GE
MCID: BLD164
MIFTS: 31

Blood Group, Gerbich System (GE)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Gerbich System

MalaCards integrated aliases for Blood Group, Gerbich System:

Name: Blood Group, Gerbich System 58 30 6
Gerbich Blood Group System 58
Ges 77
Ge 58

Classifications:



External Ids:

OMIM 58 616089
MedGen 43 C1292300
SNOMED-CT via HPO 70 178935009 191169008 250242004

Summaries for Blood Group, Gerbich System

OMIM : 58 The Gerbich blood group system contains 6 high-prevalence and 5 low-prevalence antigens that are expressed on glycophorin C (GPC), glycophorin D (GPD), or both GPC and GPD. GPC and GPD, which contribute stability to the red blood cell membrane, are encoded by the same gene, GYPC, through the use of alternative translational start sites. Deficiency of GPC and GPD is associated with hereditary elliptocytosis, and Gerbich antigens act as receptors for the malarial parasite Plasmodium falciparum (see 611162). The Gerbich antibodies anti-Ge2 and anti-Ge3 have caused hemolytic transfusion reactions, and anti-Ge3 has produced hemolytic disease of the fetus and newborn (review by Walker and Reid, 2010). (616089)

MalaCards based summary : Blood Group, Gerbich System, also known as gerbich blood group system, is related to periventricular nodular heterotopia 8 and herpes simplex. An important gene associated with Blood Group, Gerbich System is GYPC (Glycophorin C (Gerbich Blood Group)). Affiliated tissues include bone, brain and lung, and related phenotypes are blood group antigen abnormality and elliptocytosis

Wikipedia : 77 The Crawford expedition was a campaign on the western front of the American Revolutionary War, and one... more...

Related Diseases for Blood Group, Gerbich System

Diseases related to Blood Group, Gerbich System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 periventricular nodular heterotopia 8 11.2
2 herpes simplex 10.6
3 retinoblastoma 10.4
4 chickenpox 10.3
5 streptococcal group a invasive disease 10.2
6 malaria 10.1
7 plague 10.1
8 neutrophil migration 10.1
9 rheumatoid arthritis 10.1
10 anemia, autoimmune hemolytic 10.1
11 arthritis 10.1
12 hemolytic anemia 10.1
13 degos 'en cocarde' erythrokeratoderma 10.1
14 isolated optic neuritis 10.1
15 blood group, colton system 10.0
16 breast cancer 10.0
17 tetralogy of fallot 10.0
18 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.0
19 disorganization, mouse, homolog of 10.0
20 retinitis pigmentosa 10.0
21 horns in sheep 10.0
22 intraocular pressure quantitative trait locus 10.0
23 porphyria, acute hepatic 10.0
24 pulmonary hypertension, primary, 2 10.0
25 systemic scleroderma 10.0
26 laryngotracheitis 10.0
27 patulous eustachian tube 10.0
28 melanoma 10.0
29 adenocarcinoma 10.0
30 rapidly involuting congenital hemangioma 10.0
31 radin blood group antigen 9.8
32 multiple sclerosis 9.8
33 suppressor of tumorigenicity 3 9.8
34 lung cancer 9.8
35 glutaric aciduria iii 9.8
36 kuru 9.8
37 pancreatic cancer 9.8
38 melnick-needles syndrome 9.8
39 welander distal myopathy 9.8
40 body mass index quantitative trait locus 1 9.8
41 meningioma, familial 9.8
42 anxiety 9.8
43 granulomatosis with polyangiitis 9.8
44 gastric cancer 9.8
45 leptin deficiency or dysfunction 9.8
46 blood group, vel system 9.8
47 nevus comedonicus 9.8
48 diabetes mellitus 9.8
49 leukemia 9.8
50 lymphoma 9.8

Graphical network of the top 20 diseases related to Blood Group, Gerbich System:



Diseases related to Blood Group, Gerbich System

Symptoms & Phenotypes for Blood Group, Gerbich System

Human phenotypes related to Blood Group, Gerbich System:

33
# Description HPO Frequency HPO Source Accession
1 blood group antigen abnormality 33 HP:0010970
2 elliptocytosis 33 HP:0004445

Clinical features from OMIM:

616089

Drugs & Therapeutics for Blood Group, Gerbich System

Search Clinical Trials , NIH Clinical Center for Blood Group, Gerbich System

Genetic Tests for Blood Group, Gerbich System

Genetic tests related to Blood Group, Gerbich System:

# Genetic test Affiliating Genes
1 Blood Group, Gerbich System 30 GYPC

Anatomical Context for Blood Group, Gerbich System

MalaCards organs/tissues related to Blood Group, Gerbich System:

42
Bone, Brain, Lung, Breast, Testes, Skin, Liver

Publications for Blood Group, Gerbich System

Articles related to Blood Group, Gerbich System:

(show top 50) (show all 3013)
# Title Authors Year
1
Comparison of 18F-GE-180 and dynamic 18F-FET PET in high grade glioma: a double-tracer pilot study. ( 30244386 )
2019
2
Molecular analyses and phylogeny of the herpes simplex virus 2 US9 and glycoproteins gE/gI obtained from infected subjects during the Herpevac Trial for Women. ( 30849089 )
2019
3
Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [18F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter. ( 30796709 )
2019
4
Triple bonds between iron and heavier group-14 elements in the AFe(CO)3- complexes (A = Ge, Sn, and Pb). ( 31020278 )
2019
5
Effects of Au and Ge Additions on the Microstructures and Properties of Ag-1.5Cu-0.1Y Alloys. ( 30609702 )
2019
6
Realization of the Kohn's Theorem in Ge/Si Quantum Dots with Hole Gas: Theory and Experiment. ( 30609851 )
2019
7
High mobility Ge pMOSFETs with amorphous Si passivation: impact of surface orientation. ( 30623254 )
2019
8
Gate Tunable Hole Charge Qubit Formed in a Ge/Si Nanowire Double Quantum Dot Coupled to Microwave Photons. ( 30636426 )
2019
9
Synthesis, Structure, Thermal Behavior and cis/trans Isomerization of 2,2'-(EMe₃)₂ (E = C, Si, Ge, Sn) Substituted Azobenzenes. ( 30650637 )
2019
10
Dual Geometry Schemes in Tetrel Bonds: Complexes between TF₄ (T = Si, Ge, Sn) and Pyridine Derivatives. ( 30669688 )
2019
11
High On-Current Ge-Channel Heterojunction Tunnel Field-Effect Transistor Using Direct Band-to-Band Tunneling. ( 30678322 )
2019
12
Structural, energetic, and vibrational properties of the homodimers of the silyl, germyl, and stannyl halides, (MH3X)2 (M = Si, Ge, Sn; X = F, Cl, Br, I). ( 30680467 )
2019
13
Anisotropic 2D metallicity: plasmons in Ge(1 0 0)-Au. ( 30695765 )
2019
14
Highly tunable doping in Ge quantum dots/graphene composite with distinct quantum dot growth evolution. ( 30695771 )
2019
15
Recovery Performance of Ge-Doped Vertical GaN Schottky Barrier Diodes. ( 30706287 )
2019
16
Electron-phonon dynamics in 2D carbon based-hybrids XC (X  =  Si, Ge, Sn). ( 30726191 )
2019
17
Temperature-Dependent Li Storage Performance in Nanoporous Cu-Ge-Al Alloy. ( 30741522 )
2019
18
Role of grain boundaries in Ge-Sb-Te based chalcogenide superlattices. ( 30769332 )
2019
19
Hexacoordinated Tetrel-Bonded Complexes between TF₄ (T = Si, Ge, Sn, Pb) and NCH. Competition between σ and π-Holes. ( 30770634 )
2019
20
Ge(ii) cation catalyzed hydroboration of aldehydes and ketones. ( 30816383 )
2019
21
Directed Gas Phase Formation of the Germaniumsilylene Butterfly Molecule (Ge(μ-H2)Si). ( 30817157 )
2019
22
Alignment of semiconducting graphene nanoribbons on vicinal Ge(001). ( 30821309 )
2019
23
Mechanistic Dichotomy of Magnesium- and Zinc-Based Germanium Nucleophiles in the C(sp3 )-Ge Cross-Coupling with Alkyl Electrophiles. ( 30839143 )
2019
24
Evaluation of ge-doped silica fibre TLDs for <i>in vivo</i> dosimetry during intraoperative radiotherapy. ( 30840946 )
2019
25
Theoretical Investigation on the Microscopic Mechanism of Lattice Thermal Conductivity of ZnXP2 (X = Si, Ge, and Sn). ( 30848900 )
2019
26
Electron collisions with X(CH3)4 molecules (X = C, Si, Ge). ( 30849877 )
2019
27
Equilibrium Coordination of NHCs to Si(IV) Species and Donor Exchange in Donor-Acceptor Stabilized Si(II) and Ge(II) Compounds. ( 30860359 )
2019
28
First-Principles Study on Structural, Electronic, and Optical Properties of Inorganic Ge-Based Halide Perovskites. ( 30864433 )
2019
29
Single and double hole quantum dots in strained Ge/SiGe quantum wells. ( 30869078 )
2019
30
A New Family of Two-Dimensional Crystals: Open-Framework T3X (T=C, Si, Ge, Sn; X=O, S, Se, Te) Compounds with Tetrahedral Bonding. ( 30875471 )
2019
31
Comparative study of NIR-MIR beamsplitters based on ZnS/YbF3 and Ge/YbF3. ( 30876155 )
2019
32
High-speed photo detection at two-micron-wavelength: technology enablement by GeSn/Ge multiple-quantum-well photodiode on 300 mm Si substrate. ( 30876175 )
2019
33
High-efficiency Ge thermo-optic phase shifter on Ge-on-insulator platform. ( 30876230 )
2019
34
Facile Synthesis of Amorphous Ge Supported by Ni Nanopyramid Arrays as an Anode Material for Sodium-Ion Batteries. ( 30886787 )
2019
35
Preliminary Study of Ge-DLC Nanocomposite Biomaterials Prepared by Laser Codeposition. ( 30889797 )
2019
36
Physical properties of Si-Ge alloys in C2/m phase: a comprehensive investigation. ( 30893672 )
2019
37
Synthesis and thermal characterization of novel phase change materials (PCMs) of the Se-Te-Sn-Ge (STSG) multi-component system: calorimetric studies of the glass/crystal phase transition. ( 30900720 )
2019
38
Growth of heterojunctions in Si-Ge alloy nanowires by altering AuGeSi eutectic composition using an approach based on thermal oxidation. ( 30913543 )
2019
39
Comparison of the Physical and Electrical Properties of HfO₂/Al₂O₃/HfO₂/GeOx/Ge and HfO₂/Al₂O₃/GeOx/Ge Gate Stacks. ( 30913744 )
2019
40
Characterization of GE discovery IGS 740 angiography system by means of channelized Hotelling observer (CHO). ( 30921779 )
2019
41
Influence of Structure on Electronic Charge Transport in 3D Ge Nanowire Networks in an Alumina Matrix. ( 30932001 )
2019
42
Realization of High Thermoelectric Figure of Merit in Solution Synthesized 2D SnSe Nanoplates via Ge Alloying. ( 30946576 )
2019
43
Ge pMOSFETs with GeOx Passivation Formed by Ozone and Plasma Post Oxidation. ( 30953229 )
2019
44
The Novel of n-p-n Type Transition in the ZnSe/Ge Heterojunction Nanowire: First Principles Study. ( 30961748 )
2019
45
A Cross-Calibration Study of GE Lunar iDXA and GE Lunar DPX Pro for Body Composition Measurements in Children and Adults. ( 30981615 )
2019
46
Microscopic Views of Atomic and Molecular Oxygen Bonding with epi Ge(001)-2 × 1 Studied by High-Resolution Synchrotron Radiation Photoemission. ( 30987390 )
2019
47
A2SrMIVS4 (A = Li, Na; MIV = Ge, Sn) concurrently exhibiting wide bandgaps and good nonlinear optical responses as new potential infrared nonlinear optical materials. ( 31015936 )
2019
48
Self-ordering of chemisorbed PTCDA molecules on Ge(001) driven by repulsive forces. ( 31017146 )
2019
49
Dosimetric response of fabricated Ge-doped optical fibres in computed tomography RQT beam quality X-ray beams. ( 31018196 )
2019
50
Preparation of non-oxidized Ge quantum dot lattices in amorphous Al<sub>2</sub>O<sub>3</sub>, Si<sub>3</sub>N<sub>4</sub> and SiC matrices. ( 31026849 )
2019

Variations for Blood Group, Gerbich System

ClinVar genetic disease variations for Blood Group, Gerbich System:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GYPC NM_002101.4(GYPC): c.50_106del57 (p.Ala23_Met41del) deletion Affects rs1553469573 GRCh38 Chromosome 2, 126690255: 126690311
2 GYPC NM_002101.4(GYPC): c.50_106del57 (p.Ala23_Met41del) deletion Affects rs1553469573 GRCh37 Chromosome 2, 127447831: 127447887
3 GYPC NM_002101.4(GYPC): c.23A> G (p.Asn8Ser) single nucleotide variant Affects rs121912760 GRCh37 Chromosome 2, 127413862: 127413862
4 GYPC NM_002101.4(GYPC): c.23A> G (p.Asn8Ser) single nucleotide variant Affects rs121912760 GRCh38 Chromosome 2, 126656286: 126656286
5 GYPC NM_002101.4(GYPC): c.40C> T (p.Leu14Phe) single nucleotide variant Affects rs121912761 GRCh37 Chromosome 2, 127413879: 127413879
6 GYPC NM_002101.4(GYPC): c.40C> T (p.Leu14Phe) single nucleotide variant Affects rs121912761 GRCh38 Chromosome 2, 126656303: 126656303

Expression for Blood Group, Gerbich System

Search GEO for disease gene expression data for Blood Group, Gerbich System.

Pathways for Blood Group, Gerbich System

GO Terms for Blood Group, Gerbich System

Sources for Blood Group, Gerbich System

3 CDC
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10 dbSNP
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58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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