MCID: BLD054
MIFTS: 38

Blood Protein Disease

Categories: Blood diseases

Aliases & Classifications for Blood Protein Disease

MalaCards integrated aliases for Blood Protein Disease:

Name: Blood Protein Disease 12 15 71
Blood Protein Disorders 43 71
Blood Protein Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:620
MeSH 43 D001796
UMLS 71 C0005830 C4020764

Summaries for Blood Protein Disease

MalaCards based summary : Blood Protein Disease, also known as blood protein disorders, is related to poems syndrome and sickle cell anemia. An important gene associated with Blood Protein Disease is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Allograft rejection. The drugs Denosumab and Zoledronic Acid have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related phenotype is hematopoietic system.

Wikipedia : 74 Blood proteins, also termed plasma proteins, are proteins present in blood plasma. They serve many... more...

Related Diseases for Blood Protein Disease

Diseases related to Blood Protein Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 337)
# Related Disease Score Top Affiliating Genes
1 poems syndrome 32.3 VEGFA MYOM2 IL6
2 sickle cell anemia 32.0 MTHFR IL6 HBB F2 CD40LG BCL11A
3 monoclonal gammopathy of uncertain significance 31.3 SDC1 NSD2 MYOM2 MIR19A MIR126 MAG
4 syphilis 30.3 IL6 F2 CD40LG B2M
5 plasmacytoma 30.2 VEGFA IL6 CD38 B2M
6 endocarditis 30.2 SERPINC1 IL6 F2
7 purpura 30.2 SERPINC1 PROS1 IL6 F2 CD40LG
8 peripheral nervous system disease 29.7 VEGFA MYOM2 MIR126 MAG IL6 ICOSLG
9 orbital osteomyelitis 10.7 HBB F2
10 arteritic anterior ischemic optic neuropathy 10.7 MTHFR F2
11 hereditary persistence of fetal hemoglobin-sickle cell disease syndrome 10.7 HBB BCL11A
12 heparin-induced thrombocytopenia 10.7 SERPINC1 CD40LG
13 fournier gangrene 10.7 SERPINC1 F2 CD40LG
14 retroperitoneal lymphoma 10.7 F2 CD40LG
15 splenic sequestration 10.7 HBB F2 CD40LG
16 monoclonal paraproteinemia 10.7 SDC1 IGHV4-38-2 CD40LG
17 gamma heavy chain disease 10.7 SDC1 IGHV4-38-2 CD40LG
18 bronchiectasis 2 10.7 VEGFA B2M
19 blue toe syndrome 10.7 SERPINC1 F2
20 prothrombin-related thrombophilia 10.7 MTHFR F2
21 macroglobulinemia 10.7 SDC1 IL6 CD40LG
22 pleural empyema 10.7 SDC1 F2 CD40LG
23 amyloid tumor 10.7 MYOM2 B2M
24 asymmetric motor neuropathy 10.7 MYOM2 MAG CD40LG
25 vitamin k deficiency bleeding 10.7 SERPINC1 PROS1 F2
26 mononeuritis of upper limb and mononeuritis multiplex 10.7 MYOM2 MAG CD40LG
27 mononeuritis multiplex 10.7 MYOM2 MAG CD40LG
28 streptococcal toxic-shock syndrome 10.7 MYOM2 IL6
29 miller fisher syndrome 10.7 MYOM2 MAG CD40LG
30 polyclonal hypergammaglobulinemia 10.7 MYOM2 IL6 CD40LG
31 mononeuropathy 10.7 MYOM2 MAG CD40LG
32 purpura fulminans 10.7 SERPINC1 PROS1 F2
33 spinal cord infarction 10.7 SERPINC1 MTHFR F2
34 mental retardation, autosomal dominant 10 10.7 SDC1 IGHV4-38-2 CD38
35 giant hemangioma 10.7 SERPINC1 F2
36 erysipelas 10.7 MYOM2 IL6 CD40LG
37 lateral sinus thrombosis 10.7 SERPINC1 MTHFR F2
38 dic in newborn 10.7 SERPINC1 F2
39 hemoglobin e disease 10.7 HBE1 HBB F2
40 lemierre's syndrome 10.7 SERPINC1 MTHFR F2
41 livedoid vasculitis 10.7 SERPINC1 MTHFR F2
42 impetigo 10.7 MYOM2 IL6 CD40LG
43 intracranial sinus thrombosis 10.7 SERPINC1 MTHFR F2
44 primary thrombocytopenia 10.7 ICOSLG F2 CD40LG
45 post-thrombotic syndrome 10.7 SERPINC1 IL6 F2
46 danubian endemic familial nephropathy 10.7 F2 CD40LG B2M
47 immunodeficiency with hyper-igm, type 2 10.7 IGHV4-38-2 ICOSLG CD40LG
48 waterhouse-friderichsen syndrome 10.6 SERPINC1 F2
49 compartment syndrome 10.6 SERPINC1 IL6 F2
50 cavernous sinus thrombosis 10.6 SERPINC1 F2

Graphical network of the top 20 diseases related to Blood Protein Disease:



Diseases related to Blood Protein Disease

Symptoms & Phenotypes for Blood Protein Disease

MGI Mouse Phenotypes related to Blood Protein Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.36 B2M BCL11A CD38 CD40LG F2 IL6

Drugs & Therapeutics for Blood Protein Disease

Drugs for Blood Protein Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 3 615258-40-7
2
Zoledronic Acid Approved Phase 3 118072-93-8 68740
3
Bortezomib Approved, Investigational Phase 3 179324-69-7 387447 93860
4
Vorinostat Approved, Investigational Phase 3 149647-78-9 5311
5 Histone Deacetylase Inhibitors Phase 3
6 Anti-Inflammatory Agents Phase 3
7 Diphosphonates Phase 3
8 Hemostatics Phase 3
9 Analgesics, Non-Narcotic Phase 3
10 Analgesics Phase 3
11 Antirheumatic Agents Phase 3
12 Anti-Inflammatory Agents, Non-Steroidal Phase 3
13
Zanubrutinib Approved, Investigational Phase 1, Phase 2 1691249-45-2
14
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1, Phase 2 1177-87-3
15
Dexamethasone Approved, Investigational, Vet_approved Phase 1, Phase 2 50-02-2 5743
16
Tyrosine Approved, Investigational, Nutraceutical Phase 1, Phase 2 60-18-4 6057
17 Ricolinostat Investigational Phase 1, Phase 2 1316214-52-4
18 rifamycin SV Phase 1, Phase 2
19 Rifamycins Phase 1, Phase 2
20 Gastrointestinal Agents Phase 1, Phase 2
21 Hormones Phase 1, Phase 2
22
protease inhibitors Phase 1, Phase 2
23 Antineoplastic Agents, Hormonal Phase 1, Phase 2
24 Hormone Antagonists Phase 1, Phase 2
25 Antiemetics Phase 1, Phase 2
26 HIV Protease Inhibitors Phase 1, Phase 2
27 BB 1101 Phase 1, Phase 2
28 glucocorticoids Phase 1, Phase 2
29 Immunoglobulins Phase 1
30 Protein Kinase Inhibitors Phase 1
31
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
32 Antibodies Phase 1
33 Antibodies, Monoclonal Phase 1

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Multicenter Study of Denosumab Compared With Zoledronic Acid in the Treatment of Bone Disease in Subjects With Newly Diagnosed Multiple Myeloma Completed NCT01345019 Phase 3 Denosumab;Zoledronic acid;Placebo to Denosumab;Placebo to zoledronic acid;Denosumab (for the open-label treatment phase)
2 An International, Multicenter, Randomized, Double-Blind Study of Vorinostat (MK0683) or Placebo in Combination With Bortezomib in Patients With Multiple Myeloma Completed NCT00773747 Phase 3 vorinostat;bortezomib;placebo to vorinostat
3 Phase 3b, Randomized Trial of Continuous Revlimid® (Lenalidomide) Therapy Versus Observation Following Induction Therapy That Does Not Include Revlimid, Pomalyst® or Thalomid® in Newly Diagnosed Multiple Myeloma Withdrawn NCT02155634 Phase 3 Lenalidomide
4 Phase 1/2 Open-Label, Multiple-Dose, Dose-Escalation Study to Evaluate the Safety and Tolerability of SNS01-T Administered by Intravenous Infusion in Patients With Relapsed or Refractory B Cell Malignancies Unknown status NCT01435720 Phase 1, Phase 2
5 An Open Label, Dose Escalation, Multicenter Phase 1/2 Study of KW-2478 in Combination With Bortezomib in Subjects With Relapsed and/or Refractory Multiple Myeloma Completed NCT01063907 Phase 1, Phase 2 KW-2478;Bortezomib
6 A Phase I/II Open-label Multicenter Study of AT7519M Alone and in Combination With Bortezomib in Patients With Previously Treated Multiple Myeloma Completed NCT01183949 Phase 1, Phase 2 AT7519M;Bortezomib
7 A Phase I/II Study of Human Placental Hematopoietic Stem Cell Derived Natural Killer Cells (CYNK 001) in Multiple Myeloma Patients Following Autologous Stem Cell Transplant in the Front-line Setting. Recruiting NCT04309084 Phase 1, Phase 2
8 A Phase 1/2 Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ARQ 531 in Selected Subjects With Relapsed or Refractory Hematologic Malignancies Recruiting NCT03162536 Phase 1, Phase 2 ARQ 531;ARQ 531
9 A Phase 1B/2 Multi-Center, Open Label, Dose-Escalation Study to Determine the Maximum Tolerated Dose, Safety, and Efficacy of ACY-1215 (RICOLINOSTAT) in Combination With Pomalidomide and Low-Dose Dexamethasone in Patients With Relapsed and Refractory Multiple Myeloma Active, not recruiting NCT01997840 Phase 1, Phase 2 ACY-1215 (Ricolinostat) in combination with pomalidomide and dexamethasone
10 A Phase 1 Study of AV-299 (Formerly SCH 900105) Administered by IV Infusion as Monotherapy in Advanced Solid Tumors, Lymphomas, or Multiple Myeloma or in Combination With Erlotinib in Advanced Solid Tumors Completed NCT00725634 Phase 1
11 Bedside Assessment of Coagulation in Post-partum Hemorrhage by Thromboelastography (TEG ®6S) Unknown status NCT03592303
12 Project 2 (Mayo): Transfusion-Induced Alterations of Pulmonary and Immune Function in Mechanically Ventilated Patients Completed NCT00751322

Search NIH Clinical Center for Blood Protein Disease

Cochrane evidence based reviews: blood protein disorders

Genetic Tests for Blood Protein Disease

Anatomical Context for Blood Protein Disease

MalaCards organs/tissues related to Blood Protein Disease:

40
Liver, Bone, Testes, B Cells, Bone Marrow, Heart, Kidney

Publications for Blood Protein Disease

Articles related to Blood Protein Disease:

(show top 50) (show all 82)
# Title Authors PMID Year
1
[Blood protein disorders in the course of acute and chronic osteomyelitis in children and the role of protein therapy in their compensation]. 61
606015 1977
2
[Blood protein disorders in collagen diseases. Experiences on 4 cases studied by simple electrophoresis, immunoelectrophoresis and electrophoretic immunoquantification]. 61
5003416 1971
3
[Congenital and acquired blood protein disorders]. 61
5156863 1971
4
[Therapy of blood protein disorders]. 61
4990207 1970
5
[Bovine gamma globulin in rectal administration in the therapy of blood protein disorders]. 61
4192807 1970
6
[Relation between occupation and frequency of blood protein disorders]. 61
5447228 1970
7
[Diagnostic method for blood protein disorders]. 61
4185052 1969
8
[Current studies on electron microscopic leukocyte morphology. Microstructure of the cells in blood protein disorders]. 61
4897034 1969
9
[Blood protein disorders]. 61
4178409 1968
10
[Blood protein disorders in chronic liver diseases: "direct" and "indirect" liver function tests]. 61
5709937 1968
11
[Determination of digitalemia and its relation to the cardiokinetic effect in patients with blood protein disorders]. 61
5717509 1968
12
[Column gel-filtration. Possibilities of use in the diagnosis of blood protein disorders]. 61
5747755 1968
13
[A new test for blood protein disorders]. 61
4185151 1967
14
[The Jones and Thompson test in the diagnosis of blood protein disorders. (Study of the reaction in relation to the serum immunoglobulin level)]. 61
4176301 1967
15
[Dysprotidemic blood protein disorders with paraproteinemia and skeletal diseases]. 61
5963958 1966
16
[Influence of blood protein disorders on the mechanism of experimental hepatic regeneration]. 61
5908186 1966
17
[Blood protein disorders in various internal diseases]. 61
5899212 1965
18
[Immunochemical study on blood protein disorders]. 61
5895144 1965
19
[Anti-liver antibodies in the blood of children affected by liver diseases and by various blood protein disorders]. 61
5849548 1965
20
[Limitations of immunoelectrophoresis in the diagnosis of blood protein disorders]. 61
4961497 1965
21
[TECHNICAL AND METHODOLOGICAL LIMITATIONS IN THE EVALUATION OF BLOOD PROTEIN DISORDERS]. 61
14269262 1964
22
[LYMPHADENOPATHIES AND BLOOD PROTEIN DISORDERS OR MEDICINAL ORIGIN, SIMULATING A MALIGNANT DISEASE]. 61
14304669 1964
23
[CONTRIBUTION OF THE LABORATORY IN THE DIAGNOSIS OF BLOOD PROTEIN DISORDERS]. 61
14111278 1964
24
[BLOOD PROTEIN DISORDERS IN SOME KIDNEY DISEASES IN CHILDREN]. 61
14157294 1964
25
[THE PHYSIOPATHOLOGY OF BLOOD PROTEIN DISORDERS]. 61
14111275 1964
26
[THE BLOOD PROTEIN DISORDERS: CLINICAL ASPECTS]. 61
14111276 1964
27
[PATHOPHYSIOLOGY OF BLOOD PROTEIN DISORDERS AND GENESIS OF PROTEINS IN DIABETIC ANGIOPATHY. 5. THE PLACE OF THE INTERRENAL SYSTEM AND FUNCTION OF ANABOLIC STEROIDS IN THE DIABETIC-ANGIOPATHIC SERUM PROTEIN METABOLISM]. 61
14093648 1963
28
[THE LUNG IN BLOOD DISEASES, RETICULOSIS AND BLOOD PROTEIN DISORDERS]. 61
14092744 1963
29
[Congenital heart diseases and blood protein disorders (study of 40 cases)]. 61
13983228 1962
30
[Study of blood protein disorders in the colitis-hypochlorhydria syndrome]. 61
14495292 1962
31
[Flocculation tests in liver diseases and blood protein disorders]. 61
13770540 1961
32
[Purpura caused by blood protein disorders. Benign hyperglobulinemic purpura with]. 61
13831200 1961
33
[Blood protein disorders in a rabbit infested with Fasciola hepatica. Electrophoretic study]. 61
13749559 1960
34
[Research on the ironbinding function of the blood in patients with blood protein disorders]. 61
13689953 1960
35
[Therapeutic trends in apparently primary blood protein disorders]. 61
13689770 1960
36
[Turbidimetric determination of gamma globulins in the course of blood protein disorders]. 61
13689237 1960
37
[Considerations on the interpretation of tests of blood protein disorders and the electrophoretic spectrum in liver diseases]. 61
14410967 1960
38
[Apropos of some cases of blood protein disorders]. 61
13687175 1960
39
[Study of blood protein disorders]. 61
14421178 1960
40
[The ocular signs of blood protein disorders]. 61
14430971 1959
41
[Relations between erythrocyte clumping & blood protein disorders; clinical & experimental study]. 61
13670734 1959
42
[Significance of blood protein disorders in evaluation of indications for radical surgical intervention in osteoarticular tuberculosis]. 61
13647868 1959
43
[Blood protein disorders induced by injection of various corticosteroids in rat]. 61
13606967 1958
44
[Blood protein disorders in children with burns as a prognostic index]. 61
13624259 1958
45
[Blood protein disorders plasmacytoma; differences in the results of different methods of protein analysis]. 61
13554903 1958
46
[Blood protein disorders]. 61
13574533 1958
47
[The effect of acute hypoxemia on the course of experimental inflammation and blood protein disorders]. 61
13612247 1958
48
[Study of blood protein disorders in cancer patients]. 61
13519562 1957
49
[Use of the Cohn method of fractionation in clinical medicine for analysis of the protein fractions of the sera of normal subjects and those with blood protein disorders]. 61
13499024 1957
50
[Behavior of plasma protein-bound iodine following thyroxin administration in patients with blood protein disorders]. 61
13461955 1957

Variations for Blood Protein Disease

Expression for Blood Protein Disease

Search GEO for disease gene expression data for Blood Protein Disease.

Pathways for Blood Protein Disease

GO Terms for Blood Protein Disease

Cellular components related to Blood Protein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 VEGFA SERPINC1 SDC1 PROS1 IL6 HBB
2 extracellular exosome GO:0070062 9.91 SERPINC1 SDC1 PROS1 MIR19A ICOSLG HBB
3 extracellular space GO:0005615 9.65 VEGFA SERPINC1 PROS1 MIR19A MIR126 IL6
4 external side of plasma membrane GO:0009897 9.63 SDC1 IGHV4-38-2 ICOSLG F2 CD40LG B2M
5 hemoglobin complex GO:0005833 9.4 HBE1 HBB
6 haptoglobin-hemoglobin complex GO:0031838 9.32 HBE1 HBB
7 blood microparticle GO:0072562 9.02 SERPINC1 PROS1 HBE1 HBB F2

Biological processes related to Blood Protein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.85 VEGFA MIR19A IL6 CD40LG CD38
2 cellular protein metabolic process GO:0044267 9.67 SERPINC1 IL6 F2 B2M
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.5 VEGFA MIR19A IL6
4 leukocyte migration GO:0050900 9.46 SDC1 PROS1 MAG F2
5 regulation of blood coagulation GO:0030193 9.43 SERPINC1 F2
6 negative regulation of neuron projection development GO:0010977 9.43 MAG CD38 B2M
7 cardiac muscle fiber development GO:0048739 9.4 VEGFA MYOM2
8 hemostasis GO:0007599 9.13 SERPINC1 PROS1 F2
9 blood coagulation GO:0007596 9.02 SERPINC1 PROS1 HBE1 HBB F2

Molecular functions related to Blood Protein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organic acid binding GO:0043177 9.16 HBE1 HBB
2 haptoglobin binding GO:0031720 8.96 HBE1 HBB
3 hemoglobin alpha binding GO:0031721 8.62 HBE1 HBB

Sources for Blood Protein Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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