MCID: BLD051
MIFTS: 50

Blood Coagulation Disease

Categories: Blood diseases

Aliases & Classifications for Blood Coagulation Disease

MalaCards integrated aliases for Blood Coagulation Disease:

Name: Blood Coagulation Disease 12 15
Blood Coagulation Disorders 76 44 73
Postpartum Coagulation Defect with Delivery 12
Postpartum Coagulation Defect 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1247
ICD10 33 D68.9 O72.3
ICD9CM 35 286
MeSH 44 D001778
NCIt 50 C2902
UMLS 73 C0005779

Summaries for Blood Coagulation Disease

MalaCards based summary : Blood Coagulation Disease, also known as blood coagulation disorders, is related to pseudo-von willebrand disease and antithrombin iii deficiency. An important gene associated with Blood Coagulation Disease is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Tranexamic Acid and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 A bleeding disorder (coagulopathy) is a condition that affects the way the blood clots. It is... more...

Related Diseases for Blood Coagulation Disease

Diseases in the Blood Coagulation Disease family:

Inherited Blood Coagulation Disease

Diseases related to Blood Coagulation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 pseudo-von willebrand disease 32.4 GP1BA VWF
2 antithrombin iii deficiency 32.3 F2 MTHFR SERPINC1
3 bleeding disorder, platelet-type, 16 32.3 ITGA2B ITGB3
4 acquired von willebrand syndrome 32.1 F8 F9 GP1BA VWF
5 gray platelet syndrome 32.1 CD40LG GP9 VWF
6 inherited blood coagulation disease 31.8 F2 F3 F7 F8 F9 GP1BA
7 hemophilia b 31.6 F2 F3 F7 F8 F9 SERPINC1
8 bernard-soulier syndrome 30.6 F2 F8 GP1BA GP9 ITGA2B ITGB3
9 glanzmann thrombasthenia 30.4 F2 F3 F8 F9 GP1BA GP9
10 thrombotic thrombocytopenic purpura, acquired 11.0 ADAMTS13 VWF
11 unilateral absence of a pulmonary artery 11.0 THBD VWF
12 intestinal impaction 11.0 F2 F3 SERPINC1
13 fainting 11.0 F8 VWF
14 mild hemophilia a 11.0 F8 VWF
15 leech infestation 11.0 F2 F3 SERPINC1
16 giant hemangioma 10.9 F2 F3 SERPINC1
17 sagittal sinus thrombosis 10.9 F2 F3 SERPINC1
18 angina pectoris 10.9 F3 SERPINC1 VWF
19 blue toe syndrome 10.9 F2 F3 SERPINC1
20 intracranial embolism 10.9 F2 F3 SERPINC1
21 cerebral falx meningioma 10.9 F2 F3
22 purpura fulminans 10.9 F2 F3 SERPINC1
23 peripheral vertigo 10.9 F2 F3 SERPINC1
24 factor viii deficiency 10.9 F2 F8 VWF
25 acquired hemophilia a 10.9 F3 F8 F9
26 hypersplenism 10.9 F2 SERPINC1 THPO
27 acquired hemophilia 10.9 F3 F8 F9
28 bombay phenotype 10.9 ADAMTS13 VWF
29 post-thrombotic syndrome 10.9 F2 F8 SERPINC1
30 von willebrand disease, type 2 10.9 F7 F8 VWF
31 intermittent claudication 10.9 F2 SERPINC1 VWF
32 anterior cranial fossa meningioma 10.9 F2 F3 F7
33 cerebral sinovenous thrombosis 10.9 F2 F3
34 cardiac tamponade 10.9 F2 F8 F9
35 intermediate coronary syndrome 10.9 F3 ITGA2B SERPINC1
36 thrombocytopenia 3 10.8 MPL THPO
37 severe hemophilia a 10.8 F2 F3 F8
38 thrombocythemia 1 10.8 MPL THPO
39 spotted fever 10.8 F2 THBD VWF
40 von willebrand disease, type 3 10.8 F8 GP1BA VWF
41 heparin-induced thrombocytopenia 10.8 CD40LG F3 SERPINC1
42 syphilitic meningitis 10.8 CD40LG SERPINC1
43 spinal cord infarction 10.8 F2 MTHFR SERPINC1
44 lateral sinus thrombosis 10.8 F9 MTHFR
45 amegakaryocytic thrombocytopenia, congenital 10.8 MPL THPO
46 dysfibrinogenemia 10.8 F2 SERPINC1 THBD
47 blood protein disease 10.8 F2 MTHFR SERPINC1
48 factor xii deficiency 10.8 F3 F9 SERPINC1 VWF
49 hantavirus pulmonary syndrome 10.8 CD40LG F2 F3
50 cerebral arteritis 10.8 CD40LG F8 VWF

Graphical network of the top 20 diseases related to Blood Coagulation Disease:



Diseases related to Blood Coagulation Disease

Symptoms & Phenotypes for Blood Coagulation Disease

MGI Mouse Phenotypes related to Blood Coagulation Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 VWF MPL PF4 SERPINC1 THBD THPO
2 homeostasis/metabolism MP:0005376 10.21 VWF MPL WDTC1 MTHFR PF4 SERPINC1
3 cardiovascular system MP:0005385 10.1 VWF SERPINC1 THBD F3 ITGB3 F7
4 embryo MP:0005380 9.97 MPL SERPINC1 THBD F3 ITGB3 F9
5 immune system MP:0005387 9.97 VWF MPL SERPINC1 THBD THPO F3
6 mortality/aging MP:0010768 9.83 VWF MPL WDTC1 MTHFR SERPINC1 THBD
7 reproductive system MP:0005389 9.28 MTHFR SERPINC1 THBD ITGB3 F8 ATAT1

Drugs & Therapeutics for Blood Coagulation Disease

Drugs for Blood Coagulation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 947)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 2,Phase 3,Not Applicable 1197-18-8 5526
2
Dalteparin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6
3
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
4 Nadroparin Approved, Investigational Phase 4,Not Applicable 9041-08-1
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-02-2 5743
6
Bortezomib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 179324-69-7 387447 93860
7
Melphalan Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 148-82-3 4053 460612
8
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
9
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
10
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
11
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 23214-92-8 31703
12
Zoledronic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 118072-93-8 68740
13
Warfarin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 81-81-2 6691 54678486
14
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
15
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
16
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
17
Zinc Approved, Investigational Phase 4,Phase 2,Phase 1 7440-66-6 23994
18
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
19
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 104987-11-3 445643 439492
20
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
21
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
22
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
23
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
24
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 26787-78-0 33613
25
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Phase 1 81103-11-9 84029
26
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
27
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
28
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable 446-86-6 2265
29
Hydroxychloroquine Approved Phase 4,Phase 1,Phase 2 118-42-3 3652
30
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
31
Lenalidomide Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 191732-72-6 216326
32
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
33
Apixaban Approved Phase 4,Phase 3,Phase 2,Not Applicable 503612-47-3 10182969
34
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4 6253
35
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
36
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 216974-75-3
37
Menthol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 2216-51-5 16666
38
Indomethacin Approved, Investigational Phase 4,Phase 3 53-86-1 3715
39
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7439-89-6 23925
40
Acenocoumarol Approved, Investigational Phase 4,Not Applicable 152-72-7 9052 54676537
41 fluindione Approved, Investigational Phase 4 957-56-2
42
Phenindione Approved, Investigational Phase 4 83-12-5 4760
43
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
44
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754
45
Progesterone Approved, Vet_approved Phase 4,Not Applicable 57-83-0 5994
46
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
47
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
48
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
49
Insulin Glargine Approved Phase 4 160337-95-1
50
Insulin Lispro Approved Phase 4 133107-64-9

Interventional clinical trials:

(show top 50) (show all 3989)
# Name Status NCT ID Phase Drugs
1 Trial of HoLEP vs. PVP in Treating BPH in Patients With Bleeding Tendency Unknown status NCT02293759 Phase 4
2 Treatment of Coagulopathy Trauma-induced Guided by Thromboelastography in Politrauma Patients. Unknown status NCT02864875 Phase 4 Fibrinogen concentrate
3 The Effect of Human Albumin on Coagulation Competence and Hemorrhage Unknown status NCT02270723 Phase 4 5% Human Albumin " Behring";Lactated Ringer
4 Study Using Plasma for Patients Requiring Emergency Surgery Unknown status NCT01221389 Phase 4 Human Plasma
5 TXA in the EMS on the Helicopter and the Ambulance Unknown status NCT02354885 Phase 4 Tranexamic Acid
6 Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD Unknown status NCT01531829 Phase 4 Recombinant tissue plasminogen activator (rt-PA);Low Molecular Weight Heparin
7 Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography Unknown status NCT02757170 Phase 4
8 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Unknown status NCT02216305 Phase 4
9 Safety and Effectiveness of a Balanced 3rd Generation HES Solution (Tetraspan®) After Cardiac Surgery Unknown status NCT01418521 Phase 4 Balanced hydroxyethyl starch solution;Ringer- albumin
10 Compare Efficacy and Simplicity of Regional Citrate Anticoagulation With Fixed Dose Versus Adjusted Citrate Program Unknown status NCT02663960 Phase 4
11 Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Unknown status NCT02314325 Phase 4 ADVATE [Antihemophilic Factor (Recombinant)];ADVATE [Antihemophilic Factor (Recombinant)]
12 Caffeic Acid Combining High-dose Dexamethasone in Management of ITP Unknown status NCT02556814 Phase 4 Caffeic acid tablets;Dexamethasone;placebo
13 Treatment With a Scheme With Low Doses of Bortezomib / Melphalan / Prednisone (MPV) in Patients With Multiple Myeloma Unknown status NCT02773550 Phase 4 Bortezomib;Melphalan;Prednisone
14 A Study of PAD Versus Velcade, Cyclophosphamide and Dexamethasone (VCD) Treatment in Subjects With Multiple Myeloma Unknown status NCT01868828 Phase 4 PAD;VCD
15 Efficacy Study of PAD and TAD in Newly Diagnosed Multiple Myeloma Unknown status NCT01249690 Phase 4 Bortezomib,Pirarubicin,Dexamethasone;Thalidomide,Pirarubicin,Dexamethasone
16 Stage I Multiple Myeloma Treatment Unknown status NCT00733538 Phase 4 zometa
17 Fibrinogen for Treatment of Pediatric Dilutional Coagulopathy. FibPaed Study. Completed NCT01487837 Phase 4 Human fibrinogen concentrate
18 The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders Completed NCT00904709 Phase 4 tranexamic acid
19 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
20 Comparison of Three Management Strategies for Post Cardiac Surgery Bleeding Completed NCT00188747 Phase 4
21 Conventional Versus Point-of-care Based Coagulation Management Completed NCT00997841 Phase 4
22 Anticoagulant Clinics and Vitamin K Antagonists Completed NCT00966290 Phase 4 Anticoagulant (warfarin, acenocoumarol, fluindione);Anticoagulant (warfarin, acenocoumarol, fluindione)
23 Effect of Colloid Versus Crystalloid on Coagulation in Elective Urological Surgery Completed NCT02009033 Phase 4 Lactated Ringer;Hydroxyethylstarch
24 Study of Safety and Efficacy of Antihemophilic Factor/Von Willebrand Factor Complex in Surgical Subjects With Von Willebrand Disease (vWD) Completed NCT00168090 Phase 4 Blood coagulation Factor VIII and vWF, human
25 BAY14-2222 Prophylaxis and Joint Function Improvement (Adults) Completed NCT00586521 Phase 4 Kogenate (BAY14-2222)
26 Safety and Efficacy of Activated Recombinant Human Factor VII in Haemophilia Patients With Inhibitors During and After Major Surgery Completed NCT01561391 Phase 4 activated recombinant human factor VII;activated recombinant human factor VII;factor VIII
27 High Dose of Activated Recombinant Human Factor VII for Treatment of Mild/Moderate Joint Bleeds in Haemophilia Patients With Inhibitors Completed NCT00571584 Phase 4 activated recombinant human factor VII
28 Trial of NovoSeven® in Haemophilia - Joint Bleeds Completed NCT00108797 Phase 4 eptacog alfa (activated);Feiba VH
29 Octaplas Pediatric Plasma Replacement Trial Completed NCT02050841 Phase 4
30 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy Completed NCT01269112 Phase 4
31 The Effect of Medication Timing on Anticoagulation Stability in Users of Warfarin: The "INRange" RCT Completed NCT02376803 Phase 4 Warfarin
32 Free Fatty Acid-Induced Hypertension in Obese Subjects With Type 2 Diabetes Completed NCT00738023 Phase 4 Rosiglitazone;Normal saline 0.9%;Intralipid 20%
33 International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage Completed NCT00928915 Phase 4 Prothrombin complex concentrate (PCC); fresh frozen plasma (FFP)
34 Nebulized Heparin and Salbutamol in Mechanically Ventilated Patients With AECOPD Completed NCT03333395 Phase 4 Nebulized heparin and salbutamol;Nebulized salbutamol
35 Effect of Low Dose Corticosteroids on Perioperative Markers of Thrombosis and Fibrinolysis in Total Knee Arthroplasty Completed NCT01815918 Phase 4 Hydrocortisone;Placebo
36 Antithrombotic Regimens and Outcome Completed NCT00448461 Phase 4 heparin;bivalirudin
37 Opioid-induced Hyperalgesia After Remifentanil Infusion Completed NCT01702389 Phase 4 Remifentanil
38 Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch Completed NCT01411891 Phase 4
39 Exploratory Phase II Study of INC424 Patients With Primary Myelofibrosis (PMF) or Post Polycythaemia Myelofibrosis (PPV MF) or Post Essential Thrombocythaemia Myelofibrosis (PET-MF) Completed NCT01558739 Phase 4 INC424
40 Survey of Inhibitors in Plasma-Product Exposed Toddlers Completed NCT01064284 Phase 4 PLASMA DERIVED Factor VIII;Recombinant FVIII
41 Phase 3/4 Study of a Recombinant Protein-Free Factor VIII (rAHF-PFM): Comparison of Continuous Infusion Versus Intermittent Bolus Infusion in Hemophilia A Subjects Undergoing Major Orthopedic Surgery Completed NCT00357656 Phase 4 Recombinant Protein-Free Factor VIII (rAHF-PFM);Recombinant Protein-Free Factor VIII (rAHF-PFM)
42 Dose-Response Study of Recombinant Factor VIII Manufactured Protein-Free (rAHF-PFM) in Patients With Hemophilia A Completed NCT00289536 Phase 4
43 IMMUNINE Pre-Treatment Study Completed NCT01128881 Phase 4
44 Early Whole Blood in Patients Requiring Transfusion After Major Trauma Completed NCT01227005 Phase 4
45 Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial Completed NCT01760967 Phase 4 Dexmedetomidine
46 Long-Term Effects of Insulin Plus Metformin Regimens on the Overall and Postprandial Glycemic Control of Patients With Type 2 Diabetes Completed NCT00191464 Phase 4 premeal insulin lispro mixtures;insulin glargine;metformin
47 Comparison of Different Prophylaxis Regimens for Moderate to Severe Hemophilia A Pediatric Patients Completed NCT02727647 Phase 4 FVIII;FVIII
48 Efficacy and Cost Effectiveness of Pharmacokinetic Dosing in Haemophilia A Completed NCT02697370 Phase 4 Pharmacokinetic based dosage change
49 PF-05208756, Moroctocog Alfa (AF-CC), Xyntha For Hemophilia A Completed NCT02492984 Phase 4 Intravenous infusions of Xyntha
50 China ADVATE PTP Study Completed NCT02170402 Phase 4

Search NIH Clinical Center for Blood Coagulation Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: blood coagulation disorders

Genetic Tests for Blood Coagulation Disease

Anatomical Context for Blood Coagulation Disease

MalaCards organs/tissues related to Blood Coagulation Disease:

41
Bone, Bone Marrow, T Cells, B Cells, Testes, Liver, Kidney

Publications for Blood Coagulation Disease

Articles related to Blood Coagulation Disease:

# Title Authors Year
1
[Blood coagulation disorders observed in arteriosclerosis obliterans]. ( 8808808 )
1996
2
[A newly discovered blood coagulation disorder. Resistance to activated protein C as a cause of thrombosis]. ( 8289554 )
1994
3
Hemorrhagic thrombocythemia; a blood coagulation disorder. ( 13354035 )
1956

Variations for Blood Coagulation Disease

Expression for Blood Coagulation Disease

Search GEO for disease gene expression data for Blood Coagulation Disease.

Pathways for Blood Coagulation Disease

Pathways related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 F2 F3 F7 F8 F9 GP1BA
2
Show member pathways
12.76 F2 F3 F7 F8 F9 SERPINC1
3
Show member pathways
12.1 F2 ITGB3 PF4 THBD
4
Show member pathways
12.05 GP1BA GP9 ITGA2B ITGB3 VWF
5 12 F2 F3 F7 F8 F9 SERPINC1
6 11.92 GP1BA GP9 ITGA2B ITGB3 VWF
7 11.87 GP1BA ITGA2B ITGB3 MPL THPO
8
Show member pathways
11.78 F2 F7 F9
9 11.75 GP1BA GP9 ITGA2B ITGB3 THPO
10
Show member pathways
11.75 F2 GP1BA GP9 ITGA2B ITGB3 MPL
11 11.68 F3 ITGB3 VWF
12
Show member pathways
11.57 F2 F3 F7 F8 F9 GP1BA
13 11.43 F2 GP9 ITGA2B ITGB3 VWF
14 11.39 GP9 ITGA2B ITGB3
15 10.88 F2 F7 F9
16 10.8 GP1BA GP9 VWF
17 10.63 GP1BA GP9 VWF

GO Terms for Blood Coagulation Disease

Cellular components related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ADAMTS13 CD40LG F2 F3 F7 F8
2 endoplasmic reticulum lumen GO:0005788 9.63 ADAMTS13 F2 F7 F8 F9 SERPINC1
3 Golgi lumen GO:0005796 9.61 F2 F7 F9
4 platelet alpha granule lumen GO:0031093 9.58 F8 PF4 VWF
5 platelet alpha granule membrane GO:0031092 9.46 ITGA2B ITGB3
6 serine-type peptidase complex GO:1905286 9.32 F3 F7
7 cell surface GO:0009986 9.23 ADAMTS13 CD40LG F3 GP1BA ITGA2B ITGB3
8 plasma membrane GO:0005886 10.18 CD40LG F2 F3 F7 F8 F9
9 extracellular region GO:0005576 10 ADAMTS13 CD40LG F2 F3 F7 F8

Biological processes related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.83 F2 F7 F8 F9
2 platelet activation GO:0030168 9.81 ADAMTS13 CD40LG F2 F8 GP1BA GP9
3 platelet degranulation GO:0002576 9.8 F8 ITGA2B ITGB3 PF4 VWF
4 cell-matrix adhesion GO:0007160 9.77 ADAMTS13 ITGA2B ITGB3
5 integrin-mediated signaling pathway GO:0007229 9.76 ADAMTS13 ITGA2B ITGB3
6 protein processing GO:0016485 9.73 ADAMTS13 F3 F7
7 blood coagulation, intrinsic pathway GO:0007597 9.73 F2 F8 F9 GP1BA GP9 VWF
8 blood coagulation GO:0007596 9.73 ADAMTS13 F2 F3 F7 F8 F9
9 regulation of megakaryocyte differentiation GO:0045652 9.71 GP1BA ITGA2B PF4
10 platelet aggregation GO:0070527 9.67 GP1BA ITGA2B ITGB3 MPL
11 signal peptide processing GO:0006465 9.65 F2 F7 F9
12 regulation of blood coagulation GO:0030193 9.63 F2 GP1BA SERPINC1
13 cell-substrate adhesion GO:0031589 9.61 ITGB3 VWF
14 peptidyl-glutamic acid carboxylation GO:0017187 9.61 F2 F7 F9
15 positive regulation of blood coagulation GO:0030194 9.59 F2 F7
16 positive regulation of positive chemotaxis GO:0050927 9.58 F3 F7
17 negative regulation of fibrinolysis GO:0051918 9.57 F2 THBD
18 negative regulation of platelet activation GO:0010544 9.55 F2 THBD
19 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.51 F3 F7
20 blood coagulation, extrinsic pathway GO:0007598 9.5 F3 F7 F9
21 thrombopoietin-mediated signaling pathway GO:0038163 9.49 MPL THPO
22 hemostasis GO:0007599 9.36 ADAMTS13 F2 F3 F7 F8 F9

Molecular functions related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.26 F2 F3 F7 F9
2 protease binding GO:0002020 8.92 F3 ITGB3 SERPINC1 VWF
3 protein binding GO:0005515 10.09 ADAMTS13 CD40LG F2 F3 F7 F8

Sources for Blood Coagulation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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