VEL
MCID: BLD162
MIFTS: 23

Blood Group, Vel System (VEL)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Vel System

MalaCards integrated aliases for Blood Group, Vel System:

Name: Blood Group, Vel System 58
Blood Group System, Vel 41
Vel Blood Group System 6
Vel 58

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive

Miscellaneous:
clinical manifestations only occur if vel-negative individuals have anti-vel antibodies and are transfused with vel-positive blood
antibodies can develop after pregnancy or transfusion


HPO:

33
blood group, vel system:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 58 615264
MedGen 43 C2745907
SNOMED-CT via HPO 70 258211005

Summaries for Blood Group, Vel System

OMIM : 58 The Vel blood group system is defined by the presence of the Vel antigen on red blood cells. Vel is a high frequency antigen that shows variable strength, ranging from strong to weak. The rare Vel-negative blood type is inherited as an autosomal recessive trait and is typically unveiled when Vel-negative individuals develop anti-Vel antibodies after transfusion or pregnancy; Vel alloantibodies are never 'naturally occurring.' Individuals with anti-Vel antibodies may develop severe acute hemolytic transfusion reactions when transfused with Vel-positive blood. Individuals negative for the Vel antigen are rare and are required for the safe transfusion of patients with antibodies to Vel (summary by Daniels, 2002; Storry et al., 2013; Cvejic et al., 2013; Ballif et al., 2013). (615264)

MalaCards based summary : Blood Group, Vel System, also known as blood group system, vel, is related to myeloma, multiple and folliculitis. An important gene associated with Blood Group, Vel System is SMIM1 (Small Integral Membrane Protein 1 (Vel Blood Group)). Affiliated tissues include liver, bone and testes.

Related Diseases for Blood Group, Vel System

Diseases related to Blood Group, Vel System via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 myeloma, multiple 10.2
2 folliculitis 10.1
3 hydroa vacciniforme 10.1
4 quinquaud's decalvans folliculitis 10.1
5 blood group, langereis system 10.0
6 hypertension, essential 10.0
7 otitis media 10.0
8 anemia, autoimmune hemolytic 10.0
9 hepatitis c virus 10.0
10 microvascular complications of diabetes 5 10.0
11 blood group, junior system 10.0
12 hemolytic anemia 10.0
13 hepatitis 10.0
14 liver cirrhosis 10.0
15 endometritis 10.0
16 portal hypertension 10.0
17 ichthyosis 10.0
18 hepatitis c 10.0
19 elephantiasis 10.0
20 myotonia 10.0

Graphical network of the top 20 diseases related to Blood Group, Vel System:



Diseases related to Blood Group, Vel System

Symptoms & Phenotypes for Blood Group, Vel System

Symptoms via clinical synopsis from OMIM:

58
Hematology:
acute hemolytic transfusion reaction when transfused with vel-positive blood

Clinical features from OMIM:

615264

Drugs & Therapeutics for Blood Group, Vel System

Search Clinical Trials , NIH Clinical Center for Blood Group, Vel System

Genetic Tests for Blood Group, Vel System

Anatomical Context for Blood Group, Vel System

MalaCards organs/tissues related to Blood Group, Vel System:

42
Liver, Bone, Testes

Publications for Blood Group, Vel System

Articles related to Blood Group, Vel System:

(show top 50) (show all 78)
# Title Authors Year
1
SVR12 Higher than 97% in GT3 Cirrhotic Patients with Evidence of Portal Hypertension Treated with SOF/VEL without Ribavirin: A Nation-Wide Cohort Study. ( 30987413 )
2019
2
SMIM1 polymorphisms in a donor population from southeast Brazil and their correlation with VEL expression. ( 29517970 )
2019
3
Prevalence of SMIM1 c.64_80del17 homozygotes in southeastern Brazil: the Vel-negative phenotype. ( 30615815 )
2019
4
Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract. ( 30690691 )
2019
5
Development of a recombinant anti-Vel immunoglobulin M to identify Vel-negative donors. ( 30702752 )
2019
6
SMIM1 intron 2 gene variations leading to variability in Vel antigen expression among Brazilian blood donors. ( 30939337 )
2019
7
Clinical significance of antibodies to antigens in the Raph, John Milton Hagen, I, Globoside, Gill, Rh-associated glycoprotein, FORS, JR, LAN, Vel, CD59, and Augustine blood group systems. ( 30295501 )
2018
8
A SPECIAL MEETING REVIEW EDITION: Highlights in Hepatitis C Virus From the 2017 AASLD Liver Meeting: A Review of Selected Presentations From the 2017 AASLD Liver Meeting • October 20-24, 2017 • Washington, DCSpecial Reporting on:• Efficacy, Safety, and Pharmacokinetics of Glecaprevir/Pibrentasvir in Adults With Chronic Genotype 1-6 Hepatitis C Virus Infection and Compensated Cirrhosis: An Integrated Analysis• Hepatitis C Virus Reinfection and Injecting Risk Behavior Following Elbasvir/Grazoprevir Treatment in Participants on Opiate Agonist Therapy: Co-STAR Part B• Efficacy and Safety of Glecaprevir/Pibrentasvir for 8 or 12 Weeks in Treatment-Naive Patients With Chronic HCV Genotype 3: An Integrated Phase 2/3 Analysis• SOF/VEL/VOX for 12 Weeks in NS5A-Inhibitor-Experienced HCV-Infected Patients: Results of the Deferred Treatment Group in the Phase 3 POLARIS-1 Study• Adherence to Pangenotypic Glecaprevir/Pibrentasvir Treatment and SVR12 in HCV-Infected Patients: An Integrated Analysis of the Phase 2/3 Clinical Trial Program• The C-BREEZE 1 and 2 Studies: Efficacy and Safety of Ruzasvir Plus Uprifosbuvir for 12 Weeks in Adults With Chronic Hepatitis C Virus Genotype 1, 2, 3, 4, or 6 Infection100% SVR With 8 Weeks of Ledipasvir/Sofosbuvir in HIV-Infected Men With Acute HCV Infection: Results From the SWIFT-C Trial (Sofosbuvir-Containing Regimens Without Interferon for Treatment of Acute HCV in HIV-1-Infected Individuals)PLUS Meeting Abstract SummariesWith Expert Commentary by:Fred Poordad, MDChief, HepatologyUniversity Transplant CenterClinical Professor of MedicineThe University of Texas Health, San AntonioSan Antonio, Texas. ( 29950953 )
2017
9
SMIM1 variants rs1175550 and rs143702418 independently modulate Vel blood group antigen expression. ( 28084402 )
2017
10
A New Method for Land Vehicle Gravimetry Using SINS/VEL. ( 28375180 )
2017
11
The Vel blood group system: a review. ( 28657763 )
2017
12
Molecular screening of Vel-blood donors using DNA pools in Nanjing, China. ( 28881066 )
2017
13
Anti-Vel alloimmunization and severe hemolytic disease of the fetus and newborn. ( 29378146 )
2017
14
Characterization of a new human monoclonal antibody directed against the Vel antigen. ( 26382919 )
2016
15
High-throughput strategy for molecular identification of Vel- blood donors employing nucleic acids extracted from plasma pools used for viral nucleic acid test screening. ( 27060345 )
2016
16
Long-term results of the GIMEMA VEL-03-096 trial in MM patients receiving VTD consolidation after ASCT: MRD kinetics' impact on survival. ( 25027515 )
2015
17
Impact of genetic variation in the SMIM1 gene on Vel expression levels. ( 25647324 )
2015
18
SMIM1 is a type II transmembrane phosphoprotein and displays the Vel blood group antigen at its carboxyl-terminus. ( 26452714 )
2015
19
Molecular Screening for Vel- Blood Donors in Southwestern Germany. ( 26732700 )
2015
20
Pharmacokinetics and bone resorption evaluation of a novel Cathepsin K inhibitor (VEL-0230) in healthy adult horses. ( 24731241 )
2014
21
Disruption of SMIM1 causes the Vel- blood type. ( 23505126 )
2013
22
Homozygosity for a null allele of SMIM1 defines the Vel-negative blood group phenotype. ( 23563606 )
2013
23
SMIM1 underlies the Vel blood group and influences red blood cell traits. ( 23563608 )
2013
24
A comparison of bortezomib, cyclophosphamide, and dexamethasone (Vel-CD) chemotherapy without and with thalidomide (Vel-CTD) for the treatment of relapsed or refractory multiple myeloma. ( 22314843 )
2012
25
Leukocyte: tempus fugit vel carpe diem. ( 22741751 )
2012
26
Multidisciplinary approach to the treatment of a patient with chondrodystrophic myotonia (Schwartz-Jampel vel Aberfeld syndrome): case report and literature review. ( 21263291 )
2011
27
Clinical efficacy of a bortezomib, cyclophosphamide, thalidomide, and dexamethasone (Vel-CTD) regimen in patients with relapsed or refractory multiple myeloma: a phase II study. ( 19921192 )
2010
28
Role for serial prenatal anti-Vel quantitative serologic monitoring with 2-ME serum treatment during pregnancy: case report. ( 20795312 )
2010
29
Designer orthopaedic surgery in a patient with anti-Vel antibodies. ( 19409169 )
2009
30
Haemolytic disease of the newborn because of rare anti-Vel. ( 18598283 )
2008
31
Vel-donors in Yugoslavia. ( 15373697 )
2003
32
Anti-Vel reactivity diminished by adsorption with rabbit RBC stroma. ( 12430675 )
2002
33
Unsatisfactory detection of an in vivo haemolytic anti-vel by the gel test. ( 9745158 )
1998
34
Perspectives in beta 2-agonist therapy: vox clamantis in deserto vel lux in tenebris? ( 7897145 )
1995
35
Misidentification of anti-Vel due to inappropriate use of prewarming and adsorption techniques. ( 15945800 )
1994
36
Erythrocyte apheresis as a method for autologous blood transfusion--a case study in a patient with Vel-antibodies. ( 1600397 )
1992
37
Patients with anti-Vel--immunohematological characterization and transfusion management. ( 1703877 )
1990
38
Vel isoimmunization in pregnancy. ( 2327448 )
1990
39
An infant girl with severe autoimmune hemolytic anemia: apparent anti-Vel specificity. ( 3776136 )
1986
40
A human anti-Vel enhanced by sodium hypochlorite. ( 3705153 )
1986
41
A third example of haemolytic auto-anti-Vel. ( 6522937 )
1984
42
Lichen aureus vel purpuricus: report of a case. ( 6713723 )
1984
43
The second example of an anti-vel auto-antibody. ( 462905 )
1979
44
Red blood cell survival studies in patients with anti-Cha, anti-Yka, anti-Ge, and anti-Vel. ( 850935 )
1977
45
The Vel blood group in northern Sweden. ( 1007157 )
1976
46
Study of the alkaloid composition of Genista rumelica Vel. (first communication). ( 4629734 )
1972
47
The Vel blood group system. ( 5026468 )
1972
48
A case study of the detection and identification of anti-Vel within a family. ( 5089550 )
1971
49
An auto-antibody anti-Vel. ( 5094445 )
1971
50
Prenatal assessment of blood group antibodies against "public" antigens. An example of anti-Ve (Vel) in pregnancy. ( 4194411 )
1970

Variations for Blood Group, Vel System

ClinVar genetic disease variations for Blood Group, Vel System:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SMIM1 SMIM1, 17-BP DEL, NT64 deletion Affects

Expression for Blood Group, Vel System

Search GEO for disease gene expression data for Blood Group, Vel System.

Pathways for Blood Group, Vel System

GO Terms for Blood Group, Vel System

Sources for Blood Group, Vel System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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