Body Dysmorphic Disorder disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BDY001 MIFTS: 42	Body Dysmorphic Disorder Categories: Mental diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Download Expand all tables

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Aliases & Classifications for Body Dysmorphic Disorder

MalaCards integrated aliases for Body Dysmorphic Disorder:

Name: Body Dysmorphic Disorder ¹² ⁷⁶ ³⁷ ¹⁵

Dysmorphophobia ¹² ⁷⁶

Body Dysmorphic Disorders ⁷³

Dysmorphic Syndrome ¹²

Body Dysmorphia ¹²

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060163

KEGG ³⁷ H01447

UMLS ⁷³ C0005887

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Summaries for Body Dysmorphic Disorder

Disease Ontology : ¹² A somatoform disorder that involves an excessive concern about and preoccupation with a perceived defect in his or her physical features (body image).

MalaCards based summary : Body Dysmorphic Disorder, also known as dysmorphophobia, is related to hypoparathyroidism-retardation-dysmorphism syndrome and birk-barel mental retardation dysmorphism syndrome. An important gene associated with Body Dysmorphic Disorder is SLITRK1 (SLIT And NTRK Like Family Member 1), and among its related pathways/superpathways are Serotonergic synapse and Metabolism of water-soluble vitamins and cofactors. The drugs Piracetam and Fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and skin.

Wikipedia : ⁷⁶ Body dysmorphic disorder (BDD), occasionally still called dysmorphophobia, is a mental disorder... more...

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Related Diseases for Body Dysmorphic Disorder

Diseases related to Body Dysmorphic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)

#	Related Disease	Score
1	hypoparathyroidism-retardation-dysmorphism syndrome	12.2
2	birk-barel mental retardation dysmorphism syndrome	12.2
3	macrocephaly, macrosomia, and facial dysmorphism syndrome	12.1
4	hypoparathyroidism-intellectual disability-dysmorphism syndrome	12.0
5	aids dysmorphic syndrome	11.9
6	choanal atresia-hearing loss-cardiac defects-craniofacial dysmorphism syndrome	11.9
7	intellectual disability-severe speech delay-mild dysmorphism syndrome	11.9
8	night blindness-skeletal anomalies-dysmorphism syndrome	11.7
9	hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome	11.7
10	intellectual disability-expressive aphasia-facial dysmorphism syndrome	11.7
11	congenital labioscrotal agenesis-cerebellar malformation-corneal dystrophy-facial dysmorphism syndrome	11.7
12	thin ribs-tubular bones-dysmorphism syndrome	11.7
13	short stature-deafness-neutrophil dysfunction-dysmorphism syndrome	11.7
14	intellectual disability-obesity-brain malformations-facial dysmorphism syndrome	11.7
15	intellectual disability-muscle weakness-short stature-facial dysmorphism syndrome	11.7
16	microcephaly-short stature-intellectual disability-facial dysmorphism syndrome	11.7
17	x-linked external auditory canal atresia-dilated internal auditory canal-facial dysmorphism syndrome	11.7
18	metopic ridging-ptosis-facial dysmorphism syndrome	11.7
19	osteopenia-myopia-hearing loss-intellectual disability-facial dysmorphism syndrome	11.7
20	x-linked intellectual disability-epilepsy-progressive joint contractures-dysmorphism syndrome	11.7
21	arachnodactyly - intellectual disability - dysmorphism	11.3
22	kcnk9 imprinting syndrome	11.2
23	xia-gibbs syndrome	11.2
24	culler-jones syndrome	10.8
25	epileptic encephalopathy, early infantile, 23	10.8
26	short stature, hearing loss, retinitis pigmentosa, and distinctive facies	10.8
27	fibromatosis, gingival, with distinctive facies	10.6
28	hirschsprung disease with hypoplastic nails and dysmorphic facial features	10.6
29	spinocerebellar ataxia with dysmorphism	10.6
30	cubitus valgus with mental retardation and unusual facies	10.6
31	fryns macrocephaly	10.6
32	dislocation of hip, congenital, with hyperextensibility of fingers and facial dysmorphism	10.6
33	spondylometaphyseal dysplasia with bowed forearms and facial dysmorphism	10.6
34	burn-mckeown syndrome	10.6
35	mental retardation with language impairment and with or without autistic features	10.6
36	beaulieu-boycott-innes syndrome	10.6
37	steel syndrome	10.6
38	mental retardation, autosomal recessive 39	10.6
39	mental retardation, autosomal dominant 23	10.6
40	tatton-brown-rahman syndrome	10.6
41	mental retardation, autosomal dominant 36	10.6
42	klippel-feil syndrome 4, autosomal recessive, with nemaline myopathy and facial dysmorphism	10.6
43	mental retardation and distinctive facial features with or without cardiac defects	10.6
44	epiphyseal dysplasia hearing loss dysmorphism	10.6
45	med13l haploinsufficiency syndrome	10.6
46	reunion island larsen syndrome	10.6
47	cono-spondylar dysplasia	10.6
48	acromegaloid facial appearance syndrome	10.6
49	elsahy-waters syndrome	10.6
50	atelosteogenesis, type ii	10.6

Graphical network of the top 20 diseases related to Body Dysmorphic Disorder:

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Symptoms & Phenotypes for Body Dysmorphic Disorder

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Drugs & Therapeutics for Body Dysmorphic Disorder

Drugs for Body Dysmorphic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Piracetam

Approved, Investigational

Phase 4

7491-74-9

Fluoxetine

Approved, Vet_approved

Phase 4

54910-89-3

3386

Norepinephrine

Approved

Phase 4

51-41-2

439260

Etiracetam

Investigational

Phase 4

33996-58-6

Serotonin Agents

Phase 4,Phase 3,Phase 2

Serotonin Uptake Inhibitors

Phase 4,Phase 3,Phase 2

Neuroprotective Agents

Phase 4

Neurotransmitter Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Neurotransmitter Uptake Inhibitors

Phase 4,Phase 3,Phase 2

Cytochrome P-450 CYP2D6 Inhibitors

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Nootropic Agents

Phase 4

Anticonvulsants

Phase 4

Antidepressive Agents

Phase 4,Phase 3

Antidepressive Agents, Second-Generation

Phase 4,Phase 3

Protective Agents

Phase 4,Phase 2

Psychotropic Drugs

Phase 4,Phase 3,Phase 2

Serotonin and Noradrenaline Reuptake Inhibitors

Phase 4

Venlafaxine Hydrochloride

Phase 4

Serotonin

Investigational, Nutraceutical

Phase 4,Phase 3,Phase 2

50-67-9

5202

Citalopram

Approved

Phase 3

59729-33-8

2771

Cholinergic Agents

Phase 3

Muscarinic Antagonists

Phase 3

Cholinergic Antagonists

Phase 3

Parasympatholytics

Phase 3

Peripheral Nervous System Agents

Phase 3,Phase 2,Not Applicable

Antiparkinson Agents

Phase 3,Not Applicable

Autonomic Agents

Phase 3,Phase 2

Oxytocin

Approved, Vet_approved

Phase 2

50-56-6

439302 53477758

Ondansetron

Approved

Phase 2

99614-02-5

4595

Lactitol

Investigational

Phase 2

585-86-4

3871

Hormones

Phase 2

Oxytocics

Phase 2

Central Nervous System Depressants

Phase 2,Not Applicable

Antioxidants

Phase 2

Serotonin Antagonists

Phase 2

Gastrointestinal Agents

Phase 2

Dermatologic Agents

Phase 2

Tranquilizing Agents

Phase 2

Anti-Anxiety Agents

Phase 2

Antiemetics

Phase 2

Antipruritics

Phase 2

Antipsychotic Agents

Phase 2

silymarin

Nutraceutical

Phase 2

Milk Thistle

Nutraceutical

Phase 2

Memantine

Approved, Investigational

Not Applicable

19982-08-2

4054

Dopamine

Approved

Not Applicable

51-61-6, 62-31-7

681

Cocaine

Approved, Illicit

Not Applicable

50-36-2

5760 446220

Cycloserine

Approved

Early Phase 1

68-41-7

401 6234

Diprenorphine

Illicit, Vet_approved

Not Applicable

14357-78-9

Interventional clinical trials:

(show all 34)

#	Name	Status	NCT ID	Phase	Drugs
1	Effectiveness of Levetiracetam in the Treatment of Body Dysmorphic Disorder	Completed	NCT00265109	Phase 4	Levetiracetam
2	Fluoxetine in Pediatric Body Dysmorphic Disorder	Completed	NCT00245635	Phase 4	Fluoxetine;Placebo
3	CBT as an Adjunct to SRIs in the Treatment of BDD	Terminated	NCT00211809	Phase 4	Venlafaxine
4	Effectiveness of Escitalopram in the Treatment of Body Dysmorphic Disorder	Completed	NCT00149799	Phase 3	Escitalopram;Placebo
5	Study of Patients With Body Image Issues Treated With 2 Different Behavioral Interventions	Unknown status	NCT01316627	Phase 2
6	Oxytocin Administration in BDD and OCD	Completed	NCT02671266	Phase 2	Oxytocin;Placebo
7	Milk Thistle in Body Dysmorphic Disorder	Recruiting	NCT02843451	Phase 2	Milk Thistle;Placebo
8	Efficacy and Safety Study of Low-Dose Ondansetron For Adjunctive Therapy In Adult Patients With Obsessive-Compulsive Disorder	Terminated	NCT01275248	Phase 2	Ondansetron;Placebo
9	Cognitive-Behavioral Therapy and Supportive Psychotherapy for Body Dysmorphic Disorder	Unknown status	NCT01453439	Not Applicable
10	Body Image and Self-Care in HIV-Infected MSM	Unknown status	NCT01817621	Not Applicable
11	Attentional Bias in Body Dysmorphic Disorder	Completed	NCT01398904
12	Internet Cognitive Behavior Therapy (CBT) for Body Dysmorphic Disorder (BDD)	Completed	NCT01850433	Not Applicable
13	Treatment Study Investigating New Cognitive Behavioral Therapy Treatment Manual for Body Dysmorphic Disorder	Completed	NCT00106223	Not Applicable
14	Cognitive-Behavioral Therapy for Pediatric Body Dysmorphic Disorder	Completed	NCT01002326	Not Applicable
15	Internet Delivered CBT for Body Dysmorphic Disorder	Completed	NCT02010619	Not Applicable
16	An Open Label Trial of Memantine in the Treatment of Bulimia Nervosa and Body Dysmorphic Disorder	Completed	NCT01038128	Not Applicable	Memantine
17	Cognitive Behaviour Therapy (CBT) for Body Dysmorphic Disorder (BDD)	Completed	NCT00871143	Not Applicable
18	Escitalopram Neuroimaging Supplement	Completed	NCT01398865
19	Assessment of Body Image in Patients With Rheumatoid Arthritis	Completed	NCT00832910
20	Effectiveness of Dance on Patients With Fibromyalgia	Completed	NCT00961805	Not Applicable
21	Impairment of Central Coherence in Restrictive Anorexia Nervosa (CoCA)	Completed	NCT02381639	Not Applicable
22	Cortical Excitability in Obsessive-Compulsive and Related Disorders	Completed	NCT00029068
23	Smartphone-Administered App Treatment for Adults With Body Dysmorphic Disorder	Recruiting	NCT03221738	Not Applicable
24	Contribution of a Virtual Reality Program in the Treatment of Dysmorphophobia for Adolescent Female With Anorexia Nervosa	Recruiting	NCT03426930	Not Applicable
25	Body Image Disorder in Anorexia Nervosa and Virtual Reality	Recruiting	NCT03118921	Not Applicable
26	Brain Correlates of Self-Focused Processing	Recruiting	NCT02808702	Not Applicable
27	White Light Scanning to Aid Body Contouring: A Pilot Project	Recruiting	NCT01093950
28	Evaluation of Brain Opioid Receptor Activity in Anorexia Nervosa : a PET [11C]Diprenorphine Study	Recruiting	NCT02524301	Not Applicable	Positron Emission Tomography using [11C]diprenorphine
29	The Pride Body Project	Recruiting	NCT03451513	Not Applicable
30	Feasibility Pilot Study of Internet-based Cognitive Behavioral Therapy (CBT) for Body Dysmorphic Disorder With Global Recruitment	Active, not recruiting	NCT03517384	Not Applicable
31	Interpretation Bias Modification for Body Dysmorphic Disorder	Active, not recruiting	NCT02635152	Not Applicable
32	D-Cycloserine Augmentation of Behavior Therapy for Individuals With Body Dysmorphic Disorder	Active, not recruiting	NCT00842309	Early Phase 1	d-cycloserine;Placebo
33	Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals	Active, not recruiting	NCT01075672	Not Applicable
34	Benefits of a Psychoeducation Program for Those Awaiting Treatment for OCD and OCD Spectrum Disorders	Suspended	NCT01953042	Not Applicable

Search NIH Clinical Center for Body Dysmorphic Disorder

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Genetic Tests for Body Dysmorphic Disorder

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Anatomical Context for Body Dysmorphic Disorder

MalaCards organs/tissues related to Body Dysmorphic Disorder:

⁴¹

Brain, Eye, Skin, Breast, Testes, Bone

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Publications for Body Dysmorphic Disorder

Articles related to Body Dysmorphic Disorder:

(show top 50) (show all 545)

#	Title	Authors	Year
1	Shame and Defectiveness Beliefs in Treatment Seeking Patients With Body Dysmorphic Disorder. ( 29557815 )	Weingarden H....Wilhelm S.	2018
2	Escalation from normal appearance related intrusive cognitions to clinical preoccupations in Body Dysmorphic Disorder: A cross-sectional study. ( 29704773 )	Giraldo-O'Meara M....Belloch A.	2018
3	New perspectives in the treatment of body dysmorphic disorder. ( 29636904 )	Hong K....Hollander E.	2018
4	A systematic review and meta-analysis of cognitive processing deficits associated with body dysmorphic disorder. ( 29935380 )	Johnson S....Wade T.D.	2018
5	Patients Screening Positive for Body Dysmorphic Disorder Show No Significant Health-Related Quality of Life Gain after Functional Septorhinoplasty at a Tertiary Referral Center. ( 29702720 )	Bulut O.C....Hohenberger R.	2018
6	Body dysmorphic disorder: a guide to identification and management for the orthodontic team. ( 29952250 )	Rosten A....Newton J.T.	2018
7	The classification of body dysmorphic disorder symptoms in male and female adolescents. ( 28858657 )	Schneider S.C....Hudson J.L.	2018
8	Non-weight-related body image concerns and Body Dysmorphic Disorder prevalence in patients with Anorexia Nervosa. ( 29886274 )	Cerea S....Ghisi M.	2018
9	Pharmacological Treatment Of Body Dysmorphic Disorder. ( 29701157 )	Hong K....Hollander E.	2018
10	Body dysmorphic disorder in the cosmetic practice. ( 29667794 )	Kuhn H....Kroumpouzos G.	2018
11	Cosmetic Surgery and Body Dysmorphic Disorder - An Update. ( 29872676 )	Higgins S....Wysong A.	2018
12	Validation of Spanish Language Evaluation Instruments for Body Dysmorphic Disorder and the Dysmorphic Concern Construct. ( 28713311 )	SenA-n-CalderA^n C....RodrA-guez-Testal J.F.	2017
13	The neurobiology of body dysmorphic disorder: A systematic review and theoretical model. ( 29017915 )	Grace S.A....Rossell S.L.	2017
14	Prevalence of body dysmorphic disorder and associated features in German adolescents: A self-report survey. ( 28482195 )	MAPllmann A....Buhlmann U.	2017
15	Evaluation of the Body Parts That Preoccupy Adolescents With Body Dysmorphic Disorder. ( 29099545 )	Jafferany M....Osuagwu F.C.	2017
16	Neurocognitive Functioning in Young Adults with Subclinical Body Dysmorphic Disorder. ( 28367586 )	Blum A.W....Grant J.E.	2017
17	Long-Term Outcomes of Cognitive-Behavioral Therapy for Adolescent Body Dysmorphic Disorder. ( 28577583 )	Krebs G....Mataix-Cols D.	2017
18	Body dysmorphic disorder: A serious concern for our young generation. ( 28784390 )	Jangda A.A....Shah S.R.	2017
19	Insight in body dysmorphic disorder (BDD) relative to obsessive-compulsive disorder (OCD) and psychotic disorders: Revisiting this issue in light of DSM-5. ( 28651226 )	Toh W.L....Rossell S.L.	2017
20	Face and Object Perception in Body Dysmorphic Disorder versus Obsessive-Compulsive Disorder: The Mooney Faces Task. ( 28528596 )	Toh W.L....Rossell S.L.	2017
21	[Body dysmorphic disorder : Diagnostics and treatment in cosmetic dermatology]. ( 29075869 )	Lahousen T....Gieler U.	2017
22	How individuals with body dysmorphic disorder (BDD) process their own face: a quantitative and qualitative investigation based on an eye-tracking paradigm. ( 28322616 )	Toh W.L....Rossell S.L.	2017
23	Body Dysmorphic Disorder in Patients With Autism Spectrum Disorder: A Reflection of Increased Local Processing and Self-Focus. ( 28366095 )	Vasudeva S.B....Hollander E.	2017
24	Prevalence of Body Dysmorphic Disorder in Plastic Surgery and Dermatology Patients: A Systematic Review with Meta-Analysis. ( 28411353 )	Ribeiro R.V.E.	2017
25	Body dysmorphic disorder in female Swedish dermatology patients. ( 28960272 )	Brohede S....Wijma K.	2017
26	A multi-method analysis of distress tolerance in body dysmorphic disorder. ( 28826046 )	Matheny N.L....Cougle J.R.	2017
27	Patient-identified events implicated in the development of body dysmorphic disorder. ( 28285175 )	Weingarden H....Wilhelm S.	2017
28	Visual selective attention in body dysmorphic disorder, bulimia nervosa and healthy controls. ( 27998509 )	Kollei I....Martin A.	2017
29	'Not just right' experiences and incompleteness in body dysmorphic disorder. ( 27918970 )	Summers B.J....Cougle J.R.	2017
30	Selfie use: The implications for psychopathology expression of body dysmorphic disorder. ( 29456333 )	Khanna A....Sharma M.K.	2017
31	A Review of Body Dysmorphic Disorder in Aesthetic Surgery Patients and the Legal Implications. ( 28204935 )	Sweis I.E....COHEN M.	2017
32	Recent advances in understanding and managing body dysmorphic disorder. ( 28729345 )	Krebs G....Mataix-Cols D.	2017
33	Body dysmorphic disorder: history and curiosities. ( 28220373 )	FranAsa K....Fioranelli M.	2017
34	An Aberrant Presentation of Delusional Body Dysmorphic Disorder - Importance of Early Psychiatry Liaison. ( 28479822 )	Manohar H....Menon V.	2017
35	Body dysmorphic disorder and its associated psychological and psychopathological features in an Italian community sample. ( 29069974 )	Cerea S....Ghisi M.	2017
36	Reduced cortical thickness in body dysmorphic disorder. ( 27918913 )	Grace S.A....Rossell S.L.	2017
37	Body dysmorphic disorder: Latest neuroanatomical and neuropsychological findings. ( 29072188 )	Tasios K....Michopoulos I.	2017
38	Body dysmorphic disorder: Diagnosis, clinical aspects and treatment strategies. ( 28611331 )	Ahluwalia R....Kaur P.	2017
39	Sex Differences in the Presentation of Body Dysmorphic Disorder in a Community Sample of Adolescents. ( 28541768 )	Schneider S.C....Hudson J.L.	2017
40	Body dysmorphic disorder in the dermatology patient. ( 28511828 )	Koblenzer C.S.	2017
41	Set shifting and visuospatial organization deficits in body dysmorphic disorder. ( 29202381 )	Greenberg J.L....Wilhelm S.	2017
42	Prevalence of Body Dysmorphic Disorder and its Association With Body Features in Female Medical Students. ( 27803720 )	Shaffi Ahamed S....Al Hazmi A.	2016
43	Screening for Body Dysmorphic Disorder in a Dermatology Outpatient Setting at a Tertiary Care Centre. ( 27761090 )	Thanveer F....Khunger N.	2016
44	The Body Dysmorphic Disorder Symptom Scale: Development and preliminary validation of a self-report scale of symptom specific dysfunction. ( 26971118 )	Wilhelm S....Blashill A.J.	2016
45	Modifying interpretation biases in body dysmorphic disorder: Evaluation of a brief computerized treatment. ( 27664367 )	Summers B.J....Cougle J.R.	2016
46	Body dysmorphic disorder symptoms and risk for suicide: The role of depression. ( 27760403 )	Shaw A.M....Timpano K.R.	2016
47	Body Dysmorphic Disorder in Patients Seeking Abdominoplasty, Rhinoplasty, and Rhytidectomy. ( 26818280 )	de Brito M.J....Ferreira L.M.	2016
48	Cognitive-Behavioral Therapy for Body Dysmorphic Disorder by Proxy. ( 27423167 )	Greenberg J.L....Wilhelm S.	2016
49	'I will be at death's door and realize that I've wasted maybe half of my life on one body part': the experience of living with body dysmorphic disorder. ( 27314665 )	Brohede S....Blomberg K.	2016
50	Prevalence of Body Dysmorphic Disorder and Muscle Dysmorphia Among Entry-Level Military Personnel. ( 27136659 )	Campagna J.D....Bowsher B.	2016

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Genes for Body Dysmorphic Disorder

Genes related to Body Dysmorphic Disorder (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SLITRK1	SLIT And NTRK Like Family Member 1	Protein Coding	16.58	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	SLC25A24	Solute Carrier Family 25 Member 24	Protein Coding	16.07	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	TFCP2	Transcription Factor CP2	Protein Coding	15.54	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	KCNJ16	Potassium Voltage-Gated Channel Subfamily J Member 16	Protein Coding	15.3	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	GPC6	Glypican 6	Protein Coding	15.23	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	GALE	UDP-Galactose-4-Epimerase	Protein Coding	15.21	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	VPS13B	Vacuolar Protein Sorting 13 Homolog B	Protein Coding	15.19	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	GPC1	Glypican 1	Protein Coding	15.17	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	GPC3	Glypican 3	Protein Coding	14.92	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Body Dysmorphic Disorder

Copy number variations for Body Dysmorphic Disorder from CNVD:

⁷

#	CNVD ID	Chromosom	Start	End	Type	Gene Symbol	CNVD Disease
1	63474	12	119100000	132349534	Deletion	FBXW8	dysmorphic
2	63477	12	119100000	132349534	Deletion	FZD10	dysmorphic
3	63480	12	119100000	132349534	Deletion	NCOR2	dysmorphic
4	63483	12	119100000	132349534	Deletion	P2RX2	dysmorphic
5	63486	12	119100000	132349534	Deletion	RAN	dysmorphic
6	63489	12	119100000	132349534	Deletion	STX2	dysmorphic
7	63492	12	119100000	132349534	Deletion	TBX3	dysmorphic
8	63495	12	119100000	132349534	Deletion	TESC	dysmorphic
9	63498	12	119100000	132349534	Deletion	ULK1	dysmorphic

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Expression for Body Dysmorphic Disorder

Search GEO for disease gene expression data for Body Dysmorphic Disorder.

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Pathways for Body Dysmorphic Disorder

Pathways related to Body Dysmorphic Disorder according to KEGG:

³⁷

#	Name	Kegg Source Accession
1	Serotonergic synapse	hsa04726

Pathways related to Body Dysmorphic Disorder according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of water-soluble vitamins and cofactors ⁶⁶ Show member pathways [2Fe-2S] iron-sulfur cluster biosynthesis ¹ Biotin transport and metabolism ⁶⁶ biotin-carboxyl carrier protein assembly ¹ coenzyme A biosynthesis ¹ Coenzyme A biosynthesis ⁶⁶ flavin biosynthesis ¹ folate polyglutamylation ¹ Metabolism of folate and pterines ⁶⁶ Metabolism of vitamins and cofactors ⁶⁶ molybdenum cofactor biosynthesis ¹ Molybdenum cofactor biosynthesis ⁶⁶ thiamin salvage III ¹ thio-molybdenum cofactor biosynthesis ¹ Vitamin B1 (thiamin) metabolism ⁶⁶ Vitamin B2 (riboflavin) metabolism ⁶⁶ Vitamin B5 (pantothenate) metabolism ⁶⁶ Vitamin C (ascorbate) metabolism ⁶⁶ Vitamins B6 activation to pyridoxal phosphate ⁶⁶	12.22	GPC1 GPC3 GPC6
2	Glycosaminoglycan metabolism ⁶⁶ Show member pathways chondroitin sulfate biosynthesis ¹ chondroitin sulfate biosynthesis (late stages) ¹ Heparan sulfate/heparin (HS-GAG) metabolism ⁶⁶ HS-GAG biosynthesis ⁶⁶ Hyaluronan biosynthesis and export ⁶⁶ Hyaluronan metabolism ⁶⁶ Hyaluronan uptake and degradation ⁶⁶ Metabolism of carbohydrates ⁶⁶	12.21	GALE GPC1 GPC3 GPC6
3	Chondroitin sulfate/dermatan sulfate metabolism ⁶⁶ Show member pathways A tetrasaccharide linker sequence is required for GAG synthesis ⁶⁶ chondroitin biosynthesis ¹ Chondroitin sulfate biosynthesis ⁶⁶ CS/DS degradation ⁶⁶ Defective B3GALT6 causes EDSP2 and SEMDJL1 ⁶⁶ Defective B3GAT3 causes JDSSDHD ⁶⁶ Defective B4GALT7 causes EDS, progeroid type ⁶⁶ Defective CHST14 causes EDS, musculocontractural type ⁶⁶ Defective CHST3 causes SEDCJD ⁶⁶ Defective CHSY1 causes TPBS ⁶⁶ Defective EXT1 causes exostoses 1, TRPS2 and CHDS ⁶⁶ Defective EXT2 causes exostoses 2 ⁶⁶ dermatan sulfate biosynthesis ¹ Dermatan sulfate biosynthesis ⁶⁶ dermatan sulfate biosynthesis (late stages) ¹ Diseases associated with glycosaminoglycan metabolism ⁶⁶ glycoaminoglycan-protein linkage region biosynthesis ¹ Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate ³⁷ Glypican pathway ¹ HS-GAG degradation ⁶⁶ Proteogylcan syndecan-mediated signaling events ¹	12.09	GPC1 GPC3 GPC6
4	mTOR signaling pathway (KEGG) ⁶⁵ Show member pathways mTOR signaling pathway ³⁷	12.01	GPC1 GPC3 GPC6
5	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁵	11.89	GPC1 GPC3 GPC6
6	Metabolism of fat-soluble vitamins ⁶⁶ Show member pathways Metabolism of vitamin K ⁶⁶ Retinoid metabolism and transport ⁶⁶ The retinoid cycle in cones (daylight vision) ⁶⁶ Visual phototransduction ⁶⁶ Vitamin D (calciferol) metabolism ⁶⁶	11.76	GPC1 GPC3 GPC6
7	Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling ⁶⁵ Show member pathways Basal cell carcinoma ³⁷	11.31	GPC1 GPC3 GPC6
8	Diseases of glycosylation ⁶⁶ Show member pathways Diseases associated with O-glycosylation of proteins ⁶⁶	10.96	GPC1 GPC3 GPC6

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GO Terms for Body Dysmorphic Disorder

Cellular components related to Body Dysmorphic Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	anchored component of membrane	GO:0031225	9.43	GPC1 GPC3 GPC6
2	Golgi lumen	GO:0005796	9.33	GPC1 GPC3 GPC6
3	lysosomal lumen	GO:0043202	9.13	GPC1 GPC3 GPC6
4	anchored component of plasma membrane	GO:0046658	8.8	GPC1 GPC3 GPC6

Biological processes related to Body Dysmorphic Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	retinoid metabolic process	GO:0001523	9.5	GPC1 GPC3 GPC6
2	regulation of signal transduction	GO:0009966	9.43	GPC1 GPC3 GPC6
3	glycosaminoglycan biosynthetic process	GO:0006024	9.33	GPC1 GPC3 GPC6
4	glycosaminoglycan metabolic process	GO:0030203	9.13	GPC1 GPC3 GPC6
5	glycosaminoglycan catabolic process	GO:0006027	8.8	GPC1 GPC3 GPC6

Molecular functions related to Body Dysmorphic Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heparan sulfate proteoglycan binding	GO:0043395	8.8	GPC1 GPC3 GPC6

Sources

Sources for Body Dysmorphic Disorder

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia