LAN
MCID: BLD148
MIFTS: 20

Blood Group, Langereis System (LAN)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Langereis System

MalaCards integrated aliases for Blood Group, Langereis System:

Name: Blood Group, Langereis System 57
Blood Group System, Langereis 39
Lan 57

Classifications:



External Ids:

OMIM® 57 111600
MedGen 41 C3276339

Summaries for Blood Group, Langereis System

OMIM® : 57 Individuals with Lan(-) blood group lack the Lan antigen on their red blood cells. These individuals may have anti-Lan antibodies in their serum, which can cause transfusion reactions or hemolytic disease of the fetus or newborn. The Lan(-) blood group is only clinically significant in transfusion settings or during pregnancy; otherwise Lan(-) individuals have no clinical features (summary by Helias et al., 2012). (111600) (Updated 20-May-2021)

MalaCards based summary : Blood Group, Langereis System, also known as blood group system, langereis, is related to aging and neuroblastoma. An important gene associated with Blood Group, Langereis System is ABCB6 (ATP Binding Cassette Subfamily B Member 6 (Langereis Blood Group)). Affiliated tissues include pituitary, bone and lung.

Related Diseases for Blood Group, Langereis System

Diseases related to Blood Group, Langereis System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 aging 10.4
2 neuroblastoma 10.4
3 hemolytic disease due to fetomaternal alloimmunization 10.1
4 pneumonia 10.0
5 lung cancer 10.0
6 autoimmune lymphoproliferative syndrome 10.0
7 breast cancer 9.8
8 type 2 diabetes mellitus 9.8
9 osteoporosis 9.8
10 prostate cancer 9.8
11 small cell cancer of the lung 9.8
12 body mass index quantitative trait locus 11 9.8
13 body mass index quantitative trait locus 9 9.8
14 body mass index quantitative trait locus 8 9.8
15 meningioma, familial 9.8
16 body mass index quantitative trait locus 4 9.8
17 body mass index quantitative trait locus 10 9.8
18 body mass index quantitative trait locus 7 9.8
19 human immunodeficiency virus type 1 9.8
20 bone mineral density quantitative trait locus 8 9.8
21 body mass index quantitative trait locus 12 9.8
22 body mass index quantitative trait locus 14 9.8
23 bone mineral density quantitative trait locus 15 9.8
24 body mass index quantitative trait locus 18 9.8
25 body mass index quantitative trait locus 19 9.8
26 disease by infectious agent 9.8
27 tongue carcinoma 9.8
28 urolithiasis 9.8
29 intracranial meningioma 9.8
30 mumps 9.8
31 gastric ulcer 9.8
32 leech infestation 9.8
33 pertussis 9.8
34 tinea pedis 9.8
35 dementia 9.8
36 porphyria 9.8
37 frozen shoulder 9.8
38 pyuria 9.8
39 dermatomycosis 9.8
40 neuroendocrine carcinoma 9.8
41 acromegaly 9.8
42 kidney cancer 9.8
43 severe acute respiratory syndrome 9.8
44 pituitary adenoma 9.8
45 secretory meningioma 9.8
46 lymphoplasmacyte-rich meningioma 9.8
47 functioning pituitary adenoma 9.8
48 compartment syndrome 9.8
49 influenza 9.8
50 dermatophytosis 9.8

Graphical network of the top 20 diseases related to Blood Group, Langereis System:



Diseases related to Blood Group, Langereis System

Symptoms & Phenotypes for Blood Group, Langereis System

Clinical features from OMIM®:

111600 (Updated 20-May-2021)

Drugs & Therapeutics for Blood Group, Langereis System

Search Clinical Trials , NIH Clinical Center for Blood Group, Langereis System

Genetic Tests for Blood Group, Langereis System

Anatomical Context for Blood Group, Langereis System

MalaCards organs/tissues related to Blood Group, Langereis System:

40
Pituitary, Bone, Lung, Kidney, Thyroid, Breast, Prostate

Publications for Blood Group, Langereis System

Articles related to Blood Group, Langereis System:

# Title Authors PMID Year
1
ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis. 61 57 6
22246506 2012
2
The ABCB6 mutation p.Arg192Trp is a recessive mutation causing the Lan- blood type. 57 6
22958180 2013
3
The rare red cell phenotype Lan negative in Japanese. 57
6506188 1984
4
Hemolytic disease of the newborn due to anti-Lan. 57
6679383 1983
5
Haemolytic disease of the newborn caused by anti-Lan antibody. 57
5790273 1969
6
Efficient purification and reconstitution of ATP binding cassette transporter B6 (ABCB6) for functional and structural studies. 61
23792964 2013

Variations for Blood Group, Langereis System

ClinVar genetic disease variations for Blood Group, Langereis System:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ABCB6 NM_005689.4(ABCB6):c.717G>A (p.Trp239Ter) SNV Affects 30477 rs148458820 GRCh37: 2:220081525-220081525
GRCh38: 2:219216803-219216803
2 ABCB6 NM_005689.4(ABCB6):c.1942C>T (p.Arg648Ter) SNV Affects 30479 rs376664522 GRCh37: 2:220077135-220077135
GRCh38: 2:219212413-219212413
3 ABCB6 NM_005689.4(ABCB6):c.2256+2T>G SNV Affects 30481 rs1559234527 GRCh37: 2:220075431-220075431
GRCh38: 2:219210709-219210709
4 ABCB6 NM_005689.4(ABCB6):c.1111_1117CGGATCG[1] (p.Ala373fs) Microsatellite Affects 253006 rs765925019 GRCh37: 2:220080749-220080755
GRCh38: 2:219216027-219216033
5 ABCB6 NM_005689.4(ABCB6):c.1656-1G>A SNV Affects 253007 rs879255549 GRCh37: 2:220078225-220078225
GRCh38: 2:219213503-219213503
6 ABCB6 NM_005689.4(ABCB6):c.1981_1982TC[2] (p.Leu662fs) Microsatellite Affects 30480 rs387906909 GRCh37: 2:220075813-220075814
GRCh38: 2:219211091-219211092
7 ABCB6 NM_005689.4(ABCB6):c.1690_1691del (p.Met564fs) Deletion Affects 30478 rs387906908 GRCh37: 2:220078189-220078190
GRCh38: 2:219213467-219213468
8 ABCB6 NM_005689.4(ABCB6):c.574C>T (p.Arg192Trp) SNV Affects 217872 rs149202834 GRCh37: 2:220082505-220082505
GRCh38: 2:219217783-219217783

Expression for Blood Group, Langereis System

Search GEO for disease gene expression data for Blood Group, Langereis System.

Pathways for Blood Group, Langereis System

GO Terms for Blood Group, Langereis System

Sources for Blood Group, Langereis System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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41 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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