MCID: BNB001
MIFTS: 26

Bone Benign Neoplasm

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Benign Neoplasm

MalaCards integrated aliases for Bone Benign Neoplasm:

Name: Bone Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060094

Summaries for Bone Benign Neoplasm

Disease Ontology : 12 A connective tissue benign neoplasm that is located in bone.

MalaCards based summary : Bone Benign Neoplasm is related to ossifying fibroma and bone ameloblastoma. An important gene associated with Bone Benign Neoplasm is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include bone, brain and breast, and related phenotypes are craniofacial and limbs/digits/tail

Related Diseases for Bone Benign Neoplasm

Diseases related to Bone Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 ossifying fibroma 31.7 USP6 SERPINA3 PTH GNAS CDC73
2 bone ameloblastoma 11.1
3 phalanx chondroma 11.1
4 osteoblastoma 11.1
5 adult brain stem glioma 10.4 H3-3B H3-3A
6 salpingo-oophoritis 10.4 CDC73 CD68
7 congenital epulis 10.4 SERPINA3 CD68
8 epulis 10.4 SERPINA3 CD68
9 verruciform xanthoma of skin 10.4 SERPINA3 CD68
10 breast leiomyosarcoma 10.4 TNFSF11 CD68
11 malignant inflammatory fibrous histiocytoma 10.4 SERPINA3 CD68
12 kummell's disease 10.4 TNFSF11 CALCA
13 reticulohistiocytic granuloma 10.4 SERPINA3 CD68
14 pancreas sarcoma 10.4 SERPINA3 CD68
15 xanthogranulomatous pyelonephritis 10.4 SERPINA3 CD68
16 spinal cord astrocytoma 10.4 H3-3B H3-3A
17 adult oligodendroglioma 10.4 H3-3B H3-3A
18 childhood oligodendroglioma 10.4 H3-3B H3-3A
19 sarcomatoid squamous cell skin carcinoma 10.4 SERPINA3 CD68
20 paget disease of bone 5, juvenile-onset 10.4 TNFSF11 CALCA
21 clear cell chondrosarcoma 10.4 SERPINA3 H3-3B H3-3A
22 malignant granular cell myoblastoma 10.4 SERPINA3 CD68
23 clear cell adenoma 10.4 PTH CDC73
24 chondroblastic osteosarcoma 10.4 SERPINA3 H3-3B H3-3A
25 liver sarcoma 10.4 SERPINA3 CD68
26 pleomorphic xanthoastrocytoma 10.4 SERPINA3 H3-3B H3-3A
27 pleomorphic lipoma 10.4 SERPINA3 CD68
28 substernal goiter 10.4 PTH CALCA
29 diffuse astrocytoma 10.3 SERPINA3 H3-3B H3-3A
30 central nervous system benign neoplasm 10.3 SERPINA3 H3-3B H3-3A
31 telangiectatic osteogenic sarcoma 10.3 USP6 H3-3B H3-3A
32 xanthogranulomatous cholecystitis 10.3 SERPINA3 CD68
33 malignant giant cell tumor 10.3 H3-3B H3-3A CD68
34 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.3 CSF1R CSF1
35 proliferative fasciitis 10.3 USP6 SERPINA3 CD68
36 histiocytic and dendritic cell cancer 10.3 SERPINA3 CD68
37 aneurysmal bone cysts 10.3 USP6 TNFSF11 CALCA
38 pseudosarcomatous fibromatosis 10.3 USP6 SERPINA3 CD68
39 synovitis 10.3 TNFSF11 CD68 ACP5
40 intravascular fasciitis 10.3 USP6 CD68
41 femoral cancer 10.3 TNFSF11 ACP5
42 villonodular synovitis 10.3 CSF1 CD68 ACP5
43 malignant ovarian brenner tumor 10.3 TNFSF11 PTH CALCA
44 childhood brain stem glioma 10.3 H3-3B H3-3A
45 gorham's disease 10.3 TNFSF11 PTH CALCA
46 hypocalciuric hypercalcemia, familial, type i 10.3 PTH CDC73
47 hypocalciuric hypercalcemia, familial, type ii 10.3 PTH CDC73
48 giant cell glioblastoma 10.3 SERPINA3 H3-3B H3-3A
49 hypersensitivity reaction type iv disease 10.3 SERPINA3 PTH CD68
50 bone giant cell sarcoma 10.3 TNFSF11 H3-3B H3-3A CSF1

Graphical network of the top 20 diseases related to Bone Benign Neoplasm:



Diseases related to Bone Benign Neoplasm

Symptoms & Phenotypes for Bone Benign Neoplasm

MGI Mouse Phenotypes related to Bone Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.85 AMBN CDC73 CSF1 CSF1R CTSK GNAS
2 limbs/digits/tail MP:0005371 9.5 CSF1 CSF1R CTSK GNAS PTH SH3BP2
3 skeleton MP:0005390 9.36 AMBN CD68 CDC73 COL6A3 CSF1 CSF1R

Drugs & Therapeutics for Bone Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Bone Benign Neoplasm

Genetic Tests for Bone Benign Neoplasm

Anatomical Context for Bone Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Benign Neoplasm:

19
Bone

MalaCards organs/tissues related to Bone Benign Neoplasm:

40
Bone, Brain, Breast, Skin, Bone Marrow, Spinal Cord, Colon

Publications for Bone Benign Neoplasm

Variations for Bone Benign Neoplasm

Expression for Bone Benign Neoplasm

Search GEO for disease gene expression data for Bone Benign Neoplasm.

Pathways for Bone Benign Neoplasm

GO Terms for Bone Benign Neoplasm

Cellular components related to Bone Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 TNFSF11 SERPINA3 PTH ODAM CTSK CSF1
2 extracellular region GO:0005576 9.4 TNFSF11 SERPINA3 PTH ODAM H3-3B H3-3A
3 Barr body GO:0001740 9.16 H3-3B H3-3A
4 CSF1-CSF1R complex GO:1990682 8.96 CSF1R CSF1

Biological processes related to Bone Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.92 SERPINA3 ODAM CSF1R CSF1 CALCA
2 multicellular organism growth GO:0035264 9.72 H3-3B H3-3A GNAS
3 embryo implantation GO:0007566 9.61 H3-3B H3-3A CALCA
4 muscle cell differentiation GO:0042692 9.58 H3-3B H3-3A
5 positive regulation of macrophage chemotaxis GO:0010759 9.57 CSF1R CSF1
6 positive regulation of macrophage differentiation GO:0045651 9.56 CSF1 CALCA
7 microglial cell proliferation GO:0061518 9.54 CSF1R CSF1
8 osteoclast differentiation GO:0030316 9.54 TNFSF11 CSF1R CSF1
9 response to parathyroid hormone GO:0071107 9.51 PTH GNAS
10 macrophage colony-stimulating factor signaling pathway GO:0038145 9.49 CSF1R CSF1
11 pericentric heterochromatin assembly GO:0031508 9.48 H3-3B H3-3A
12 osteoclast proliferation GO:0002158 9.46 TNFSF11 CSF1
13 cellular protein metabolic process GO:0044267 9.43 ODAM H3-3B H3-3A CSF1 CALCA AMBN
14 regulation of centromere complex assembly GO:0090230 9.4 H3-3B H3-3A
15 positive regulation of osteoclast differentiation GO:0045672 9.33 TNFSF11 GNAS CSF1
16 negative regulation of chromosome condensation GO:1902340 9.32 H3-3B H3-3A
17 telomeric heterochromatin assembly GO:0031509 9.26 H3-3B H3-3A
18 bone resorption GO:0045453 8.92 TNFSF11 PTH CTSK ACP5

Sources for Bone Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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