WR
MCID: BLD151
MIFTS: 26

Blood Group--Wright Antigen (WR)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Blood Group--Wright Antigen

MalaCards integrated aliases for Blood Group--Wright Antigen:

Name: Blood Group--Wright Antigen 58 30 6
Wright Blood Group Antigen 58
Wr 58

Classifications:



External Ids:

OMIM 58 112050
MedGen 43 C1862190

Summaries for Blood Group--Wright Antigen

OMIM : 58 The Wright antigen, a 'private' blood group (see 111500), was found by Holman (1953). Although it is very rare, the early date of its discovery and the ready availability of testing sera led to a large number of persons and variety of populations being tested. The frequency of the gene for the Wr(a) antigen was found to be about 3 in 10,000 among Europeans (Mourant et al., 1978). (112050)

MalaCards based summary : Blood Group--Wright Antigen, also known as wright blood group antigen, is related to epiphyseal dysplasia, multiple, with early-onset diabetes mellitus and wiedemann-rautenstrauch syndrome. An important gene associated with Blood Group--Wright Antigen is SLC4A1 (Solute Carrier Family 4 Member 1 (Diego Blood Group)). Affiliated tissues include bone, liver and testes.

Related Diseases for Blood Group--Wright Antigen

Graphical network of the top 20 diseases related to Blood Group--Wright Antigen:



Diseases related to Blood Group--Wright Antigen

Symptoms & Phenotypes for Blood Group--Wright Antigen

Clinical features from OMIM:

112050

Drugs & Therapeutics for Blood Group--Wright Antigen

Search Clinical Trials , NIH Clinical Center for Blood Group--Wright Antigen

Genetic Tests for Blood Group--Wright Antigen

Genetic tests related to Blood Group--Wright Antigen:

# Genetic test Affiliating Genes
1 Blood Group--Wright Antigen 30 SLC4A1

Anatomical Context for Blood Group--Wright Antigen

MalaCards organs/tissues related to Blood Group--Wright Antigen:

42
Bone, Liver, Testes, Bone Marrow, Lung, Prostate, Skin

Publications for Blood Group--Wright Antigen

Articles related to Blood Group--Wright Antigen:

(show top 50) (show all 776)
# Title Authors Year
1
Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation. ( 30760738 )
2019
2
Response to letter to the editor re: Goldblatt LI, Adams WR, Spolnik KJ, Deardorf KA, Parks ET. Chronic fibrosing osteomyelitis of the jaws: An important cause of recalcitrant facial pain. A clinicopathologic study of 331 cases in 227 patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124:403-412. ( 29778440 )
2018
3
Letter to the Editor on Chronic fibrosing osteomyelitis of the jaws: an important cause of recalcitrant facial pain. A clinicopathologic study of 331 cases in 227 patients by Goldblatt LI, Adams WR, Spolnik KJ, Deardorf KA, Parks ET. ( 29748037 )
2018
4
Development of a Safe and Effective Vaccinia Virus Oncolytic Vector WR-Δ4 with a Set of Gene Deletions on Several Viral Pathways. ( 29367944 )
2018
5
Evaluation of a method for measuring the radioprotective metabolite WR-1065 in plasma using chemical derivatization combined with UHPLC-MS/MS. ( 29482122 )
2018
6
Interaction of the human erythrocyte Band 3 anion exchanger 1 (AE1, SLC4A1) with lipids and glycophorin A: Molecular organization of the Wright (Wr) blood group antigen. ( 30011272 )
2018
7
Pharmacological evaluation of Convolvulus pluricaulis as hypolipidaemic agent in Triton WR-1339-induced hyperlipidaemia in rats. ( 30182365 )
2018
8
Synthesis and in Vivo Lipid-Lowering Activity of Novel Imidazoles-5-carboxamide Derivatives in Triton-WR-1339-Induced Hyperlipidemic Wistar Rats. ( 30270241 )
2018
9
Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target. ( 28283022 )
2017
10
Enzymes that hydrolyze adenine nucleotides in a model of hypercholesterolemia induced by Triton WR-1339: protective effects of β-caryophyllene. ( 28432556 )
2017
11
The discovery of novel heat-stable keratinases from Meiothermus taiwanensis WR-220 and other extremophiles. ( 28680127 )
2017
12
Creating an enabling environment for WR&R implementation. ( 28953481 )
2017
13
Hypolipidemic activity of P-methoxycinnamic diester (PCO-C) isolated from Copernicia prunífera against Triton WR-1339 and hyperlipidemic diet in mice. ( 28961514 )
2017
14
Commentary on: "Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): A multicentre, randomised, double-blind, phase 3 trial." Kwon ED, Drake CG, Scher HI, Fizazi K, Bossi A, van den Eertwegh AJ, Krainer M, Houede N, Santos R, Mahammedi H, Ng S, Maio M, Franke FA, Sundar S, Agarwal N, Bergman AM, Ciuleanu TE, Korbenfeld E, Sengeløv L, Hansen S, Logothetis C, Beer TM, McHenry MB, Gagnier P, Liu D, Gerritsen WR, CA184-043 Investigators. Departments of Urology and Immunology and Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, MN, USA, Electronic address: kwon.eugene@mayo.edu; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center and Brady Urological Institute, Baltimore, MD, USA; Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA; Institut Gustave Roussy, University of Paris-Sud, Villejuif, France; Institut Gustave Roussy, Villejuif, France; VU University Medical Centre, Amsterdam, Netherlands; Vienna General Hospital, Medical University Vienna, Vienna, Austria; Institut Bergonié, Bordeaux, France; CHU Caremeau, Nimes, France; Centro Médico Austral, Buenos Aires, Argentina; Centre Jean Perrin, Clermont-Ferrand, France; St John of God Hospital, Subiaco, WA, Australia; University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy; Hospital de Caridade de Ijuí, Ijuí, Brazil; Nottingham University Hospital, Nottingham, UK; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Netherlands Cancer Institute and Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands; Institute of Oncology Ion Chiricuta and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania; Hospital Británico de Buenos Aires, Buenos Aires, Argentina; Herlev Hospital, Herlev, Denmark; Odense University Hospital, Odense, Denmark; University of Texas MD Anderson Cancer Center, Houston, ( 25907621 )
2016
15
Evaluation of hypolipidemic Marrubium vulgare effect in Triton WR-1339-induced hyperlipidemia in mice. ( 27261853 )
2016
16
Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats. ( 27403255 )
2016
17
Lipid lowering activity of novel N-(benzoylphenyl)pyridine-3-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats. ( 27558168 )
2016
18
Volatile organic compounds produced by Pseudomonas fluorescens WR-1 restrict the growth and virulence traits of Ralstonia solanacearum. ( 27664728 )
2016
19
Shreiner DP, Bell WR. Pseudothrombocytopenia: manifestation of a new type of platelet agglutinin. Blood. 1973;42(4):541-549. ( 27737843 )
2016
20
Erratum to: Baumann BC, Bosch WR, Bahl A, et al. Development and validation of consensus contouring guidelines for adjuvant radiation therapy for bladder cancer after radical cystectomy. Int J Radiat Oncol Biol Phys 2016;96:78-86. ( 27869092 )
2016
21
"WR". ( 28289505 )
2016
22
Re: M-A Fitzcharles, PA Ste-Marie, A Mailis, Y Shir. Re: Harth M, Neilson WR. Fibromyalgia and disability adjudication: No simple solutions to a complex problem. Pain Res Manag 2014;19(6):293-299. ( 25664541 )
2015
23
The dipeptide H-Trp-Arg-OH (WR) Is a PPARα agonist and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells. ( 25377249 )
2015
24
Radioprotector WR-2721 and mitigating peptidoglycan synergistically promote mouse survival through the amelioration of intestinal and bone marrow damage. ( 25617317 )
2015
25
Erratum to: Melidis C, Bosch WR, Izewska J, et al. Global harmonization of quality assurance naming conventions in radiation therapy Clinical Trials. Int J Radiat Oncol Biol Phys 2014;90:1242-1249. ( 25832708 )
2015
26
Radioprotective effects of Sipunculus nudus L. polysaccharide combined with WR-2721, rhIL-11 and rhG-CSF on radiation-injured mice. ( 25852150 )
2015
27
Contribution of occupational health for prevention of work-related cardiovascular disorders (WR-CVDS). ( 26159940 )
2015
28
Frequency of Wr(a) antigen and anti-Wr(a) in Brazilian blood donors. ( 26408365 )
2015
29
Re: Chamberland S, Proffit WR, Chamberland PE. Functional Genioplasty in growing patients. Angle Orthod. 2015;85:360-373. ( 26516715 )
2015
30
Re: response to: functional genioplasty in growing patients by Chamberland S, Proffit WR, Chamberland PE. Angle Orthod. 2015; 85:360-373. ( 26516716 )
2015
31
Development and Validation of an HPLC Method for Determination of Amifostine and/or Its Metabolite (WR-1065) In Human Plasma Using OPA Derivatization and UV Detection. ( 26664371 )
2015
32
Navifocus WR is the promising intravascular ultrasound for navigating the guidewire into true lumen during the coronary intervention for chronic total occlusion. ( 24101093 )
2014
33
Re: Peltz TS, Haddad R, Scougall PJ, Gianoutsos MP, Bertollo N, Walsh WR. Performance of a knotless four-strand flexor tendon repair with a unidirectional barbed suture device: a dynamic ex vivo comparison. J Hand Surg Eur. 2014, 39: 30-39. ( 24366924 )
2014
34
Commentary on "identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array." Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Ghoussaini M, Luccarini C, Dennis J, Jugurnauth-Little S, Dadaev T, Neal DE, Hamdy FC, Donovan JL, Muir K, Giles GG, Severi G, Wiklund F, Gronberg H, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock SJ, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Canzian F, Riboli E, Key TJ, Travis RC, Campa D, Ingles SA, John EM, Hayes RB, Pharoah PD, Pashayan N, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Vogel W, Kibel AS, Cybulski C, Lubinski J, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Spurdle AB, Clements JA, Teixeira MR, Dicks E, Lee A, Dunning AM, Baynes C, Conroy D, Maranian MJ, Ahmed S, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As NJ, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatananon A, Cox A, Southey MC, Hopper JL, English DR, Aly M, Adolfsson J, Xu J, Zheng SL, Yeager M, Kaaks R, Diver WR, Gaudet MM, Stern MC, Corral R, Joshi AD, Shahabi A, Wahlfors T, Tammela TL, Auvinen A, Virtamo J, Klarskov P, Nordestgaard BG, Røder MA, Nielsen SF, Bojesen SE, Siddiq A, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Blot WJ, Zheng W, Cai Q, McDonnell SK, Rinckleb AE, Drake B, Colditz G, Wokolorczyk D, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Sellers TA, Lin HY, Slavov C, Mitev V, Lose F, Srinivasan S, Maia S, Paulo P, Lange E, Cooney KA, Antoniou AC, Vincent D, Bacot F, Tessier DC; COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative; Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; UK ProtecT (Prostate testing for cancer and Treatment) Study ( 24445293 )
2014
35
Commentary on "common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer." Garcia-Closas M, Rothman N, Figueroa JD, Prokunina-Olsson L, Han SS, Baris D, Jacobs EJ, Malats N, De Vivo I, Albanes D, Purdue MP, Sharma S, Fu YP, Kogevinas M, Wang Z, Tang W, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G Jr., Grubb R 3rd, Black A, Gapstur SM, Thun M, Diver WR, Weinstein SJ, Virtamo J, Hunter DJ, Caporaso N, Landi MT, Hutchinson A, Burdett L, Jacobs KB, Yeager M, Fraumeni JF Jr., Chanock SJ, Silverman DT, Chatterjee N, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.: Cancer Res 2013;73(7):2211-20 [Epub 2013 Mar 27]. ( 24445297 )
2014
36
Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent. ( 24459009 )
2014
37
Antihypercholesterolemic and Antioxidative Potential of an Extract of the Plant, Piper betle, and Its Active Constituent, Eugenol, in Triton WR-1339-Induced Hypercholesterolemia in Experimental Rats. ( 24523820 )
2014
38
Hypolipidemic activity of Phellinus rimosus against triton WR-1339 and high cholesterol diet induced hyperlipidemic rats. ( 24561532 )
2014
39
Selective protection of zidovudine-induced DNA-damage by the antioxidants WR-1065 and tempol. ( 24833597 )
2014
40
WR (Bill) Paisley - an old country "doc". ( 25082996 )
2014
41
Polymer complex of WR 2721. Synthesis and radioprotective efficiency. ( 25159838 )
2014
42
Protection of Saururus Chinensis Extract against Liver Oxidative Stress in Rats of Triton WR-1339-induced Hyperlipidemia. ( 25584149 )
2014
43
Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice. ( 23001493 )
2014
44
Re: Harth M, Neilson WR. Fibromyalgia and disability adjudication: no simple solutions to a complex problem. Pain Res Manag 2014;19(6):293-299. ( 25479150 )
2014
45
Hypolipidemic action of chrysin on Triton WR-1339-induced hyperlipidemia in female C57BL/6 mice. ( 28962239 )
2014
46
Feasibility study of the pharmacology of local application of amifostine (WR-2721) to the buccal mucosa in guinea pigs. ( 23736649 )
2013
47
In vitro antioxidant and antihyperlipidemic activities of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet induced hyperlipidemic rats. ( 23891761 )
2013
48
Comparative characteristics of lipemia models induced by injections of Triton WR-1339 and poloxamer 407 in mice. ( 24131010 )
2013
49
Commentary on "Abiraterone in metastatic prostate cancer without previous chemotherapy." Ryan CJ, Smith MR, de Bono JS, Molina A, Logothetis CJ, de Souza P, Fizazi K, Mainwaring P, Piulats JM, Ng S, Carles J, Mulders PF, Basch E, Small EJ, Saad F, Schrijvers D, Van Poppel H, Mukherjee SD, Suttmann H, Gerritsen WR, Flaig TW, George DJ, Yu EY, Efstathiou E, Pantuck A, Winquist E, Higano CS, Taplin ME, Park Y, Kheoh T, Griffin T, Scher HI, Rathkopf DE; COU-AA-302 Investigators, Genitourinary Medical Oncology Program, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA. N Engl J Med 2013;368(2):138-48 [Epub 2012 Dec 10]; N Engl J Med 2013;368(6):584. ( 24210085 )
2013
50
The hypolipidemic activity of Ayurvedic medicine, Arogyavardhini vati in Triton WR-1339-induced hyperlipidemic rats: A comparison with fenofibrate. ( 24250146 )
2013

Variations for Blood Group--Wright Antigen

ClinVar genetic disease variations for Blood Group--Wright Antigen:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC4A1 NM_000342.3(SLC4A1): c.1972G> A (p.Glu658Lys) single nucleotide variant Affects rs75731670 GRCh37 Chromosome 17, 42331949: 42331949
2 SLC4A1 NM_000342.3(SLC4A1): c.1972G> A (p.Glu658Lys) single nucleotide variant Affects rs75731670 GRCh38 Chromosome 17, 44254581: 44254581
3 SLC4A1 NM_000342.3(SLC4A1): c.1765C> T (p.Arg589Cys) single nucleotide variant Pathogenic rs121912745 GRCh37 Chromosome 17, 42333076: 42333076
4 SLC4A1 NM_000342.3(SLC4A1): c.1765C> T (p.Arg589Cys) single nucleotide variant Pathogenic rs121912745 GRCh38 Chromosome 17, 44255708: 44255708

Expression for Blood Group--Wright Antigen

Search GEO for disease gene expression data for Blood Group--Wright Antigen.

Pathways for Blood Group--Wright Antigen

GO Terms for Blood Group--Wright Antigen

Sources for Blood Group--Wright Antigen

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