MCID: BLT003
MIFTS: 36

Blue Toe Syndrome

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Blue Toe Syndrome

MalaCards integrated aliases for Blue Toe Syndrome:

Name: Blue Toe Syndrome 12 44 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:14121
MeSH 44 D018438
UMLS 72 C0242645

Summaries for Blue Toe Syndrome

MalaCards based summary : Blue Toe Syndrome is related to buerger disease and antiphospholipid syndrome. An important gene associated with Blue Toe Syndrome is ARG1 (Arginase 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Acetylcholine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and kidney, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 75 Blue toe syndrome is a situation that may reflect atherothrombotic microembolism, causing transient... more...

Related Diseases for Blue Toe Syndrome

Diseases related to Blue Toe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
# Related Disease Score Top Affiliating Genes
1 buerger disease 30.3 SERPINE1 F2
2 antiphospholipid syndrome 30.1 SERPINC1 F3 F2
3 essential thrombocythemia 30.1 SERPINE1 F3 F2
4 thrombophilia 29.6 SERPINE1 SERPINC1 F3 F2
5 thrombocytosis 29.4 SERPINC1 F3 F2 CRP
6 disseminated intravascular coagulation 29.3 SERPINE1 SERPINC1 F3 F2
7 thrombophilia due to thrombin defect 29.3 SERPINE1 SERPINC1 F3 F2
8 coronary artery anomaly 29.1 SERPINE1 PLG F2 CRP
9 peripheral vascular disease 28.8 SERPINE1 SERPINC1 F3 F2 CRP
10 vascular disease 27.9 SERPINE1 SERPINC1 PLG F3 F2 CRP
11 cholesterol embolism 11.7
12 spinal cord infarction 10.5 SERPINC1 F2
13 prothrombin deficiency, congenital 10.5 SERPINC1 F2
14 sneddon syndrome 10.5 SERPINC1 F2
15 malignant otitis externa 10.5 F2 CRP
16 esophageal varix 10.5 SERPINC1 F2
17 japanese spotted fever 10.4 SERPINC1 CRP
18 chronic thromboembolic pulmonary hypertension 10.4 F2 CRP
19 fibrinolytic defect 10.4 SERPINE1 SERPINC1
20 lipid pneumonia 10.4 CRP ARG1
21 abdominal tuberculosis 10.4 F2 CRP
22 hypersplenism 10.4 SERPINC1 F2
23 antithrombin iii deficiency 10.4 SERPINC1 F2
24 ischemic neuropathy 10.4 F2 CRP
25 central retinal vein occlusion 10.4 SERPINC1 F2
26 sticky platelet syndrome 10.4 SERPINE1 SERPINC1
27 argentine hemorrhagic fever 10.4 SERPINE1 SERPINC1
28 aspirin allergy 10.4 SERPINE1 SERPINC1
29 dysfibrinogenemia 10.4 SERPINC1 F2
30 cryptogenic cirrhosis 10.4 SERPINE1 F2
31 meningococcemia 10.4 SERPINE1 SERPINC1
32 heparin-induced thrombocytopenia 10.4 SERPINC1 F3
33 hemophilia 10.4 F3 F2
34 placental abruption 10.4 SERPINC1 F2
35 afibrinogenemia 10.4 F3 F2
36 protein c deficiency 10.3 SERPINC1 F2
37 prothrombin deficiency 10.3 F3 F2
38 angina pectoris 10.3 SERPINC1 CRP
39 cerebral sinovenous thrombosis 10.3 F3 F2
40 posterior myocardial infarction 10.3 SERPINC1 PCLAF
41 legg-calve-perthes disease 10.3 SERPINE1 SERPINC1
42 arteritic anterior ischemic optic neuropathy 10.3 F2 CRP
43 qualitative platelet defect 10.3 F3 F2
44 nonarteritic anterior ischemic optic neuropathy 10.3 SERPINC1 F2
45 hantavirus pulmonary syndrome 10.3 F3 F2
46 alcohol-related birth defect 10.3 F3 F2
47 von willebrand disease, type 1 10.3 F3 F2
48 splenic disease 10.3 F3 F2
49 factor xii deficiency 10.3 SERPINC1 F3
50 pulmonary immaturity 10.3 SERPINC1 F3

Graphical network of the top 20 diseases related to Blue Toe Syndrome:



Diseases related to Blue Toe Syndrome

Symptoms & Phenotypes for Blue Toe Syndrome

MGI Mouse Phenotypes related to Blue Toe Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 CRP F2 F3 PLG SERPINC1 SERPINE1
2 hematopoietic system MP:0005397 9.7 ARG1 F2 F3 PCLAF PLG SERPINC1
3 homeostasis/metabolism MP:0005376 9.56 ARG1 CRP F2 F3 PLG RBMS1
4 immune system MP:0005387 9.23 ARG1 CRP F2 F3 PCLAF PLG

Drugs & Therapeutics for Blue Toe Syndrome

Drugs for Blue Toe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2 Neurotransmitter Agents Phase 4
3 Neuromuscular Agents Phase 4
4 Cholinergic Agents Phase 4
5 abobotulinumtoxinA Phase 4
6 Peripheral Nervous System Agents Phase 4
7 Acetylcholine Release Inhibitors Phase 4
8 Vasopressins Phase 4
9 Botulinum Toxins Phase 4
10 Arginine Vasopressin Phase 4
11 Botulinum Toxins, Type A Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Botulinum Toxin for Treatment of Catocholamine Induced Finger Necrosis - a Double Blind Randomized Control Prospective Study. Unknown status NCT01500668 Phase 4 Botox;Placebo

Search NIH Clinical Center for Blue Toe Syndrome

Cochrane evidence based reviews: blue toe syndrome

Genetic Tests for Blue Toe Syndrome

Anatomical Context for Blue Toe Syndrome

MalaCards organs/tissues related to Blue Toe Syndrome:

41
Skin, Bone, Kidney, Bone Marrow

Publications for Blue Toe Syndrome

Articles related to Blue Toe Syndrome:

(show top 50) (show all 135)
# Title Authors PMID Year
1
Toe necrosis: report of uncommon aetiology. 38
31302625 2019
2
Blue toe syndrome in cutaneous polyarteritis nodosa. 38
29534226 2018
3
[A POEMS syndrome revealed by a blue toe syndrome]. 38
29288001 2018
4
Blue toe syndrome as a first sign of systemic sclerosis. 38
29305361 2018
5
[Blue toe syndrome as a clinical finding of pheochromocytoma]. 38
30285931 2018
6
The usefulness of Duplex Doppler ultrasound in the angiological and dermatological diagnosis of patients with blue toe syndrome. 38
29507564 2017
7
Blue Toe Syndrome as an Early Sign of Disseminated Intravascular Coagulation. 38
27274647 2016
8
The Place of Nailfold Capillaroscopy Among Instrumental Methods for Assessment of Some Peripheral Ischaemic Syndromes in Rheumatology. 38
27552783 2016
9
Cholesterol embolization syndrome: A report of two cases. 38
27138317 2016
10
Comparison of posterior and medial approaches for popliteal artery aneurysms. 38
26372190 2015
11
The Pathogenesis and Diagnosis of Thromboangiitis obliterans: Is It Still a Mystery? 38
26771983 2015
12
Blue toe syndrome, ischemic pain treated with digital block. 38
25605677 2015
13
A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome. 38
25534490 2015
14
A case of antiphospholipid syndrome refractory to secondary anticoagulating prophylaxis after deep vein thrombosis-pulmonary embolism. 38
25580146 2014
15
[Skin and chronic kidney disease]. 38
25315722 2014
16
Blue toe syndrome--reply. 38
24810698 2014
17
Blue toe syndrome: a complication of intra-arterial technique, not intra-arterial chemotherapy for retinoblastoma. 38
24810697 2014
18
Outcomes of abdominal aortic aneurysm with aortic neck thrombus after endovascular abdominal aortic aneurysm repair. 38
25065091 2014
19
["Blue-toe" syndrome as a possible complication of the abdominal aortic aneurysm: a report of two cases]. 38
24839781 2014
20
Skin lesions simulating blue toe syndrome caused by prolonged contact with a millipede. 38
24861307 2014
21
Blue toe syndrome treated with sympathectomy in a patient with acute renal failure caused by cholesterol embolization. 38
26877940 2013
22
[Foot lesions]. 38
24114468 2013
23
Toe Necrosis, Etiologies and Management, a Case Series. 38
26199887 2013
24
Coil embolization of persistent sciatic artery pseudoaneurysm presenting as blue toe syndrome, a rare case. 38
24426603 2013
25
Blue toe syndrome as a complication of intra-arterial chemotherapy for retinoblastoma. 38
23764710 2013
26
The cholesterol emboli syndrome in atherosclerosis. 38
23423524 2013
27
Compression of the dorsalis pedis artery: a novel cause of blue toe syndrome. 38
22983548 2012
28
[Atheromatous aorta: clinical pitfall in cardiovascular surgery]. 38
22868419 2012
29
Aortic atherosclerosis and embolic events. 38
22437371 2012
30
Cholesterol embolization syndrome. 38
21993354 2011
31
Blue toe syndrome and sunitinib. 38
21136131 2011
32
Complete removal of infected abdominal aortic stent-graft with suprarenal fixation. 38
21621972 2011
33
Epithelioid hemangioendothelioma as a rare cause of blue toe syndrome. 38
21571496 2011
34
[Blue toe syndrome as the presenting sign of a popliteal artery aneurysm]. 38
21621180 2011
35
[Blue toe syndrome--a rare but possible complication of anticoagulant therapy]. 38
21755807 2011
36
Blue toe syndrome as a clue to the underlying cause of acute renal failure. 38
25949485 2010
37
Isolated blue toe syndrome as the initial sign of Wegener granulomatosis. 38
20609674 2010
38
Cutaneous reactive angiomatosis associated with cholesterol embolism. 38
19614996 2010
39
[Purple extremities in black-skinned patients: blue toe syndrome as presenting sign of antiphospholipid antibody syndrome]. 38
20734601 2010
40
Treatment of symptomatic mobile aortic thrombus. 38
20690525 2010
41
Locked-in Syndrome and Blue Toe Syndrome Caused by Cardiopulmonary Bypass. 38
23074585 2010
42
[The blue toe syndrome and its pathogenic significance. A case report]. 38
20526478 2009
43
[Cholesterol crystal embolism and renal insufficiency: case report and literature review]. 38
20030288 2009
44
Cholesterol crystal embolization: a possible complication of peripheral endovascular interventions. 38
18840042 2008
45
Superficial femoral artery thrombosis as a cause for distal embolism in primary antiphospholipid syndrome. 38
18644492 2008
46
Blue toe syndrome. 38
17906493 2007
47
Native superficial femoral artery peripheral atherectomy site pseudoaneurysm: a case report. 38
17826246 2007
48
[Case report of cholesterol crystal embolism 1 month after carotid stenting]. 38
17695780 2007
49
[Pernio as cause of a blue toe syndrome]. 38
16878289 2007
50
[Blue toe syndrome; a sign of end-arterial occlusion]. 38
17624153 2007

Variations for Blue Toe Syndrome

Expression for Blue Toe Syndrome

Search GEO for disease gene expression data for Blue Toe Syndrome.

Pathways for Blue Toe Syndrome

GO Terms for Blue Toe Syndrome

Cellular components related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 SERPINE1 SERPINC1 PLG F3 F2 CRP
2 collagen-containing extracellular matrix GO:0062023 9.46 SERPINE1 SERPINC1 PLG F3
3 blood microparticle GO:0072562 9.43 SERPINC1 PLG F2
4 extracellular space GO:0005615 9.17 SERPINE1 SERPINC1 PLG F3 F2 CRP

Biological processes related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.58 SERPINC1 PLG F2
2 blood coagulation GO:0007596 9.56 SERPINC1 PLG F3 F2
3 acute-phase response GO:0006953 9.43 F2 CRP
4 regulation of blood coagulation GO:0030193 9.37 SERPINC1 F2
5 fibrinolysis GO:0042730 9.33 SERPINE1 PLG F2
6 positive regulation of blood coagulation GO:0030194 9.32 SERPINE1 F2
7 negative regulation of fibrinolysis GO:0051918 9.13 SERPINE1 PLG F2
8 hemostasis GO:0007599 8.92 SERPINC1 PLG F3 F2

Molecular functions related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.81 SERPINE1 SERPINC1 RBMS1 PLG PCLAF F3
2 serine-type endopeptidase activity GO:0004252 9.13 PLG F3 F2
3 protease binding GO:0002020 8.8 SERPINE1 SERPINC1 F3

Sources for Blue Toe Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....