MCID: BLV001
MIFTS: 31

Bolivian Hemorrhagic Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Bolivian Hemorrhagic Fever

MalaCards integrated aliases for Bolivian Hemorrhagic Fever:

Name: Bolivian Hemorrhagic Fever 12 74 58 15
Hemorrhagic Fever, Bolivian 71
Machupo Hemorrhagic Fever 58

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050195
ICD10 32 A96.1
ICD10 via Orphanet 33 A96.1
UMLS via Orphanet 72 C0282192
Orphanet 58 ORPHA319229
UMLS 71 C0282192

Summaries for Bolivian Hemorrhagic Fever

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Machupo virus, which is transmitted by vesper mouse, Calomys callosus. The infection has symptom fever, has symptom headache, has symptom fatigue, has symptom myalgia, has symptom arthralgia, has symptom bleeding from the oral and nasal mucosa, and has symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts.

MalaCards based summary : Bolivian Hemorrhagic Fever, also known as hemorrhagic fever, bolivian, is related to argentine hemorrhagic fever and marburg hemorrhagic fever, and has symptoms including fatigue, fever and arthralgia. An important gene associated with Bolivian Hemorrhagic Fever is GTPBP1 (GTP Binding Protein 1), and among its related pathways/superpathways are Interferon gamma signaling and NF-kappaB Signaling. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Bolivian hemorrhagic fever (BHF), also known as black typhus or Ordog Fever, is a hemorrhagic fever and... more...

Related Diseases for Bolivian Hemorrhagic Fever

Diseases related to Bolivian Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 argentine hemorrhagic fever 29.8 TSG101 TFRC MBTPS1 IRF3 GTPBP1 GP2
2 marburg hemorrhagic fever 10.2 GTPBP1 GP2
3 exanthem 10.2
4 tremor 10.2
5 ebola hemorrhagic fever 10.2 GTPBP1 GP2
6 ocular motor apraxia 10.1
7 meningoencephalitis 10.1
8 disseminated intravascular coagulation 10.1
9 neutropenia 10.1
10 bronchopneumonia 10.1
11 thrombocytopenia 10.1
12 hemorrhagic disease 10.1
13 central nervous system disease 10.1
14 lymphopenia 10.1
15 nervous system disease 10.1
16 splenomegaly 10.1
17 viral hemorrhagic fever 10.1
18 swine influenza 10.1 GP2 DDX58
19 venezuelan hemorrhagic fever 10.0 MBTPS1 GTPBP1 GP2
20 crimean-congo hemorrhagic fever 10.0 MBTPS1 DDX58
21 hepatitis e 9.7 TSG101 DDX58
22 newcastle disease 9.6 IRF3 DDX58
23 west nile virus 9.5 IRF3 DDX58
24 lymphocytic choriomeningitis 9.5 IRF3 DDX58 DAG1
25 chikungunya 9.4 STAT1 DDX58
26 brazilian hemorrhagic fever 9.4 TFRC MBTPS1 GTPBP1 GP2 DAG1
27 aicardi-goutieres syndrome 9.4 IRF3 DHX58 DDX58
28 severe acute respiratory syndrome 9.3 STAT1 IRF3 DDX58
29 mouth disease 9.2 STAT1 IRF3 DDX58
30 viral infectious disease 9.2 STAT1 IRF3 DDX58
31 influenza 9.2 STAT1 IRF3 DDX58
32 herpes simplex 9.2 STAT1 IRF3 DDX58
33 hepatitis c 9.1 STAT1 IRF3 DDX58
34 noonan syndrome 1 9.0 STAT1 IRF3 GP2 DDX58
35 human immunodeficiency virus type 1 8.9 TSG101 TFRC STAT1 IRF3
36 microphthalmia with limb anomalies 8.9 STAT1 IRF3 DHX58 DDX58
37 rabies 8.9 STAT1 IRF3 DHX58 DDX58
38 measles 8.9 STAT1 IRF3 DHX58 DDX58
39 lassa fever 8.4 TSG101 MBTPS1 IRF3 GTPBP1 GP2 DDX58

Graphical network of the top 20 diseases related to Bolivian Hemorrhagic Fever:



Diseases related to Bolivian Hemorrhagic Fever

Symptoms & Phenotypes for Bolivian Hemorrhagic Fever

Symptoms:

12
  • fatigue
  • fever
  • arthralgia
  • myalgia
  • headache
  • bleeding from the
  • bleeding from the bronchopulmonary

GenomeRNAi Phenotypes related to Bolivian Hemorrhagic Fever according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.74 DAG1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.74 TSG101
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.74 TSG101
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.74 DAG1 GTPBP1 TSG101
5 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.74 DAG1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.74 DAG1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.74 TSG101
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.74 GTPBP1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.74 GTPBP1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.74 TSG101
11 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.74 DAG1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.74 GTPBP1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.74 DAG1 TSG101
14 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.74 DAG1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.74 TSG101
16 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.74 GTPBP1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.74 TSG101
18 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.74 GTPBP1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.74 DAG1 GTPBP1 TSG101
20 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.74 GTPBP1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-97 9.74 GTPBP1

MGI Mouse Phenotypes related to Bolivian Hemorrhagic Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 DAG1 DDX58 DHX58 IRF3 MBTPS1 STAT1
2 homeostasis/metabolism MP:0005376 9.56 DAG1 DDX58 DHX58 IRF3 MBTPS1 STAT1
3 normal MP:0002873 9.1 DAG1 GP2 GTPBP1 STAT1 TFRC TSG101

Drugs & Therapeutics for Bolivian Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Bolivian Hemorrhagic Fever

Genetic Tests for Bolivian Hemorrhagic Fever

Anatomical Context for Bolivian Hemorrhagic Fever

Publications for Bolivian Hemorrhagic Fever

Articles related to Bolivian Hemorrhagic Fever:

(show top 50) (show all 51)
# Title Authors PMID Year
1
Monoclonal antibodies with neutralizing activity and Fc-effector functions against the Machupo virus glycoprotein. 61
31801871 2019
2
Description and characterization of a novel live-attenuated tri-segmented Machupo virus in Guinea pigs. 61
29879985 2018
3
An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infection. 61
28680057 2017
4
The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor. 61
27580122 2016
5
Machupo Virus Expressing GPC of the Candid#1 Vaccine Strain of Junin Virus Is Highly Attenuated and Immunogenic. 61
26581982 2016
6
Pathogenesis of Bolivian Hemorrhagic Fever in Guinea Pigs. 61
26139838 2016
7
Research efforts to control highly pathogenic arenaviruses: a summary of the progress and gaps. 61
25549822 2015
8
Pathology of experimental Machupo virus infection, Chicava strain, in cynomolgus macaques (Macaca fascicularis) by intramuscular and aerosol exposure. 61
24990481 2015
9
A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of Machupo virus. 61
25031335 2014
10
Epidemiology and pathogenesis of Bolivian hemorrhagic fever. 61
24636947 2014
11
Rescue of a recombinant Machupo virus from cloned cDNAs and in vivo characterization in interferon (αβ/γ) receptor double knockout mice. 61
24284323 2014
12
[Bolivian hemorrhagic fever]. 61
24000605 2013
13
A STAT-1 knockout mouse model for Machupo virus pathogenesis. 61
21672221 2011
14
Conserved residues in Lassa fever virus Z protein modulate viral infectivity at the level of the ribonucleoprotein. 61
21228230 2011
15
[Chemotherapy for Bolivian hemorrhagic fever in experimentally infected guinea pigs]. 61
20030281 2009
16
Reemergence of Bolivian hemorrhagic fever, 2007-2008. 61
19788833 2009
17
[Use of guinea pigs to evaluate the efficacy of a heterological immunoglobulin against Bolivian hemorrhagic fever]. 61
19708556 2009
18
Genetic diversity among Bolivian arenaviruses. 61
19041349 2009
19
Models for an arenavirus infection in a rodent population: consequences of horizontal, vertical and sexual transmission. 61
19278272 2008
20
Natural nidality in Bolivian hemorrhagic fever and the systematics of the reservoir species. 61
12798015 2002
21
Risks and prevention of nosocomial transmission of rare zoonotic diseases. 61
11170953 2001
22
Treatment of Bolivian hemorrhagic fever with intravenous ribavirin. 61
9145749 1997
23
[Viral hemorrhagic fevers: what is the risk for travelers?]. 61
9612763 1997
24
[The study of protective properties of attenuated strain of Argentinian hemorrhagic fever]. 61
8999669 1996
25
[Experimental study of the possibility of emergency prophylaxis of Bolivian hemorrhagic fever]. 61
8659175 1995
26
Prospects for the control of Bolivian hemorrhagic fever. 61
8903174 1995
27
Bolivian hemorrhagic fever reappears. 61
7640699 1995
28
From the Centers for Disease Control and Prevention. Bolivian hemorrhagic fever--El Beni Department, Bolivia, 1994. 61
7807656 1995
29
Re-emergence of Bolivian hemorrhagic fever. 61
7703000 1994
30
Bolivian hemorrhagic fever--El Beni Department, Bolivia, 1994. 61
7990799 1994
31
Molecular approaches for the treatment of hemorrhagic fever virus infections. 61
8250543 1993
32
[Present status of zoonotic hemorrhagic fevers of South America]. 61
7819800 1993
33
The primary structure of the lymphocytic choriomeningitis virus L gene encodes a putative RNA polymerase. 61
2705303 1989
34
Indirect immunofluorescence, serum neutralization, and viremia responses of rhesus monkeys (Macaca mulatta) to Machupo virus. 61
3014062 1986
35
[Bolivian hemorrhagic fever: epidemiology, symptomatology, management and prognosis]. 61
6248659 1980
36
Studies of the coagulation system and blood pressure during experimental Bolivian hemorrhagic fever in rhesus monkeys. 61
103447 1978
37
Pathology of Bolivian Hemorrhagic fever in the African green monkey. 61
99059 1978
38
The African green monkey as an alternate primate host for studying Machupo virus infection. 61
402863 1977
39
Pathology of chronic Bolivian hemorrhagic fever in the rhesus monkey. 61
181994 1976
40
A rhesus monkey model for the study of Bolivian hemorrhagic fever. 61
173762 1976
41
Comparative histopathology of two strains of Bolivian hemorrhagic fever virus infections in suckling hamsters. 61
4745242 1973
42
Pathology of Bolivian hemorrhagic fever in the rhesus monkey. 61
4202335 1973
43
The measurement of specific antibodies in Bolivian hemorrhagic fever by neutralization of virus plaques. 61
4975291 1969
44
Multiplication of Machupo virus, the etiological agent of Bolivian hemorrhagic fever, in cell cultures. 61
5765269 1969
45
Acidophilic bodies. Their chemical and physical nature in patients with Bolivian hemorrhagic fever. 61
4169327 1968
46
On the mode of transmission of Bolivian hemorrhagic fever. 61
5301560 1967
47
Some characteristics of Machupo virus, causative agent of Bolivian hemorrhagic fever. 61
4378149 1967
48
Bolivian hemorrhagic fever. A pathologic description. 61
6023050 1967
49
Bolivian hemorrhagic fever. 61
6071501 1967
50
Bolivian hemorrhagic fever. A report of four cases. 61
4159195 1966

Variations for Bolivian Hemorrhagic Fever

Expression for Bolivian Hemorrhagic Fever

Search GEO for disease gene expression data for Bolivian Hemorrhagic Fever.

Pathways for Bolivian Hemorrhagic Fever

Pathways related to Bolivian Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.82 STAT1 IRF3 DDX58
2 11.77 STAT1 IRF3 DHX58 DDX58
3
Show member pathways
10.16 STAT1 IRF3 DDX58

GO Terms for Bolivian Hemorrhagic Fever

Biological processes related to Bolivian Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.56 STAT1 IRF3 DHX58 DDX58
2 response to peptide hormone GO:0043434 9.48 STAT1 DAG1
3 positive regulation of type I interferon production GO:0032481 9.46 IRF3 DHX58
4 response to exogenous dsRNA GO:0043330 9.43 IRF3 DDX58
5 positive regulation of defense response to virus by host GO:0002230 9.4 STAT1 DDX58
6 positive regulation of interferon-beta production GO:0032728 9.37 IRF3 DDX58
7 negative regulation of type I interferon production GO:0032480 9.33 IRF3 DHX58 DDX58
8 cellular response to exogenous dsRNA GO:0071360 9.32 IRF3 DDX58
9 viral process GO:0016032 9.17 TSG101 TFRC STAT1 IRF3 DHX58 DDX58
10 positive regulation of interferon-alpha production GO:0032727 9.13 STAT1 IRF3 DDX58

Molecular functions related to Bolivian Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.46 TSG101 TFRC STAT1 IRF3
2 single-stranded RNA binding GO:0003727 8.96 DHX58 DDX58
3 double-stranded RNA binding GO:0003725 8.8 TFRC DHX58 DDX58

Sources for Bolivian Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....