MCID: BLT003
MIFTS: 31

Blue Toe Syndrome

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Blue Toe Syndrome

MalaCards integrated aliases for Blue Toe Syndrome:

Name: Blue Toe Syndrome 12 43 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:14121
MeSH 43 D018438
UMLS 71 C0242645

Summaries for Blue Toe Syndrome

MalaCards based summary : Blue Toe Syndrome is related to cholesterol embolism and thrombophilia. An important gene associated with Blue Toe Syndrome is RBMS1 (RNA Binding Motif Single Stranded Interacting Protein 1), and among its related pathways/superpathways are Collagen chain trimerization and Formation of Fibrin Clot (Clotting Cascade). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and bone, and related phenotype is cardiovascular system.

Wikipedia : 74 Blue toe syndrome is a situation that may reflect atherothrombotic microembolism, causing transient... more...

Related Diseases for Blue Toe Syndrome

Diseases related to Blue Toe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 cholesterol embolism 31.9 SERPINC1 F2 CRP
2 thrombophilia 29.3 SERPINC1 F3 F2
3 thrombophilia due to thrombin defect 29.0 SERPINC1 F3 F2
4 essential thrombocythemia 28.8 SERPINC1 F3 F2 CRP
5 antiphospholipid syndrome 28.7 SERPINC1 F3 F2 CRP
6 mitral valve stenosis 28.5 SERPINC1 F3 F2 CRP
7 vascular disease 28.5 SERPINC1 F3 F2 CRP
8 disseminated intravascular coagulation 28.5 SERPINC1 F3 F2 CRP
9 thrombocytosis 28.5 SERPINC1 F3 F2 CRP
10 peripheral vascular disease 28.5 SERPINC1 F3 F2 CRP
11 thrombocytopenia 28.4 SERPINC1 F3 F2 CRP
12 kidney disease 10.2
13 vasculitis 10.2
14 cardiac tuberculosis 10.2 SERPINC1 CRP
15 abducens nerve disease 10.1 SERPINC1 CRP
16 cyanosis, transient neonatal 10.1
17 heparin-induced thrombocytopenia 10.1 SERPINC1 F3
18 vulvar angiokeratoma 10.1 SERPINC1 F3
19 leech infestation 10.1 SERPINC1 F3
20 thrombophlebitis migrans 10.1 SERPINC1 F3
21 aortic aneurysm, familial abdominal, 1 10.0
22 retinoblastoma 10.0
23 acute kidney failure 10.0
24 aortic aneurysm 10.0
25 familial retinoblastoma 10.0
26 aneurysm 10.0
27 paresthesia 10.0
28 carotid artery thrombosis 10.0 SERPINC1 F3
29 factor xii deficiency 10.0 SERPINC1 F3
30 epidural abscess 10.0 F3 CRP
31 aspiration pneumonitis 10.0 F3 CRP
32 coronary thrombosis 10.0 SERPINC1 F3
33 hantavirus hemorrhagic fever with renal syndrome 10.0 F3 CRP
34 hepatic veno-occlusive disease 10.0 SERPINC1 F3
35 necrotizing fasciitis 10.0 F3 CRP
36 retinal artery occlusion 10.0 SERPINC1 F2
37 multicentric castleman disease 10.0 F3 CRP
38 angina pectoris 10.0 F3 CRP
39 mycoplasma pneumoniae pneumonia 10.0 F3 CRP
40 scrub typhus 9.9 F3 CRP
41 thrombotic thrombocytopenic purpura 9.9 SERPINC1 F3
42 pyoderma 9.9 F3 CRP
43 spinal cord infarction 9.9 SERPINC1 F2
44 eclampsia 9.9 SERPINC1 F2
45 sudden sensorineural hearing loss 9.9 SERPINC1 F2
46 lateral sinus thrombosis 9.9 SERPINC1 F2
47 waterhouse-friderichsen syndrome 9.9 SERPINC1 F2
48 livedoid vasculitis 9.9 SERPINC1 F2
49 thoracic outlet syndrome 9.9 SERPINC1 F2
50 prothrombin deficiency, congenital 9.9 SERPINC1 F2

Graphical network of the top 20 diseases related to Blue Toe Syndrome:



Diseases related to Blue Toe Syndrome

Symptoms & Phenotypes for Blue Toe Syndrome

MGI Mouse Phenotypes related to Blue Toe Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.02 CRP F2 F3 RBMS1 SERPINC1

Drugs & Therapeutics for Blue Toe Syndrome

Drugs for Blue Toe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2 abobotulinumtoxinA Phase 4
3 Neurotransmitter Agents Phase 4
4 Acetylcholine Release Inhibitors Phase 4
5 Neuromuscular Agents Phase 4
6 Cholinergic Agents Phase 4
7 Vasopressins Phase 4
8 Botulinum Toxins, Type A Phase 4
9 Botulinum Toxins Phase 4
10 Arginine Vasopressin Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Botulinum Toxin for Treatment of Catocholamine Induced Finger Necrosis - a Double Blind Randomized Control Prospective Study. Unknown status NCT01500668 Phase 4 Botox;Placebo

Search NIH Clinical Center for Blue Toe Syndrome

Cochrane evidence based reviews: blue toe syndrome

Genetic Tests for Blue Toe Syndrome

Anatomical Context for Blue Toe Syndrome

MalaCards organs/tissues related to Blue Toe Syndrome:

40
Skin, Bone Marrow, Bone, Kidney

Publications for Blue Toe Syndrome

Articles related to Blue Toe Syndrome:

(show top 50) (show all 135)
# Title Authors PMID Year
1
Toe necrosis: report of uncommon aetiology. 61
31302625 2019
2
Blue toe syndrome in cutaneous polyarteritis nodosa. 61
29534226 2018
3
[A POEMS syndrome revealed by a blue toe syndrome]. 61
29288001 2018
4
Blue toe syndrome as a first sign of systemic sclerosis. 61
29305361 2018
5
[Blue toe syndrome as a clinical finding of pheochromocytoma]. 61
30285931 2018
6
The usefulness of Duplex Doppler ultrasound in the angiological and dermatological diagnosis of patients with blue toe syndrome. 61
29507564 2017
7
Blue Toe Syndrome as an Early Sign of Disseminated Intravascular Coagulation. 61
27274647 2016
8
The Place of Nailfold Capillaroscopy Among Instrumental Methods for Assessment of Some Peripheral Ischaemic Syndromes in Rheumatology. 61
27552783 2016
9
Cholesterol embolization syndrome: A report of two cases. 61
27138317 2016
10
Comparison of posterior and medial approaches for popliteal artery aneurysms. 61
26372190 2015
11
The Pathogenesis and Diagnosis of Thromboangiitis obliterans: Is It Still a Mystery? 61
26771983 2015
12
Blue toe syndrome, ischemic pain treated with digital block. 61
25605677 2015
13
A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome. 61
25534490 2015
14
A case of antiphospholipid syndrome refractory to secondary anticoagulating prophylaxis after deep vein thrombosis-pulmonary embolism. 61
25580146 2014
15
[Skin and chronic kidney disease]. 61
25315722 2014
16
Blue toe syndrome--reply. 61
24810698 2014
17
Blue toe syndrome: a complication of intra-arterial technique, not intra-arterial chemotherapy for retinoblastoma. 61
24810697 2014
18
Outcomes of abdominal aortic aneurysm with aortic neck thrombus after endovascular abdominal aortic aneurysm repair. 61
25065091 2014
19
["Blue-toe" syndrome as a possible complication of the abdominal aortic aneurysm: a report of two cases]. 61
24839781 2014
20
Skin lesions simulating blue toe syndrome caused by prolonged contact with a millipede. 61
24861307 2014
21
Blue toe syndrome treated with sympathectomy in a patient with acute renal failure caused by cholesterol embolization. 61
26877940 2013
22
[Foot lesions]. 61
24114468 2013
23
Toe Necrosis, Etiologies and Management, a Case Series. 61
26199887 2013
24
Coil embolization of persistent sciatic artery pseudoaneurysm presenting as blue toe syndrome, a rare case. 61
24426603 2013
25
Blue toe syndrome as a complication of intra-arterial chemotherapy for retinoblastoma. 61
23764710 2013
26
The cholesterol emboli syndrome in atherosclerosis. 61
23423524 2013
27
Compression of the dorsalis pedis artery: a novel cause of blue toe syndrome. 61
22983548 2012
28
[Atheromatous aorta: clinical pitfall in cardiovascular surgery]. 61
22868419 2012
29
Aortic atherosclerosis and embolic events. 61
22437371 2012
30
Cholesterol embolization syndrome. 61
21993354 2011
31
Blue toe syndrome and sunitinib. 61
21136131 2011
32
Complete removal of infected abdominal aortic stent-graft with suprarenal fixation. 61
21621972 2011
33
Epithelioid hemangioendothelioma as a rare cause of blue toe syndrome. 61
21571496 2011
34
[Blue toe syndrome as the presenting sign of a popliteal artery aneurysm]. 61
21621180 2011
35
[Blue toe syndrome--a rare but possible complication of anticoagulant therapy]. 61
21755807 2011
36
Blue toe syndrome as a clue to the underlying cause of acute renal failure. 61
25949485 2010
37
Isolated blue toe syndrome as the initial sign of Wegener granulomatosis. 61
20609674 2010
38
Cutaneous reactive angiomatosis associated with cholesterol embolism. 61
19614996 2010
39
[Purple extremities in black-skinned patients: blue toe syndrome as presenting sign of antiphospholipid antibody syndrome]. 61
20734601 2010
40
Treatment of symptomatic mobile aortic thrombus. 61
20690525 2010
41
Locked-in Syndrome and Blue Toe Syndrome Caused by Cardiopulmonary Bypass. 61
23074585 2010
42
[The blue toe syndrome and its pathogenic significance. A case report]. 61
20526478 2009
43
[Cholesterol crystal embolism and renal insufficiency: case report and literature review]. 61
20030288 2009
44
Cholesterol crystal embolization: a possible complication of peripheral endovascular interventions. 61
18840042 2008
45
Superficial femoral artery thrombosis as a cause for distal embolism in primary antiphospholipid syndrome. 61
18644492 2008
46
Blue toe syndrome. 61
17906493 2007
47
Native superficial femoral artery peripheral atherectomy site pseudoaneurysm: a case report. 61
17826246 2007
48
[Case report of cholesterol crystal embolism 1 month after carotid stenting]. 61
17695780 2007
49
[Pernio as cause of a blue toe syndrome]. 61
16878289 2007
50
[Blue toe syndrome; a sign of end-arterial occlusion]. 61
17624153 2007

Variations for Blue Toe Syndrome

Expression for Blue Toe Syndrome

Search GEO for disease gene expression data for Blue Toe Syndrome.

Pathways for Blue Toe Syndrome

Pathways related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.06 SERPINC1 F3 F2
2
Show member pathways
11.33 SERPINC1 F3 F2
3 10.96 SERPINC1 F3 F2

GO Terms for Blue Toe Syndrome

Cellular components related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 8.8 SERPINC1 F3 F2

Biological processes related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.33 SERPINC1 F3 F2
2 acute-phase response GO:0006953 9.26 F2 CRP
3 regulation of blood coagulation GO:0030193 8.96 SERPINC1 F2
4 hemostasis GO:0007599 8.8 SERPINC1 F3 F2

Sources for Blue Toe Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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