MCID: BLD052
MIFTS: 31

Blood Group Incompatibility

Categories: Blood diseases

Aliases & Classifications for Blood Group Incompatibility

MalaCards integrated aliases for Blood Group Incompatibility:

Name: Blood Group Incompatibility 12 54 44 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4176
MeSH 44 D001787
UMLS 70 C0005806

Summaries for Blood Group Incompatibility

MalaCards based summary : Blood Group Incompatibility is related to neonatal jaundice and inherited metabolic disorder. An important gene associated with Blood Group Incompatibility is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways are Glucose / Energy Metabolism and Biosynthesis of cofactors. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, placenta and myeloid.

Related Diseases for Blood Group Incompatibility

Diseases related to Blood Group Incompatibility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 neonatal jaundice 30.2 UGT1A1 G6PD
2 inherited metabolic disorder 29.7 UGT1A8 UGT1A1 ALB
3 fetal erythroblastosis 29.6 RHD RHCE KEL ALB
4 bilirubin metabolic disorder 29.4 UGT1A8 UGT1A1 RHD RHCE PKM G6PD
5 hemolytic anemia 29.1 UGT1A1 SLC4A1 RHD RHCE PKM G6PD
6 glucosephosphate dehydrogenase deficiency 29.1 UGT1A8 UGT1A1 SLC4A1 G6PD FYB1 ALB
7 kernicterus 28.8 UGT1A8 UGT1A1 SLC4A1 RHD RHCE PKM
8 graft-versus-host disease 10.4
9 infertility 10.3
10 acute graft versus host disease 10.2
11 primary thrombocytopenia 10.2 RHD RHCE
12 patau syndrome 10.2 RHD RHCE
13 epicardium cancer 10.1 UGT1A8 UGT1A1
14 pure red-cell aplasia 10.1
15 acute bilirubin encephalopathy 10.1
16 anemia, autoimmune hemolytic 10.1 RHCE G6PD
17 glutamate-cysteine ligase deficiency 10.1 SLC4A1 RHD RHCE
18 thiopurines, poor metabolism of, 1 10.1 UGT1A8 UGT1A1
19 parotitis 10.1 G6PD ALB
20 cardiomyopathy, dilated, with hypergonadotropic hypogonadism 10.1 UGT1A8 UGT1A1
21 congenital nonspherocytic hemolytic anemia 10.0 PKM G6PD
22 pyruvate kinase deficiency of red cells 10.0 PKM G6PD
23 bilirubin, serum level of, quantitative trait locus 1 10.0 UGT1A8 UGT1A1
24 sickle cell disease 10.0 UGT1A1 RHD G6PD
25 dihydropyrimidine dehydrogenase deficiency 10.0 UGT1A8 UGT1A1
26 neonatal anemia 10.0 RHD RHCE KEL
27 choledocholithiasis 10.0 UGT1A1 ALB
28 hereditary elliptocytosis 10.0 SLC4A1 RHD RHCE G6PD
29 drug-induced hepatitis 10.0 UGT1A1 ALB
30 multiple sclerosis 10.0
31 hydrops fetalis, nonimmune 10.0
32 leukemia, acute myeloid 10.0
33 aplastic anemia 10.0
34 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
35 myelodysplastic syndrome 10.0
36 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.0
37 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
38 lymphatic malformation 7 10.0
39 hepatic veno-occlusive disease 10.0
40 sensorineural hearing loss 10.0
41 pre-eclampsia 10.0
42 disseminated intravascular coagulation 10.0
43 acute leukemia 10.0
44 obstructive jaundice 10.0
45 kidney cortex necrosis 10.0
46 placenta disease 10.0
47 myeloid leukemia 10.0
48 splenomegaly 10.0
49 acute liver failure 10.0
50 rh deficiency syndrome 10.0 RHD RHCE RHBG

Graphical network of the top 20 diseases related to Blood Group Incompatibility:



Diseases related to Blood Group Incompatibility

Symptoms & Phenotypes for Blood Group Incompatibility

Drugs & Therapeutics for Blood Group Incompatibility

Drugs for Blood Group Incompatibility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 1, Phase 2
2 Antibodies Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Single Center, Open-label Study to Determine the Safety and Efficacy of a Dosing Regimen of Eculizumab Added to Conventional Treatment in the Prevention of Antibody-mediated Rejection (AMR) in ABO Blood Group Incompatible Living Donor Kidney Transplantation (ABOi LDKTx) Terminated NCT01095887 Phase 1, Phase 2 Eculizumab

Search NIH Clinical Center for Blood Group Incompatibility

Cochrane evidence based reviews: blood group incompatibility

Genetic Tests for Blood Group Incompatibility

Anatomical Context for Blood Group Incompatibility

MalaCards organs/tissues related to Blood Group Incompatibility:

40
Bone Marrow, Placenta, Myeloid, Kidney, Endothelial, Bone, Whole Blood

Publications for Blood Group Incompatibility

Articles related to Blood Group Incompatibility:

(show top 50) (show all 361)
# Title Authors PMID Year
1
Genetic polymorphisms in Thai neonates with hyperbilirubinemia. 61 54
19397531 2009
2
Combination of ABO blood group incompatibility and glucose-6-phosphate dehydrogenase deficiency: effect on hemolysis and neonatal hyperbilirubinemia. 54 61
9628306 1998
3
A single-center experience on exchange transfusion therapy in 123 full-term cases of severe neonatal hyperbilirubinemia in Wuhan. 61
33225794 2021
4
Tailored immunosuppression after kidney transplantation - a single center real-life experience. 61
33228545 2020
5
Immunosuppression management in renal transplant recipients with normal-immunological risk: 10-year results from the Swiss Transplant Cohort Study. 61
33277913 2020
6
Etiology and therapeutic management of neonatal jaundice in Iran: a systematic review and meta-analysis. 61
32052364 2020
7
Preventive Effects of Probiotic Supplementation on Neonatal Hyperbilirubinemia Caused by Isoimmunization. 61
31242512 2020
8
Soybean-Oil Lipid Minimization for Prevention of Intestinal Failure-Associated Liver Disease in Late-Preterm and Term Infants With Gastrointestinal Surgical Disorders. 61
32854150 2020
9
Why Living Kidney Donor Candidates Are Turned Down? A Single-Center Cohort Study. 61
32963917 2020
10
Alternative donor: αß/CD19 T-cell-depleted haploidentical hematopoietic stem cell transplantation for sickle cell disease. 61
32202248 2020
11
Minor blood group incompatibility due to blood groups other than Rh(D) leading to hemolytic disease of fetus and newborn: a need for routine antibody screening during pregnancy. 61
32201675 2020
12
Impact of ABO blood group incompatibility on the outcomes of allogeneic hematopoietic stem cell transplantation. 61
31311753 2020
13
Next Generation Sequencing-Based Fetal ABO Blood Group Prediction by Analysis of Cell-Free DNA from Maternal Plasma. 61
32110193 2020
14
Noninvasive Fetal RhD Blood Group Genotyping: A Health Technology Assessment. 61
33240456 2020
15
Hemolytic Anemia Due To Anti-c Incompatibility in The Newborn Period: A Case Report. 61
33364894 2020
16
The First North American Experience Using Glycosorb Immunoadsorption Columns for Blood Group-Incompatible Kidney Transplantation. 61
33101699 2020
17
Noninvasive Detection of Hemolysis with ETCOc Measurement in Neonates at Risk for Significant Hyperbilirubinemia. 61
32894848 2020
18
Red blood cell transfusion burden by day 30 predicts mortality in adults after single-unit cord blood transplantation. 61
31089286 2019
19
Platelet transfusion thresholds in neonatal medicine. 61
31488313 2019
20
Therapeutic apheresis in kidney transplantation: An updated review. 61
31750088 2019
21
Perinatal risk factors for type 1 diabetes revisited: a population-based register study. 61
31041471 2019
22
Severe Fetal Hemolysis and Cholestasis Due to High-Titer Maternal IgG Anti-A Antibodies. 61
30872329 2019
23
[Pediatric kidney transplantation: early and long-term outcomes following 1187 procedures]. 61
30789603 2019
24
Assessing the impact of ABO incompatibility on major allogeneic hematopoietic stem cell transplant outcomes: a prospective, single-center, cohort study. 61
30793098 2019
25
[Graft failure in allogeneic hematopoietic stem cell trans-plantation]. 61
30900845 2018
26
Kidney exchange transplantation current status, an update and future perspectives. 61
29988896 2018
27
Similar Microvascular Inflammation and Tubulointerstitial Injury in ABO-Incompatible and Matched ABO-Compatible Kidney Allografts. 61
29880350 2018
28
[Clinical analysis of seven cases of rare hemolytic disease of the newborn]. 61
29783824 2018
29
Allele-selective RUNX1 binding regulates P1 blood group status by transcriptional control of A4GALT. 61
29438961 2018
30
Transfusion policy in allogeneic hematopoietic stem cell transplantation. 61
29724631 2018
31
ABO-incompatible kidney transplantation as a renal replacement therapy-A single low-volume center experience in Japan. 61
30596663 2018
32
Umbilical cord blood bilirubins, gestational age, and maternal race predict neonatal hyperbilirubinemia. 61
29856776 2018
33
Insights in Transplanting Complex Pediatric Renal Recipients With Vascular Anomalies. 61
28099405 2017
34
Hyperbilirubinemia due to minor blood group (anti-E) incompatibility in a newborn: a case report. 61
29062250 2017
35
A model of acute renal allograft rejection in outbred Yorkshire piglets. 61
28495618 2017
36
Baseline Anti-blood Group Antibody Titers and their Response to Desensitization and Kidney Transplantation. 61
28553039 2017
37
Past, present and future of kidney paired donation transplantation in India. 61
28507916 2017
38
ABO blood group incompatibility and infertility: still an open debate. 61
28104243 2017
39
Blood group incompatibility as risk of corneal rejection 61
29799709 2017
40
Oral administration of Chinese herbal medicine during gestation period for preventing hemolytic disease of the newborn due to ABO incompatibility: A systematic review of randomized controlled trials. 61
28719639 2017
41
Hemolytic Anemia and Heart Failure Caused by Anti-C and Anti-E Immunization. 61
27353998 2016
42
Carboxyhemoglobin levels as a predictor of risk for significant hyperbilirubinemia in African-American DAT(+) infants. 61
26765551 2016
43
ABO blood group incompatibility as an adverse risk factor for outcomes in patients with myelodysplastic syndromes and acute myeloid leukemia undergoing HLA-matched peripheral blood hematopoietic cell transplantation after reduced-intensity conditioning. 61
26446051 2016
44
Prospective Surveillance of Extreme Neonatal Hyperbilirubinemia in Australia. 61
26477873 2016
45
ABO-incompatible living donor kidney transplantation without post-transplant therapeutic plasma exchange. 61
25739580 2015
46
[New strategies in living donor kidney transplantation – blood group incompatible and crossover transplantation]. 61
26227981 2015
47
Modern approaches to incompatible kidney transplantation. 61
26167458 2015
48
Prenatal Training Improves New Mothers' Understanding of Jaundice. 61
26056164 2015
49
Experience of Exchange Transfusion in a Newly Established SCANU at a Tertiary Care Hospital in Bangladesh. 61
26007247 2015
50
[Hereditary spherocytosis. Review. Part II. Symptomatology, outcome, complications, and treatment]. 61
25727830 2015

Variations for Blood Group Incompatibility

Expression for Blood Group Incompatibility

Search GEO for disease gene expression data for Blood Group Incompatibility.

Pathways for Blood Group Incompatibility

Pathways related to Blood Group Incompatibility according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 UGT1A8 UGT1A1 PKM G6PD
2
Show member pathways
11.35 UGT1A8 UGT1A1 PKM
3
Show member pathways
10.69 UGT1A8 UGT1A1

GO Terms for Blood Group Incompatibility

Biological processes related to Blood Group Incompatibility according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 animal organ regeneration GO:0031100 9.49 UGT1A1 PKM
2 drug metabolic process GO:0017144 9.48 UGT1A8 UGT1A1
3 retinoic acid metabolic process GO:0042573 9.46 UGT1A8 UGT1A1
4 cellular glucuronidation GO:0052695 9.43 UGT1A8 UGT1A1
5 xenobiotic glucuronidation GO:0052697 9.4 UGT1A8 UGT1A1
6 flavonoid glucuronidation GO:0052696 9.37 UGT1A8 UGT1A1
7 negative regulation of fatty acid metabolic process GO:0045922 9.32 UGT1A8 UGT1A1
8 flavone metabolic process GO:0051552 9.26 UGT1A8 UGT1A1
9 negative regulation of steroid metabolic process GO:0045939 9.16 UGT1A8 UGT1A1
10 ammonium transmembrane transport GO:0072488 9.13 RHD RHCE RHBG
11 ammonium transport GO:0015696 8.8 RHD RHCE RHBG

Molecular functions related to Blood Group Incompatibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring glycosyl groups GO:0016757 9.63 UGT1A8 UGT1A1 A4GALT
2 enzyme inhibitor activity GO:0004857 9.48 UGT1A8 UGT1A1
3 steroid binding GO:0005496 9.43 UGT1A8 UGT1A1
4 glucuronosyltransferase activity GO:0015020 9.4 UGT1A8 UGT1A1
5 fatty acid binding GO:0005504 9.37 UGT1A8 ALB
6 retinoic acid binding GO:0001972 9.32 UGT1A8 UGT1A1
7 UDP-glycosyltransferase activity GO:0008194 9.26 UGT1A8 UGT1A1
8 ankyrin binding GO:0030506 9.16 SLC4A1 RHBG
9 toxic substance binding GO:0015643 8.96 ALB A4GALT
10 ammonium transmembrane transporter activity GO:0008519 8.8 RHD RHCE RHBG

Sources for Blood Group Incompatibility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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