MCID: BLD052
MIFTS: 32

Blood Group Incompatibility

Categories: Blood diseases

Aliases & Classifications for Blood Group Incompatibility

MalaCards integrated aliases for Blood Group Incompatibility:

Name: Blood Group Incompatibility 12 54 43 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4176
MeSH 43 D001787
UMLS 71 C0005806

Summaries for Blood Group Incompatibility

MalaCards based summary : Blood Group Incompatibility is related to neonatal jaundice and glucosephosphate dehydrogenase deficiency. An important gene associated with Blood Group Incompatibility is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways are Glutathione metabolism and Globo Sphingolipid Metabolism. The drugs Adenosine and Vasodilator Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and bone marrow.

Related Diseases for Blood Group Incompatibility

Diseases related to Blood Group Incompatibility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 neonatal jaundice 29.9 RHD G6PD
2 glucosephosphate dehydrogenase deficiency 29.9 G6PD ABO
3 hemolytic anemia 29.6 SLC4A1 RHD RHCE G6PD
4 fetal erythroblastosis 29.3 RHD RHCE KEL ABO
5 kernicterus 29.1 SLC4A1 RHD RHCE PKM G6PD ABO
6 bilirubin metabolic disorder 10.4
7 graft-versus-host disease 10.4
8 acute graft versus host disease 10.2
9 infertility 10.2
10 pure red-cell aplasia 10.1
11 red cell aplasia 10.1
12 primary thrombocytopenia 10.1 RHD RHCE
13 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
14 end stage renal disease 10.0
15 acute bilirubin encephalopathy 10.0
16 plasmodium falciparum malaria 10.0 SLC4A1 G6PD ABO
17 hereditary spherocytosis 10.0 SLC4A1 RHD G6PD
18 anemia, autoimmune hemolytic 10.0 RHCE G6PD
19 beta-thalassemia 10.0 SLC4A1 RHD G6PD
20 retinohepatoendocrinologic syndrome 9.9 RHD RHCE RHBG
21 congenital nonspherocytic hemolytic anemia 9.9 PKM G6PD
22 pyruvate kinase deficiency of red cells 9.9 PKM G6PD
23 hydrops fetalis, nonimmune 9.9
24 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 9.9
25 leukemia, acute myeloid 9.9
26 aplastic anemia 9.9
27 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
28 myelodysplastic syndrome 9.9
29 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.9
30 deficiency anemia 9.9
31 polyomavirus-associated nephropathy 9.9
32 ectopic pregnancy 9.9
33 thrombosis 9.9
34 hepatic veno-occlusive disease 9.9
35 sensorineural hearing loss 9.9
36 pre-eclampsia 9.9
37 disseminated intravascular coagulation 9.9
38 acute leukemia 9.9
39 obstructive jaundice 9.9
40 kidney cortex necrosis 9.9
41 inherited metabolic disorder 9.9
42 placenta disease 9.9
43 myeloid leukemia 9.9
44 splenomegaly 9.9
45 acute liver failure 9.9
46 neonatal anemia 9.9 RHD RHCE KEL
47 hereditary elliptocytosis 9.8 SLC4A1 RHD G6PD ABO
48 pigmentation disease 9.8 PKM G6PD ABO
49 bladder sarcoma 9.7 GGT7 GGT6
50 glutathionuria 9.6 GGT7 GGT6

Graphical network of the top 20 diseases related to Blood Group Incompatibility:



Diseases related to Blood Group Incompatibility

Symptoms & Phenotypes for Blood Group Incompatibility

Drugs & Therapeutics for Blood Group Incompatibility

Drugs for Blood Group Incompatibility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adenosine Approved, Investigational 58-61-7 60961
2 Vasodilator Agents
3 Anti-Arrhythmia Agents
4 Analgesics
5 Neurotransmitter Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Research Network for Neonatal Diseases Induced by Tissular Fetomaternal Alloimmunization Completed NCT00199628
2 Human Leucocytic Antigen Typing and Mutation of Adenosine Triphosphate Sensitive Potassium Channel Gene in Diabetic Patients Diagnosed Under the Age of One Year. Not yet recruiting NCT03169413

Search NIH Clinical Center for Blood Group Incompatibility

Cochrane evidence based reviews: blood group incompatibility

Genetic Tests for Blood Group Incompatibility

Anatomical Context for Blood Group Incompatibility

MalaCards organs/tissues related to Blood Group Incompatibility:

40
Kidney, Bone, Bone Marrow, Liver, Testes, Heart, Placenta

Publications for Blood Group Incompatibility

Articles related to Blood Group Incompatibility:

(show top 50) (show all 354)
# Title Authors PMID Year
1
Genetic polymorphisms in Thai neonates with hyperbilirubinemia. 54 61
19397531 2009
2
Combination of ABO blood group incompatibility and glucose-6-phosphate dehydrogenase deficiency: effect on hemolysis and neonatal hyperbilirubinemia. 61 54
9628306 1998
3
Alternative donor: αß/CD19 T-cell-depleted haploidentical hematopoietic stem cell transplantation for sickle cell disease. 61
32202248 2020
4
High-Levels of 'Natural' ABO Antibodies are Produced in Female vs. Male Mice. 61
32465849 2020
5
Next Generation Sequencing-Based Fetal ABO Blood Group Prediction by Analysis of Cell-Free DNA from Maternal Plasma. 61
32110193 2020
6
Minor blood group incompatibility due to blood groups other than Rh(D) leading to hemolytic disease of fetus and newborn: a need for routine antibody screening during pregnancy. 61
32201675 2020
7
Etiology and therapeutic management of neonatal jaundice in Iran: a systematic review and meta-analysis. 61
32052364 2020
8
Impact of ABO blood group incompatibility on the outcomes of allogeneic hematopoietic stem cell transplantation. 61
31311753 2020
9
Platelet transfusion thresholds in neonatal medicine. 61
31488313 2019
10
Red blood cell transfusion burden by day 30 predicts mortality in adults after single-unit cord blood transplantation. 61
31089286 2019
11
Therapeutic apheresis in kidney transplantation: An updated review. 61
31750088 2019
12
Perinatal risk factors for type 1 diabetes revisited: a population-based register study. 61
31041471 2019
13
Preventive Effects of Probiotic Supplementation on Neonatal Hyperbilirubinemia Caused by Isoimmunization. 61
31242512 2019
14
Severe Fetal Hemolysis and Cholestasis Due to High-Titer Maternal IgG Anti-A Antibodies. 61
30872329 2019
15
Assessing the impact of ABO incompatibility on major allogeneic hematopoietic stem cell transplant outcomes: a prospective, single-center, cohort study. 61
30793098 2019
16
[Pediatric kidney transplantation: early and long-term outcomes following 1187 procedures]. 61
30789603 2019
17
[Graft failure in allogeneic hematopoietic stem cell trans-plantation]. 61
30900845 2018
18
Similar Microvascular Inflammation and Tubulointerstitial Injury in ABO-Incompatible and Matched ABO-Compatible Kidney Allografts. 61
29880350 2018
19
Kidney exchange transplantation current status, an update and future perspectives. 61
29988896 2018
20
[Clinical analysis of seven cases of rare hemolytic disease of the newborn]. 61
29783824 2018
21
Transfusion policy in allogeneic hematopoietic stem cell transplantation. 61
29724631 2018
22
Allele-selective RUNX1 binding regulates P1 blood group status by transcriptional control of A4GALT. 61
29438961 2018
23
ABO-incompatible kidney transplantation as a renal replacement therapy-A single low-volume center experience in Japan. 61
30596663 2018
24
Umbilical cord blood bilirubins, gestational age, and maternal race predict neonatal hyperbilirubinemia. 61
29856776 2018
25
Insights in Transplanting Complex Pediatric Renal Recipients With Vascular Anomalies. 61
28099405 2017
26
Hyperbilirubinemia due to minor blood group (anti-E) incompatibility in a newborn: a case report. 61
29062250 2017
27
A model of acute renal allograft rejection in outbred Yorkshire piglets. 61
28495618 2017
28
Baseline Anti-blood Group Antibody Titers and their Response to Desensitization and Kidney Transplantation. 61
28553039 2017
29
Past, present and future of kidney paired donation transplantation in India. 61
28507916 2017
30
ABO blood group incompatibility and infertility: still an open debate. 61
28104243 2017
31
Blood group incompatibility as risk of corneal rejection 61
29799709 2017
32
Oral administration of Chinese herbal medicine during gestation period for preventing hemolytic disease of the newborn due to ABO incompatibility: A systematic review of randomized controlled trials. 61
28719639 2017
33
Hemolytic Anemia and Heart Failure Caused by Anti-C and Anti-E Immunization. 61
27353998 2016
34
Carboxyhemoglobin levels as a predictor of risk for significant hyperbilirubinemia in African-American DAT(+) infants. 61
26765551 2016
35
ABO blood group incompatibility as an adverse risk factor for outcomes in patients with myelodysplastic syndromes and acute myeloid leukemia undergoing HLA-matched peripheral blood hematopoietic cell transplantation after reduced-intensity conditioning. 61
26446051 2016
36
Prospective Surveillance of Extreme Neonatal Hyperbilirubinemia in Australia. 61
26477873 2016
37
ABO-incompatible living donor kidney transplantation without post-transplant therapeutic plasma exchange. 61
25739580 2015
38
[New strategies in living donor kidney transplantation – blood group incompatible and crossover transplantation]. 61
26227981 2015
39
Modern approaches to incompatible kidney transplantation. 61
26167458 2015
40
Prenatal Training Improves New Mothers' Understanding of Jaundice. 61
26056164 2015
41
Experience of Exchange Transfusion in a Newly Established SCANU at a Tertiary Care Hospital in Bangladesh. 61
26007247 2015
42
[Hereditary spherocytosis. Review. Part II. Symptomatology, outcome, complications, and treatment]. 61
25727830 2015
43
Four years of experience with the Australian kidney paired donation programme. 61
25408125 2015
44
A complete treatment of adult living donor liver transplantation: a review of surgical technique and current challenges to expand indication of patients. 61
25358749 2015
45
A Case of Hemolytic Disease of the Newborn due to Di (a) Antibody. 61
26682081 2015
46
Estimating the Risk of ABO Hemolytic Disease of the Newborn in Lagos. 61
26491605 2015
47
Predictive value of cord blood bilirubin for hyperbilirubinemia in neonates at risk for maternal-fetal blood group incompatibility and hemolytic disease of the newborn. 61
26518407 2015
48
[Kernicterus is preventable but still occurs]. 61
25944067 2015
49
Blood transfusion and the World Wars. 61
25819015 2015
50
Variable Clinical Presentations of ABO Incompatibility in Dizygotic Twins. 61
26803011 2015

Variations for Blood Group Incompatibility

Expression for Blood Group Incompatibility

Search GEO for disease gene expression data for Blood Group Incompatibility.

Pathways for Blood Group Incompatibility

GO Terms for Blood Group Incompatibility

Cellular components related to Blood Group Incompatibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.28 SLC4A1 RHD RHCE RHBG KEL GGT7
2 cytoplasmic side of plasma membrane GO:0009898 8.96 SLC4A1 G6PD

Biological processes related to Blood Group Incompatibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione metabolic process GO:0006749 9.33 GGT7 GGT6 G6PD
2 glutathione biosynthetic process GO:0006750 9.32 GGT7 GGT6
3 leukotriene D4 biosynthetic process GO:1901750 9.26 GGT7 GGT6
4 ammonium transmembrane transport GO:0072488 9.13 RHD RHCE RHBG
5 ammonium transport GO:0015696 8.8 RHD RHCE RHBG

Molecular functions related to Blood Group Incompatibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring hexosyl groups GO:0016758 9.37 ABO A4GALT
2 ankyrin binding GO:0030506 9.32 SLC4A1 RHBG
3 glutathione hydrolase activity GO:0036374 9.26 GGT7 GGT6
4 leukotriene C4 gamma-glutamyl transferase activity GO:0103068 9.16 GGT7 GGT6
5 hypoglycin A gamma-glutamyl transpeptidase activity GO:0102953 8.96 GGT7 GGT6
6 ammonium transmembrane transporter activity GO:0008519 8.8 RHD RHCE RHBG

Sources for Blood Group Incompatibility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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