emphysematous cholecystitis 10.3 ATP4A ATP12A
32 gastric gastrinoma 10.3 ATP4A ATP12A
33 superior mesenteric artery syndrome 10.3 ATP4A ATP12A
34 chronic laryngitis 10.3 ATP4A ATP12A
35 laryngitis 10.3 ATP4A ATP12A
36 viral laryngitis 10.3 ATP4A ATP12A
37 gastroduodenal crohn's disease 10.3 ATP4A ATP12A
38 central nervous system origin vertigo 10.3 ATP4A ATP12A
39 internal hemorrhoid 10.3 ATP4A ATP12A
40 acute laryngitis 10.3 ATP4A ATP12A
41 gastroduodenitis 10.3 ATP4A ATP12A
42 barbiturate abuse 10.3 ATP4A ATP12A
43 duodenal gastrinoma 10.3 ATP4A ATP12A
44 gastric dilatation 10.2 ATP4A ATP12A
45 gastric hemangioma 10.2 ATP4A ATP12A
46 polycystic echinococcosis 10.2 ATP4A ATP12A
47 lymphocytic gastritis 10.2 ATP4A ATP12A
48 x-linked chondrodysplasia punctata 1 10.2 ATP4A ATP12A
49 pancreatic gastrinoma 10.2 ATP4A ATP12A
50 epidermolysis bullosa simplex, ogna type 10.2 ATP4A ATP12A

Comorbidity relations with Blind Loop Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Blind Loop Syndrome:



Diseases related to Blind Loop Syndrome

Symptoms & Phenotypes for Blind Loop Syndrome

MGI Mouse Phenotypes related to Blind Loop Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.02 ALB CBLIF FABP2 LBP OTC

Drugs & Therapeutics for Blind Loop Syndrome

Drugs for Blind Loop Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifaximin Approved, Investigational Phase 2, Phase 3 80621-81-4 6436173 46783403
2 Anti-Bacterial Agents Phase 2, Phase 3
3 Anti-Infective Agents Phase 2, Phase 3
4 Gastrointestinal Agents Phase 2, Phase 3
5 Liver Extracts Phase 2, Phase 3
6
Ethanol Approved 64-17-5 702
7
Calcitriol Approved, Nutraceutical Early Phase 1 32222-06-3 5280453 134070
8 Antibiotics, Antitubercular
9 Ginkgo
10 Vasoconstrictor Agents Early Phase 1
11 Nutrients Early Phase 1
12 Trace Elements Early Phase 1
13 Micronutrients Early Phase 1
14 Vitamins Early Phase 1
15 Hormones Early Phase 1
16 Calcium, Dietary Early Phase 1
17
Calcium Nutraceutical Early Phase 1 7440-70-2 271

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 To Evaluate the Efficacy and Safety of Xinnaoning Capsule in Treating Chronic Stable Angina Pectoris (Qi Stagnation and Blood Stasis Syndrome) : a Randomized, Double-blind, Parallel Controlled, Multi-center Clinical Study Unknown status NCT03914131 Phase 4 Xinnaoning Capsule
2 The Efficacy and Safety of Xuefu Zhuyu Capsule in Treating "Qizhi Xueyu Zheng" (Qi Stagnation and Blood Stasis Syndrome): a Randomized, Double-blind, Placebo-controlled, Adaptive Enrichment, Multicenter Controlled Trial Recruiting NCT04218487 Phase 4 Xuefu-Zhuyu Capsule;placebo
3 Primary Prophylaxis for Spontaneous Bacterial Peritonitis in Decompensated Chronic Liver Disease With Small Bowel Bacterial Overgrowth: A Randomised Trial Recruiting NCT04775329 Phase 2, Phase 3 Rifaximin
4 The Analysis of Blood Stasis Syndromeand of Coronary Heart Disease Related MicroRNA Genomics and Target Gene Regulatory Networks Unknown status NCT01615003 Phase 2 Xuesaitong soft capsule;Xuesaitong soft capsule Placebo
5 The Efficacy and Safety of the Xue-Fu-Zhu-Yu Capsule in Treating qi Stagnation and Blood Stasis Syndrome: a Multicenter, Double-blind, Randomized and Placebo-controlled Trial Completed NCT03091634 Phase 2 xue-fu-zhu-yu capsule;xue-fu-zhu-yu capsule simulated agent
6 Buqitongluo Granule for Qi Deficiency and Blood Stasis Syndrome: A Multicenter, Randomized, Double-blind, Placebo-Controlled Trial Recruiting NCT04408261 Phase 2 Buqitongluo Granule;Buqitongluo Granule Placebo
7 Oral Chinese Herbal Medicine for Psoriasis Vulgaris With Blood Stasis Syndrome: a Randomised, Double-blind, Doubledummy, Multicentre Clinical Trial Not yet recruiting NCT03942198 Phase 2 Taodan Granules;Taodan Granules Placebo
8 Clinical Observation of CHD Phlegm and Blood-stasis Syndrome Patients Unknown status NCT02967718
9 Screening Sensitive Protein Markers and Exploring Application in Syndrome Diagnosis of Hot-dampness and Blood Stasis Syndrome in Patients With Rheumatoid Arthritis Unknown status NCT02408094
10 Retrospective Analysis of Treatment Outcomes in Patients With Bacterial Overgrowth Syndrome Diagnosed by D-Xylose Breath Testing Completed NCT01324895
11 Optimal Intensity and Frequency of a Portable Electrical Muscle Stimulator (VeinoPlus) to Improve Symptoms of Postthrombotic Syndrome Completed NCT00858130
12 Open-Label Assessment of the Efficacy of Atrantil In the Treatment of Methane-Predominate Intestinal Bacterial Overgrowth Recruiting NCT04755673
13 Modification of Digestive Flora After Gastric Bypass : Pilot Study on Microbial Overgrowth Using Gas Chromatography Recruiting NCT02819037
14 Effect of Ginkgo Biloba Capsule on Visual Function of Primary Open-angle Glaucoma With Blood Stasis Syndrome: a Randomized, Double-blind, Placebo Parallel Control, Multicenter Clinical Trial Recruiting NCT04334564 Ginkgo biloba capsule;Placebos
15 Clinical Utility of Handheld Hydrogen Breathalyzer in Identification of Non-immune Mediated Food Sensitivities (AIRE Study) Recruiting NCT04309396
16 Clinical Study on Treatment of Postmenopausal Osteoporosis (Kidney Deficiency and Blood Stasis Syndrome) With Xulin Jiangu Granules Not yet recruiting NCT03563235 Early Phase 1 Xulin Jiangu granules;Calcitriol capsules
17 Fire Needle Therapy on Plaque Psoriasis With Blood Stasis Syndrome: A Randomized, Single-blind, Multicentre Clinical Trial Not yet recruiting NCT03953885

Search NIH Clinical Center for Blind Loop Syndrome

Cochrane evidence based reviews: blind loop syndrome

Genetic Tests for Blind Loop Syndrome

Anatomical Context for Blind Loop Syndrome

MalaCards organs/tissues related to Blind Loop Syndrome:

40
Small Intestine, Liver, Colon

Publications for Blind Loop Syndrome

Articles related to Blind Loop Syndrome:

(show top 50) (show all 274)
# Title Authors PMID Year
1
[The role of intraepithelial lymphocytes in pathogenesis of small intestinal bacterial overgrowth syndrome]. 61
33713088 2021
2
Small Intestinal Bacterial Overgrowth Syndrome: A Guide for the Appropriate Use of Breath Testing. 61
33037967 2021
3
pn-Heterojunction of the SWCNT/ZnO nanocomposite for temperature dependent reaction with hydrogen. 61
33129166 2021
4
The importance of lactose intolerance in individuals with gastrointestinal symptoms. 61
32482516 2020
5
[Association of thermal food processing methods and small intestinal bacterial overgrowth syndrome]. 61
32790263 2020
6
Microbiota, Microbial Metabolites, and Barrier Function in A Patient with Anorexia Nervosa after Fecal Microbiota Transplantation. 61
31510101 2019
7
[Myocardial Contractile Function in Patients with Liver Cirrhosis and Syndrome of Bacterial Overgrowth Syndrome]. 61
31002042 2019
8
Therapeutic efficacy of amoxicillin and rifaximin in patients with small intestinal bacterial overgrowth and Helicobacter pylori infection. 61
30302165 2018
9
Ileo-ileal fistula with severe malnutrition caused by strangulated ileus surgery while preserving ischemic ileum: A case report. 61
29414503 2018
10
Colon adenocarcinoma after jejunoileal bypass for morbid obesity. 61
29230281 2017
11
Can psychobiotics intake modulate psychological profile and body composition of women affected by normal weight obese syndrome and obesity? A double blind randomized clinical trial. 61
28601084 2017
12
[The prevalence of bacterial overgrowth syndrome and its associated factors in patients with inflammatory bowel diseases (according to the data of the Novosibirsk registry)]. 61
28281510 2017
13
Use of an over-the-scope clipping device for closure of a jejuno-sigmoid fistula: a case report with long-term follow-up. 61
27664154 2016
14
Small Intestinal Bacterial Overgrowth Syndrome Prevalence in Romanian Patients with Inflammatory Bowel Disease. 61
30568826 2016
15
Small intestinal bacterial overgrowth syndrome in children. 61
25960812 2015
16
Irritable Bowel Syndrome and the Small Intestinal Microflora. What Do We Know? 61
26076568 2015
17
The treatment of gastroparesis, constipation and small intestinal bacterial overgrowth syndrome in patients with Parkinson's disease. 61
26374094 2015
18
[PEDIATRIC GASTROENTEROLOGY: ORIGINS, PROBLEMS, AND PROSPECTS OF THE RESEARCH]. 61
26281153 2015
19
A Case of Blind Loop Syndrome Caused by Infection with Giardia duodenalis Diagnosed with Double Balloon Enteroscopy. 61
25408630 2014
20
Blind loop perforation after side-to-side ileocolonic anastomosis. 61
25161764 2014
21
Maldigestion from pancreatic exocrine insufficiency. 61
24251713 2013
22
An efficient laboratory-scale preparative method for [1-(13)C]glycocholic acid. 61
24285191 2013
23
[Total colonic exclusion plus side to side ileorectal antiperistaltic anastomosis in the treatment for elderly patients with slow transit constipation]. 61
23888445 2013
24
Ultrasound of selected pathologies of the small intestine. 61
26672622 2013
25
Jejunoileal bypass as the main procedure in the onset of immune-related conditions: the model of BADAS. 61
23634738 2013
26
[The role of small bowel microflora in the development of secondary lactase deficiency and the possibilities of its treatment with probiotics]. 61
23653934 2013
27
Morphological and functional alterations of small intestine in chronic pancreatitis. 61
22964959 2012
28
Comparison of two shampoos as sole treatment for canine bacterial overgrowth syndrome. 61
22678617 2012
29
Difficulty in walking 10 years after gastric surgery. 61
21799420 2011
30
Migrating motor complex changes after side-to-side ileal bypass in mouse ileum ex-vivo: mechanism underlying the blind loop syndrome? 61
22066044 2011
31
[Diagnosis and treatment of the bacterial overgrowth syndrome in the small intestine]. 61
21695961 2011
32
[Efficacy of rifaximine in small intestinal bacterial overgrowth syndrome in patients after cholecystectomy]. 61
22416449 2011
33
Bacterial overgrowth syndrome in myotonic muscular dystrophy is potentially treatable. 61
21104859 2010
34
[Pulmonary hypertension--unusual complication of haemolysis and the bacterial overgrowth syndrome]. 61
20681463 2010
35
Small intestinal bacterial overgrowth syndrome. 61
20572300 2010
36
[Pulmonary hypertension--unusual complication of the bacterial overgrowth syndrome]. 61
20681459 2010
37
Bowel bacterial overgrowth as another cause of malnutrition, inflammation, and atherosclerosis syndrome in peritoneal dialysis patients. 61
21348395 2010
38
Complicated jejunal diverticulosis: A case report with literature review. 61
22666695 2009
39
[Small bowel diverticula - unknown disease]. 61
19606411 2009
40
Implementation and interpretation of hydrogen breath tests. 61
21386189 2008
41
Ileal stricture following strangulated inguinal hernia. 61
17988505 2007
42
Reversible acute reactive arthritis secondary to iatrogenic blind loop syndrome. 61
17925936 2007
43
Myelo-optico-neuropathy in copper deficiency occurring after partial gastrectomy. Do small bowel bacterial overgrowth syndrome and occult zinc ingestion tip the balance? 61
17415508 2007
44
Gut flora in health and small intestinal bacterial overgrowth syndrome. 61
18384008 2007
45
[Bacterial overgrowth syndrome]. 61
17620228 2007
46
Jejunal diverticular disease with unborn enterolith presenting as a small bowel obstruction: a case report. 61
17674945 2007
47
Gut flora in health and small intestinal bacterial overgrowth syndrome. 61
18050837 2007
48
[Postinfectious irritable bowel syndrome]. 61
17297754 2006
49
[Microecological aspects of small intestinal bacterial overgrowth syndrome]. 61
17163142 2006
50
Prospective study of bacterial overgrowth syndrome in eight dogs. 61
16581994 2006

Variations for Blind Loop Syndrome

Expression for Blind Loop Syndrome

Search GEO for disease gene expression data for Blind Loop Syndrome.

Pathways for Blind Loop Syndrome

GO Terms for Blind Loop Syndrome

Biological processes related to Blind Loop Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of G protein-coupled receptor signaling pathway GO:0008277 9.37 GIT2 GIT1
2 potassium ion import across plasma membrane GO:1990573 9.32 ATP4A ATP12A
3 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
5 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Blind Loop Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fatty acid binding GO:0005504 9.26 FABP2 ALB
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
3 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Blind Loop Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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