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BMIQ11
MCID: BDY004
MIFTS: 76

Body Mass Index Quantitative Trait Locus 11 (BMIQ11)

Categories: Bone diseases, Genetic diseases, Metabolic diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Body Mass Index Quantitative Trait Locus 11

About this section

MalaCards integrated aliases for Body Mass Index Quantitative Trait Locus 11:

Name: Body Mass Index Quantitative Trait Locus 11 56 29 39
Obesity 56 12 73 29 54 6 42 43 15 39 17 71 32
Obesity, Early-Onset, Susceptibility to 56 29 6
Leanness, Inherited 56 29 6
Obesity, Severe, and Type Ii Diabetes 56 6
Obesity, Susceptibility to, Bmiq11 56 13
Obesity, Mild, Early-Onset 56 6
Obesity, Association with 56 6
Obesity, Late-Onset 56 6
Obesity , Susceptibility to 6
Obesity, Susceptibility to 56
Obesity, Early-Onset 56
Obesity, Severe 56
Obesity Bmiq11 56
Bmiq11 56

Characteristics:

HPO:

31
obesity:
Inheritance autosomal dominant inheritance autosomal recessive inheritance polygenic inheritance


Classifications:

MalaCards categories:
Global: Genetic diseases Metabolic diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9970
ICD9CM 34 278.00
MeSH 43 D009765
NCIt 49 C3283
SNOMED-CT 67 414916001
ICD10 32 E66 E66.0 E66.9
SNOMED-CT via HPO 68 258211005 263681008 414915002
UMLS 71 C0028754
Sources

Summaries for Body Mass Index Quantitative Trait Locus 11

About this section
MedlinePlus : 42 Obesity means having too much body fat. It is different from being overweight, which means weighing too much. The weight may come from muscle, bone, fat, and/or body water. Both terms mean that a person's weight is greater than what's considered healthy for his or her height. Obesity happens over time when you eat more calories than you use. The balance between calories-in and calories-out differs for each person. Factors that might affect your weight include your genetic makeup, overeating, eating high-fat foods, and not being physically active. Obesity increases your risk of diabetes, heart disease, stroke, arthritis, and some cancers. If you have obesity, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases. For example, that means losing 10 to 20 pounds if you weigh 200 pounds. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and diabetes mellitus, noninsulin-dependent, and has symptoms including symptoms, high weight and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Glucose / Energy Metabolism and cAMP signaling pathway. The drugs Citalopram and Oseltamivir have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and breast, and related phenotypes are obesity and decreased resting energy expenditure

Disease Ontology : 12 An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has material basis in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.

UniProtKB/Swiss-Prot : 73 Obesity: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

More information from OMIM: 300306 601665
Sources

Related Diseases for Body Mass Index Quantitative Trait Locus 11

About this section

Diseases in the Body Mass Index Quantitative Trait Locus 11 family:

Body Mass Index Quantitative Trait Locus 9 Body Mass Index Quantitative Trait Locus 8
Body Mass Index Quantitative Trait Locus 1 Body Mass Index Quantitative Trait Locus 2
Body Mass Index Quantitative Trait Locus 3 Body Mass Index Quantitative Trait Locus 4
Body Mass Index Quantitative Trait Locus 10 Body Mass Index Quantitative Trait Locus 7
Body Mass Index Quantitative Trait Locus 5 Body Mass Index Quantitative Trait Locus 6
Body Mass Index Quantitative Trait Locus 12 Body Mass Index Quantitative Trait Locus 13
Body Mass Index Quantitative Trait Locus 14 Body Mass Index Quantitative Trait Locus 15
Body Mass Index Quantitative Trait Locus 18 Body Mass Index Quantitative Trait Locus 19
Body Mass Index Quantitative Trait Locus 20

Diseases related to Body Mass Index Quantitative Trait Locus 11 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2065)
# Related Disease Score Top Affiliating Genes
1 leptin deficiency or dysfunction 36.0 PPARG POMC MC4R GHRL AGRP ADRB3
2 diabetes mellitus, noninsulin-dependent 35.4 UCP3 PRMT7 PPARG POMC NR0B2 MC4R
3 abdominal obesity-metabolic syndrome 1 35.3 PPARG GHRL ADRB3
4 glucose intolerance 34.3 PPARG POMC GHRL ENPP1 ADRB3
5 eating disorder 34.1 POMC MC4R GHRL AGRP
6 prader-willi syndrome 34.0 POMC MC4R GHRL AGRP
7 sleep apnea 33.9 PPARG GHRL ADRB2
8 diabetes mellitus 33.7 UCP3 PPARG POMC MC4R GHRL ENPP1
9 migraine with or without aura 1 33.6 POMC POLG BRCA2 ADRB2
10 gestational diabetes 33.3 PPARG ENPP1 ADRB3
11 hypertension, essential 33.2 PPARG POMC MIR143 MC4R GNAS GHRL
12 overnutrition 33.1 UCP3 PPARG POMC MC4R GHRL AGRP
13 pseudohypoparathyroidism, type ic 33.1 MC4R GNAS
14 anorexia nervosa 32.6 POMC MC4R GHRL AGRP
15 hyperandrogenism 32.5 PPARG POMC MC4R
16 bulimia nervosa 32.2 POMC MC4R GHRL
17 pain agnosia 32.1 POMC ADRB3 ADRB2
18 cardiovascular system disease 32.0 PPARG MIR143 GHRL ADRB2
19 ovarian disease 32.0 PPARG POMC MIR143 BRCA2
20 hyperthyroidism 31.7 POMC GNAS GHRL
21 prostatic adenoma 31.6 ADRB3 ADRB2
22 hypokalemia 31.6 POMC KCNH2 ADRB2
23 familial hyperlipidemia 31.6 PRMT7 PPARG ADRB3
24 thyroid gland disease 31.5 PPARG POMC GNAS
25 breast disease 31.4 PPARG POMC MIR143 BRCA2
26 acromegaly 31.2 POMC GNAS GHRL
27 phenylketonuria 31.0 PPARG POLG GHRL
28 osseous heteroplasia, progressive 30.9 POMC GNAS ENPP1 BRCA2
29 dowling-degos disease 1 30.8 POMC GNAS
30 multiple endocrine neoplasia, type i 30.5 POMC GNAS GHRL
31 obesity, early-onset, with adrenal insufficiency and red hair 12.7
32 morbid obesity and spermatogenic failure 12.7
33 obesity-hypoventilation syndrome 12.6
34 genetic obesity 12.6
35 abdominal obesity-metabolic syndrome quantitative trait locus 2 12.6
36 mental retardation, truncal obesity, retinal dystrophy, and micropenis syndrome 12.5
37 obesity, hyperphagia, and developmental delay 12.5
38 spastic paraplegia, intellectual disability, nystagmus, and obesity 12.5
39 retinal dystrophy and obesity 12.5
40 wilms tumor, aniridia, genitourinary anomalies, mental retardation, and obesity syndrome 12.5
41 abdominal obesity-metabolic syndrome 3 12.5
42 hypothalamic obesity 12.5
43 hydrocephalus obesity hypogonadism 12.5
44 x-linked intellectual disability - short stature - obesity 12.4
45 abdominal obesity-metabolic syndrome 4 12.4
46 body mass index quantitative trait locus 19 12.4
47 leptin receptor deficiency 12.4
48 body mass index quantitative trait locus 20 12.3
49 aniridia - ptosis - intellectual disability - familial obesity 12.3
50 obesity due to melanocortin 4 receptor deficiency 12.3

Graphical network of the top 20 diseases related to Body Mass Index Quantitative Trait Locus 11:



Diseases related to Body Mass Index Quantitative Trait Locus 11
Sources

Symptoms & Phenotypes for Body Mass Index Quantitative Trait Locus 11

About this section

Human phenotypes related to Body Mass Index Quantitative Trait Locus 11:

31
# Description HPO Frequency HPO Source Accession
1 obesity 31 HP:0001513
2 decreased resting energy expenditure 31 HP:0012340
3 increased waist to hip ratio 31 HP:0031819

Clinical features from OMIM:

300306 601665

UMLS symptoms related to Body Mass Index Quantitative Trait Locus 11:


symptoms, high weight, obesity, metabolically benign, monogenic obesity

MGI Mouse Phenotypes related to Body Mass Index Quantitative Trait Locus 11:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.39 ADRB2 ADRB3 AGRP BBIP1 BRCA2 CARTPT
2 adipose tissue MP:0005375 10.36 ADRB2 ADRB3 AGRP CARTPT ENPP1 GHRL
3 homeostasis/metabolism MP:0005376 10.36 ADRB2 ADRB3 AGRP BRCA2 CARTPT ENPP1
4 behavior/neurological MP:0005386 10.31 ADRB2 ADRB3 AGRP BBIP1 BRCA2 CARTPT
5 endocrine/exocrine gland MP:0005379 10.2 ADRB2 ADRB3 BRCA2 CARTPT GHRL GNAS
6 cardiovascular system MP:0005385 10.18 ADRB2 ENPP1 GLDC GNAS KCNH2 MC4R
7 liver/biliary system MP:0005370 9.97 AGRP ENPP1 GNAS MC4R NR0B2 POMC
8 nervous system MP:0003631 9.93 ADRB2 AGRP BBIP1 BRCA2 ENPP1 GLDC
9 muscle MP:0005369 9.87 ADRB2 ENPP1 GNAS KCNH2 POLG PPARG
10 neoplasm MP:0002006 9.8 BRCA2 GNAS MC4R POLG POMC PPARG
11 no phenotypic analysis MP:0003012 9.5 ADRB2 AGRP GNAS MC4R POLG POMC
12 skeleton MP:0005390 9.32 ADRB2 BRCA2 CARTPT ENPP1 GLDC GNAS
Sources

Drugs & Therapeutics for Body Mass Index Quantitative Trait Locus 11

About this section

Drugs for Body Mass Index Quantitative Trait Locus 11 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1120)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4 59729-33-8 2771
2
Oseltamivir Approved Phase 4 204255-11-8, 196618-13-0 65028
3
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
4
Enalaprilat Approved Phase 4 76420-72-9 6917719
5
Lactitol Approved, Investigational Phase 4 585-88-6, 585-86-4 493591
6
Clonidine Approved Phase 4 4205-90-7 2803
7
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
8
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
9
Metyrapone Approved, Investigational Phase 4 54-36-4 4174
10
Norfloxacin Approved Phase 4 70458-96-7 4539
11
Ticagrelor Approved Phase 4 274693-27-5 9871419
12
Suvorexant Approved, Investigational Phase 4 1030377-33-3
13
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
14
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
15
Dapsone Approved, Investigational Phase 4 80-08-0 2955
16
Caspofungin Approved Phase 4 162808-62-0, 179463-17-3 2826718 468682
17
Acetaminophen Approved Phase 4 103-90-2 1983
18
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
19
Meropenem Approved, Investigational Phase 4 96036-03-2, 119478-56-7 441130 64778
20
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
21
Adenosine Approved, Investigational Phase 4 58-61-7 60961
22
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
23
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
24
Saxagliptin Approved Phase 4 361442-04-8 11243969
25
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
26
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
27
Zonisamide Approved, Investigational Phase 4 68291-97-4 5734
28
Norepinephrine Approved Phase 4 51-41-2 439260
29
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
30
Enoxaparin Approved Phase 4 9005-49-6 772
31
Pitavastatin Approved Phase 4 147526-32-7, 147511-69-1 6366718 5282452
32
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
33
Ibuprofen Approved Phase 4 15687-27-1 3672
34
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
35
Sodium citrate Approved, Investigational Phase 4 68-04-2
36
Histamine Approved, Investigational Phase 4 51-45-6 774
37
Infliximab Approved Phase 4 170277-31-3
38
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
39
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
40
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
41
Nadroparin Approved, Investigational Phase 4
42
Memantine Approved, Investigational Phase 4 19982-08-2 4054
43
Tigecycline Approved Phase 4 220620-09-7 5282044
44
Lactulose Approved Phase 4 4618-18-2 11333
45
Cefuroxime Approved Phase 4 55268-75-2 5479529 5361202
46
Ethambutol Approved Phase 4 74-55-5 3279 14052
47
Ziprasidone Approved Phase 4 146939-27-7 60854
48
Atenolol Approved Phase 4 29122-68-7 2249
49
Bilberry Approved, Experimental Phase 4
50
Ferrous fumarate Approved Phase 4 141-01-5

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 Double Blinded Randomised Trial Comparing Metformin Versus Placebo in NASH Patients Receiving Bariatric Surgery for Obesity Unknown status NCT00134303 Phase 4 Metformin
2 Effect of Bile Acids and Bile Acid Sequstrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass Unknown status NCT02952963 Phase 4 Chenodeoxycholic Acid;Colesevelam
3 The Effect of Obesity in Dexmedetomidine Metabolic Clearance Unknown status NCT02557867 Phase 4 Dexmedetomidine
4 The Effect of Moxonidine and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension: a Randomised, Double Blind, Active Comparator Clinical Trial Unknown status NCT01360710 Phase 4 Moxonidine;Irbesartan
5 Effect of Acarbose and Vildagliptin on Visceral Fat Distribution in Overweight and Obesity Patients With Newly Diagnosed Type 2 Diabetes Mellitus: A Randomized Control Study Unknown status NCT02999841 Phase 4 Acarbose;Vildagliptin
6 Assessment of the Effect of Moxonidine and Diet on Cardiac, Renal and Endothelial Function in Young Subjects With Abdominal Obesity Unknown status NCT01180231 Phase 4 Moxonidine (Physiotens)
7 The Effect of Vitamin A Supplementation on CD4+ T-cell Secretion in Obese Individuals Unknown status NCT01405352 Phase 4
8 Effects of Chenodeoxycholic Acid and Colesevelam on GLP-1 Secretion, During a Meal, After Roux-en-Y Gastric Bypass Unknown status NCT02876484 Phase 4 Colesevelam;Chenodeoxycholic Acid
9 A Study of the Pharmacokinetics of Dexmedetomidine in Morbid Obesity. Unknown status NCT01864187 Phase 4 Dexmedetomidine
10 Effect of Saxagliptin on Body Fat , Glucose and Beta Cell Function in Patients With Newly Diagnosed Pre-Diabetes Mellitus and Obesity Unknown status NCT01960205 Phase 4 Saxagliptin;saxagliptin;metformin
11 Evaluation of the Effects of Laying Early (Between 12 and 16) a Gastric Band on the Prevention of Morbid Obesity in Late Adolescence. Randomized Checked Against Standard Management of Obesity in This Population. Unknown status NCT01700738 Phase 4
12 Levonorgestrel-releasing Intrauterine Device Effects on Hemostatic and Arterial Function of Obese Women Unknown status NCT01320917 Phase 4
13 Prevention and Control of Obesity in Primary School Children in Tehran Unknown status NCT02082080 Phase 4
14 Healthy Opportunities for Physical Activity and Nutrition (HOP'N) After-School Project Unknown status NCT01015599 Phase 4
15 Evaluation of Family Intervention Program for the Treatment of Overweight or Obese Children (Nereu Program): Randomized Clinical Trial Unknown status NCT01878994 Phase 4
16 Laparoscopic Roux-en-Y Gastric Bypass vs. Laparoscopic BPD-Duodenal Switch for Superobesity (BMI > 50 kg/m2)- A Randomized Clinical Trial Unknown status NCT00327912 Phase 4
17 Prospective, Pharmacokinetic Study for Determination of the Relationship Between Lean Body Weight and Anti-Xa Activity 4 Hours After Subcutaneous Injection of 5700 IU Nadroparin in Morbidly Obese Patients After Bariatric Surgery. Unknown status NCT02295150 Phase 4 Nadroparin
18 Beijing Chao-yang Hospital, Capital Medical University Unknown status NCT02583438 Phase 4 Saxagliptin (Bristol-Myers Squibb Company)
19 Randomisation to Endoluminal Intestinal Liner Alone Versus With Incretin Analogue in SustainEd Diabesity (REVISE-Diabesity) Unknown status NCT02055014 Phase 4 Liraglutide
20 Laparoscopic Bariatric Surgery: Impact of the Level of Neuromuscular Blockade on Surgical Conditions - Comparison Between Moderate and Deep Neuromuscular Blockade Unknown status NCT02118844 Phase 4 rocuronium
21 Correlation of Postoperative VAS Values and Body Mass Index in Patients Undergoing Abdominal Surgery: A Clinical Trial Unknown status NCT02017314 Phase 4 Morphine
22 Laparoscopic Non Banded Vertical (Magenstrasse and Mill) Gastroplasty In Bariatric Surgery. Morbidity and Results on Weight Loss and Associated Co-morbidities Unknown status NCT02050477 Phase 4
23 Double-blind Randomized Trial Using Oral Metformin Versus Placebo in the Treatment of Acanthosis Nigricans in Children With Obesity Unknown status NCT02438020 Phase 4 Metformin
24 The Therapeutic Effect of Catgut Embedding in Obesity-A Randomized, Double-blind, Placebo-controlled Clinical Trial Unknown status NCT02276235 Phase 4
25 Prospective, Randomized, Double - Blind, Placebo Controlled Trial of Dietary Modification in Conjunction With Probiotic Therapy on Clinical and Endocrinological Parameters as Well as Body Composition in Women With Polycystic Ovary Syndrome Unknown status NCT03325023 Phase 4
26 Comparing the Efficacy of Two Frequently Used Doses of Enoxaparin for VTE Prophylaxis After Bariatric Surgery Unknown status NCT01970202 Phase 4 40mg Enoxaparin;60mg Enoxaparin
27 International, Multi Centre, Open, Prospective, Randomized Study: Banded Versus Conventional Laparoscopic Roux-en-Y (GABY) Unknown status NCT01015469 Phase 4
28 Influence of Erythromycin on ad Libitum Food Intake and the Evaluation of Motilin in Food Timing in Healthy Volunteers and Patients Unknown status NCT03024879 Phase 4 Erythromycin;Saline
29 What is the Effects of Incretin on the Blood Pressure and Lipid in Overweight or Obese Diabetes Patients With Masked Hypertension: Liraglutide Plus Mitiglinide Comparing Metformin Plus Mitiglinide or Mitiglinide Alone（BLOOD STUDY） Unknown status NCT02503943 Phase 4 "Liraglutide" and "Mitiglinide";"Metformin" and "Mitiglinide";"Mitiglinide"
30 Weight Reduction Alone May Not be Sufficient to Maintain Disease Remission in Obese Patients With Psoriasis: a Randomized, Investigator-blinded Study Unknown status NCT01439425 Phase 4
31 Prospective Randomized Study of Effects of Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy Unknown status NCT00667706 Phase 4
32 Gut Hormones as Mediators of Different Weight Loss Responses After Roux-en-Y Gastric Bypass Unknown status NCT02374632 Phase 4
33 The Effect of Exenatide on Brown Adipose Tissue Activity and Energy Expenditure in Healthy Young Men Unknown status NCT03002675 Phase 4 Bydureon
34 What is the Effects of Prokinetic Drug on the Blood Glucose in Type 2 Diabetes Patients: Mosapride Comparing Placebo Unknown status NCT02606617 Phase 4 Mosapride;Placebo
35 Prospective Randomized Trials of Gastric Bypass Surgery in Patients With Type II Diabetes Mellitus Unknown status NCT00540462 Phase 4
36 The Effect of Mirabegron on Brown Adipose Tissue in Healthy Young White Caucasian and South Asian Men Unknown status NCT03012113 Phase 4 Mirabegron;Placebo Oral Capsule
37 The Need of Dosing Adjustment for Simvastatin in Obese Patients Post Bariatric Surgery- Laparoscopic Sleeve Gastrectomy (LSG) Unknown status NCT03571802 Phase 4 Simvastatin
38 Sildenafil Activates Browning of White Adipose and Improves Insulin Sensitivity in Human Adults Unknown status NCT02524184 Phase 4 sildenafil;placebo
39 The Research About the Influence of Medical Interventions in the Period of Insulin Resistance on Prevalence of Abnormal Glucose Tolerance Unknown status NCT02502344 Phase 4 Metformin
40 Study of the Concentrations of Long Acting Morphine After Oral Absorption in Subjects Who Underwent Gastric Bypass (OBEMO 2) Unknown status NCT02641301 Phase 4 Sustained release morphine sulfate, 30 mg
41 Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome Unknown status NCT01366391 Phase 4 Metformin
42 Changes in Central Aortic Pressure, Endothelial Function and Biomarkers in African Americans With Cardiometabolic Syndrome: Comparison of Amlodipine/Olmesartan Versus Hydrochlorothiazide/Losartan Unknown status NCT01271374 Phase 4 amlodipine and olmesartan;losartan and HCTZ
43 Determining the Minimal Effective Volume (MEAV95) for Interscalene Brachial Plexus Block for Surgical Anesthesia Unknown status NCT01703130 Phase 4
44 Influence of the Aromatase Inhibitor Letrozole on Heart and Liver Function in Obese Men Unknown status NCT02097680 Phase 4 Letrozole;Placebo
45 Effect of aSpirin Versus CilOstazol for Inhibition of Antiplatelet aggRegaTion in Type 2 DM Patients Unknown status NCT02933788 Phase 4 Cilostazol;Acetylsalicylic acid
46 A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE SUPPLEMENTATION WITH KIOLIC® IN PATIENTS WITH DIAGNOSIS OF METABOLIC SYNDROME TO IMPROVE ENDOTHELIAL FUNCTION AND INFLAMMATORY STATE. "KYMES" Unknown status NCT01168700 Phase 4 aged garlic extract;Placebo
47 The ACT-OUT Trial: ACTivity OUTcomes Based on the Consumption of a High Carbohydrate or High Fat Diet in Patients With Metabolic Syndrome Unknown status NCT01357382 Phase 4
48 Study of Metabolic Effects of EndoBarrier Versus Intragastric Balloon in Obese Patients With Type 2 Diabetes. Unknown status NCT01848795 Phase 4
49 Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic Syndrome Unknown status NCT01237769 Phase 4 Vitamin D3
50 The Effects of Cortisol Blockade on Nutritional Sympathetic Nervous System Responsiveness in Overweight and Obese Subjects With Metabolic Syndrome Unknown status NCT01620684 Phase 4 metyrapone;placebo

Search NIH Clinical Center for Body Mass Index Quantitative Trait Locus 11

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Benzphetamine
Benzphetamine hydrochloride
Dexfenfluramine
Dexfenfluramine Hydrochloride
Diethylpropion
Diethylpropion Hydrochloride
Fenfluramine
Fenfluramine Hydrochloride
lorcaserin
lorcaserin hydrochloride
Mazindol
Methamphetamine
orlistat
phendimetrazine
PHENDIMETRAZINE HYDROCHLORIDE
phendimetrazine tartrate
Phenmetrazine
Phenmetrazine Hydrochloride
Phentermine
Phentermine Hydrochloride
PHENTERMINE RESIN
Phenylpropanolamine
Phenylpropanolamine Hydrochloride
sibutramine
SIBUTRAMINE HYDROCHLORIDE

Cochrane evidence based reviews: obesity

Sources

Genetic Tests for Body Mass Index Quantitative Trait Locus 11

About this section

Genetic tests related to Body Mass Index Quantitative Trait Locus 11:

# Genetic test Affiliating Genes
1 Obesity 29 ADRB2 ADRB3 AGRP CARTPT ENPP1 GHRL NR0B2 POMC PPARG SDC3 UCP3
2 Body Mass Index Quantitative Trait Locus 11 29
3 Leanness, Inherited 29
4 Obesity, Early-Onset, Susceptibility to 29
Sources

Anatomical Context for Body Mass Index Quantitative Trait Locus 11

About this section

MalaCards organs/tissues related to Body Mass Index Quantitative Trait Locus 11:

40
Liver, Heart, Breast, Brain, Testes, Kidney, Bone
Sources

Publications for Body Mass Index Quantitative Trait Locus 11

About this section

Articles related to Body Mass Index Quantitative Trait Locus 11:

(show top 50) (show all 33413)
# Title Authors PMID Year
1
A PYY Q62P variant linked to human obesity. 6 61 54
16368708 2006
2
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. 6 61
26287746 2015
3
Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor. 6 54
18801902 2009
4
Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees. 6 54
18559663 2008
5
Variation in FTO contributes to childhood obesity and severe adult obesity. 61 6
17496892 2007
6
ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children. 54 6
16968801 2006
7
Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating. 54 6
16507637 2006
8
Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish. 54 6
16204371 2005
9
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. 54 6
16025115 2005
10
Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans. 54 6
15054840 2004
11
The SLC6A14 gene shows evidence of association with obesity. 61 56
14660752 2003
12
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. 54 6
12646665 2003
13
A polymorphism in the human agouti-related protein is associated with late-onset obesity. 54 6
12213871 2002
14
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. 54 6
12165561 2002
15
Mutations in the preproghrelin/ghrelin gene associated with obesity in humans. 6 54
11502844 2001
16
Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. 6 54
11136233 2001
17
Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young Danish subjects. 54 6
10999801 2000
18
Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene. 54 6
10577903 1999
19
Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. 54 6
9769326 1998
20
The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort. 6 54
9709965 1998
21
A mutation of the beta 3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride. 6 54
9112025 1997
22
Lack of association between the Trp64 Arg mutation in the beta 3-adrenergic receptor gene and obesity in Japanese men: a longitudinal analysis. 6 54
9100608 1997
23
A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. 6 54
9054940 1997
24
Role of the beta 3-adrenergic receptor locus in obesity and noninsulin-dependent diabetes among members of Caucasian families with a diabetic sibling pair. 6 54
8954053 1996
25
The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts. 6 54
8903328 1996
26
Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. 54 6
7609750 1995
27
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. 6
19151714 2009
28
A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities. 6
17351148 2007
29
Medical sequencing at the extremes of human body mass. 6
17357083 2007
30
Positive association of obesity with single nucleotide polymorphisms of syndecan 3 in the Korean population. 6
17018662 2006
31
A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine. 6
16609882 2006
32
No evidence for association of the ENPP1 (PC-1) K121Q variant with risk of type 2 diabetes in a Japanese population. 6
16607460 2006
33
Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance. 6
15677494 2005
34
CART peptide levels are altered by a mutation associated with obesity at codon 34. 6
15326462 2004
35
Effects of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene on insulin sensitivity in small for gestational age neonates. 6
15472194 2004
36
Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians. 56
15331564 2004
37
The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth. 6
15126519 2004
38
The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes. 6
15001634 2004
39
A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. 6
14988267 2004
40
Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance. 6
14671192 2003
41
Association of the mitochondrial DNA 15497G/A polymorphism with obesity in a middle-aged and elderly Japanese population. 6
12905068 2003
42
Ghrelin gene: identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students. 6
12050239 2002
43
Structure and receptor binding of PYY analogs. 6
11825645 2002
44
Nucleotide pyrophosphatase gene polymorphism associated with ossification of the posterior longitudinal ligament of the spine. 6
11771660 2002
45
The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance. 6
11739459 2001
46
The gene structure and minimal promoter of the human agouti related protein. 6
11602360 2001
47
Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. 6
11522684 2001
48
Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor. 6
11095426 2000
49
Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24. 56
10999806 2000
50
Primary structures of PYY, [Pro(34)]PYY, and PYY-(3-36) confer different conformations and receptor selectivity. 6
10898754 2000