LE
MCID: BLD171
MIFTS: 20

Blood Group, Lewis System (LE)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Lewis System

MalaCards integrated aliases for Blood Group, Lewis System:

Name: Blood Group, Lewis System 57
Lewis Blood Group System; Les 57
Lewis Blood Group System 57
Les 57
Le 57

Classifications:



External Ids:

OMIM® 57 618983

Summaries for Blood Group, Lewis System

OMIM® : 57 The primary antigens of the Lewis blood group system, Le(a) and Le(b), are not synthesized by red cells but are introduced into the red cell membrane from plasma. The terminology Le(a) and Le(b) is misleading, as these antigens are not allelic. The Le gene, FUT3, encodes an alpha-1,4-L-fucosyltransferase that catalyzes the addition of a fucose residue to the H antigen to produce Le(b) or to the precursor of H to produce Le(a). The presence of H antigen in secretions is governed by the FUT2 gene (182100). Thus, red cells of most H secretors, who have a functional FUT2 enzyme, are Le(a-b+), and those of H nonsecretors (see 182100.0001), who have a nonfunctional FUT2 enzyme, are Le(a+b-). FUT3 can also convert A antigen to ALe(b) and B antigen to BLe(b) (see 110300). About 6% of white people and 25% of black people are homozygous for loss-of-function FUT2 mutations (e.g., 111100.0001) and therefore have Le(a-b-) red cells and lack Lewis substances in their secretions. In Asia, the red cell phenotype Le(a+b+) is common and results from a weak secretor allele in FUT2 (182100.0002). The Le(c) and Le(d) antigens represent precursors of the Le antigens and are present in increased quantities in plasma of Le(a-b-) individuals. The Le(x) and Le(y) antigens are isomers of Le(a) and Le(b), respectively, and are not present in substantial quantities on red cells. Although Le antibodies are relatively common, hemolytic transfusion reactions are rare, and Le antibodies do not cause serious hemolytic disease of the newborn (summary by Daniels, 2002). (618983) (Updated 05-Mar-2021)

MalaCards based summary : Blood Group, Lewis System, also known as lewis blood group system; les, is related to covid-19 and severe acute respiratory syndrome. An important gene associated with Blood Group, Lewis System is FUT3 (Fucosyltransferase 3 (Lewis Blood Group)). Affiliated tissues include kidney and liver.

Related Diseases for Blood Group, Lewis System

Diseases related to Blood Group, Lewis System via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 255)
# Related Disease Score Top Affiliating Genes
1 covid-19 10.5
2 severe acute respiratory syndrome 10.3
3 gastroesophageal reflux 10.2
4 disease of mental health 10.2
5 major depressive disorder 10.1
6 mental depression 10.1
7 enthesopathy 10.1
8 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
9 depression 10.1
10 dermatitis, atopic 10.0
11 social phobia 10.0
12 post-traumatic stress disorder 10.0
13 dermatitis 10.0
14 anxiety 10.0
15 esophagitis 10.0
16 generalized anxiety disorder 10.0
17 personality disorder 10.0
18 myopathy 10.0
19 ebola hemorrhagic fever 10.0
20 panic disorder 10.0
21 achalasia 10.0
22 developmental coordination disorder 10.0
23 47,xyy 10.0
24 48,xyyy 10.0
25 developmental dyspraxia 10.0
26 systemic lupus erythematosus 9.9
27 schizophrenia 9.9
28 cystic fibrosis 9.9
29 lymphoma 9.9
30 pertussis 9.9
31 avoidant personality disorder 9.9
32 hepatitis c 9.9
33 psychotic disorder 9.9
34 skin disease 9.9
35 pustulosis of palm and sole 9.9
36 influenza 9.9
37 psoriasis 9.9
38 fasciitis 9.9
39 dysphagia 9.9
40 alcohol dependence 9.8
41 bladder cancer 9.8
42 major affective disorder 1 9.8
43 migraine with or without aura 1 9.8
44 neural tube defects 9.8
45 temporal arteritis 9.8
46 immune deficiency disease 9.8
47 arts syndrome 9.8
48 pulmonary disease, chronic obstructive 9.8
49 hepatitis c virus 9.8
50 barrett esophagus 9.8

Graphical network of the top 20 diseases related to Blood Group, Lewis System:



Diseases related to Blood Group, Lewis System

Symptoms & Phenotypes for Blood Group, Lewis System

Clinical features from OMIM®:

618983 (Updated 05-Mar-2021)

Drugs & Therapeutics for Blood Group, Lewis System

Search Clinical Trials , NIH Clinical Center for Blood Group, Lewis System

Genetic Tests for Blood Group, Lewis System

Anatomical Context for Blood Group, Lewis System

MalaCards organs/tissues related to Blood Group, Lewis System:

40
Kidney, Liver

Publications for Blood Group, Lewis System

Articles related to Blood Group, Lewis System:

(show top 50) (show all 61)
# Title Authors PMID Year
1
Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa. 57
9703429 1998
2
Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels. 57
8943285 1996
3
Histo-blood group Lewis genotyping from human hairs and blood. 57
8914633 1996
4
Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19. 57
7656588 1995
5
Molecular genetic analysis of the human Lewis histo-blood group system. 57
7961897 1994
6
Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. 57
8018146 1993
7
Association of the Lewis blood-group phenotype with recurrent urinary tract infections in women. 57
2922027 1989
8
The locus for apolipoprotein E (apoE) is close to the Lutheran (Lu) blood group locus on chromosome 19. 57
6745937 1984
9
Lewis blood-type may affect the incidence of gastrointestinal cancer. 57
6177980 1982
10
Proceedings: Probable genetic linkage between the loci for the Lewis blood group and complement C3. 57
4827488 1974
11
An enzymatic basis for Lewis blood types in man. 57
5796361 1969
12
Divergence in phenotyping and genotyping analysis of the Lewis histo-blood group system. 61
33429462 2021
13
Routine indirect antiglobulin testing of blood donors-a further step toward blood safety: an experience from a tertiary care center in northern India. 61
33112633 2020
14
An update on the Lewis blood group system. 61
31246491 2019
15
Rapid milk group classification by 1H NMR analysis of Le and H epitopes in human milk oligosaccharide donor samples. 61
24789815 2014
16
Clinical significance of antibody specificities to M, N and Lewis blood group system. 61
25161347 2014
17
The Lewis histo-blood group system: molecular analysis of the 59T>G, 508G>A, and 1067T>A polymorphisms in an Amazonian population. 61
23922852 2013
18
[Lewis blood group system and their antibodies]. 61
20942181 2010
19
Lewis blood group system review. 61
20406017 2009
20
[Lewis blood group system and their antibodies (anti Le(a), anti-Le(b))]. 61
16111365 2005
21
Human milk glycans protect infants against enteric pathogens. 61
16011458 2005
22
Detection of four human milk groups with respect to Lewis-blood-group-dependent oligosaccharides by serologic and chromatographic analysis. 61
11787693 2001
23
[Lewis blood group system and their antibodies (anti-Le(a), anti-Le(b))]. 61
10635921 1999
24
Typing for the human lewis blood group system by quantitative fluorescence-activated flow cytometry: large differences in antigen presentation on erythrocytes between A(1), A(2), B, O phenotypes. 61
10717603 1999
25
Detection of four human milk groups with respect to Lewis blood group dependent oligosaccharides. 61
9511984 1997
26
DNA sequencing and screening for point mutations in the human Lewis (FUT3) gene enables molecular genotyping of the human Lewis blood group system. 61
8801770 1996
27
Comparative study of CA242 and CA19-9 for the diagnosis of pancreatic cancer. 61
8080734 1994
28
In vitro inhibition of adhesion of Candida albicans clinical isolates to human buccal epithelial cells by Fuc alpha 1----2Gal beta-bearing complex carbohydrates. 61
2019432 1991
29
Antigen CA 19-9: presence in mucosa of nondiseased müllerian duct derivatives and marker for differentiation in their carcinomas. 61
2002982 1991
30
Differential tissue expression of the Lewis blood group antigens: enzymatic, immunohistologic, and immunochemical evidence for Lewis a and b antigen expression in Le(a-b-) individuals. 61
2001461 1991
31
The Lewis blood group system among Chinese in Taiwan. 61
1778604 1991
32
Serum tumor markers for pancreatic carcinoma. 61
2100561 1990
33
A study of the Lewis blood group system in the Singapore population. 61
2802505 1989
34
The interaction between the Lewis blood group system and HLA-matching in renal transplantation. 61
3285539 1988
35
The Lewis blood group system in liver transplantation. 61
3321626 1987
36
Immunochemistry of the Lewis blood-group system: isolation and structures of Lewis-c active and related glycosphingolipids from the plasma of blood-group O Le(a-b-) nonsecretors. 61
2423032 1986
37
The role of the Lewis antigen system in renal transplantation and allograft rejection. 61
6374307 1984
38
Characterization of monoclonal antibodies specific for the Lewis a human blood group determinant. 61
6833281 1983
39
A new technique in quantitative immunohematology: solid-phase kinetic enzyme-linked immunosorbent assay. 61
6362193 1983
40
Immunological factors influencing renal graft survival. 61
6344752 1983
41
[Current immunologic aspects of kidney transplantation]. 61
6758280 1982
42
Immunochemistry of the Lewis blood-group system: investigations on the Lec antigen. 61
6179793 1982
43
Monoclonal antibodies directed against the human Leb blood group antigen. 61
7309759 1981
44
Immunochemistry of the Lewis-blood-group system: mass spectrometric analysis of permethylated Le(a)-, Le(b)-, and H-type 1 (LedH) blood-group active and related glycosphingolipids from human plasma. 61
7294834 1981
45
Immunochemistry of the Lewis-blood-group system: partial characterization of Le(a)-, Le(b)-, and H-type 1 (LedH)-blood-group active glycosphingolipids from human plasma. 61
7294833 1981
46
Immunochemistry of the Lewis-blood-group system: proton nuclear magnetic resonance study of plasmatic Lewis-blood-group-active glycosphingolipids and related substances. 61
7294835 1981
47
Immunochemistry of the Lewis blood-group system. III. Studies on the molecular basis of the Lex property. 61
7018082 1981
48
The Lewis antigen system and its relevance for clinical transplantation. 61
382664 1979
49
Influence of the Lewis blood group system on clinical kidney transplantation. 61
398510 1979
50
Distribution of the Lewis blood-group system in 331 members of JNA. 61
606236 1977

Variations for Blood Group, Lewis System

Expression for Blood Group, Lewis System

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Pathways for Blood Group, Lewis System

GO Terms for Blood Group, Lewis System

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