MCID: BLD051
MIFTS: 51

Blood Coagulation Disease

Categories: Blood diseases

Aliases & Classifications for Blood Coagulation Disease

MalaCards integrated aliases for Blood Coagulation Disease:

Name: Blood Coagulation Disease 12 15 17
Blood Coagulation Disorders 77 45 74
Postpartum Coagulation Defect with Delivery 12
Postpartum Coagulation Defect 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1247
ICD9CM 36 286
MeSH 45 D001778
NCIt 51 C2902
SNOMED-CT 69 64779008
ICD10 34 D68.9 O72.3
UMLS 74 C0005779

Summaries for Blood Coagulation Disease

MalaCards based summary : Blood Coagulation Disease, also known as blood coagulation disorders, is related to inherited blood coagulation disease and antithrombin iii deficiency. An important gene associated with Blood Coagulation Disease is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Warfarin and Tranexamic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and bone marrow, and related phenotypes are no effect and hematopoietic system

Wikipedia : 77 Coagulopathy (also called a bleeding disorder) is a condition in which the blood’s ability to coagulate... more...

Related Diseases for Blood Coagulation Disease

Diseases in the Blood Coagulation Disease family:

Inherited Blood Coagulation Disease

Diseases related to Blood Coagulation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 inherited blood coagulation disease 33.0 F2 F3 F7 F8 F9 GP1BA
2 antithrombin iii deficiency 32.0 F2 MTHFR SERPINC1
3 bleeding disorder, platelet-type, 16 32.0 ITGA2B ITGB3
4 pseudo-von willebrand disease 32.0 GP1BA GP9 VWF
5 acquired von willebrand syndrome 31.9 F8 F9 GP1BA VWF
6 prothrombin deficiency, congenital 31.9 F2 SERPINC1
7 factor vii deficiency 31.8 F2 F3 F7 F8 F9
8 hemophilia b 31.7 F2 F3 F7 F8 F9 SERPINC1
9 factor v deficiency 31.7 F2 F3 F7 F8 F9 VWF
10 bernard-soulier syndrome 31.2 F2 F8 GP1BA GP9 ITGA2B ITGB3
11 glanzmann thrombasthenia 31.1 F2 F3 F8 F9 GP1BA GP9
12 thrombosis 28.8 ADAMTS13 F2 F3 F7 F8 F9
13 gray platelet syndrome 10.9
14 bleeding disorder, platelet-type, 17 10.9
15 scott syndrome 10.9
16 quebec platelet disorder 10.9
17 bleeding disorder, platelet-type, 12 10.9
18 platelet glycoprotein iv deficiency 10.9
19 bleeding disorder, platelet-type, 8 10.9
20 bleeding disorder, platelet-type, 14 10.9
21 bleeding disorder, platelet-type, 9 10.9
22 bleeding disorder, platelet-type, 11 10.9
23 bleeding disorder, platelet-type, 15 10.9
24 bleeding disorder, platelet-type, 18 10.9
25 bleeding disorder, platelet-type, 19 10.9
26 bleeding disorder, platelet-type, 20 10.9
27 factor xiii deficiency 10.9
28 factor v and factor viii, combined deficiency of, 1 10.9
29 factor v and factor viii, combined deficiency of, 2 10.9
30 fainting 10.5 F8 VWF
31 unilateral absence of a pulmonary artery 10.5 THBD VWF
32 cerebral falx meningioma 10.5 F2 F3
33 intestinal impaction 10.5 F2 F3 SERPINC1
34 giant hemangioma 10.5 F2 F3 SERPINC1
35 sagittal sinus thrombosis 10.5 F2 F3 SERPINC1
36 hemorrhagic fever 10.5 F2 ITGB3 SERPINC1
37 blue toe syndrome 10.5 F2 F3 SERPINC1
38 bombay phenotype 10.5 ADAMTS13 VWF
39 cerebral arteritis 10.4 F8 VWF
40 heparin-induced thrombocytopenia 10.4 F3 SERPINC1
41 brachydactyly, type d 10.4 F2 F8 VWF
42 purpura fulminans 10.4 F2 F3 SERPINC1
43 factor viii deficiency 10.4 F2 F8 VWF
44 acquired hemophilia 10.4 F3 F8 F9
45 acquired hemophilia a 10.4 F3 F8 F9
46 peripheral vertigo 10.4 F2 F3 SERPINC1
47 prothrombin deficiency 10.4 F2 F3 F7
48 cerebral sinovenous thrombosis 10.4 F2 F3
49 hypersplenism 10.4 F2 SERPINC1 THPO
50 splenic disease 10.4 F2 F3 THPO

Graphical network of the top 20 diseases related to Blood Coagulation Disease:



Diseases related to Blood Coagulation Disease

Symptoms & Phenotypes for Blood Coagulation Disease

GenomeRNAi Phenotypes related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ADAMTS13 ATAT1 F2 F3 F7 F8

MGI Mouse Phenotypes related to Blood Coagulation Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.16 ADAMTS13 ATAT1 F2 F3 F8 F9
2 homeostasis/metabolism MP:0005376 10.09 ADAMTS13 F2 F3 F7 F8 F9
3 cardiovascular system MP:0005385 10.02 F2 F3 F7 F9 ITGA2B ITGB3
4 embryo MP:0005380 9.92 F2 F3 F9 ITGA2B ITGB3 MPL
5 immune system MP:0005387 9.73 ADAMTS13 F2 F3 F8 F9 ITGA2B
6 mortality/aging MP:0010768 9.47 ADAMTS13 ATAT1 F2 F3 F7 F8

Drugs & Therapeutics for Blood Coagulation Disease

Drugs for Blood Coagulation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1017)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 81-81-2 6691 54678486
2
Tranexamic Acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1197-18-8 5526
3
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 9005-49-6 772 46507594
4
Dalteparin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6
5
Nadroparin Approved, Investigational Phase 4,Not Applicable
6
Indomethacin Approved, Investigational Phase 4,Phase 3 53-86-1 3715
7
Resveratrol Approved, Experimental, Investigational Phase 4,Phase 2 501-36-0 445154
8
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 68-04-2
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-02-2 5743
10
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 1177-87-3
11
Melphalan Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 148-82-3 460612 4053
12
Bortezomib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 179324-69-7 387447 93860
13
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
14
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
15
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
16
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 23214-92-8 31703
17
Zoledronic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 118072-93-8 68740
18
Anti-inhibitor coagulant complex Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
19
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
20
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
21
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
22
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
23
Zinc Approved, Investigational Phase 4,Phase 2,Phase 1 7440-66-6 32051
24
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
25
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 104987-11-3 445643 439492 6473866
26
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2921-57-5
27
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
28
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
29
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
30
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302-25-0
31
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
32
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Phase 1 81103-11-9 84029
33
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
34
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 26787-78-0 33613
35
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
36
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
37
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable 446-86-6 2265
38
Hydroxychloroquine Approved Phase 4,Phase 1,Phase 2 118-42-3 3652
39
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
40
Lenalidomide Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 191732-72-6 216326
41
Enoxaparin Approved Phase 4,Phase 2,Phase 3,Not Applicable 9005-49-6 772
42
Sargramostim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 123774-72-1, 83869-56-1
43
Apixaban Approved Phase 4,Phase 3,Phase 2,Not Applicable 503612-47-3 10182969
44
Atorvastatin Approved Phase 4,Phase 2,Phase 1 134523-00-5 60823
45
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4, 65-46-3 6253
46
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
47
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 216974-75-3
48
Iron Approved, Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7439-89-6, 15438-31-0 23925 27284
49 Daratumumab Approved Phase 4,Phase 2,Phase 3,Phase 1 945721-28-8
50
Phylloquinone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84-80-0

Interventional clinical trials:

(show top 50) (show all 4294)
# Name Status NCT ID Phase Drugs
1 Trial of HoLEP vs. PVP in Treating BPH in Patients With Bleeding Tendency Unknown status NCT02293759 Phase 4
2 Clinical and Economic Implications of Genetic Testing for Warfarin Management Unknown status NCT00964353 Phase 4 Warfarin
3 The Effect of Human Albumin on Coagulation Competence and Hemorrhage Unknown status NCT02270723 Phase 4 5% Human Albumin " Behring";Lactated Ringer
4 Study Using Plasma for Patients Requiring Emergency Surgery Unknown status NCT01221389 Phase 4 Human Plasma
5 TXA in the EMS on the Helicopter and the Ambulance Unknown status NCT02354885 Phase 4 Tranexamic Acid
6 Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD Unknown status NCT01531829 Phase 4 Recombinant tissue plasminogen activator (rt-PA);Low Molecular Weight Heparin
7 Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography Unknown status NCT02757170 Phase 4
8 Prospective Validation of a Plasma Transfusion Dosing Algorithm in Patients With Chronic Liver Disease Unknown status NCT02366845 Phase 4
9 Oral Resveratrol to Prevent Post-ERCP Pancreatitis Unknown status NCT02947932 Phase 4 Resveratrol;Indomethacin
10 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Unknown status NCT02216305 Phase 4
11 Safety and Effectiveness of a Balanced 3rd Generation HES Solution (Tetraspan®) After Cardiac Surgery Unknown status NCT01418521 Phase 4 Balanced hydroxyethyl starch solution;Ringer- albumin
12 A Clinical Phenotype Based Individualized Prophylaxis in Chinese Hemophilia A Children Unknown status NCT02999308 Phase 4
13 Compare Efficacy and Simplicity of Regional Citrate Anticoagulation With Fixed Dose Versus Adjusted Citrate Program Unknown status NCT02663960 Phase 4
14 Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Unknown status NCT02314325 Phase 4 ADVATE [Antihemophilic Factor (Recombinant)];ADVATE [Antihemophilic Factor (Recombinant)]
15 Caffeic Acid Combining High-dose Dexamethasone in Management of ITP Unknown status NCT02556814 Phase 4 Caffeic acid tablets;Dexamethasone;placebo
16 Treatment With a Scheme With Low Doses of Bortezomib / Melphalan / Prednisone (MPV) in Patients With Multiple Myeloma Unknown status NCT02773550 Phase 4 Bortezomib;Melphalan;Prednisone
17 A Study of PAD Versus Velcade, Cyclophosphamide and Dexamethasone (VCD) Treatment in Subjects With Multiple Myeloma Unknown status NCT01868828 Phase 4 PAD;VCD
18 Efficacy Study of PAD and TAD in Newly Diagnosed Multiple Myeloma Unknown status NCT01249690 Phase 4 Bortezomib,Pirarubicin,Dexamethasone;Thalidomide,Pirarubicin,Dexamethasone
19 Stage I Multiple Myeloma Treatment Unknown status NCT00733538 Phase 4 zometa
20 Fibrinogen for Treatment of Pediatric Dilutional Coagulopathy. FibPaed Study. Completed NCT01487837 Phase 4 Human fibrinogen concentrate
21 The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders Completed NCT00904709 Phase 4 tranexamic acid
22 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
23 Comparison of Three Management Strategies for Post Cardiac Surgery Bleeding Completed NCT00188747 Phase 4
24 Conventional Versus Point-of-care Based Coagulation Management Completed NCT00997841 Phase 4
25 Anticoagulant Clinics and Vitamin K Antagonists Completed NCT00966290 Phase 4 Anticoagulant (warfarin, acenocoumarol, fluindione);Anticoagulant (warfarin, acenocoumarol, fluindione)
26 Effect of Colloid Versus Crystalloid on Coagulation in Elective Urological Surgery Completed NCT02009033 Phase 4 Lactated Ringer;Hydroxyethylstarch
27 Study of Safety and Efficacy of Antihemophilic Factor/Von Willebrand Factor Complex in Surgical Subjects With Von Willebrand Disease (vWD) Completed NCT00168090 Phase 4 Blood coagulation Factor VIII and vWF, human
28 Early Administration of Fibrinogen in Polytraumatized Patients With Hypofibrinogenemia: a Randomized Feasibility Trial Completed NCT02864875 Phase 4 Fibrinogen concentrate
29 BAY14-2222 Prophylaxis and Joint Function Improvement (Adults) Completed NCT00586521 Phase 4 Kogenate (BAY14-2222)
30 Safety and Efficacy of Activated Recombinant Human Factor VII in Haemophilia Patients With Inhibitors During and After Major Surgery Completed NCT01561391 Phase 4 activated recombinant human factor VII;activated recombinant human factor VII;factor VIII
31 Octaplas Pediatric Plasma Replacement Trial Completed NCT02050841 Phase 4
32 High Dose of Activated Recombinant Human Factor VII for Treatment of Mild/Moderate Joint Bleeds in Haemophilia Patients With Inhibitors Completed NCT00571584 Phase 4 activated recombinant human factor VII
33 Trial of NovoSeven® in Haemophilia - Joint Bleeds Completed NCT00108797 Phase 4 eptacog alfa (activated);Feiba VH
34 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy Completed NCT01269112 Phase 4
35 The Effect of Medication Timing on Anticoagulation Stability in Users of Warfarin: The "INRange" RCT Completed NCT02376803 Phase 4 Warfarin
36 Tranexamic Acid in Adolescents With Heavy Menstrual Bleeding Completed NCT01846507 Phase 4 Tranexamic Acid
37 Free Fatty Acid-Induced Hypertension in Obese Subjects With Type 2 Diabetes Completed NCT00738023 Phase 4 Rosiglitazone;Normal saline 0.9%;Intralipid 20%
38 International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage Completed NCT00928915 Phase 4 Prothrombin complex concentrate (PCC); fresh frozen plasma (FFP)
39 Effect of Low Dose Corticosteroids on Perioperative Markers of Thrombosis and Fibrinolysis in Total Knee Arthroplasty Completed NCT01815918 Phase 4 Hydrocortisone;Placebo
40 Antithrombotic Regimens and Outcome Completed NCT00448461 Phase 4 heparin;bivalirudin
41 Opioid-induced Hyperalgesia After Remifentanil Infusion Completed NCT01702389 Phase 4 Remifentanil
42 Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch Completed NCT01411891 Phase 4
43 Exploratory Phase II Study of INC424 Patients With Primary Myelofibrosis (PMF) or Post Polycythaemia Myelofibrosis (PPV MF) or Post Essential Thrombocythaemia Myelofibrosis (PET-MF) Completed NCT01558739 Phase 4 INC424
44 Survey of Inhibitors in Plasma-Product Exposed Toddlers Completed NCT01064284 Phase 4 PLASMA DERIVED Factor VIII;Recombinant FVIII
45 Phase 3/4 Study of a Recombinant Protein-Free Factor VIII (rAHF-PFM): Comparison of Continuous Infusion Versus Intermittent Bolus Infusion in Hemophilia A Subjects Undergoing Major Orthopedic Surgery Completed NCT00357656 Phase 4 Recombinant Protein-Free Factor VIII (rAHF-PFM);Recombinant Protein-Free Factor VIII (rAHF-PFM)
46 Dose-Response Study of Recombinant Factor VIII Manufactured Protein-Free (rAHF-PFM) in Patients With Hemophilia A Completed NCT00289536 Phase 4
47 IMMUNINE Pre-Treatment Study Completed NCT01128881 Phase 4
48 Early Whole Blood in Patients Requiring Transfusion After Major Trauma Completed NCT01227005 Phase 4
49 Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial Completed NCT01760967 Phase 4 Dexmedetomidine
50 Long-Term Effects of Insulin Plus Metformin Regimens on the Overall and Postprandial Glycemic Control of Patients With Type 2 Diabetes Completed NCT00191464 Phase 4 premeal insulin lispro mixtures;insulin glargine;metformin

Search NIH Clinical Center for Blood Coagulation Disease

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: blood coagulation disorders

Genetic Tests for Blood Coagulation Disease

Anatomical Context for Blood Coagulation Disease

MalaCards organs/tissues related to Blood Coagulation Disease:

42
Bone, T Cells, Bone Marrow, B Cells, Testes, Liver, Myeloid

Publications for Blood Coagulation Disease

Articles related to Blood Coagulation Disease:

(show all 13)
# Title Authors Year
1
A User-Friendly App for Blood Coagulation Disorders. ( 29380340 )
2018
2
Possibly propylthiouracil-induced antineutrophilic cytoplasmic antibody-associated vasculitis manifested as blood coagulation disorders: A case report. ( 27741122 )
2016
3
Blood coagulation disorders in septic patients. ( 20364416 )
2010
4
Hereditary blood coagulation disorders: management and dental treatment. ( 16246926 )
2005
5
Assessing quality of life in individuals with hereditary blood coagulation disorders. ( 15233512 )
2004
6
Blood coagulation disorders during primary cytomegalovirus infection. ( 11570949 )
2001
7
Drug induced blood coagulation disorders. ( 11507526 )
1999
8
[Blood coagulation disorders observed in arteriosclerosis obliterans]. ( 8808808 )
1996
9
Acute intrinsic renal failure and blood coagulation disorders after a snakebite in a dog. ( 7474966 )
1995
10
Cancer in persons with inherited blood coagulation disorders. ( 573172 )
1979
11
Studies on blood coagulation disorders in domestic animals. Thrombelastograms of normal cattle and cattle affected with bracken poisoning. ( 1241061 )
1975
12
An evaluation of the partial thromboplastin time in the detection of blood coagulation disorders. ( 5937814 )
1966
13
Studies on blood coagulation disorders in experimental leptospirosis. ( 13472979 )
1957

Variations for Blood Coagulation Disease

Expression for Blood Coagulation Disease

Search GEO for disease gene expression data for Blood Coagulation Disease.

Pathways for Blood Coagulation Disease

Pathways related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 F2 F3 F7 F8 F9 GP1BA
2
Show member pathways
12.74 F2 F3 F7 F8 F9 SERPINC1
3
Show member pathways
12.1 F2 ITGB3 PF4 THBD
4
Show member pathways
12.07 GP1BA GP9 ITGA2B ITGB3 VWF
5 12 F2 F3 F7 F8 F9 SERPINC1
6 11.92 GP1BA GP9 ITGA2B ITGB3 VWF
7 11.87 GP1BA ITGA2B ITGB3 MPL THPO
8
Show member pathways
11.78 F2 F7 F9
9 11.75 GP1BA GP9 ITGA2B ITGB3 THPO
10
Show member pathways
11.75 F2 GP1BA GP9 ITGA2B ITGB3 MPL
11 11.68 F3 ITGB3 VWF
12
Show member pathways
11.57 F2 F3 F7 F8 F9 GP1BA
13 11.43 F2 GP9 ITGA2B ITGB3 VWF
14 11.39 GP9 ITGA2B ITGB3
15 10.88 F2 F7 F9
16 10.8 GP1BA GP9 VWF
17 10.63 GP1BA GP9 VWF

GO Terms for Blood Coagulation Disease

Cellular components related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.71 F3 PF4 SERPINC1 VWF
2 cell surface GO:0009986 9.7 ADAMTS13 F3 GP1BA ITGA2B ITGB3 MPL
3 Golgi lumen GO:0005796 9.61 F2 F7 F9
4 platelet alpha granule lumen GO:0031093 9.54 F8 PF4 VWF
5 platelet alpha granule membrane GO:0031092 9.48 ITGA2B ITGB3
6 endoplasmic reticulum lumen GO:0005788 9.43 ADAMTS13 F2 F7 F8 F9 SERPINC1
7 extracellular space GO:0005615 9.36 ADAMTS13 F2 F3 F7 F8 F9
8 serine-type peptidase complex GO:1905286 9.26 F3 F7
9 plasma membrane GO:0005886 10.23 F2 F3 F7 F8 F9 GP1BA
10 extracellular region GO:0005576 10.02 ADAMTS13 F2 F3 F7 F8 F9

Biological processes related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 9.86 ADAMTS13 F2 F8 GP1BA GP9 ITGB3
2 ER to Golgi vesicle-mediated transport GO:0006888 9.81 F2 F7 F8 F9
3 cell-matrix adhesion GO:0007160 9.76 ADAMTS13 ITGA2B ITGB3
4 integrin-mediated signaling pathway GO:0007229 9.75 ADAMTS13 ITGA2B ITGB3
5 blood coagulation GO:0007596 9.73 ADAMTS13 F2 F3 F7 F8 F9
6 platelet degranulation GO:0002576 9.72 F8 ITGA2B ITGB3 PF4 VWF
7 regulation of megakaryocyte differentiation GO:0045652 9.7 GP1BA ITGA2B PF4
8 protein processing GO:0016485 9.67 ADAMTS13 F3 F7
9 platelet aggregation GO:0070527 9.67 GP1BA ITGA2B ITGB3 MPL
10 blood coagulation, intrinsic pathway GO:0007597 9.63 F2 F8 F9 GP1BA GP9 VWF
11 cell-substrate adhesion GO:0031589 9.59 ITGB3 VWF
12 regulation of blood coagulation GO:0030193 9.58 F2 GP1BA SERPINC1
13 positive regulation of blood coagulation GO:0030194 9.57 F2 F7
14 positive regulation of positive chemotaxis GO:0050927 9.56 F3 F7
15 negative regulation of fibrinolysis GO:0051918 9.55 F2 THBD
16 negative regulation of platelet activation GO:0010544 9.54 F2 THBD
17 blood coagulation, extrinsic pathway GO:0007598 9.48 F3 F7
18 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.46 F3 F7
19 thrombopoietin-mediated signaling pathway GO:0038163 9.43 MPL THPO
20 hemostasis GO:0007599 9.36 ADAMTS13 F2 F3 F7 F8 F9
21 cell adhesion GO:0007155 10 GP1BA GP9 ITGA2B ITGB3 VWF

Molecular functions related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.56 F2 F3 F7 F9
2 fibrinogen binding GO:0070051 8.96 ITGA2B ITGB3
3 protease binding GO:0002020 8.92 F3 ITGB3 SERPINC1 VWF
4 protein binding GO:0005515 10.09 ADAMTS13 F2 F3 F7 F8 F9

Sources for Blood Coagulation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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