MCID: BLT003
MIFTS: 35

Blue Toe Syndrome

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Blue Toe Syndrome

MalaCards integrated aliases for Blue Toe Syndrome:

Name: Blue Toe Syndrome 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14121
MeSH 44 D018438
UMLS 73 C0242645

Summaries for Blue Toe Syndrome

MalaCards based summary : Blue Toe Syndrome is related to disseminated intravascular coagulation and cholesterol embolism. An important gene associated with Blue Toe Syndrome is ARG1 (Arginase 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Acetylcholine and onabotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and bone marrow, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Blue toe syndrome is a situation that may reflect atherothrombotic microembolism, causing transient... more...

Related Diseases for Blue Toe Syndrome

Diseases related to Blue Toe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 disseminated intravascular coagulation 29.7 F2 F3 SERPINC1 SERPINE1
2 cholesterol embolism 11.2
3 spinal cord infarction 10.2 F2 SERPINC1
4 prothrombin deficiency, congenital 10.2 F2 SERPINC1
5 sneddon syndrome 10.2 F2 SERPINC1
6 esophageal varix 10.2 F2 SERPINC1
7 malignant otitis externa 10.2 CRP F2
8 burns 10.2 CRP SERPINC1
9 japanese spotted fever 10.2 CRP SERPINC1
10 fibrinolytic defect 10.2 SERPINC1 SERPINE1
11 chronic thromboembolic pulmonary hypertension 10.2 CRP F2
12 antithrombin iii deficiency 10.2 F2 SERPINC1
13 abdominal tuberculosis 10.2 CRP F2
14 hypersplenism 10.2 F2 SERPINC1
15 ischemic neuropathy 10.2 CRP F2
16 aspirin allergy 10.2 SERPINC1 SERPINE1
17 argentine hemorrhagic fever 10.2 SERPINC1 SERPINE1
18 lipid pneumonia 10.2 ARG1 CRP
19 sticky platelet syndrome 10.2 SERPINC1 SERPINE1
20 central retinal vein occlusion 10.2 F2 SERPINC1
21 cryptogenic cirrhosis 10.2 F2 SERPINE1
22 hemophilia 10.2 F2 F3
23 dysfibrinogenemia 10.2 F2 SERPINC1
24 heparin-induced thrombocytopenia 10.2 F3 SERPINC1
25 afibrinogenemia 10.2 F2 F3
26 pyelitis 10.2 CRP LYZ
27 meningococcemia 10.1 SERPINC1 SERPINE1
28 ischemic optic neuropathy 10.1 F2 SERPINC1
29 prothrombin deficiency 10.1 F2 F3
30 cerebral sinovenous thrombosis 10.1 F2 F3
31 posterior myocardial infarction 10.1 PCLAF SERPINC1
32 qualitative platelet defect 10.1 F2 F3
33 xanthogranulomatous pyelonephritis 10.1 CRP LYZ
34 renal tuberculosis 10.1 CRP LYZ
35 alcohol-related birth defect 10.1 F2 F3
36 hantavirus pulmonary syndrome 10.1 F2 F3
37 von willebrand disease, type 1 10.1 F2 F3
38 legg-calve-perthes disease 10.1 SERPINC1 SERPINE1
39 vascular hemostatic disease 10.1 F2 F3
40 placental abruption 10.1 F2 SERPINC1
41 buerger disease 10.1 F2 SERPINE1
42 splenic disease 10.1 F2 F3
43 arteritic anterior ischemic optic neuropathy 10.1 CRP F2
44 pulmonary hemosiderosis 10.1 CRP LYZ
45 angina pectoris 10.1 CRP SERPINC1
46 factor xii deficiency 10.1 F3 SERPINC1
47 multicentric castleman disease 10.1 CRP F3
48 protein c deficiency 10.1 F2 SERPINC1
49 pulmonary immaturity 10.1 F3 SERPINC1
50 catastrophic antiphospholipid syndrome 10.1 F3 SERPINE1

Graphical network of the top 20 diseases related to Blue Toe Syndrome:



Diseases related to Blue Toe Syndrome

Symptoms & Phenotypes for Blue Toe Syndrome

MGI Mouse Phenotypes related to Blue Toe Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 ARG1 F2 F3 LYZ PCLAF PLG
2 homeostasis/metabolism MP:0005376 9.97 ARG1 CRP F2 F3 LYZ PLG
3 cardiovascular system MP:0005385 9.95 CRP F2 F3 LYZ PLG SERPINC1
4 immune system MP:0005387 9.91 ARG1 CRP F2 F3 LYZ PCLAF
5 mortality/aging MP:0010768 9.56 ARG1 F2 F3 LYZ PLG RBMS1
6 liver/biliary system MP:0005370 9.55 ARG1 LYZ PLG SERPINC1 SERPINE1
7 respiratory system MP:0005388 9.02 F2 F3 LYZ PLG SERPINE1

Drugs & Therapeutics for Blue Toe Syndrome

Drugs for Blue Toe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 onabotulinumtoxinA Phase 4
3 Peripheral Nervous System Agents Phase 4
4 Cholinergic Agents Phase 4
5 Neurotransmitter Agents Phase 4
6 Botulinum Toxins Phase 4
7 Botulinum Toxins, Type A Phase 4
8 abobotulinumtoxinA Phase 4
9 Acetylcholine Release Inhibitors Phase 4
10 Arginine Vasopressin Phase 4
11 Neuromuscular Agents Phase 4
12 Vasopressins Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Botulinum Toxin A for Treatment of Catocholamine Induced Finger Necrosis Unknown status NCT01500668 Phase 4 Botox;Placebo

Search NIH Clinical Center for Blue Toe Syndrome

Cochrane evidence based reviews: blue toe syndrome

Genetic Tests for Blue Toe Syndrome

Anatomical Context for Blue Toe Syndrome

MalaCards organs/tissues related to Blue Toe Syndrome:

41
Bone, Skin, Bone Marrow, Liver, Heart, Spinal Cord, Placenta

Publications for Blue Toe Syndrome

Articles related to Blue Toe Syndrome:

(show top 50) (show all 58)
# Title Authors Year
1
Blue toe syndrome in cutaneous polyarteritis nodosa. ( 29534226 )
2018
2
Blue toe syndrome as a first sign of systemic sclerosis. ( 29305361 )
2018
3
The usefulness of Duplex Doppler ultrasound in the angiological and dermatological diagnosis of patients with blue toe syndrome. ( 29507564 )
2017
4
Blue Toe Syndrome as an Early Sign of Disseminated Intravascular Coagulation. ( 27274647 )
2016
5
Blue toe syndrome, ischemic pain treated with digital block. ( 25605677 )
2015
6
Skin lesions simulating blue toe syndrome caused by prolonged contact with a millipede. ( 24861307 )
2014
7
Blue toe syndrome--reply. ( 24810698 )
2014
8
A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome. ( 25534490 )
2014
9
Blue toe syndrome: a complication of intra-arterial technique, not intra-arterial chemotherapy for retinoblastoma. ( 24810697 )
2014
10
Blue toe syndrome treated with sympathectomy in a patient with acute renal failure caused by cholesterol embolization. ( 26877940 )
2013
11
Blue toe syndrome as a complication of intra-arterial chemotherapy for retinoblastoma. ( 23764710 )
2013
12
Coil embolization of persistent sciatic artery pseudoaneurysm presenting as blue toe syndrome, a rare case. ( 24426603 )
2013
13
Compression of the dorsalis pedis artery: a novel cause of blue toe syndrome. ( 22983548 )
2012
14
Blue toe syndrome and sunitinib. ( 21136131 )
2011
15
Epithelioid hemangioendothelioma as a rare cause of blue toe syndrome. ( 21571496 )
2011
16
Isolated blue toe syndrome as the initial sign of Wegener granulomatosis. ( 20609674 )
2010
17
Locked-in Syndrome and Blue Toe Syndrome Caused by Cardiopulmonary Bypass. ( 23074585 )
2010
18
Blue toe syndrome as a clue to the underlying cause of acute renal failure. ( 25949485 )
2010
19
Blue toe syndrome. ( 17906493 )
2007
20
Spontaneous dissection of the popliteal artery in a young man. A rare cause of the blue toe syndrome. ( 16520732 )
2006
21
Renal failure associated with blue toe syndrome: effective treatment with intravenous prostaglandin E-1. ( 16874430 )
2006
22
Case report: Blue toe syndrome caused by a true crural aneurysm. ( 12813416 )
2003
23
Blue toe syndrome: a rare complication of acute pancreatitis. ( 12555011 )
2003
24
Atheroembolic signals detected by Doppler ultrasound scan monitoring in a patient with blue toe syndrome: report of a case. ( 12376800 )
2002
25
Angioplasty with stenting is effective in treating blue toe syndrome. ( 11951102 )
2002
26
A vitamin K antagonist rapidly reverses a blue toe syndrome in a patient with lupus anticoagulant and antiprothrombin antibodies. ( 12152242 )
2002
27
The blue toe syndrome during oral anticoagulant therapy with acenocoumarol. ( 11341514 )
2001
28
Blue toe syndrome: treatment with intra-arterial stents and review of therapies. ( 10834489 )
2000
29
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. ( 11399611 )
2000
30
Special exhibit for the SCVIR Annual Meeting Film Panel Session: diagnosis and discussion of cases 5-8. Society of Cardiovascular & Interventional Radiology. Case 6. Blue-toe syndrome secondary to embolization from a complex right common iliac artery plaque containing fresh thrombus material. ( 10498409 )
1999
31
Blue toe syndrome after initiation of low-dose oral anticoagulation. ( 9620888 )
1998
32
Blue toe syndrome associated with rapidly progressive glomerulonephritis: ultimately revealed essential mixed cryoglobulinemia. ( 9044465 )
1997
33
Transesophageal echocardiographic findings in blue toe syndrome exacerbated by anticoagulation. ( 8943451 )
1996
34
Evaluation and management of cholesterol embolization and the blue toe syndrome. ( 8889381 )
1996
35
Additional causes of the blue toe syndrome. ( 7791402 )
1995
36
Blue toe syndrome from a "coral reef" aorta. ( 8746834 )
1995
37
Femoral artery hypoplasia and persistent sciatic artery with blue toe syndrome: a case report, histologic analysis and review of the literature. ( 7963875 )
1994
38
External iliac ligation and axillary-bifemoral bypass for blue toe syndrome. ( 8284757 )
1994
39
Reversal of gangrenous lesions in the blue toe syndrome with lovastatin--a case report. ( 8214780 )
1993
40
Blue toe syndrome. Causes and management. ( 1444678 )
1992
41
Atherectomy of the distal aorta using a "kissing-balloon" technique for the treatment of blue toe syndrome. ( 1535174 )
1992
42
Blue toe syndrome. ( 1747352 )
1991
43
Corticosteroid-associated blue toe syndrome: role of antiphospholipid antibodies. ( 2240906 )
1990
44
Atherothrombotic microembolism of the lower extremities (the blue toe syndrome) from atherosclerotic non-aneurysmal aortic plaques. ( 2324190 )
1990
45
Blue toe syndrome: treatment with percutaneous atherectomy. ( 2813788 )
1989
46
Blue toe syndrome: treatment with anticoagulants and delayed percutaneous transluminal angioplasty. ( 2962224 )
1988
47
Digital arterial embolism-true blue toe syndrome. A histopathologic analysis. ( 3246660 )
1988
48
The blue toe syndrome: hemodynamics and therapeutic correlates of outcome. ( 3512857 )
1986
49
Primary thrombocythemia: another cause of the "blue toe syndrome". ( 3711871 )
1986
50
Blue toe syndrome. ( 3716963 )
1986

Variations for Blue Toe Syndrome

Expression for Blue Toe Syndrome

Search GEO for disease gene expression data for Blue Toe Syndrome.

Pathways for Blue Toe Syndrome

GO Terms for Blue Toe Syndrome

Cellular components related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ARG1 CRP F2 F3 LYZ PLG
2 collagen-containing extracellular matrix GO:0062023 9.46 F3 PLG SERPINC1 SERPINE1
3 blood microparticle GO:0072562 9.43 F2 PLG SERPINC1
4 extracellular space GO:0005615 9.23 ARG1 CRP F2 F3 LYZ PLG

Biological processes related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.62 F2 LYZ PLG SERPINC1
2 blood coagulation GO:0007596 9.56 F2 F3 PLG SERPINC1
3 acute-phase response GO:0006953 9.43 CRP F2
4 positive regulation of blood coagulation GO:0030194 9.4 F2 SERPINE1
5 regulation of blood coagulation GO:0030193 9.37 F2 SERPINC1
6 fibrinolysis GO:0042730 9.33 F2 PLG SERPINE1
7 negative regulation of fibrinolysis GO:0051918 9.13 F2 PLG SERPINE1
8 hemostasis GO:0007599 8.92 F2 F3 PLG SERPINC1

Molecular functions related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 F2 F3 PLG
2 protease binding GO:0002020 8.8 F3 SERPINC1 SERPINE1

Sources for Blue Toe Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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