JR
MCID: BLD159
MIFTS: 28

Blood Group, Junior System (JR)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Junior System

MalaCards integrated aliases for Blood Group, Junior System:

Name: Blood Group, Junior System 58 6
Blood Group System, Junior 41
Junior Blood Group System 58
Jr 58

Classifications:



External Ids:

OMIM 58 614490

Summaries for Blood Group, Junior System

OMIM : 58 Individuals with Jr(a-) blood group lack the Jr(a) antigen on their red blood cells. These individuals may have anti-Jr(a) antibodies in their serum, which can cause transfusion reactions or hemolytic disease of the fetus or newborn. Although the clinical significance of the Jr(a-) blood group has been controversial, severe fatal hemolytic disease of the newborn has been reported. The Jr(a-) phenotype has a higher frequency in individuals of Asian descent, compared to those of European descent (summary by Kim et al., 2010 and Zelinski et al., 2012). (614490)

MalaCards based summary : Blood Group, Junior System, also known as blood group system, junior, is related to li-fraumeni syndrome and cohen syndrome. An important gene associated with Blood Group, Junior System is ABCG2 (ATP Binding Cassette Subfamily G Member 2 (Junior Blood Group)). Affiliated tissues include prostate, lung and heart.

Related Diseases for Blood Group, Junior System

Diseases related to Blood Group, Junior System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 li-fraumeni syndrome 11.1
2 cohen syndrome 11.1
3 fitz-hugh-curtis syndrome 11.1
4 prostate cancer 10.3
5 prostate cancer, hereditary, 8 10.3
6 prostate cancer, hereditary, 6 10.3
7 bladder cancer 10.2
8 pemphigus foliaceus 10.1
9 pulmonary fibrosis, idiopathic 10.1
10 pulmonary fibrosis 10.1
11 blood group, langereis system 10.0
12 ovarian cancer 10.0
13 disorganization, mouse, homolog of 10.0
14 lymphoma 10.0
15 japanese encephalitis 10.0
16 epilepsy 10.0
17 transposition of the great arteries 10.0
18 blood group--wright antigen 9.9
19 obsessive-compulsive disorder 9.9
20 rheumatoid arthritis 9.9
21 small cell cancer of the lung 9.9
22 lung cancer 9.9
23 anaplastic large cell lymphoma 9.9
24 scoliosis 9.9
25 endocarditis 9.9
26 arteriovenous malformation 9.9
27 vascular disease 9.9
28 polymyositis 9.9
29 breast cancer 9.8
30 otitis media 9.8
31 retinoblastoma 9.8
32 vesicoureteral reflux 1 9.8
33 autism 9.8
34 prostatic hyperplasia, benign 9.8
35 gallbladder disease 1 9.8
36 astigmatism 9.8
37 salla disease 9.8
38 lymphangioleiomyomatosis 9.8
39 human immunodeficiency virus type 1 9.8
40 peripheral vascular disease 9.8
41 hepatitis 9.8
42 leukemia 9.8
43 paramyloidosis 9.8
44 thrombosis 9.8
45 q fever 9.8
46 diarrhea 9.8
47 dumping syndrome 9.8
48 hepatitis c 9.8
49 prostatic adenoma 9.8
50 in situ carcinoma 9.8

Graphical network of the top 20 diseases related to Blood Group, Junior System:



Diseases related to Blood Group, Junior System

Symptoms & Phenotypes for Blood Group, Junior System

Clinical features from OMIM:

614490

Drugs & Therapeutics for Blood Group, Junior System

Search Clinical Trials , NIH Clinical Center for Blood Group, Junior System

Genetic Tests for Blood Group, Junior System

Anatomical Context for Blood Group, Junior System

MalaCards organs/tissues related to Blood Group, Junior System:

42
Prostate, Lung, Heart, Kidney, Breast, Bone, T Cells

Publications for Blood Group, Junior System

Articles related to Blood Group, Junior System:

(show top 50) (show all 1639)
# Title Authors Year
1
Endoscopic submucosal dissection using an SB Knife Jr. with clip traction method for esophageal cancer at the anastomotic site after total gastrectomy. ( 30909301 )
2019
2
Do Selective Fusions for Idiopathic Scoliosis Hold Up with Time?: Commentary on an article by Craig Louer Jr., MD, et al.: "Ten-Year Outcomes of Selective Fusions for Adolescent Idiopathic Scoliosis". ( 31045678 )
2019
3
Re: "Desvenlafaxine Versus Placebo in a Fluoxetine-Referenced Study of Children and Adolescents with Major Depressive Disorder: Design, Definitions, and Ongoing Challenges for Child and Adolescent Psychopharmacology Research" by Strawn JR and Croarkin PE (J Child Adolesc Psychopharmacol 2018;28:(5)363). ( 30874454 )
2019
4
Normative Data of the Hip Disability and Osteoarthritis Outcome Score, JR in a Healthy United States Population. ( 30879873 )
2019
5
Erratum: Holliday EB, Siker M, Chapman CH, Jagsi R, Bitterman DS, Ahmed AA, Winkfield K, Kelly M, Tarbell NJ, Deville Jr C: Achieving Gender Equity in the Radiation Oncology Physician Workforce (Advances in Radiation Oncology 2018;3:478-483). ( 30706030 )
2019
6
Pioneer in Pediatric Pathology: William A (Bill) Newton Jr (1923-). ( 30126318 )
2019
7
Stent-assisted coil embolization of anterior communicating artery aneurysms using the LVIS Jr stent. ( 30180758 )
2019
8
Endovascular Treatment of Wide-Necked Intracranial Aneurysms with the Scepter XC Balloon Catheter, with Low-Profile Visualized Intraluminal Support (LVIS) Jr. Deployment as a "Bailout" Technique. ( 30312823 )
2019
9
Production of high crystallinity type-I cellulose from Komagataeibacter hansenii JR-02 isolated from Kombucha tea. ( 30359481 )
2019
10
Japanese Surveillance of Neuroendovascular Therapy in JR-NET - Part II. Japanese Registry of NeuroEndovascular Treatment 3. Main Report. ( 30842388 )
2019
11
Autobiography of "William M. Jackson, Jr." ( 30866631 )
2019
12
A Tribute to William M. Jackson, Jr. ( 30866632 )
2019
13
Real-world Experience of Carotid Artery Stenting in Japan: Analysis of 8458 Cases from the JR-NET3 Nationwide Retrospective Multi-center Registries. ( 30880307 )
2019
14
Moody D. Wharam Jr, MD, FACR, FASTRO, July 22, 1941-August 10, 2018. ( 30900552 )
2019
15
Successful Management of the Fetal Severe Anemia Associated with Jra Alloimmunization by Intrauterine Transfusion of Jr(a+) Red Blood Cells. ( 30918730 )
2019
16
In Memoriam-Oscar Salvatierra, Jr., MD. ( 30983054 )
2019
17
Correction to: Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection by Ishida Y, Kakuni M, Bang B-R, Sugahara G, Lau DT-Y, Tateno-Mukaidani C, Li M, Gale M Jr., and Saito T. J Interferon Cytokine Res 2019;39(3):133-146. DOI: 10.1089/jir.2018.0103. ( 30990735 )
2019
18
Carrying the Torch: The Life, Work, and Values of Basil A. Pruitt, Jr., MD, FACS, COL (ret), MC, USA. ( 31033895 )
2019
19
Mbaeyi SA, Joseph SJ, Blain A, Wang X, Hariri S, MacNeil JR. Meningococcal Disease Among College-Aged Young Adults: 2014-2016. Pediatrics. 2019;143(1):e20182130. ( 31040193 )
2019
20
Changing Paradigms of Periprocedural Antithrombotic Therapy in Neuroendovascular Therapy: Analysis of JR-NET 3. ( 31068546 )
2019
21
Pharmacology and Physiology for Anesthesia, Second Edition : Hugh C. Hemmings Jr, Talmage D. Egan (Editors). Elsevier, Philadelphia, 2019, Hardcover, $207.99, 994 pages. ISBN 9780323481106. ( 31076957 )
2019
22
PROMIS Physical Function Correlates with KOOS, JR in Patients with Knee Pain. ( 31091543 )
2019
23
Development and validation of an exome-based SNP marker set for identification of the St, Jr and Jvs genomes of Thinopyrym intermedium in a wheat background. ( 30767030 )
2019
24
Treatment Outcome of Intracranial Tumor Embolization in Japan: Japanese Registry of NeuroEndovascular Therapy 3 (JR-NET3). ( 30686813 )
2019
25
The 2018 Joseph W. St. Geme, Jr. Leadership Award Address: Reflections on Mentorship. ( 30683811 )
2019
26
Charles E. Locke Jr. (1895-1929): the founder of neurosurgery at the Cleveland Clinic. ( 30660124 )
2019
27
NCRP 54th Annual Meeting, Radiation Protection Responsibility in Medicine: Dose, Benefit, Risk, and Safety Q & A (Questions for Jerrold T. Bushberg, Mythreyi Chatfield, Fred A. Mettler, Jr., Marvin Rosenstein, and Pat B. Zanzonico). ( 30585955 )
2019
28
First Person: Paul Bunn, Jr, MD, FASCO: An icon in the oncology world, he has led major cancer organizations and clinical trials and launched the University of Colorado Cancer Center. ( 30577093 )
2019
29
Erratum to: Olsen JR, Murphy JD, Huguet F, et al. Oncology Scan: Gastrointestinal Cancers - Carving Out the Optimal Local Therapies in the Gastrointestinal Tract. Int J Radiat Oncol Biol Phys 2018;102:233-242. ( 30563664 )
2019
30
Endovascular Therapy for Ruptured Vertebral Artery Dissecting Aneurysms: Results from Nationwide, Retrospective, Multi-Center Registries in Japan (JR-NET3). ( 30531151 )
2019
31
KOOS-JR Demonstrates Psychometric Limitations in Measuring Knee Health in Individuals After ACL Reconstruction. ( 30444674 )
2019
32
Silvio Vaz Jr.: Analytical chemistry applied to emerging pollutants. ( 30443772 )
2019
33
A clinical comparison of Atlas and LVIS Jr stent-assisted aneurysm coiling. ( 30077966 )
2019
34
Commentary on Nóbrega-Jr et al. "Mesial temporal lobe epilepsy with hippocampal sclerosis is infrequently associated with neuronal antibodies". ( 30451294 )
2018
35
Non-clinical evaluation of JR-051 as a biosimilar to agalsidase beta for the treatment of Fabry disease. ( 30054149 )
2018
36
Reply to: "'Who killed JR': Chronic hepatitis C or alcohol use disorders?" ( 29292094 )
2018
37
"Who killed JR": Chronic hepatitis C or alcohol use disorders? ( 29294316 )
2018
38
First person: William Kaelin Jr, MD: The scientist's discoveries have paved the way for improved treatments of kidney cancer and other diseases. ( 29630725 )
2018
39
Expert's comment concerning Grand Rounds Case entitled "pancreatic fracture: a rare complication following scoliosis surgery" by Mélodie Juricic Jr. et al. (Eur Spine J; [2017]: doi: 10.1007/s00586-017-5318-x). ( 29404695 )
2018
40
Clinical significance of antibodies to antigens in the Raph, John Milton Hagen, I, Globoside, Gill, Rh-associated glycoprotein, FORS, JR, LAN, Vel, CD59, and Augustine blood group systems. ( 30295501 )
2018
41
Ronald W. Busuttil, MD, PhD: William P. Longmire, Jr, Chair of Surgery, Chief of Liver and Pancreas Transplantation, Director, UCLA-Dumont Transplant & Liver Cancer Center. ( 29702537 )
2018
42
Erratum to: Gunther JR, Jimenez RB, Yechieli RL, et al. Introductory Radiation Oncology Curriculum: Report of a National Needs Assessment and Multi-institutional Pilot Implementation. Int J Radiat Oncol Biol Phys 2018;101:1029-1038. ( 31014796 )
2018
43
In memoriam Hugh H. McAllister, Jr., M.D. ( 30100494 )
2018
44
Michael V. Sivak, Jr, MD. ( 30128375 )
2018
45
The Person Behind the Inventor of the Heart-Lung Machine: John H. Gibbon Jr, MD (1903-1973). ( 30178889 )
2018
46
What Are the Minimal and Substantial Improvements in the HOOS and KOOS and JR Versions After Total Joint Replacement? ( 30179951 )
2018
47
Extrapolation of Normative KOOS, JR Data for the Young Patient Population Undergoing Knee Arthroplasty Procedures. ( 30279011 )
2018
48
The Primates 2018 Most-Cited Paper Award is conferred upon James R. Anderson and Gordon G. Gallup Jr. ( 30324530 )
2018
49
First person: George Sledge, Jr, MD: Former ASCO president leads breast cancer research and mentors Stanford faculty. ( 30326166 )
2018
50
Single-center experience with six-month follow-up of FRED Jr® flow diverters for intracranial aneurysms in small arteries. ( 30354188 )
2018

Variations for Blood Group, Junior System

ClinVar genetic disease variations for Blood Group, Junior System:

6 (show all 14)
# Gene Variation Type Significance SNP ID Assembly Location
1 ABCG2 NM_004827.2(ABCG2): c.1111_1112delAC (p.Thr371Leufs) deletion Affects rs387906869 GRCh38 Chromosome 4, 88113385: 88113386
2 ABCG2 NM_004827.2(ABCG2): c.1111_1112delAC (p.Thr371Leufs) deletion Affects rs387906869 GRCh37 Chromosome 4, 89034537: 89034538
3 ABCG2 NM_004827.2(ABCG2): c.736C> T (p.Arg246Ter) single nucleotide variant Affects rs200190472 GRCh37 Chromosome 4, 89039366: 89039366
4 ABCG2 NM_004827.2(ABCG2): c.736C> T (p.Arg246Ter) single nucleotide variant Affects rs200190472 GRCh38 Chromosome 4, 88118214: 88118214
5 ABCG2 NM_004827.2(ABCG2): c.376C> T (p.Gln126Ter) single nucleotide variant association rs72552713 GRCh37 Chromosome 4, 89052957: 89052957
6 ABCG2 NM_004827.2(ABCG2): c.376C> T (p.Gln126Ter) single nucleotide variant association rs72552713 GRCh38 Chromosome 4, 88131805: 88131805
7 ABCG2 NM_004827.2(ABCG2): c.34G> A (p.Val12Met) single nucleotide variant Affects, association rs2231137 GRCh37 Chromosome 4, 89061114: 89061114
8 ABCG2 NM_004827.2(ABCG2): c.34G> A (p.Val12Met) single nucleotide variant Affects, association rs2231137 GRCh38 Chromosome 4, 88139962: 88139962
9 ABCG2 NM_004827.2(ABCG2): c.706C> T (p.Arg236Ter) single nucleotide variant association rs140207606 GRCh37 Chromosome 4, 89039396: 89039396
10 ABCG2 NM_004827.2(ABCG2): c.706C> T (p.Arg236Ter) single nucleotide variant association rs140207606 GRCh38 Chromosome 4, 88118244: 88118244
11 ABCG2 NM_004827.2(ABCG2): c.791_792delTT (p.Leu264Hisfs) deletion Affects rs387906870 GRCh37 Chromosome 4, 89039310: 89039311
12 ABCG2 NM_004827.2(ABCG2): c.791_792delTT (p.Leu264Hisfs) deletion Affects rs387906870 GRCh38 Chromosome 4, 88118158: 88118159
13 ABCG2 NM_004827.2(ABCG2): c.421C> A (p.Gln141Lys) single nucleotide variant drug response rs2231142 GRCh37 Chromosome 4, 89052323: 89052323
14 ABCG2 NM_004827.2(ABCG2): c.421C> A (p.Gln141Lys) single nucleotide variant drug response rs2231142 GRCh38 Chromosome 4, 88131171: 88131171

Expression for Blood Group, Junior System

Search GEO for disease gene expression data for Blood Group, Junior System.

Pathways for Blood Group, Junior System

GO Terms for Blood Group, Junior System

Sources for Blood Group, Junior System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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