LW
MCID: BLD144
MIFTS: 13

Blood Group System, Landsteiner-Wiener (LW)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group System, Landsteiner-Wiener

MalaCards integrated aliases for Blood Group System, Landsteiner-Wiener:

Name: Blood Group System, Landsteiner-Wiener 57
Landsteiner-Wiener Blood Group System 57 6
Lw 57

Classifications:



External Ids:

OMIM® 57 111250

Summaries for Blood Group System, Landsteiner-Wiener

OMIM® : 57 The LW blood group antigens reside on a 42-kD red cell intercellular adhesion molecule designated ICAM4 (Bailly et al., 1994; Bailly et al., 1995). (111250) (Updated 20-May-2021)

MalaCards based summary : Blood Group System, Landsteiner-Wiener, is also known as landsteiner-wiener blood group system. An important gene associated with Blood Group System, Landsteiner-Wiener is ICAM4 (Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)). Related phenotype is Increased gamma-H2AX phosphorylation.

Related Diseases for Blood Group System, Landsteiner-Wiener

Symptoms & Phenotypes for Blood Group System, Landsteiner-Wiener

Clinical features from OMIM®:

111250 (Updated 20-May-2021)

GenomeRNAi Phenotypes related to Blood Group System, Landsteiner-Wiener according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 8.62 ICAM4 RPS19

Drugs & Therapeutics for Blood Group System, Landsteiner-Wiener

Search Clinical Trials , NIH Clinical Center for Blood Group System, Landsteiner-Wiener

Genetic Tests for Blood Group System, Landsteiner-Wiener

Anatomical Context for Blood Group System, Landsteiner-Wiener

Publications for Blood Group System, Landsteiner-Wiener

Articles related to Blood Group System, Landsteiner-Wiener:

# Title Authors PMID Year
1
Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes. 6 57
8639917 1996
2
Molecular basis and expression of the LWa/LWb blood group polymorphism. 6 57
7632968 1995
3
The red cell LW blood group protein is an intercellular adhesion molecule which binds to CD11/CD18 leukocyte integrins. 57
8566017 1995
4
The LW blood group glycoprotein is homologous to intercellular adhesion molecules. 57
8202485 1994
5
The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man. 57
2907851 1988
6
The LW:C3 recombination fraction in female meioses. 57
3120637 1987
7
Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci. 57
6431896 1984

Variations for Blood Group System, Landsteiner-Wiener

ClinVar genetic disease variations for Blood Group System, Landsteiner-Wiener:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ICAM4 ICAM4, 10-BP DEL, NT346 Deletion Affects 31099 GRCh37:
GRCh38:
2 ICAM4 NM_001544.5(ICAM4):c.299A>G (p.Gln100Arg) SNV Affects 17715 rs77493670 GRCh37: 19:10397987-10397987
GRCh38: 19:10287311-10287311
3 RPS19 NM_001022.4(RPS19):c.214G>T (p.Val72Phe) SNV Likely pathogenic 803562 rs1600621248 GRCh37: 19:42373142-42373142
GRCh38: 19:41869072-41869072

Expression for Blood Group System, Landsteiner-Wiener

Search GEO for disease gene expression data for Blood Group System, Landsteiner-Wiener.

Pathways for Blood Group System, Landsteiner-Wiener

GO Terms for Blood Group System, Landsteiner-Wiener

Sources for Blood Group System, Landsteiner-Wiener

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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