CROM
MCID: BLD155
MIFTS: 19

Blood Group, Cromer System (CROM)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Cromer System

MalaCards integrated aliases for Blood Group, Cromer System:

Name: Blood Group, Cromer System 57
Cromer Blood Group System 57 29 6
Blood Group System, Cromer 40
Crom 57

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive

Miscellaneous:
some patients are clinically asymptomatic


Classifications:



External Ids:

OMIM 57 613793
MedGen 42 C1292305
SNOMED-CT via HPO 69 22542007 66972006

Summaries for Blood Group, Cromer System

OMIM : 57 The Cromer blood group system (CROM) consists of 12 high-prevalence and 3 low-prevalence antigens that reside on decay-accelerating factor (DAF, or CD55; 125240), a regulator of complement activation. Nearly all Cromer antigens result from SNPs in the DAF gene. The red blood cells (RBCs) of people with the Cromer-null phenotype, Inab, lack DAF but do not appear to show increased susceptibility to hemolysis. Antibodies to Cromer antigens are rarely encountered, although evidence suggests that the antibodies may cause accelerated destruction of transfused RBCs. Cromer system antibodies are not associated with hemolytic disease of the newborn, because placenta is a rich source of fetally derived DAF, which is thought to absorb the antibodies (review by Storry et al., 2010). The Inab phenotype is associated with CHAPLE syndrome (226300) in some individuals. (613793)

MalaCards based summary : Blood Group, Cromer System, also known as cromer blood group system, is related to placenta accreta and radiculopathy. An important gene associated with Blood Group, Cromer System is CD55 (CD55 Molecule (Cromer Blood Group)). Affiliated tissues include placenta, and related phenotype is protein-losing enteropathy.

Related Diseases for Blood Group, Cromer System

Diseases related to Blood Group, Cromer System via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 placenta accreta 10.1
2 radiculopathy 10.1
3 whiplash 10.1

Symptoms & Phenotypes for Blood Group, Cromer System

Symptoms via clinical synopsis from OMIM:

57
Abdomen Gastrointestinal:
protein-losing enteropathy (in some patients)
gastrointestinal tumors (in some patients)

Hematology:
red blood cells lack some ('dr(a-)') or all ('inab') of the cromer blood group antigens

Neoplasia:
gastrointestinal tumors (in some patients)


Clinical features from OMIM:

613793

Human phenotypes related to Blood Group, Cromer System:

32
# Description HPO Frequency HPO Source Accession
1 protein-losing enteropathy 32 very rare (1%) HP:0002243

Drugs & Therapeutics for Blood Group, Cromer System

Search Clinical Trials , NIH Clinical Center for Blood Group, Cromer System

Genetic Tests for Blood Group, Cromer System

Genetic tests related to Blood Group, Cromer System:

# Genetic test Affiliating Genes
1 Cromer Blood Group System 29 CD55

Anatomical Context for Blood Group, Cromer System

MalaCards organs/tissues related to Blood Group, Cromer System:

41
Placenta

Publications for Blood Group, Cromer System

Articles related to Blood Group, Cromer System:

# Title Authors Year
1
A challenging case of pregnancy with placenta accreta and very rare irregular antibodies versus Cromer blood group system: a case report. ( 25975935 )
2015
2
The Cromer blood group system: a review. ( 21214297 )
2010
3
Three new high-prevalence antigens in the Cromer blood group system. ( 17725726 )
2007
4
SERF: a new antigen in the Cromer blood group system. ( 15285728 )
2004
5
GUTI: a new antigen in the Cromer blood group system. ( 12675719 )
2003
6
The Cromer blood group system: a review. ( 15373545 )
2002
7
Disappearance of antibodies to Cromer blood group system antigens during mid pregnancy. ( 8837357 )
1996

Variations for Blood Group, Cromer System

ClinVar genetic disease variations for Blood Group, Cromer System:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CD55 NM_000574.4(CD55): c.263C> A (p.Ser88Ter) single nucleotide variant Affects rs1131690771 GRCh38 Chromosome 1, 207322544: 207322544
2 CD55 NM_000574.4(CD55): c.261G> A (p.Trp87Ter) single nucleotide variant Affects rs121909603 GRCh37 Chromosome 1, 207495887: 207495887
3 CD55 NM_000574.4(CD55): c.261G> A (p.Trp87Ter) single nucleotide variant Affects rs121909603 GRCh38 Chromosome 1, 207322542: 207322542
4 CD55 NM_000574.4(CD55): c.263C> A (p.Ser88Ter) single nucleotide variant Affects rs1131690771 GRCh37 Chromosome 1, 207495889: 207495889
5 CD55 NM_000574.4(CD55): c.203G> A (p.Ser68Asn) single nucleotide variant Affects rs869312818 GRCh37 Chromosome 1, 207495829: 207495829
6 CD55 NM_000574.4(CD55): c.203G> A (p.Ser68Asn) single nucleotide variant Affects rs869312818 GRCh38 Chromosome 1, 207322484: 207322484

Expression for Blood Group, Cromer System

Search GEO for disease gene expression data for Blood Group, Cromer System.

Pathways for Blood Group, Cromer System

GO Terms for Blood Group, Cromer System

Sources for Blood Group, Cromer System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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