MCID: BLD158
MIFTS: 11

Blood Group, Chido/rodgers System

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Chido/rodgers System

MalaCards integrated aliases for Blood Group, Chido/rodgers System:

Name: Blood Group, Chido/rodgers System 57 29
Blood Group System, Chido/rodgers 39
Chido/rodgers Blood Group System 57

Classifications:



External Ids:

OMIM® 57 614374

Summaries for Blood Group, Chido/rodgers System

OMIM® : 57 The blood groups Chido (Ch) and Rodgers (Rg) are epitopes on the C4 protein, and polymorphisms associated with these epitopes may lead to the formation of antibodies to the Ch or Rg antigens in transfused patients. Identification of anti-Ch or anti-Rg is based on antibody neutralization with plasma from Ch-positive or Rg-positive individuals and lack of reactivity with qualified Ch-negative or Rg-negative red blood cells. The C4 protein occurs in 2 forms, C4A and C4B, which are encoded by 2 closely linked genes. C4A and C4B are expressed as single-chain precursors of 1,744 amino acids that are nearly identical, with amino acids differences at residues 1101 to 1106 distinguishing C4A from C4B. C4A and C4B are also distinguished by their expression of either the Ch antigen or the Rg antigen at residues 1188 to 1191, where the Ch1 epitope has ADLR and the Rg1 epitope has VDLL. C4A proteins usually carry the Rg antigens, and C4B proteins usually carry the Ch antigens, although in some haplotypes these associations are switched. Nine antigens have been described for the Ch/Rg system: 6 of high prevalence for Ch, 2 of high prevalence for Rg, and 1 of low prevalence, WH. Eight phenotypes of the Ch/Rg system have been established, with 88.2% of individuals having the Ch(1,2,3) Chido phenotype and 95.0% of individuals having the Rg(1,2) Rodgers phenotype (review by Mougey (2010)). (614374) (Updated 20-May-2021)

MalaCards based summary : Blood Group, Chido/rodgers System, also known as blood group system, chido/rodgers, is related to alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Blood Group, Chido/rodgers System is C4A (Complement C4A (Rodgers Blood Group)).

Related Diseases for Blood Group, Chido/rodgers System

Diseases related to Blood Group, Chido/rodgers System via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4

Symptoms & Phenotypes for Blood Group, Chido/rodgers System

Clinical features from OMIM®:

614374 (Updated 20-May-2021)

Drugs & Therapeutics for Blood Group, Chido/rodgers System

Search Clinical Trials , NIH Clinical Center for Blood Group, Chido/rodgers System

Genetic Tests for Blood Group, Chido/rodgers System

Genetic tests related to Blood Group, Chido/rodgers System:

# Genetic test Affiliating Genes
1 Blood Group, Chido/rodgers System 29 C4A

Anatomical Context for Blood Group, Chido/rodgers System

Publications for Blood Group, Chido/rodgers System

Articles related to Blood Group, Chido/rodgers System:

# Title Authors PMID Year
1
A review of the Chido/Rodgers blood group. 57
20795316 2010
2
Inherited structural polymorphism of the fourth component of human complement. 57
6932037 1980
3
Rga (Rodgers) and the HLA region: linkage and associations. 57
968900 1976
4
Linkage of Chido and HL-A. 57
4414486 1974
5
Chido-substance in plasma. 57
5081019 1972
6
A nebulous antibody responsible for cross-matching difficulties (Chido). 57
6016836 1967
7
An update on the Chido/Rodgers blood group system. 61
31935328 2019
8
Human erythrocyte antigen expression: its molecular bases. 61
9167305 1997

Variations for Blood Group, Chido/rodgers System

Expression for Blood Group, Chido/rodgers System

Search GEO for disease gene expression data for Blood Group, Chido/rodgers System.

Pathways for Blood Group, Chido/rodgers System

GO Terms for Blood Group, Chido/rodgers System

Sources for Blood Group, Chido/rodgers System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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