MCID: BLD051
MIFTS: 47

Blood Coagulation Disease

Categories: Blood diseases

Aliases & Classifications for Blood Coagulation Disease

MalaCards integrated aliases for Blood Coagulation Disease:

Name: Blood Coagulation Disease 12 15
Blood Coagulation Disorders 76 44 73
Postpartum Coagulation Defect with Delivery 12
Postpartum Coagulation Defect 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1247
ICD10 33 D68.9 O72.3
ICD9CM 35 286
MeSH 44 D001778
NCIt 50 C2902
SNOMED-CT 68 64779008
UMLS 73 C0005779

Summaries for Blood Coagulation Disease

MalaCards based summary : Blood Coagulation Disease, also known as blood coagulation disorders, is related to inherited blood coagulation disease and antithrombin iii deficiency. An important gene associated with Blood Coagulation Disease is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include bone, testes and skin, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Coagulopathy (also called a bleeding disorder) is a condition in which the blood´┐Ż??s ability to... more...

Related Diseases for Blood Coagulation Disease

Diseases in the Blood Coagulation Disease family:

Inherited Blood Coagulation Disease

Diseases related to Blood Coagulation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 inherited blood coagulation disease 32.9 F2 F3 F7 F8 F9 GP1BA
2 antithrombin iii deficiency 31.7 F2 MTHFR SERPINC1
3 bleeding disorder, platelet-type, 16 31.7 ITGA2B ITGB3
4 acquired von willebrand syndrome 31.7 F8 F9 GP1BA VWF
5 prothrombin deficiency, congenital 31.7 F2 SERPINC1
6 pseudo-von willebrand disease 31.6 GP1BA GP1BB GP9 VWF
7 hemophilia b 31.5 F2 F3 F7 F8 F9 SERPINC1
8 factor v deficiency 31.5 F2 F3 F7 F8 F9 VWF
9 glanzmann thrombasthenia 31.2 F2 F3 F8 F9 GP1BA GP9
10 bernard-soulier syndrome 31.1 F2 F8 GP1BA GP1BB GP9 ITGA2B
11 thrombosis 29.0 ADAMTS13 F2 F3 F7 F8 F9
12 gray platelet syndrome 10.9
13 bleeding disorder, platelet-type, 17 10.9
14 scott syndrome 10.9
15 quebec platelet disorder 10.9
16 bleeding disorder, platelet-type, 12 10.9
17 platelet glycoprotein iv deficiency 10.9
18 bleeding disorder, platelet-type, 8 10.9
19 bleeding disorder, platelet-type, 14 10.9
20 bleeding disorder, platelet-type, 9 10.9
21 bleeding disorder, platelet-type, 11 10.9
22 bleeding disorder, platelet-type, 15 10.9
23 bleeding disorder, platelet-type, 18 10.9
24 bleeding disorder, platelet-type, 19 10.9
25 bleeding disorder, platelet-type, 20 10.9
26 factor v and factor viii, combined deficiency of, 1 10.9
27 factor v and factor viii, combined deficiency of, 2 10.9
28 hemorrhagic fever 10.3 F2 F3 SERPINC1
29 fainting 10.3 F8 VWF
30 unilateral absence of a pulmonary artery 10.3 THBD VWF
31 cerebral falx meningioma 10.3 F2 F3
32 intestinal impaction 10.3 F2 F3 SERPINC1
33 cerebral arteritis 10.3 F8 VWF
34 giant hemangioma 10.3 F2 F3 SERPINC1
35 bombay phenotype 10.3 ADAMTS13 VWF
36 sagittal sinus thrombosis 10.3 F2 F3 SERPINC1
37 blue toe syndrome 10.3 F2 F3 SERPINC1
38 heparin-induced thrombocytopenia 10.3 F3 SERPINC1
39 purpura fulminans 10.3 F2 F3 SERPINC1
40 brachydactyly, type d 10.3 F2 F8 VWF
41 factor viii deficiency 10.3 F2 F8 VWF
42 acquired hemophilia 10.3 F3 F8 F9
43 peripheral vertigo 10.3 F2 F3 SERPINC1
44 acquired hemophilia a 10.3 F3 F8 F9
45 cerebral sinovenous thrombosis 10.3 F2 F3
46 prothrombin deficiency 10.3 F2 F3 F7
47 hypersplenism 10.3 F2 SERPINC1 THPO
48 thrombocytopenia 3 10.3 MPL THPO
49 post-thrombotic syndrome 10.3 F2 F8 SERPINC1
50 splenic disease 10.3 F2 F3 THPO

Graphical network of the top 20 diseases related to Blood Coagulation Disease:



Diseases related to Blood Coagulation Disease

Symptoms & Phenotypes for Blood Coagulation Disease

GenomeRNAi Phenotypes related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.05 ITGB3
2 Decreased viability GR00106-A-0 10.05 MPL
3 Decreased viability GR00221-A-2 10.05 ITGB3
4 Decreased viability GR00221-A-4 10.05 ITGB3
5 Decreased viability GR00240-S-1 10.05 MPL
6 Decreased viability GR00402-S-2 10.05 ADAMTS13 ATAT1 F2 F3 F7 F8
7 no effect GR00402-S-1 9.62 ADAMTS13 ATAT1 F2 F3 F7 F8

MGI Mouse Phenotypes related to Blood Coagulation Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.19 ADAMTS13 ATAT1 F2 F3 F8 F9
2 homeostasis/metabolism MP:0005376 10.11 ADAMTS13 F2 F3 F7 F8 F9
3 cardiovascular system MP:0005385 10.02 F2 F3 F7 F9 ITGA2B ITGB3
4 embryo MP:0005380 9.92 F2 F3 F9 ITGA2B ITGB3 MPL
5 immune system MP:0005387 9.73 ADAMTS13 F2 F3 F8 F9 ITGA2B
6 mortality/aging MP:0010768 9.47 ADAMTS13 ATAT1 F2 F3 F7 F8

Drugs & Therapeutics for Blood Coagulation Disease

Search Clinical Trials , NIH Clinical Center for Blood Coagulation Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: blood coagulation disorders

Genetic Tests for Blood Coagulation Disease

Anatomical Context for Blood Coagulation Disease

MalaCards organs/tissues related to Blood Coagulation Disease:

41
Bone, Testes, Skin, Heart, Spinal Cord, Bone Marrow, Placenta

Publications for Blood Coagulation Disease

Articles related to Blood Coagulation Disease:

(show all 13)
# Title Authors Year
1
A User-Friendly App for Blood Coagulation Disorders. ( 29380340 )
2018
2
Possibly propylthiouracil-induced antineutrophilic cytoplasmic antibody-associated vasculitis manifested as blood coagulation disorders: A case report. ( 27741122 )
2016
3
Blood coagulation disorders in septic patients. ( 20364416 )
2010
4
Hereditary blood coagulation disorders: management and dental treatment. ( 16246926 )
2005
5
Assessing quality of life in individuals with hereditary blood coagulation disorders. ( 15233512 )
2004
6
Blood coagulation disorders during primary cytomegalovirus infection. ( 11570949 )
2001
7
Drug induced blood coagulation disorders. ( 11507526 )
1999
8
[Blood coagulation disorders observed in arteriosclerosis obliterans]. ( 8808808 )
1996
9
Acute intrinsic renal failure and blood coagulation disorders after a snakebite in a dog. ( 7474966 )
1995
10
Cancer in persons with inherited blood coagulation disorders. ( 573172 )
1979
11
Studies on blood coagulation disorders in domestic animals. Thrombelastograms of normal cattle and cattle affected with bracken poisoning. ( 1241061 )
1975
12
An evaluation of the partial thromboplastin time in the detection of blood coagulation disorders. ( 5937814 )
1966
13
Studies on blood coagulation disorders in experimental leptospirosis. ( 13472979 )
1957

Variations for Blood Coagulation Disease

Expression for Blood Coagulation Disease

Search GEO for disease gene expression data for Blood Coagulation Disease.

Pathways for Blood Coagulation Disease

Pathways related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 F2 F3 F7 F8 F9 GP1BA
2
Show member pathways
12.78 F2 F3 F7 F8 F9 SERPINC1
3
Show member pathways
12.13 GP1BA GP1BB GP9 ITGA2B ITGB3 VWF
4
Show member pathways
12.1 F2 ITGB3 PF4 THBD
5 12.02 GP1BA GP1BB GP9 ITGA2B ITGB3 VWF
6 12 F2 F3 F7 F8 F9 SERPINC1
7 11.96 GP1BA ITGA2B ITGB3 MPL THPO
8
Show member pathways
11.94 F2 F3 F7 F8 F9 GP1BA
9 11.83 GP1BA GP1BB GP9 ITGA2B ITGB3 THPO
10
Show member pathways
11.78 F2 F7 F9
11 11.68 F3 ITGB3 VWF
12 11.51 F2 GP1BB GP9 ITGA2B ITGB3 VWF
13 11.39 GP9 ITGA2B ITGB3
14
Show member pathways
11.27 F2 GP1BA GP1BB GP9 ITGA2B ITGB3
15 10.88 F2 F7 F9
16 10.85 GP1BA GP1BB GP9 VWF
17 10.71 GP1BA GP1BB GP9 VWF

GO Terms for Blood Coagulation Disease

Cellular components related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.73 F3 PF4 SERPINC1 VWF
2 cell surface GO:0009986 9.7 ADAMTS13 F3 GP1BA ITGA2B ITGB3 MPL
3 Golgi lumen GO:0005796 9.63 F2 F7 F9
4 platelet alpha granule lumen GO:0031093 9.58 F8 PF4 VWF
5 platelet alpha granule membrane GO:0031092 9.48 ITGA2B ITGB3
6 endoplasmic reticulum lumen GO:0005788 9.43 ADAMTS13 F2 F7 F8 F9 SERPINC1
7 extracellular space GO:0005615 9.36 ADAMTS13 F2 F3 F7 F8 F9
8 serine-type peptidase complex GO:1905286 9.26 F3 F7
9 plasma membrane GO:0005886 10.18 F2 F3 F7 F8 F9 GP1BA
10 extracellular region GO:0005576 10.02 ADAMTS13 F2 F3 F7 F8 F9

Biological processes related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.97 GP1BA GP1BB GP9 ITGA2B ITGB3 VWF
2 blood coagulation GO:0007596 9.97 ADAMTS13 F2 F3 F7 F8 F9
3 platelet activation GO:0030168 9.91 ADAMTS13 F2 F8 GP1BA GP1BB GP9
4 cell surface receptor signaling pathway GO:0007166 9.88 F2 GP1BA GP1BB MPL
5 ER to Golgi vesicle-mediated transport GO:0006888 9.83 F2 F7 F8 F9
6 cell-matrix adhesion GO:0007160 9.77 ADAMTS13 ITGA2B ITGB3
7 integrin-mediated signaling pathway GO:0007229 9.77 ADAMTS13 ITGA2B ITGB3
8 hemostasis GO:0007599 9.73 ADAMTS13 F2 F3 F7 F8 F9
9 platelet degranulation GO:0002576 9.72 F8 ITGA2B ITGB3 PF4 VWF
10 regulation of megakaryocyte differentiation GO:0045652 9.71 GP1BA ITGA2B PF4
11 protein processing GO:0016485 9.69 ADAMTS13 F3 F7
12 platelet aggregation GO:0070527 9.67 GP1BA ITGA2B ITGB3 MPL
13 cell-substrate adhesion GO:0031589 9.61 ITGB3 VWF
14 positive regulation of blood coagulation GO:0030194 9.58 F2 F7
15 regulation of blood coagulation GO:0030193 9.58 F2 GP1BA SERPINC1
16 positive regulation of positive chemotaxis GO:0050927 9.57 F3 F7
17 negative regulation of fibrinolysis GO:0051918 9.56 F2 THBD
18 negative regulation of platelet activation GO:0010544 9.55 F2 THBD
19 blood coagulation, extrinsic pathway GO:0007598 9.48 F3 F7
20 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.46 F3 F7
21 thrombopoietin-mediated signaling pathway GO:0038163 9.43 MPL THPO
22 blood coagulation, intrinsic pathway GO:0007597 9.17 F2 F8 F9 GP1BA GP1BB GP9

Molecular functions related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.56 F2 F3 F7 F9
2 fibrinogen binding GO:0070051 8.96 ITGA2B ITGB3
3 protease binding GO:0002020 8.92 F3 ITGB3 SERPINC1 VWF
4 protein binding GO:0005515 10.09 ADAMTS13 F2 F3 F7 F8 F9

Sources for Blood Coagulation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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