VEL
MCID: BLD162
MIFTS: 14

Blood Group, Vel System (VEL)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Vel System

MalaCards integrated aliases for Blood Group, Vel System:

Name: Blood Group, Vel System 57
Blood Group System, Vel 40
Vel Blood Group System 6
Vel 57

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive

Miscellaneous:
clinical manifestations only occur if vel-negative individuals have anti-vel antibodies and are transfused with vel-positive blood
antibodies can develop after pregnancy or transfusion


HPO:

32
blood group, vel system:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 57 615264
MedGen 42 C2745907
SNOMED-CT via HPO 69 258211005

Summaries for Blood Group, Vel System

OMIM : 57 The Vel blood group system is defined by the presence of the Vel antigen on red blood cells. Vel is a high frequency antigen that shows variable strength, ranging from strong to weak. The rare Vel-negative blood type is inherited as an autosomal recessive trait and is typically unveiled when Vel-negative individuals develop anti-Vel antibodies after transfusion or pregnancy; Vel alloantibodies are never 'naturally occurring.' Individuals with anti-Vel antibodies may develop severe acute hemolytic transfusion reactions when transfused with Vel-positive blood. Individuals negative for the Vel antigen are rare and are required for the safe transfusion of patients with antibodies to Vel (summary by Daniels, 2002; Storry et al., 2013; Cvejic et al., 2013; Ballif et al., 2013). (615264)

MalaCards based summary : Blood Group, Vel System, also known as blood group system, vel, is related to myeloma, multiple and folliculitis. An important gene associated with Blood Group, Vel System is SMIM1 (Small Integral Membrane Protein 1 (Vel Blood Group)).

Related Diseases for Blood Group, Vel System

Diseases related to Blood Group, Vel System via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 myeloma, multiple 10.1
2 folliculitis 10.1
3 hydroa vacciniforme 10.1
4 quinquaud's decalvans folliculitis 10.1
5 anemia, autoimmune hemolytic 9.9
6 hepatitis c virus 9.9
7 hemolytic anemia 9.9
8 hepatitis 9.9
9 liver cirrhosis 9.9
10 endometritis 9.9
11 hepatitis c 9.9
12 elephantiasis 9.9
13 viral infectious disease 9.9
14 myotonia 9.9

Graphical network of the top 20 diseases related to Blood Group, Vel System:



Diseases related to Blood Group, Vel System

Symptoms & Phenotypes for Blood Group, Vel System

Symptoms via clinical synopsis from OMIM:

57
Hematology:
acute hemolytic transfusion reaction when transfused with vel-positive blood


Clinical features from OMIM:

615264

Drugs & Therapeutics for Blood Group, Vel System

Search Clinical Trials , NIH Clinical Center for Blood Group, Vel System

Genetic Tests for Blood Group, Vel System

Anatomical Context for Blood Group, Vel System

Publications for Blood Group, Vel System

Variations for Blood Group, Vel System

ClinVar genetic disease variations for Blood Group, Vel System:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SMIM1 SMIM1, 17-BP DEL, NT64 deletion Affects

Expression for Blood Group, Vel System

Search GEO for disease gene expression data for Blood Group, Vel System.

Pathways for Blood Group, Vel System

GO Terms for Blood Group, Vel System

Sources for Blood Group, Vel System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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