CO
MCID: BLD165
MIFTS: 21

Blood Group, Colton System (CO)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Colton System

MalaCards integrated aliases for Blood Group, Colton System:

Name: Blood Group, Colton System 57
Blood Group System, Colton 40
Colton Blood Group System 57
Aquaporin-1 Deficiency 57
Co 57

Classifications:



External Ids:

OMIM 57 110450

Summaries for Blood Group, Colton System

OMIM : 57 Colton is a relatively simple blood group system consisting of a single polymorphism, with high and low incidence alleles represented by Co(a) and Co(b) antigens, respectively. A third antigen, Co3, is present on all cells, save those of the null phenotype, Co(a-b-) (summary by Daniels, 2002). The Colton-null phenotype, Co(a-b-), is also known as aquaporin-1 deficiency. (110450)

MalaCards based summary : Blood Group, Colton System, also known as blood group system, colton, is related to co-trimoxazole allergy and twin-to-twin transfusion syndrome. An important gene associated with Blood Group, Colton System is AQP1 (Aquaporin 1 (Colton Blood Group)).

Related Diseases for Blood Group, Colton System

Diseases related to Blood Group, Colton System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 3197)
# Related Disease Score Top Affiliating Genes
1 co-trimoxazole allergy 12.4
2 twin-to-twin transfusion syndrome 11.7
3 attention deficit-hyperactivity disorder 11.4
4 chronic pain 11.4
5 pulmonary alveolar microlithiasis 11.4
6 developmental coordination disorder 11.4
7 hyperlipoproteinemia, type iii 11.3
8 hypotonia 11.3
9 hypospadias 11.3
10 whiplash 11.3
11 marinesco-sjogren syndrome 11.3
12 vater/vacterl association 11.3
13 tabes dorsalis 11.3
14 vacterl association 11.3
15 meconium ileus 11.2
16 cobalt allergic contact dermatitis 11.2
17 cobalt allergic asthma 11.2
18 isolated duane retraction syndrome 11.2
19 delayed encephalopathy due to carbon monoxide poisoning 11.2
20 cortisone reductase deficiency 11.2
21 dystonia, dopa-responsive 11.0
22 pelger-huet anomaly 11.0
23 trichodentoosseous syndrome 11.0
24 mitochondrial dna depletion syndrome 4a 11.0
25 fucosidosis 11.0
26 mitochondrial complex i deficiency, nuclear type 1 11.0
27 gonadoblastoma 11.0
28 lathosterolosis 11.0
29 erythroderma, ichthyosiform, congenital reticular 11.0
30 heart-hand syndrome, slovenian type 11.0
31 reynolds syndrome 11.0
32 aromatase deficiency 11.0
33 ectodermal dysplasia-syndactyly syndrome 1 11.0
34 hartsfield syndrome 11.0
35 chronic atrial and intestinal dysrhythmia 11.0
36 encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum 11.0
37 powassan encephalitis 11.0
38 good syndrome 11.0
39 social emotional agnosia 11.0
40 vulvitis 11.0
41 cerebellar agenesis 11.0
42 combined immunodeficiency due to partial rag1 deficiency 11.0
43 paroxysmal exertion-induced dyskinesia 11.0
44 phacomatosis pigmentovascularis 11.0
45 worth type autosomal dominant osteosclerosis 11.0
46 floppy infant syndrome 11.0
47 infantile hypotonia 11.0
48 progressive locomotor ataxia 11.0
49 syphilitic spinal sclerosis 11.0
50 hepatitis c virus 10.6

Graphical network of the top 20 diseases related to Blood Group, Colton System:



Diseases related to Blood Group, Colton System

Symptoms & Phenotypes for Blood Group, Colton System

Clinical features from OMIM:

110450

Drugs & Therapeutics for Blood Group, Colton System

Search Clinical Trials , NIH Clinical Center for Blood Group, Colton System

Genetic Tests for Blood Group, Colton System

Anatomical Context for Blood Group, Colton System

Publications for Blood Group, Colton System

Articles related to Blood Group, Colton System:

(show all 16)
# Title Authors PMID Year
1
An AQP1 null allele in an Indian woman with Co(a-b-) phenotype and high-titer anti-Co3 associated with mild HDN. 38 8
11606828 2001
2
Decreased pulmonary vascular permeability in aquaporin-1-null humans. 8
11773634 2002
3
Defective urinary concentrating ability due to a complete deficiency of aquaporin-1. 8
11463012 2001
4
Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels. 8
7521540 1994
5
Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens. 8
7521882 1994
6
Linkage between the Colton blood group locus and ASSP11 on chromosome 7. 8
2341151 1990
7
Colton blood groups: indication of linkage with the Kidd (Jk) system as support for assignment to chromosome 7. 8
862214 1977
8
Colton blood groups in Canadian Caucasians: frequencies, inheritance and linkage analysis. 8
857421 1977
9
A functional AQP1 allele producing a Co(a-b-) phenotype revises and extends the Colton blood group system. 38
20492605 2010
10
A silenced allele in the Colton blood group system. 38
20345514 2010
11
A review of the Colton blood group system. 38
20795314 2010
12
Acute hemolytic transfusion reaction caused by anti-Coa. 38
15373591 2001
13
Case report: anti-Coa in a Co-(a+)-typed patient with chronic renal insufficiency. 38
9356672 1997
14
[Characteristics of anti-Coa antibodies of the Colton blood group system and their significance in hemotherapy]. 38
6673468 1983
15
Exclusion of the red blood cell antigen Fra from the Colton blood group system. 38
7368269 1980
16
[Delivery of a pregnant woman with a rare phenotype in the Colton-blood group system (author's transl)]. 38
422031 1979

Variations for Blood Group, Colton System

Expression for Blood Group, Colton System

Search GEO for disease gene expression data for Blood Group, Colton System.

Pathways for Blood Group, Colton System

GO Terms for Blood Group, Colton System

Sources for Blood Group, Colton System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
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38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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