Blood Coagulation Disease

Categories: Blood diseases

Aliases & Classifications for Blood Coagulation Disease

MalaCards integrated aliases for Blood Coagulation Disease:

Name: Blood Coagulation Disease 12 15 17
Blood Coagulation Disorders 74 43 71
Postpartum Coagulation Defect with Delivery 12
Postpartum Coagulation Defect 12


External Ids:

Disease Ontology 12 DOID:1247
ICD9CM 34 286
MeSH 43 D001778
NCIt 49 C2902
SNOMED-CT 67 64779008
ICD10 32 D68.9 O72.3
UMLS 71 C0005779

Summaries for Blood Coagulation Disease

MalaCards based summary : Blood Coagulation Disease, also known as blood coagulation disorders, is related to inherited blood coagulation disease and factor xii deficiency. An important gene associated with Blood Coagulation Disease is U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Anti-inhibitor coagulant complex and Acenocoumarol have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and brain, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 74 Coagulopathy (also called a bleeding disorder) is a condition in which the blood's ability to coagulate... more...

Related Diseases for Blood Coagulation Disease

Diseases in the Blood Coagulation Disease family:

Inherited Blood Coagulation Disease

Diseases related to Blood Coagulation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 455)
# Related Disease Score Top Affiliating Genes
1 inherited blood coagulation disease 34.4 VWF THBD SERPINC1 PF4 ITGA2B GP1BA
2 factor xii deficiency 32.8 VWF SERPINC1 F9 F3
3 antithrombin iii deficiency 32.8 SERPINC1 PF4 F3 F2
4 prothrombin deficiency 32.7 SERPINC1 F9 F8 F7 F3 F2
5 factor vii deficiency 32.7 SERPINC1 F9 F8 F7 F3 F2
6 factor v deficiency 32.7 VWF F9 F8 F7 F3 F2
7 factor xiii deficiency 32.6 VWF SERPINC1 F9 F8 F7 F3
8 gray platelet syndrome 32.6 VWF THPO PF4 ITGA2B GP1BA CD40LG
9 factor viii deficiency 32.6 VWF ICOSLG F9 F8 F7 F3
10 acquired von willebrand syndrome 32.6 VWF U2AF1 GP1BA F9 F8 F7
11 factor xi deficiency 32.6 VWF THBD SERPINC1 F9 F8 F7
12 hemophilia b 32.5 VWF SERPINC1 PF4 ICOSLG F9 F8
13 bernard-soulier syndrome 32.5 VWF THPO ITGA2B GP1BA F9 F8
14 glanzmann thrombasthenia 32.5 VWF PF4 ITGA2B GP1BA F9 F8
15 prothrombin deficiency, congenital 32.4 SERPINC1 F2
16 hemophilia 31.5 F9 F8 F7
17 hemophilia a 31.2 VWF F9 F8 F7 F3
18 disseminated intravascular coagulation 31.1 VWF THBD SERPINC1 F9 F7 F3
19 liver cirrhosis 31.1 THPO SERPINC1 F3 F2 ADAMTS13
20 arteriosclerosis 31.1 THBD SERPINC1 ITGA2B GP1BA F3
21 von willebrand's disease 31.0 VWF PF4 GP1BA F9 F8 F7
22 heparin-induced thrombocytopenia 31.0 SERPINC1 PF4 F3 CD40LG
23 placental abruption 31.0 THBD SERPINC1 F2
24 collagen disease 30.9 VWF THBD H2AC18 CD40LG CCR6
25 factor x deficiency 30.8 F9 F7 F3 F2
26 varicose veins 30.7 VWF THBD SERPINC1 F2
27 homocystinuria 30.7 U2AF1 THBD SERPINC1 F8
28 portal hypertension 30.7 VWF THPO F3 F2 CD40LG ADAMTS13
29 deficiency anemia 30.7 U2AF1 THPO SERPINC1 H2AC18
30 thrombophilia due to thrombin defect 30.7 THBD SERPINC1 PF4 F8 F3 F2
31 thrombotic thrombocytopenic purpura 30.7 VWF THBD SERPINC1 F3 CD40LG ADAMTS13
32 thrombophilia 30.6 VWF THBD SERPINC1 PF4 F9 F8
33 thrombophlebitis 30.6 VWF SERPINC1 F8 F7 F3 F2
34 hellp syndrome 30.6 VWF THBD SERPINC1 F3 F2 CD40LG
35 thrombocytopenia 30.6 VWF U2AF1 THPO THBD SERPINC1 PF4
36 myeloma, multiple 30.6 U2AF1 ICOSLG H2AC18 F9 CD40LG CCR6
37 polycythemia vera 30.6 VWF U2AF1 THPO THBD PF4 MPL
38 thrombophilia due to activated protein c resistance 30.6 VWF THBD SERPINC1 PF4 F9 F8
39 thrombosis 30.6 VWF THBD SERPINC1 PF4 MPL ITGA2B
40 respiratory failure 30.6 THBD PF4 H2AC18 F3 F2 CD40LG
41 leukemia, acute myeloid 30.5 U2AF1 THPO MPL ITGA2B ICOSLG H2AC18
42 diabetes mellitus 30.4 VWF THBD SERPINC1 PF4 GP1BA F8
43 vascular disease 30.4 VWF THBD SERPINC1 PF4 ITGA2B GP1BA
45 meningococcemia 30.1 THBD SERPINC1
46 pseudo-von willebrand disease 11.1
47 bleeding disorder, platelet-type, 16 11.1
48 bleeding disorder, platelet-type, 17 11.1
49 high molecular weight kininogen deficiency 11.1
50 scott syndrome 11.1

Graphical network of the top 20 diseases related to Blood Coagulation Disease:

Diseases related to Blood Coagulation Disease

Symptoms & Phenotypes for Blood Coagulation Disease

MGI Mouse Phenotypes related to Blood Coagulation Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 ADAMTS13 CCR6 CD40LG F2 F3 F8
2 cardiovascular system MP:0005385 9.96 CCR6 CD40LG F2 F3 F7 F9
3 homeostasis/metabolism MP:0005376 9.86 ADAMTS13 CCR6 CD40LG F2 F3 F7
4 immune system MP:0005387 9.44 ADAMTS13 CCR6 CD40LG F2 F3 F8

Drugs & Therapeutics for Blood Coagulation Disease

Drugs for Blood Coagulation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 209)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Anti-inhibitor coagulant complex Approved, Investigational Phase 4
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
Tranexamic Acid Approved Phase 4 1197-18-8 5526
4 fluindione Approved, Investigational Phase 4 957-56-2
Phenindione Approved, Investigational Phase 4 83-12-5 4760
Protein C Approved Phase 4
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
Enoxaparin Approved Phase 4 9005-49-6 772
Dalteparin Approved Phase 4 9005-49-6
Apixaban Approved Phase 4 503612-47-3 10182969
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
Thrombin Approved, Investigational Phase 4
13 Deamino Arginine Vasopressin Phase 4
14 Vasopressins Phase 4
15 Arginine Vasopressin Phase 4
16 Hydroxyethyl Starch Derivatives Phase 4
17 Hemostatics Phase 4
18 Antifibrinolytic Agents Phase 4
19 Coagulants Phase 4
20 Fibrinolytic Agents Phase 4
21 polysaccharide-K Phase 4
22 Heparin, Low-Molecular-Weight Phase 4
23 Pharmaceutical Solutions Phase 4
24 Analgesics, Non-Narcotic Phase 4
25 Analgesics Phase 4
26 Cyclooxygenase Inhibitors Phase 4
27 Anti-Inflammatory Agents Phase 4
28 Antirheumatic Agents Phase 4
29 Anti-Inflammatory Agents, Non-Steroidal Phase 4
30 Ketorolac Tromethamine Phase 4
31 Thromboplastin Phase 4
32 Protamines Phase 4
Edoxaban Approved Phase 2, Phase 3 480449-70-5
Verapamil Approved Phase 2, Phase 3 52-53-9 2520
Quinidine Approved, Investigational Phase 2, Phase 3 56-54-2 441074
Fondaparinux Approved, Investigational Phase 3 104993-28-4
Polidocanol Approved Phase 2, Phase 3 9002-92-0
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
Phylloquinone Approved, Investigational Phase 2, Phase 3 84-80-0
Rivaroxaban Approved Phase 2, Phase 3 366789-02-8
Menadione Approved, Nutraceutical Phase 2, Phase 3 58-27-5 4055
Coumarin Experimental Phase 3 91-64-5 323
44 Menaquinone Investigational Phase 2, Phase 3 1182-68-9
Fibrinolysin Investigational Phase 3 9004-09-5
46 Anesthetics Phase 3
47 protein S Phase 3
48 Autoantibodies Phase 2, Phase 3
49 Vitamin K 1 Phase 3
50 Cathartics Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 377)
# Name Status NCT ID Phase Drugs
1 Prospective Non-randomized Trial Comparing Holmium Laser Enucleation of the Prostate Versus Greenlight Laser Photoselective Vaporization of the Prostate in Treating Benign Prostate Hyperplasia in Patients With Bleeding Tendency Unknown status NCT02293759 Phase 4
2 Placebo-Controlled, Randomized, Double-Blind Trial of Prophylactic Desmopressin in Heart Valve Surgery Unknown status NCT03343418 Phase 4 Desmopressin;Placebo
3 Effect of Colloid Versus Crystalloid on Coagulation in Elective Urological Surgery Unknown status NCT02270723 Phase 4 5% Human Albumin " Behring";Lactated Ringer
4 Study Using Plasma for Patients Requiring Emergency Surgery: A Randomized Pilot Trial of Early Plasma for Patients Undergoing Emergency Surgery for Hemorrhagic Shock Unknown status NCT01221389 Phase 4 Human Plasma
5 A Phase IV, Randomized, Single Center, Parallel Group Trial of Human Fibrinogen Concentrate (Haemocomplettan) in the Treatment of Dilutional Coagulopathy During Major Pediatric Surgery Completed NCT01487837 Phase 4 Human fibrinogen concentrate
6 Study of Safety and Efficacy of Antihemophilic Factor/Von Willebrand Factor Complex (Humate-P®) Using Individualized Dosing in Pediatric and Adult Surgical Subjects With Von Willebrand's Disease. Completed NCT00168090 Phase 4 Blood coagulation Factor VIII and vWF, human
7 Relationship of Edoxaban Plamsa Concentration and Blood Coagulation in Healthy Volunteers Using Standard Laboratory Tests and Viscoelastic Analysis Completed NCT03666650 Phase 4 Edoxaban 60 MG
8 rFVIIa (NovoSeven®) for Treatment of Mild/Moderate Joint Bleeds in Haemophilia Patients With Inhibitors: A Double-blind Study of a Single High Dose Versus Standard Multiple Doses of rFVIIa Completed NCT00571584 Phase 4 activated recombinant human factor VII
9 NovoSeven® (rFVIIa) by Single Dose for Home Treatment of Joint Bleeds in Haemophilia Patients With Inhibitors: A Pilot, Double-Blind Study Versus Standard Multiple Doses of NovoSeven® and Open-Label FEIBA® Completed NCT00108797 Phase 4 eptacog alfa (activated);Feiba VH
10 Effect of Colloid Versus Crystalloid on Coagulation in Elective Urological Surgery. A Randomised Clinical Study Completed NCT02009033 Phase 4 Lactated Ringer;Hydroxyethylstarch
11 A UK Open-label, Multicentre, Exploratory Phase II Study of INC424 for Patients With Primary Myelofibrosis (PMF) or Post Polycythaemia Myelofibrosis (PPV MF) or Post Essential Thrombocythaemia Myelofibrosis (PET-MF) Completed NCT01558739 Phase 4 INC424
12 The Hospital and Economics CERT: Project 1: The Clinical and Economic Implications of Genetic Testing for Warfarin Management Completed NCT00964353 Phase 4 Warfarin
13 Safety of Turoctocog Alfa for Prophylaxis and Treatment of Bleeding Episodes in Previously Treated Patients With Moderate or Severe Haemophilia A in India Completed NCT03449342 Phase 4 turoctocog alfa
14 An Open-Label, Randomized, Parallel, Multicenter Trial Comparing the Safety and Efficacy of rFVIIa When Administered as i.v. Bolus or i.v. Continuous Infusion to Hemophiliacs With Inhibitors During and After Major Surgery Completed NCT01561391 Phase 4 activated recombinant human factor VII;activated recombinant human factor VII;factor VIII
15 The Role of Human Fibrinogen Concentrate (RiaSTAP) in Decreasing Blood Loss and the Need for Component Blood Therapy in Infants Undergoing Cardiopulmonary Bypass. Completed NCT02822599 Phase 4 RiaStAP;Saline
16 Early Administration of Fibrinogen Concentrate in Polytraumatized Patients With Thromboelastometry Suggestive of Hypofibrinogenemia: a Randomized Feasibility Trial Completed NCT02864875 Phase 4 Fibrinogen concentrate
17 Comparison of Three Management Strategies for Post Cardiac Surgery Coagulopathy. Completed NCT00188747 Phase 4
18 Coagulopathy During Surgery for the Repair of Extent 4 Thoraco-Abdominal Aortic Aneurysms - Feasibility Study of the Use of Fibrinogen Concentrate by Infusion in Place of Fresh Frozen Plasma. Completed NCT00994045 Phase 4
19 Anticoagulant Clinic-based Shared-care Versus Usual Cate Management of Vitamin K Antagonist Therapy : the Open, Randomized Multicenter Study Completed NCT00966290 Phase 4 Anticoagulant (warfarin, acenocoumarol, fluindione);Anticoagulant (warfarin, acenocoumarol, fluindione)
20 The Assessment of the Minimal Effective and Tolerated Dose of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders Completed NCT00904709 Phase 4 tranexamic acid
21 Bivalirudin vs Heparin in Elderly Patients With Acute Coronary Syndrome Undergoing Elective Percutaneous Coronary Intervention Recruiting NCT04046029 Phase 4 Bivalirudin;Heparin
22 Prothrombin Complex Concentrate Versus Fresh Frozen Plasma to Correct Coagulation Disorders in Adult Neurosurgical Patients Recruiting NCT02777424 Phase 4 Prothrombin Complex Concentrate
23 Profilatic Fibrinogen Concentrate Reduces Postoperative Bleeding in Pediatric Cardiac Surgery With Cardiopulmonary Bypass: Randomized Study Recruiting NCT03884725 Phase 4 Fibrinogen Concentrate
24 COVID-19-associated Coagulopathy: Safety and Efficacy of Prophylactic Anticoagulation Therapy in Hospitalized Adults With COVID-19 Recruiting NCT04360824 Phase 4 Intermediate dose thromboprophylaxis;Standard of Care thromboprophylaxis
25 Evaluation of Residual Anti-Xa Activity As A Function Of Time Following The Last Treatment Dose of Enoxaparin In Patients Presenting For Elective Surgery Recruiting NCT03296033 Phase 4 Enoxaparin;Enoxaparin
26 A Prospective Study in Chinese Patients With Lower Extremity Ankle Fracture of Oral Anticoagulants to Prevent Venous Thromboembolism (VTE) Not yet recruiting NCT04128254 Phase 4 Apixaban Oral Tablet
27 Randomized Trial of Reinforcement Learning for the Dosing of Warfarin Not yet recruiting NCT03962400 Phase 4
28 Prospective Evaluation of the Effects of IV Ketorolac on Platelet Function Post-Cesarean Delivery Not yet recruiting NCT03805607 Phase 4 Ketorolac Tromethamine 30 MG/ML;Placebos
29 Indicación de transfusión de Hemoderivados en el Postoperatorio de cirugía Cardiaca Tras la implantación de un Sistema de monitorización de la coagulación a la Cabecera Del Paciente: Tromboelastometría Versus Protocolo Habitual de transfusión Terminated NCT01919840 Phase 4
30 A Pilot Study to Compare the Use of Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months Withdrawn NCT02774317 Phase 4
31 PRospective Evaluation Comparing Initiation of Warfarin StrategiEs (PRECISE): Pharmacogenetic-guided Versus Usual Care Withdrawn NCT00377143 Phase 4 Warfarin Dosing
32 Transfusion of Plasma Prior to Invasive Procedures Pilot Trial (TOPPIT) Unknown status NCT02561026 Phase 3
33 "Salvage Use" of Recombinant Activated Factor VII After Inadequate Haemostatic Response to Conventional Therapy in Complex Cardiac Surgery - a Randomised Placebo Controlled Trial Unknown status NCT00214656 Phase 3 Recombinant Activated Factor VII
34 An Open-label, Randomized, Multicenter Phase IIIb Study to Assess the Efficacy, Safety and Tolerance of BERIPLEX® P/N Compared With Plasma for Rapid Reversal of Coagulopathy Induced by Coumarin Derivatives in Subjects With Acute Major Bleeding Completed NCT00708435 Phase 3
35 Efficacy and Safety of NNC 0129-0000-1003 During Surgical Procedures in Patients With Haemophilia A Completed NCT01489111 Phase 3 turoctocog alfa pegol
36 An Open-label, Multi-centre, Un-controlled Trial to Assess Efficacy and Safety of NNC-0156-0000-0009 During Surgical Procedures in Patients With Haemophilia B Completed NCT01386528 Phase 3 nonacog beta pegol
37 Efficacy and Safety of B-Domain Deleted Recombinant Porcine Factor VIII (OBI-1) in the Treatment of Acquired Hemophilia A Due to Factor VIII Inhibitory Auto-antibodies Completed NCT01178294 Phase 2, Phase 3
38 Randomised, Double-Blind, Placebo Controlled, Multi-Centre, Parallel Groups Confirmatory Efficacy and Safety Trial of Activated Recombinant Factor VII (NovoSeven®/Niastase®) in Acute Intracerebral Haemorrhage Completed NCT00127283 Phase 3 eptacog alfa (activated)
39 A Multi-Centre, Open-Label, Single-Arm and Multiple Dosing Trial on Efficacy and Safety of Monthly Replacement Therapy With Recombinant Factor XIII (rFXIII) in Subjects With Congenital Factor XIII Deficiency Completed NCT00713648 Phase 3 catridecacog
40 Efficacy and Safety of NNC 0078-0000-0007 in Treatment of Acute Bleeding Episodes in Patients With Congenital Haemophilia and Inhibitors Completed NCT01392547 Phase 3 vatreptacog alfa (activated);eptacog alfa (activated)
41 A Multi-national Trial Evaluating Safety and Efficacy, Including Pharmacokinetics, of NNC 0129-0000-1003 When Administered for Treatment and Prophylaxis of Bleeding in Patients With Haemophilia A Completed NCT01480180 Phase 3 turoctocog alfa pegol
42 An Open-label, Randomized, Multicenter Phase IIIb Study to Assess the Efficacy, Safety and Tolerance of BERIPLEX® P/N Compared With Plasma for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Subjects Requiring an Urgent Surgical Procedure Completed NCT00803101 Phase 3
43 A Multi-Centre, Open-Label, Single-Arm, and Multiple Dosing Trial on Safety of Monthly Replacement Therapy With Recombinant Factor XIII (rFXIII) in Subjects With Congenital Factor XIII Deficiency Completed NCT00978380 Phase 3 catridecacog
44 A Phase 3b Trial Investigating the Pharmacokinetics and Safety Profile of a Single Intravenous Dose of rFXIII in Paediatric (1 to Less Than 6 Years Old) Subjects With Congenital FXIII A-subunit Deficiency Completed NCT01230021 Phase 3 catridecacog
45 A Randomised, Double-blind, Parallel Group, Placebo-controlled Comparison of Recombi-nant Factor VIIa (rFVIIa/ NovoSeven®) With Standard Haemostatic Replacement Therapy, and Standard Haemostatic Replacement Ther-apy Following Cardiac Bypass Surgery for Paediatric Congenital Heart Disease Completed NCT01562574 Phase 3 activated recombinant human factor VII;placebo
46 A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Assess the Safety and Efficacy of ART-123 in Subjects With Severe Sepsis and Coagulopathy. Completed NCT01598831 Phase 3 ART-123;Placebo
47 A Multinational, Open-Label, Non-Controlled Trial on Safety, Efficacy and Pharmacokinetics of NNC 0129-0000-1003 in Previously Treated Paediatric Patients With Severe Haemophilia A Completed NCT01731600 Phase 3 turoctocog alfa pegol
48 Safety and Efficacy of Turoctocog Alfa in Prevention and Treatment of Bleeds in Paediatric Previously Untreated Patients With Haemophilia A Completed NCT01493778 Phase 3 turoctocog alfa
49 Efficacy and Safety of Turoctocog Alfa for Prophylaxis and Treatment of Bleeding Episodes in Previously Treated Chinese Patients With Haemophilia A Completed NCT02938585 Phase 3 turoctocog alfa;turoctocog alfa
50 An Open-label, Uncontrolled, Single-arm, Multicenter Phase IIIb Study to Assess the Efficacy and Safety of BE1116 in Japanese Subjects Receiving Vitamin K Antagonist Therapy With an Elevated INR and Either Acute Major Bleeding or a Requirement for Urgent Reversal of Vitamin K Antagonist Therapy for a Surgical or Invasive Medical Procedure Completed NCT02281201 Phase 3

Search NIH Clinical Center for Blood Coagulation Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Tranexamic Acid

Cochrane evidence based reviews: blood coagulation disorders

Genetic Tests for Blood Coagulation Disease

Anatomical Context for Blood Coagulation Disease

MalaCards organs/tissues related to Blood Coagulation Disease:

Testes, Liver, Brain, Heart, Whole Blood, Prostate, Kidney

Publications for Blood Coagulation Disease

Articles related to Blood Coagulation Disease:

(show top 50) (show all 448)
# Title Authors PMID Year
Angina bullosa hemorrhagica, an uncommon oral disorder. Report of 4 cases. 61
32509235 2020
Blood Parameters in Treatment with Arsenic Trioxide in Acute Promyelocytic Leukemia: A Systematic Review. 61
32461798 2020
Study of the Association Between microRNA (miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T) Polymorphisms and the Risk of Recurrent Pregnancy Loss in Korean Women. 61
32224893 2020
Implications of Hemostasis Disorders in Patients with Critical Limb Ischemia-An In-Depth Comparison of Selected Factors. 61
32121363 2020
Coagulation System Disorders and Thrombosis Prophylaxis During Laparoscopic Fundoplications. 61
31517745 2019
Contribution of nascent cohesive fiber-fiber interactions to the non-linear elasticity of fibrin networks under tensile load. 61
31152942 2019
[Blood Coagulation Disorders During ECMO and LVAD Therapy]. 61
31212331 2019
Hepatectomy in patients with inherited blood coagulation disorders can be safely performed with adequate coagulation factor replacement. 61
31144420 2019
[The condition of the hemostatic system in acute severe peritonitis during remaxol therapy]. 61
30855593 2019
In vitro anticoagulant effect of Crassocephalum crepidioides leaf methanol extract and fractions on human blood. 61
31564995 2019
Suprachoroideal haemorrhage in postoperative period of antiglaucoma surgery, case report. 61
31537078 2019
Distinct plasma proteomic changes in male and female African American stroke patients. 61
31149323 2019
[A case of congenital bile acid synthesis disorder type 2 and literature review]. 61
30298497 2018
The characteristics of beta 2-glycoprotein I-dependent anticardiolipin antibody and blood coagulation status in subjects with classical biological false-positive syphilis reactions. 61
30005228 2018
Hemorrhagic Events in Adult Celiac Disease Patients. Case Report and Review of the Literature. 61
29557421 2018
Microbial serine protease inhibitors and their therapeutic applications. 61
28970170 2018
Correlations between lipid metabolism indices in patients with hypertension and hypothyroidism. 61
29729156 2018
Thrombosis in Thyroid Cancer. 61
29696039 2018
A User-Friendly App for Blood Coagulation Disorders. 61
29380340 2018
Hemostasis in Overt and Subclinical Hyperthyroidism. 61
29201071 2017
Hemostasis in Hypothyroidism and Autoimmune Thyroid Disorders. 61
29026409 2017
Thromboelastographic profile of goat blood after the experimental injury of the femoral artery and use of QuikClot gauze and Celox gauze dressings. 61
28525329 2017
Measuring coagulation in burns: an evidence-based systematic review. 61
29799542 2017
Novel combined strategy of obstetric haemorrhage management during caesarean section using intrauterine balloon tamponade. 61
26625194 2017
Treatment of Coagulopathy Related to Hepatic Insufficiency. 61
27635482 2016
Possibly propylthiouracil-induced antineutrophilic cytoplasmic antibody-associated vasculitis manifested as blood coagulation disorders: A case report. 61
27741122 2016
Protease-activated receptors - biology and role in cancer. 61
27383574 2016
Biomedical and Catalytic Applications of Gold and Silver-Gold Alloy Nanoparticles Biosynthesized Using Cell-Free Extract of Bacillus Safensis LAU 13: Antifungal, Dye Degradation, Anti-Coagulant and Thrombolytic Activities. 61
27164598 2016
Untangling the complexity of blood coagulation network: use of computational modelling in pharmacology and diagnostics. 61
26116831 2016
A portable blood plasma clot micro-elastometry device based on resonant acoustic spectroscopy. 61
26233406 2015
The influence of joint application of arsenic trioxide and daunorubicin on primary acute promyelocytic leukaemia cells and apoptosis and blood coagulation of cell strain. 61
26051726 2015
[Anesthesia and perioperative management for cesarean section in patient with factor XI deficiency: a case report]. 61
24743832 2014
A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry. 61
24512177 2014
Discovery of glycyrrhetinic acid as an orally active, direct inhibitor of blood coagulation factor xa. 61
24412029 2014
[Features of coagulative blood potential disorder in acute constitutional inflammatory response of septic tubo-ovarian formations]. 61
25971120 2014
[Overview--Recent therapeutic strategy for blood coagulation disorders]. 61
24492038 2014
TURP and PVP treatments are really similar? From subjective feeling to objective data. Pilot study (proof of concept) prospective randomized trial. 61
23427748 2012
Quantification of circulating D-dimer by peptide immunoaffinity enrichment and tandem mass spectrometry. 61
22788854 2012
[Bundle program of treatment for acute severe type high altitude disease]. 61
22748458 2012
[Neonatal renal vein thrombosis in a heterozygous carrier of both factor V Leiden and the MTHFR gene mutation]. 61
22361411 2012
[Epidural analgesia for surgical treatment of peritoneal carcinomatosis: a risky technique?]. 61
22154448 2012
Chapter 9: Analyses using disease ontologies. 61
23300417 2012
Non-cirrhotic portal hypertension with large regenerative nodules: a diagnostic challenge. 61
21633664 2011
D-dimer, plasminogen activator inhibitor-1, prothrombin fragments and protein C - role in prothrombotic state of colorectal cancer. 61
21391740 2011
Malignant tumours of colon and rectum from the blood clotting view. 61
22180990 2011
Spontaneous intramural duodenal haematoma with transient biliary obstruction and acute cholecystitis. 61
21221492 2010
Comparison of the fibrinogen Clauss assay and the fibrinogen PT derived method in patients with dysfibrinogenemia. 61
20947138 2010
Ophidian accident-related multi-organ failure: a case report. 61
25302518 2010
[Diagnosis and correction of thrombohemorrhagic complications in cardiosurgical patients in the early postoperative period]. 61
21400731 2010
In silico studies of blood coagulation proteins: from mosaic proteases to nonenzymatic cofactor inhibitors. 61
20083402 2010

Variations for Blood Coagulation Disease

Expression for Blood Coagulation Disease

Search GEO for disease gene expression data for Blood Coagulation Disease.

Pathways for Blood Coagulation Disease

Pathways related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
12.59 THBD SERPINC1 F9 F8 F7 F3
3 11.83 VWF ITGA2B GP1BA F2
5 11.77 VWF THBD SERPINC1 F9 F8 F7
Show member pathways
Show member pathways
8 11.34 VWF ITGA2B F2
9 10.72 F9 F7 F2
10 10.61 VWF GP1BA
11 10.48 VWF GP1BA

GO Terms for Blood Coagulation Disease

Cellular components related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.25 THBD SERPINC1 MPL ITGA2B ICOSLG GP1BA
2 extracellular region GO:0005576 10.03 VWF THPO SERPINC1 PF4 F9 F8
3 external side of plasma membrane GO:0009897 9.85 THBD ITGA2B ICOSLG F2 CD40LG CCR6
4 endoplasmic reticulum lumen GO:0005788 9.8 SERPINC1 F9 F8 F7 F2 ADAMTS13
5 cell surface GO:0009986 9.76 THBD MPL ITGA2B GP1BA F3 CD40LG
6 platelet alpha granule lumen GO:0031093 9.63 VWF PF4 F8
7 collagen-containing extracellular matrix GO:0062023 9.5 VWF SERPINC1 PF4 F9 F7 F3
8 serine-type peptidase complex GO:1905286 9.4 F7 F3
9 extracellular space GO:0005615 9.4 THPO THBD SERPINC1 PF4 GP1BA F9

Biological processes related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.81 F9 F8 F7 F2
2 regulation of megakaryocyte differentiation GO:0045652 9.7 PF4 ITGA2B GP1BA
3 platelet activation GO:0030168 9.7 VWF PF4 GP1BA F8 F2 CD40LG
4 protein processing GO:0016485 9.67 F7 F3 ADAMTS13
5 platelet degranulation GO:0002576 9.67 VWF PF4 ITGA2B F8
6 blood coagulation, intrinsic pathway GO:0007597 9.65 VWF GP1BA F9 F8 F2
7 blood coagulation GO:0007596 9.65 VWF THBD SERPINC1 GP1BA F9 F8
8 platelet aggregation GO:0070527 9.63 MPL ITGA2B GP1BA
9 positive regulation of blood coagulation GO:0030194 9.58 F7 F2
10 positive regulation of positive chemotaxis GO:0050927 9.57 F7 F3
11 negative regulation of fibrinolysis GO:0051918 9.56 THBD F2
12 cytolysis by host of symbiont cells GO:0051838 9.55 F2 CFHR2
13 negative regulation of platelet activation GO:0010544 9.54 THBD F2
14 regulation of blood coagulation GO:0030193 9.5 SERPINC1 GP1BA F2
15 thrombopoietin-mediated signaling pathway GO:0038163 9.48 THPO MPL
16 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.43 F7 F3
17 blood coagulation, extrinsic pathway GO:0007598 9.4 F7 F3
18 hemostasis GO:0007599 9.32 VWF THBD SERPINC1 GP1BA F9 F8

Molecular functions related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 VWF U2AF1 THBD SERPINC1 PF4 MPL
2 serine-type endopeptidase activity GO:0004252 8.92 F9 F7 F3 F2

Sources for Blood Coagulation Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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