DO
MCID: BLD163
MIFTS: 27

Blood Group, Dombrock System (DO)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Dombrock System

MalaCards integrated aliases for Blood Group, Dombrock System:

Name: Blood Group, Dombrock System 58 6
Dombrock Blood Group System 58
Do 58

Classifications:



External Ids:

OMIM 58 616060

Summaries for Blood Group, Dombrock System

OMIM : 58 The DO blood group was discovered with serologic tests of blood and named after the original DO(a) serum donor in 1965. Nearly a decade passed before the discovery of the antithetical antigen, DO(b). The DO(a) and DO(b) antigens reside on a glycosylphosphatidylinositol (GPI)-anchored red blood cell (RBC) membrane glycoprotein, ART4, that also carries 3 high-incidence antigens, Gregory (Gy(a)), Holley (Hy), and Joseph (Jo(a)). The DO blood group is not associated with hemolytic disease of the newborn, but severe hemolytic transfusion reactions due to the presence of anti-DO antibodies have been reported among adults (summary by Gubin et al. (2000) and Lucien et al. (2002)). (616060)

MalaCards based summary : Blood Group, Dombrock System, also known as dombrock blood group system, is related to stocco dos santos x-linked mental retardation syndrome and stocco dos santos syndrome. An important gene associated with Blood Group, Dombrock System is ART4 (ADP-Ribosyltransferase 4 (Dombrock Blood Group)). Affiliated tissues include heart, kidney and liver.

Related Diseases for Blood Group, Dombrock System

Diseases related to Blood Group, Dombrock System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2689)
# Related Disease Score Top Affiliating Genes
1 stocco dos santos x-linked mental retardation syndrome 12.6
2 stocco dos santos syndrome 12.4
3 chronic fatigue syndrome 11.2
4 alzheimer disease 11.2
5 dementia, lewy body 11.2
6 obsessive-compulsive disorder 11.2
7 cerebral palsy 11.2
8 myelodysplastic syndrome 11.2
9 trichomoniasis 11.2
10 esophagitis, eosinophilic, 1 11.2
11 arthrogryposis and ectodermal dysplasia 11.1
12 anophthalmia megalocornea cardiopathy skeletal anomalies 11.1
13 fatty liver disease 11.1
14 rickets 11.1
15 osteoporosis 11.1
16 learning disability 11.1
17 diabetes mellitus, noninsulin-dependent 11.1
18 hemochromatosis, type 1 11.1
19 zika fever 11.1
20 tonsillitis 11.1
21 vaginitis 11.1
22 y chromosome infertility 11.1
23 acute flaccid myelitis 11.1
24 myocardial infarction 11.1
25 gallbladder disease 1 11.1
26 depression 11.1
27 migraine with or without aura 1 11.1
28 parkinson disease, late-onset 11.1
29 neural tube defects 11.1
30 dementia 11.0
31 heart disease 11.0
32 schizophrenia 11.0
33 apnea, obstructive sleep 11.0
34 cholera 11.0
35 primary biliary cholangitis 11.0
36 genital herpes 11.0
37 premature ovarian failure 1 11.0
38 cystic kidney disease 11.0
39 monoclonal gammopathy of uncertain significance 11.0
40 cerebral cavernous malformations 11.0
41 leigh syndrome 11.0
42 duarte variant galactosemia 11.0
43 diarrhea 11.0
44 alacrima, achalasia, and mental retardation syndrome 11.0
45 pulmonary embolism 11.0
46 sudden infant death syndrome 11.0
47 stroke, ischemic 11.0
48 carpal tunnel syndrome 11.0
49 pulmonary hypertension 11.0
50 pertussis 11.0

Graphical network of the top 20 diseases related to Blood Group, Dombrock System:



Diseases related to Blood Group, Dombrock System

Symptoms & Phenotypes for Blood Group, Dombrock System

Clinical features from OMIM:

616060

Drugs & Therapeutics for Blood Group, Dombrock System

Search Clinical Trials , NIH Clinical Center for Blood Group, Dombrock System

Genetic Tests for Blood Group, Dombrock System

Anatomical Context for Blood Group, Dombrock System

MalaCards organs/tissues related to Blood Group, Dombrock System:

42
Heart, Kidney, Liver, Bone, Breast, Brain, Lung

Publications for Blood Group, Dombrock System

Articles related to Blood Group, Dombrock System:

(show top 50) (show all 86)
# Title Authors Year
1
'The right thing to do': Fostering social inclusion for mental health service users through acts of citizenship. ( 30152193 )
2019
2
Pakistan Developmental Origins of Health and Disease (DOHaD) Society: addressing the 'DO' component of DOHaD. ( 30994086 )
2019
3
'The way we do the things we do' - decision making transparency at the Journal of Child Psychology and Psychiatry. ( 29235651 )
2018
4
Integrity situational judgement test for medical school selection: judging 'what to do' versus 'what not to do'. ( 29349804 )
2018
5
Next on your 'to do' list Mr Gove …. ( 29654073 )
2018
6
Low-value clinical practices and harm caused by non-adherence to 'do not do' recommendations in primary care in Spain: a Delphi study. ( 30252074 )
2018
7
'Everything I enjoy doing I just couldn't do': Biographical disruption for sport-related injury. ( 30253661 )
2018
8
How to 'do' CPD with your team (from the organisation's perspective). ( 28603393 )
2017
9
Suitable support for anxious hospice patients: what do nurses 'know', 'do' and 'need'? An explanatory mixed method study. ( 28667086 )
2017
10
'Keep the patient at the centre of everything you do'. ( 28857008 )
2017
11
New horizons in the implementation and research of comprehensive geriatric assessment: knowing, doing and the 'know-do' gap. ( 26941353 )
2016
12
Radiotherapy for Prostate Cancer: is it 'what you do' or 'the way that you do it'? A UK Perspective on Technique and Quality Assurance. ( 27425582 )
2016
13
Ian Brack: 'We are going to get better at what we do'. ( 27608565 )
2016
14
A fresh look at Miller's pyramid: assessment at the 'Is' and 'Do' levels. ( 27873421 )
2016
15
Florida county health department, environmental health 2006 survey: do rural counties know "what to do' in a chemical or all-hazards event? ( 25619031 )
2015
16
Beyond Mannheim: Conceptualising how people 'talk' and 'do' generations in contemporary society. ( 26047985 )
2015
17
Hire Your Spouse? What to Consider Before You Say 'I Do'. ( 26285529 )
2015
18
While Gay Couples Say 'I Do', Health Care Often Says 'We Don't'. ( 26401541 )
2015
19
Empowered to do 'what I want to do' despite diabetic ESRD. ( 26454908 )
2015
20
'We don't tell people what to do': ethical practice and Indigenous health promotion. ( 26599355 )
2015
21
'He is the one who is providing you with everything so whatever he says is what you do': A Qualitative Study on Factors Affecting Secondary Schoolgirls' Dropout in Rural Western Kenya. ( 26636771 )
2015
22
'It's nice to have something to do': early-onset dementia and maintaining purposeful activity. ( 24841949 )
2014
23
Upper cervical instability associated with rheumatoid arthritis: what to 'know' and what to 'do'. ( 23414961 )
2013
24
A 'can-do' attitude. ( 23763104 )
2013
25
Strengthening government tobacco control in low- and middle-income countries: a 'must do' for lung health progress. ( 23827023 )
2013
26
'I am now doing things that I did not think I would be able to do'. ( 23965113 )
2013
27
'How to know what you need to do': a cross-country comparison of maternal health guidelines in Burkina Faso, Ghana and Tanzania. ( 22500744 )
2012
28
'We have been able to raise the profile of what nurses do'. ( 28091297 )
2012
29
A 'can do' attitude. ( 21702352 )
2011
30
Feeling pinched. Hospitals, docs anxious as 'provider payment cuts are pretty easy to do'. ( 21882387 )
2011
31
'Do as say, but not as I do': are next generation nurses role models for health? ( 21999028 )
2011
32
'My mother-in-law tells me what to do'. ( 24893485 )
2011
33
Collider gets yet more exotic 'to-do' list. ( 20651667 )
2010
34
The Dombrock blood group system: a review. ( 20932078 )
2010
35
Absence of DOMR, a new antigen in the Dombrock blood group system that weakens expression of Do(b) , Gy(a) , Hy, Jo(a) , and DOYA antigens. ( 20412531 )
2010
36
New antigen in the Dombrock blood group system, DOYA, ablates expression of Do(a) and weakens expression of Hy, Jo(a), and Gy(a) antigens. ( 20088839 )
2010
37
Astronomy. Beset by delays, U.S. astronomers ponder a better 'to do' list. ( 19179506 )
2009
38
From 'the thing to do' to 'defying the ravages of age': older women reflect on the use of lipstick. ( 20183145 )
2009
39
'Staffing levels dictate what i do'. ( 28080702 )
2009
40
'I don't do like I used to do': a grounded theory approach to conceptualising awareness in people with moderate to severe dementia living in long-term care. ( 18325650 )
2008
41
'Improvements have been made, but there is still a lot to do'. Interview by Tamsin Snow. ( 18540552 )
2008
42
Basophils: what they 'can do' versus what they 'actually do'. ( 19008933 )
2008
43
Focus on the 'can do'. Interview by Charlie Callanan. ( 19093351 )
2008
44
Trustees of the Year 2007. 'The right thing to do'. Moffitt helps lead fight over integrity of disclosures. ( 17432259 )
2007
45
'Breaking up is hard to do': perspectives of general practitioners and patients towards removals from GP lists. ( 17659430 )
2007
46
'It's just the normal thing to do': exploring parental decision-making about the 'five-in-one' vaccine. ( 17850931 )
2007
47
'To do or not to do'? The neurobiology of decision-making in daily life: I. Getting the basics. ( 29213362 )
2007
48
What to do when 'there is nothing more to do'? A study within a salutogenic framework of family members' experience of palliative home care staff. ( 17106866 )
2007
49
Why 'making do' just will not do. ( 16875276 )
2006
50
'Right' way to 'do' illness? Thinking critically about positive thinking. ( 16958645 )
2006

Variations for Blood Group, Dombrock System

ClinVar genetic disease variations for Blood Group, Dombrock System:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ART4 NM_021071.3(ART4): c.793G> A (p.Asp265Asn) single nucleotide variant Affects rs11276 GRCh37 Chromosome 12, 14993439: 14993439
2 ART4 NM_021071.3(ART4): c.793G> A (p.Asp265Asn) single nucleotide variant Affects rs11276 GRCh38 Chromosome 12, 14840505: 14840505
3 ART4 NM_021071.3(ART4): c.145-2A> G single nucleotide variant Affects rs587777831 GRCh37 Chromosome 12, 14994089: 14994089
4 ART4 NM_021071.3(ART4): c.145-2A> G single nucleotide variant Affects rs587777831 GRCh38 Chromosome 12, 14841155: 14841155
5 ART4 NM_021071.3(ART4): c.343_350del (p.Met115Hisfs) deletion Affects rs587777832 GRCh38 Chromosome 12, 14840948: 14840955
6 ART4 NM_021071.3(ART4): c.343_350del (p.Met115Hisfs) deletion Affects rs587777832 GRCh37 Chromosome 12, 14993882: 14993889
7 ART4 NM_021071.3(ART4): c.144+2T> C single nucleotide variant Affects rs587777833 GRCh37 Chromosome 12, 14995902: 14995902
8 ART4 NM_021071.3(ART4): c.144+2T> C single nucleotide variant Affects rs587777833 GRCh38 Chromosome 12, 14842968: 14842968
9 ART4 NM_021071.3(ART4): c.442C> T (p.Gln148Ter) single nucleotide variant Affects rs56340844 GRCh37 Chromosome 12, 14993790: 14993790
10 ART4 NM_021071.3(ART4): c.442C> T (p.Gln148Ter) single nucleotide variant Affects rs56340844 GRCh38 Chromosome 12, 14840856: 14840856

Expression for Blood Group, Dombrock System

Search GEO for disease gene expression data for Blood Group, Dombrock System.

Pathways for Blood Group, Dombrock System

GO Terms for Blood Group, Dombrock System

Sources for Blood Group, Dombrock System

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70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
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75 UMLS via Orphanet
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