LE
MCID: BLD171
MIFTS: 19

Blood Group, Lewis System (LE)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Lewis System

MalaCards integrated aliases for Blood Group, Lewis System:

Name: Blood Group, Lewis System 57
Lewis Blood Group System; Les 57
Lewis Blood Group System 57
Les 57
Le 57

Classifications:



External Ids:

OMIM® 57 618983

Summaries for Blood Group, Lewis System

OMIM® : 57 The primary antigens of the Lewis blood group system, Le(a) and Le(b), are not synthesized by red cells but are introduced into the red cell membrane from plasma. The terminology Le(a) and Le(b) is misleading, as these antigens are not allelic. The Le gene, FUT3, encodes an alpha-1,4-L-fucosyltransferase that catalyzes the addition of a fucose residue to the H antigen to produce Le(b) or to the precursor of H to produce Le(a). The presence of H antigen in secretions is governed by the FUT2 gene (182100). Thus, red cells of most H secretors, who have a functional FUT2 enzyme, are Le(a-b+), and those of H nonsecretors (see 182100.0001), who have a nonfunctional FUT2 enzyme, are Le(a+b-). FUT3 can also convert A antigen to ALe(b) and B antigen to BLe(b) (see 110300). About 6% of white people and 25% of black people are homozygous for loss-of-function FUT2 mutations (e.g., 111100.0001) and therefore have Le(a-b-) red cells and lack Lewis substances in their secretions. In Asia, the red cell phenotype Le(a+b+) is common and results from a weak secretor allele in FUT2 (182100.0002). The Le(c) and Le(d) antigens represent precursors of the Le antigens and are present in increased quantities in plasma of Le(a-b-) individuals. The Le(x) and Le(y) antigens are isomers of Le(a) and Le(b), respectively, and are not present in substantial quantities on red cells. Although Le antibodies are relatively common, hemolytic transfusion reactions are rare, and Le antibodies do not cause serious hemolytic disease of the newborn (summary by Daniels, 2002). (618983) (Updated 05-Apr-2021)

MalaCards based summary : Blood Group, Lewis System, also known as lewis blood group system; les, is related to covid-19 and disease of mental health. An important gene associated with Blood Group, Lewis System is FUT3 (Fucosyltransferase 3 (Lewis Blood Group)). Affiliated tissues include kidney.

Related Diseases for Blood Group, Lewis System

Diseases related to Blood Group, Lewis System via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 254, show less)
# Related Disease Score Top Affiliating Genes
1 covid-19 10.3
2 disease of mental health 10.3
3 gastroesophageal reflux 10.2
4 severe acute respiratory syndrome 10.2
5 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
6 major depressive disorder 10.1
7 mental depression 10.1
8 enthesopathy 10.1
9 depression 10.1
10 dermatitis, atopic 10.0
11 social phobia 10.0
12 post-traumatic stress disorder 10.0
13 dermatitis 10.0
14 47,xyy 10.0
15 systemic lupus erythematosus 10.0
16 anxiety 10.0
17 esophagitis 10.0
18 generalized anxiety disorder 10.0
19 personality disorder 10.0
20 myopathy 10.0
21 ebola hemorrhagic fever 10.0
22 pustulosis of palm and sole 10.0
23 panic disorder 10.0
24 psoriasis 10.0
25 achalasia 10.0
26 developmental coordination disorder 10.0
27 48,xyyy 10.0
28 developmental dyspraxia 10.0
29 schizophrenia 9.9
30 cystic fibrosis 9.9
31 cryptogenic organizing pneumonia 9.9
32 lymphoma 9.9
33 pertussis 9.9
34 avoidant personality disorder 9.9
35 hepatitis c 9.9
36 melanoma 9.9
37 psychotic disorder 9.9
38 skin disease 9.9
39 influenza 9.9
40 fasciitis 9.9
41 dysphagia 9.9
42 bladder cancer 9.8
43 major affective disorder 1 9.8
44 migraine with or without aura 1 9.8
45 neural tube defects 9.8
46 temporal arteritis 9.8
47 immune deficiency disease 9.8
48 arts syndrome 9.8
49 pulmonary disease, chronic obstructive 9.8
50 hepatitis c virus 9.8
51 barrett esophagus 9.8
52 alacrima, achalasia, and mental retardation syndrome 9.8
53 disease by infectious agent 9.8
54 mucositis 9.8
55 polymyositis 9.8
56 parkinsonism 9.8
57 venous insufficiency 9.8
58 diarrhea 9.8
59 panniculitis 9.8
60 glomerulonephritis 9.8
61 bronchiolitis 9.8
62 substance abuse 9.8
63 acute kidney failure 9.8
64 mood disorder 9.8
65 gastritis 9.8
66 acquired immunodeficiency syndrome 9.8
67 t-cell lymphoblastic leukemia/lymphoma 9.8
68 vasculitis 9.8
69 lupus erythematosus 9.8
70 alopecia 9.8
71 substance dependence 9.8
72 myotonic dystrophy 9.8
73 leukemia, t-cell, chronic 9.8
74 macrophagic myofasciitis 9.8
75 malakoplakia 9.8
76 mycobacterium avium complex infections 9.8
77 back pain 9.8
78 head injury 9.8
79 pik3ca-related overgrowth syndrome 9.8
80 aortic aneurysm, familial abdominal, 1 9.7
81 alcohol dependence 9.7
82 atherosclerosis susceptibility 9.7
83 autoimmune disease 9.7
84 cleft palate, isolated 9.7
85 esophageal cancer 9.7
86 lymphoma, mucosa-associated lymphoid type 9.7
87 hair whorl 9.7
88 hernia, hiatus 9.7
89 huntington disease 9.7
90 leukemia, chronic lymphocytic 9.7
91 meralgia paraesthetica, familial 9.7
92 myotonic dystrophy 1 9.7
93 obsessive-compulsive disorder 9.7
94 osteoporosis 9.7
95 ovarian cancer 9.7
96 paroxysmal extreme pain disorder 9.7
97 pneumothorax, primary spontaneous 9.7
98 schistosoma mansoni infection, susceptibility/ 9.7
99 spondylolisthesis 9.7
100 triiodothyronine receptor auxiliary protein 9.7
101 down syndrome 9.7
102 varicose veins 9.7
103 anemia, autoimmune hemolytic 9.7
104 anencephaly 9.7
105 lymphoma, hodgkin, classic 9.7
106 hutterite cerebroosteonephrodysplasia syndrome 9.7
107 leprosy 3 9.7
108 osteogenic sarcoma 9.7
109 aging 9.7
110 helicobacter pylori infection 9.7
111 astigmatism 9.7
112 macular degeneration, age-related, 1 9.7
113 ventricular fibrillation, paroxysmal familial, 1 9.7
114 cervical cancer 9.7
115 lymphoma, non-hodgkin, familial 9.7
116 body mass index quantitative trait locus 1 9.7
117 lymphangioleiomyomatosis 9.7
118 endometrial cancer 9.7
119 phobia, specific 9.7
120 granulomatosis with polyangiitis 9.7
121 major affective disorder 5 9.7
122 major affective disorder 6 9.7
123 bone mineral density quantitative trait locus 8 9.7
124 major affective disorder 8 9.7
125 major affective disorder 9 9.7
126 lung cancer susceptibility 3 9.7
127 fatty liver disease, nonalcoholic 1 9.7
128 bone mineral density quantitative trait locus 15 9.7
129 cholangitis, primary sclerosing 9.7
130 bacteremia 2 9.7
131 leptin deficiency or dysfunction 9.7
132 chorea, childhood-onset, with psychomotor retardation 9.7
133 helix syndrome 9.7
134 neurodevelopmental, jaw, eye, and digital syndrome 9.7
135 angina pectoris 9.7
136 acute diarrhea 9.7
137 variola major 9.7
138 inflammatory bowel disease 9.7
139 mantle cell lymphoma 9.7
140 sleep apnea 9.7
141 infective endocarditis 9.7
142 sexual disorder 9.7
143 pain agnosia 9.7
144 microscopic colitis 9.7
145 non-alcoholic fatty liver disease 9.7
146 mild cognitive impairment 9.7
147 cycloplegia 9.7
148 endocarditis 9.7
149 hydrocephalus 9.7
150 amnestic disorder 9.7
151 antisocial personality disorder 9.7
152 hydronephrosis 9.7
153 esophageal varix 9.7
154 pulmonary edema 9.7
155 myopia 9.7
156 leiomyoma 9.7
157 choreatic disease 9.7
158 transient global amnesia 9.7
159 dementia 9.7
160 uveitis 9.7
161 megaesophagus 9.7
162 cholestasis 9.7
163 patent foramen ovale 9.7
164 amenorrhea 9.7
165 schistosomiasis 9.7
166 peptic esophagitis 9.7
167 sclerosing cholangitis 9.7
168 hypothyroidism 9.7
169 hereditary angioedema 9.7
170 cholera 9.7
171 angioedema 9.7
172 alcohol use disorder 9.7
173 thrombocytopenia due to platelet alloimmunization 9.7
174 thrombocytopenia 9.7
175 keratosis 9.7
176 pneumothorax 9.7
177 duodenal ulcer 9.7
178 mononeuritis multiplex 9.7
179 hyperuricemia 9.7
180 leiomyosarcoma 9.7
181 constipation 9.7
182 dental caries 9.7
183 spondylosis 9.7
184 gastroenteritis 9.7
185 acromegaly 9.7
186 papillary conjunctivitis 9.7
187 basal cell carcinoma 9.7
188 agammaglobulinemia 9.7
189 bronchiolitis obliterans 9.7
190 churg-strauss syndrome 9.7
191 glioblastoma 9.7
192 tracheal stenosis 9.7
193 neurodermatitis 9.7
194 bipolar disorder 9.7
195 angiomyolipoma 9.7
196 skin carcinoma 9.7
197 mixed connective tissue disease 9.7
198 aortic aneurysm 9.7
199 theileriasis 9.7
200 dyslexia 9.7
201 bile duct cancer 9.7
202 prostate disease 9.7
203 benign ependymoma 9.7
204 thyroid gland disease 9.7
205 liver cirrhosis 9.7
206 human immunodeficiency virus infectious disease 9.7
207 anterograde amnesia 9.7
208 dystonia 9.7
209 cellular ependymoma 9.7
210 kidney disease 9.7
211 hemolytic anemia 9.7
212 eosinophilic pneumonia 9.7
213 phobic disorder 9.7
214 agoraphobia 9.7
215 congestive heart failure 9.7
216 conjunctivitis 9.7
217 severe combined immunodeficiency 9.7
218 connective tissue disease 9.7
219 spinal stenosis 9.7
220 compartment syndrome 9.7
221 b-cell lymphoma 9.7
222 hyperthyroidism 9.7
223 myocarditis 9.7
224 osteoarthritis 9.7
225 kidney angiomyolipoma 9.7
226 eating disorder 9.7
227 smallpox 9.7
228 parasitic helminthiasis infectious disease 9.7
229 actinic keratosis 9.7
230 degenerative disc disease 9.7
231 macroglobulinemia 9.7
232 cholangitis 9.7
233 otitis externa 9.7
234 pulmonary embolism 9.7
235 chronic eosinophilic pneumonia 9.7
236 encephalitis 9.7
237 babesiosis 9.7
238 drug dependence 9.7
239 hypereosinophilic syndrome 9.7
240 glioma 9.7
241 haemophilus influenzae 9.7
242 hansen's disease 9.7
243 human t-cell leukemia virus type 1 9.7
244 microscopic polyangiitis 9.7
245 ovarian epithelial cancer 9.7
246 pediatric acute-onset neuropsychiatric syndrome 9.7
247 thalassemia 9.7
248 uterine sarcoma 9.7
249 anoxia 9.7
250 hypersomnia 9.7
251 paraneoplastic syndromes 9.7
252 paresthesia 9.7
253 spasticity 9.7
254 glial tumor 9.7

Graphical network of the top 20 diseases related to Blood Group, Lewis System:



Diseases related to Blood Group, Lewis System

Symptoms & Phenotypes for Blood Group, Lewis System

Clinical features from OMIM®:

618983 (Updated 05-Apr-2021)

Drugs & Therapeutics for Blood Group, Lewis System

Search Clinical Trials , NIH Clinical Center for Blood Group, Lewis System

Genetic Tests for Blood Group, Lewis System

Anatomical Context for Blood Group, Lewis System

MalaCards organs/tissues related to Blood Group, Lewis System:

40
Kidney

Publications for Blood Group, Lewis System

Articles related to Blood Group, Lewis System:

(showing 61, show less)
# Title Authors PMID Year
1
Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa. 57
9703429 1998
2
Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels. 57
8943285 1996
3
Histo-blood group Lewis genotyping from human hairs and blood. 57
8914633 1996
4
Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19. 57
7656588 1995
5
Molecular genetic analysis of the human Lewis histo-blood group system. 57
7961897 1994
6
Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. 57
8018146 1993
7
Association of the Lewis blood-group phenotype with recurrent urinary tract infections in women. 57
2922027 1989
8
The locus for apolipoprotein E (apoE) is close to the Lutheran (Lu) blood group locus on chromosome 19. 57
6745937 1984
9
Lewis blood-type may affect the incidence of gastrointestinal cancer. 57
6177980 1982
10
Proceedings: Probable genetic linkage between the loci for the Lewis blood group and complement C3. 57
4827488 1974
11
An enzymatic basis for Lewis blood types in man. 57
5796361 1969
12
Divergence in phenotyping and genotyping analysis of the Lewis histo-blood group system. 61
33429462 2021
13
Routine indirect antiglobulin testing of blood donors-a further step toward blood safety: an experience from a tertiary care center in northern India. 61
33112633 2020
14
An update on the Lewis blood group system. 61
31246491 2019
15
Rapid milk group classification by 1H NMR analysis of Le and H epitopes in human milk oligosaccharide donor samples. 61
24789815 2014
16
Clinical significance of antibody specificities to M, N and Lewis blood group system. 61
25161347 2014
17
The Lewis histo-blood group system: molecular analysis of the 59T>G, 508G>A, and 1067T>A polymorphisms in an Amazonian population. 61
23922852 2013
18
[Lewis blood group system and their antibodies]. 61
20942181 2010
19
Lewis blood group system review. 61
20406017 2009
20
[Lewis blood group system and their antibodies (anti Le(a), anti-Le(b))]. 61
16111365 2005
21
Human milk glycans protect infants against enteric pathogens. 61
16011458 2005
22
Detection of four human milk groups with respect to Lewis-blood-group-dependent oligosaccharides by serologic and chromatographic analysis. 61
11787693 2001
23
[Lewis blood group system and their antibodies (anti-Le(a), anti-Le(b))]. 61
10635921 1999
24
Typing for the human lewis blood group system by quantitative fluorescence-activated flow cytometry: large differences in antigen presentation on erythrocytes between A(1), A(2), B, O phenotypes. 61
10717603 1999
25
Detection of four human milk groups with respect to Lewis blood group dependent oligosaccharides. 61
9511984 1997
26
DNA sequencing and screening for point mutations in the human Lewis (FUT3) gene enables molecular genotyping of the human Lewis blood group system. 61
8801770 1996
27
Comparative study of CA242 and CA19-9 for the diagnosis of pancreatic cancer. 61
8080734 1994
28
In vitro inhibition of adhesion of Candida albicans clinical isolates to human buccal epithelial cells by Fuc alpha 1----2Gal beta-bearing complex carbohydrates. 61
2019432 1991
29
Antigen CA 19-9: presence in mucosa of nondiseased müllerian duct derivatives and marker for differentiation in their carcinomas. 61
2002982 1991
30
Differential tissue expression of the Lewis blood group antigens: enzymatic, immunohistologic, and immunochemical evidence for Lewis a and b antigen expression in Le(a-b-) individuals. 61
2001461 1991
31
The Lewis blood group system among Chinese in Taiwan. 61
1778604 1991
32
Serum tumor markers for pancreatic carcinoma. 61
2100561 1990
33
A study of the Lewis blood group system in the Singapore population. 61
2802505 1989
34
The interaction between the Lewis blood group system and HLA-matching in renal transplantation. 61
3285539 1988
35
The Lewis blood group system in liver transplantation. 61
3321626 1987
36
Immunochemistry of the Lewis blood-group system: isolation and structures of Lewis-c active and related glycosphingolipids from the plasma of blood-group O Le(a-b-) nonsecretors. 61
2423032 1986
37
The role of the Lewis antigen system in renal transplantation and allograft rejection. 61
6374307 1984
38
Characterization of monoclonal antibodies specific for the Lewis a human blood group determinant. 61
6833281 1983
39
Immunological factors influencing renal graft survival. 61
6344752 1983
40
A new technique in quantitative immunohematology: solid-phase kinetic enzyme-linked immunosorbent assay. 61
6362193 1983
41
[Current immunologic aspects of kidney transplantation]. 61
6758280 1982
42
Immunochemistry of the Lewis blood-group system: investigations on the Lec antigen. 61
6179793 1982
43
Monoclonal antibodies directed against the human Leb blood group antigen. 61
7309759 1981
44
Immunochemistry of the Lewis-blood-group system: proton nuclear magnetic resonance study of plasmatic Lewis-blood-group-active glycosphingolipids and related substances. 61
7294835 1981
45
Immunochemistry of the Lewis-blood-group system: mass spectrometric analysis of permethylated Le(a)-, Le(b)-, and H-type 1 (LedH) blood-group active and related glycosphingolipids from human plasma. 61
7294834 1981
46
Immunochemistry of the Lewis-blood-group system: partial characterization of Le(a)-, Le(b)-, and H-type 1 (LedH)-blood-group active glycosphingolipids from human plasma. 61
7294833 1981
47
Immunochemistry of the Lewis blood-group system. III. Studies on the molecular basis of the Lex property. 61
7018082 1981
48
The Lewis antigen system and its relevance for clinical transplantation. 61
382664 1979
49
Influence of the Lewis blood group system on clinical kidney transplantation. 61
398510 1979
50
Distribution of the Lewis blood-group system in 331 members of JNA. 61
606236 1977
51
[Role of Lewis blood group system in blood transfusion complications]. 61
1228762 1975
52
Le-x, the spurned antigen of the Lewis blood group system. 61
4601855 1974
53
[Serologic incompatibility in Lewis blood group system]. 61
4647900 1972
54
The ABO and Lewis blood-group system. Immunochemistry, genetics and relation to human disease. 61
4888078 1969
55
A BRIEF REVIEW OF THE LEWIS BLOOD GROUP SYSTEM. 61
14137478 1964
56
[A case of hemolytic disease of newborn probably due to antibodies of Lewis blood group system]. 61
13530913 1957
57
Specific inhibition studies relating to the Lewis blood-group system. 61
13483592 1957
58
[Clinical importance of Lewis blood group system]. 61
13255832 1955
59
[The significance of the Lewis blood group system for the pathogenesis of hemolytic disease of the newborn]. 61
13188367 1954
60
The lewis blood group system and the X-system in 5 tables. 61
14818694 1951
61
Lewis blood-group system. 61
18109172 1949

Variations for Blood Group, Lewis System

Expression for Blood Group, Lewis System

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