WR
MCID: BLD151
MIFTS: 15

Blood Group--Wright Antigen (WR)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group--Wright Antigen

MalaCards integrated aliases for Blood Group--Wright Antigen:

Name: Blood Group--Wright Antigen 57 29 6
Wright Blood Group Antigen 57
Wr 57

Classifications:



External Ids:

OMIM 57 112050
MedGen 42 C1862190

Summaries for Blood Group--Wright Antigen

OMIM : 57 The Wright antigen, a 'private' blood group (see 111500), was found by Holman (1953). Although it is very rare, the early date of its discovery and the ready availability of testing sera led to a large number of persons and variety of populations being tested. The frequency of the gene for the Wr(a) antigen was found to be about 3 in 10,000 among Europeans (Mourant et al., 1978). (112050)

MalaCards based summary : Blood Group--Wright Antigen, also known as wright blood group antigen, is related to epiphyseal dysplasia, multiple, with early-onset diabetes mellitus and progeroid syndrome, neonatal. An important gene associated with Blood Group--Wright Antigen is SLC4A1 (Solute Carrier Family 4 Member 1 (Diego Blood Group)). Affiliated tissues include testes and prostate.

Related Diseases for Blood Group--Wright Antigen

Diseases related to Blood Group--Wright Antigen via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 12.0
2 progeroid syndrome, neonatal 11.4
3 blood group, diego system 11.4
4 long qt syndrome 1 11.3
5 prostate cancer 10.2
6 spinal muscular atrophy 10.1
7 wrinkles 10.1
8 osteomyelitis 10.1
9 muscular atrophy 10.1
10 retinoblastoma 10.0
11 rheumatoid arthritis 10.0
12 malaria 10.0
13 cutaneous leishmaniasis 10.0
14 pemphigus foliaceus 10.0
15 plasmodium vivax malaria 10.0
16 leishmaniasis 10.0

Graphical network of the top 20 diseases related to Blood Group--Wright Antigen:



Diseases related to Blood Group--Wright Antigen

Symptoms & Phenotypes for Blood Group--Wright Antigen

Clinical features from OMIM:

112050

Drugs & Therapeutics for Blood Group--Wright Antigen

Search Clinical Trials , NIH Clinical Center for Blood Group--Wright Antigen

Genetic Tests for Blood Group--Wright Antigen

Genetic tests related to Blood Group--Wright Antigen:

# Genetic test Affiliating Genes
1 Blood Group--Wright Antigen 29 SLC4A1

Anatomical Context for Blood Group--Wright Antigen

MalaCards organs/tissues related to Blood Group--Wright Antigen:

41
Testes, Prostate

Publications for Blood Group--Wright Antigen

Variations for Blood Group--Wright Antigen

ClinVar genetic disease variations for Blood Group--Wright Antigen:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC4A1 NM_000342.3(SLC4A1): c.1972G> A (p.Glu658Lys) single nucleotide variant Affects rs75731670 GRCh37 Chromosome 17, 42331949: 42331949
2 SLC4A1 NM_000342.3(SLC4A1): c.1972G> A (p.Glu658Lys) single nucleotide variant Affects rs75731670 GRCh38 Chromosome 17, 44254581: 44254581

Expression for Blood Group--Wright Antigen

Search GEO for disease gene expression data for Blood Group--Wright Antigen.

Pathways for Blood Group--Wright Antigen

GO Terms for Blood Group--Wright Antigen

Sources for Blood Group--Wright Antigen

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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