LW
MCID: BLD144
MIFTS: 21

Blood Group System, Landsteiner-Wiener (LW)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group System, Landsteiner-Wiener

MalaCards integrated aliases for Blood Group System, Landsteiner-Wiener:

Name: Blood Group System, Landsteiner-Wiener 58
Landsteiner-Wiener Blood Group System 58
Lw 58

Classifications:



External Ids:

OMIM 58 111250

Summaries for Blood Group System, Landsteiner-Wiener

OMIM : 58 The LW blood group antigens reside on a 42-kD red cell intercellular adhesion molecule designated ICAM4 (Bailly et al., 1994; Bailly et al., 1995). (111250)

MalaCards based summary : Blood Group System, Landsteiner-Wiener, also known as landsteiner-wiener blood group system, is related to epiphyseal dysplasia, microcephaly, and nystagmus and alzheimer disease. An important gene associated with Blood Group System, Landsteiner-Wiener is ICAM4 (Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)). Affiliated tissues include prostate, skin and breast.

Related Diseases for Blood Group System, Landsteiner-Wiener

Diseases related to Blood Group System, Landsteiner-Wiener via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 epiphyseal dysplasia, microcephaly, and nystagmus 11.4
2 alzheimer disease 10.2
3 leukemia 10.2
4 hemolytic anemia 10.1
5 pityriasis rubra pilaris 10.0
6 prostate cancer 10.0
7 immune deficiency disease 10.0
8 aging 10.0
9 prostate cancer, hereditary, 8 10.0
10 prostate cancer, hereditary, 6 10.0
11 diabetes mellitus 10.0
12 exocrine pancreatic insufficiency 10.0
13 thrombosis 10.0

Graphical network of the top 20 diseases related to Blood Group System, Landsteiner-Wiener:



Diseases related to Blood Group System, Landsteiner-Wiener

Symptoms & Phenotypes for Blood Group System, Landsteiner-Wiener

Clinical features from OMIM:

111250

Drugs & Therapeutics for Blood Group System, Landsteiner-Wiener

Search Clinical Trials , NIH Clinical Center for Blood Group System, Landsteiner-Wiener

Genetic Tests for Blood Group System, Landsteiner-Wiener

Anatomical Context for Blood Group System, Landsteiner-Wiener

MalaCards organs/tissues related to Blood Group System, Landsteiner-Wiener:

42
Prostate, Skin, Breast, Brain, Pancreas, Myeloid, Monocytes

Publications for Blood Group System, Landsteiner-Wiener

Articles related to Blood Group System, Landsteiner-Wiener:

(show top 50) (show all 93)
# Title Authors Year
1
Active fraction combination from Liuwei Dihuang decoction (LW-AFC) ameliorates corticosterone-induced long-term potentiation (LTP) impairment in mice in vivo. ( 30851370 )
2019
2
LW-215, a newly synthesized flavonoid, exhibits potent anti-angiogenic activity in vitro and in vivo. ( 29196258 )
2018
3
Evidence of glucuronidation of the glycation product LW-1: tentative structure and implications for the long-term complications of diabetes. ( 29305779 )
2018
4
LW-AFC, A New Formula Derived from Liuwei Dihuang Decoction, Ameliorates Cognitive Deterioration and Modulates Neuroendocrine-Immune System in SAMP8 Mouse. ( 27335033 )
2017
5
Selective cytotoxicity of microcystins LR, LW and LF in rat astrocytes. ( 27864109 )
2017
6
LW-AFC Effects on N-glycan Profile in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer's Disease. ( 28203484 )
2017
7
The Effects of LW-AFC on the Hippocampal Transcriptome in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer's Disease. ( 28222521 )
2017
8
LW-FQZip 2: a parallelized reference-based compression of FASTQ files. ( 28320326 )
2017
9
LW-213 induces G2/M cell cycle arrest through AKT/GSK3β/β-catenin signaling pathway in human breast cancer cells. ( 25945460 )
2016
10
Skin collagen fluorophore LW-1 versus skin fluorescence as markers for the long-term progression of subclinical macrovascular disease in type 1 diabetes. ( 26864236 )
2016
11
Commentary on: Saper CB, Loewy AD, Swanson LW, Cowan WM. (1976) Direct hypothalamo-autonomic connections. Brain Research 117:305-312. ( 26944298 )
2016
12
The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain. ( 27105505 )
2016
13
The Effects of LW-AFC on Intestinal Microbiome in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer's Disease. ( 27340848 )
2016
14
Quantitative determination by screening ELISA and HPLC-MS/MS of microcystins LR, LY, LA, YR, RR, LF, LW, and nodularin in the water of Occhito lake and crops. ( 27544518 )
2016
15
The role of cord blood BDNF in infant cognitive impairment induced by low-level prenatal manganese exposure: LW birth cohort, China. ( 27565312 )
2016
16
LW-AFC, a new formula derived from Liuwei Dihuang decoction, ameliorates behavioral and pathological deterioration via modulating the neuroendocrine-immune system in PrP-hAβPPswe/PS1ΔE9 transgenic mice. ( 27964740 )
2016
17
Gαs proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-αvβ3 and CD44-CD44 interactions. ( 26007235 )
2015
18
A comparison of faecal microbial populations of South African Windsnyer-type indigenous pigs (SAWIPs) and Large White × Landrace (LW × LR) crosses fed diets containing ensiled maize cobs. ( 26091682 )
2015
19
LW-214, a newly synthesized flavonoid, induces intrinsic apoptosis pathway by down-regulating Trx-1 in MCF-7 human breast cells. ( 24374359 )
2014
20
Commentary on "the E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity." Qi J, Tripathi M, Mishra R, Sahgal N, Fazli L, Ettinger S, Placzek WJ, Claps G, Chung LW, Bowtell D, Gleave M, Bhowmick N, Ronai ZA, Signal Transduction Program, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.: Cancer Cell 2013;23(6):332-46. ( 24445292 )
2014
21
Local classification: Locally weighted-partial least squares-discriminant analysis (LW-PLS-DA). ( 25064239 )
2014
22
Involvement of C/EBPβ in monocytic differentiation of acute myeloid leukemia cells induced by LW-218, a new synthesized flavonoid. ( 25150309 )
2014
23
Histological effects and localization of dissolved microcystins LR and LW in the mayfly Ecdyonurus angelieri Thomas (Insecta, Ephemeroptera). ( 25255731 )
2014
24
Occurrence of the microcystins MC-LW and MC-LF in Dutch surface waters and their contribution to total microcystin toxicity. ( 23880934 )
2013
25
Do not confuse anti-LW autoantibodies with anti-D. ( 23904811 )
2013
26
Cloning and bioinformatic analysis of an acidophilic beta-mannanase gene, Anman5A, from Aspergillus niger LW-1. ( 23101390 )
2012
27
Genetic and non-genetic parameters related to embryo production in superovulated Large White (LW) gilts. ( 22939008 )
2012
28
Cloning and functional expression of an acidophilic β-mannanase gene (Anman5A) from Aspergillus niger LW-1 in Pichia pastoris. ( 22225502 )
2012
29
The LW blood group system: a review. ( 22646069 )
2011
30
Comment on "Lw fecal elastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1 diabetes mellitus (pancreas. 2008;36:274-278)". ( 19390407 )
2009
31
Haemolytic disease of the foetus and newborn caused by auto anti-LW. ( 19706140 )
2009
32
Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. ( 17609430 )
2007
33
Influence of different diets on growth performance, meat quality, and disease resistance in pig crossbreeds (PIE x MC-local) and PIE (LW x MC-local). ( 17135567 )
2006
34
LW protein: a promiscuous integrin receptor activated by adrenergic signaling. ( 16564726 )
2006
35
Effectiveness of a perimenopausal health education intervention for mid-life women in northern Taiwan (#MS03-21-LW). ( 15324983 )
2004
36
Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions. ( 15308566 )
2004
37
Binding sites of leukocyte beta 2 integrins (LFA-1, Mac-1) on the human ICAM-4/LW blood group protein. ( 10846180 )
2000
38
Erythroid cell adhesion molecules Lutheran and LW in health and disease. ( 10895261 )
1999
39
Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes. ( 8639917 )
1996
40
LW/SO cell line: a tool for studying the phenotypical characterization and commitment of hematopoietic stem cells. ( 8645743 )
1996
41
Interaction between the sulfated lactobionic acid (LW 10082) and other antithrombotic agents in animal thrombosis model. ( 9112669 )
1996
42
Further issues in health promotion training. Re: Green LW. who will qualify to fill positions in health promotion? ( 7757895 )
1995
43
The red cell LW blood group protein is an intercellular adhesion molecule which binds to CD11/CD18 leukocyte integrins. ( 8566017 )
1995
44
Molecular basis and expression of the LWa/LWb blood group polymorphism. ( 7632968 )
1995
45
Molecular genetic basis of Rh and LW blood groups. ( 7526555 )
1994
46
The LW blood group glycoprotein is homologous to intercellular adhesion molecules. ( 8202485 )
1994
47
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats. ( 8157134 )
1993
48
Antithrombotic activities of aprosulate sodium (LW 10082) and its neutralization by protamine. ( 8362265 )
1993
49
Review: the LW blood group system. ( 15946068 )
1992
50
Interaction of the sulfated lactobionic acid amide LW 10082 with thrombin and its endogenous inhibitors. ( 1896968 )
1991

Variations for Blood Group System, Landsteiner-Wiener

ClinVar genetic disease variations for Blood Group System, Landsteiner-Wiener:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ICAM4 NM_001544.4(ICAM4): c.299A> G (p.Gln100Arg) single nucleotide variant Affects rs77493670 GRCh37 Chromosome 19, 10397987: 10397987
2 ICAM4 NM_001544.4(ICAM4): c.299A> G (p.Gln100Arg) single nucleotide variant Affects rs77493670 GRCh38 Chromosome 19, 10287311: 10287311
3 ICAM4 ICAM4, 10-BP DEL, NT346 deletion Affects

Expression for Blood Group System, Landsteiner-Wiener

Search GEO for disease gene expression data for Blood Group System, Landsteiner-Wiener.

Pathways for Blood Group System, Landsteiner-Wiener

GO Terms for Blood Group System, Landsteiner-Wiener

Sources for Blood Group System, Landsteiner-Wiener

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