MCID: BLD054
MIFTS: 33

Blood Protein Disease

Categories: Blood diseases

Aliases & Classifications for Blood Protein Disease

MalaCards integrated aliases for Blood Protein Disease:

Name: Blood Protein Disease 12 15 71
Blood Protein Disorders 44 71
Blood Protein Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:620
MeSH 44 D001796
UMLS 71 C0005830 C4020764

Summaries for Blood Protein Disease

MalaCards based summary : Blood Protein Disease, also known as blood protein disorders, is related to sickle cell anemia and monoclonal gammopathy of uncertain significance. An important gene associated with Blood Protein Disease is MIR19A (MicroRNA 19a), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drug Hemostatics has been mentioned in the context of this disorder. Affiliated tissues include liver and bone marrow.

Wikipedia : 74 Blood proteins, also termed plasma proteins, are proteins present in blood plasma. They serve many... more...

Related Diseases for Blood Protein Disease

Diseases related to Blood Protein Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 294)
# Related Disease Score Top Affiliating Genes
1 sickle cell anemia 31.7 MTHFR IL6 HBG2 HBB F2 BCL11A
2 monoclonal gammopathy of uncertain significance 31.3 SDC1 NSD2 MYOM2 MIR19A MIR126 MAG
3 endocarditis 30.4 SERPINC1 IL6 F2
4 purpura 30.4 SERPINC1 IL6 F2
5 plasmacytoma 30.4 IL6 CD38 B2M
6 peripheral nervous system disease 29.9 MYOM2 MIR126 MAG IL6 ICOSLG H2AC18
7 poems syndrome 10.9
8 giant hemangioma 10.5 SERPINC1 F2
9 dic in newborn 10.5 SERPINC1 F2
10 amyloid tumor 10.5 MYOM2 B2M
11 hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome 10.5 HBG2 HBB
12 waterhouse-friderichsen syndrome 10.5 SERPINC1 F2
13 papilledema 10.5 SERPINC1 MYOM2 F2
14 monoclonal paraproteinemia 10.5 SDC1 IGHV4-38-2
15 cavernous sinus thrombosis 10.5 SERPINC1 F2
16 vitamin k deficiency bleeding 10.5 SERPINC1 PROS1 F2
17 streptococcal toxic-shock syndrome 10.5 MYOM2 IL6
18 purpura fulminans 10.5 SERPINC1 PROS1 F2
19 arteritic anterior ischemic optic neuropathy 10.5 MTHFR F2
20 gamma heavy chain disease 10.5 SDC1 IGHV4-38-2 CD38
21 thoracic outlet syndrome 10.5 SERPINC1 F2
22 pulmonary embolism and infarction 10.5 F2 B2M
23 hepatic infarction 10.5 SERPINC1 F2
24 glomeruloid hemangioma 10.5 SDC1 MYOM2 IL6
25 chronic polyneuropathy 10.5 MYOM2 MAG
26 spinal cord infarction 10.5 SERPINC1 MTHFR F2
27 lateral sinus thrombosis 10.5 SERPINC1 MTHFR F2
28 mental retardation, autosomal dominant 10 10.5 SDC1 IGHV4-38-2 CD38
29 indolent plasma cell myeloma 10.5 MYOM2 IL6
30 livedoid vasculitis 10.5 SERPINC1 MTHFR F2
31 intracranial sinus thrombosis 10.5 SERPINC1 MTHFR F2
32 asymmetric motor neuropathy 10.5 MAG B2M
33 pleural empyema 10.5 SDC1 IL6 F2
34 branch retinal artery occlusion 10.5 SERPINC1 MTHFR F2
35 prothrombin thrombophilia 10.5 MTHFR F2
36 mastoiditis 10.5 SERPINC1 MTHFR F2
37 compartment syndrome 10.5 SERPINC1 IL6 F2
38 post-thrombotic syndrome 10.5 SERPINC1 IL6 F2
39 nonbacterial thrombotic endocarditis 10.5 SERPINC1 IL6 F2
40 infected hydrocele 10.5 SDC1 B2M
41 central retinal artery occlusion 10.5 SERPINC1 MTHFR F2
42 chromosome 13q14 deletion syndrome 10.5 SDC1 IGHV4-38-2 CD38
43 abducens nerve disease 10.5 SERPINC1 F2
44 cerebral sinovenous thrombosis 10.5 PROS1 MTHFR F2
45 osteosclerotic myeloma 10.5 MYOM2 MAG IL6
46 cellulitis 10.5 MYOM2 IL6 F2
47 intracranial thrombosis 10.5 SERPINC1 MTHFR F2
48 lemierre's syndrome 10.5 MTHFR F2
49 pyuria 10.5 IL6 F2 B2M
50 antithrombin iii deficiency 10.5 SERPINC1 MTHFR F2

Graphical network of the top 20 diseases related to Blood Protein Disease:



Diseases related to Blood Protein Disease

Symptoms & Phenotypes for Blood Protein Disease

Drugs & Therapeutics for Blood Protein Disease

Drugs for Blood Protein Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hemostatics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 3b, Randomized Trial of Continuous Revlimid® (Lenalidomide) Therapy Versus Observation Following Induction Therapy That Does Not Include Revlimid, Pomalyst® or Thalomid® in Newly Diagnosed Multiple Myeloma Withdrawn NCT02155634 Phase 3 Lenalidomide
2 A Phase I/II Study of Human Placental Hematopoietic Stem Cell Derived Natural Killer Cells (CYNK 001) in Multiple Myeloma Patients Following Autologous Stem Cell Transplant in the Front-line Setting. Recruiting NCT04309084 Phase 1, Phase 2
3 Bedside Assessment of Coagulation in Post-partum Hemorrhage by Thromboelastography (TEG ®6S) Unknown status NCT03592303
4 Project 2 (Mayo): Transfusion-Induced Alterations of Pulmonary and Immune Function in Mechanically Ventilated Patients Completed NCT00751322

Search NIH Clinical Center for Blood Protein Disease

Cochrane evidence based reviews: blood protein disorders

Genetic Tests for Blood Protein Disease

Anatomical Context for Blood Protein Disease

MalaCards organs/tissues related to Blood Protein Disease:

40
Liver, Bone Marrow

Publications for Blood Protein Disease

Articles related to Blood Protein Disease:

(show top 50) (show all 82)
# Title Authors PMID Year
1
[Blood protein disorders in the course of acute and chronic osteomyelitis in children and the role of protein therapy in their compensation]. 61
606015 1977
2
[Blood protein disorders in collagen diseases. Experiences on 4 cases studied by simple electrophoresis, immunoelectrophoresis and electrophoretic immunoquantification]. 61
5003416 1971
3
[Congenital and acquired blood protein disorders]. 61
5156863 1971
4
[Therapy of blood protein disorders]. 61
4990207 1970
5
[Bovine gamma globulin in rectal administration in the therapy of blood protein disorders]. 61
4192807 1970
6
[Relation between occupation and frequency of blood protein disorders]. 61
5447228 1970
7
[Diagnostic method for blood protein disorders]. 61
4185052 1969
8
[Current studies on electron microscopic leukocyte morphology. Microstructure of the cells in blood protein disorders]. 61
4897034 1969
9
[Blood protein disorders]. 61
4178409 1968
10
[Blood protein disorders in chronic liver diseases: "direct" and "indirect" liver function tests]. 61
5709937 1968
11
[Column gel-filtration. Possibilities of use in the diagnosis of blood protein disorders]. 61
5747755 1968
12
[Determination of digitalemia and its relation to the cardiokinetic effect in patients with blood protein disorders]. 61
5717509 1968
13
[A new test for blood protein disorders]. 61
4185151 1967
14
[The Jones and Thompson test in the diagnosis of blood protein disorders. (Study of the reaction in relation to the serum immunoglobulin level)]. 61
4176301 1967
15
[Dysprotidemic blood protein disorders with paraproteinemia and skeletal diseases]. 61
5963958 1966
16
[Influence of blood protein disorders on the mechanism of experimental hepatic regeneration]. 61
5908186 1966
17
[Blood protein disorders in various internal diseases]. 61
5899212 1965
18
[Immunochemical study on blood protein disorders]. 61
5895144 1965
19
[Anti-liver antibodies in the blood of children affected by liver diseases and by various blood protein disorders]. 61
5849548 1965
20
[Limitations of immunoelectrophoresis in the diagnosis of blood protein disorders]. 61
4961497 1965
21
[LYMPHADENOPATHIES AND BLOOD PROTEIN DISORDERS OR MEDICINAL ORIGIN, SIMULATING A MALIGNANT DISEASE]. 61
14304669 1964
22
[TECHNICAL AND METHODOLOGICAL LIMITATIONS IN THE EVALUATION OF BLOOD PROTEIN DISORDERS]. 61
14269262 1964
23
[THE BLOOD PROTEIN DISORDERS: CLINICAL ASPECTS]. 61
14111276 1964
24
[BLOOD PROTEIN DISORDERS IN SOME KIDNEY DISEASES IN CHILDREN]. 61
14157294 1964
25
[THE PHYSIOPATHOLOGY OF BLOOD PROTEIN DISORDERS]. 61
14111275 1964
26
[CONTRIBUTION OF THE LABORATORY IN THE DIAGNOSIS OF BLOOD PROTEIN DISORDERS]. 61
14111278 1964
27
[THE LUNG IN BLOOD DISEASES, RETICULOSIS AND BLOOD PROTEIN DISORDERS]. 61
14092744 1963
28
[PATHOPHYSIOLOGY OF BLOOD PROTEIN DISORDERS AND GENESIS OF PROTEINS IN DIABETIC ANGIOPATHY. 5. THE PLACE OF THE INTERRENAL SYSTEM AND FUNCTION OF ANABOLIC STEROIDS IN THE DIABETIC-ANGIOPATHIC SERUM PROTEIN METABOLISM]. 61
14093648 1963
29
[Congenital heart diseases and blood protein disorders (study of 40 cases)]. 61
13983228 1962
30
[Study of blood protein disorders in the colitis-hypochlorhydria syndrome]. 61
14495292 1962
31
[Flocculation tests in liver diseases and blood protein disorders]. 61
13770540 1961
32
[Purpura caused by blood protein disorders. Benign hyperglobulinemic purpura with]. 61
13831200 1961
33
[Blood protein disorders in a rabbit infested with Fasciola hepatica. Electrophoretic study]. 61
13749559 1960
34
[Research on the ironbinding function of the blood in patients with blood protein disorders]. 61
13689953 1960
35
[Therapeutic trends in apparently primary blood protein disorders]. 61
13689770 1960
36
[Turbidimetric determination of gamma globulins in the course of blood protein disorders]. 61
13689237 1960
37
[Considerations on the interpretation of tests of blood protein disorders and the electrophoretic spectrum in liver diseases]. 61
14410967 1960
38
[Apropos of some cases of blood protein disorders]. 61
13687175 1960
39
[Study of blood protein disorders]. 61
14421178 1960
40
[The ocular signs of blood protein disorders]. 61
14430971 1959
41
[Relations between erythrocyte clumping & blood protein disorders; clinical & experimental study]. 61
13670734 1959
42
[Significance of blood protein disorders in evaluation of indications for radical surgical intervention in osteoarticular tuberculosis]. 61
13647868 1959
43
[Blood protein disorders induced by injection of various corticosteroids in rat]. 61
13606967 1958
44
[Blood protein disorders in children with burns as a prognostic index]. 61
13624259 1958
45
[Blood protein disorders plasmacytoma; differences in the results of different methods of protein analysis]. 61
13554903 1958
46
[Blood protein disorders]. 61
13574533 1958
47
[The effect of acute hypoxemia on the course of experimental inflammation and blood protein disorders]. 61
13612247 1958
48
[Study of blood protein disorders in cancer patients]. 61
13519562 1957
49
[Use of the Cohn method of fractionation in clinical medicine for analysis of the protein fractions of the sera of normal subjects and those with blood protein disorders]. 61
13499024 1957
50
[Behavior of plasma protein-bound iodine following thyroxin administration in patients with blood protein disorders]. 61
13461955 1957

Variations for Blood Protein Disease

Expression for Blood Protein Disease

Search GEO for disease gene expression data for Blood Protein Disease.

Pathways for Blood Protein Disease

GO Terms for Blood Protein Disease

Cellular components related to Blood Protein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.97 SERPINC1 PROS1 MIR19A MIR126 IL6 HBB
2 extracellular exosome GO:0070062 9.96 SERPINC1 SDC1 PROS1 MIR19A ICOSLG HBB
3 external side of plasma membrane GO:0009897 9.72 SDC1 IGHV4-38-2 ICOSLG F2 B2M
4 hemoglobin complex GO:0005833 9.33 HBG2 HBE1 HBB
5 haptoglobin-hemoglobin complex GO:0031838 9.13 HBG2 HBE1 HBB
6 blood microparticle GO:0072562 9.1 SERPINC1 PROS1 HBG2 HBE1 HBB F2

Biological processes related to Blood Protein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.71 SERPINC1 IL6 F2 B2M
2 leukocyte migration GO:0050900 9.67 SDC1 PROS1 MAG F2
3 cellular oxidant detoxification GO:0098869 9.61 HBG2 HBE1 HBB
4 hemostasis GO:0007599 9.5 SERPINC1 PROS1 F2
5 regulation of blood coagulation GO:0030193 9.46 SERPINC1 F2
6 negative regulation of neuron projection development GO:0010977 9.46 MAG CD38 BCL11A B2M
7 hydrogen peroxide catabolic process GO:0042744 9.43 HBG2 HBE1 HBB
8 oxygen transport GO:0015671 9.13 HBG2 HBE1 HBB
9 blood coagulation GO:0007596 9.1 SERPINC1 PROS1 HBG2 HBE1 HBB F2

Molecular functions related to Blood Protein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 9.54 HBG2 HBE1 HBB
2 oxygen binding GO:0019825 9.5 HBG2 HBE1 HBB
3 oxygen carrier activity GO:0005344 9.43 HBG2 HBE1 HBB
4 organic acid binding GO:0043177 9.33 HBG2 HBE1 HBB
5 haptoglobin binding GO:0031720 9.13 HBG2 HBE1 HBB
6 hemoglobin alpha binding GO:0031721 8.8 HBG2 HBE1 HBB

Sources for Blood Protein Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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