VEL
MCID: BLD162
MIFTS: 14

Blood Group, Vel System (VEL)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group, Vel System

MalaCards integrated aliases for Blood Group, Vel System:

Name: Blood Group, Vel System 58
Blood Group System, Vel 41
Vel Blood Group System 6
Vel 58

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive

Miscellaneous:
clinical manifestations only occur if vel-negative individuals have anti-vel antibodies and are transfused with vel-positive blood
antibodies can develop after pregnancy or transfusion


HPO:

33
blood group, vel system:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 58 615264
MedGen 43 C2745907
SNOMED-CT via HPO 70 258211005

Summaries for Blood Group, Vel System

OMIM : 58 The Vel blood group system is defined by the presence of the Vel antigen on red blood cells. Vel is a high frequency antigen that shows variable strength, ranging from strong to weak. The rare Vel-negative blood type is inherited as an autosomal recessive trait and is typically unveiled when Vel-negative individuals develop anti-Vel antibodies after transfusion or pregnancy; Vel alloantibodies are never 'naturally occurring.' Individuals with anti-Vel antibodies may develop severe acute hemolytic transfusion reactions when transfused with Vel-positive blood. Individuals negative for the Vel antigen are rare and are required for the safe transfusion of patients with antibodies to Vel (summary by Daniels, 2002; Storry et al., 2013; Cvejic et al., 2013; Ballif et al., 2013). (615264)

MalaCards based summary : Blood Group, Vel System, also known as blood group system, vel, is related to myeloma, multiple and folliculitis. An important gene associated with Blood Group, Vel System is SMIM1 (Small Integral Membrane Protein 1 (Vel Blood Group)).

Related Diseases for Blood Group, Vel System

Diseases related to Blood Group, Vel System via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 myeloma, multiple 10.1
2 folliculitis 10.1
3 hydroa vacciniforme 10.1
4 quinquaud's decalvans folliculitis 10.1
5 anemia, autoimmune hemolytic 10.0
6 hepatitis c virus 10.0
7 hemolytic anemia 10.0
8 hepatitis 10.0
9 liver cirrhosis 10.0
10 endometritis 10.0
11 ichthyosis 10.0
12 hepatitis c 10.0
13 elephantiasis 10.0
14 myotonia 10.0

Graphical network of the top 20 diseases related to Blood Group, Vel System:



Diseases related to Blood Group, Vel System

Symptoms & Phenotypes for Blood Group, Vel System

Symptoms via clinical synopsis from OMIM:

58
Hematology:
acute hemolytic transfusion reaction when transfused with vel-positive blood

Clinical features from OMIM:

615264

Drugs & Therapeutics for Blood Group, Vel System

Search Clinical Trials , NIH Clinical Center for Blood Group, Vel System

Genetic Tests for Blood Group, Vel System

Anatomical Context for Blood Group, Vel System

Publications for Blood Group, Vel System

Variations for Blood Group, Vel System

ClinVar genetic disease variations for Blood Group, Vel System:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SMIM1 SMIM1, 17-BP DEL, NT64 deletion Affects

Expression for Blood Group, Vel System

Search GEO for disease gene expression data for Blood Group, Vel System.

Pathways for Blood Group, Vel System

GO Terms for Blood Group, Vel System

Sources for Blood Group, Vel System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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