CROM
MCID: BLD155
MIFTS: 23

Blood Group, Cromer System (CROM)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Cromer System

MalaCards integrated aliases for Blood Group, Cromer System:

Name: Blood Group, Cromer System 57
Cromer Blood Group System 57 29 6
Blood Group System, Cromer 39
Crom 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal recessive

Miscellaneous:
some patients are clinically asymptomatic


HPO:

31
blood group, cromer system:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM® 57 613793
MedGen 41 C1292305
SNOMED-CT via HPO 68 22542007 258211005 66972006

Summaries for Blood Group, Cromer System

OMIM® : 57 The Cromer blood group system (CROM) consists of 12 high-prevalence and 3 low-prevalence antigens that reside on decay-accelerating factor (DAF, or CD55; 125240), a regulator of complement activation. Nearly all Cromer antigens result from SNPs in the DAF gene. The red blood cells (RBCs) of people with the Cromer-null phenotype, Inab, lack DAF but do not appear to show increased susceptibility to hemolysis. Antibodies to Cromer antigens are rarely encountered, although evidence suggests that the antibodies may cause accelerated destruction of transfused RBCs. Cromer system antibodies are not associated with hemolytic disease of the newborn, because placenta is a rich source of fetally derived DAF, which is thought to absorb the antibodies (review by Storry et al., 2010). The Inab phenotype is associated with CHAPLE syndrome (226300) in some individuals. (613793) (Updated 05-Apr-2021)

MalaCards based summary : Blood Group, Cromer System, also known as cromer blood group system, is related to placenta accreta and radiculopathy. An important gene associated with Blood Group, Cromer System is CD55 (CD55 Molecule (Cromer Blood Group)). The drugs Carbon monoxide and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include placenta, and related phenotype is protein-losing enteropathy.

Wikipedia : 73 Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is... more...

Related Diseases for Blood Group, Cromer System

Diseases related to Blood Group, Cromer System via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 placenta accreta 10.2
2 radiculopathy 10.0
3 whiplash 10.0

Symptoms & Phenotypes for Blood Group, Cromer System

Human phenotypes related to Blood Group, Cromer System:

31
# Description HPO Frequency HPO Source Accession
1 protein-losing enteropathy 31 very rare (1%) HP:0002243

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Abdomen Gastrointestinal:
protein-losing enteropathy (in some patients)
gastrointestinal tumors (in some patients)

Hematology:
red blood cells lack some ('dr(a-)') or all ('inab') of the cromer blood group antigens

Neoplasia:
gastrointestinal tumors (in some patients)

Clinical features from OMIM®:

613793 (Updated 05-Apr-2021)

Drugs & Therapeutics for Blood Group, Cromer System

Drugs for Blood Group, Cromer System (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carbon monoxide Approved, Investigational 630-08-0 281
2 Neurotransmitter Agents
3 Antimetabolites

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Markers for Glycaemic Control and Continuous Glucose Monitoring in Persons With Type 2 Diabetes on Chronic Haemodialysis Completed NCT03909269
2 Defining a Standard Set of Value-Based Patient-Centered Outcomes for Endometriosis: A Delphi Study Conducted by the Study Group VALue Based HEalth CaRe In Endometriosis (VALHERIE). Not yet recruiting NCT04820582

Search NIH Clinical Center for Blood Group, Cromer System

Genetic Tests for Blood Group, Cromer System

Genetic tests related to Blood Group, Cromer System:

# Genetic test Affiliating Genes
1 Cromer Blood Group System 29 CD55

Anatomical Context for Blood Group, Cromer System

MalaCards organs/tissues related to Blood Group, Cromer System:

40
Placenta

Publications for Blood Group, Cromer System

Articles related to Blood Group, Cromer System:

(show all 30)
# Title Authors PMID Year
1
Molecular cloning and characterization of decay-accelerating factor deficiency in Cromer blood group Inab phenotype. 57 6 61
9427725 1998
2
Dr(a-) polymorphism of decay accelerating factor. Biochemical, functional, and molecular characterization and production of allele-specific transfectants. 57 6
1710232 1991
3
A possible null phenotype in the Cromer blood group complex. 57 6
7123631 1982
4
The Cromer blood group system: a review. 57 61
21214297 2010
5
Disappearance of antibodies to Cromer blood group system antigens during mid pregnancy. 61 57
8837357 1996
6
CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis. 6
28657829 2017
7
Case report and literature review: transient Inab phenotype and an agglutinating anti-IFC in a patient with a gastrointestinal problem. 57
16965581 2006
8
Decay-accelerating factor (CD55) deficiency phenotypes in Japanese. 6
9675792 1998
9
Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. 57
7519480 1994
10
Biochemical studies on red blood cells from a patient with the Inab phenotype (decay-accelerating factor deficiency). 57
1720702 1991
11
A family showing inheritance of the Inab phenotype. 57
3420669 1988
12
A second Dr(a-) proposita with anti-Dra and a family with the Dr(a-) phenotype in two generations. 57
3810829 1987
13
A "new" phenotype confirming a relationship between Cra and Tca. 57
6695433 1984
14
CORS (CROM20): A new high-prevalence antigen in the Cromer blood group system. 61
32897629 2020
15
Impact of using genotyping to predict SERF negative phenotype in Thai blood donor populations. 61
32408415 2020
16
A challenging case of pregnancy with placenta accreta and very rare irregular antibodies versus Cromer blood group system: a case report. 61
25975935 2015
17
Three new high-prevalence antigens in the Cromer blood group system. 61
17725726 2007
18
Analysis of SERF in Thai blood donors. 61
15954807 2005
19
Persistent anti-Dra in two pregnancies. 61
16178671 2005
20
Novel molecular basis of an Inab phenotype. 61
15954804 2005
21
Review: Cromer and DAF: role in health and disease. 61
15954803 2005
22
SERF: a new antigen in the Cromer blood group system. 61
15285728 2004
23
GUTI: a new antigen in the Cromer blood group system. 61
12675719 2003
24
Acquired and transient RBC CD55 deficiency (Inab phenotype) and anti-IFC. 61
12421218 2002
25
The Cromer blood group system: a review. 61
15373545 2002
26
Molecular basis of Cromer blood group antigens. 61
10686005 2000
27
Hemolytic transfusion reaction due to anti-Tc(a). 61
10533820 1999
28
Hemagglutination inhibition of Cromer blood group antibodies with soluble recombinant decay-accelerating factor. 61
9595014 1998
29
The monoclonal antibody-specific immobilization of erythrocyte antigens assay (MAIEA) in the investigation of human red-cell antigens and their associated membrane proteins. 61
9316217 1997
30
A second example of anti-Esa, an antibody to a high-incidence Cromer antigen. 61
15387735 1996

Variations for Blood Group, Cromer System

ClinVar genetic disease variations for Blood Group, Cromer System:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CD55 NM_000574.5(CD55):c.261G>A (p.Trp87Ter) SNV Affects 16871 rs121909603 GRCh37: 1:207495887-207495887
GRCh38: 1:207322542-207322542
2 CD55 NM_000574.5(CD55):c.203G>A (p.Ser68Asn) SNV Affects 224614 rs869312818 GRCh37: 1:207495829-207495829
GRCh38: 1:207322484-207322484
3 CD55 NM_000574.5(CD55):c.263C>A (p.Ser88Ter) SNV Affects 16872 rs1131690771 GRCh37: 1:207495889-207495889
GRCh38: 1:207322544-207322544

Expression for Blood Group, Cromer System

Search GEO for disease gene expression data for Blood Group, Cromer System.

Pathways for Blood Group, Cromer System

GO Terms for Blood Group, Cromer System

Sources for Blood Group, Cromer System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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