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CO
MCID: BLD165
MIFTS: 23

Blood Group, Colton System (CO)

Categories: Blood diseases, Genetic diseases
Genes Tissues Related diseases Publications
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Aliases & Classifications for Blood Group, Colton System

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MalaCards integrated aliases for Blood Group, Colton System:

Name: Blood Group, Colton System 56
Blood Group System, Colton 39
Colton Blood Group System 56
Aquaporin-1 Deficiency 56
Co 56

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 56 110450
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Summaries for Blood Group, Colton System

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OMIM : 56 Colton is a relatively simple blood group system consisting of a single polymorphism, with high and low incidence alleles represented by Co(a) and Co(b) antigens, respectively. A third antigen, Co3, is present on all cells, save those of the null phenotype, Co(a-b-) (summary by Daniels, 2002). The Colton-null phenotype, Co(a-b-), is also known as aquaporin-1 deficiency. (110450)

MalaCards based summary : Blood Group, Colton System, also known as blood group system, colton, is related to co-trimoxazole allergy and twin-to-twin transfusion syndrome. An important gene associated with Blood Group, Colton System is AQP1 (Aquaporin 1 (Colton Blood Group)). Affiliated tissues include heart, thyroid and t cells.

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Related Diseases for Blood Group, Colton System

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Diseases related to Blood Group, Colton System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 3220)
# Related Disease Score Top Affiliating Genes
1 co-trimoxazole allergy 12.5
2 twin-to-twin transfusion syndrome 11.7
3 attention deficit-hyperactivity disorder 11.4
4 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 11.4
5 chronic pain 11.4
6 developmental coordination disorder 11.4
7 hyperlipoproteinemia, type iii 11.3
8 hypotonia 11.3
9 hypospadias 11.3
10 whiplash 11.3
11 marinesco-sjogren syndrome 11.3
12 pulmonary alveolar microlithiasis 11.3
13 vater/vacterl association 11.3
14 powassan encephalitis 11.3
15 tabes dorsalis 11.3
16 vacterl association 11.3
17 meconium ileus 11.2
18 cobalt allergic contact dermatitis 11.2
19 cobalt allergic asthma 11.2
20 isolated duane retraction syndrome 11.2
21 delayed encephalopathy due to carbon monoxide poisoning 11.2
22 cortisone reductase deficiency 11.2
23 dystonia, dopa-responsive 11.0
24 endosteal hyperostosis, autosomal dominant 11.0
25 pelger-huet anomaly 11.0
26 trichodentoosseous syndrome 11.0
27 mitochondrial dna depletion syndrome 4a 11.0
28 fucosidosis 11.0
29 mitochondrial complex i deficiency, nuclear type 1 11.0
30 gonadoblastoma 11.0
31 lathosterolosis 11.0
32 erythroderma, ichthyosiform, congenital reticular 11.0
33 heart-hand syndrome, slovenian type 11.0
34 reynolds syndrome 11.0
35 aromatase deficiency 11.0
36 ectodermal dysplasia-syndactyly syndrome 1 11.0
37 hartsfield syndrome 11.0
38 chronic atrial and intestinal dysrhythmia 11.0
39 encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum 11.0
40 good syndrome 11.0
41 social emotional agnosia 11.0
42 vulvitis 11.0
43 cerebellar agenesis 11.0
44 paroxysmal exertion-induced dyskinesia 11.0
45 phacomatosis pigmentovascularis 11.0
46 floppy infant syndrome 11.0
47 infantile hypotonia 11.0
48 progressive locomotor ataxia 11.0
49 syphilitic spinal sclerosis 11.0
50 hepatitis c virus 10.6

Graphical network of the top 20 diseases related to Blood Group, Colton System:



Diseases related to Blood Group, Colton System
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Symptoms & Phenotypes for Blood Group, Colton System

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Clinical features from OMIM:

110450
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Drugs & Therapeutics for Blood Group, Colton System

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Search Clinical Trials , NIH Clinical Center for Blood Group, Colton System

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Genetic Tests for Blood Group, Colton System

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Anatomical Context for Blood Group, Colton System

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MalaCards organs/tissues related to Blood Group, Colton System:

40
Heart, Thyroid, T Cells, Bone, Kidney, Lung, Brain
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Publications for Blood Group, Colton System

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Articles related to Blood Group, Colton System:

(show all 16)
# Title Authors PMID Year
1
An AQP1 null allele in an Indian woman with Co(a-b-) phenotype and high-titer anti-Co3 associated with mild HDN. 61 56
11606828 2001
2
Decreased pulmonary vascular permeability in aquaporin-1-null humans. 56
11773634 2002
3
Defective urinary concentrating ability due to a complete deficiency of aquaporin-1. 56
11463012 2001
4
Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels. 56
7521540 1994
5
Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens. 56
7521882 1994
6
Linkage between the Colton blood group locus and ASSP11 on chromosome 7. 56
2341151 1990
7
Colton blood groups: indication of linkage with the Kidd (Jk) system as support for assignment to chromosome 7. 56
862214 1977
8
Colton blood groups in Canadian Caucasians: frequencies, inheritance and linkage analysis. 56
857421 1977
9
A functional AQP1 allele producing a Co(a-b-) phenotype revises and extends the Colton blood group system. 61
20492605 2010
10
A silenced allele in the Colton blood group system. 61
20345514 2010
11
A review of the Colton blood group system. 61
20795314 2010
12
Acute hemolytic transfusion reaction caused by anti-Coa. 61
15373591 2001
13
Case report: anti-Coa in a Co-(a+)-typed patient with chronic renal insufficiency. 61
9356672 1997
14
[Characteristics of anti-Coa antibodies of the Colton blood group system and their significance in hemotherapy]. 61
6673468 1983
15
Exclusion of the red blood cell antigen Fra from the Colton blood group system. 61
7368269 1980
16
[Delivery of a pregnant woman with a rare phenotype in the Colton-blood group system (author's transl)]. 61
422031 1979
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Variations for Blood Group, Colton System

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Expression for Blood Group, Colton System

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Search GEO for disease gene expression data for Blood Group, Colton System.
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Pathways for Blood Group, Colton System

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GO Terms for Blood Group, Colton System

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Sources for Blood Group, Colton System

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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