MCID: BLT003
MIFTS: 38

Blue Toe Syndrome

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Blue Toe Syndrome

MalaCards integrated aliases for Blue Toe Syndrome:

Name: Blue Toe Syndrome 12 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:14121
MeSH 45 D018438
UMLS 74 C0242645

Summaries for Blue Toe Syndrome

MalaCards based summary : Blue Toe Syndrome is related to disseminated intravascular coagulation and cholesterol embolism. An important gene associated with Blue Toe Syndrome is ARG1 (Arginase 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Acetylcholine and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and bone marrow, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 77 Blue toe syndrome is a situation that may reflect atherothrombotic microembolism, causing transient... more...

Related Diseases for Blue Toe Syndrome

Diseases related to Blue Toe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 166, show less)
# Related Disease Score Top Affiliating Genes
1 disseminated intravascular coagulation 29.5 F2 F3 SERPINC1 SERPINE1
2 cholesterol embolism 11.3
3 spinal cord infarction 10.3 F2 SERPINC1
4 prothrombin deficiency, congenital 10.3 F2 SERPINC1
5 sneddon syndrome 10.3 F2 SERPINC1
6 malignant otitis externa 10.3 CRP F2
7 esophageal varix 10.3 F2 SERPINC1
8 japanese spotted fever 10.3 CRP SERPINC1
9 fibrinolytic defect 10.3 SERPINC1 SERPINE1
10 chronic thromboembolic pulmonary hypertension 10.3 CRP F2
11 lipid pneumonia 10.3 ARG1 CRP
12 abdominal tuberculosis 10.3 CRP F2
13 antithrombin iii deficiency 10.3 F2 SERPINC1
14 hypersplenism 10.3 F2 SERPINC1
15 aspirin allergy 10.3 SERPINC1 SERPINE1
16 ischemic neuropathy 10.3 CRP F2
17 argentine hemorrhagic fever 10.3 SERPINC1 SERPINE1
18 central retinal vein occlusion 10.3 F2 SERPINC1
19 sticky platelet syndrome 10.3 SERPINC1 SERPINE1
20 dysfibrinogenemia 10.2 F2 SERPINC1
21 ischemic optic neuropathy 10.2 F2 SERPINC1
22 cryptogenic cirrhosis 10.2 F2 SERPINE1
23 meningococcemia 10.2 SERPINC1 SERPINE1
24 heparin-induced thrombocytopenia 10.2 F3 SERPINC1
25 hemophilia 10.2 F2 F3
26 placental abruption 10.2 F2 SERPINC1
27 afibrinogenemia 10.2 F2 F3
28 angina pectoris 10.2 CRP SERPINC1
29 prothrombin deficiency 10.2 F2 F3
30 protein c deficiency 10.2 F2 SERPINC1
31 cerebral sinovenous thrombosis 10.2 F2 F3
32 legg-calve-perthes disease 10.2 SERPINC1 SERPINE1
33 posterior myocardial infarction 10.2 PCLAF SERPINC1
34 arteritic anterior ischemic optic neuropathy 10.2 CRP F2
35 qualitative platelet defect 10.2 F2 F3
36 buerger disease 10.2 F2 SERPINE1
37 nonarteritic anterior ischemic optic neuropathy 10.2 F2 SERPINC1
38 alcohol-related birth defect 10.2 F2 F3
39 hantavirus pulmonary syndrome 10.2 F2 F3
40 von willebrand disease, type 1 10.2 F2 F3
41 vascular hemostatic disease 10.2 F2 F3
42 splenic disease 10.2 F2 F3
43 factor xii deficiency 10.2 F3 SERPINC1
44 epileptic encephalopathy, childhood-onset 10.2 SERPINC1 SERPINE1
45 pulmonary immaturity 10.2 F3 SERPINC1
46 leptospirosis 10.2 CRP F2
47 catastrophic antiphospholipid syndrome 10.1 F3 SERPINE1
48 carotid artery thrombosis 10.1 F3 SERPINE1
49 squamous cell papilloma 10.1 F2 F3
50 scrub typhus 10.1 CRP F3
51 factor xiii deficiency 10.1 F3 SERPINE1
52 thrombasthenia 10.1 F2 F3
53 typhoid fever 10.1 CRP F2
54 endocarditis 10.1 CRP F2 SERPINC1
55 factor vii deficiency 10.1 F2 F3
56 carotid artery dissection 10.1 ARG1 PLG
57 tuberculous empyema 10.1 PLG SERPINE1
58 homocysteinemia 10.1 CRP F2 SERPINC1
59 placental insufficiency 10.1 F2 F3
60 ischemic colitis 10.1 F2 SERPINC1 SERPINE1
61 subendocardial myocardial infarction 10.1 F2 SERPINC1 SERPINE1
62 osteonecrosis 10.1 F2 SERPINC1 SERPINE1
63 thrombophlebitis 10.1 F2 SERPINC1 SERPINE1
64 conjugate gaze palsy 10.1 F3 PLG
65 adult respiratory distress syndrome 10.1 F2 SERPINE1
66 post-thrombotic syndrome 10.1 F2 SERPINC1 SERPINE1
67 acute cor pulmonale 10.1 PLG SERPINE1
68 posterolateral myocardial infarction 10.1 PCLAF PLG
69 factor v deficiency 10.1 F2 F3
70 lateral myocardial infarction 10.1 PCLAF PLG
71 retinal artery occlusion 10.1 F2 SERPINC1 SERPINE1
72 portal vein thrombosis 10.1 F2 SERPINC1 SERPINE1
73 retinal vein occlusion 10.1 F2 SERPINC1 SERPINE1
74 acute pulmonary heart disease 10.1 PLG SERPINE1
75 von willebrand's disease 10.1 F2 F3
76 erysipeloid 10.1 PCLAF PLG
77 fournier gangrene 10.0 F2 F3 SERPINC1
78 sagittal sinus thrombosis 10.0 F2 F3 SERPINC1
79 marantic endocarditis 10.0 F2 F3 SERPINC1
80 retinoblastoma 10.0
81 purpura fulminans 10.0 F2 F3 SERPINC1
82 hepatic infarction 10.0 F2 F3 SERPINC1
83 obstructive jaundice 10.0 CRP F2
84 inherited blood coagulation disease 10.0 F2 F3 SERPINC1
85 blood protein disease 10.0 F2 F3 SERPINC1
86 branch retinal artery occlusion 10.0 F2 F3 SERPINC1
87 factor xi deficiency 10.0 F2 F3 SERPINC1
88 protein s deficiency 10.0 F2 F3 SERPINC1
89 venous insufficiency 10.0 CRP F2 SERPINE1
90 vertebral artery occlusion 10.0 F3 PLG
91 infective endocarditis 10.0 CRP F2 SERPINE1
92 hemophilia b 10.0 F2 F3 SERPINC1
93 factor x deficiency 10.0 F2 F3 SERPINC1
94 afibrinogenemia, congenital 10.0 F2 F3 SERPINC1
95 budd-chiari syndrome 10.0 F2 F3 SERPINC1
96 blood platelet disease 10.0 F2 F3 SERPINC1
97 antiphospholipid syndrome 10.0 F2 F3 SERPINC1
98 dengue hemorrhagic fever 10.0 F2 F3
99 coronary stenosis 10.0 CRP SERPINE1
100 cerebrovascular disease 10.0 CRP F2 SERPINE1
101 analbuminemia 10.0 CRP F2 F3
102 heart conduction disease 10.0 CRP F2 PCLAF
103 alpha-2-plasmin inhibitor deficiency 10.0 F2 PLG SERPINC1
104 intracranial embolism 10.0 F2 PLG SERPINC1
105 coronary thrombosis 10.0 F3 SERPINC1 SERPINE1
106 liver cirrhosis 10.0 F2 F3 SERPINC1
107 retinal vascular occlusion 10.0 F2 PLG SERPINC1
108 anterior spinal artery syndrome 10.0 F2 PLG SERPINC1
109 placenta disease 10.0 F3 SERPINC1
110 essential thrombocythemia 9.9 F2 F3 SERPINE1
111 arteriosclerosis 9.9 CRP F3 SERPINE1
112 intracranial thrombosis 9.9 F3 PLG SERPINC1
113 cryoglobulinemia, familial mixed 9.9
114 scleroderma, familial progressive 9.9
115 glomerulonephritis 9.9
116 locked-in syndrome 9.9
117 polyclonal hypergammaglobulinemia 9.9
118 acute pancreatitis 9.9
119 cryoglobulinemia 9.9
120 rapidly progressive glomerulonephritis 9.9
121 pancreatitis 9.9
122 polyarteritis nodosa 9.9
123 bone marrow necrosis 9.9
124 cutaneous polyarteritis nodosa 9.9
125 hemangioendothelioma 9.9
126 epithelioid hemangioendothelioma 9.9
127 cerebral falx meningioma 9.9 F2 F3 PLG
128 femoral neuropathy 9.9 F2 F3 PLG
129 anterior cranial fossa meningioma 9.9 F2 F3 PLG
130 intermittent claudication 9.8 CRP F2 SERPINC1 SERPINE1
131 dysbaric osteonecrosis 9.8 F3 PLG SERPINE1
132 pulmonary edema 9.8 CRP F2
133 peripheral vertigo 9.8 CRP F2 F3 SERPINC1
134 thrombocytosis 9.8 CRP F2 F3 SERPINC1
135 purpura 9.8 CRP F2 F3 SERPINC1
136 carotid artery disease 9.8 CRP PLG
137 thrombophilia 9.8 F2 F3 SERPINC1 SERPINE1
138 intracranial hypertension 9.8 F2 F3 SERPINC1 SERPINE1
139 thrombophilia due to thrombin defect 9.8 F2 F3 SERPINC1 SERPINE1
140 hemorrhagic disease 9.8 F2 F3 SERPINC1 SERPINE1
141 hellp syndrome 9.8 F2 F3 SERPINC1 SERPINE1
142 thrombosis 9.8 F2 F3 SERPINC1 SERPINE1
143 pre-eclampsia 9.8 F2 F3 SERPINC1 SERPINE1
144 livedoid vasculitis 9.7 F2 PLG SERPINC1 SERPINE1
145 leech infestation 9.7 F2 F3 PLG SERPINC1
146 intestinal impaction 9.7 F2 F3 PLG SERPINC1
147 giant hemangioma 9.7 F2 F3 PLG SERPINC1
148 korean hemorrhagic fever 9.7 F2 F3 PLG SERPINC1
149 pulmonary artery disease 9.7 F2 F3 PLG SERPINC1
150 blood coagulation disease 9.7 F2 F3 PLG SERPINC1
151 coronary artery anomaly 9.7 CRP F2 PLG SERPINE1
152 intermediate coronary syndrome 9.7 CRP F3 PLG SERPINC1
153 endocardium disease 9.7 CRP F2 F3 PLG
154 hepatic veno-occlusive disease 9.6 F3 PLG SERPINC1 SERPINE1
155 lemierre's syndrome 9.6 CRP F3 PLG SERPINE1
156 pulmonary embolism 9.6 CRP F2 F3 SERPINC1 SERPINE1
157 peripheral vascular disease 9.6 CRP F2 F3 SERPINC1 SERPINE1
158 heart disease 9.5 CRP F2 F3 SERPINC1 SERPINE1
159 hepatic vascular disease 9.4 F2 F3 PLG SERPINC1 SERPINE1
160 vein disease 9.4 F2 F3 PLG SERPINC1 SERPINE1
161 thrombophilia due to activated protein c resistance 9.4 F2 F3 PLG SERPINC1 SERPINE1
162 arteries, anomalies of 9.4 CRP F3 PLG SERPINC1 SERPINE1
163 acute myocardial infarction 9.4 CRP F3 PLG SERPINC1 SERPINE1
164 vascular disease 9.2 CRP F2 F3 PLG SERPINC1 SERPINE1
165 stroke, ischemic 9.2 CRP F2 F3 PLG SERPINC1 SERPINE1
166 myocardial infarction 9.2 CRP F2 F3 PLG SERPINC1 SERPINE1

Graphical network of the top 20 diseases related to Blue Toe Syndrome:



Diseases related to Blue Toe Syndrome

Symptoms & Phenotypes for Blue Toe Syndrome

MGI Mouse Phenotypes related to Blue Toe Syndrome:

47 (showing 4, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 CRP F2 F3 PLG SERPINC1 SERPINE1
2 hematopoietic system MP:0005397 9.7 ARG1 F2 F3 PCLAF PLG SERPINC1
3 homeostasis/metabolism MP:0005376 9.56 ARG1 CRP F2 F3 PLG RBMS1
4 immune system MP:0005387 9.23 ARG1 CRP F2 F3 PCLAF PLG

Drugs & Therapeutics for Blue Toe Syndrome

Drugs for Blue Toe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 11, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2 Peripheral Nervous System Agents Phase 4
3 Botulinum Toxins, Type A Phase 4
4 Neurotransmitter Agents Phase 4
5 Acetylcholine Release Inhibitors Phase 4
6 Arginine Vasopressin Phase 4
7 Neuromuscular Agents Phase 4
8 Vasopressins Phase 4
9 abobotulinumtoxinA Phase 4
10 Cholinergic Agents Phase 4
11 Botulinum Toxins Phase 4

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Botulinum Toxin A for Treatment of Catocholamine Induced Finger Necrosis Unknown status NCT01500668 Phase 4 Botox;Placebo

Search NIH Clinical Center for Blue Toe Syndrome

Cochrane evidence based reviews: blue toe syndrome

Genetic Tests for Blue Toe Syndrome

Anatomical Context for Blue Toe Syndrome

MalaCards organs/tissues related to Blue Toe Syndrome:

42
Bone, Heart, Bone Marrow, Skin, Liver, Spinal Cord, Placenta

Publications for Blue Toe Syndrome

Articles related to Blue Toe Syndrome:

(showing 60, show less)
# Title Authors Year
1
Blue toe syndrome as a first sign of systemic sclerosis. ( 29305361 )
2018
2
Blue toe syndrome in cutaneous polyarteritis nodosa. ( 29534226 )
2018
3
The usefulness of Duplex Doppler ultrasound in the angiological and dermatological diagnosis of patients with blue toe syndrome. ( 29507564 )
2017
4
Blue Toe Syndrome as an Early Sign of Disseminated Intravascular Coagulation. ( 27274647 )
2016
5
A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome. ( 25534490 )
2015
6
Blue toe syndrome, ischemic pain treated with digital block. ( 25605677 )
2015
7
Blue toe syndrome: a complication of intra-arterial technique, not intra-arterial chemotherapy for retinoblastoma. ( 24810697 )
2014
8
Blue toe syndrome--reply. ( 24810698 )
2014
9
Skin lesions simulating blue toe syndrome caused by prolonged contact with a millipede. ( 24861307 )
2014
10
Blue toe syndrome as a complication of intra-arterial chemotherapy for retinoblastoma. ( 23764710 )
2013
11
Coil embolization of persistent sciatic artery pseudoaneurysm presenting as blue toe syndrome, a rare case. ( 24426603 )
2013
12
Blue toe syndrome treated with sympathectomy in a patient with acute renal failure caused by cholesterol embolization. ( 26877940 )
2013
13
Compression of the dorsalis pedis artery: a novel cause of blue toe syndrome. ( 22983548 )
2012
14
Blue toe syndrome and sunitinib. ( 21136131 )
2011
15
Epithelioid hemangioendothelioma as a rare cause of blue toe syndrome. ( 21571496 )
2011
16
Isolated blue toe syndrome as the initial sign of Wegener granulomatosis. ( 20609674 )
2010
17
Locked-in Syndrome and Blue Toe Syndrome Caused by Cardiopulmonary Bypass. ( 23074585 )
2010
18
Blue toe syndrome as a clue to the underlying cause of acute renal failure. ( 25949485 )
2010
19
Blue toe syndrome. ( 17906493 )
2007
20
Spontaneous dissection of the popliteal artery in a young man. A rare cause of the blue toe syndrome. ( 16520732 )
2006
21
Renal failure associated with blue toe syndrome: effective treatment with intravenous prostaglandin E-1. ( 16874430 )
2006
22
Blue toe syndrome: a rare complication of acute pancreatitis. ( 12555011 )
2003
23
Case report: Blue toe syndrome caused by a true crural aneurysm. ( 12813416 )
2003
24
Angioplasty with stenting is effective in treating blue toe syndrome. ( 11951102 )
2002
25
A vitamin K antagonist rapidly reverses a blue toe syndrome in a patient with lupus anticoagulant and antiprothrombin antibodies. ( 12152242 )
2002
26
Atheroembolic signals detected by Doppler ultrasound scan monitoring in a patient with blue toe syndrome: report of a case. ( 12376800 )
2002
27
The blue toe syndrome during oral anticoagulant therapy with acenocoumarol. ( 11341514 )
2001
28
Blue toe syndrome: treatment with intra-arterial stents and review of therapies. ( 10834489 )
2000
29
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. ( 11399611 )
2000
30
Special exhibit for the SCVIR Annual Meeting Film Panel Session: diagnosis and discussion of cases 5-8. Society of Cardiovascular & Interventional Radiology. Case 6. Blue-toe syndrome secondary to embolization from a complex right common iliac artery plaque containing fresh thrombus material. ( 10498409 )
1999
31
Blue toe syndrome after initiation of low-dose oral anticoagulation. ( 9620888 )
1998
32
Blue toe syndrome associated with rapidly progressive glomerulonephritis: ultimately revealed essential mixed cryoglobulinemia. ( 9044465 )
1997
33
Evaluation and management of cholesterol embolization and the blue toe syndrome. ( 8889381 )
1996
34
Transesophageal echocardiographic findings in blue toe syndrome exacerbated by anticoagulation. ( 8943451 )
1996
35
Additional causes of the blue toe syndrome. ( 7791402 )
1995
36
Blue toe syndrome from a "coral reef" aorta. ( 8746834 )
1995
37
Femoral artery hypoplasia and persistent sciatic artery with blue toe syndrome: a case report, histologic analysis and review of the literature. ( 7963875 )
1994
38
External iliac ligation and axillary-bifemoral bypass for blue toe syndrome. ( 8284757 )
1994
39
Reversal of gangrenous lesions in the blue toe syndrome with lovastatin--a case report. ( 8214780 )
1993
40
The "blue-toe" syndrome as a harbinger of impending infrainguinal vein graft failure: a report of three cases. ( 8268072 )
1993
41
Blue toe syndrome. Causes and management. ( 1444678 )
1992
42
Atherectomy of the distal aorta using a "kissing-balloon" technique for the treatment of blue toe syndrome. ( 1535174 )
1992
43
Blue toe syndrome. ( 1747352 )
1991
44
Corticosteroid-associated blue toe syndrome: role of antiphospholipid antibodies. ( 2240906 )
1990
45
Atherothrombotic microembolism of the lower extremities (the blue toe syndrome) from atherosclerotic non-aneurysmal aortic plaques. ( 2324190 )
1990
46
Blue toe syndrome: treatment with percutaneous atherectomy. ( 2813788 )
1989
47
Blue toe syndrome: treatment with anticoagulants and delayed percutaneous transluminal angioplasty. ( 2962224 )
1988
48
Digital arterial embolism-true blue toe syndrome. A histopathologic analysis. ( 3246660 )
1988
49
The blue toe syndrome: hemodynamics and therapeutic correlates of outcome. ( 3512857 )
1986
50
Primary thrombocythemia: another cause of the "blue toe syndrome". ( 3711871 )
1986
51
Blue toe syndrome. ( 3716963 )
1986
52
The "blue toe" syndrome with renal atheroembolism and failure. ( 4025934 )
1985
53
Dilemmas in dealing with the blue toe syndrome: aortic versus peripheral source. ( 6507759 )
1984
54
Blue toe syndrome--a warning sign of unsuspected vascular injury. ( 6221428 )
1983
55
Blue toe syndrome. A case presentation. ( 6655197 )
1983
56
Experience with the Blue Toe Syndrome. ( 7076462 )
1982
57
Blue toe syndrome. ( 7108117 )
1982
58
Bilateral blue toe syndrome. A case report. ( 7351752 )
1980
59
Sudden ischemic toe: "the blue toe syndrome". ( 695883 )
1978
60
"Blue toe" syndrome. An indication for limb salvage surgery. ( 985075 )
1976

Variations for Blue Toe Syndrome

Expression for Blue Toe Syndrome

Search GEO for disease gene expression data for Blue Toe Syndrome.

Pathways for Blue Toe Syndrome

GO Terms for Blue Toe Syndrome

Cellular components related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

(showing 4, show less)
# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ARG1 CRP F2 F3 PLG SERPINC1
2 collagen-containing extracellular matrix GO:0062023 9.46 F3 PLG SERPINC1 SERPINE1
3 blood microparticle GO:0072562 9.43 F2 PLG SERPINC1
4 extracellular space GO:0005615 9.17 ARG1 CRP F2 F3 PLG SERPINC1

Biological processes related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

(showing 8, show less)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.58 F2 PLG SERPINC1
2 blood coagulation GO:0007596 9.56 F2 F3 PLG SERPINC1
3 acute-phase response GO:0006953 9.43 CRP F2
4 positive regulation of blood coagulation GO:0030194 9.37 F2 SERPINE1
5 fibrinolysis GO:0042730 9.33 F2 PLG SERPINE1
6 regulation of blood coagulation GO:0030193 9.32 F2 SERPINC1
7 negative regulation of fibrinolysis GO:0051918 9.13 F2 PLG SERPINE1
8 hemostasis GO:0007599 8.92 F2 F3 PLG SERPINC1

Molecular functions related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.81 ARG1 CRP F2 F3 PCLAF PLG
2 serine-type endopeptidase activity GO:0004252 9.13 F2 F3 PLG
3 protease binding GO:0002020 8.8 F3 SERPINC1 SERPINE1

Sources for Blue Toe Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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